Cell Membrane Quotes

I penetrated the outer cell membrane with a nanosyringe." "You poked it with a stick?" "No!" I said. "Well. Yes. But it was a scientific poke with a very scientific stick.

To live is to be vulnerable. A thin membrane of a soap bubble separates one from impenetrable hell. Ice on the road. The unlucky division of an aging cell. A child picks up a pill from the floor. Words stick to each other, line up, obedient to the great harmony of speech...

I penetrated the outer cell membrane with a nanosyringe.” “You poked it with a stick?” “No!” I said. “Well. Yes. But it was a scientific poke with a very scientific stick.

How did you do it? What killed it?” “I penetrated the outer cell membrane with a nanosyringe.” “You poked it with a stick?” “No!” I said. “Well. Yes. But it was a scientific poke with a very scientific stick.” “It took you two days to think of poking it with a stick.” “You…be quiet.

Say the planet is born at midnight and it runs for one day. First there is nothing. Two hours are lost to lava and meteors. Life doesn’t show up until three or four a.m. Even then, it’s just the barest self-copying bits and pieces. From dawn to late morning—a million million years of branching—nothing more exists than lean and simple cells. Then there is everything. Something wild happens, not long after noon. One kind of simple cell enslaves a couple of others. Nuclei get membranes. Cells evolve organelles. What was once a solo campsite grows into a town. The day is two-thirds done when animals and plants part ways. And still life is only single cells. Dusk falls before compound life takes hold. Every large living thing is a latecomer, showing up after dark. Nine p.m. brings jellyfish and worms. Later that hour comes the breakout—backbones, cartilage, an explosion of body forms. From one instant to the next, countless new stems and twigs in the spreading crown burst open and run. Plants make it up on land just before ten. Then insects, who instantly take to the air. Moments later, tetrapods crawl up from the tidal muck, carrying around on their skin and in their guts whole worlds of earlier creatures. By eleven, dinosaurs have shot their bolt, leaving the mammals and birds in charge for an hour. Somewhere in that last sixty minutes, high up in the phylogenetic canopy, life grows aware. Creatures start to speculate. Animals start teaching their children about the past and the future. Animals learn to hold rituals. Anatomically modern man shows up four seconds before midnight. The first cave paintings appear three seconds later. And in a thousandth of a click of the second hand, life solves the mystery of DNA and starts to map the tree of life itself. By midnight, most of the globe is converted to row crops for the care and feeding of one species. And that’s when the tree of life becomes something else again. That’s when the giant trunk starts to teeter.

For one thing, the river that flows ever onwards is also seeping sideways, irrigating the fields and land to one side and the other. It finds its way into wells and is drawn up to launder petticoats and be boiled for tea. It is sucked into root membranes, travels up cell by cell to the surface, is held in the leaves of watercress

How did you do it? What killed it?” “I penetrated the outer cell membrane with a nanosyringe.” “You poked it with a stick?” “No!” I said. “Well. Yes. But it was a scientific poke with a very scientific stick.

JAY: No really. Be secure. Pretend I'm a sperm cell. Here. I take the string out of the... hood of my sweatshirt, affix it to my behind for a tail, like so... LENORE: What in God's name are you doing? JAY: Pretend, Lenore. Be an ovum. Be strong. Let me hypothetically batter at you. Batter batter. Surrender to the unreal of the real interior. LENORE: Are you supposed to be a sperm, wriggling your sweatshirt-string like that? JAY: I can feel the strength of your membrane, Lenore.

Food isn’t just generic energy—it’s molecular information. In addition to fueling the mitochondrial powerhouses, food tells our cells what to do and serves as building blocks for hormones, brain chemicals, and cell membranes.

Phosphatidylserine is a natural constituent of the cell membrane but is found in especially high concentrations in the brain. Supplementing with phosphatidylserine slows down memory loss and has been shown to reverse memory loss in some patients with age-related memory decline. It also lowers levels of cortisol, a principal hormone of aging.

Because cells are surrounded with a lipid membrane, essential oils are attracted to and able to penetrate the cell membrane to deliver nutrients to the cell nucleus.[103],[104],[105],[106],[107] This suggests that essential oils can affect cell function and behavior, thus influencing overall well-being. At the same time, the aroma of the essential oil that is inhaled travels to the limbic system where a cascade of psychophysiological effects is triggered in response.

How can we account for long-term memory”, van Lommel asks, “if the molecular makeup of the cell membrane of neurons is completely renewed every two weeks and the millions of synapses in the brain undergo a process of constant adaptation?”15

it is illusion to think that there is anything fragile about the life of the earth; surely this is the toughest membrane imaginable in the universe, opaque to probability, impermeable to death. We are the delicate part, transient and vulnerable as cilia. Nor is it a new thing for Man to invent an existence that he imagines to be above the rest of life; this has been his most consistent intellectual exertion down the millennia. As illusion, it has never worked out to his satisfaction in the past, any more than it does today.

Substances contained in vaccines are able to alter or destroy membranes, which influences the mechanisms and duties they perform within the cell.

We had a photo of our child as a blastocyst, taken just before implantation. ("She has your cell membrane," I remarked to Lucy.)

We had a photo of our child as a blastocyst, taken just before implantation. (“She has your cell membrane,” I remarked to Lucy.)

I penetrated the outer cell membrane with a nanosyringe.” “You poked it with a stick?

What killed it?” “I penetrated the outer cell membrane with a nanosyringe.” “You poked it with a stick?” “No!” I said. “Well. Yes. But it was a scientific poke with a very scientific stick.

How did you do it? What killed it?” “I penetrated the outer cell membrane with a nanosyringe.” “You poked it with a stick?” “No!” I said. “Well. Yes. But it was a scientific poke with a very scientific stick.

school you may have learned the basic components of a cell: the nucleus that contains genetic material, the energy-producing mitochondria, the protective membrane at the outside rim, and the cytoplasm in between.

A cell has a nucleus and some other parts like membranes, plasmas and other stuff. Its energy is made up of protons, neurons and electrons. Genetic scientists, however, have discovered that the majority of a cell is made up of something unknown. Something akin to space filled with electromagnetic fibers of light. The human body is made up of some 37 trillion cells. What do you think you are made of? Who do you think you are?

The maestro of the orchestra of life is the genetic material which directs the proteins, sugars and minerals. It receives signals about the external environment, decides the speed and timing of the reactions and communicates this information to all cells. It breaks down sugars, clears waste, repairs the membrane and reproduces.

I penetrated the outer cell membrane with a nanosyringe.” “You poked it with a stick?” “No!” I said. “Well. Yes. But it was a scientific poke with a very scientific stick.” “It took you two days to think of poking it with a stick.” “You…be quiet.

I penetrated the outer cell membrane with a nanosyringe." "You poked it with a stick?" "No!" I said. "Well. Yes. But it was a scientific poke with a very scientific stick.” "It took you two days to think of poking it with a stick." "You... be quiet.

How did you do it? What killed it?” “I penetrated the outer cell membrane with a nanosyringe.” “You poked it with a stick?” “No!” I said. “Well. Yes. But it was a scientific poke with a very scientific stick.” “It took you two days to think of poking it with a stick.

All the early stages took place in water: the origin of life; the birth of animals, the evolution of nervous systems and brains, and the appearance of complex bodies that makes brains worth having [...] When animals did crawl onto dry land, they took the sea with them. All the basic activities of life occur in water-filled cells bounded by membranes, tiny containers whose insides are remnants of the sea.

The pituitary hormone prolactin, the same substance that stimulates milk flow in nursing mothers, seems to sensitize cells to electric current. Then the signal causes nearby cells to dedifferentiate and form a blastema, apparently by changing the way cell membranes pass calcium ions.

How did you do it? what killed it?" "I penetrated the outer cell membrane with a nanosyringe." "You poked it with a stick?" "No!" I said. "Well. Yes. But it was a scientific poke with a very scientific stick." "It took you two days to think of poking it with a stick." "You ... be quiet.

Similarly deadly to small wriggling cells, if a bit more quackish, is vanadium, element twenty-three, which also has a curious side effect in males: vanadium is the best spermicide ever devised. Most spermicides dissolve the fatty membrane that surrounds sperm cells, spilling their guts all over. Unfortunately, all cells have fatty membranes, so spermicides often irritate the lining of the vagina and make women susceptible to yeast infections. Not fun. Vanadium eschews any messy dissolving and simply cracks the crankshaft on the sperm’s tails. The tails then snap off, leaving

To avoid this infiltration the bacteria alter the permeability of their cell membranes, often by altering the structure of the doorways that let outside substances into the cell. This makes it harder, or impossible, for antibiotics to sneak in — essentially keeping the level of the drug below that needed to affect the bacteria.

Actually, the entire ascent of life can be presented as an adaptive radiation in the time dimension. From the beginning of replicating molecules to the formation of membrane-bounded cells, the formation of chromosomes, the origin of nucleated eukaryotes, the formation of multicellular organisms, the rise of endothermy, and the evolution of a large and highly complex central nervous system, each of these steps permitted the utilization of a different set of environmental resources, that is, the occupation of a different adaptive zone.

Influenza is caused by three types of viruses, of which the most worrisome and widespread is influenza A. Viruses of that type all share certain genetic traits: a single-stranded RNA genome, which is partitioned into eight segments, which serve as templates for eleven different proteins. In other words, they have eight discrete stretches of RNA coding, linked together like eight railroad cars, with eleven different deliverable cargoes. The eleven deliverables are the molecules that comprise the structure and functional machinery of the virus. They are what the genes make. Two of those molecules become spiky protuberances from the outer surface of the viral envelope: hemagglutinin and neuraminidase. Those two, recognizable by an immune system, and crucial for penetrating and exiting cells of a host, give the various subtypes of influenza A their definitive labels: H5N1, H1N1, and so on. The term “H5N1” indicates a virus featuring subtype 5 of the hemagglutinin protein combined with subtype 1 of the neuraminidase protein. Sixteen different kinds of hemagglutinin, plus nine kinds of neuraminidase, have been detected in the natural world. Hemagglutinin is the key that unlocks a cell membrane so that the virus can get in, and neuraminidase is the key for getting back out. Okay so far? Having absorbed this simple paragraph, you understand more about influenza than 99.9 percent of the people on Earth. Pat yourself on the back and get a flu shot in November. At

In Molecules of Emotion, Pert revealed how her study of information-processing receptors on nerve cell membranes led her to discover that the same “neural” receptors were present on most, if not all, of the body’s cells. Her elegant experiments established that the “mind” was not focused in the head but was distributed via signal molecules to the whole body. As importantly, her work emphasized that emotions were not only derived through a feedback of the body’s environmental information. Through self-consciousness, the mind can use the brain to generate “molecules of emotion” and override the system. While proper use of consciousness can bring health to an ailing body, inappropriate unconscious control of emotions can easily make a healthy body diseased,

Consider the genesis of a single-celled embryo produced by the fertilization of an egg by a sperm. The genetic material of this embryo comes from two sources: paternal genes (from sperm) and maternal genes (from eggs). But the cellular material of the embryo comes exclusively from the egg; the sperm is no more than a glorified delivery vehicle for male DNA—a genome equipped with a hyperactive tail. Aside from proteins, ribosomes, nutrients, and membranes, the egg also supplies the embryo with specialized structures called mitochondria. These mitochondria are the energy-producing factories of the cell; they are so anatomically discrete and so specialized in their function that cell biologists call them “organelles”—i.e., mini-organs resident within cells. Mitochondria, recall, carry a small, independent genome that resides within the mitochondrion itself—not in the cell’s nucleus, where the twenty-three pairs of chromosomes (and the 21,000-odd human genes) can be found. The exclusively female origin of all the mitochondria in an embryo has an important consequence. All humans—male or female—must have inherited their mitochondria from their mothers, who inherited their mitochondria from their mothers, and so forth, in an unbroken line of female ancestry stretching indefinitely into the past. (A woman also carries the mitochondrial genomes of all her future descendants in her cells; ironically, if there is such a thing as a “homunculus,” then it is exclusively female in origin—technically, a “femunculus”?) Now imagine an ancient tribe of two hundred women, each of whom bears one child. If the child happens to be a daughter, the woman dutifully passes her mitochondria to the next generation, and, through her daughter’s daughter, to a third generation. But if she has only a son and no daughter, the woman’s mitochondrial lineage wanders into a genetic blind alley and becomes extinct (since sperm do not pass their mitochondria to the embryo, sons cannot pass their mitochondrial genomes to their children). Over the course of the tribe’s evolution, tens of thousands of such mitochondrial lineages will land on lineal dead ends by chance, and be snuffed out. And here is the crux: if the founding population of a species is small enough, and if enough time has passed, the number of surviving maternal lineages will keep shrinking, and shrinking further, until only a few are left. If half of the two hundred women in our tribe have sons, and only sons, then one hundred mitochondrial lineages will dash against the glass pane of male-only heredity and vanish in the next generation. Another half will dead-end into male children in the second generation, and so forth. By the end of several generations, all the descendants of the tribe, male or female, might track their mitochondrial ancestry to just a few women. For modern humans, that number has reached one: each of us can trace our mitochondrial lineage to a single human female who existed in Africa about two hundred thousand years ago. She is the common mother of our species. We do not know what she looked like, although her closest modern-day relatives are women of the San tribe from Botswana or Namibia. I find the idea of such a founding mother endlessly mesmerizing. In human genetics, she is known by a beautiful name—Mitochondrial Eve.

fields and land to one side and the other. It finds its way into wells and is drawn up to launder petticoats and be boiled for tea. It is sucked into root membranes, travels up cell by cell to the surface, is held in the leaves of watercress that find themselves in the soup bowls and on the cheeseboards of the county’s diners. From teapot or soup dish, it passes into mouths, irrigates complex internal biological networks that are worlds in themselves, before returning eventually to the earth via a chamber pot. Elsewhere the river water clings to the leaves of the willows that droop to touch its surface and then, when the sun comes up, a droplet appears to vanish into the air, where it travels invisibly and might join a cloud, a vast floating lake, until it falls again as rain. This is the unmappable journey of the Thames.

Kauffman was in awe when he realized all this. Here it was again: order. Order for free. Order arising naturally from the laws of physics and chemistry. Order emerging spontaneously from molecular chaos and manifesting itself as a system that grows. The idea was indescribably beautiful. But was it life? Well no, Kauffman had to admit, not if you meant life as we know it today. An autocatalytic set would have had no DNA, no genetic code, no cell membrane. In fact, it would have had no real independent existence except as a haze of molecules floating around in some ancient pond. If an extraterrestrial Darwin had happened by at the time, he (or it) would have been hard put to notice anything unusual. Any given molecule participating in the autocatalytic set would have looked pretty much like any other molecule. The essence was not to be found in any individual piece of the set, but in the overall dynamics of the set: its collective behavior.

Einstein said that we only use at most 8% of our brain’s capacity. I know this because one of my favorite things to do each night was to get into bed with her and learn from the books she was reading. She would read out loud to me the facts and then look at me and ask me what I thought. “What do you think is going on with the other 92%?” A cell has a nucleus and some other parts like membranes, plasms and other stuff. Its energy is made up of protons, neurons and electrons. Genetic scientists, however, have discovered that the majority of a cell is made up of something unknown. Something akin to space filled with electromagnetic fibers of light. The human body is made up of some 37 trillion cells. What do you think you are made of? Who do you think you are?

Whatever their size or shape, nearly all your cells are built to fundamentally the same plan: they have an outer casing or membrane, a nucleus wherein resides the necessary genetic information to keep you going, and a busy space between the two called the cytoplasm.

If this is hard to understand from a map, the rest is harder. For one thing, the river that flows ever onwards is also seeping sideways, irrigating the fields and land to one side and the other. It finds its way into wells and is drawn up to launder petticoats and be boiled for tea. It is sucked into root membranes, travels up cell by cell to the surface, is held in the leaves of watercress that find themselves in the soup bowls and on the cheeseboards of the county’s diners. From teapot or soup dish, it passes into mouths, irrigates complex internal biological networks that are worlds in themselves, before returning eventually to the earth via a chamber pot. Elsewhere the river water clings to the leaves of the willows that droop to touch its surface and then, when the sun comes up, a droplet appears to vanish into the air, where it travels invisibly and might join a cloud, a vast floating lake, until it falls again as rain. This is the unmappable journey of the Thames. And there is more: what we see on a map is only the half of it. A river no more begins at its source than a story begins with the first page.

In other words, carbs can be seen as a far dirtier fuel than fats. When you adopt a high-fat, low-carb diet and make the switch to burning fat and ketones for fuel instead of glucose, your mitochondria’s exposure to oxidative damage drops by as much as 30 to 40 percent compared to when your primary source of fuel is sugar, as is typical in American diets today. This means that when you are “fat adapted”—that is, when you have made the transition to burning fat for fuel—your mitochondrial DNA, cell membranes, and protein can remain stronger, healthier, and more resilient. In order

When the same genes are repeatedly activated by the same information from the brain, then the genes keep getting selected over and over again, and just like gears in a car, they start to wear out. The body makes proteins with weaker structures and lesser functions. We get sick and we age. In time, one of two scenarios can occur. The intelligence of the cell membrane, which is consistently receiving the same information, can adapt to the body’s needs and demands by modifying its receptor sites so that it can accommodate more of those chemicals. Basically, it creates more docking stations to satisfy the demand—just as supermarkets open up additional checkout lanes when the lines get too long.

We have phosphate on our DNA. Aluminum attaches itself to it and messes up our genetic coding process. While the aluminum is inside a cell, some of its particles attach to adenosine triphosphate (ATP). The ATP is in charge of our cell’s energy production. So, in this manner the aluminum can affect our energy level. We have enzymes (proteins) within our cells that depend on attaching themselves to calcium (Ca) or magnesium (Mg) to function properly. Once our enzymes have attached to the Ca and Mg, they can carry on with their functions. Because the aluminum has such a strong positive charge, it’s able to break the bond between our enzymes and Ca or Mg. These enzymes are now no longer attached to Ca or Mg. They have become neutralized and are unable to carry out their responsibilities. We need these enzymes for efficient metabolism, but now the aluminum is attached to the enzymes instead. The protein molecules all look a little different because their shape reflects what they are designed to do. Aluminum disturbs their individual tasks and clumps them together so they are now misshapen and no longer functioning. Aluminum also messes with the cell surface, the membrane, the outer layer of the cell. With a dysfunctional cell membrane, everything inside the cell becomes compromised and it is no longer able to properly communicate with the environment surrounding the cell about what needs to be done[96].

Our brains, for instance, are 70 percent fat, mostly in the form of a substance known as myelin that insulates nerve cells and, for that matter, all nerve endings in the body. Fat is the primary component of all cell membranes. Changing the proportion of saturated to unsaturated fats in the diet, as proponents of Keys’s hypothesis recommended, might well change the composition of the fats in the cell membranes. This could alter the permeability of cell membranes, which determines how easily they transport, among other things, blood sugar, proteins, hormones, bacteria, viruses, and tumor-causing agents into and out of the cell. The relative saturation of these membrane fats could affect the aging of cells and the likelihood that blood cells will clot in vessels and cause heart attacks.

professor taps his laptop, the images change, and we are lost in the world of red blood cells. The cell’s nucleus is small and round and serves as the cell’s command center. It controls the cell’s growth and reproduction. It is surrounded by a membrane. And on and on. Attached to our petition was Benderschmidt’s full report, including pages of impenetrable stuff on cells and blood. I confess that I have not read it entirely, but something tells me Judge Kumar has.

Order Out of Chaos ... At the right temperature ... two peptide molecules will stay together long enough on average to find a third. Then the little trio finds a fourth peptide to attract into the little huddle, just through the random side-stepping and tumbling induced by all the rolling water molecules. Something extraordinary is happening: a larger structure is emerging from a finer system, not in spite of the chaotic and random motion of that system but because of it. Without the chaotic exploration of possibilities, the rare peptide molecules would never find each other, would never investigate all possible ways of aggregating so that the tape-like polymers emerge as the most likely assemblies. It is because of the random motion of all the fine degrees of freedom that the emergent, larger structures can assume the form they do. Even more is true when the number of molecules present becomes truly enormous, as is automatically the case for any amount of matter big enough to see. Out of the disorder emerges a ... pattern of emergent structure from a substrate of chaos.... The exact pressure of a gas, the emergence of fibrillar structures, the height in the atmosphere at which clouds condense, the temperature at which ice forms, even the formation of the delicate membranes surrounding every living cell in the realm of biology -- all this beauty and order becomes both possible and predictable because of the chaotic world underneath them.... Even the structures and phenomena that we find most beautiful of all, those that make life itself possible, grow up from roots in a chaotic underworld. Were the chaos to cease, they would wither and collapse, frozen rigid and lifeless at the temperatures of intergalactic space. This creative tension between the chaotic and the ordered lies within the foundations of science today, but it is a narrative theme of human culture that is as old as any. We saw it depicted in the ancient biblical creation narratives of the last chapter, building through the wisdom, poetic and prophetic literature. It is now time to return to those foundational narratives as they attain their climax in a text shot through with the storm, the flood and the earthquake, and our terrifying ignorance in the face of a cosmos apparently out of control. It is one of the greatest nature writings of the ancient world: the book of Job.

These proteins come in many types. Fibrous proteins, for example, form structures such as bones, tissues, muscles, hair, fingernails, tendons, and skin cells. Membrane proteins relay signals within cells. Above all is the most fascinating type of proteins: enzymes. They serve as catalysts. They spark and accelerate and modulate the chemical reactions in all living things. Almost every action that takes place in a cell needs to be catalyzed by an enzyme. Pay attention to enzymes

The distribution of salt throughout food can be explained by osmosis and diffusion, two chemical processes powered by nature’s tendency to seek equilibrium, or the balanced concentration of solutes such as minerals and sugars on either side of a semipermeable membrane (or holey cell wall). In food, the movement of water across a cell wall from the saltier side to the less salty side is called osmosis. Diffusion, on the other hand, is the often slower process of salt moving from a

- Vous croyez que mes crimes rendent vos mauvaises actions moins condamnables ? Vos petitesses et vos vices moins hideux ? Vous croyez qu'il y a les meurtriers, les violeurs, les criminels d'un côté et vous de l'autre ? C'est cela qu'il vous faut comprendre : il n'y a pas une membrane étanche qui empêcherait le mal de circuler. Il n'y a pas deux sortes d'humanité. Quand vous mentez à votre femme et à vos enfants, quand vous abandonnez votre vieille mère dans une maison de retraite pour être plus libre de vos mouvements, quand vous vous enrichissez sur le dos des autres, quand vous rechignez à verser une partie de votre salaire à ceux qui n'ont rien, quand vous faites souffrir par égoïsme ou par indifférence, vous vous rapprochez de ce que je suis. Au fond, vous êtes beaucoup plus proches de moi et des autres pensionnaires que vous ne le croyez. C'est une question de degré, pas une question de nature. Notre nature est commune : c'est celle de l'humanité toute entière.

It's this human porosity that bothers me and that I can't escape since it is the faith of my skin, the extra sense which is everywhere in my being, this lack of eyelids on the face of the soul, or perhaps this imaginary lack of imaginary lids, this excessive facility I have for catching others, I am caught by persons or things animated or unanimated that I don't even frequent, and even the verb catch I catch or rather I am caught by it, for, note this please, it's not I who wish to change, it's the other who gets his hooks in me for lack of armor. All it takes is for me to be plunged for an hour or less into surroundings where the inevitable occurs--cafe, bus, hair salon, train carriage, recording studio--there must be confinement and envelopment, and there I am stained intoxicated, practically any speaker can appropriate my mental cells and poison my sinuses, shit, idiocies, cruelties, vulgar spite, trash, innumerable particles of human hostility inflame the windows of my brain and I get off the transport sick for days. It isn't the fault of one Eichmann or another. I admit to being guilty of excessive receptivity to mental miasma. The rumor of a word poisons me for a long time. Should I read or hear such and such a turn of phrase or figure of speech, right away I can't breathe my mucous membranes swell up, my lips go dry, I am asthmaticked, sometimes I lose my balance and crash to the ground, or on a chair if perchance one is there, in the incapacity of breathing the unbreathable.

We have established on thermodynamic grounds that to make a cell from scratch requires a continuous flow of reactive carbon and chemical energy across rudimentary catalysts in a constrained through-flow system. Only hydrothermal vents provide the requisite conditions, and only a subset of vents – alkaline hydrothermal vents – match all the conditions needed. But alkaline vents come with both a serious problem and a beautiful answer to the problem. The serious problem is that these vents are rich in hydrogen gas, but hydrogen will not react with CO2 to form organics. The beautiful answer is that the physical structure of alkaline vents – natural proton gradients across thin semiconducting walls – will (theoretically) drive the formation of organics. And then concentrate them. To my mind, at least, all this makes a great deal of sense. Add to this the fact that all life on earth uses (still uses!) proton gradients across membranes to drive both carbon and energy metabolism, and I’m tempted to cry, with the physicist John Archibald Wheeler, ‘Oh, how could it have been otherwise! How could we all have been so blind for so long!’ Let

My laboratory is interested in the related challenges of understanding the origin of life on the early earth, and constructing synthetic cellular life in the laboratory. Focusing on artificial life frees us to explore novel chemical systems, but what we learn from these systems helps us to understand possible pathways leading to the origin of life. Our basic design for a synthetic cell involves the encapsulation of a spontaneously replicating nucleic acid, which acts as the genetic material, within a spontaneously replicating membrane vesicle, which provides spatial localization. We are using chemical synthesis to make nucleic acids with modified nucleobases and sugar-phosphate backbones.

The watcher’s eyes are likely to swivel forward in a sequence of stately turns as the screen’s pixel glows: each quarter-ounce mass of eyeball tugged by six flat muscles, in a glissando slide within the slippery fat lining the orbital cavity. The eye blinks, the widened pupils are in position, and the incoming electromagnetic waves roar in. Ripping through the thin layer of the cornea, they decelerate slightly, with their outermost edges forming a nearly flat plane as they travel inward, carrying the as-yet-undetected signal from the screen deep into the waiting human. The waves continue through the liquid of the aqueous humor and on to the gaping hole of the pupil. The human may have squinted to avoid the glare, but human reflexes work at the rate of slow thousandths of a second and are no match for these racing intruders. The pupil is crossed without obstruction. The stiff lens just below focuses the incoming waves even more, sending them into the inland sea of the jellylike vitreous humor deeper down in the eye. A very few of the incoming electric waves explode against the organic molecules in their way, but most simply whirl through those soft biological barriers and continue straight down, piercing the innermost wrapping of the eyeball, till they reach the end-point of their journey: the fragile, stalklike projection from the living brain known as the retina. And deep inside there, in the dark, barely slowed from their original 670 million mph, the waves splatter into the ancient, moist blood vessels and cell membranes, and something unexpected happens. An electric current switches on.

Milk thistle (Silybum marianum) has been studied in the treatment of liver disease. The active component, silymarin, is found in the entire plant but is concentrated in the fruit and seeds. Silymarin is a potent antioxidant and acts as a toxin blockade by inhibiting toxins from binding to membrane receptors on the surface of liver cells (called hepatocytes). Silymarin can protect the liver from being injured by, for example, different toxins, radiation, and iron overload. It has been successfully used to treat alcoholic liver disease, acute and chronic viral hepatitis, and toxin-induced liver diseases. (There are also some studies showing no effect of silymarin and many studies showing that vitamin C is just as good.) While seeds are generally avoided on the Paleo Approach, milk thistle seed extract may be a beneficial supplement (unless the very small amount of alcohol in the supplement is not tolerated; see here). Milk thistle tea is also a good option.

And there is more still. DNA, proteins, and the other components of life couldn’t prosper without some sort of membrane to contain them. No atom or molecule has ever achieved life independently. Pluck any atom from your body, and it is no more alive than is a grain of sand. It is only when they come together within the nurturing refuge of a cell that these diverse materials can take part in the amazing dance that we call life. Without the cell, they are nothing more than interesting chemicals. But without the chemicals, the cell has no purpose. As the physicist Paul Davies puts it, “If everything needs everything else, how did the community of molecules ever arise in the first place?” It is rather as if all the ingredients in your kitchen somehow got together and baked themselves into a cake—but a cake that could moreover divide when necessary to produce more cakes. It is little wonder that we call it the miracle of life. It is also little wonder that we have barely begun to understand it.

It is hard to feel affection for something as totally impersonal as the atmosphere, and yet there it is, as much a part and product of life as wine and bread. Taken all in al, the sky is a miraculous achievement. It works, and for what it is designed to accomplish it is as infallible as anything in nature. I doubt whether any of us could think of a way to improve on it, beyond maybe shifting a local cloud from here to there on occasion. The word 'chance' does not serve to account well for structures of such magnificence... We should credit it for what it is: for sheer size and perfection of function, it is far and away the grandest product of collaboration in all of nature. It breathes for us, and it does another thing for our pleasure. Each day, millions of meteorites fall against the outer limits of the membrane and are burned to nothing by the friction. Without this shelter, our surface would long since have become the pounded powder of the moon. Even though our receptors are not sensitive enough to hear it, there is comfort in knowing the sound is there overhead, like the random noise of rain on the roof at night.

Indeed, as predicted, when the gene encoding the hemoglobin B chain was later identified and sequenced in sickle-cell patients, there was a single change: one triplet in DNA-GAG-had changed to another-GTG. This resulted in the substitution of one amino acid for another: glutamate was switched to valine. That switch altered the folding of the hemoglobin chain: rather than twisting into its neatly articulated, clasplike structure, the mutant hemoglobin protein accumulated in stringlike clumps within red cells. These clumps grew so large, particularly in the absence of oxygen, that they tugged the membrane of the red cell util the normal disk was warped into a crescent-shaped dysmorphic "sickle cell." Unable to glide smoothly through capillaries and veins, sickled red cells jammed into microscopic clots throughout the body, interrupting blood flow and precipitating the excruciating pain of a sickling crisis. It was a Rube Goldberg disease. A change in the sequence of a gene caused the change in the sequence of a protein; that warped its shape; that shrank a cell; that clogged a vein; that jammed the flow; that racked the body (that genes built). Gene, protein, function, and fate were strung in a chain: one chemical alteration in one base pair in DNA was sufficient to "encode" a radical change in human fate.

Say the planet is born at midnight and it runs for one day. First there is nothing. Two hours are lost to lava and meteors. Life doesn’t show up until three or four a.m. Even then, it’s just the barest self-copying bits and pieces. From dawn to late morning—a million million years of branching—nothing more exists than lean and simple cells. Then there is everything. Something wild happens, not long after noon. One kind of simple cell enslaves a couple of others. Nuclei get membranes. Cells evolve organelles. What was once a solo campsite grows into a town. The day is two-thirds done when animals and plants part ways. And still life is only single cells. Dusk falls before compound life takes hold. Every large living thing is a latecomer, showing up after dark. Nine p.m. brings jellyfish and worms. Later that hour comes the breakout—backbones, cartilage, an explosion of body forms. From one instant to the next, countless new stems and twigs in the spreading crown burst open and run. Plants make it up on land just before ten. Then insects, who instantly take to the air. Moments later, tetrapods crawl up from the tidal muck, carrying around on their skin and in their guts whole worlds of earlier creatures. By eleven, dinosaurs have shot their bolt, leaving the mammals and birds in charge for an hour. Somewhere in that last sixty minutes, high up in the phylogenetic canopy, life grows aware. Creatures start to speculate. Animals

REPROGRAMMING MY BIOCHEMISTRY A common attitude is that taking substances other than food, such as supplements and medications, should be a last resort, something one takes only to address overt problems. Terry and I believe strongly that this is a bad strategy, particularly as one approaches middle age and beyond. Our philosophy is to embrace the unique opportunity we have at this time and place to expand our longevity and human potential. In keeping with this health philosophy, I am very active in reprogramming my biochemistry. Overall, I am quite satisfied with the dozens of blood levels I routinely test. My biochemical profile has steadily improved during the years that I have done this. For boosting antioxidant levels and for general health, I take a comprehensive vitamin-and-mineral combination, alpha lipoic acid, coenzyme Q10, grapeseed extract, resveratrol, bilberry extract, lycopene, silymarin (milk thistle), conjugated linoleic acid, lecithin, evening primrose oil (omega-6 essential fatty acids), n-acetyl-cysteine, ginger, garlic, l-carnitine, pyridoxal-5-phosphate, and echinacea. I also take Chinese herbs prescribed by Dr. Glenn Rothfeld. For reducing insulin resistance and overcoming my type 2 diabetes, I take chromium, metformin (a powerful anti-aging medication that decreases insulin resistance and which we recommend everyone over 50 consider taking), and gymnema sylvestra. To improve LDL and HDL cholesterol levels, I take policosanol, gugulipid, plant sterols, niacin, oat bran, grapefruit powder, psyllium, lecithin, and Lipitor. To improve blood vessel health, I take arginine, trimethylglycine, and choline. To decrease blood viscosity, I take a daily baby aspirin and lumbrokinase, a natural anti-fibrinolytic agent. Although my CRP (the screening test for inflammation in the body) is very low, I reduce inflammation by taking EPA/DHA (omega-3 essential fatty acids) and curcumin. I have dramatically reduced my homocysteine level by taking folic acid, B6, and trimethylglycine (TMG), and intrinsic factor to improve methylation. I have a B12 shot once a week and take a daily B12 sublingual. Several of my intravenous therapies improve my body’s detoxification: weekly EDTA (for chelating heavy metals, a major source of aging) and monthly DMPS (to chelate mercury). I also take n-acetyl-l-carnitine orally. I take weekly intravenous vitamins and alpha lipoic acid to boost antioxidants. I do a weekly glutathione IV to boost liver health. Perhaps the most important intravenous therapy I do is a weekly phosphatidylcholine (PtC) IV, which rejuvenates all of the body’s tissues by restoring youthful cell membranes. I also take PtC orally each day, and I supplement my hormone levels with DHEA and testosterone. I take I-3-C (indole-3-carbinol), chrysin, nettle, ginger, and herbs to reduce conversion of testosterone into estrogen. I take a saw palmetto complex for prostate health. For stress management, I take l-theonine (the calming substance in green tea), beta sitosterol, phosphatidylserine, and green tea supplements, in addition to drinking 8 to 10 cups of green tea itself. At bedtime, to aid with sleep, I take GABA (a gentle, calming neuro-transmitter) and sublingual melatonin. For brain health, I take acetyl-l-carnitine, vinpocetine, phosphatidylserine, ginkgo biloba, glycerylphosphorylcholine, nextrutine, and quercetin. For eye health, I take lutein and bilberry extract. For skin health, I use an antioxidant skin cream on my face, neck, and hands each day. For digestive health, I take betaine HCL, pepsin, gentian root, peppermint, acidophilus bifodobacter, fructooligosaccharides, fish proteins, l-glutamine, and n-acetyl-d-glucosamine. To inhibit the creation of advanced glycosylated end products (AGEs), a key aging process, I take n-acetyl-carnitine, carnosine, alpha lipoic acid, and quercetin. MAINTAINING A POSITIVE “HEALTH SLOPE” Most important,

Suppose you entered a boat race. One hundred rowers, each in a separate rowboat, set out on a ten-mile race along a wide and slow-moving river. The first to cross the finish line will win $10,000. Halfway into the race, you’re in the lead. But then, from out of nowhere, you’re passed by a boat with two rowers, each pulling just one oar. No fair! Two rowers joined together into one boat! And then, stranger still, you watch as that rowboat is overtaken by a train of three such rowboats, all tied together to form a single long boat. The rowers are identical septuplets. Six of them row in perfect synchrony while the seventh is the coxswain, steering the boat and calling out the beat for the rowers. But those cheaters are deprived of victory just before they cross the finish line, for they in turn are passed by an enterprising group of twenty-four sisters who rented a motorboat. It turns out that there are no rules in this race about what kinds of vehicles are allowed. That was a metaphorical history of life on Earth. For the first billion years or so of life, the only organisms were prokaryotic cells (such as bacteria). Each was a solo operation, competing with others and reproducing copies of itself. But then, around 2 billion years ago, two bacteria somehow joined together inside a single membrane, which explains why mitochondria have their own DNA, unrelated to the DNA in the nucleus.35 These are the two-person rowboats in my example. Cells that had internal organelles could reap the benefits of cooperation and the division of labor (see Adam Smith). There was no longer any competition between these organelles, for they could reproduce only when the entire cell reproduced, so it was “one for all, all for one.” Life on Earth underwent what biologists call a “major transition.”36 Natural selection went on as it always had, but now there was a radically new kind of creature to be selected. There was a new kind of vehicle by which selfish genes could replicate themselves. Single-celled eukaryotes were wildly successful and spread throughout the oceans.

A virus particle is a very small capsule made of proteins locked together in a mathematical pattern. The pattern of the interlocking proteins in a virus is far more complicated than a snowflake. The protein capsule is sometimes wrapped in an oily membrane. Inside the capsule there is a small amount of DNA or RNA, the molecules that contain the genetic code of the virus. The genetic code is the virus’s operating system, or wetware, the complete set of instructions for the virus to make copies of itself. Unlike a snowflake or any other kind of crystal, a virus is able to re-create its form. It would be as if a single snowflake started copying itself as it falls, and those copies of the snowflake copy themselves, creating ever-growing numbers of identical copies of the first snowflake, until the air is filled with falling snow, and each flake is a perfect replica of the first flake. Many virologists feel that viruses are not truly living things. At the same time, viruses are obviously not dead. Virologists like to describe them as life forms. The term is a contradiction: How can something be a form of life that isn’t alive? Viruses carry on their existence in a misty borderland that lies between life and death, a gray zone where the things we encounter are neither provably alive nor certainly dead. One way to understand viruses is to think about them as biological machines. A virus is a wet nanomachine, a tiny, complicated, slightly fuzzy mechanism, which is rubbery, flexible, wobbly, and often a little bit imprecise in its operation—a microscopic nugget of squishy parts. Viruses are subtle, logical, tricky, reactive, devious, opportunistic. They are constantly evolving, their forms steadily changing as time passes. Like all kinds of life, viruses possess a relentless drive to reproduce themselves so that they can persist through time. When a virus starts copying itself strongly and rapidly in a host, the process is called virus amplification. As a virus amplifies itself in its host, the host, a living organism, can be destroyed. Viruses are the undead of the living world, the zombies of deep time. Nobody knows the origin of viruses—how they came into existence or when they appeared in the history of life on earth. Viruses may be examples or relics of life forms that operated at the dawn of life. Viruses may have come into existence with the first stirrings of life on the planet, roughly four billion years ago. Or they may have arisen after life started, during the time when single-celled bacteria had already come into existence—nobody knows.

Now when a muscle cell is stimulated by its motor nerve—and only when it is stimulated by its nerve—the electrical charge from the membrane of the nerve cell is transmitted to the membrane of the muscle cell; from the membrane of the muscle cell, this charge is picked up by the transverse tubules which in turn transmit it to the interior of the muscle cell, where it contacts the membranes of the sarcoplasmic reticulum. When the reticulum is touched by the charge, pores in its delicate membrane open up, allowing the positive calcium ions to rush out into the cellular fluid, where they bond to the actin chains, initiating the cross-bridging cycles.

At their invitation we crowded into the spacious control cabin of the great airship, where scientific gear occupied every available cubic—perhaps hypercubic—inch. Among the fantastical glass envelopes and knottings of gold wire as unreadable to us as the ebonite control panels scrupulously polished and reflecting the Arctic sky, we were able here and there to recognize more mundane items—here Manganin resistance-boxes and Tesla coils, there Leclanché cells and solenoidal magnets, with electrical cables sheathed in commercial-grade Gutta Percha running everywhere. Inside, the overhead was much higher than expected, and the bulkheads could scarcely be made out in the muted light through three hanging Fresnel lenses, the mantle behind each glowing a different primary color, from sensitive-flames which hissed at different frequencies. Strange sounds, complex harmonies and dissonances, resonant, sibilant, and percussive at once, being monitored from someplace far Exterior to this, issued from a large brass speaking-trumpet, with brass tubing and valvework elaborate as any to be found in an American marching band running back from it and into an extensive control panel on which various metering gauges were ranked, their pointers, with exquisite Breguet-style arrowheads, trembling in their rise and fall along the arcs of italic numerals. The glow of electrical coils seeped beyond the glass cylinders which enclosed them, and anyone’s hands that came near seemed dipped in blue chalk-dust. A Poulsen’s Telegraphone, recording the data being received, moved constantly to and fro along a length of shining steel wire which periodically was removed and replaced. “Ætheric impulses,” Dr. Counterfly was explaining. “For vortex stabilization we need a membrane sensitive enough to respond to the slightest eddies. We use a human caul—a ‘veil,’ as some say.” “Isn’t a child born with a veil believed to have powers of second sight?” Dr. Vormance inquired. “Correct. And a ship with a veil aboard it will never sink—or, in our case, crash.” “Things have been done to obtain a veil,” darkly added a junior officer, Mr. Suckling, “that may not even be talked about.

The contractile portions of the intrafusal fibers are innervated by motor neurons in the same fashion as are the larger skeletal muscle cells. The intrafusal membrane is contacted by a motor end plate, which stimulates the spindle cell into contracting or fixing its length, or ceases stimulation to allow the cell to be lengthened passively. But the motor neurons which control the intrafusals are altogether separate from the ones which control the skeletal muscles. The skeletal motor neurons are larger in diameter, with their own vertical tracts through the length of the spinal cord, and end their paths near the summit of the brain, in the motor cortex. They are called alpha motor neurons. The motor neurons for the intrafusal fibers, in contrast, are smaller in diameter, have their own discrete pathways up the spinal cord, and end in collections of cell bodies, or ganglia, deep within the brain, in the brain stem. These are called the gamma neurons.

provides protection for cell membranes and an ideal level for cognitive functioning is 12-20mcg/ml.

Normally, when sugar enters the bloodstream from our gut, the pancreas secretes insulin into the bloodstream, and the insulin then travels to three main places: fat cells, muscle cells, and neurons. Insulin’s primary job is to open the door to any cell to allow glucose to enter and provide fuel, particularly to three important types of cells. 1. IN FAT CELLS, insulin attaches to a docking port on a fat cell membrane and flips a switch that tells the fat cell to convert that glucose to fat and store it. When insulin has done its job, it separates from the docking port and no more sugar can enter the cell. 2. IN MUSCLE CELLS, insulin unlocks the door to the cell and ushers in glucose to be used as fuel. 3. NERVE CELLS (neurons) also require insulin to admit glucose through their cell membrane. The fact that neurons require insulin to get glucose is a relatively new finding, and we now know that insulin resistance also occurs in the brain and nerves—it is called type 3 diabetes. Once insulin docks in the appropriate ports and releases information, the fat, muscle, or nerve cells tell the hormone that the message has been received. The hormone then backs out of the docking port, leaving it ready and available for the next hormone to attach.

As we’ve seen, science is only recently discovering that both fat and cholesterol are severely deficient in diseased brains and that high total cholesterol levels in late life are associated with increased longevity.24 The brain holds only 2 percent of the body’s mass but contains 25 percent of the total cholesterol, which supports brain function and development. One-fifth of the brain by weight is cholesterol! Cholesterol forms membranes surrounding cells, keeps cell membranes permeable, and maintains cellular “waterproofing” so different chemical reactions can take place inside and outside the cell. We’ve actually determined that the ability to grow new synapses in the brain depends on the availability of cholesterol, which latches cell membranes together so that signals can easily jump across the synapse. It’s also a crucial component in the myelin coating around the neuron, allowing quick transmission of information. A neuron that can’t transmit messages is useless, and it only makes sense to cast it aside like junk—the debris of which is the hallmark of brain disease. In essence, cholesterol acts as a facilitator for the brain to communicate and function properly.

What would we learn from an alien? It could be astonishing. We’d quickly find out if life necessarily needs a genetic code, a cell membrane, similar kinds of appendages, and familiar sorts of sensory organs.

We owe our liberation to chemistry," he went on. "For all perception is but a change in the concentration of hydrogen ions on the surface of the brain cells. Seeing me, you actually experience a disturbance in the sodium-potassium equilibrium across your neuron membranes. So all we have to do is send a few well-chosen molecules down into those cortical mitochondria, activate the right neurohumoral-synaptic transmission effector sites, and your fondest dreams come true. But you know all this," he concluded, subdued.

While the mechanisms involved in electrochemical signaling are complex, the basic principles are simple. Just as a battery maintains its charge by housing different electrolytes in different compartments, a cell has a charge owing to different amounts of various salts in and outside the cell. There is more sodium on the outside of cells and more potassium inside. (That's why salt balances are so important in our diets.) When a mechanoreceptor is activated, let's say by your thumb touching the spacebar on a keyboard, specific channels open up near the point of contact in the cell membrane that allow sodium to pass into the cell. This movement of sodium changes the electric charge, which leads to the opening of additional channels and increased sodium flux. This results in the depolarization that propagates along the length of the neuron like a wave propagating across the ocean.

Yes. There are a variety of reasons that we as humans age, one of which is oxidant stress from free radical formation. Known as the Free Radical Theory of Aging, this explanation was first proposed by Denham Harman in the 1950s. Other theories include unchecked inflammation, glycation, cell membrane and DNA damage. Interestingly, they are interrelated as I will explain. Every cell in our body requires energy for a variety of processes. The production of such cellular energy or ATP (adenosine triphosphate) is occurring at the molecular level, unbeknownst to you, billions of times per second, in cellular structures known as mitochondria. Through a complex series of chemical reactions, electrons are ultimately transferred to oxygen, driving the formation of ATP molecules. No oxygen, no electron receptor, death ensues. (Note: Cyanide poisons this so-called “electron transport chain” often times resulting in death.) This process of ATP generation is imperfect.

A cell’s membrane, which constitutes its outer surface, is composed of lipid molecules.

Collectively, these three cellular elements—nucleic acids, proteins, and the lipid bilayer membrane—exist for the purpose of maintaining the cell as a living system, but for this it needs a fourth class of materials, sugars (saccharides, typically glucose or sucrose).

So how does a cell go about ending its own existence? The actual mechanism of ‘cell suicide’ depends upon mitochondria, termed the ‘angels of death’ by Nick Lane in his book, Power, Sex and Suicide: Mitochondria and the Meaning of Life . The first change occurs in the mitochondrial inner membrane, which becomes damaged by aberrant biochemical activity, leading to the formation of pores in the mitochondrial membrane (Figure 12b, d). At this point, the mitochondrion becomes committed to trigger apoptosis, and releases cytochrome c (a protein crucial to its normal function of energy production) which exits through the newly formed pores. This information came to light as a result of some neat experiments in which apoptotic mitochondria were introduced into perfectly healthy cells, resulting in apoptosis. The released cytochrome c binds to several other proteins in the cytoplasm to form a complex called the apoptosome which, in turn, activates a cascade of ‘executioner enzymes’ which not only kill the cell but cause fragmentation of the nucleus and cytoplasm into bite-size pieces ready to be phagocytosed by neighbouring cells.

Say the planet is born at midnight and it runs for one day. First there is nothing. Two hours are lost to lava and meteors. Life doesn’t show up until three or four a.m. Even then, it’s just the barest self-copying bits and pieces. From dawn to late morning—a million million years of branching—nothing more exists than lean and simple cells. Then there is everything. Something wild happens, not long after noon. One kind of simple cell enslaves a couple of others. Nuclei get membranes. Cells evolve organelles. What was once a solo campsite grows into a town. The day is two-thirds done when animals and plants part ways. And still life is only single cells. Dusk falls before compound life takes hold. Every large living thing is a latecomer, showing up after dark.

The cell membrane undergoes a change that allows it to shrink and collapse without sustaining irreparable damage. Most importantly, the enzymes of cell repair are synthesized and stored for future access.

A change of lifestyle becomes vital for the correction of any dehydration-produced disorder. The backbone of The Water Cure program is, simply, sufficient water and salt intake; regular exercise; a balanced, mineral-rich diet that includes lots of fruits and vegetables and the essential fats needed to create cell membranes, hormones, and nerve insulation; exclusion of caffeine and alcohol; and meditation to solve and detoxify stressful thoughts. Exclusion of artificial sweeteners from the diet is an absolute must for better health.

The scientific basis for separating neocortical from limbic brain matter rests on solid neuroanatomical, cellular, and empirical grounds. As viewed through the microscope, limbic areas exhibit a far more primitive cellular organization than their neocortical counterparts. Certain radiographic dyes selectively stain limbic structures, thus painting the molecular dissimilarity between the two brains in clean, vivid strokes. One researcher made an antibody that binds to cells of the hippocampus—a limbic component—and found that those same fluorescent markers stuck to all parts of the limbic brain, lighting it up like a biological Christmas tree, without coloring the neocortex at all. Large doses of some medications destroy limbic tissue while leaving the neocortex unscathed, a sharp-shooting feat enabled by evolutionary divergence in the chemical composition of limbic and neocortical cell membranes.

Horseradish Schnapps You need fresh horseradish root for this liquor. Jarred prepared horseradish is too finely grated, which tends to make the spirit overly cloudy. It also contains trace amounts of vinegar, oil, and salt, which would affect the clean, clear flavor. Whole horseradish root has practically no aroma, but when it is grated, the broken cells produce mustard oil (horseradish and mustard belong to the same botanical family), which irritates your mucous membranes. The membranes weep to rid your system of the irritating oil, producing a cleansing effect throughout your skull. That effect, though moderately painful, is wonderfully refreshing. Makes 1 pint Ingredients 1 fifth (750 ml/31⁄4 cups) vodka (80–100 proof) 11⁄2 cups coarsely shredded fresh horseradish root Instructions Combine the vodka and horseradish in a half-gallon jar. Stir to moisten the horseradish. Seal the jar and put it in a cool, dark cabinet until the liquid smells and tastes strongly of horseradish, 2 to 4 hours. Strain the mixture with a mesh strainer lined with several layers of dampened cheesecloth into a clean quart jar. Do not push on the solids to extract more liquid. Seal and store in a cool, dark cabinet. Use within 1 year. Note: The liqueur will precipitate small bits of horseradish as it sits. These are not harmful, but you might find them unattractive. To cleanse your Horseradish Schnapps, follow the directions for clarifying (see page 8).

Commercial polyunsaturated oils, such as soy oil, safflower oil, corn oil, cottonseed oil and canola oil, create serious imbalances on the cellular level. They are invariably rancid and a source of cancer-causing free radicals. Furthermore, they are loaded with hormone-like chemicals. The scientific literature indicates that overconsumption of polyunsaturated oils is especially damaging to the reproductive organs like the breasts. Even worse, most of the vegetables oils in our food come in the form of partially hydrogenated vegetable oils. When these altered fats are built into the cell membranes, they inhibit thousands of chemical reactions on the cellular level. Several major studies have definitely correlated consumption of partially hydrogenated vegetable oils with increased breast cancer but this fact is rarely mentioned, even in books that espouse alternative treatments to breast cancer.

It’s the polyunsaturated fats and oils, derived from seeds such as sunflower, safflower, soy, and corn, that are the major dietary sources of linoleic acid; they are the most harmful oils for those with intestinal problems because they increase inflammation. When it is absorbed in the intestinal lining, linoleic acid is transformed to arachidonic acid, which is a component of the cell membranes in the bowel. Arachidonic acid can then be converted into various inflammatory chemicals.

Our brains, for instance, are 70 percent fat, mostly in the form of a substance known as myelin that insulates nerve cells and, for that matter, all nerve endings in the body. Fat is the primary component of all cell membranes. Changing the proportion of saturated to unsaturated fats in the diet, as proponents of Keys’s hypothesis recommended, might well change the composition of the fats in the cell membranes. This could alter the permeability of cell membranes, which determines how easily they transport, among other things, blood sugar, proteins, hormones, bacteria, viruses, and tumor-causing agents into and out of the cell.” Gary Taubes, Good Calories, Bad Calories (New York: Anchor, 2008), p. 30–31.

There are still other types of fats found in grass-fed butter that has health benefits. Some of them are used in building cell membranes, which is necessary in repair and replacement

We should credit [the sky] for what it is: for sheer size and perfection of function, it is far and away the grandest product of collaboration in all of nature. It breathes for us, and it does another thing for our pleasure. Each day, millions of meteorites fall against the outer limits of the membrane and are burned to nothing by the friction. Without this shelter, our surface would long since have become the pounded powder of the moon. Even though our receptors are not sensitive enough to hear it, there is comfort in knowing that the sound is there overhead, like the random noise of rain on the roof at night.

fatty acids are not just stored as fat; they are also used as building blocks in every cell membrane. And those membranes are not simply containers, like ziplock bags. Instead, they are more like patrol sentries on a highly trafficked border, carefully regulating everything going in and out of the cell. They also control what hangs out right on the border, inside the membrane. Kummerow found that when trans-fatty acids occupy cell-membrane positions, they are like foreign agents who do not operate according to the normal plan.

The solution may be to return to stable, solid animal fats, like lard and butter, which don’t contain any mystery isomers or clog up cell membranes, as trans fats do, and don’t oxidize, as do liquid oils. Saturated fats, which also raise HDL-cholesterol, start to look like a rather good alternative from this perspective.

Hormones modify this flow of fatty acids back and forth across the membranes of the fat cells, and they modify the expenditure of energy by the tissues and organs. Hormones, and particularly insulin—“even in trace amounts,” as Ernst Wertheimer explained—“have powerful direct effect on adipose tissue.

Cholesterol is a little waxy lipid (fat) molecule that happens to be one of the most important substances in the human body. Every cell membrane has cholesterol as a critical structural and functional component. Brain cells need cholesterol to make synapses (connections) with other brain cells. Cholesterol is the precursor molecule for important hormones such as testosterone, estrogen, DHEA, cortisol, and pregnenolone. Cholesterol is needed for making the bile acids that allow us to digest and absorb fats. Cholesterol interacts with sunlight to convert into the all-important vitamin D. Bottom line is that you can’t live without cholesterol,

The major mechanisms by which cells transmit signals to each other, and how these signals are conveyed from the cell membrane to the nucleus to modulate gene expression, commonly referred to as cell signalling, are also covered in Chapter 2.

Experimental evidence suggests that a key element underlying a daughter cell's becoming an outer cell is inheritance of a patch of outer cell membrane containing microvilli and the actin microfilament-stabilizing protein, ezrin. The proteins that produce polarity in the outer cells are postulated to direct their differentiation toward the trophoblastic lineage. Common to the inside-outside hypothesis and the cell polarity model is the recognition that a cell that does not contact the surface does not differentiate into trophoblast, but rather becomes part of the inner cell mass.

From the start, one of the main factors in the discussion of heart disease has been cholesterol, the yellow, waxy substance that is a necessary part of all body tissues. It is a vital component of every cell membrane, controlling what goes in and out of the cell.

all life forms, no matter how diverse, have common characteristics: 1) they are made up of cells, enclosed by a membrane that maintains internal conditions different from their surroundings, 2) they contain DNA or RNA as the material that carries their master plan, and 3) they carry out a process, called metabolism, which involves the conversion of different forms of energy by means of which they sustain themselves.

Cholesterol performs many vital functions, but we’ll focus on three specifically: cell membrane structure and support, hormone synthesis, and vitamin D production.

I raise my grease gun and I aim it at Cowboy's face. Cowboy looks pitiful and he's terrified. Cowboy is paralyzed by the shock that is setting in and by the helplessness. I hardly know him. I remember the first time I saw Cowboy, on Parris Island, laughing, beating his Stetson on his thigh. I look at him. He looks at the grease gun. He calls out: "I NEVER LIKED YOU, JOKER. I NEVER THOUGHT YOU WERE FUNNY--" Bang. I sight down the short metal tube and I watch my bullet enter Cowboy's left eye. My bullet passes through his eye socket, punches through fluid-filled sinus cavities, through membranes, nerves, arteries, muscle tissue, through the tiny blood vessels that feed three pounds of gray butter-soft high protein meat where brain cells arranged like jewels in a clock hold every thought and memory and dream of one adult maleHomo sapiens. My bullet exits through the occipital bone, knocks out hairy, brain-wet clods of jagged meat, then buries itself in the roots of a tree. Silence. Animal Mother lowers his M-60. Animal Mother, Donlon, Lance Corporal Stutten, Harris, and the other guys in the squad do not speak. Everyone relaxes, glad to be alive. Everyone hates my guts, but they know I'm right. I am their sergeant; they are my men. Cowboy was killed by sniper fire, they'll say, but they'll never see me again; I'll be invisible.

Many experts believe there is a direct connection between consuming processed foods and obesity (beyond their direct contribution to caloric excess), theorizing that insulin resistance could be exacerbated by dysfunctional fat molecules accumulating in cell membranes.

Ivermectin was found as a blocker of viral replicase, protease and human TMPRSS2, which could be the biophysical basis behind its antiviral efficiency.” The drug also reduces inflammation via multiple pathways, thereby protecting against organ damage. Ivermectin furthermore impairs the spike protein’s ability to attach to the ACE2 receptor on human cell membranes, preventing viral entry. Moreover, the drug prevents blood clots

Life, though, really means a cell membrane. In biology, what defines life is the ability to self-reproduce. And only things with cell membranes can reproduce on their own.

Phosphatidylserine. This is essential for nerve cell membranes, and also supports cognition, including the formation of short-term memory, the consolidation of long-term memory, the ability to create new memories, and the ability to retrieve memories.[57] Supplementation with phosphatidylserine has been shown to lower cortisol levels by normalizing stress-induced dysregulation of the hypothalamus-pituitary-adrenal axis.[58] Suggested Dosage: 100 to 500g taken before each high cortisol episode Ashwagandha. This is also known as Withania somnifera, and it is an adaptogenic herb. It supports both the HPA and hypothalamic-pituitary-thyroid (HPT) axes. Thus, it can help people who have HPA axis dysregulation because of chronic stress, and by supporting the HPT axis it can also benefit thyroid function. As I mentioned in Chapter 27, ashwagandha is part of the nightshade (Solanaceae) family, and nightshades are excluded from an autoimmune Paleo diet. Ashwagandha can help with sleep issues by lowering cortisol levels, although one study showed that this herb might help with insomnia by increasing levels of the neurotransmitter GABA.[59] Suggested Dosage: 250 to 500mg taken before each high cortisol episode

In thearpy, I had learned about selective permeability, a term that pertains to cellular membranes letting some, but not all molecules enter the cell. The same can apply to interaction with people. Not taking on the experience or negative of other, but staying open to accepting joy or gratitude.

The Human Heart CONSIDER, FOR example, the human heart and its accompanying circulatory system. The human heart is vastly superior to any human artifact. Every second it undergoes a cycle of contraction and expansion, and beats continually and faithfully for the duration of a human lifetime. It starts beating in the womb and in eighty years will beat about two billion times. The cardiac muscle itself consists of an interconnected syncytium of billions of muscle cells specially adapted to resist fatigue and contract autonomously without external activation or control. Within the cardiac muscle cells there are trillions of tightly packed molecular arrays of contractile filaments whose regular rhythmic lengthening and shortening generate the cardiac cycle. At rest each of us needs about a fourth a liter of oxygen per minute to satisfy our energy needs.30 This involves the movement every minute of one hundred trillion oxygen molecules across every square millimeter of the alveolar surface of the lungs. And with every contraction the heart pumps one hundred billion red blood cells through hundreds of kilometers of tiny capillaries.31 Coursing through the capillaries in the lungs, each of these tiny nano-machines carries one billion molecules of oxygen (O2) from the lungs to the tissues, each loosely bound to an iron atom in the hemoglobin. By the heart’s unceasing activity it ensures a bountiful supply of oxygen to provide us with the vital energy of life. The red cells themselves, no less than the heart, are also miracles of bioengineering. During its 120-day lifetime in the circulatory system, each red cell makes hundreds of thousands of circuits, covering hundreds of miles. It is only because the red cell membranes are uniquely soft and strong—one hundred times softer than a latex membrane of comparable thickness but stronger than steel32—that they can withstand these repeated deformations as they squeeze though the smallest capillaries, which in many cases have a diameter of five microns, almost half the diameter of the average red blood cell.

For example, a March 2021 study18 by Choudhury et al., found that “Ivermectin was found as a blocker of viral replicase, protease and human TMPRSS2, which could be the biophysical basis behind its antiviral efficiency.” The drug also reduces inflammation via multiple pathways, thereby protecting against organ damage. Ivermectin furthermore impairs the spike protein’s ability to attach to the ACE2 receptor on human cell membranes, preventing viral entry. Moreover, the drug prevents blood clots through binding to spike protein, and also deters the spike protein from binding to CD147 on red blood cells, which would otherwise trigger clumping. When patients take IVM before exposure, the drug prevents infection, which halts onward transmission, and helps protect the entire community.