Cortex Quotes

For the first time in longer than I can remember, I feel peaceful. Not happy. Not sad. Not anxious. Not horny. Just all the higher parts of my brain closing up shop. The cerebral cortex. The cerebellum. That's where my problem is. I'm now simplifying myself. Somewhere balanced in the perfect middle between happiness and sadness. Because sponges never have a bad day.

I did not know that my entire personality, my entire being, could be discarded as the byproduct of my anatomy. What if I really am just someone with a large prefrontal cortex...and nothing more?

On an incredibly simplistic level, you can think of depression as occurring when your cortex thinks an abstract thought and manages to convince the rest of the brain that this is as real as a physical stressor.

The good part about having a mental disorder is having a valid reason for all the stupid things we do because of a damaged prefrontal cortex. However, the best part is seeing someone completely sane do the exact same things, without a valid excuse. This is the great equalizer of God and his little gift for all us crazy people to enjoy.

Civilization is a product of the cerebral cortex.

The brain is heavily influenced by genes. But from birth through young adulthood, the part of the human brain that most defines us (frontal cortex) is less a product of the genes with which you started life than of what life has thrown at you. Because it is the last to mature, by definition the frontal cortex is the brain region least constrained by genes and most sculpted by experience. This must be so, to be the supremely complex social species that we are. Ironically, it seems that the genetic program of human brain development has evolved to, as much as possible, free the frontal cortex from genes.

It's also awkward to be so short you can see all the way up into someone's cerebral cortex, but welcome to my life.

Meditation is blossoming of the prefrontal cortex to overcome the momentum of the nature. It is coming out of the loops of memories, patterns,fears, dreams and anger.

Just sitting quietly, doing nothing at all, your brain churns through more information in thirty seconds than the Hubble Space Telescope has processed in thirty years. A morsel of cortex one cubic millimeter in size—about the size of a grain of sand—could hold two thousand terabytes of information, enough to store all the movies ever made, trailers included, or about 1.2 billion copies of this book.

Mindfulness increases activation of the medial prefrontal cortex and decreases activation of structures like the amygdala that trigger our emotional responses. This increases our control over the emotional brain.

The lie that abortion is murder is right-wing propaganda designed to demonize Democrats. Abortion is legal all over the world because a fetus without a cerebral cortex cannot think or feel before the 27th week. According to the CDC almost all abortions happen before the 13th week.

You know, Vik, you’re amazingly human at times. (Alix) I know. But I wonder if the feelings I have are real or just electrical stimulations in my cortex that simulate human emotion. I wish I knew if they were real or imagined. (Vik) And that makes you completely human, sweetie. We all have those doubts. (Alix)

The contrast with the scans of the eighteen chronic PTSD patients with severe early-life trauma was startling. There was almost no activation of any of the self-sensing areas of the brain: The MPFC, the anterior cingulate, the parietal cortex, and the insula did not light up at all; the only area that showed a slight activation was the posterior cingulate, which is responsible for basic orientation in space. There could be only one explanation for such results: In response to the trauma itself, and in coping with the dread that persisted long afterward, these patients had learned to shut down the brain areas that transmit the visceral feelings and emotions that accompany and define terror. Yet in everyday life, those same brain areas are responsible for registering the entire range of emotions and sensations that form the foundation of our self-awareness, our sense of who we are. What we witnessed here was a tragic adaptation: In an effort to shut off terrifying sensations, they also deadened their capacity to feel fully alive.

One can speculate that the tardiness and wobbliness of humanity's progress on many of the "eternal problems" of philosophy are due to the unsuitability of the human cortex for philosophical work. On this view, our most celebrated philosophers are like dogs walking on their hind legs - just barely attaining the treshold level of performance required for engaging in the activity at all.

The part of the brain most affected by early stress is the prefrontal cortex, which is critical in self-regulatory activities of all kinds, both emotional and cognitive. As a result, children who grow up in stressful environments generally find it harder to concentrate, harder to sit still, harder to rebound from disappointments, and harder to follow directions. And that has a direct effect on their performance in school.

The warmth and satisfaction of positive contact with the adult is often just as good as a psychostimulant in supplying the child’s prefrontal cortex with dopamine.

The brain does much more than recollect. It compares, synthesizes, analyzes, generates abstractions. We must figure out much more than our genes can know. That is why the brain library is some ten thousand times larger than the gene library. Our passion for learning, evident in the behaviour of every toddler, is the tool for our survival. Emotions and ritualized behaviour patterns are built deeply into us. They are part of our humanity. But they are not characteristically human. Many other animals have feelings. What distinguishes our species is thought. The cerebral cortex is a liberation. We need no longer be trapped in the genetically inherited behaviour patterns of lizards and baboons. We are, each of us, largerly responsible for what gets put into our brains, for what, as adults, we wind up caring for and knowing about. No longer at the mercy of the reptile brain, we can change ourselves.

How do we regulate our emotions? The answer is surprisingly simple: by thinking about them. The prefrontal cortex allows each of us to contemplate his or her own mind, a talent psychologists call metacognition. We know when we are angry; every emotional state comes with self-awareness attached, so that an individual can try to figure out why he's feeling what he's feeling. If the particular feeling makes no sense—if the amygdala is simply responding to a loss frame, for example—then it can be discounted. The prefrontal cortex can deliberately choose to ignore the emotional brain.

Left-nostril breathing shifts blood flow to the opposite side of the prefrontal cortex, the right area that plays a role in creative thought, emotions, formation of mental abstractions, and negative emotions.

Multitasking has been found to increase the production of the stress hormone cortisol as well as the fight-or-flight hormone adrenaline, which can overstimulate your brain and cause mental fog or scrambled thinking. Multitasking creates a dopamine-addiction feedback loop, effectively rewarding the brain for losing focus and for constantly searching for external stimulation. To make matters worse, the prefrontal cortex has a novelty bias, meaning that its attention can be easily hijacked by something new—the proverbial shiny objects

Judging by your face, the what-the-fuck nodes in your cerebral cortex must be a real light show.

Think of cocaine. In its natural form, as coca leaves, it's appealing, but not to an extent that it usually becomes a problem. But refine it, purify it, and you get a compound that hits your pleasure receptors with an unnatural intensity. That's when it becomes addictive. Beauty has undergone a similar process, thanks to advertisers. Evolution gave us a circuit that responds to good looks - call it the pleasure receptor for our visual cortex - and in our natural environment, it was useful to have. But take a person with one-in-a-million skin and bone structure, add professional makeup and retouching, and you're no longer looking at beauty in its natural form. You've got pharmaceutical-grade beauty, the cocaine of good looks. Biologists call this "supernormal stimulus" [...] Our beauty receptors receive more stimulation than they were evolved to handle; we're seeing more beauty in one day than our ancestors did in a lifetime. And the result is that beauty is slowly ruining our lives. How? The way any drug becomes a problem: by interfering with our relationships with other people. We become dissatisfied with the way ordinary people look because they can't compare to supermodels.

We are part of nature, a product of a long evolutionary journey. To some degree, we carry the ancient oceans in our blood. … Our brains and nervous systems did not suddenly spring into existence without long antecedents in natural history. That which we most prize as integral to our humanity - our extraordinary capacity to think on complex conceptual levels - can be traced back to the nerve network of primitive invertebrates, the ganglia of a mollusk, the spinal cord of a fish, the brain of an amphibian, and the cerebral cortex of a primate.

Who knows what I want to do? Who knows what anyone wants to do? How can you be sure about something like that? Isn't it all a question of brain chemistry, signals going back and forth, electrical energy in the cortex? How do you know whether something is really what you want to do or just some kind of nerve impulse in the brain? Some minor little activity takes place somewhere in this unimportant place in one of the brain hemispheres and suddenly I want to go to Montana or I don't want to go to Montana. How do I know I really want to go and it isn't just some neurons firing or something? Maybe it's just an accidental flash in the medulla and suddenly there I am in Montana and I find out I really didn't want to go there in the first place. I can't control what happens in my brain, so how can I be sure what I want to do ten seconds from now, much less Montana next summer? It's all this activity in the brain and you don't know what's you as a person and what's some neuron that just happens to fire or just happens to misfire.

She sat in her chair, eyes closed. She liked to be the last one to leave. She despised crowds, and their opinions as they left a performance, or worse, discussed the wait for the bathroom or where do you want to eat. It spoiled her mood. She was still in that other world, she would stay there as long as she possibly could, the parallel channels twining and tunneling through her cortex like coral.

Beatrice closed her eyes and dreamed whatever flowers dream. Beatrice: That's very poetic, but they don't dream anything. Flowers have no cerebral cortex.

Recent brain scans have shed light on how the brain simulates the future. These simulation are done mainly in the dorsolateral prefrontal cortex, the CEO of the brain, using memories of the past. On one hand, simulations of the future may produce outcomes that are desirable and pleasurable, in which case the pleasure centers of the brain light up (in the nucleus accumbens and the hypothalamus). On the other hand, these outcomes may also have a downside to them, so the orbitofrontal cortex kicks in to warn us of possible dancers. There is a struggle, then, between different parts of the brain concerning the future, which may have desirable and undesirable outcomes. Ultimately it is the dorsolateral prefrontal cortex that mediates between these and makes the final decisions. (Some neurologists have pointed out that this struggle resembles, in a crude way, the dynamics between Freud's ego, id, and superego.)

Indeed, brain scans done by scientists at Washington University in St. Louis indicate that areas used to recall memories are the same as those involved in simulating the future. In particular, the link between the dorsolateral prefrontal cortex and the hippocampus lights up when a person is engaged in planning for the future and remembering the past.

Then you and that mutt hijacked my thoughts and started dancing Gangnam Style on my cerebral cortex.

...he'd know about the role of mirror neurons in the brain, special cells in the premotor cortex that fire right before a person reaches for a rock, steps forward, turns away, begins to smile.Amazingly, the same neurons fire whether we do something or watch someone else do the same thing, and both summon similar feelings. Learning form our own mishaps isn't as safe as learning from someone else's, which helps us decipher the world of intentions, making our social whirl possible. The brain evolved clever ways to spy or eavesdrop on risk, to fathom another's joy or pain quickly, as detailed sensations, without resorting to words. We feel what we see, we experience others as self.

...but there is every reason to think that the bulging cortex which would later measure stars and ice ages was still a dim, impoverished region in a skull box whose capacity was no greater than that of great apes.

probably the most important fact about genetics and culture is the delayed maturation of the frontal cortex—the genetic programming for the young frontal cortex to be freer from genes than other brain regions, to be sculpted instead by environment, to sop up cultural norms. To hark back to a theme from the first pages of this book, it doesn’t take a particularly fancy brain to learn how to motorically, say, throw a punch. But it takes a fancy, environmentally malleable frontal cortex to learn culture-specific rules about when it’s okay to throw punches.

Second, nothing about adolescence can be understood outside the context of delayed frontocortical maturation. If by adolescence limbic, autonomic, and endocrine systems are going full blast while the frontal cortex is still working out the assembly instructions, we’ve just explained why adolescents are so frustrating, great, asinine, impulsive, inspiring, destructive, self-destructive, selfless, selfish, impossible, and world changing. Think about this—adolescence and early adulthood are the times when someone is most likely to kill, be killed, leave home forever, invent an art form, help overthrow a dictator, ethnically cleanse a village, devote themselves to the needy, become addicted, marry outside their group, transform physics, have hideous fashion taste, break their neck recreationally, commit their life to God, mug an old lady, or be convinced that all of history has converged to make this moment the most consequential, the most fraught with peril and promise, the most demanding that they get involved and make a difference. In other words, it’s the time of life of maximal risk taking, novelty seeking, and affiliation with peers. All because of that immature frontal cortex.

The parts of your brain that are now activated include the same neurons in your visual cortex that would be activated if you were actually looking

At this moment, in this place, the shifting action potential in my neurons cascade into certain arrangements, patterns, thoughts; they flow down my spine, branch into my arms, my fingers, until muscles twitch and thought is translated into motion; mechanical levers are pressed; electrons are rearranged; marks are made on paper. At another time, in another place, light strikes the marks, reflects into a pair of high-precision optical instruments sculpted by nature after billions of years of random mutations; upside-down images are formed against two screens made up of millions of light-sensitive cells, which translate light into electrical pulses that go up the optic nerves, cross the chiasm, down the optic tracts, and into the visual cortex, where the pulses are reassembled into letters, punctuation marks, words, sentences, vehicles, tenors, thoughts. The entire system seems fragile, preposterous, science fictional.

If you (or any other mammal) bite into rancid food, the insular cortex lights up, causing you to spit it out, gag, feel nauseated, make a revolted facial expression—the insular cortex processes gustatory disgust. Ditto for disgusting smells.

Language and hearing are seated in the cerebral cortex, the folded gray matter that covers the first couple of millimeters of the outer brain like wrapping paper. When one experiences silence, absent even reading, the cerebral cortex typically rests. Meanwhile, deeper and more ancient brain structures seem to be activated--the subcortical zones. People who live busy, noisy lives are rarely granted access to these areas. Silence, it appears, is not the opposite of sound. It is another world altogether, literally offering a deeper level of thought, a journey to the bedrock of the self.

Meditate. Neuroscientists have found that monks who spend years meditating actually grow their left prefrontal cortex, the part of the brain most responsible for feeling happy. But don’t worry, you don’t have to spend years in sequestered, celibate silence to experience a boost. Take just five minutes each day to watch your breath go in and out.

One reason we can change our brains simply by imagining is that, from a neuroscientific point of view, imagining an act and doing it are not as different as they sound. When people close their eyes and visualize a simple object, such as the letter a, the primary visual cortex lights up, just as it would if the subjects were actually looking at the letter a. Brain scans show that in action and imagination many of the same parts of the brain are activated. That is why visualizing can improve performance.

We live in the Age of the Higher Brain, the cerebral cortex that has grown enormously over the last few millennia, overshadowing the ancient, instinctive lower brain. The cortex is often called the new brain, yet the old brain held sway in humans for millions of years, as it does today in most living things. The old brain can’t conjure up ideas or read. But it does possess the power to feel and, above all, to be. It was the old brain that caused our forebears to sense the closeness of a mysterious presence everywhere in Nature.

People and their pets connect via shared brain structures that predate the development of the human frontal cortex with its apparatus of language and rationality. Animals and humans interact from their respective limbic systems, the brain’s emotional parts. Unlike people, animals are acutely sensitive to messages from the limbic brain—both their own and that of their owners.

Experiements that have been devised to inflict even mild social pain (like exclusion form a group task or betrayal by a partner in a gambling game) have demonstrated significant activation of the sinula and the anterior cingulate cortex. Emotional pain isn't just a metaphor: In terms of brain activation, it partially overlaps with physical pain.

stimulation of the medial frontal cortex gives one the feeling of the urge to move

The adolescent brain makes important new pathways and connections, but the cognitive functions of the prefrontal cortex, the seat of judgment, don’t mature until around age twenty-five. (The emotional control functions follow at around thirty-two!)

All day you have been on my mind, a steam iron pressing the convolutions from my cortex, ironing me flat. Worrying cooks my cells feverish. I am irritable with love boiling into anxiety, till I grow furious with you, lying under the surgeon’s knife.

right nostril is a gas pedal. When you’re inhaling primarily through this channel, circulation speeds up, your body gets hotter, and cortisol levels, blood pressure, and heart rate all increase. This happens because breathing through the right side of the nose activates the sympathetic nervous system, the “fight or flight” mechanism that puts the body in a more elevated state of alertness and readiness. Breathing through the right nostril will also feed more blood to the opposite hemisphere of the brain, specifically to the prefrontal cortex, which has been associated with logical decisions, language, and computing. Inhaling through the left nostril has the opposite effect: it works as a kind of brake system to the right nostril’s accelerator. The left nostril is more deeply connected to the parasympathetic nervous system, the rest-and-relax side that lowers blood pressure, cools the body, and reduces anxiety. Left-nostril breathing shifts blood flow to the opposite side of the prefrontal cortex, to the area that influences creative thought and plays a role in the formation of mental abstractions and the production of negative emotions.

Let me tell you, though: being the smartest boy in the world wasn’t easy. I didn’t ask for this. I didn’t want this. On the contrary, it was a huge burden. First, there was the task of keeping my brain perfectly protected. My cerebral cortex was a national treasure, a masterpiece of the Sistine Chapel of brains. This was not something that could be treated frivolously. If I could have locked it in a safe, I would have. Instead, I became obsessed with brain damage.

You can change dopamine and the dorsal striatum with exercise. You can boost serotonin with a massage. You can make decisions and set goals to activate the ventromedial prefrontal cortex. You can reduce amygdala activity with a hug and increase anterior cingulate activity with gratitude. You can enhance prefrontal norepinephrine with sleep.

So many cells in my body have died and regenerated since the days of the Dream House. My blood and taste buds and skin have long since re-created themselves. My fat still remembers, but just barely — within a few years, it will have turned itself over completely. My bones too. But my nervous system remembers. The lenses of my eyes. My cerebral cortex with its memory and language and consciousness. They will last forever, or at least as long as I do. They can still climb onto the witness stand.

There's a class of things to be afraid of: it's "those things that you should be afraid of". Those are the things that go bump in the night, right? You're always exposed to them when you go to horror movies, especially if they're not the gore type of horror movie. They're always hinting at something that's going on outside of your perceptual sphere, and they frighten you because you don't know what's out there. For that the Blair Witch Project was a really good example, because nothing ever happens in that movie but it's frightenting and not gory. It plays on the fact tht you do have a category of Those Things Of Which You Should Be Afraid. So it's a category, frightening things. And only things capable of abstraction can come up with something like the caregory of frightenting things. And so Kali is like an embodied representation of the category of frightening things. And then you might ask yourself, well once you come up with the concept of the category of frightening things, maybe you can come up with the concept of what to do in the face of frightening things. Which is not the same as "what do you do when you encounter a lion", or "what do you do when you encounter someone angry". It's a meta question, right? But then you could say, at a philosophical level: "You will encounter elements of the category of all those things which can frighten and undermine you during your life. Is there something that you can do *as a category* that would help you deal with that." And the answer is yeah, there is in fact. And that's what a lot of religious stories and symbolic stories are trying to propose to you, is the solution to that. One is, approach it voluntarily. Carefully, but voluntarily. Don't freeze and run away. Explore, instead. You expose yourself to risk but you gain knowledge. And you wouldn't have a cortex which, you know, is ridiculously disproportionate, if as a species we hadn't decided that exploration trumps escape or freezing. We explore. That can make you the master of a situation, so you can be the master of something like fire without being terrified of it. One of the things that the Hindus do in relationship to Kali, is offer sacrifices. So you can say, well why would you offer sacrifices to something you're afraid of. And it's because that is what you do, that's always what you do. You offer up sacrifices to the unknown in the hope that good things will happen to you. One example is that you're worried about your future. Maybe you're worried about your job, or who you're going to marry, or your family, there's a whole category of things to be worried about, so you're worried about your future. SO what're you doing in university? And the answer is you're sacrificing your free time in the present, to the cosmos so to speak, in the hope that if you offer up that sacrifice properly, the future will smile upon you. And that's one of the fundamental discoveries of the human race. And it's a big deal, that discovery: by changing what you cling to in the present, you can alter the future.

You recently read me a quote by Faulkner: "The past isn't dead, it's not even past." So much of our adult lives is influenced by what happened to us as children. It is all still there, the memories, the feelings, and fears, stored just beneath the surface in the hidden crannies of our cortex.

That big glorious mountain. For one transitory moment, I think I may have actually seen it”. For one flash, the Mommy had seen the mountain without thinking of logging and ski resorts and avalanches, managed wildlife, plate tectonic geology, microclimates, rain shadow, or yin-yang locations. She’d seen the mountain without the framework of language. Without the cage of associations. She’d seen it without looking through the lens of everything she knew was true about mountains. What she’d seen in that flash wasn’t even a “mountain”. It wasn’t a natural resource. It had no name. “That’s the big goal”, she said. “To find a cure for knowledge”. For education. For living in our heads. Ever since the story of Adam and Eve in the bible, humanity had been a little too smart for its own good, the Mommy said. Ever since eating that apple. Her goal was to find, if not a cure, then at least a treatment that would give people back their innocence. “The cerebral cortex, the cerebellum”, she said, “that’s where your problem is”. If she could just get down to using only her brain stem, she’d be cured. This would be somewhere beyond happiness and sadness. You don’t see fish agonized by wild mood swings. Sponges never have a bad day.

There is no other species on Earth that does science. It is, so far, entirely a human invention, evolved by natural selection in the cerebral cortex for one simple reason: it works. It is not perfect. It can be misused. It is only a tool. But it is by far the best tool we have, self-correcting, ongoing, applicable to everything.

That baby sees the world with completeness that you and I will never know again. His doors of perception have not yet been closed. He still experiences the moment he lives in. The inevitable bullshit hasn't constipated his cerebral cortex yet. He still sees the world as it really is, while we sit here, left with only a dim historical version of it manufactured for us by words and official bullshit, and so forth and so on..

The cerebral cortex is a liberation. We need no longer be trapped in the genetically inherited behavior patterns of lizards and baboons. We are, each of us, largely responsible for what gets put into our brains, for what, as adults, we wind up caring for and knowing about. No longer at the mercy of the reptile brain, we can change ourselves.

Professional musicians, in general, possess what most of us would regard as remarkable powers of musical imagery. Many composers, indeed, do not compose initially or entirely at an instrument but in their minds. There is no more extraordinary example of this than Beethoven, who continued to compose (and whose compositions rose to greater and greater heights) years after he had become totally deaf. It is possible that his musical imagery was even intensified by deafness, for with the removal of normal auditory input, the auditory cortex may become hypersensitive, with heightened powers of musical imagery (and sometimes even auditory hallucinations).

When I was cooking I enjoyed a sense of being ‘out’ of myself. The action of dicing vegetables and warming oil made my hands tingle and my thoughts switch to a different hemisphere, right brain rather than left, or left rather than right. In my mind there were many rooms and, just as I still got lost in the labyrinth of corridors at college, I often found myself lost, with a sense of déjà vu, in some obscure part of my cerebral cortex, the part of the brain that plays a key role in perceptual awareness, attention and memory. Everything I had lived through or imagined or dreamed appeared to have been backed up on a video clip and then scattered among those alien rooms. I could stumble into any number of scenes, from the horrifically sexual, horror-movie sequences that were crude and painful, to visualizing Grandpa polishing his shoes.

For many men, just seeing a woman in a sexually objectifying pose, such as in a bikini, deactivates the part of the brain's prefrontal cortex, the part of the brain where thinking about people and their intentions, feelings and actions happens. Instead, the region of the brain that lights up... is the one that reacts to looking at inanimate objects, such as a pen or a ball.

Destiny is no more than the fulfillment of purposive potentialities within us. The human cerebral cortex is a single sheet composed of more neurons than there are stars in the known universe folded like a paper crane to fit in a quart-sized cubbyhole; there is enough potential energy in a single person that if released would equal thirty hydrogen bombs. Destiny is nothing to sneeze at!

the brain is hardwired to allow the amygdala to seize control in times of danger. And because of this wiring, it’s difficult to directly use reason-based thought processes arising in the higher levels of the cortex to control amygdala-based anxiety. You may have already recognized that your anxiety often doesn’t make sense to your cortex, and that your cortex can’t just reason it away.

Despite his title, the Secretary of the Interior was a shallow man. He was given to surfaces, not depths; to cortex, not medulla; to the puff, not the cream. He didn't understand the interior of anything: not the interior of a tenor sax solo, a painting or a poem; not the interior of an atom, a planet, a spider or his wife's body; not the interior, least of all, of his own heart and head.

Pavlov was fascinated with the “ideas of the opposite”. Call it a cluster of cells, somewhere on the cortex of the brain. Helping to disintiguish pleasure from pain, light from dark, dominance from submission….but when somehow – starve them, traumatize, castrate them send them over into one of the transmarginal phases, past borders of their waking selves, past equivalent and paradoxical phases – you weaken this idea of the opposite, and here all at once is the paranoid patient, who would be master, yet now feels himself a slave…..who would be loved, but suffers his world’s indifference, and “I think”, Pavlov writing to Janet, “it is precisely the ultraparadoxical phase which is the base of the weakening of the idea of the opposite in our patients. Our madmen, , our paranoid, maniac, schizoid, morally imbecilic. Spectro shakes his head. “You are putting response before stimulus. Not at all. Think about it. He is out there, he can feel them coming, days in advance, but it is a reflex. A reflex to something that is in the air right now, something were too coarsely put together to sense, but Slothrop can.

There is overwhelming evidence that meditation can increase focus and decrease anxiety, depression, and cortisol flooding. There is evidence that it decreases activation in the amygdala, one epicenter of fear in the brain, and increases activity in the prefrontal cortex. People who meditate are able to unstick themselves from cyclical, dangerous thinking and see things from a calmer, more positive perspective. The sympathetic nervous system, or the fight or flight system, is activated by stress. This is the system that gets us ready to run. The counter to this is the parasympathetic nervous system, the resting and digesting system. It lowers heart rate and blood pressure, slows breathing, and directly counters the stress response. Meditation activates the parasympathetic nervous system. It’s literally the antidote to stress. Plus, it’s what all the evolved, cool girls who look good without makeup are doing, according to social media.

Our visual cortexes are wired to quickly recognize faces and then quickly subtract massive amounts of detail from them, zeroing in on their essential message: Is this person happy? Angry? Fearful? Individual faces may vary greatly, but a smirk on one is a lot like a smirk on another. Smirks are conceptual, not pictorial. Our brains are like cartoonists - and cartoonists are like our brains, simplifying and exaggerating, subordinating facial detail to abstract comic concepts.

One stretch of the gene is repeated a variable number of times, and the version with seven repeats (the “7R” form) produces a receptor protein that is sparse in the cortex and relatively unresponsive to dopamine. This is the variant associated with a host of related traits—sensation and novelty seeking, extroversion, alcoholism, promiscuity, less sensitive parenting, financial risk taking, impulsivity, and, probably most consistently, ADHD (attention-deficit/hyperactivity disorder).

Uncouth, clannish, lumbering about the confines of Space and Time with a puzzled expression on his face and a handful of things scavenged on the way from gutters, interglacial littorals, sacked settlements and broken relationships, the Earth-human has no use for thinking except in the service of acquisition. He stands at every gate with one hand held out and the other behind his back, inventing reasons why he should be let in. From the first bunch of bananas, his every sluggish fit or dull fleabite of mental activity has prompted more, more; and his time has been spent for thousands of years in the construction and sophistication of systems of ideas that will enable him to excuse, rationalize, and moralize the grasping hand. His dreams, those priceless comic visions he has of himself as a being with concerns beyond the material, are no more than furtive cannibals stumbling round in an uncomfortable murk of emotion, trying to eat each other. Politics, religion, ideology — desperate, edgy attempts to shift the onus of responsibility for his own actions: abdications. His hands have the largest neural representation in the somesthetic cortex, his head the smallest; but he's always trying to hide the one behind the other.

Attention words. A single word wasn't enough. Not even for a particular segment. The brain had defenses, filters evolved over millions of years to protect against manipulation. The first was perception, the process of funneling an ocean of sensory input down to a few key data packages worthy of study by the cerebral cortex. When data got by the perception filter, it received attention. And she saw now that it must be like that all the way down: There must be words to attack each filter. Attention words and then maybe desire words and logic words and urgency words and command words. This was what they were teaching her. How to craft a string of words that would disable the filters one by one, unlocking each mental tumbler until the mind's last door swung open.

Stress and glucocorticoids have inverted-U effects here as well. Moderate, transient stress (or exposure to the equivalent glucocorticoid levels) increases spine number in the hippocampus; sustained stress or glucocor-ticoid exposure does the opposite.7 Moreover, major depression or anxiety—two disorders associated with elevated glucocorticoid levels—can reduce hippocampal dendrite and spine number. This arises from decreased levels of that key growth factor mentioned earlier this chapter, BDNF. Sustained stress and glucocorticoids also cause dendritic retraction and synapse loss, lower levels of NCAM (a “neural cell adhesion molecule” that stabilizes synapses), and less glutamate release in the frontal cortex.

Classifying depression as an illness serves the psychiatric community and pharmaceutical corporations well; it also soothes the frightened, guilty, indifferent, busy, sadistic, and unschooled. To understand depression as a call for life-changes is not profitable. Stagnation is not a medical term. The 17.5 million Americans diagnosed as suffering a major depression in 1997 were mostly damned. (Psychobiological examinations confuse cause and symptom.) Deficient serotonergic functioning, ventral prefrontal cerebral cortex, dis-inhibition of impulsive-aggressive behavior, blah blah blah: the medical lexicon boils emotion from human being. Go take a drug, the doctor says. Pain is a biochemical phenomenon. Erase all memory.

Much of what we do arises from automatic programming that bypasses conscious awareness and may even run contrary to our intentions, as Dr. Schwartz points out: The passive side of mental life, which is generated solely and completely by brain mechanisms, dominates the tone and tenor of our day-to-day, even our second-to-second experience. During the quotidian business of daily life, the brain does indeed operate very much as a machine does. Decisions that we may believe to be freely made can arise from unconscious emotional drives or subliminal beliefs. They can be dictated by events of which we have no recollection. The stronger a person’s automatic brain mechanisms and the weaker the parts of the brain that can impose conscious control, the less true freedom that person will be able to exercise in her life. In OCD, and in many other conditions, no matter how intelligent and well-meaning the individual, the malfunctioning brain circuitry may override rational judgment and intention. Almost any human being when overwhelmed by stress or powerful emotions, will act or react not from intention but from mechanisms that are set off deep in the brain, rather than being generated in the conscious and volitional segments of the cortex. When acting from a driven or triggered state, we are not free.

Think of cocaine. In its natural form, as coca leaves, it's appealing, but not to an extent that it usually becomes a problem. But refine it, purify it, and you get a compound that hits your pleasure receptors with an unnatural intensity. That's when it becomes addictive. Beauty has undergone a similar process, thanks to advertisers.Evolution gave us a circuit that responds to good looks--call it the pleasure receptor for our visual cortex--and in our natural environment, it was useful to have. But take a person with one-in-a-million skin and bone structure, add professional makeup and retouching, and you're no longer looking at beauty in its natural form. You've got pharmaceutical grade beauty, the cocaine of good looks.

There will come a time when a person you most likely pushed out through your vagina and nursed from your nipples, whose bottom you wiped, and whose snot and spit you cleaned up over several sleep-starved years will apprehend you with a mixture of boredom and irritation and say, ‘Get a life, Mum.’ This would be a good time to remember that a) violence never solved anything; b) teenagers don’t have a full brain yet – the prefrontal cortex that controls the ability to make important distinctions, like who controls the pocket money, only kicks in around the age of twenty-four; and c) you are, in fact, the adult.

There’s a lot of scientific evidence demonstrating that focused attention leads to the reshaping of the brain. In animals rewarded for noticing sound (to hunt or to avoid being hunted, for example), we find much larger auditory centers in the brain. In animals rewarded for sharp eyesight, the visual areas are larger. Brain scans of violinists provide more evidence, showing dramatic growth and expansion in regions of the cortex that represent the left hand, which has to finger the strings precisely, often at very high speed. Other studies have shown that the hippocampus, which is vital for spatial memory, is enlarged in taxi drivers. The point is that the physical architecture of the brain changes according to where we direct our attention and what we practice doing.

Here’s how to get started: 1. Sit still and stay put . Sit in a chair with your feet flat on the ground, or sit cross-legged on a cushion. Sit up straight and rest your hands in your lap. It’s important not to fidget when you meditate—that’s the physical foundation of self-control. If you notice the instinct to scratch an itch, adjust your arms, or cross and uncross your legs, see if you can feel the urge but not follow it. This simple act of staying still is part of what makes meditation willpower training effective. You’re learning not to automatically follow every single impulse that your brain and body produce. 2. Turn your attention to the breath. Close your eyes or, if you are worried about falling asleep, focus your gaze at a single spot (like a blank wall, not the Home Shopping Network). Begin to notice your breathing. Silently say in your mind “inhale” as you breathe in and “exhale” as you breathe out. When you notice your mind wandering (and it will), just bring it back to the breath. This practice of coming back to the breath, again and again, kicks the prefrontal cortex into high gear and quiets the stress and craving centers of your brain . 3. Notice how it feels to breathe, and notice how the mind wanders. After a few minutes, drop the labels “inhale/exhale.” Try focusing on just the feeling of breathing. You might notice the sensations of the breath flowing in and out of your nose and mouth. You might sense the belly or chest expanding as you breathe in, and deflating as you breathe out. Your mind might wander a bit more without the labeling. Just as before, when you notice yourself thinking about something else, bring your attention back to the breath. If you need help refocusing, bring yourself back to the breath by saying “inhale” and “exhale” for a few rounds. This part of the practice trains self-awareness along with self-control. Start with five minutes a day. When this becomes a habit, try ten to fifteen minutes a day. If that starts to feel like a burden, bring it back down to five. A short practice that you do every day is better than a long practice you keep putting off to tomorrow. It may help you to pick a specific time that you will meditate every day, like right before your morning shower. If this is impossible, staying flexible will help you fit it in when you can.

We live in a world of illusions. We think we’re aware of everything going on around us. We look out and see an uninterrupted, complete picture of the visual world, composed of thousands of little detailed images. We may know that each of us has a blind spot, but we go on day to day blissfully unaware of where it actually is because our occipital cortex does such a good job of filling in the missing information and hence hiding it from us. Laboratory demonstrations of inattentional blindness (like the gorilla video of the last chapter) underscore how little of the world we actually perceive, in spite of the overwhelming feeling that we’re getting it all.

The right nostril is a gas pedal. When you’re inhaling primarily through this channel, circulation speeds up, your body gets hotter, and cortisol levels, blood pressure, and heart rate all increase. This happens because breathing through the right side of the nose activates the sympathetic nervous system, the “fight or flight” mechanism that puts the body in a more elevated state of alertness and readiness. Breathing through the right nostril will also feed more blood to the opposite hemisphere of the brain, specifically to the prefrontal cortex, which has been associated with logical decisions, language, and computing. Inhaling through the left nostril has the opposite effect: it works as a kind of brake system to the right nostril’s accelerator. The left nostril is more deeply connected to the parasympathetic nervous system, the rest-and-relax side that lowers blood pressure, cools the body, and reduces anxiety. Left-nostril breathing shifts blood flow to the opposite side of the prefrontal cortex, to the area that influences creative thought and plays a role in the formation of mental abstractions and the production of negative emotions.

You can see the proof in an MRI scan of someone presented with political opinions that conflict with her own. The brain scans of a person shown statements that oppose her political stance show that the highest areas of the cortex, the portions responsible for providing rational thought, get less blood until another statement is presented that confirms her beliefs. Your brain literally begins to shut down when you feel your ideology is threatened. Try it yourself. Watch a pundit you hate for fifteen minutes. Resist the urge to change the channel. Don’t complain to the person next to you. Don’t get online and rant. Try to let it go. You will find this is excruciatingly difficult.

Stolen Moments What happened, happened once. So now it’s best in memory—an orange he sliced: the skin unbroken, then the knife, the chilled wedge lifted to my mouth, his mouth, the thin membrane between us, the exquisite orange, tongue, orange, my nakedness and his, the way he pushed me up against the fridge— Now I get to feel his hands again, the kiss that didn’t last, but sent some neural twin flashing wildly through the cortex. Love’s merciless, the way it travels in and keeps emitting light. Beside the stove we ate an orange. And there were purple flowers on the table. And we still had hours. Kim Addonizio, What Is This Thing Called Love: Poems. (W. W. Norton & Company; unknown edition, August 17, 2005)

I once read that if the folds in the cerebral cortex were smoothed out it would cover a card table. That seemed quite unbelievable but it did make me wonder just how big the cortex would be if you ironed it out. I thought it might just about cover a family-sized pizza: not bad, but no card-table. I was astonished to realize that nobody seems to know the answer. A quick search yielded the following estimates for the smoothed out dimensions of the cerebral cortex of the human brain. An article in Bioscience in November 1987 by Julie Ann Miller claimed the cortex was a "quarter-metre square." That is napkin-sized, about ten inches by ten inches. Scientific American magazine in September 1992 upped the ante considerably with an estimated of 1 1/2 square metres; thats a square of brain forty inches on each side, getting close to the card-table estimate. A psychologist at the University of Toronto figured it would cover the floor of his living room (I haven't seen his living room), but the prize winning estimate so far is from the British magazine New Scientist's poster of the brain published in 1993 which claimed that the cerebral cortex, if flattened out, would cover a tennis court. How can there be such disagreement? How can so many experts not know how big the cortex is? I don't know, but I'm on the hunt for an expert who will say the cortex, when fully spread out, will cover a football field. A Canadian football field.

The language we speak, the beliefs we hold-both good and bad-are passed from generation to generation through experience. And so many aspects of the human experience are invented-as opposed to simply springing up from our genes. Ten thousand years ago, humankind had the genetic potential to read a book, yet not one single human on the planet could read; the genetic potential to play the piano existed, yet not one person could play; the genetic potential to dunk a basketball, type a sentence, ride a bicycle-all that potential existed, but it all remained unexpressed. Humankind, more than any other species, can take the accumulated, distilled experiences of previous generations and pass these inventions, beliefs, and skills to the next generation. This is sociocultural evolution. We learn from our elders, and we invent, and we pass what we’ve learned and invented to the next generations. And the organ that allows this is the human brain-specifically, the cortex. As we’ve said before, the cortex is the most uniquely human part of our body, and, no surprise, it gives rise to the most uniquely human capabilities: speech, language, abstract thinking, reflecting on the past, planning for the future. Our hopes, dreams, and a major part of our worldview are mediated by our cortex.

Cannabis affects the brain because brain cells themselves produce cannabis-like neurotransmitters. The first such compound to be identified was christened anandamide, ananda being Sanskrit for “bliss.” The proteins that transmit anandamide’s message to the brain, the receptors, are mainly located in the striatum (hence the blissful feeling) and in the cerebellum (hence the unsteady gait after taking marijuana), in the cerebral cortex (hence the problems with association, the fragmented thoughts and confusion), and in the hippocampus (hence the memory impairment). But there are no receptors in the brain stem areas that regulate blood pressure and breathing. That’s why it’s impossible to take an overdose of cannabis, as opposed to opiates.

Brain scans prove that patients who’ve sustained significant childhood trauma have brains that look different from people who haven’t. Traumatized brains tend to have an enlarged amygdala—a part of the brain that is generally associated with producing feelings of fear. Which makes sense. But it goes further than that: For survivors of emotional abuse, the part of their brain that is associated with self-awareness and self-evaluation is shrunken and thin. Women who’ve suffered childhood sexual abuse have smaller somatosensory cortices—the part of the brain that registers sensation in our bodies. Victims who were screamed at might have an altered response to sound. Traumatized brains can result in reductions in the parts of the brain that process semantics, emotion and memory retrieval, perceiving emotions in others, and attention and speech. Not getting enough sleep at night potentially affects developing brains’ plasticity and attention and increases the risk of emotional problems later in life. And the scariest factoid, for me anyway: Child abuse is often associated with reduced thickness in the prefrontal cortex, the part of the brain associated with moderation, decision-making, complex thought, and logical reasoning. Brains do have workarounds. There are people without amygdalae who don’t feel fear. There are people who have reduced prefrontal cortices who are very logical. And other parts of the brain can compensate, make up the lost parts in other ways. But overall, when I looked at the breadth of evidence, the results felt crushing. The fact that the brain’s cortical thickness is directly related to IQ was particularly threatening to me. Even if I wasn’t cool, or kind, or personable, I enjoyed the narrative that I was at least effective. Intelligent. What these papers seemed to tell me is that however smart I am, I’m not as smart as I could have been had this not happened to me. The questions arose again: Is this why my pitches didn’t go through? Is this why my boss never respected me? Is this why I was pushed to do grunt work in the back room?

Most people don't see half of what's in front of them. Your visual cortex does a shit load of imaging processing before the signal even gets to your brain, whose priorities are still checking the ancestral Savannah for dangerous predators, edible berries and climable trees. That's why a sudden cat in the night can make you jump and some people when distracted, can walk right out in front of a bus. Your brain just isn't interested in those large moving chunks of metal or the static heaps of brightly colored stuff that piles up in drifts around us. Never mind all that, says your brain, it's those silent fur-covered merchants of death you've got to watch out for.

Since then neuroscience research has shown that we possess two distinct forms of self-awareness: one that keeps track of the self across time and one that registers the self in the present moment. The first, our autobiographical self, creates connections among experiences and assembles them into a coherent story. This system is rooted in language. Our narratives change with the telling, as our perspective changes and as we incorporate new input. The other system, moment-to-moment self-awareness, is based primarily in physical sensations, but if we feel safe and are not rushed, we can find words to communicate that experience as well. These two ways of knowing are localized in different parts of the brain that are largely disconnected from each other.10 Only the system devoted to self-awareness, which is based in the medial prefrontal cortex, can change the emotional brain. In the groups I used to lead for veterans, I could sometimes see these two systems working side by side. The soldiers told horrible tales of death and destruction, but I noticed that their bodies often simultaneously radiated a sense of pride and belonging.

Work by Martha Farah of the University of Pennsylvania, Tom Boyce of UCSF, and others demonstrates something outrageous: By age five, the lower a child’s socioeconomic status, on the average, the (a) higher the basal glucocorticoid levels and/or the more reactive the glucocorticoid stress response, (b) the thinner the frontal cortex and the lower its metabolism, and (c) the poorer the frontal function concerning working memory, emotion regulation, impulse control, and executive decision making; moreover, to achieve equivalent frontal regulation, lower-SES kids must activate more frontal cortex than do higher-SES kids. In addition, childhood poverty impairs maturation of the corpus callosum, a bundle of axonal fibers connecting the two hemispheres and integrating their function. This is so wrong—foolishly pick a poor family to be born into, and by kindergarten, the odds of your succeeding at life’s marshmallow tests are already stacked against you.34

Throughout the human life span there remains a constant two-way interaction between psychological states and the neurochemistry of the frontal lobes, a fact that many doctors do not pay enough attention to. One result is the overreliance on medications in the treatment of mental disorders. Modern psychiatry is doing too much listening to Prozac and not enough listening to human beings; people’s life histories should be given at least as much importance as the chemistry of their brains. The dominant tendency is to explain mental conditions by deficiencies of the brain’s chemical messengers, the neurotransmitters. As Daniel J. Siegel has sharply remarked, “We hear it said everywhere these days that the experience of human beings comes from their chemicals.” Depression, according to the simple biochemical model, is due to a lack of serotonin — and, it is said, so is excessive aggression. The answer is Prozac, which increases serotonin levels in the brain. Attention deficit is thought to be due in part to an undersupply of dopamine, one of the brain’s most important neurotransmitters, crucial to attention and to experiencing reward states. The answer is Ritalin. Just as Prozac elevates serotonin levels, Ritalin or other psychostimulants are thought to increase the availability of dopamine in the brain’s prefrontal areas. This is believed to increase motivation and attention by improving the functioning of areas in the prefrontal cortex. Although they carry some truth, such biochemical explanations of complex mental states are dangerous oversimplifications — as the neurologist Antonio Damasio cautions: "When it comes to explaining behavior and mind, it is not enough to mention neurochemistry... The problem is that it is not the absence or low amount of serotonin per se that “causes” certain manifestations. Serotonin is part of an exceedingly complicated mechanism which operates at the level of molecules, synapses, local circuits, and systems, and in which sociocultural factors, past and present, also intervene powerfully. The deficiencies and imbalances of brain chemicals are as much effect as cause. They are greatly influenced by emotional experiences. Some experiences deplete the supply of neurotransmitters; other experiences enhance them. In turn, the availability — or lack of availability — of brain chemicals can promote certain behaviors and emotional responses and inhibit others. Once more we see that the relationship between behavior and biology is not a one-way street.

The cortex craves for information, but it can longer contain and creatively process it all. How can a body subjectively and simultaneous grasp both nanoseconds and nebulae? THE CORTEX THAT CANNOT COPE RESORTS TO SPECIALIZATION. Specialization, once a maneuver methodically to collect information, now is a manifestation of information overloads. The role of information has changed. Once justified as a means of comprehending the world, it now generates a conflicting and contradictory, fleeting and fragmentation field of disconnected and undigested data. INFORMATION IS RADIATION. The most significant planetary pressure is no longer the gravitational pull, but the information thrust. The psycho-social flowering of the human species has withered. We are in the twilight of our cerebral fantasies. The symbol has lost all power. The accumulation of information has lost all purpose. Memory results in mimicry. Reflection will not suffice. THE BODY MUST BURST FROM ITS BIOLOGICAL, CULTURAL, AND PLANETARY CONTAINMENT.

Our visual field, the entire view of what we can see when we look out into the world, is divided into billions of tiny spots or pixels. Each pixel is filled with atoms and molecules that are in vibration. The retinal cells in the back of our eyes detect the movement of those atomic particles. Atoms vibrating at different frequencies emit different wavelengths of energy, and this information is eventually coded as different colors by the visual cortex in the occipital region of our brain. A visual image is built by our brain's ability to package groups of pixels together in the form of edges. Different edges with different orientations - vertical, horizontal and oblique, combine to form complex images. Different groups of cells in our brain add depth, color and motion to what we see.

Environmental influences also affect dopamine. From animal studies, we know that social stimulation is necessary for the growth of the nerve endings that release dopamine and for the growth of receptors that dopamine needs to bind to in order to do its work. In four-month-old monkeys, major alterations of dopamine and other neurotransmitter systems were found after only six days of separation from their mothers. “In these experiments,” writes Steven Dubovsky, Professor of Psychiatry and Medicine at the University of Colorado, “loss of an important attachment appears to lead to less of an important neurotransmitter in the brain. Once these circuits stop functioning normally, it becomes more and more difficult to activate the mind.” A neuroscientific study published in 1998 showed that adult rats whose mothers had given them more licking, grooming and other physical-emotional contact during infancy had more efficient brain circuitry for reducing anxiety, as well as more receptors on nerve cells for the brain’s own natural tranquilizing chemicals. In other words, early interactions with the mother shaped the adult rat’s neurophysiological capacity to respond to stress. In another study, newborn animals reared in isolation had reduced dopamine activity in their prefrontal cortex — but not in other areas of the brain. That is, emotional stress particularly affects the chemistry of the prefrontal cortex, the center for selective attention, motivation and self-regulation. Given the relative complexity of human emotional interactions, the influence of the infant-parent relationship on human neurochemistry is bound to be even stronger. In the human infant, the growth of dopamine-rich nerve terminals and the development of dopamine receptors is stimulated by chemicals released in the brain during the experience of joy, the ecstatic joy that comes from the perfectly attuned mother-child mutual gaze interaction. Happy interactions between mother and infant generate motivation and arousal by activating cells in the midbrain that release endorphins, thereby inducing in the infant a joyful, exhilarated state. They also trigger the release of dopamine. Both endorphins and dopamine promote the development of new connections in the prefrontal cortex. Dopamine released from the midbrain also triggers the growth of nerve cells and blood vessels in the right prefrontal cortex and promotes the growth of dopamine receptors. A relative scarcity of such receptors and blood supply is thought to be one of the major physiological dimensions of ADD. The letters ADD may equally well stand for Attunement Deficit Disorder.

A neurosurgeon once told me about operating on the brain of a young man with epilepsy. As is customary in this kind of operation, the patient was wide awake, under only local anesthesia, while the surgeon delicately explored his exposed cortex, makingsure that the parts tentatively to be removed were not absolutely vital by stimulating them electrically and asking the patient what he experienced. Some stimulations provoked visual flashes or hand-raisings, others a sort of buzzing sensation, but one spot produced a delighted response from the patient: "It's 'Outta Get Me' by Guns N' Roses. my favorite heavy metal band!" I asked the neurosurgeon If he had asked the patient to sing or hum along with the music, since it would be fascinating to learn how "high fidelity" the provoked memory was, would it be in exactly the same key and tempo as the record? Such a song (unliken"Silent Night") has one canonical version. so we could simply have superimposed a recording of the patients humming with the standard record and compared the results. Unfortunately, even though a tape recorder had been running during the operation, thesurgeon hadn't asked the patient to sing along. ''Why not?" I asked, and he replied: "I hate rock music!' Later in the conversation the neurosurgeon happened to remark that he was going to have to operate again on the same young man. and I expressed the hope that he would just check to see if he could restimulate the rock music, and this time ask the fellow to sing along. "I can't do it." replied the neurosurgeon. "since I cut out that part." "It was part of the epileptic focus?" I asked. "No,'' the surgeon replied, ''I already told you — I hate rock music.

efficiently means providing slots in our schedules where we can maintain an attentional set for an extended period. This allows us to get more done and finish up with more energy. Related to the manager/worker distinction is that the prefrontal cortex contains circuits responsible for telling us whether we’re controlling something or someone else is. When we set up a system, this part of the brain marks it as self-generated. When we step into someone else’s system, the brain marks it that way. This may help explain why it’s easier to stick with an exercise program or diet that someone else sets up: We typically trust them as “experts” more than we trust ourselves. “My trainer told me to do three sets of ten reps at forty pounds—he’s a trainer, he must know what he’s talking about. I can’t design my own workout—what do I know?” It takes Herculean amounts of discipline to overcome the brain’s bias against self-generated motivational systems. Why? Because as with the fundamental attribution error we saw in Chapter 4, we don’t have access to others’ minds, only our own. We are painfully aware of all the fretting and indecision, all the nuances of our internal decision-making process that led us to reach a particular conclusion. (I really need to get serious about exercise.) We don’t have access to that (largely internal) process in others, so we tend to take their certainty as more compelling, in many cases, than our own. (Here’s your program. Do it every day.)

These computer simulations try only to duplicate the interactions between the cortex and the thalamus. Huge chunks of the brain are therefore missing. Dr. [Dharmendra] Modha understands the enormity of his project. His ambitious research has allowed him to estimate what it would take to create a working model of the entire human brain, and not just a portion or a pale version of it, complete with all parts of the neocortex and connections to the senses. He envisions using not just a single Blue Gene computer [with over a hundred thousand processors and terabytes of RAM] but thousands of them, which would fill up not just a room but an entire city block. The energy consumption would be so great that you would need a thousand-megawatt nuclear power plant to generate all the electricity. And then, to cool off this monstrous computer so it wouldn't melt, you would need to divert a river and send it through the computer circuits. It is remarkable that a gigantic, city-size computer is required to simulate a piece of human tissue that weighs three pounds, fits inside your skull, raises your body temperature by only a few degrees, uses twenty watts of power, and needs only a few hamburgers to keep it going.

When you walked through a park, the immersive world that surrounded you was something that existed inside your own brain as a pattern of neurons firing. The sensation of a bright blue sky wasn't something high above you, it was something in your visual cortex, and your visual cortex was in the back of your brain. All the sensations of that bright world were really happening in that quiet cave of bone you called your skull, the place where you lived and never, ever left. If you really wanted to say hello to someone, to the actual person, you wouldn't shake their hand, you'd knock gently on their skull and say "How are you doing in there?" That was what people were, that was where they really lived. And the picture of the park that you thought you were walking through was something that was visualized inside your brain as it processed the signals sent down from your eyes and retina. It wasn't a lie like the Buddhists thought, there wasn't something terribly mystical and unexpected behind the veil of Maya, what lay beyond the illusion of the park was just the actual park, but it was all still illusion.

Imperial is like Robert Caro’s The Power Broker with the attitude of Mike Davis’s City of Quartz, if Robert Caro had been raised in an abandoned grain silo by a band of feral raccoons, and if Mike Davis were the communications director of a heavily armed libertarian survivalist cult, and if the two of them had somehow managed to stitch John McPhee’s cortex onto the brain of a Gila monster, which they then sent to the Mexican border to conduct ten years of immersive research, and also if they wrote the entire manuscript on dried banana leaves with a toucan beak dipped in hobo blood, and then the book was line-edited during a 36-hour peyote séance by the ghosts of John Steinbeck, Jack London, and Sinclair Lewis, with 200 pages of endnotes faxed over by Henry David Thoreau’s great-great-great-great grandson from a concrete bunker under a toxic pond behind a maquiladora, and if at the last minute Herman Melville threw up all over the manuscript, rendering it illegible, so it had to be re-created from memory by a community-theater actor doing his best impression of Jack Kerouac. With photographs by Dorothea Lange. (Viking has my full blessing to use that as a blurb.)

A person’s average or typical level of happiness is that person’s “affective style.” (“Affect” refers to the felt or experienced part of emotion.) Your affective style reflects the everyday balance of power between your approach system and your withdrawal system, and this balance can be read right from your forehead. It has long been known from studies of brainwaves that most people show an asymmetry: more activity either in the right frontal cortex or in the left frontal cortex. In the late 1980s, Richard Davidson at the University of Wisconsin discovered that these asymmetries correlated with a person’s general tendencies to experience positive and negative emotions. People showing more of a certain kind of brainwave coming through the left side of the forehead reported feeling more happiness in their daily lives and less fear, anxiety, and shame than people exhibiting higher activity on the right side. Later research showed that these cortical “lefties” are less subject to depression and recover more quickly from negative experiences.29 The difference between cortical righties and lefties can be seen even in infants: Ten-month-old babies showing more activity on the right side are more likely to cry when separated briefly from their mothers.30 And this difference in infancy appears to reflect an aspect of personality that is stable, for most people, all the way through adulthood. 31 Babies who show a lot more activity on the right side of the forehead become toddlers who are more anxious about novel situations; as teenagers, they are more likely to be fearful about dating and social activities; and, finally, as adults, they are more likely to need psychotherapy to loosen up.

Suppose you unexpectedly see a person you care about. Suddenly you feel the love you have, for that person. Let's follow the flow of information from the visual system through the brain to the point of the experience of love as best we can. First of all, the stimulus will flow from the visual system to the prefrontal cortex (putting an image of the loved one in working memory). The stimulus also reaches the explicit memory system of the temporal lobe and activates memories and integrates them with the image of the person. Simultaneously with these processes, the subcortical areas presumed to be involved in attachment will be activated (the exact paths by which the stimulus reaches these areas is not known, however). Activation of attachment circuits then impacts on working memory in several ways. One involves direct connections from the attachment areas to the prefrontal cortex (as with fear, it is the medial prefrontal region that is connected with subcortical attachment areas). Activation of attachment circuits also leads to activation of brain stem arousal networks, which then participate in the focusing of attention on the loved one by working memory. Bodily responses will also be initiated as outputs of attachment circuits, and contrast with the alarm responses initiated by fear and stress circuits. We approach rather than try to escape from or avoid the person, and these behavioral differences are accompanied by different physiological conditions within the body. This pattern of inputs to working memory from within the brain and from the body biases us more toward an open and accepting mode of processing than toward tension and vigilance. The net result in working memory is the feeling of love.

If you are one of those people who can’t hold a lot in mind at once—you lose focus and start daydreaming in lectures, and have to get to someplace quiet to focus so you can use your working memory to its maximum—well, welcome to the clan of the creative. Having a somewhat smaller working memory means you can more easily generalize your learning into new, more creative combinations. Because you’re learning new, more creative combinations. Having a somewhat smaller working memory, which grows from the focusing abilities of the prefrontal cortex, doesn’t lock everything up so tightly, you can more easily get input from other parts of your brain. These other areas, which include the sensory cortex, not only are more in tune with what’s going on in the environment, but also are the source of dreams, not to mention creative ideas. You may have to work harder sometimes (or even much of the time) to understand what’s going on, but once you’ve got something chunked, you can take that chunk and turn it outside in and inside round—putting it through creative paces even you didn’t think you were capable of! Here’s another point to put into your mental chunker: Chess, that bastion of intellectuals, has some elite players with roughly average IQs. These seemingly middling intellects are able to do better than some more intelligent players because they practice more. That’s the key idea. Every chess player, whether average or elite, grows talent by practicing. It is the practice—particularly deliberate practice on the toughest aspects of the material—that can help lift average brains into the realm of those with more “natural” gifts. Just as you can practice lifting weights and get bigger muscles over time, you can also practice certain mental patterns that deepen and enlarge in your mind.

But young children, whose prefrontal cortexes have barely begun to ripen, can’t conceive of a future, which means they spend their lives in the permanent present, a forever feeling of right now. At times, this is a desirable state of consciousness; indeed, for meditators, it’s the ultimate aspiration. But living in the permanent present is not a practical parenting strategy. “Everybody would like to be in the present,” says Daniel Gilbert, a social psychologist at Harvard and author of the 2006 best-seller Stumbling on Happiness. “Certainly it’s true that there is an important role for being present in our lives. All the data say that. My own research says that.” The difference is that children, by definition, only live in the present, which means that you, as a parent, don’t get much of a chance. “Everyone is moving at the same speed toward the future,” he says. “But your children are moving at that same speed with their eyes closed. So you’re the ones who’ve got to steer.” He thinks about this for a moment. “You know, back in the early seventies, I hung out with a lot of people who wanted to live in the present. And it meant that no one paid the rent.” In effect, parents and small children have two completely different temporal outlooks. Parents can project into the future; their young children, anchored in the present, have a much harder time of it. This difference can be a formula for heartbreak for a small child.

Oh I'll die I'll die I'll die My skin is in blazing furore I do not know what I'll do where I'll go oh I am sick I'll kick all Arts in the butt and go away Shubha Shubha let me go and live in your cloaked melon In the unfastened shadow of dark destroyed saffron curtain The last anchor is leaving me after I got the other anchors lifted I can't resist anymore, a million glass panes are breaking in my cortex I know, Shubha, spread out your matrix, give me peace Each vein is carrying a stream of tears up to the heart Brain's contagious flints are decomposing out of eternal sickness other why didn't you give me birth in the form of a skeleton I'd have gone two billion light years and kissed God's ass But nothing pleases me nothing sounds well I feel nauseated with more than a single kiss I've forgotten women during copulation and returned to the Muse In to the sun-coloured bladder I do not know what these happenings are but they are occurring within me I'll destroy and shatter everything draw and elevate Shubha in to my hunger Shubha will have to be given Oh Malay Kolkata seems to be a procession of wet and slippery organs today But i do not know what I'll do now with my own self My power of recollection is withering away Let me ascend alone toward death I haven't had to learn copulation and dying I haven't had to learn the responsibility of shedding the last drops after urination Haven't had to learn to go and lie beside Shubha in the darkness Have not had to learn the usage of French leather while lying on Nandita's bosom Though I wanted the healthy spirit of Aleya's fresh China-rose matrix Yet I submitted to the refuge of my brain's cataclysm I am failing to understand why I still want to live I am thinking of my debauched Sabarna-Choudhury ancestors I'll have to do something different and new Let me sleep for the last time on a bed soft as the skin of Shubha's bosom I remember now the sharp-edged radiance of the moment I was born I want to see my own death before passing away The world had nothing to do with Malay Roychoudhury Shubha let me sleep for a few moments in your violent silvery uterus Give me peace, Shubha, let me have peace Let my sin-driven skeleton be washed anew in your seasonal bloodstream Let me create myself in your womb with my own sperm Would I have been like this if I had different parents? Was Malay alias me possible from an absolutely different sperm? Would I have been Malay in the womb of other women of my father? Would I have made a professional gentleman of me like my dead brother without Shubha? Oh, answer, let somebody answer these Shubha, ah Shubha Let me see the earth through your cellophane hymen Come back on the green mattress again As cathode rays are sucked up with the warmth of a magnet's brilliance I remember the letter of the final decision of 1956 The surroundings of your clitoris were being embellished with coon at that time Fine rib-smashing roots were descending in to your bosom Stupid relationship inflated in the bypass of senseless neglect Aaaaaaaaaaaaaaaaaaaaaaaah I do not know whether I am going to die Squandering was roaring within heart's exhaustive impatience I'll disrupt and destroy I'll split all in to pieces for the sake of Art There isn't any other way out for Poetry except suicide Shubha Let me enter in to the immemorial incontinence of your labia majora In to the absurdity of woeless effort In the golden chlorophyll of the drunken heart Why wasn't I lost in my mother's urethra? Why wasn't I driven away in my father's urine after his self-coition? Why wasn't I mixed in the ovum -flux or in the phlegm? With her eyes shut supine beneath me I felt terribly distressed when I saw comfort seize S

So which theory did Lagos believe in? The relativist or the universalist?" "He did not seem to think there was much of a difference. In the end, they are both somewhat mystical. Lagos believed that both schools of thought had essentially arrived at the same place by different lines of reasoning." "But it seems to me there is a key difference," Hiro says. "The universalists think that we are determined by the prepatterned structure of our brains -- the pathways in the cortex. The relativists don't believe that we have any limits." "Lagos modified the strict Chomskyan theory by supposing that learning a language is like blowing code into PROMs -- an analogy that I cannot interpret." "The analogy is clear. PROMs are Programmable Read-Only Memory chips," Hiro says. "When they come from the factory, they have no content. Once and only once, you can place information into those chips and then freeze it -- the information, the software, becomes frozen into the chip -- it transmutes into hardware. After you have blown the code into the PROMs, you can read it out, but you can't write to them anymore. So Lagos was trying to say that the newborn human brain has no structure -- as the relativists would have it -- and that as the child learns a language, the developing brain structures itself accordingly, the language gets 'blown into the hardware and becomes a permanent part of the brain's deep structure -- as the universalists would have it." "Yes. This was his interpretation." "Okay. So when he talked about Enki being a real person with magical powers, what he meant was that Enki somehow understood the connection between language and the brain, knew how to manipulate it. The same way that a hacker, knowing the secrets of a computer system, can write code to control it -- digital namshubs?" "Lagos said that Enki had the ability to ascend into the universe of language and see it before his eyes. Much as humans go into the Metaverse. That gave him power to create nam-shubs. And nam-shubs had the power to alter the functioning of the brain and of the body." "Why isn't anyone doing this kind of thing nowadays? Why aren't there any namshubs in English?" "Not all languages are the same, as Steiner points out. Some languages are better at metaphor than others. Hebrew, Aramaic, Greek, and Chinese lend themselves to word play and have achieved a lasting grip on reality: Palestine had Qiryat Sefer, the 'City of the Letter,' and Syria had Byblos, the 'Town of the Book.' By contrast other civilizations seem 'speechless' or at least, as may have been the case in Egypt, not entirely cognizant of the creative and transformational powers of language. Lagos believed that Sumerian was an extraordinarily powerful language -- at least it was in Sumer five thousand years ago." "A language that lent itself to Enki's neurolinguistic hacking." "Early linguists, as well as the Kabbalists, believed in a fictional language called the tongue of Eden, the language of Adam. It enabled all men to understand each other, to communicate without misunderstanding. It was the language of the Logos, the moment when God created the world by speaking a word. In the tongue of Eden, naming a thing was the same as creating it. To quote Steiner again, 'Our speech interposes itself between apprehension and truth like a dusty pane or warped mirror. The tongue of Eden was like a flawless glass; a light of total understanding streamed through it. Thus Babel was a second Fall.' And Isaac the Blind, an early Kabbalist, said that, to quote Gershom Scholem's translation, 'The speech of men is connected with divine speech and all language whether heavenly or human derives from one source: the Divine Name.' The practical Kabbalists, the sorcerers, bore the title Ba'al Shem, meaning 'master of the divine name.'" "The machine language of the world," Hiro says.