Brain Impairment Quotes

Being cut off from our own natural self-compassion is one of the greatest impairments we can suffer. Along with our ability to feel our own pain go our best hopes for healing, dignity and love. What seems nonadapative and self-harming in the present was, at some point in our lives, an adaptation to help us endure what we then had to go through. If people are addicted to self-soothing behaviours, it's only because in their formative years they did not receive the soothing they needed. Such understanding helps delete toxic self-judgment on the past and supports responsibility for the now. Hence the need for compassionate self-inquiry.

It’s a subtle thing, freedom. It takes effort; it takes attention and focus to not act something like an automaton. Although we do have freedom, we exercise it only when we strive for awareness, when we are conscious not just of the content of the mind but also of the mind itself as a process.’ We may say, then, that in the world of the psyche, freedom is a relative concept: the power to choose exists only when our automatic mechanisms are subject to those brain systems that are able to maintain conscious awareness. A person experiences greater or less freedom from one situation to the next, from one interaction to the next, from one moment to the next. Anyone whose automatic brain mechanisms habitually run in overdrive has diminished capacity for free decision making, especially if the parts of the brain that facilitate conscious choice are impaired or underdeveloped.

I'm staring and I need to stop, but seeing her inhibits brain function. Girls don't know it, but standing in the presence of beauty impairs guys. At least, it impairs me. Screw it. It's Lila. Lila impairs me.

Genetics, accidents of birth or events in early childhood have left criminals' brains and bodies with measurable flaws predisposing them to committing assault, murder and other antisocial acts. .... Many offenders also have impairments in their autonomic nervous system, the system responsible for the edgy, nervous feeling that can come with emotional arousal. This leads to a fearless, risk-taking personality, perhaps to compensate for chronic under-arousal. Many convicted criminals, like the Unabomber, have slow heartbeats. It also gives them lower heart rates, which explains why heart rate is such a good predictor of criminal tendencies. The Unabomber, Ted Kaczynski, for example, had a resting heart rate of just 54 beats per minute, which put him in the bottom 3 per cent of the population.

The disappearance of medial prefrontal activation could explain why so many traumatized people lose their sense of purpose and direction. I used to be surprised by how often my patients asked me for advice about the most ordinary things, and then by how rarely they followed it. Now I understood that their relationship with their own inner reality was impaired. How could they make decisions, or put any plan into action, if they couldn't define what they wanted or, to be more precise, what the sensations in their bodies, the basis of all emotions, were trying to tell them?

a messy environment taxes the brain. When surrounded by clutter, our brains are so busy registering all the things around us that we can’t focus on what we should be doing in the moment, such as tackling the work on our desk or communicating with others. We feel distracted, stressed, and anxious, and our decision-making ability is impaired.

Dopamine and constant stimulation can impair your ability to think long term

Impaired social interactions and withdrawal may not be the result of a lack of compassion, incapability to put oneself into someone else’s position or lack of emotionality

curing’ victims of multiple-personality disorder is actually tantamount to serial murder. The issue has remained controversial in the wake of recent findings that the human brain can potentially contain up to one hundred forty fully-sentient personalities without significant sensory/motor impairment. The tribunal will also consider whether encouraging a multiple personality to reintegrate voluntarily—again, a traditionally therapeutic act—should be redefined as assisted suicide. Cross-linked to next item under cognition and legal.

When stress becomes sustained over long periods, our brain tends towards more habitual behaviours that demand less energy. Our ability to control our impulses, remember information and make decisions becomes impaired. Over time, our immune system is affected.

Brain-imaging studies and psychological testing indicate that the same areas are also impaired in drug addiction. And what is the result? If it wasn’t enough that powerful incentive and reward mechanisms drive the craving for drugs, on top of that the circuits that could normally inhibit and control those mechanisms are not up to their task. In fact, they are complicit in the addiction process. A double whammy: the watchman is aiding the thieves.

Even mild dehydration can cause headaches and fatigue, affect your concentration, impair short-term memory and impede mental function. If you want to be at your most productive, it’s important for your brain to be firing on all cylinders. Therefore, you should make sure you are sufficiently hydrated before starting work.

One of the most bizarre and intriguing findings is that people with brain damage may be particularly good investors. Why? Because damage to certain parts of the brain can impair the emotional responses that cause the rest of us to do foolish things. A team of researchers from Carnegie Mellon, Stanford, and the University of Iowa conducted an experiment that compared the investment decisions made by fifteen patients with damage to the areas of the brain that control emotions (but with intact logic and cognitive functions) to the investment decisions made by a control group. The brain-damaged investors finished the game with 13 percent more money than the control group, largely, the authors believe, because they do not experience fear and anxiety. The impaired investors took more risks when there were high potential payoffs and got less emotional when they made losses.7 This

Toxic stress response can occur when a child experiences strong, frequent, and/or prolonged adversity—such as physical or emotional abuse, neglect, caregiver substance abuse or mental illness, exposure to violence, and/or the accumulated burdens of family economic hardship—without adequate adult support. This kind of prolonged activation of the stress-response systems can disrupt the development of brain architecture and other organ systems, and increase the risk for stress-related disease and cognitive impairment, well into the adult years.

Cannabis affects the brain because brain cells themselves produce cannabis-like neurotransmitters. The first such compound to be identified was christened anandamide, ananda being Sanskrit for “bliss.” The proteins that transmit anandamide’s message to the brain, the receptors, are mainly located in the striatum (hence the blissful feeling) and in the cerebellum (hence the unsteady gait after taking marijuana), in the cerebral cortex (hence the problems with association, the fragmented thoughts and confusion), and in the hippocampus (hence the memory impairment). But there are no receptors in the brain stem areas that regulate blood pressure and breathing. That’s why it’s impossible to take an overdose of cannabis, as opposed to opiates.

Inadequate sleep impairs brain functioning, including working memory and long-term memory, attention, decision-making, hand-eye coordination, calculation accuracy, logical reasoning, and creativity.20 People who’ve been awake for nineteen hours (say, woke up at 7 A.M. and now it’s 2 A.M.) are as impaired in their cognitive and motor functioning as a person who is legally intoxicated.21 People who’ve slept just four hours the previous night are similarly impaired, as are those who’ve slept six or fewer hours every night for the last two weeks. Anything you wouldn’t do drunk—drive, lead a work meeting, raise a child—don’t try it if you’ve been awake for nineteen hours, slept only four hours the previous night, or slept fewer than six hours every night for two weeks.

ADHD impairments: in brain chemistry dynamics; chronic procrastination due to; in coordination of brain rhythms; delays in brain maturation; as developmental delay or ongoing impairment; executive function clusters affected by fig; frustrations in marriage; how they affect processing of emotions; impact on employment; impacting ability to sustain treatment; impaired brain connectivity; impaired cognitive functioning; James' story on identifying; for managing conflicting or unrecognized emotions; working memory and. See also People with ADHD; specific executive function cluster

the dysregulation of the body’s neurobiological system, that impairs one’s ability to pay selective attention to one’s surroundings. The world becomes a land without street signs, the individual a car in bad need of a tune-up. The vastness of the attentional system partially accounts for the variation of ADD “types.” Where one individual needs an oil change, the next needs spark plugs replaced. Where one individual is withdrawn and overwhelmed by stimuli, the next is hyperactive and can’t get enough stimuli. Where one is frequently anxious, the other is depressed. To compensate, each develops his or her own coping strategies that developmentally add to, or subtract from, the brain’s various subsystems. So Mr. A becomes a stand-up comedian, and manic. Ms. B becomes an architectural wizard with obsessive-compulsive traits. Their offspring become a sculptor and a stunt pilot. None of them can balance their checkbook. And all of them wish they had more time in the day. With such diversity in the disorder,

Damasio and his colleagues have observed that people who do not display the appropriate emotions before they decide, sometimes because of brain damage, also have an impaired ability to make good decisions.

The swelling can be so severe that it impairs blood flow and increases abdominal pressure, hindering the animal’s ability to breathe. Sometimes the liver and other organs will even rupture from the stress. Cruel and inhumane, it provides an excellent, if extreme, illustration of exactly what we’re doing to ourselves as a consequence of chronic sugar consumption: developing fat-filled livers and creating foie gras right inside of our own bodies.

Children who are seriously neglected during their early development also have smaller brains (fig. 7); their intelligence and linguistic and fine motor control are permanently impaired, and they are impulsive and hyperactive.

The worst period I ever went through at work,” a friend confides, “was when the company was restructuring and people were being ‘disappeared’ daily, followed by lying memos that they were leaving ‘for personal reasons.’ No one could focus while that fear was in the air. No real work got done.” Small wonder. The greater the anxiety we feel, the more impaired is the brain’s cognitive efficiency. In this zone of mental misery, distracting thoughts hijack our attention and squeeze our cognitive resources. Because high anxiety shrinks the space available to our attention, it undermines our very capacity to take in new information, let alone generate fresh ideas. Near-panic is the enemy of learning and creativity.

Spouse-abusers have a reactive aggressive personality that makes them more likely to lash out when provoked. Emotional words inordinately grab their attention. They are less able to inhibit the distracting emotional characteristics of stimuli, resulting in impaired cognitive performance. When presented with aggressive stimuli their brains overrespond at an emotional level and underrespond at a cognitive control level. Spouse-abusers are constitutionally different from other men.

It is interesting to note that the people who had a good relationship with the person who died often heal their grief much more easily than those whose relationship with the deceased was filled with turmoil, bitterness, or disappointment. The reason is that a positive relationship is associated with good memories, and remembering and reprocessing these memories helps in the healing process. When people who had a bad relationship think back on it, they have to relive the pain. In their mind, they are still trying to fix what was wrong, to heal the wound, but they can’t. In addition, the guilt they carry with them impairs the healing process. Donna is a case in point. Donna and her mother had had a stormy relationship, fighting constantly over things that seemed insignificant in and of themselves. Yet in spite of their problems, the year after her mother’s death was the hardest of Donna’s life. Her husband could not understand the force of her grief; all he had ever heard her do was complain that her mother was selfish and uninterested in her. What he failed to understand was that Donna had to grieve not only over her mother’s death, but also over the fact that now she would never have the mother-daughter bond she had always wanted. Death had ended all her hopes.

When rapid or binge drinking results in a blackout—a period of time for which the person cannot remember critical information or entire events—the hippocampal damage can be severe, impairing, in particular, a person’s ability to create new long-term memories.

Glucocorticoid hormones—anti-inflammatory steroid hormones, most notably cortisol—are secreted by the adrenal glands on signals from the hypothalamic-pituitary system in the brain. A diminished cortisol response by an impaired HPA axis would promote inflammation.

Then there were all the diseases one is vulnerable to in the woods — giardiasis, eastern equine encephalitis, Rocky Mountain spotted fever, Lyme disease, ehrlichiosis, schistosomiasis, brucellosis, and shigellosis, to offer but a sampling. Eastern equine encephalitis, caused by the prick of a mosquito, attacks the brain and central nervous system. If you’re lucky you can hope to spend the rest of your life propped in a chair with a bib around your neck, but generally it will kill you. There is no known cure. No less arresting is Lyme disease, which comes from the bite of a tiny deer tick. If undetected, it can lie dormant in the human body for years before erupting in a positive fiesta of maladies. This is a disease for the person who wants to experience it all. The symptoms include, but are not limited to, headaches, fatigue, fever, chills, shortness of breath, dizziness, shooting pains in the extremities, cardiac irregularities, facial paralysis, muscle spasms, severe mental impairment, loss of control of body functions, and — hardly surprising, really — chronic depression.

Italian researchers, for another example, have demonstrated that in elderly individuals suffering from mild cognitive impairment, those who consumed the highest level of flavonoids from cocoa and chocolate improved their insulin sensitivity and blood pressure significantly.

This isn't the first time I've used this, and the test subject showed no signs of impaired cognitive ability." "Who was the test subject?" asked Aurora. "I test everything out on myself before taking it into the field." She stared at him. "You zapped your own brain?" "And it didn't do me any harm apart from the dizziness and the vomiting spells and the weirdly persistent ringing in my ears. Also the blackouts and the mood swings and the creeping paranoia. Apart from that, zero side effects, if you don't count the numb fingertips. Which I don't.

It isn't like in books where the detective gets conked on the head, wakes up and keeps going another 48 hours straight. Exhaustion dulls the senses, impairs the brain and slows down the reflexes. Reaction time in business like this can be the difference between living and dying.

Damasio and his colleagues have observed that people who do not display the appropriate emotions before they decide, sometimes because of brain damage, also have an impaired ability to make good decisions. An inability to be guided by a “healthy fear” of bad consequences is a disastrous flaw.

When the brain is diseased, the functions that become pathological are the person’s emotional life, thought processes and behaviour. And this creates addiction’s central dilemma: if recovery is to occur, the brain, the impaired organ of decision making, needs to initiate its own healing process. An altered and dysfunctional brain must decide that it wants to overcome its own dysfunction: to revert to normal—or, perhaps, become normal for the very first time. The worse the addiction is, the greater the brain abnormality and the greater the biological obstacles to opting for health.

Brain development studies have shown that a traumatized brain is impaired in its ability to focus on language or verbal content. Instead, it tends to focus on processing nonverbal danger cues—body movements, facial expressions, and tone of voice—as it searches for information about danger and threat.

Addiction to softer drugs like alcohol or pot can be just as damaging but more insidious. The costs mount so slowly that they can be difficult to detect. That’s especially true of pot. If she’s using daily, don’t accept her protestations that marijuana has no deleterious effect on her. I don’t care how many cannabis evangelists she can rally to her cause, researchers tell a different story about heavy pot use. Heavy pot use lowers IQ (Meier et al. 2012); it damages memory (Solowij and Battisti 2008); it impairs decision-making (Tamm et al. 2013); it devastates motivation (Treadway et al. 2012; Smirnov and Kiyatkin 2008; Bloomfield et al. 2014); and it increases anxiety (Zvolensky et al. 2008). Finally, no matter what you might have heard, pot is addictive. In part, this is because it lowers the amount of available dopamine in the brain, necessitating its continued use to maintain normal levels (Hirvonen et al. 2011).

The repeated finding that people with happier, less troubled thought patterns can suffer more illness seems to defy common sense. The general belief is that positive emotions must be conducive to good health. While it is true that genuine joy and satisfaction enhance physical well-being, “positive” states of mind generated to tune out psychic discomfort lower resistance to illness. The brain governs and integrates the activities of all organs and systems of the body, simultaneously coordinating our interactions with the environment. This regulating function depends on the clear recognition of negative influences, danger signals and signs of internal distress. In children whose environment chronically conveys mixed messages, an impairment occurs in the developing apparatus of the brain. The brain’s capacity to evaluate the environment is diminished, including its ability to distinguish what is nourishing from what is toxic.

Not only could he share the memories, and control them, he could keep the link intact as their thoughts moved through time from the past to the present. The men of his clan enjoyed a richer, fuller ceremonial interrelationship than any other clan. But with the trained minds of the mog-urs, he could make the telepathic link from the beginning. Through him, all the mog-urs shared a union far closer and more satisfying than any physical one—it was a touching of spirits. The white liquid from Iza’s bowl that had heightened the perceptions and opened the minds of the magicians to The Mog-ur, had allowed his special ability to create a symbiosis with Ayla’s mind as well. The traumatic birth that damaged the brain of the disfigured man had impaired only a portion of his physical abilities, not the sensitive psychic overdevelopment that enabled his great power. But the crippled man was the ultimate end-product of his kind. Only in him had nature taken the course set for the Clan to its fullest extreme. There could be no further development without radical change, and their characteristics were no longer adaptable. Like the huge creature they venerated, and many others that shared their environment, they were incapable of surviving radical change. The race of men with social conscience enough to care for their weak and wounded, with spiritual awareness enough to bury their dead and venerate their great totem, the race of men with great brains but no frontal lobes, who made no great strides forward, who made almost no progress in nearly a hundred thousand years, was doomed to go the way of the woolly mammoth and the great cave bear. They didn’t know it, but their days on earth were numbered, they were doomed to extinction. In Creb, they had reached the end of their line. Ayla felt a sensation akin to the deep pulsing of a foreign bloodstream superimposed on her own. The powerful mind of the great magician was exploring her alien convolutions, trying to find a way to mesh. The fit was imperfect, but he found channels of similarity, and where none existed, he groped for alternatives and made connections where there were only tendencies. With startling clarity, she suddenly comprehended that it was he who had brought her out of the void; but more, he was keeping the other mog-urs, also linked with him, from knowing she was there. She could just barely sense his connection with them, but she could not sense them at all. They, too, knew he had made a connection with someone—or something—else, but never dreamed it was Ayla.

The major impairments of ADD — the distractibility, the hyperactivity and the poor impulse control — reflect, each in its particular way, a lack of self-regulation. Self-regulation implies that someone can direct attention where she chooses, can control impulses and can be consciously mindful and in charge of what her body is doing. Like time literacy, self-regulation is also a distinct task of development in human life, achieved gradually from young childhood through adolescence and adulthood. We are born with no capacity whatsoever to self-regulate emotion or action. For self-regulation to be possible, specific brain centers have to develop and grow connections with other important nerve centers, and chemical pathways need to be established. Attention deficit disorder is a prime illustration of how the adult continues to struggle with the unsolved problems of childhood. She is held back precisely where the child did not develop, hampered in those areas where the infant or toddler got stuck during the course of development.

Though diagnosis is unquestionably critical in treatment considerations for many severe conditions with a biological substrate (for example, schizophrenia, bipolar disorders, major affective disorders, temporal lobe epilepsy, drug toxicity, organic or brain disease from toxins, degenerative causes, or infectious agents), diagnosis is often counterproductive in the everyday psychotherapy of less severely impaired patients. Why? For one thing, psychotherapy consists of a gradual unfolding process wherein the therapist attempts to know the patient as fully as possible. A diagnosis limits vision; it diminishes ability to relate to the other as a person. Once we make a diagnosis, we tend to selectively inattend to aspects of the patient that do not fit into that particular diagnosis, and correspondingly overattend to subtle features that appear to confirm an initial diagnosis. What’s more, a diagnosis may act as a self-fulfilling prophecy. Relating to a patient as a “borderline” or a “hysteric” may serve to stimulate and perpetuate those very traits. Indeed, there is a long history of iatrogenic influence on the shape of clinical entities, including the current controversy about multiple-personality disorder and repressed memories of sexual abuse. And keep in mind, too, the low reliability of the DSM personality disorder category (the very patients often engaging in longer-term psychotherapy).

CONSENSUS PROPOSED CRITERIA FOR DEVELOPMENTAL TRAUMA DISORDER A. Exposure. The child or adolescent has experienced or witnessed multiple or prolonged adverse events over a period of at least one year beginning in childhood or early adolescence, including: A. 1. Direct experience or witnessing of repeated and severe episodes of interpersonal violence; and A. 2. Significant disruptions of protective caregiving as the result of repeated changes in primary caregiver; repeated separation from the primary caregiver; or exposure to severe and persistent emotional abuse B. Affective and Physiological Dysregulation. The child exhibits impaired normative developmental competencies related to arousal regulation, including at least two of the following: B. 1. Inability to modulate, tolerate, or recover from extreme affect states (e.g., fear, anger, shame), including prolonged and extreme tantrums, or immobilization B. 2. Disturbances in regulation in bodily functions (e.g. persistent disturbances in sleeping, eating, and elimination; over-reactivity or under-reactivity to touch and sounds; disorganization during routine transitions) B. 3. Diminished awareness/dissociation of sensations, emotions and bodily states B. 4. Impaired capacity to describe emotions or bodily states C. Attentional and Behavioral Dysregulation: The child exhibits impaired normative developmental competencies related to sustained attention, learning, or coping with stress, including at least three of the following: C. 1. Preoccupation with threat, or impaired capacity to perceive threat, including misreading of safety and danger cues C. 2. Impaired capacity for self-protection, including extreme risk-taking or thrill-seeking C. 3. Maladaptive attempts at self-soothing (e.g., rocking and other rhythmical movements, compulsive masturbation) C. 4. Habitual (intentional or automatic) or reactive self-harm C. 5. Inability to initiate or sustain goal-directed behavior D. Self and Relational Dysregulation. The child exhibits impaired normative developmental competencies in their sense of personal identity and involvement in relationships, including at least three of the following: D. 1. Intense preoccupation with safety of the caregiver or other loved ones (including precocious caregiving) or difficulty tolerating reunion with them after separation D. 2. Persistent negative sense of self, including self-loathing, helplessness, worthlessness, ineffectiveness, or defectiveness D. 3. Extreme and persistent distrust, defiance or lack of reciprocal behavior in close relationships with adults or peers D. 4. Reactive physical or verbal aggression toward peers, caregivers, or other adults D. 5. Inappropriate (excessive or promiscuous) attempts to get intimate contact (including but not limited to sexual or physical intimacy) or excessive reliance on peers or adults for safety and reassurance D. 6. Impaired capacity to regulate empathic arousal as evidenced by lack of empathy for, or intolerance of, expressions of distress of others, or excessive responsiveness to the distress of others E. Posttraumatic Spectrum Symptoms. The child exhibits at least one symptom in at least two of the three PTSD symptom clusters B, C, & D. F. Duration of disturbance (symptoms in DTD Criteria B, C, D, and E) at least 6 months. G. Functional Impairment. The disturbance causes clinically significant distress or impairment in at least two of the following areas of functioning: Scholastic Familial Peer Group Legal Health Vocational (for youth involved in, seeking or referred for employment, volunteer work or job training)

Rule #2. Drink plenty of water and don’t drink your calories. Your brain is 80 percent water. Anything that dehydrates it, such as too much caffeine or alcohol, decreases your thinking and impairs your judgment. Make sure you get plenty of water every day. To know you are drinking enough water for your brain, a good general rule is to consume half your weight

So you aren’t still in love with her?” I ask, eyebrows up, curious. “You’re over it? Over her? Sayonara, Daisy—” “Well—” His brows bend in the middle. BJ gives me a gentle but firm smile. “Magnolia.” “Oh—” I look at my fiancé. “Too much?” He gives me a tight smile. “You could try not talking for twenty seconds. See what happens.” I don’t do that. Instead I give Tiller an apologetic smile. “See, I was recently diagnosed with ADHD—” “Oh.” Tiller nods, not knowing what to say. “It impairs my prefrontal cortex—something about a neurotransmitter in the brain and then also lower levels of dopamine—which is so rude—don’t you think that’s so rude? Dopamine’s pretty nice—my doctor said it’s probably why I love shopping so much. And sex—

In preparing litigation on behalf of the children we were representing, it was clear that these shocking and senseless crimes couldn't be evaluated honestly without understanding the lives these children had been forced to endure. And in banning the death penalty for juveniles, the Supreme Court had paid great attention to the emerging body of medical research about adolescent development and brain science and its relevance to juvenile crime and culpability. Contemporary neurological, psychological, and sociological evidence has established that children are impaired by immature judgment, an underdeveloped capacity for self-regulation and responsibility, vulnerability to negative influences and outside pressures, and a lack of control over their own impulses and their environment.

What they found was striking: higher levels of the inactive form of IRS-1 (signifying impaired insulin signaling in the brain) predicted Alzheimer’s disease development in patients with 100 percent accuracy.20 Even more breathtaking, the difference in these blood markers was evident ten years prior to the emergence of symptoms. This suggests that maintaining the brain’s insulin sensitivity throughout life may be a major step toward preventing the disease.

When someone is tired, their judgment can be impaired. When they are dragging, it is hard for them to float above a problem and picture themselves and the problem in another place and time, so I gave them another directive: sleep. When you sleep, your brain is actually engaged in the neurochemical process of judgment. It is mapping connections and finding meaning among all the data you took in during the day. Tired people tend not to have the best judgment.

Some parents resist the idea of ADD for fear of seeing their children labeled and categorized. They do not like the idea of pinning a medical diagnosis on a child who, except in certain areas of functioning, seems quite well. Such fears are not baseless. Too often ADD seems no more than a judgment that characterizes a child as a problem student, incapable of normal activity. How people use language is quite revealing. People commonly say that this adult or that child “is ADD.” That, indeed, is labeling, identifying the whole person with an area of weakness or impairment. No one is ADD, and no one should be defined or categorized in terms of it or any other particular problem. Recognizing a child’s ADD should be simply a way of understanding that helping him calls for some knowledgeable and creative approaches, not a judgment that there is anything fundamentally or irretrievably wrong with him. This recognition should enable us to support the child in fullfilling his potential, not to further limit him. That even open-minded people may have difficulty coming to terms with this diagnosis is only to be expected. Our usual mode of thinking about illness (or anything else, for that matter) is not comfortable with ambiguity. A patient either has pneumonia or does not; she either has some illness affecting the mind or does not. There is a popular discomfort with any condition of the mind perceived as “abnormal.” But what if illness is not a separate category, if there is no line of distinction between the “healthy” and the “nonheaithy,” if the “abnormality” is just a greater concentration in an individual of disturbed brain processes found in everyone? Then perhaps there are no fixed, immutable brain disorders, and we could all be vulnerable to mental breakdowns or malfunctions under the pressure of stressful circumstances. We could all go crazy. Maybe we already have.

People with a right parietal lobe injury, for example, will commonly suffer from a syndrome called spatial hemi-neglect. Depending on the size and location of the lesion, patients with hemi-neglect may behave as if part or all of the left side of their world, which may include the left side of their body, does not exist! This could include not eating off the left side of their plate, not shaving or putting makeup on the left side of their face, not drawing the left side of a clock, not reading the left pages of a book, and not acknowledging anything or anyone in the left half of the room. Some will deny that their left arm and leg are theirs and will not use them when trying to get out of bed, even though they are not paralyzed. Some patients will even neglect the left side of space in their imagination and memories.3 That the deficits vary according to the size and location of the lesion suggests that damage that disrupts specific neural circuits results in impairments in different component processes.

I figured scraps were better than nothing at all. I failed to realize that the same thing that distinguishes addiction from passionate interest also divides unhealthy love from that which is the highest experience of humanity. That is, love is real when it expands and enhances your life—and troubling and problematic when it contracts or impairs it. Whether you love a person, a drug, or an intellectual interest, if it is spurring creativity, connection, and kindness, it’s not an addiction—but if it’s making you isolated, dull, and mean,

Opioid circuits and dopamine pathways are important components of what has been called the limbic system, or the emotional brain. The circuits of the limbic system process emotions like love, joy, pleasure, pain, anger and fear. For all their complexities, emotions exist for a very basic purpose: to initiate and maintain activities necessary for survival. In a nutshell, they modulate two drives that are absolutely essential to animal life, including human life: attachment and aversion. We always want to move toward something that is positive, inviting and nurturing, and to repel or withdraw from something threatening, distasteful or toxic. These attachment and aversion emotions are evoked by both physical and psychological stimuli, and when properly developed, our emotional brain is an unerring, reliable guide to life. It facilitates self-protection and also makes possible love, compassion and healthy social interaction. When impaired or confused, as it often is in the complex and stressed circumstances prevailing in our “civilized” society, the emotional brain leads us to nothing but trouble. Addiction is one of its chief dysfunctions.

Experiments in limiting reproduction to the undesirable classes were unconsciously made in mediæval Europe under the guidance of the church. After the fall of Rome social conditions were such that all those who loved a studious and quiet life were compelled to seek refuge from the violence of the times in monastic institutions and upon such the church imposed the obligation of celibacy and thus deprived the world of offspring from these desirable classes. In the Middle Ages, through persecution resulting in actual death, life imprisonment and banishment, the free thinking, progressive and intellectual elements were persistently eliminated over large areas, leaving the perpetuation of the race to be carried on by the brutal, the servile and the stupid. It is now impossible to say to what extent the Roman Church by these methods has impaired the brain capacity of Europe, but in Spain alone, for a period of over three centuries from the years 1471 to 1781, the Inquisition condemned to the stake or imprisonment an average of 1,000 persons annually. During these three centuries no less than 32,000 were burned alive and 291,000 were condemned to various terms of imprisonment and other penalties and 17,000 persons were burned in effigy, representing men who had died in prison or had fled the country. No better method of eliminating the genius producing strains of a nation could be devised and if such were its purpose the result was eminently satisfactory, as is demonstrated by the superstitious and unintelligent Spaniard of to-day. A similar elimination of brains and ability took place in northern Italy, in France and in the Low Countries, where hundreds of thousands of Huguenots were murdered or driven into exile.

Perhaps the most exasperating cliche is about children being forced to memorize, not think. But memorization is not an abomination in itself, though the mnemic pressure on our species has dropped. Memorization is, de facto, exercise for the mind. Neuroscience shows an active hippocampus stimulates cerebral activity. We have often observed how the most profound and creative pupils are those who know the most things, though their usefulness is not always apparent. No question is more insinuating stupid than 'What good will it do to me?' In certain teaching contexts, it is not wrong to ask pupils to memorize. While it is not the only goal the idea that memorizing is useless since information is available online is also wrong and falsely self-obvious. It denotes a misunderstanding of how our mind works. Our brains are not computers, our memory can't be replaced by external HDDs. Each piece of info we memorize is integrated, albeit minimally, as living memory is active, while digital memory is passive. Strange as some may find it, memorizing can stimulate thinking as few other things can. What impairs thinking is the lack of the habit to reflect, the custom of stopping our mind's flow to go back to what we've learned.

So people feel tired, wired, and stressed at the same time. In one group of patients with rapid cycling bipolar disorder, more than 50 percent had hypothyroidism. Experts conservatively estimate that one-third of all depressions are directly related to thyroid imbalance. More than 80 percent of people with low-grade hypothyroidism have impaired memory function. Low thyroid is associated with a host of symptoms and problems, such as: Feeling cold when others are hot Weight gain Constipation Fatigue High cholesterol High blood pressure Dry, thinning, or losing hair, especially the eyebrows, where the outer third are often missing

There's a psychologist called Mary & Diamond who at Brooklyn in California, in the 80s studied rats. And they took rats at different ages. Newborns, some of whom they deliberately brain damaged, adult, middle-aged, elderly rats. And they exposed these rats to different levels of environmental stimulation, better food, more playmates, toys to play with and so on. They found out a couple of months later that the rats, at any age, including the brain-damaged rats, who had the better stimulation, they were smarter. But in the autopsy then they also found that in the front part of their brain they had larger nerve-cells with more connections with other nerve-cells and richer blood supply. In other words that environmental stimulation actually caused a change in the state of the brain, even in the older rats. And that's called neuroplasticity. The capacity of the brain to develop new circuits. So whether it comes to ADHD, addiction, depression or other childhood disorders or any other issue with adults as well, if we recognize them not as ingrained, genetically-determined diseases, but as problems of development, then the question becomes very different. Then the question becomes not just "how do we treat the symptoms?" (and addiction itself is a symptom, depression is a symptom), but "how do we help people develop out of these conditions?" In other words, it is not a medical question, purely, but a developmental question. And development always requires the right environment. Now, if you're a gardener you know that. If you are growing plants in your backyard and you want them to grow into healthy, functioning beings, botanical beings, you want to provide them with the right nurturing, the right nutrition, minerals, water, sunlight and so on. So the real question is how do we provide the conditions for further development for people whose development was impaired in the first place? Now we know how to do that. We are just not doing it.

The idea that hyperreactivity and hyporeactivity are two variations on a theme might even have implications for theory of mind. The “Intense World” paper proposed that if the amygdala, which is associated with emotional responses, including fear, is affected by sensory overload, then certain responses that look antisocial actually aren’t. “Impaired social interactions and withdrawal may not be the result of a lack of compassion, incapability to put oneself into someone else’s position or lack of emotionality, but quite to the contrary a result of an intensely if not painfully aversively perceived environment.” Behavior that looks antisocial to an outsider might actually be an expression of fear.

The right and left hemispheres of our brain show differences in their gross anatomy, many of which are also found in the brains of other animals. In humans, the left hemisphere generally makes a unique contribution to language and to the performance of complex movements. Consequently, damage on this side tends to be accompanied by aphasia (impairment of spoken or written language) and apraxia (impairment of coordinated movement). People usually show a right-ear (left-hemisphere) advantage for words, digits, nonsense syllables, Morse code, difficult rhythms, and the ordering of temporal information, whereas they show a left-ear (right-hemisphere) advantage for melodies, musical chords, environmental sounds, and tones of voice.

This tragic sequence helps explain the fearful loss of cognition in coronary artery bypass patients.3 But neuroradiologists also report that using magnetic resonance imaging, they can detect little white spots in the brains of Americans starting at about age fifty. These spots represent small, asymptomatic strokes (see Figures 18 and 19 in insert). The brain has so much reserve capacity that at first these tiny strokes cause no trouble. But, if they continue, they begin to cause memory loss and, ultimately, crippling dementia. In fact, one recently reported study found that the presence of these “silent brain infarcts” more than doubles the risk of dementia.4 We now believe, in fact, that at least half of all senile mental impairment is caused by vascular injury to the brain.

Reproductive hormones aren’t the only hormones that affect how you look and feel and think. Among the most influential are the hormones produced by your thyroid gland. Too little thyroid, and you feel like a slug. Hypothyroidism makes you feel like you just want to lie on the couch all day with a bag of chips. Everything works slower, including your heart, your bowels, and your brain. When we perform SPECT scans of people with hypothyroidism, we see decreased brain activity. Many other studies confirm that overall low brain function in hypothyroidism leads to depression, cognitive impairment, anxiety, and feelings of being in a mental fog. The thyroid gland drives the production of many neurotransmitters that run the brain, such as serotonin, dopamine, adrenaline, and noradrenaline. A

Neuroimaging studies show the PFC reining in more emotional brain regions in the name of doing (or thinking) the right thing. Stick a volunteer in a brain scanner and flash up pictures of faces. And in a depressing, well-replicated finding, flash up the face of someone of another race and in about 75 percent of subjects, there is activation of the amygdala, the brain region central to fear, anxiety, and aggression.[*] In under a tenth of a second.[*] And then the PFC does the harder thing. In most of those subjects, a few seconds after the amygdala activates, the PFC kicks in, turning off the amygdala. It’s a delayed frontocortical voice—“Don’t think that way. That’s not who I am.” And who are the folks in which the PFC doesn’t muzzle the amygdala? People whose racism is avowedly, unapologetically explicit—“That is who I am.”[13] In another experimental paradigm, a subject in a brain scanner plays an online game with two other people—each is represented by a symbol on the screen, forming a triangle. They toss a virtual ball around—the subject presses one of two buttons, determining which of the two symbols the ball is tossed to; the other two toss it to each other, toss it back to the subject. This goes on for a while, everyone having a fine time, and then, oh no, the other two people stop tossing the ball to the subject. It’s the middle-school nightmare: “They know I’m a dork.” The amygdala rapidly activates, along with the insular cortex, a region associated with disgust and distress. And then, after a delay, the PFC inhibits these other regions—“Get this in perspective; this is just a stupid game.” In a subset of individuals, however, the PFC doesn’t activate as much, and the amygdala and insular cortex just keep going, as the subject feels more subjective distress. Who are these impaired individuals? Teenagers—the PFC isn’t up to the task yet of dismissing social ostracism as meaningless. There you have it.[*]

A dramatic illustration of how environment shapes personality is the story of the Gilmore family. On January 17, 1978, in Utah, the convicted double murderer Gary Gilmore was executed by firing squad, his unyielding refusal to appeal his death sentence having gained him a measure of international notoriety. The shattering story of his childhood, blighted by family violence, alcoholism and spite was chronicled later by his brother Mikal Gilmore in the memoir Shot in the Heart. Mikal, the youngest of four boys, was born when Gary was eleven years old. If children reared in the same family shared the same environment, the differences between siblings would have to be due to genetic inheritance. In the case of the Gilmores, it is easy to see why Mikal, born at a time when the family was enjoying a period of relative stability, would feel he had been brought up in a different world, why the misery of his childhood, as he put it, had been so radically different from the misery of his brothers’ childhood. Even without such vast chasms in experience, the environment of siblings is never the same. Environment has far greater impact on the structures and circuits of the human brain than was realized even a decade ago. It is what shapes the inherited genetic material. I believe it to be the decisive factor in determining whether the impairments of ADD will or will not appear in a child. Many variables will influence the particular environment a child experiences. Birth order, for one, automatically places siblings in dissimilar situations. The older sibling has to suffer the pain of seeing parental love and attention directed toward an intruder. The younger sibling may need to learn survival in an environment that harbors a stronger, potentially hostile rival, and never comes to know either the special status or the burden of being an only child. The full weight of unconscious parental expectations is far more likely to fall on the firstborn. Historical studies of birth order have established it as an important influence on the shaping of the personality, comparable with sex.

So how much sleep is enough? Generally, sleep specialists recommend that adults get between seven and nine hours of sleep per night, though there is no perfect number for the amount of sleep you may need personally. Doctors and scientists agree on one thing overall, however: Getting too little sleep—five hours a night or less for most people—results in a wide range of cognitive and physical impairments. Neurons in the brain can’t consolidate the information you’ve taken in, so you don’t store memories and you lose the ability to use this information. Add to this the compromised motor control, lack of focus, and difficulty with decision making and problem solving that come with sleep deprivation, and you may think twice about catching The Tonight Show and choose to turn in earlier than usual. Stress When your brain is bombarded with stimuli that trigger anxiety, you experience stress—a series of biological and chemical processes throughout your body that initiates a fight-or-flight response. In a nutshell, here’s what happens: Your sympathetic nervous system, commanded by the hypothalamus—a small area at your brain’s base—releases stress hormones that ready you to deal with whatever threat has emerged. First, your adrenal glands (on top of your kidneys) release adrenaline, which causes increases in breathing rate, heart rate, and blood pressure. These glands also release cortisol, which increases

What is ADHD, anyway? For those still wondering what ADHD is, here’s the briefest summary I can muster: ADHD shows up in two areas of our brain function: working memory and executive functioning.[7] Working memory allows us to hold more than one thing in our brains at once. If you’ve ever run up the stairs, only to find yourself standing in your bedroom wondering what you came for, you’ve experienced a failure of working memory. Again, everyone experiences this from time to time. People with ADHD experience it nonstop, to the point where it impairs our ability to function normally. Working memory holds onto information until we’re able to use it.[8] In addition to forgetting why we opened the refrigerator, having a leaky working memory means we lose information before our brains can move it to long-term storage. We forget a lot of things before we have a chance to act on them or write them down. Our executive functions, on the other hand, give us the power to delay gratification, strategize, plan ahead, and identify and respond to others’ feelings.[9] That’s some list, isn’t it? In the same way a diabetic’s body cannot effectively regulate insulin, imagine your brain being unable to control these behaviors. This explains why ADHDers’ behavior so often defies norms and expectations for their age group — and this persists throughout their lifespan, not just grade school. ADHD isn’t a gift. It isn’t a sign of creativity or intelligence, nor is it a simple character flaw. And it’s more than eccentric distractibility, forgetfulness, and impulsivity. ADHD is a far-reaching disorder that touches every aspect of our lives. If we leave it unchecked, it will generate chaos at home, at work, and everywhere in between.

Interactions with the world program our physiological and psychological development. Emotional contact is as important as physical contact. The two are quite analogous, as we recognize when we speak of the emotional experience of feeling touched. Our sensory organs and brains provide the interface through which relationships shape our evolution from infancy to adulthood. Social-emotional interactions decisively influence the development of the human brain. From the moment of birth, they regulate the tone, activity and development of the psychoneuroimmunoendocrine (PNI) super-system. Our characteristic modes of handling psychic and physical stress are set in our earliest years. Neuroscientists at Harvard University studied the cortisol levels of orphans who were raised in the dreadfully neglected child-care institutions established in Romania during the Ceausescu regime. In these facilities the caregiver/child ratio was one to twenty. Except for the rudiments of care, the children were seldom physically picked up or touched. They displayed the self-hugging motions and depressed demeanour typical of abandoned young, human or primate. On saliva tests, their cortisol levels were abnormal, indicating that their hypothalamic-pituitary-adrenal axes were already impaired. As we have seen, disruptions of the HPA axis have been noted in autoimmune disease, cancer and other conditions. It is intuitively easy to understand why abuse, trauma or extreme neglect in childhood would have negative consequences. But why do many people develop stress-related illness without having been abused or traumatized? These persons suffer not because something negative was inflicted on them but because something positive was withheld.

One form of insecurity of attachment, called "disorganized/disoriented", has been associated with marked impairments in the emotional, social, and cognitive domains, and a predisposition toward a clinical condition known as dissociation in which the capacity to function in an organized, coherent manner is at times impaired. Studies have also found that youths with a history of disorganized attachments are at great risk of expressing hostility with their peers and have the potential for interpersonal violence as they mature (Lyons-Ruth & Jacobwitz, 1999; Carlson, 1998). This disorganized form of attachment has been proposed to be associated with the caregiver's frightened, frightening, or disoriented behavior with the child. Such experiences create a state of alarm in the child. The parents of these children often have an autobiographical narrative finding, as revealed in the Adult Attachment Interview, of unresolved trauma or grief that appears as a disorientation in their narrative account of their childhoods. Such linguistic disorientation occurs during the discussion of loss or threat from childhood experiences. Lack of resolution appears to be associated with parental behaviors that are incompatible with an organized adaptation on the part of the child. Lack of resolution of trauma or grief in a parent can lead to parental behaviors that create "paradoxical", unsolvable, and problematic situations for the child. The attachment figure is intended to be the source of protection, soothing, connections, and joy. Instead, the experience of the child who develops a disorganized attachment is such that the caregiver is actually the source of terror and fear, of "fright without solution", and so the child cannot turn to the attachment figure to be soothed (Main & Hesse, 1990). There is not organized adaptation and the child's response to this unsolvable problem is disorganization (see Hesse et al., this volume).

The effectiveness of a doctrine does not come from its meaning but from its certitude. No doctrine however profound and sublime will be effective unless it is presented as the embodiment of the one and only truth. It must be the one word from which all things are and all things speak. Crude absurdities, trivial nonsense and sublime truths are equally potent in readying people for self-sacrifice if they are accepted as the sole, eternal truth. It is obvious, therefore, that in order to be effective a doctrine must not be understood, but has rather to be believed in. We can be absolutely certain only about things we do not understand. A doctrine that is understood is shorn of its strength. Once we understand a thing, it is as if it had originated in us. And, clearly, those who are asked to renounce the self and sacrifice it cannot see eternal certitude in anything which originates in that self. The fact that they understand a thing fully impairs its validity and certitude in their eyes. The devout are always urged to seek the absolute truth with their hearts and not their minds. "It is the heart which is conscious of God, not the reason." Rudolph Hess, when swearing in the entire Nazi party in 1934, exhorted his hearers: "Do not seek Adolph Hitler with your brains; all of you will find him with the strength of your hearts." When a movement begins to rationalize its doctrine and make it intelligible, it is a sign that its dynamic span is over; that it is primarily interested in stability. For, as will be shown later (Section 106), the stability of a regime requires the allegiance of the intellectuals, and it is to win them rather than to foster self-sacrifice in the masses that a doctrine is made intelligible. If a doctrine is not unintelligible, it has to be vague; and if neither unintelligible nor vague, it has to be unverifiable. One has to get to heaven or the distant future to determine the truth of an effective doctrine. When some part of a doctrine is relatively simple, there is a tendency among the faithful to complicate and obscure it. Simple words are made pregnant with meaning and made to look like symbols in a secret message. There is thus an illiterate air about the most literate true believer. He seems to use words as if he were ignorant of their true meaning. Hence, too, his taste for quibbling, hair-splitting and scholastic tortuousness.

Washington University found that adding a single extra gene dramatically boosted a mouse’s memory and ability. These “smart mice” could navigate mazes faster, remember events better, and outperform other mice in a wide variety of tests. They were dubbed “Doogie mice,” after the precocious character on the TV show Doogie Howser, M.D. Dr. Tsien began by analyzing the gene NR2B, which acts like a switch controlling the brain’s ability to associate one event with another. (Scientists know this because when the gene is silenced or rendered inactive, mice lose this ability.) All learning depends on NR2B, because it controls the communication between memory cells of the hippocampus. First Dr. Tsien created a strain of mice that lacked NR2B, and they showed impaired memory and learning disabilities. Then he created a strain of mice that had more copies of NR2B than normal, and found that the new mice had superior mental capabilities. Placed in a shallow pan of water and forced to swim, normal mice would swim randomly about. They had forgotten from just a few days before that there was a hidden underwater platform. The smart mice, however, went straight to the hidden platform on the first try. Since then, researchers have been able to confirm these results in other labs and create even smarter strains of mice. In 2009, Dr. Tsien published a paper announcing yet another strain of smart mice, dubbed “Hobbie-J” (named after a character in Chinese cartoons). Hobbie-J was able to remember novel facts (such as the location of toys) three times longer than the genetically modified strain of mouse previously thought to be the smartest. “This adds to the notion that NR2B is a universal switch for memory formation,” remarked Dr. Tsien. “It’s like taking Michael Jordon and making him a super Michael Jordan,” said graduate student Deheng Wang. There are limits, however, even to this new mice strain. When these mice were given a choice to take a left or right turn to get a chocolate reward, Hobbie-J was able to remember the correct path for much longer than the normal mice, but after five minutes he, too, forgot. “We can never turn it into a mathematician. They are rats, after all,” says Dr. Tsien. It should also be pointed out that some of the strains of smart mice were exceptionally timid compared to normal mice. Some suspect that, if your memory becomes too great, you also remember all the failures and hurts as well, perhaps making you hesitant. So there is also a potential downside to remembering too much.

And by the end of March one of them had already begun his journey. Twenty-two years old, an A.B. and LL.B. of Harvard, Francis Parkman was back from a winter trip to scenes in Pennsylvania and Ohio that would figure in his book and now he started with his cousin, Quincy Adams Shaw, for St. Louis. He was prepared to find it quite as alien to Beacon Hill as the Dakota lands beyond it, whither he was going. He was already an author (a poet and romancer), had already designed the great edifice his books were to build, and already suffered from the mysterious, composite illness that was to make his life a long torture. He hoped, in fact, that a summer on the prairies might relieve or even cure the malady that had impaired his eyes and, he feared, his heart and brain as well. He had done his best to cure it by systematic exercise, hard living in the White Mountains, and a regimen self-imposed in the code of his Puritan ancestors which would excuse no weakness. But more specifically Parkman was going west to study the Indians. He intended to write the history of the conflict between imperial Britain and imperial France, which was in great part a story of Indians. The Conspiracy of Pontiac had already taken shape in his mind; beyond it stretched out the aisles and transepts of what remains the most considerable achievement by an American historian. So he needed to see some uncorrupted Indians in their native state. It was Parkman’s fortune to witness and take part in one of the greatest national experiences, at the moment and site of its occurrence. It is our misfortune that he did not understand the smallest part of it. No other historian, not even Xenophon, has ever had so magnificent an opportunity: Parkman did not even know that it was there, and if his trip to the prairies produced one of the exuberant masterpieces of American literature, it ought instead to have produced a key work of American history. But the other half of his inheritance forbade. It was the Puritan virtues that held him to the ideal of labor and achievement and kept him faithful to his goal in spite of suffering all but unparalleled in literary history. And likewise it was the narrowness, prejudice, and mere snobbery of the Brahmins that insulated him from the coarse, crude folk who were the movement he traveled with, turned him shuddering away from them to rejoice in the ineffabilities of Beacon Hill, and denied our culture a study of the American empire at the moment of its birth. Much may rightly be regretted, therefore. But set it down also that, though the Brahmin was indifferent to Manifest Destiny, the Puritan took with him a quiet valor which has not been outmatched among literary folk or in the history of the West.

To their surprise, they found that dopamine actively regulates both the formation and the forgetting of new memories. In the process of creating new memories, the dCA1 receptor was activated. By contrast, forgetting was initiated by the activation of the DAMB receptor. Previously, it was thought that forgetting might be simply the degradation of memories with time, which happens passively by itself. This new study shows that forgetting is an active process, requiring intervention by dopamine. To prove their point, they showed that by interfering with the action of the dCA1 and DAMB receptors, they could, at will, increase or decrease the ability of fruit flies to remember and forget. A mutation in the dCA1 receptor, for example, impaired the ability of the fruit flies to remember. A mutation in the DAMB receptor decreased their ability to forget. The researchers speculate that this effect, in turn, may be partially responsible for savants’ skills. Perhaps there is a deficiency in their ability to forget. One of the graduate students involved in the study, Jacob Berry, says, “Savants have a high capacity for memory. But maybe it isn’t memory that gives them this capacity; maybe they have a bad forgetting mechanism. This might also be the strategy for developing drugs to promote cognition and memory—what about drugs that inhibit forgetting as a cognitive enhancers?” Assuming that this result holds up in human experiments as well, it could encourage scientists to develop new drugs and neurotransmitters that are able to dampen the forgetting process. One might thus be able to selectively turn on photographic memories when needed by neutralizing the forgetting process. In this way, we wouldn’t have the continuous overflow of extraneous, useless information, which hinders the thinking of people with savant syndrome. What is also exciting is the possibility that the BRAIN project, which is being championed by the Obama administration, might be able to identify the specific pathways involved with acquired savant syndrome. Transcranial magnetic fields are still too crude to pin down the handful of neurons that may be involved. But using nanoprobes and the latest in scanning technologies, the BRAIN project might be able to isolate the precise neural pathways that make possible photographic memory and incredible computational, artistic, and musical skills. Billions of research dollars will be channeled into identifying the specific neural pathways involved with mental disease and other afflictions of the brain, and the secret of savant skills may be revealed in the process. Then it might be possible to take normal individuals and make savants out of them. This has happened many times in the past because of random accidents. In the future, this may become a precise medical process.

It’s a perspective on story that may also shed light on why you and I and everyone else spend a couple of hours each day concocting tales that we rarely remember and more rarely share. By day I mean night, and the tales are those we produce during REM sleep. Well over a century since Freud’s The Interpretation of Dreams, there is still no consensus on why we dream. I read Freud’s book for a junior-year high school class called Hygiene (yes, that’s really what it was called), a somewhat bizarre requirement taught by the school’s gym teachers and sports coaches that focused on first aid and common standards of cleanliness. Lacking material to fill an entire semester, the class was padded by mandatory student presentations on topics deemed loosely relevant. I chose sleep and dreams and probably took it all too seriously, reading Freud and spending after-school hours combing through research literature. The wow moment for me, and for the class too, was the work of Michel Jouvet, who in the late 1950s explored the dream world of cats.32 By impairing part of the cat brain (the locus coeruleus, if you like that sort of thing), Jouvet removed a neural block that ordinarily prevents dream thoughts from stimulating bodily action, resulting in sleeping cats who crouched and arched and hissed and pawed, presumably reacting to imaginary predators and prey. If you didn’t know the animals were asleep, you might think they were practicing a feline kata. More recently, studies on rats using more refined neurological probes have shown that their brain patterns when dreaming so closely match those recorded when awake and learning a new maze that researchers can track the progress of the dreaming rat mind as it retraces its earlier steps.33 When cats and rats dream it surely seems they’re rehearsing behaviors relevant to survival. Our common ancestor with cats and rodents lived some seventy or eighty million years ago, so extrapolating a speculative conclusion across species separated by tens of thousands of millennia comes with ample warning labels. But one can imagine that our language-infused minds may produce dreams for a similar purpose: to provide cognitive and emotional workouts that enhance knowledge and exercise intuition—nocturnal sessions on the flight simulator of story. Perhaps that is why in a typical life span we each spend a solid seven years with eyes closed, body mostly paralyzed, consuming our self-authored tales.34 Intrinsically, though, storytelling is not a solitary medium. Storytelling is our most powerful means for inhabiting other minds. And as a deeply social species, the ability to momentarily move into the mind of another may have been essential to our survival and our dominance. This offers a related design rationale for coding story into the human behavioral repertoire—for identifying, that is, the adaptive utility of our storytelling instinct.

Are you interested in medical marijuana but have no idea what it is? In recent years, there is a growing cry for the legalization of cannabis because of its proven health benefits. Read on as we try to look into the basics of the drug, what it really does to the human body, and how it can benefit you. Keep in mind that medical marijuana is not for everyone, so it’s important that you know how you’re going to be using it before you actually use it. What is Marijuana? Most likely, everyone has heard of marijuana and know what it is. However, many people hold misconceptions of marijuana because of inaccurate news and reporting, which has led to the drug being demonized—even when numerous studies have proven the health benefits of medical marijuana when it is used in moderation. (Even though yes, weed is also used as a recreational drug.) First and foremost, medical marijuana is a plant. The drug that we know of is made of its shredded leaves and flowers of the cannabis sativa or indica plant. Whatever its strain or form, all types of cannabis alter the mind and have some degree of psychoactivity. The plant is made of chemicals, with tetrahydrocannabinol (THC) being the most powerful and causing the biggest impact on the brain. How is Medical Marijuana Used? There are several ways medical weed is used, depending on the user’s need, convenience and preference. The most common ways are in joint form, and also using bongs and vaporizers. But with its growing legalization, we’re seeing numerous forms of cannabis consumption methods being introduced (like oils, edibles, drinks and many more). ● Joint – Loose marijuana leaves are rolled into a cigarette. Sometimes, it’s mixed with tobacco to cut the intensity of the cannabis. ● Bong – This is a large water pipe that heats weed into smoke, which the user then inhales. ● Vaporizer – Working like small bongs, this is a small gadget that makes it easier to bring and use weed practically anywhere. What’s Some Common Medical Marijuana Lingo? We hear numerous terms from people when it comes to describing medical marijuana, and this list continually grows. An example of this is the growing number of marijuana nicknames which include pot, grass, reefer, Mary Jane, dope, skunk, ganja, boom, chronic and herb among many others. Below are some common marijuana terms and what they really mean. ● Bong – Water pipe that allows for weed to be inhaled ● Blunt – Hollowed-out cigar with the tobacco replaced with weed ● Hash – Mix of medical weed and tobacco ● Joint – Rolled cigarette-like way to consume medical cannabis How Does It Feel to be High? When consumed in moderation, weed’s common effects include a heightened sense of euphoria and well-being. You’ll most likely talk and laugh more. At its height, the high creates a feeling of pensive dreaminess that wears off and becomes sleepiness. In a group setting, there are commonly feelings of exaggerated physical and emotional sensitivity as well as strong feelings of camaraderie. Medical marijuana also has a direct impact on a person’s speech patterns, which will get slower. There will be an impairment in your ability to carry out conversations. Cannabis also affects short-term memory. The usual high that one gets from cannabis can last for about two hours; when you overindulge, it can last for up to 12 hours. Is Using Medical Marijuana Safe? Medical cannabis is scientifically proven to be safer compared to alcohol or nicotine. Marijuana is slowly being legalized around the world because of its numerous health benefits, particularly among people suffering from mental illness like depression, anxiety and stress. It also has physical benefits, like helping in managing pain and the treatment of glaucoma and cancer.

of stimulating reward pathways in the brain, such as drugs, sex, aggression, and intimidating others, could become relatively more attractive and less constrained by concern about violating trusting relationships. The ability to modify behavior based on negative experiences may be impaired.30 Hard-core drug addicts, whose lives invariably began under conditions of severe stress, are all too readily triggered into a stress reaction. Not only does the stress response easily overwhelm the addict’s already-challenged capacity for rational thought when emotionally aroused, but the hormones of stress also “cross-sensitize” with addictive substances. The more one is present, the more the other is craved. Addiction is a deeply ingrained response to stress, an attempt to cope with it through self-soothing. Maladaptive in the long term, it is highly effective in the short term. Predictably, stress is a major cause of continued drug dependence. It increases opiate craving and use, enhances the reward efficacy of drugs, and provokes relapse to drug seeking and drug taking.31 “Exposure to stress is the most powerful and reliable experimental manipulation used to induce reinstatement of alcohol or drug use,” one team of researchers reports.32 “Stressful experiences,” another research group points out, “increase the vulnerability of the individual to either develop drug self-administration or relapse.”33

Suicidal thought is a symptom of illness, of something else gone wrong. Most suicides are not impulsive, spur -of-the-moment decisions at all. Instead, most of these deaths are the result of a person losing a long and painful battle against their own impaired thinking. A suicidal person is someone who is unable to tolerate their suffering any longer. Even if she does not really want to die, she knows death will end that suffering once and for all.

Without negative ions, supply channels in the cells constrict, nutrient distribution and cell activity is impaired, and the body begins to send out pain signals. Pain is felt when the brain receives too many electric signals from positive ions.

be that excessive stress and hormonal secretion during a trauma directly impair the functioning of parts of the brain necessary for autobiographical memories to be stored. After the trauma, recollection of those details encoded in only nonverbal form will likely evoke distressful emotions that can be deeply disturbing.

People who've suffered that degree of trauma are often irreversibly impaired ... I had to accept the fact that there'd be some residual damage. If babies are starved and fed later, their bones will always show the traces of the lack of food. The same is true of severe abuse. The brain will adapt in strange ways, but it won't ever be fully normal, whatever that means.

Dopamine and constant stimulation can impair your ability to think long term Studies have shown that one of the best predictors of success is the ability to think long term. People who repeatedly focus on where they want to be in the future, make better decisions in the present. They tend to eat healthier food, be more productive at work and save and invest more money than others.

When we learn about threats as children, and they are accompanied by strong emotions such as fear, they can remain embedded in the neural circuits of the hippocampus for life. Neuroscientists call these “deep emotional learnings.” Like the old posters, they may have no use in the present. They may even be triggering us to react to threats that are entirely imaginary. Yet once learned, and reinforced by conditioned behavior, they are hard to change. Like the dusty posters in the pubs, they may hang around long after they’ve outlived their usefulness. When the hippocampus isn’t sure what to make of a piece of information, it refers it to the brain’s prefrontal cortex (PFC). That’s the brain’s executive center, the seat of discrimination and knowledge. It takes incoming information from the hippocampus and determines whether the apparent threat is real. For instance, you hear a loud bang and are immediately alarmed. “Gunfire?” wonders the hippocampus. “No,” the PFC tells it. “That was a car backfiring.” The reassured hippocampus then does not pass the alarm to the amygdala. Or perhaps the PFC says, “That group of young men hanging out in the parking lot looks suspicious,” and the hippocampus then signals the amygdala, which puts the body on Code Red. Using that path from the emotional center of the brain to the executive center is crucial to regulating our emotions. Because it involves a feedback loop with information going first to the PFC and then back to the hippocampus from the PFC, it’s called the long path: hippocampus > PFC > hippocampus > amygdala > FFF. The long path is the default for people with effective emotional self-regulation. 3.8. The long path. 3.9. The short path. In people with poor emotional self-regulation, such as patients with PTSD, this circuit is impaired. They startle easily and overreact to innocuous stimuli. The hippocampus cuts out the PFC. Instead of referring incoming threats to the wise discrimination of the primate brain, where the bang can be categorized as “car backfiring,” the hippocampus treats even mild stimuli as though they are life-threatening disasters and activates the amygdala. This short-circuit of the long path creates a short path: hippocampus > amygdala > FFF. The short circuit improves reaction speed, but at the expense of accuracy.

The Emory researchers who identified the four phases of meditation found that when meditators slip out of the focused attention of the TPN and into Mind Wandering, the DMN activates. The wandering mind of the DMN has a “me” orientation, focusing on the self. It may flit from what’s going on at the moment (“Is that a mosquito buzzing?”) to future worries (“I’m nervous about next week’s exam”) to the past (“I’m so mad at my brother Jim for calling me a sissy at my fifth birthday party”). The precuneus contributes to both self-referential focus and episodic memory. Disturbing memories are played and replayed. The idle brain defaults to what is bothering us, both recent and long-past events. These egocentric musings of the wandering mind form the fabric of our sense of self. When you quiet your TPN in meditation, you open up a big empty space in consciousness. For a few moments, the brain is quiet, and you feel inner peace. Then the engine starts revving. The DMN kicks in, bringing with it a cascade of worries and random thoughts. You’re doing 2,000 RPM in Park, but going nowhere. And it gets worse. The DMN has a rich neural network connecting it with other brain regions. Through this, it busily starts recruiting other brain regions to go along with its whining self-absorption. It commandeers the brain’s CEO, the prefrontal cortex. This impairs executive functions like memory, attention, flexibility, inhibition, planning, and problem-solving. 2.5. Nerves from the Default Mode Network reach out to communicate with many other parts of the brain. The DMN also recruits the insula, a region that integrates information from other parts of the brain. It has special neurons triggered by emotions that we feel toward other people, such as resentment, embarrassment, lust, and contempt. We don’t just think negative thoughts; we feel them emotionally too. At this stage, the meditator isn’t just wallowing in a whirlwind of self-centered thoughts. The DMN has taken the brain’s CEO hostage, while through the insula it starts replaying all the slights, insults, and disappointments we’ve experienced in our relationships. The quiet meditative space we experienced just a few moments before has been destroyed. This drives meditators absolutely nuts. No sooner do they achieve nirvana, the still, quiet place of Bliss Brain, than the DMN serves up a smorgasbord of self-absorbed fantasies. It pulls us into negative emotional states—then drags the rest of the brain along behind it. The DMN. Hmm . . . that acronym reminds me of something: “the DeMoN.” The DMN is the demon that robs me of the inner peace I’m seeking through meditation

The risk of Parkinson’s is increased if you have a mutation in a gene called GBA, which codes for one of the digestive enzymes involved in autophagy. Parkinson’s is accompanied by ‘Lewy bodies’, clumps of a protein called alpha-synuclein that are toxic to brain cells. The problematic, sticky form of alpha-synuclein is normally degraded by autophagy, but even a small impairment caused by a minor GBA mutation is enough to slow its breakdown, increase its levels and thus increase the risk of getting Parkinson’s. Impaired autophagy is also associated with Alzheimer’s and Huntington’s disease, arthritis and heart problems.

This is the system for self-reflection, and reflection about others, the area of the brain that is highly active when we are not focused on a task. It is the part of us that goes “off-line.” A healthy default mode network is necessary for the human brain to rejuvenate, store information in more permanent locations, gain perspective, process complicated ideas, and be truly creative. It has also been linked in young people to the development of a strong sense of identity and a capacity for empathy.19 Not surprisingly, stress impairs the default mode network’s ability to work its magic. Scientists are concerned that because of technology’s ubiquity, young people have too few opportunities to activate their default mode network and, as a result, too few opportunities for self-reflection.

Autism is usually defined not by its underlying mechanisms but by impaired social communication and repetitive behavior. One of the first things parents discover is that autistic children rarely solicit or reciprocate eye contact with caregivers, unlike normal infants. This difference becomes apparent by two to six months of age.61 There is nothing wrong with the eye movements in affected children; they simply look elsewhere.

The scientific literature shows that hunger, anger, loneliness, tiredness, pain, and stress are common “preconditions for poor decision making.” So Shubin Stein uses an acronym, HALT-PS, as a reminder to pause when those factors might be impairing his judgment and postpone important decisions until he’s in a state in which his brain is more likely to function well.* This is our seventh technique for reducing avoidable stupidity.

Biopsychiatrists at the Harvard Medical School have shown that mothers who frequently abuse their children even verbally can impair the circuitry of those kids’ brains.

Impaired glucose tolerance—a sign of eating too much sugar—is linked to relative cognitive impairment in older adults

Further, the hippocampus is one of the few regions in the human brain that can actually grow new neurons—yet glucocorticoids prevent the birth of neurons in the hippocampus, impairing its ability to produce new memories.

When we dream up alternative realities, we actually do serious cognitive work, requiring a wide spectrum of skills. Counterfactual thinking requires our minds to be fully engaged. We know this because humans with brain disorders, such as Parkinson’s disease, are more impaired in thinking counterfactually than for other cognitive tasks. They may have no difficulties speaking and reasoning, but they find it hard to envision alternatives to what exists.

Today, in the medical field, chemo brain is referred to as cancer-treatment-related cognitive impairment, cancer-related cognitive change, or post-chemotherapy cognitive impairment. I am not a fan of the word impairment in these phrases for reasons we’ll discuss in a moment, but nonetheless, chemo brain is a symptom reported by as many as 75 percent of cancer patients. It is often described as difficulty processing information and feeling as if you can’t think as quickly and as clearly as you did before you had cancer or started treatment. Everyday tasks require more concentration and take more time and effort to take care of. As you may have noticed, this is not too dissimilar from the brain fog experienced by

In a series of experiments involving hundreds of subjects, Princeton psychologist Diana Tamir and three colleagues examined how people's recording of their experiences, through online comments or digital photographs, influenced memory formation in three different scenarios: watching a lecture on a computer, taking a self-guided tour of a historic building alone, and taking the same tour in the company of another person. "Media use impaired memory for both computer-based and real-world experiences, in both solo and social contexts," the researchers reported in the Journal of Experimental Psychology. "Creating a hard copy of an experience through media leaves only a diminished copy in our own heads." With social media allowing and encouraging us to upload accounts of pretty much everything we do, this effect is now widespread. A 2017 Frontiers in Psychology survey of peer-reviewed research on how smartphones affect memory concluded that "when we turn to these devices, we generally learn and remember less from our experiences.

are classified and perceived differently than diseases of the body. Your brain forms your personality. Your behavior is the result of the disease, of the brain misfiring. It’s easier to separate blame and fault from an impaired kidney or a damaged aorta than from an obsessive, compulsive, phobic person.

These symptoms exemplify how impairing ADHD can be to a woman because they encompass just about all the facets of her life. Though “executive functioning” and “self-regulation” sound like terminology straight out of a college textbook, suffice it to say that these seemingly “absentminded” behaviors are, in fact, brain based, and there is a perfectly rational explanation for why you “do the things you do.

THE EIGHT GUIDING PRINCIPLES The eight guiding principles reveal how to detect and work with the energetic imbalances in the body. In fact, the principles consist of four polar opposites, which are as follows. INTERNAL/EXTERNAL Internal/external determines the location but not the cause of the problem. Internal organs are often affected by an emotional issue, and less frequently by an unknown cause or an external factor. External disorders are either caused by an outside-of-the-body pathogen that attacks suddenly or an acute or chronic invasion in the channel. External symptoms might involve the hair, muscles, and peripheral nerves and blood vessels, while internal systems involve the organs, deep vessels and nerves, brain, and spinal cord. HOT/COLD Hot/cold indicates the nature of the imbalance and the overall energy of the patient. Full heat or hot is excess heat in the interior. Excess heat is too much yang. Empty heat is deficient yin in the interior (usually caused by Kidney yin deficiency.) Full cold is excess cold in the interior. Excess cold comes from too much yin. Empty or deficient cold is a deficiency of yang. Hot and cold can coexist within the system. Cold symptoms might involve chills and pale skin, while hot symptoms could involve a raging fever and high metabolism. FULL/EMPTY Full/empty describes excess versus deficiency. It indicates the presence of a pathogen as well as the condition of the bodily chi. Full describes the presence of an internal or external pathogen or stagnated chi, blood, or food. Empty indicates no pathogen but weak chi, yin, yang, or blood. Mixed portrays the presence of a pathogen and weak chi, blood, yin, or yang. Full or excess symptoms often accompany a condition that is acute or sudden-onset, while empty or deficiency syndromes are more chronic and slow-moving. CHI, BLOOD, AND FLUIDS: THE THREE UNIFYING INGREDIENTS THE FOUR LEVELS, six stages, and eight principles all revolve around the same three bodily ingredients: chi, blood, and non-blood bodily fluids. While a serious illness involves all three, many problems revolve around issues with one or another. These are the main conditions involving blood, chi, or the fluids. CHI CONDITIONS Deficient chi: Not enough chi to perform the necessary functions. Sinking or collapsed chi: The Spleen chi cannot perform its supportive functions. Stagnated chi: The chi flow is impaired. If congested or stuck in an organ, there can be pain, sluggishness, or stiffness. Rebellious chi: The chi flows in the wrong direction.

The disappearance of medial prefrontal activation could explain why so many traumatized people lose their sense of purpose and direction. I used to be surprised by how often my patients asked me for advice about the most ordinary things, and then by how rarely they followed it. Now I understood that their relationship with their own inner reality was impaired.

Later abuse or other traumas did not account for dissociative symptoms in young adults.40 Abuse and trauma accounted for many other problems, but not for chronic dissociation or aggression against self. The critical underlying issue was that these patients didn’t know how to feel safe. Lack of safety within the early caregiving relationship led to an impaired sense of inner reality, excessive clinging, and self-damaging behavior: Poverty, single parenthood, or maternal psychiatric symptoms did not predict these symptoms.

Our brains differ as much as our bodies. Indeed, they may differ more. One part of the brain, the anterior commissure … varies seven-fold in area between one person and the next. Another part, the massa intermedia…, is not found at all in one in four people. The primary visual cortex can vary three-fold in area. Something called our amygdala (it is responsible for our fears and loves) can vary two-fold in volume—as can something called our hippocampus (involved in memory). Most surprisingly, our cerebral cortex varies in non-learning impaired people nearly two-fold in volume. Dr. John Robert Skoyles

once the reflexive brain is impaired, then the reflective areas say, “Hmm, maybe I should try that one.” Without the saving grace of fear, the analytical parts of the brain will keep trying to outsmart the odds, with disastrous results. “The process of deciding advantageously,” says Damasio, “is not just logical but also emotional.

The virus leaves behind tiny pieces of itself after the body breaks it down. These pieces, similar to fragments of the virus’s outer shell, can clump together into structures that trick the body into thinking there’s a bigger threat. This triggers an intense immune response, like sounding a massive alarm over a few leftover virus bits, which can contribute to severe inflammation and symptoms seen in serious COVID-19 cases. It's like the virus has a ghostly afterlife, continuing to affect the body even after the majority of it has been destroyed. In the battle against the virus, our body initiates a defense mechanism that, while protective, also causes inflammation in critical areas, particularly where our stem cells are nurtured including the bone marrow, gut, and brain. For instance, the mitochondria in our blood cells—often referred to as the cellular powerhouses responsible for energy production — are compromised. Their functionality is impaired; they either push themselves too hard or don’t work as efficiently as they should, leading to a notable decrease in the body's energy levels. This energy deficit is more than just feeling tired; it's a systemic issue affecting the body's ability to fight off the virus effectively. The T cells, which are supposed to eliminate any remaining virus, find themselves restrained rendering their arsenal less effective and their capacity to multiply weakened. Despite these limitations, they release copious amounts of interferon-gamma (IFN-γ), a signaling molecule that rallies the body's defenses to fight vigorously. This intense response may play a role in the virus's stubborn persistence and ongoing immune response. Meanwhile, the B cells are on overdrive, producing an excessive amount of antibodies in this heightened state of alert. This heightened immune response complicates the path to recovery, posing challenges for individuals striving to reclaim their sense of health and wellness.

A control group of people with undamaged brains readily learned to favor the forecaster whose predictions turned out to be most accurate. The prefrontal patients, however, made their judgments perceptually instead of conceptually, relying on what Grafman calls “cues that typically had nothing to do with a good choice.” One patient, for example, preferred the advisor whose image was displayed on a green background, “since it is springtime.” It seems that if the prefrontal cortex is impaired, the brain’s internal checks-and-balances system breaks down—and the reflexive areas may take over unopposed.

Grouping the participants by the number of blocks they reported walking each week, the team studied participants’ initial physical assessments and then followed up with MRI scans nine years later. Four years after that, the team tested the participants for cognitive impairment and dementia. The results were impressive. Those who’d walked regularly—about six to nine miles a week—had significantly more grey matter in the frontal, occipital, and hippocampal regions than those who walked less. Checking in thirteen years after participants’ initial assessments, Erickson’s team found that those who’d logged six to nine miles a week were far less likely to be cognitively impaired than those who walked the least.

The ability to control our focus—also called top-down attentional control—relies on the prefrontal cortex. It is the last part of the brain to develop, and it develops even more slowly in those with ADHD. And even once it is fully developed, it’s still impaired.

Stigma is a terrible word in the world of quiet sufferers. Cold Creek, and its staff of professionals, has worked closely with patients and families to relieve them of the shame associated with mental illness. When a patient presents with symptoms of diabetes or heart disease, and the treatment is lifelong, the general population accepts the diagnosis as a matter of physical health. Unfortunately, diseases of the brain are classified and perceived differently than diseases of the body. Your brain forms your personality. Your behavior is the result of the disease, of the brain misfiring. It’s easier to separate blame and fault from an impaired kidney or a damaged aorta

Excess muscle loss is known as sarcopenia, and is one of the most common causes of physical impairments later in life. It leads to further reductions in physical activity, bone loss, and increased joint, ligaments, tendon and other soft-tissue dysfunction contributing to injury and pain. The loss of muscle, and reduced muscle activity, can also impair brain function.

According to a large study from Kaiser Permanente, for every 0.05 increase above 4.72, patients had an additional 6 percent increased risk of developing diabetes in the next ten years (4.82 = 12 percent increased risk, etc.) Above 5 indicates that vascular damage has already occurred and a patient is at risk for having damage to the kidneys and eyes. Why is high fasting blood sugar a problem? High blood sugar causes vascular problems throughout your whole body, including your brain. Over time, it causes blood vessels to become brittle and vulnerable to breakage. It leads not only to diabetes but also to heart disease, strokes, visual impairment, impaired wound healing, wrinkled skin, and cognitive problems. Diabetes doubles the risk for Alzheimer’s disease.