Cardiovascular Disease Related Quotes

It’s the combination of fat and a relatively high intake of carbohydrates—particularly refined ones—that can become a deadly recipe for obesity, diabetes, cardiovascular disease, and a host of other ills.

Calorie restriction extends the life span of every organism so far tested, including yeast, worms, flies, rodents, and monkeys. It also slows or even prevents age-related diseases, including dementia, diabetes, cardiovascular and coronary disease, neurodegenerative disorders, and several types of cancer.

One last bit of bad news. We’ve been focusing on the stress-related consequences of activating the cardiovascular system too often. What about turning it off at the end of each psychological stressor? As noted earlier, your heart slows down as a result of activation of the vagus nerve by the parasympathetic nervous system. Back to the autonomic nervous system never letting you put your foot on the gas and brake at the same time—by definition, if you are turning on the sympathetic nervous system all the time, you’re chronically shutting off the parasympathetic. And this makes it harder to slow things down, even during those rare moments when you’re not feeling stressed about something. How can you diagnose a vagus nerve that’s not doing its part to calm down the cardiovascular system at the end of a stressor? A clinician could put someone through a stressor, say, run the person on a treadmill, and then monitor the speed of recovery afterward. It turns out that there is a subtler but easier way of detecting a problem. Whenever you inhale, you turn on the sympathetic nervous system slightly, minutely speeding up your heart. And when you exhale, the parasympathetic half turns on, activating your vagus nerve in order to slow things down (this is why many forms of meditation are built around extended exhalations). Therefore, the length of time between heartbeats tends to be shorter when you’re inhaling than exhaling. But what if chronic stress has blunted the ability of your parasympathetic nervous system to kick the vagus nerve into action? When you exhale, your heart won’t slow down, won’t increase the time intervals between beats. Cardiologists use sensitive monitors to measure interbeat intervals. Large amounts of variability (that is to say, short interbeat intervals during inhalation, long during exhalation) mean you have strong parasympathetic tone counteracting your sympathetic tone, a good thing. Minimal variability means a parasympathetic component that has trouble putting its foot on the brake. This is the marker of someone who not only turns on the cardiovascular stress-response too often but, by now, has trouble turning it off.

HUNGER AND OBESITY The change in diets around the world is also creating a global obesity epidemic—and in its wake a global diabetes epidemic—even as more than 900 million people in the world still suffer from chronic hunger. In the United States, where many global trends begin, the weight of the average American has increased by approximately twenty pounds in the last forty years. A recent study projects that half the adult population of the United States will be obese by 2030, with one quarter of them “severely obese.” At a time when hunger and malnutrition are continuing at still grossly unacceptable levels in poor countries around the world (and in some pockets within developed countries), few have missed the irony that simultaneously obesity is at record levels in developed countries and growing in many developing countries. How could this be? Well, first of all, it is encouraging to note that the world community has been slowly but steadily decreasing the number of people suffering from chronic hunger. Secondly, on a global basis, obesity has more than doubled in the last thirty years. According to the World Health Organization, almost 1.5 billion adults above the age of twenty are overweight, and more than a third of them are classified as obese. Two thirds of the world’s population now live in countries where more people die from conditions related to being obese and overweight than from conditions related to being underweight. Obesity represents a major risk factor for the world’s leading cause of death—cardiovascular diseases, principally heart disease and stroke—and is the major risk factor for diabetes, which has now become the first global pandemic involving a noncommunicable disease.* Adults with diabetes are two to four times more likely to suffer heart disease or a stroke, and approximately two thirds of those suffering from diabetes die from either stroke or heart disease.† The tragic increase in obesity among children is particularly troubling; almost 17 percent of U.S. children are obese today, as are almost 7 percent of all children in the world. One respected study indicates that 77 percent of obese children will suffer from obesity as adults. If there is any good news in the latest statistics, it is that the prevalence of obesity in the U.S. appears to be reaching a plateau, though the increases in childhood obesity ensure that the epidemic will continue to grow in the future, both in the U.S. and globally. The causes of this surge in obesity are both simple—in that people are eating too much and exercising

Cardiovascular disease affects women as well as men. Women actually outnumber men in the prevalence of cases of cardiovascular disease and in related deaths, with about 53 percent of the deaths from cardiovascular disease occurring in women. Although studies repeatedly show that women are much more anxious about developing breast cancer than cardiovascular disease, one of every 2.4 deaths in women is caused by cardiovascular disease, compared to one in thirty from breast cancer.

Low Risk of Cardiovascular Disease - Less than 1 mg/L Moderate Risk of Cardiovascular Disease - 1 to 2.9 mg/L High Risk of Cardiovascular Disease - 3 or higher mg/L Further Testing Suggested to Find out the Cause of Severe Inflammation - 10 or higher mg/L CRP-HS (C-Reactive High Sensitivity) Lower Relative Risk - Less than 1.0 Average Relative Risk - Average Risk TSH (Thyroid Stimulating Hormone) Normal Range - 0.4 to 4.2 ml/L T4 (Free Thyroid) Normal Range - 0.78 to 2.19 ng/dL T4 (Total Thyroid) Normal Range – 5.53 to 11.00 mcg/dL T3 (Free Thyroid) Normal Range - 2.5 to 5.3 pg/mL SECTION 2

The following are guidelines for people at high risk of developing dementias (given family history or early cognitive decline): Adopt the Longevity Diet and the periodic FMD. Incorporate plenty of olive oil (50 milliliters per day) and nuts (30 grams per day). Drink coffee. For people at relatively low risk of AD, keep it to one or two cups a day; for people at high risk, drink up to three or four cups a day. Speak to your doctor if you have problems. Take 40 milliliters of coconut oil per day but consider potential heart disease risk (people with or at risk for cardiovascular disease should not use coconut oil). Avoid saturated fats and trans fats. Avoid all animal-based products with the exception of low-mercury fish and cheese or other dairy products from goat’s milk. Follow a high-nourishment diet containing omega-3, B vitamins, and vitamins C, D, and E. Take a multivitamin and mineral every day.

Oil Is Not a Whole, Natural Food and Does Not Grow on Trees Although vegetable oils (such as olive, sesame, soybean, and canola oils) are relatively low in saturated fat and higher in unsaturated fats, you should use these processed foods minimally or not at all. Oils lack the beneficial factors that whole nuts and seeds contain. Nuts and seeds contain fiber, minerals, antioxidants, and other phytochemicals in addition to healthy fats that contribute to cardiovascular health.60 Most of these nutrients are missing in refined oils.

the Horsemen: cardiovascular and cerebrovascular disease, cancer, Alzheimer’s disease and related neurodegenerative conditions, and type 2 diabetes and related metabolic dysfunction.

CRP is turning out to be a much better predictor of cardiovascular disease risk than cholesterol, even years in advance of disease onset. As a result, CRP has suddenly become quite trendy in medicine, and is fast becoming a standard endpoint to measure in general blood work on patients.

Cedar Capital Group Tokyo Review of Stats Shows Decrease in Mortality Rate in Construction Sites Cedar Capital Group in Tokyo Japan construction industry is one of the riskiest industries to work with. Not only do they have to deal with falling debris but workers also have to be aware of faulty wirings, defective equipment and weather warnings. Workers even sometimes have to lose their lives in the midst of construction. These circumstances are inevitable and precautions were already implemented even at the start of training. Yet, it cannot be denied that construction is one of the most lucrative businesses in the world today. Everywhere we go, we see buildings being built and establishments being constructed. We see new structures in developed nations. New York, America, Tokyo, Japan, Beijing, China and Seoul, South Korea are some of the leading cities which feature new construction projects almost everyday. Singapore is also not left behind. Considered as one of the most flourishing countries in the world, the little island-city has prided itself with new infrastructure projects and promise a thousand more to come. It came no surprise that the country’s journey towards urbanization was held liable for the deaths of hundreds of construction workers in the previous years. Just recently, though, Singapore has declared their concern on the number of fatalities there are in a construction project. If not of deaths, accidents resulting to fractures and minor and major injuries are also experienced in other neighboring countries. Cedar Capital Group in Tokyo Japan, one the distributor of heavy capital equipment in the country, reports to have dozens of death in the last 4 years of their operation. This, as they claim, is one of the reasons why there is a large scarcity in job application related to construction. Many companies are also faced with numerous complaints because of these deaths and injuries. According to further review, approximately one-quarter of the deaths result from exposure to hazardous substances which cause such disabling illnesses as cancer and cardiovascular, respiratory and nervous-system disorders. Analysts even warn that work-related diseases are expected to double by the year 2020 and that if improvements are not implemented now, exposures today will kill people by the year 2020. Surprisingly, though, while people are being troubled with the number of casualties in the construction sector, recent studies and statistics show fewer deaths in construction sector in the first half of the year. Specifically in Singapore, Manpower Ministry has announced only 8 death reports compared to the 17 deaths in 2014. Although this is not a reason to celebrate since there are still fatalities, Singapore’s Contractual Association stated that this is an improvement as it shows the effectiveness of the recent awareness programs and training seminars conducted across the island-city. The country aims to clear all fatalities for the next succeeding years.

knowledge of cardiovascular disease and whether such knowledge reduces behaviors that put people at risk for cardiovascular disease. Simple regression is used to analyze the relationship between two continuous variables. Continuous variables assume that the distances between ordered categories are determinable.1 In simple regression, one variable is defined as the dependent variable and the other as the independent variable (see Chapter 2 for the definitions). In the current example, the level of knowledge obtained from workshops and other sources might be measured on a continuous scale and treated as an independent variable, and behaviors that put people at risk for cardiovascular disease might also be measured on a continuous scale and treated as a dependent variable. Scatterplot The relationship between two continuous variables can be portrayed in a scatterplot. A scatterplot is merely a plot of the data points for two continuous variables, as shown in Figure 14.1 (without the straight line). By convention, the dependent variable is shown on the vertical (or Y-) axis, and the independent variable on the horizontal (or X-) axis. The relationship between the two variables is estimated as a straight line relationship. The line is defined by the equation y = a + bx, where a is the intercept (or constant), and b is the slope. The slope, b, is defined as Figure 14.1 Scatterplot or (y2 – y1)/(x2 – x1). The line is calculated mathematically such that the sum of distances from each observation to the line is minimized.2 By definition, the slope indicates the change in y as a result of a unit change in x. The straight line, defined by y = a + bx, is also called the regression line, and the slope (b) is called the regression coefficient. A positive regression coefficient indicates a positive relationship between the variables, shown by the upward slope in Figure 14.1. A negative regression coefficient indicates a negative relationship between the variables and is indicated by a downward-sloping line. Test of Significance The test of significance of the regression coefficient is a key test that tells us whether the slope (b) is statistically different from zero. The slope is calculated from a sample, and we wish to know whether it is significant. When the regression line is horizontal (b = 0), no relationship exists between the two variables. Then, changes in the independent variable have no effect on the dependent variable. The following hypotheses are thus stated: H0: b = 0, or the two variables are unrelated. HA: b ≠ 0, or the two variables are (positively or negatively) related. To determine whether the slope equals zero, a t-test is performed. The test statistic is defined as the slope, b, divided by the standard error of the slope, se(b). The standard error of the slope is a measure of the distribution of the observations around the regression slope, which is based on the standard deviation of those observations to the regression line: Thus, a regression line with a small slope is more likely to be statistically significant when observations lie closely around it (that is, the standard error of the observations around the line is also small, resulting in a larger test statistic). By contrast, the same regression line might be statistically insignificant when observations are scattered widely around it. Observations that lie farther from the

Those with cardiovascular disease not identified with diabetes are simply undiagnosed. Dr. Stout in 1977 identified the origin of the pathology of type 2 diabetes as vascular (arterial), directly related to hyperinsulinemia and not to hypergly-cemia.

Estradiol—Estradiol is the strongest estrogen; it helps you think clearly. It is produced in the ovaries and has many protective effects, including maintaining bone density, improving growth hormone production and cardiovascular function, keeping your blood from getting “sticky,” supporting cognitive function and mood, assisting in growth hormone release, and improving your lipids profile. Too much estradiol can be associated with estrogen-related cancers, but deficiencies can lead to osteoporosis, heart disease, dementia, and other diseases of aging. Estradiol keeps you looking and feeling young and vibrant. It also provides antiaging protection for the skin. And it even helps prevent weight gain. Researchers at Yale University have found that estradiol suppresses appetite using the same pathways in the brain as leptin, which is one of the hormones that regulate appetite.

So you’re sprinting down the street with the lion after you. Things looked grim for a moment there, but—your good luck—your cardiovascular system kicked into gear, and now it is delivering oxygen and energy to your exercising muscles. But what energy? There’s not enough time to consume a candy bar and derive its benefits as you sprint along; there’s not even enough time to digest food already in the gut. Your body must get energy from its places of storage, like fat or liver or non-exercising muscle. To understand how you mobilize energy in this circumstance, and how that mobilization can make you sick at times, we need to learn how the body stores energy in the first place.

China is perhaps the best-studied example. There, a transition away from the country’s traditional, plant-based diet was accompanied by a sharp rise in diet-related chronic diseases, such as obesity, diabetes, cardiovascular diseases, and cancer.38

Vitamin D3 boasts a strong safety profile, along with broad and deep evidence that links it to brain, metabolic, cardiovascular, muscle, bone, lung, and immune health. New and emerging research suggests that vitamin D supplements may also slow down our epigenetic/biological aging.29, 30 2. Omega-3 fish oil: Over the last thirty years or so, the typical Western diet has added more and more pro-inflammatory omega-6 polyunsaturated fatty acids versus anti-inflammatory omega-3 PUFAs. Over the same period, we’ve seen an associated rise in chronic inflammatory diseases, including obesity, cardiovascular disease, rheumatoid arthritis, and Alzheimer’s disease. 31 Rich in omega-3s, fish oil is another incredibly versatile nutraceutical tool with multi-pronged benefits from head to toe. By restoring a healthier PUFA ratio, it especially helps your brain and heart. Regular consumption of fatty fish like salmon has been linked to a lower risk of congestive heart failure, coronary heart disease, sudden cardiac death, and stroke.32 In an observational study, omega-3 fish oil supplementation was also associated with a slower biological clock.33 3. Magnesium deficiency affects more than 45 percent of the U.S. population. Supplements can help us maintain brain and cardiovascular health, normal blood pressure, and healthy blood sugar metabolism. They may also reduce inflammation and help activate our vitamin D. 4. Vitamin K1/K2 supports blood clotting, heart/ blood vessel health, and bone health.34 5. Choline supplements with brain bioavailability, such as CDP-Choline, citicoline, or alpha-GPC, can boost your body’s storehouse of the neurotransmitter acetylcholine and possibly support liver and brain function, while protecting it from age-related insults.35 6. Creatine: This one may surprise you, since it’s often associated with serious athletes and fitness buffs. But according to Dr. Lopez, it’s “a bona fide arrow in my longevity nutraceutical quiver for most individuals, and especially older adults.” As a coauthor of a 2017 paper by the International Society for Sports Nutrition, Dr. Lopez, along with contributors, stated that creatine not only enhances recovery, muscle mass, and strength in connection with exercise, but also protects against age-related muscle loss and various forms of brain injury.36 There’s even some evidence that creatine may boost our immune function and fat and carbohydrate metabolism. Generally well tolerated, creatine has a strong safety profile at a daily dose of three to five grams.37 7.

much longer-lasting adverse effect of the pandemic: the fact that Americans who were in utero during the pandemic had, over the course of their lives, reduced educational attainment, higher rates of physical disability, and lower income relative to those who went through fetal development immediately before or after.119 Those born at the crests of the three waves also had higher lifetime risk from respiratory and cardiovascular diseases.120 Similar impacts on fetal development have also been found for other countries, including Brazil, Italy, Norway, Sweden,121 Switzerland, and Taiwan.122 There is also some evidence that the Spanish flu eroded social trust in the countries most adversely affected.123

One quick note: diabetes ranks as only the seventh or eighth leading cause of death in the United States, behind things like kidney disease, accidents, and Alzheimer’s disease. In 2020, a little more than one hundred thousand deaths were attributed to type 2 diabetes, a fraction of the number due to either cardiovascular disease or cancer. By the numbers, it barely qualifies as a Horseman. But I believe that the actual death toll due to type 2 diabetes is much greater and that we undercount its true impact. Patients with diabetes have a much greater risk of cardiovascular disease, as well as cancer and Alzheimer’s disease and other dementias; one could argue that diabetes with related metabolic dysfunction is one thing that all these conditions have in common.

And, even more important for our purposes, these facts are sturdy enough that we can build a sensible diet upon them. Here they are: FACT 1. Populations that eat a so-called Western diet—generally defined as a diet consisting of lots of processed foods and meat, lots of added fat and sugar, lots of refined grains, lots of everything except vegetables, fruits, and whole grains—invariably suffer from high rates of the so-called Western diseases: obesity, type 2 diabetes, cardiovascular disease, and cancer. Virtually all of the obesity and type 2 diabetes, 80 percent of the cardiovascular disease, and more than a third of all cancers can be linked to this diet. Four of the top ten killers in America are chronic diseases linked to this diet. The arguments in nutritional science are not about this well-established link; rather, they are all about identifying the culprit nutrient in the Western diet that might be responsible for chronic diseases. Is it the saturated fat or the refined carbohydrates or the lack of fiber or the transfats or omega-6 fatty acids—or what? The point is that, as eaters (if not as scientists), we know all we need to know to act: This diet, for whatever reason, is the problem. FACT 2. Populations eating a remarkably wide range of traditional diets generally don’t suffer from these chronic diseases. These diets run the gamut from ones very high in fat (the Inuit in Greenland subsist largely on seal blubber) to ones high in carbohydrate (Central American Indians subsist largely on maize and beans) to ones very high in protein (Masai tribesmen in Africa subsist chiefly on cattle blood, meat, and milk), to cite three rather extreme examples. But much the same holds true for more mixed traditional diets. What this suggests is that there is no single ideal human diet but that the human omnivore is exquisitely adapted to a wide range of different foods and a variety of different diets. Except, that is, for one: the relatively new (in evolutionary terms) Western diet that most of us now are eating. What an extraordinary achievement for a civilization: to have developed the one diet that reliably makes its people sick! (While it is true that we generally live longer than people used to, or than people in some traditional cultures do, most of our added years owe to gains in infant mortality and child health, not diet.) There is actually a third, very hopeful fact that flows from these two: People who get off the Western diet see dramatic improvements in their health. We have good research to suggest that the effects of the Western diet can be rolled back, and relatively quickly.

from human studies of the Horsemen: cardiovascular and cerebrovascular disease, cancer, Alzheimer’s disease and related neurodegenerative conditions, and type 2 diabetes and related metabolic dysfunction.

Our skin, blood vessels, and bones are all connected; hence, wrinkles, cardiovascular disease, and osteoporosis can be viewed as related symptoms. Of course, it is not only vitamin K that plays a role in all this. It also does not mean that everyone with lots of wrinkles has osteoporosis. But can vitamin K help prevent wrinkles? More research is needed to see if that is possible.

vitamin K also makes the mitochondria function better. That is a good thing because the longer our mitochondria remain healthy, the slower we age.163 That is also one reason that sufficient intake of vitamin K decreases the risk of typical aging-related diseases, such as Alzheimer’s disease, diabetes, and cardiovascular disease.164

As with countless Greek tragedies, the end result was heartbreaking, but here in the most serious, literal way. None of the individuals had a history of coronary heart disease or stroke at the start of the study, indicating the absence of cardiovascular ill health. However, those that abandoned regular siestas went on to suffer a 37 percent increased risk of death from heart disease across the six-year period, relative to those who maintained regular daytime naps. The effect was especially strong in workingmen, where the ensuing mortality risk of not napping increased by well over 60 percent.

We now understand how vitamin K2 directly relates to cardiovascular disease. Vitamin K2 helps in removing calcium deposits from arteries. Why is this so significant?

The Centers for Disease Control and Prevention (CDC) recently asked the Institute of Medicine (IOM) to reevaluate the evidence relating to sodium intake and cardiovascular risk, and its 2013 report found that there was no benefit for restricting sodium intake below 2,300 milligrams per day. In fact, it found that there may be adverse health outcomes.

Most people today live in relatively constant distress and anxiety. This is related to a low-grade but perpetual fight-or-flight response masterminded by the Judge in reaction to the challenges of life, both personal and professional. Though the fight-or-flight response originally evolved to get us out of acute, short-term danger, most of us run the Survivor Brain continuously. The consequence of this perpetual stress and anxiety is heightened blood pressure, increased cardiovascular disease, reduced immune system function, reduced longevity, and reduced happiness and performance.

Top Skills Australia Wants for the Global Talent Visa The Global Talent Visa (subclass 858) is one of Australia’s most prestigious visa programs, designed to attract highly skilled professionals who can contribute to the country’s economy and innovation landscape. Australia is looking for exceptional talent across various sectors to support its economic growth, technological advancements, and cultural development. If you’re considering applying for the Global Talent Visa, understanding the skills in demand will help you position yourself as a strong candidate. In this blog, we’ll outline the top skills and sectors Australia prioritizes for the Global Talent Visa, and why these skills are so valuable to the country’s future development. 1. Technology and Digital Innovation Australia is rapidly embracing digital transformation across industries, and the technology sector is one of the highest priority areas for the Global Talent Visa. Skilled professionals in cutting-edge technologies are highly sought after to fuel innovation and help Australia stay competitive in the global economy. Key Tech Skills in Demand: Cybersecurity: With increasing cyber threats globally, Australia needs experts who can safeguard its digital infrastructure. Cybersecurity professionals with expertise in network security, data protection, and ethical hacking are in high demand. Software Development & Engineering: Australia’s digital economy thrives on skilled software engineers and developers. Professionals who are proficient in programming languages like Python, Java, and C++, or who specialize in areas such as cloud computing, DevOps, and systems architecture, are highly valued. Artificial Intelligence (AI) & Machine Learning (ML): AI and ML are transforming industries ranging from healthcare to finance. Experts in AI algorithms, natural language processing, deep learning, and neural networks are in demand to help drive this technology forward. Blockchain & Cryptocurrency: Blockchain technology is revolutionizing sectors like finance, supply chains, and data security. Professionals with expertise in blockchain development, smart contracts, and cryptocurrency applications can play a key role in advancing Australia's digital economy. 2. Healthcare and Biotechnology Australia has a robust and expanding healthcare system, and the country is heavily investing in medical research and biotechnology to meet the needs of its aging population and to drive innovation in health outcomes. Professionals with advanced skills in biotechnology, medtech, and pharmaceuticals are crucial to this push. Key Healthcare & Bio Skills in Demand: Medical Research & Clinical Trials: Australia is home to a growing number of research institutions that focus on new treatments, vaccines, and therapies. Researchers and professionals with experience in clinical trials, molecular biology, and drug development can contribute to the ongoing advancement of Australia’s healthcare system. Biotechnology & Genomics: Experts in biotechnology, particularly those working in genomics, gene editing (e.g., CRISPR), and personalized medicine, are highly sought after. Australia is investing heavily in biotech innovation, especially for treatments related to cancer, cardiovascular diseases, and genetic disorders. MedTech Innovation: Professionals developing the next generation of medical technologies—ranging from diagnostic tools and medical imaging to wearable health devices and robotic surgery systems—are in high demand. If you have experience in health tech commercialization, you could find significant opportunities in Australia.