Clinical Trial Game Quotes

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On the one hand, I recognize the power of the placebo effect: if you believe it’s working, it may well work. If you think an object brings you luck, you are more confident. And yet what the Italian students in the “lucky” seats showed wasn’t confidence; it was overconfidence. They thought they were doing better, but the evidence didn’t actually back them up. And then there’s the flip side of the placebo, the nocebo effect: the belief in evil signs or bad luck. It turns out people can literally scare themselves to death. If you think you’ve been cursed or otherwise made ill, you may end up actually getting sick, failing to improve poor health, or, yes, dying altogether. In one medically documented instance, a man was given three months to live after a diagnosis of metastatic cancer of the esophagus. He died shortly after. When his body was autopsied, doctors realized that he had been misdiagnosed: he did indeed have cancer, but a tiny, non-metastatic tumor on his liver. Clinically speaking, it could not have killed him. But, it seems, being told he was dying of a fatal illness brought about that very outcome. In another case, a man thought he was hexed by a voodoo priest. He came close to death, only to recover miraculously after an enterprising doctor “reversed” the curse through a series of made-up words. In yet a third, a man almost died in the emergency room after overdosing on pills. He’d been in a drug trial for depression and decided to end his life with the antidepressants he’d been prescribed. His vitals were so bad when he was admitted that doctors didn’t think he would make it—until they discovered his blood was completely clear of any drugs. He’d been taking a placebo. Once he found out he had not in fact taken a life-threatening quantity of pills, he recovered quickly. The effect our mind has on our body makes for a scary proposition. Belief is a powerful thing. Our mental state is crucial to our performance. And ultimately, while some superstitions may give you a veneer of false confidence, they also have the power to destroy your mental equilibrium. I like to think of this as the black cat effect. You see one cross the parking lot as you walk to a tournament. You brood about the bad luck. Your game is thrown off. You blame the cat. You bust. You feel validated. Superstitions are false attributions, so they give you a false sense of your own abilities and in the end, impede learning.
Maria Konnikova (The Biggest Bluff: How I Learned to Pay Attention, Master Myself, and Win)
TO REDUCE APPETITE, PROMOTE FAT LOSS, AND REBALANCE OUR METABOLISM: The peptide semaglutide (and other glucagon-like peptide-1 agonists) have aced four-year-plus clinical trials, with subjects routinely losing 15 percent of their body weight—or 30 pounds for someone weighing in at 200. Generally well-tolerated, with a terrific safety profile, GLP-1s can be game-changers when added to a healthy diet, exercise, and other lifestyle changes. Occasional side effects: nausea, diarrhea, and flatulence. May not be suitable for individuals with a history of thyroid gland tumors. MOTS-c and Humanin are derived from the mitochondria, our cells’ power packs. Among other things, they may revitalize our carbohydrate and fat metabolism. This category of mitochondrial peptides is a potential wellspring of future innovation for longevity, healthspan, and peak performance!
Tony Robbins (Life Force: How New Breakthroughs in Precision Medicine Can Transform the Quality of Your Life & Those You Love)