Cdr Quotes

One runs the risk of weeping a little, if one lets himself be tamed

Within Room 40 itself, however, management of day-to-day operations fell largely, if informally, to Cdr. Herbert Hope, recruited in November 1914 to bring naval expertise to the interpretation of intercepted messages. His savvy was badly needed, for the group’s staff were not navy officers but civilians recruited for their skill at mathematics and German and whatever else it was that made a man good at breaking codes and ciphers. The roster came to include a pianist, a furniture expert, a parson from northern Ireland, a wealthy London financier, a past member of the Scottish Olympic hockey team, and a dapper operative named C. Somers Cocks, who, according to one early member, William F. Clarke, was “chiefly remarkable for his spats.

00 11 20 14 CC Apollo 13, Houston. 00 11 20 18 CDR Go ahead, Houston. 00 11 20 19 CC Okay. Looking at our computations back here, we show you about 55 450 and going out rapidly now. 00 11 20 33 CDR Well, Hal might be a little bit off. 00 11 20 36 CC Okay. 00 11 20 37 CMP We have a sign underneath our LEB DSKY that "my name is Hal." 00 11 20 45 CC I can't imagine how that got there. Just remember, you have to be nice to Hal. 00 11 20 55 CMP We will.

declarer.declareStream("car", new Fields("first")); declarer.declareStream("cdr", new Fields(

Somatic hypermutation gives rise to B cells bearing mutant immunoglobulin molecules on their surface. Some of these mutant immunoglobulins have substitutions in the antigen-binding site that increase its affinity for the antigen. B cells bearing these mutant high-affinity immunoglobulin receptors compete most effectively for binding to antigen and are preferentially selected to mature into antibody-secreting plasma cells. The mutant antibodies that emerge from the selection do not have a random distribution of amino-acid substitutions. The changes are concentrated at positions in the heavy-chain and light-chain CDR loops that form the antigen-binding site and directly contact antigen. As the adaptive immune response to infection proceeds, antibodies of progressively higher affinity for the infecting pathogen are produced – a phenomenon called affinity maturation. Affinity maturation is a process of evolution in which variant immunoglobulins generated in a random manner are subjected to selection for improved binding to a pathogen. It achieves in a few days what would require thousands, if not millions, of years of classical Darwinian evolution in a conventional gene. This capacity for extraordinarily rapid evolution in pathogen-binding immunoglobulins is a major factor in allowing the human immune system to keep up with the generally faster-evolving pathogens.

I was just about to suggest to Barry that we stop for a moment and go rescue Marguerite when I realized it was too late.      Marguerite was carrying a small evening bag, like a clutch purse, and I saw her wind up and throw it down onto the floor.  At the same time I heard her almost scream, “ALL RIGHT YOU SONOFABITCH, I DON’T WANT TO HEAR ANOTHER WORD!!”  It was loud enough that everyone heard her and even the band stopped to see what was going on.      With the index finger of her right hand she began poking this guy in the center of his chest and backing him up at the same time, all the while shouting at the top of her lungs, “If it wasn’t for the UNITED STATES OF AMERICA and the men who fought and died to help keep your country free, YOU would be living on the tiniest GERMAN SPEAKING ISLAND OF THE THIRD REICH!!!  DON’T EVER LET ME HEAR YOU SAY ANYTHING BAD ABOUT MY COUNTRY AGAIN, IN FACT DON’T EVER SAY ANYTHING TO ME AGAIN, NOD IF YOU UNDERSTAND !!!”       She had pushed him back against the bar and he was now leaning over backwards about as far as he could lean and she was still poking him in the chest.  The room was completely silent.  I said to Barry, “Excuse me a moment Barry, I think I need to go rescue one of your countrymen.”      She chuckled and said, “I doubt if anyone will care if you rescue that one.”      I went straight for Marguerite and the terrified LtCdr bent backwards over the bar.  As I approached them I scooped up her purse from the floor and said, “I believe this next dance is mine my dear.” I gave her my arm and we headed for the center of the dance floor and as we did the band started back up.  Everyone else picked right back up where they’d left off.     About twenty minutes later the Commander came up to us.  I had no idea what to expect but he had big smile on his face.      “William, I just wanted to thank you and your good lady for that lovely cocktail party at your quarters this evening and tell you how smart you both look in your ball outfits.  AND Marguerite, I think if we took a vote right now, most everyone in the room would want to award you a medal for setting that ‘Bloody’ man straight.  Well done.

Success has many fathers, Failure is an orphan !

The substrates within each CDR that are frequently seen mutated are defined as “hotspots”. They are described by preferences for purines, rather than pyrimidines, as well as for particular codons, or codon motifs within the sequence. The fact that mutation in a hotspot can create or delete other hotspots indicates a higher order structure to the mutation process than that which is currently observable. McKay Brown, Mary Stenzel-Poore, Susan Stevens, Sophia K. Kondoleon, James Ng, Hans Peter Bachinger, and Marvin B. Rittenberg. Immunologic memory to phosphocholine keyhole limpet hemocyanin. Journal of Immunology, 148(2):339–346, January 1992.

Para trabajar por la defensa nacional, llama a su pueblo a crear Círculos Bolivarianos en cada barrio, en cada organización. Ésta es su versión de los legendarios Comités de Defensa de la Revolución, los CDR, que instauró Fidel al principio de su largo gobierno:

what CDR stood for—call detail records.