Biological Clock Quotes

Biological clock? I don't even own a watch.

Mama Ginger came calling, to set the alarm on my biological clock. Oh, and to remind me that there’s no point to me being a woman if I never have children.” “Well, if that’s true, I wasted a hell of a lot of money on panty hose and lipstick.” Jettie snorted.

Do you hear that?” She asked. “It’s my biological clock ticking out of control.” “Hear that?” He offered his own puzzle and pushed his hips down hard into her softness. “It’s my dick wanting to fuck.

I always say my biological clock must be digital, because I've never heard it ticking.

Animal minds are simple, and therefore sharp. Animals never spend time dividing experience into little bits and speculating about all the bits they've missed. The whole panoply of the universe has been neatly expressed to them as things to (a) mate with, (b) eat, (c) run away from, and (d) rocks. This frees the mind from unnecessary thoughts and gives it a cutting edge where it matters. Your normal animal, in fact, never tries to walk and chew gum at the same time. The average human, on the other hand, thinks about all sorts of things around the clock, on all sorts of levels, with interruptions from dozens of biological calendars and timepieces. There's thoughts about to be said, and private thoughts, and real thoughts, and thoughts about thoughts, and a whole gamut of subconscious thoughts. To a telepath the human head is a din. It is a railway terminus with all the Tannoys talking at once. It is a complete FM waveband- and some of those stations aren't reputable, they're outlawed pirates on forbidden seas who play late-night records with limbic lyrics.

Here's the thing. I hate kids. Always have. I mean, I know the job of the race, biologically speaking, is to achieve immortality through reproduction, but the idea of getting impregnated and blowing up like a balloon as I serve as a carrier and service unit for this other person who will eventually burst out of me in the most terrifying way imaginable, then carry on using me one way or another for the rest of my life, is right up there with throwing myself off the top of a twenty-story building. If I have a biological clock, it is digital and does not tick.

My name is Bear. I am a reluctant homosexual (or, at least, I resemble one). My boyfr—er, life partner (gag!), is apparently like a forty-year-old woman, and his biological clock is exploding all over the place, and we don’t know how to turn off the alarm. We need a woman (ha!) to allow us to put our sperm into her so that we can create the miracle that is life! You, as the surrogate, must not be crazy!!!!!

Let us crush these so-called biological clocks that give us nothing but fear, and encourage us to make stupid decisions. Let us crush these biological clocks that hurt us and rob us of the fabulous lives that Jesus died to give us. These clocks that not only hurt us, but hurt many generations after us. It is time. We need you.

Of course, the problem is that we don’t live in a world just of women. Not only do men exist, but we are drawn to them and, for complex reasons, they do not treasure time in the same way that we do. It may have to do with an inability to face mortality, or needs of ego, or maybe it simply has to do with the fact that they don’t hear the ticking of a biological clock. What I can say with certainty is that a man has no problem wasting time, especially that of a woman. And they manage to do so in such insidious ways we often don’t notice that it’s happening until it’s too late.

our system puts the career clock and the female biological clock in direct conflict.

Physics says: go to sleep. Of course you’re tired. Every atom in you has been dancing the shimmy in silver shoes nonstop from mitosis to now. Quit tapping your feet. They’ll dance inside themselves without you. Go to sleep. Geology says: it will be all right. Slow inch by inch America is giving itself to the ocean. Go to sleep. Let darkness lap at your sides. Give darkness an inch. You aren’t alone. All of the continents used to be one body. You aren’t alone. Go to sleep. Astronomy says: the sun will rise tomorrow, Zoology says: on rainbow-fish and lithe gazelle, Psychology says: but first it has to be night, so Biology says: the body-clocks are stopped all over town and History says: here are the blankets, layer on layer, down and down.

And I love you and your biological clock is ticking so we best get started on that shit.

My biological clock is ticking so loudly that it’s keeping me awake at night.

A particularly significant example of brain against body, or measures against matter, is urban man’s total slavery to clocks. A clock is a convenient device for arranging to meet a friend, or for helping people to do things together, although things of this kind happened long before they were invented. Clocks should not be smashed; they should simply be kept in their place. And they are very much out of place when we try to adapt our biological rhythms of eating, sleeping, evacuation, working, and relaxing to their uniform circular rotation. Our slavery to these mechanical drill masters has gone so far and our whole culture is so involved with it that reform is a forlorn hope; without them civilization would collapse entirely. A less brainy culture would learn to synchronize its body rhythms rather than its clocks.

Late twenties, single, female. Do the math. Flirty flings were fabulous until you hit the big three-O, all downhill from there. Biological clocks started ticking like time bombs waiting to detonate, gravity exerted more force on your life than your mom, and suddenly, the dog-ugliest creep looked like Jake Gyllenhaal.

women have a second biological clock, and it is equally as valuable as the 24-hour clock. The 28-day clock can be measured; it is predictable; and it demands the same respect, attention, and priority as the 24-hour clock.

Billy looked at the clock on the gas stove. He had an hour to kill before the saucer came. He went into the living room, swinging the bottle like a dinner bell, turned on the television. He came slightly unstuck in time, saw the late movie backwards, then forwards again. It was a movie about American bombers in the Second World War and the gallant men who flew them. Seen backwards by Billy, the story went like this: American planes, full of holes and wounded men and corpses took off backwards from an airfield in England. Over France a few German fighter planes flew at them backwards, sucked bullets and shell fragments from some of the planes and crewmen. They did the same for wrecked American bombers on the ground, and those planes flew up backwards to join the formation. The formation flew backwards over a German city that was in flames. The bombers opened their bomb bay doors, exerted a miraculous magnetism which shrunk the fires, gathered them into cylindrical steel containers, and lifted the containers into the bellies of the planes. The containers were stored neatly in racks. The Germans below had miraculous devices of their own, which were long steel tubes. They used them to suck more fragments from the crewmen and planes. But there were still a few wounded Americans, though, and some of the bombers were in bad repair. Over France, though, German fighters came up again, made everything and everybody as good as new. When the bombers got back to their base, the steel cylinders were taken from the racks and shipped back to the United States of America, where factories were operating night and day, dismantling the cylinders, separating the dangerous contents into minerals. Touchingly, it was mainly women who did this work. The minerals were then shipped to specialists in remote areas. It was their business to put them into the ground., to hide them cleverly, so they would never hurt anybody ever again. The American fliers turned in their uniforms, became high school kids. And Hitler turned into a baby, Billy Pilgrim supposed. That wasn't in the movie. Billy was extrapolating. Everybody turned into a baby, and all humanity, without exception, conspired biologically to produce two perfect people named Adam and Eve, he supposed.

Today I am in my mid-30s and I still do not hear my biological clock tick. [ … ] neither my body nor my psyche are telling me that my time has come, but only society.

Time is relative. In human life, time is experience. The faster you archive a significant experience to your memory, the more you live in the same clock time. In physics, experience is represented by the distance traveled, and this entire thing is called the Relativity of Time. I want to age and die through archiving my experiences, not watching my biological clock. Please don't waste my clock time with mediocrity and egotism, let me use it towards serving to others.

Another clue to the cause of aging might be telomerase, which helps to regulate our biological clock. Every time a cell divides, the tips of the chromosomes, called telomeres, get a bit shorter. Eventually, after approximately fifty to sixty divisions, the telomeres become so short that they disappear and the chromosome begins to fall apart, so the cell enters a state of senescence and no longer functions correctly. Thus there is a limit to how many times a cell can divide, called the Hayflick limit.

I write this in the moonlight, straining my ears to hear beyond the cold mechanical clock to the warm biological noises of the night, but my being is attuned only to one thing, the relentless rhythm of time. If I could only smash the clock and stop time from advancing! Crush the infernal machine! Shatter its bland face and rip those cursed hands from their torturous axis of circumscription! I can almost feel the sturdy metal body crumpling beneath my hands, the glass fracturing, the case cracking open, my fingers digging into the guts, spilling springs and delicate gearing. But now, there is now use, now way of stopping time.

The pineal gland is activated by light and controls the body's bio- rhythms in concert with the hypothalamus gland which regulates hunger, thirst, sexual desire and the biological clock that dictates how fast we age. Look at the potential for mass control if you can externally suppress and manipulate the pineal and hypothalamus glands alone. You can make it much harder to perceive beyond the five senses, decide how quickly people age, how much they want sex, when they are hungry and thirsty and for how long. This is the key reason for putting sodium fluoride into water supplies and toothpaste. The pineal gland absorbs more fluoride than any other part of the body and becomes calcified by this highly-damaging toxin. Sodium fluoride is an appalling waste product of the aluminum industry and has been used in rat poison. It causes cancer, genetic damage, Alzheimer's disease, disrupts the endocrine system and dumbs down the brain. It was added to drinking water in the Nazi concentration camps to make the inmates more acquiescent and docile.

Ami leaned into his side and inhaled the fresh scent of man. “Uh, no. Sometimes my biological clock threatens to explode like a ticking bomb, that’s all. Rachel is so lucky. Nat is a doll. Doug adores them. Don’t mind me, I’m just wishing my laundry pile was filled with boxer shorts and Cinderella T-shirts. I’ll get over it.” “Why do you have to get over it,” Marcus asked gently. “Sounds like a nice dream to me.” ...a few pages later Things were looking up. If he could just convince her his boxer shorts belonged in her laundry basket, he’d be right on board with her six-month plan

It is not biology alone but heroism too that drives women to find the will and grit and creativity to put one’s own impulses aside to serve the needs of a tiny creature around the clock—especially in an environment in which that heroic choice is only casually acknowledged, much less honored, cherished, or assisted. I believe the myth about the ease and naturalness of mothering—the ideal of the effortlessly ever-giving mother—is propped up, polished, and promoted as a way to keep women from thinking clearly and negotiating forcefully about what they need from their partners and from society at large in order to mother well, without having to sacrifice themselves in the process.

Even the primary visual areas in the brain show the special organizing function of space. Each patch of cortical real estate is dedicated to a fixed spot in the visual field, and contours in the world are represented as contours across the surface of the brain, at least on a large scale. Time also has a presence in the mind that is more than just any old attribute of an experience. Neuroscientists have found biological clocks ticking in the brains of organisms as simple as fruit flies. And just as we see stuff that is connected in space as an object, we see stuff that is connected in time as a motion, such as a trajectory or gesture, or, in the case of sound, as a melody or stretch of speech.

The phase of an individual’s body clock in relationship to a zeitgeber is a biological phenomenon and not a matter of discipline.

The whole panoply of the universe has been neatly expressed to them as things to (a) mate with, (b) eat, (c) run away from, and (d) rocks. This frees the mind from unnecessary thoughts and gives it a cutting edge where it matters. Your normal animal, in fact, never tries to walk and chew gum at the same time. The average human, on the other hand, thinks about all sorts of things around the clock, on all sorts of levels, with interruptions from dozens of biological calendars and time-pieces. There’s thoughts about to be said, and private thoughts, and real thoughts, and thoughts about thoughts, and a whole gamut of subconscious thoughts.

Crushes thrive in small spaces. Humans must be programmed to respond positively when faced with a small sampling of other humans in, say, caves. You're stuck in a cave with three other people - all mankind, presumably, was hidden away in such tiny groups during the winters until the thaw - and so, in order for the species to thrive, you must be biologically compelled to fuck at least one person in your cave, despite the fact that, when surrounded by a plenitude of Neanderthals at the Neanderthal summer barbecue, none of them struck your fancy. Without the element of choice, and in conjunction with captivity, you find love, or at least you find lust.

But why does she want them, really? Because Susan has them? Because the Salem bookstore manager has them? Because she always vaguely assumed she would have them herself? Or does the desire come from some creaturely place, pre-civilized, some biological throb that floods her bloodways with the message Make more of yourself! To repeat, not to improve.

To begin with, this world has a different kind of time. It is the time of biological rhythm, not of the clock and all that goes with the clock. There is no hurry. Our sense of time is notoriously subjective and thus dependent upon the quality of our attention, whether of interest or boredom, and upon the alignment of our behavior in terms of routines, goals, and deadlines. Here the present is self-sufficient, but it is not a static present. It is a dancing present, the unfolding of a pattern which has no specific destination in the future but is simply its own point. It leaves and arrives simultaneously, and the seed is as much the goal as the flower. There is therefore time to perceive every detail of the movement with infinitely greater richness of articulation. Normally we do not so much look at things as overlook them.

— Well, while I was trying to break away from Laura, the image of an amoeba that splits in two suddenly came to mind – something I hadn't thought about since my biology class in high school. I was like the two halves of the amoeba that separate piece by piece, until there is only a thin trickle left to bind us. And then a noise – a painful crackling – and we separated. I got out of bed, got dressed, looked at the clock, and thought, "Just fourteen hours until I'm going to be in bed with Laura again, holding us in my arms." And then I came here.

For it is not cell nuclei, not even individual chromosomes, but certain parts of certain chromosomes from certain cells that must be isolated and collected in enormous quantities for analysis; that would be the precondition for placing the chemist in such a position as would allow him to analyse [the hereditary material] more minutely than [can] the morphologists ... For the morphology of the nucleus has reference at the very least to the gearing of the clock, but at best the chemistry of the nucleus refers only to the metal from which the gears are formed.

To be critical of pronatalism is not equivalent to condemning parenthood; it is to shed light on its prescriptive nature and propose that it would be socially and ecologically desirable that parenthood cease to be considered as a natural instinct and/or a religious or a social duty. The ‘biological clock’ that some women claim to hear ticking is also a ‘social clock’ reminding them that whatever else may be going on in their lives, motherhood is their destiny, the road to social acceptance and integration. It is because parenthood is not a natural instinct, but socially and prescriptively imposed, that many people unsuited for family formation bear or adopt children; domestic violence and child abuse result from the often deadly interaction between sexual inequality and pronatalism. Today, pronatalist ideologies and social pressures continue to curtail women’s opportunities and ability to shape their future, and place them in a disadvantaged position relative to men, thus sustaining the inequality between men and women despite considerable gains in sexual liberation, civil rights, and economic opportunities for women.

The role played by stress in the causation of cancer is so great that it would not be an exaggeration to say that 80% or more cancer cases have their immediate origin in some form of mental pressure or strain. Grief, distress, fear, worry, and anger are emotions which have horrible effects on the body's functions. Researchers have discovered that these emotions cause the release of chemicals from the brain called neuropeptides. These potent compounds have a profound immune-suppressive action. Scientists have traced a pathway from the brain to the immune cells proving that negative emotions can stop the immune cells dead in their tracks. This results in part from the release of chemicals from nerve endings. Once this happens, harmful microbes or cancer cells can invade any tissue in the body.

After I composed myself, Sister Janja told me this little boy’s story. He was placed in the orphanage at a young age when his mother, a single parent, became unable to care for him due to disability. Sister said that a beautiful and loving family adopted Boris a couple of years ago. She also said that she had not heard anything more about the child in years until just recently, when she was told a remarkable story. About three weeks earlier, Boris had woken up at one o’clock in the morning and had run into his parents’ room in tears. When his mother asked him what was wrong, he said between sobs that he had dreamed she had died. The mother hugged her son and assured him that she was just fine, letting him sleep the rest of the night between her and her husband. At eight o’clock the next morning, Boris’s mother got a call from a woman at the social services office in Central Bosnia. She called to say that Boris’s biological mother had passed away in the night.

By the late 20th century, the idea that parents can harm their children by abusing and neglecting them (which is true) grew into the idea that parents can mold their children’s intelligence, personalities, social skills, and mental disorders (which is not). Why not? Consider the fact that children of immigrants end up with the accent, values, and norms of their peers, not of their parents. That tells us that children are socialized in their peer group rather than in their families: it takes a village to raise a child. And studies of adopted children have found that they end up with personalities and IQ scores that are correlated with those of their biological siblings but uncorrelated with those of their adopted siblings. That tells us that adult personality and intelligence are shaped by genes, and also by chance (since the correlations are far from perfect, even among identical twins), but are not shaped by parents, at least not by anything they do with all their children. Despite these refutations, the Nurture Assumption developed a stranglehold on professional opinion, and mothers have been advised to turn themselves into round-the-clock parenting machines, charged with stimulating, socializing, and developing the characters of the little blank slates in their care.

But then a peculiar thing happened. I became extraordinarily affected by the summer afternoons in the laboratory. The August sunlight came streaming in the great dusty fanlights and lay in yellow bars across the room. The old building ticked and creaked in the heat. Outside we could hear the cries of summer students playing touch football. In the course of an afternoon the yellow sunlight moved across old group pictures of the biology faculty. I became bewitched by the presence of the building; for minutes at a stretch I sat on the floor and watched the motes rise and fall in the sunlight. I called Harry’s attention to the presence but he shrugged and went on with his work. He was absolutely unaffected by the singularities of time and place. His abode was anywhere. It was all the same to him whether he catheterized a pig at four o’clock in the afternoon in New Orleans or at midnight in Transylvania. He was actually like one of those scientists in the movies who don’t care about anything but the problem in their heads - now here is a fellow who does have a “flair for research” and will be heard from. Yet I do not envy him. I would not change places with him if he discovered the cause and cure of cancer. For he is no more aware of the mystery which surrounds him than a fish is aware of the water it swims in. He could do research for a thousand years and never have an inkling of it.

Well, while you’re at the shop you’d better stock up on batteries.’ Penelope folded her arms. ‘Pardon?’ Grace shot Penelope a wary look. ‘For your biological clock. It seems to have stopped working.

Who knew holding a baby would make my biological clock tick so loudly, it could be heard in another dimension.

I will no longer get weighted down, From so-called friends & family talks, About the concern for my biological clock When I serve the Author of Time. Who is NOT subject to time, But I’M subject to Him, He has the ability to STOP, FAST FORWARD, PAUSE, or REWIND at any given time…

15.   Baby is not being exposed to adequate amounts of daylight. Explanation/Recommendation: Natural light is important to help babies regulate their circadian clock. This is the inner clock, the biological time-keeping system that regulates daily activities, such as sleep and wake cycles. We recommend that, as soon as your baby awakens in the morning, you take him to a room filled with daylight (although he does not need to be in direct sunlight). Natural light, along with the first feeding of the day, will help establish his circadian rhythm and keep them consistent. Routine helps facilitate this amazing function possessed by all humans.

It’s like his biological clock has started counting down, instead of mine.

By age 35, 95 to 99 percent of your thoughts and actions originate from the habitual programming of the subconscious mind—a combination of memorized behaviors, emotional reactions, beliefs, and perceptions that run in the background like an app on your smartphone.

I can accept that, when it comes to an artistic decision, checking that something works physically is not an artist’s top priority. I don’t complain that Picasso’s works are biologically implausible or send Salvador Dalí angry letters about the melting point of clocks.

So long as they are reliably repeating, the brain can also use other external cues, such as food, exercise, temperature fluctuations, and even regularly timed social interaction. All of these events have the ability to reset the biological clock, allowing it to strike a precise twenty-four-hour note.

The situation becomes even more fraught for women in their late thirties and forties whose biological clocks are ticking. Donovan told me that women at such gatherings often try to get to eligible men they want to meet early on, lest someone else get to them first and make a connection. On the rare instance when a new single guy enters the room, Donovan described an 'almost palpable, heightened state of awareness' among the women. They know - even if they're loath to admit it - 'that a competition has just begun

Plus, Ronke’s biological clock was deafening. And when it came to marriage and babies, she had backward, African, views – all women wanted to be mothers. Anyone who didn’t was a freak.

Guess what, Steve—your clock isn’t just a clock. It actually controls time!” (If you’re curious to know your own level of methylation and your epigenetic biological age, Sinclair’s team will soon be marketing a test based on a quick and painless cheek swab. It promises a turnaround time of just a few days and has a real cost of only a dollar.)

Some Negative Reasons People Have Children: Babylust The Biological Clock Pressure from Media, Family, and Friends Fear of Missing Out Proving Our Parenting Skills Avoiding Being Mislabeled or Misunderstood Idealization of Child Rearing

Clocks should not be smashed; they should simply be kept in their place. And they are very much out of place when we try to adapt our biological rhythms of eating, sleeping, evacuation, working, and relaxing to their uniform circular rotation

but then she hadn’t turned thirty yet. Something happens in your brain when you do, I swear. I don’t know if it’s society or culture or the biological clock or witchcraft or what. But it’s real. And I don’t think blokes have it.

In order to resist this overemphasis on the ticking biological clock, the church needs to articulate a strong and positive vision in relation to aging. Although peer-group ministry has some important advantages, we also need to reintegrate the different generations within the church. Mature and wise exemplars within the community train us to join confidently with Paul’s conviction that even as the body ages, the inner self is being renewed.

he left for, like, six hours, at eleven o’clock at night, and when he came home I told him that if he left us, he’d be a biological coward.” “A biological coward?” “If you leave someone when she’s pregnant with your child you’re solidifying the fact that you’re evolutionarily weak. Which most men are, in my opinion, but not quite so overtly.

The average human, on the other hand, thinks about all sorts of things, around the clock, on all sorts of levels, with interruptions from dozens of biological calendars and timepieces. There’s thoughts about to be said, and private thoughts, and real thoughts, and thoughts about thoughts, and a whole gamut of subconscious thoughts. To a telepath the human head is a din. It is a railway terminus with all the Tannoys talking at once. It is a complete FM waveband – and some of those stations aren’t reputable, they’re outlawed pirates on forbidden seas who play late-night records with limbic lyrics.

The wanting of children seems to be an accepted universal fact for women everywhere. Not to play the trans exception card, but I'm sorry, it's not the same for transsexuals. It's not considered natural when I say that my biological clock is ticking, because I'm not granted a biological clock in the first place. I ache when I see other moms with kids. I'm so jealous. It's a jealousy of my body, like hunger. I want children near me. I want that same validation that other moms have. That feeling of womanhood placed in a family. That validation is fine for cis women, but it gets treated as perverted for me. Like, the only reason 'a man in a dress' would want to be near kids is not a good one. Let's come out and admit it: Everyone acts like moms are real women and real women become moms. Women who never have kids get treated like silly whores, obsessed with themselves, lacking some basic capacity to love.

her with a whole lot more than that, and the beautiful son or daughter they would have would experience a much better childhood than she had—a son or daughter Serena would need to have very soon, because her biological clock was now ticking pretty loudly.

Living in the city changed the biological clocks of birds. City birds got less sleep than rural birds.

It’s not that I don’t want kids, but I’ve just never felt particularly drawn to motherhood. Babies don’t make me coo and weaken, and I’ve never experienced any sort of biological clock about my reproductive window.

My biological clock may be ticking, but I can’t hear it properly due to the singing cuckoo.

In 2017, three research physiologists won the Nobel Prize for their four decades of work unraveling the mysteries of the circadian rhythm in biology. They found that the diurnal rhythm of nature affects the functioning of cells in plants, animals, humans, and even some single-cell bacteria. Specific genes change the function of cells based on the time of day. While this may seem like an esoteric set of discoveries, the new field of chronobiology has practical applications that have revolutionary implications for the future of wellness.

all of these diseases are caused by biological aging.

Simply put, biological aging is the single greatest risk factor for disease and death.

biological age is more about your personal multidimensional profile than any single lab test.

Knowing and working to improve our biological age will help us live longer,

your own biology and cannot be treated as a “one size fits all” solution.

The power of biological age comes down to the fact that it is modifiable.

application of biological age in tracking more sustained health behaviors.

Your biological age on any given day is not your destiny. It is what we call a “modifiable risk factor.

it is more important to assess the degree to which your biological profile has changed over time rather than the number of trips you have taken around the sun.

Longevity escape velocity(LEV) is a hypothetical situation in which one's remaining life expectancy (not LE at birth) is extended longer than the time that is passing. For example, in a given year in which LEV would be maintained, technological advances would increase people's remaining life expectancy more than the year that just went by. From Aubrey De Grey, the founder of LEV foundation himself: "My current estimate is that we will reach LEV, which is tantamount to defeating aging completely, within 12–15 years with 50% probability." "David Sinclair and I both made important contributions to the field 20-25 years ago, which gave us the option to get the media interested in us, and we chose to exercise that option because, and this may shock you, we are not scientists first and foremost, but humanitarians. We view the quest to understand aging better as a means to an end, namely to postpone the ILL-HEALTH of old age as much as possible, thereby saving lives and alleviating suffering on a totally unprecedented scale. When you ask how well respected David is as a scientist, you're actually (unintentionally, to be sure) asking a rather loaded question. Like me, he has chosen to sacrifice some of the respect he could have had, simply in order to save more lives." "I've often been asked what the life expectancy will be in the year 3000. My answer is there very (and I mean VERY) probably won’t be one. Obviously there won’t be one if the human race has ceased to exist, which quite a few people think is quite likely, but discounting that, in addressing the question we need to start by understanding what the term “life expectancy” actually means when it is applied to humans. My full answer to this here: quora .com/What-will-be-the-life-expectancy-in-the-year-3000 So the question now is “how would it work in practice?" Say you are 60 years old at the time of the first intervention and that this early and fundamentally imperfect treatment repairs 75% of the accumulated damage and winds the clock back by 25 years. Then 10 years later you would reach the chronological age of 70 but would be biologically only 45 years old and look and feel like a 45 year old. We now come to the vital key to the whole theory which is this, let's say 20 years after the first treatment, when you are chronologically 80 but biologically 55 years old, both your doctor and yourself will realize that the damage that was not repaired in the first treatment combined with the further damage accumulated over the 20 years since is again posing a health risk. At this point it is time for another intervention. It is now that the progress in medicine comes into play because, by the time 20 years has gone by, anti-aging medicine will have progressed significantly and, whilst the first treatment bought you an extra 25 or 30 years by repairing a fair amount of the damage accumulated over your first 60 years, it did not repair it all. 20 years later medical progress will mean that the latest treatment can not only repair all of the damage corrected by the first intervention but also some of the damage that was not able to be repaired 20 years earlier so in essence you are now chronologically 80 (but biologically in your 50s). This means that, whilst you will have aged 20 years chronologically you will be biologically younger after the second intervention than you were after the first. This is the essence of ADGs theory and pretty much any other theory based on rejuvenation and damage repair, essentially, it's a shortcut to radical life extension. It is not a cure but it acknowledges that it does not need to be because it simply buys time and leads to a situation where regular interventions at say 15/20 year intervals with increasing effective treatments could extend life virtually indefinitely. Will it happen? At this point, there is no doubt that it will happen eventually.

Three American business school professors decided to find out. In a first-of-its-kind study, they analyzed more than 26,000 earnings calls from more than 2,100 public companies over six and a half years using linguistic algorithms similar to the ones employed in the Twitter study. They examined whether the time of day influenced the emotional tenor of these critical conversations—and, as a consequence, perhaps even the price of the company’s stock. Calls held first thing in the morning turned out to be reasonably upbeat and positive. But as the day progressed, the “tone grew more negative and less resolute.” Around lunchtime, mood rebounded slightly, probably because call participants recharged their mental and emotional batteries, the professors conjectured. But in the afternoon, negativity deepened again, with mood recovering only after the market’s closing bell. Moreover, this pattern held “even after controlling for factors such as industry norms, financial distress, growth opportunities, and the news that companies were reporting.”8 In other words, even when the researchers factored in economic news (a slowdown in China that hindered a company’s exports) or firm fundamentals (a company that reported abysmal quarterly earnings), afternoon calls “were more negative, irritable, and combative” than morning calls.9 Perhaps more important, especially for investors, the time of the call and the subsequent mood it engendered influenced companies’ stock prices. Shares declined in response to negative tone—again, even after adjusting for actual good news or bad news—“leading to temporary stock mispricing for firms hosting earnings calls later in the day.” While the share prices eventually righted themselves, these results are remarkable. As the researchers note, “call participants represent the near embodiment of the idealized homo economicus.” Both the analysts and the executives know the stakes. It’s not merely the people on the call who are listening. It’s the entire market. The wrong word, a clumsy answer, or an unconvincing response can send a stock’s price spiraling downward, imperiling the company’s prospects and the executives’ paychecks. These hardheaded businesspeople have every incentive to act rationally, and I’m sure they believe they do. But economic rationality is no match for a biological clock forged during a few million years of evolution. Even “sophisticated economic agents acting in real and highly incentivized settings are influenced by diurnal rhythms in the performance of their professional duties.

P1 - Longevity escape velocity(LEV) is a hypothetical situation in which one's remaining life expectancy (not LE at birth) is extended longer than the time that is passing. For example, in a given year in which LEV would be maintained, technological advances would increase people's remaining life expectancy more than the year that just went by. From Aubrey De Grey, the founder of LEV foundation himself: "My current estimate is that we will reach LEV, which is tantamount to defeating aging completely, within 12–15 years with 50% probability." "David Sinclair and I both made important contributions to the field 20-25 years ago, which gave us the option to get the media interested in us, and we chose to exercise that option because, and this may shock you, we are not scientists first and foremost, but humanitarians. We view the quest to understand aging better as a means to an end, namely to postpone the ILL-HEALTH of old age as much as possible, thereby saving lives and alleviating suffering on a totally unprecedented scale. When you ask how well respected David is as a scientist, you're actually (unintentionally, to be sure) asking a rather loaded question. Like me, he has chosen to sacrifice some of the respect he could have had, simply in order to save more lives." "I've often been asked what the life expectancy will be in the year 3000. My answer is there very (and I mean VERY) probably won’t be one. Obviously there won’t be one if the human race has ceased to exist, which quite a few people think is quite likely, but discounting that, in addressing the question we need to start by understanding what the term “life expectancy” actually means when it is applied to humans. My full answer to this here: quora .com/What-will-be-the-life-expectancy-in-the-year-3000 So the question now is “how would it work in practice?" Say you are 60 years old at the time of the first intervention and that this early and fundamentally imperfect treatment repairs 75% of the accumulated damage and winds the clock back by 25 years. Then 10 years later you would reach the chronological age of 70 but would be biologically only 45 years old and look and feel like a 45 year old. We now come to the vital key to the whole theory which is this, let's say 20 years after the first treatment, when you are chronologically 80 but biologically 55 years old, both your doctor and yourself will realize that the damage that was not repaired in the first treatment combined with the further damage accumulated over the 20 years since is again posing a health risk. At this point it is time for another intervention. It is now that the progress in medicine comes into play because, by the time 20 years has gone by, anti-aging medicine will have progressed significantly and, whilst the first treatment bought you an extra 25 or 30 years by repairing a fair amount of the damage accumulated over your first 60 years, it did not repair it all. 20 years later medical progress will mean that the latest treatment can not only repair all of the damage corrected by the first intervention but also some of the damage that was not able to be repaired 20 years earlier so in essence you are now chronologically 80 (but biologically in your 50s). This means that, whilst you will have aged 20 years chronologically you will be biologically younger after the second intervention than you were after the first. This is the essence of ADGs theory and pretty much any other theory based on rejuvenation and damage repair, essentially, it's a shortcut to radical life extension. It is not a cure but it acknowledges that it does not need to be because it simply buys time and leads to a situation where regular interventions at say 15/20 year intervals with increasing effective treatments could extend life virtually indefinitely. Will it happen? At this point, there is no doubt that it will happen eventually. It's not a question of if but when.

Longevity escape velocity(LEV) is a hypothetical situation in which one's remaining life expectancy (not LE at birth) is extended longer than the time that is passing. For example, in a given year in which LEV would be maintained, technological advances would increase people's remaining life expectancy more than the year that just went by. From Aubrey De Grey, the founder of LEV foundation himself: "My current estimate is that we will reach LEV, which is tantamount to defeating aging completely, within 12–15 years with 50% probability." "David Sinclair and I both made important contributions to the field 20-25 years ago, which gave us the option to get the media interested in us, and we chose to exercise that option because, and this may shock you, we are not scientists first and foremost, but humanitarians. We view the quest to understand aging better as a means to an end, namely to postpone the ILL-HEALTH of old age as much as possible, thereby saving lives and alleviating suffering on a totally unprecedented scale. When you ask how well respected David is as a scientist, you're actually (unintentionally, to be sure) asking a rather loaded question. Like me, he has chosen to sacrifice some of the respect he could have had, simply in order to save more lives." "I've often been asked what the life expectancy will be in the year 3000. My answer is there very (and I mean VERY) probably won’t be one. Obviously there won’t be one if the human race has ceased to exist, which quite a few people think is quite likely, but discounting that, in addressing the question we need to start by understanding what the term “life expectancy” actually means when it is applied to humans. My full answer to this here: quora .com/What-will-be-the-life-expectancy-in-the-year-3000 So the question now is “how would it work in practice?" Say you are 60 years old at the time of the first intervention and that this early and fundamentally imperfect treatment repairs 75% of the accumulated damage and winds the clock back by 25 years. Then 10 years later you would reach the chronological age of 70 but would be biologically only 45 years old and look and feel like a 45 year old. We now come to the vital key to the whole theory which is this, let's say 20 years after the first treatment, when you are chronologically 80 but biologically 55 years old, both your doctor and yourself will realize that the damage that was not repaired in the first treatment combined with the further damage accumulated over the 20 years since is again posing a health risk. At this point it is time for another intervention. It is now that the progress in medicine comes into play because, by the time 20 years has gone by, anti-aging medicine will have progressed significantly and, whilst the first treatment bought you an extra 25 or 30 years by repairing a fair amount of the damage accumulated over your first 60 years, it did not repair it all. 20 years later medical progress will mean that the latest treatment can not only repair all of the damage corrected by the first intervention but also some of the damage that was not able to be repaired 20 years earlier so in essence you are now chronologically 80 (but biologically in your 50s). This means that, whilst you will have aged 20 years chronologically you will be biologically younger after the second intervention than you were after the first. This is the essence of ADGs theory and pretty much any other theory based on rejuvenation and damage repair, essentially, it's a shortcut to radical life extension. It is not a cure but it acknowledges that it does not need to be because it simply buys time and leads to a situation where regular interventions at say 15/20 year intervals with increasing effective treatments could extend life virtually indefinitely. Will it happen? At this point, there is no doubt that it will happen eventually. It's not a question of if but when.

Telomeres have been called “cellular clocks,” in that they are a measure of biological rather than chronological age. Two people, even identical twins, could be the same age as computed in years, months, weeks, and days, yet one may be biologically older than the other, depending on how much stress, adversity, or trauma they have endured. That’s because stress shortens telomeres. (Doctors should take special heed: the telomeres of medical residents suffer greater attrition than those of other young adults in their age group.)

He had heard about her biological clock ticking so often that he felt like Captain Hook in Peter Pan.

But that’s only the beginning of the trouble. The abused, isolated girls with incest histories mature sexually a year and a half earlier than the nonabused girls. Sexual abuse speeds up their biological clocks and the secretion of sex hormones. Early in puberty the abused girls had three to five times the levels of testosterone and androstenedione, the hormones that fuel sexual desire, as the girls in the control group.

She faced him. “I have to, Lee. In a few weeks, you’ll be gone. Until then, there’s nothing more between us than sex.” “You mean really great sex.” She let out a short, painful laugh. “Spectacular sex. But that’s all this is. Hell, my biological clock will be going off soon. What would you do then?” “Get rid of the condoms.

There was so much to worry about: God finding the man in time, God preserving a few good eggs in Cynthia’s aging insides, the man being “God’s choice for Cynthia,” and keeping the lost millions from getting sick and dying before Cynthia could get there and do her stuff and save them. All sorts of clocks were ticking: biological, spiritual, eternal . . . and she’d have to learn the language first! Between the babies, learning the language, finding a man—and this didn’t even address the issue of the funds to get out there—how could God do it all before the change? The quest for Cynthia’s husband and the state of her withering ovaries became a major obsession of my childhood. “Have you found anyone yet?” I would ask. “No, but there are two Koreans coming up next weekend from the University of Lausanne,” Cynthia said. Cynthia

A mage lived for a very long time. As children, they aged normally and usually developed magic at some point during early adolescence. Later, the biological clock began to slow once a mage reached his or her late twenties. Some of the greatest and most powerful wizards remained in active shape long into their second and third centuries.

Huygens noticed one day that a set of pendulum clocks placed against a wall happened to be swinging in perfect chorus-line synchronization. He knew that the clocks could not be that accurate. Nothing in the mathematical description then available for a pendulum could explain this mysterious propagation of order from one pendulum to another. Huygens surmised, correctly, that the clocks were coordinated by vibrations transmitted through the wood. This phenomenon, in which one regular cycle locks into another, is now called entrainment, or mode locking. Mode locking explains why the moon always faces the earth, or more generally why satellites tend to spin in some whole-number ratio of their orbital period: 1 to 1, or 2 to 1, or 3 to 2. When the ratio is close to a whole number, nonlinearity in the tidal attraction of the satellite tends to lock it in. Mode locking occurs throughout electronics, making it possible, for example, for a radio receiver to lock in on signals even when there are small fluctuations in their frequency. Mode locking accounts for the ability of groups of oscillators, including biological oscillators, like heart cells and nerve cells, to work in synchronization. A spectacular example in nature is a Southeast Asian species of firefly that congregates in trees during mating periods, thousands at one time, blinking in a fantastic spectral harmony.

We’re living in an acquisitive capitalist society that is fundamentally anti-family and fundamentally uncomfortable with just enjoying being human. We’d rather shop than live, acquire than love and stare into a screen than hold each other. The pressure parents put on teenage kids to get into the “right schools” is stressful and cruel. So please forgive me while I preach a little about the joy of children and grandchildren, because plenty of sensible people will tell you to do anything but commit to love first and to career, money and possessions second. And this isn’t only about heterosexual love. Everything I’m ranting about here is just as true for gay men and lesbian women who are in love and who want children and who like me also want to put their relationships ahead of stuff, prestige and ego. So I have news for us all: it’s the entire cycle of life that counts. And that cycle is the only real “biological clock” that matters. Everything else is just a footnote.

If you really listen, you find that most people tell you their life stories as soon as they meet you. Ariel, clearly, was another boring forty-year-old obsessed with her “biological clock.

To begin with, this world has a different kind of time. It is the time of biological rhythm, not of the clock and all that goes with the clock. There is no hurry. Our sense of time is notoriously subjective and thus dependent upon the quality of our attention, whether of interest or boredom, and upon the alignment of our behavior in terms of routines, goals, and deadlines. Here the present is self-sufficient, but it is not a static present. It is a dancing present, the unfolding of a pattern which has no specific destination in the future but is simply its own point. It leaves and arrives simultaneously, and the seed is as much the goal as the flower. There is therefore time to perceive every detail of the movement with infinitely greater richness of articulation. Normally we do not so much look at things as overlook them.” ― Alan W Watts

Life relies on digitally coded instructions, translating between sequence and structure (from nucleotides to proteins), with ribosomes reading, duplicating, and interpreting the sequences on the tape. But any resemblance ends with the different method of addressing by which the instructions are carried out. In a digital computer, the instructions are in the form of COMMAND (ADDRESS) where the address is an exact (either absolute or relative) memory location, a process that translates informally into “DO THIS with what you find HERE and go THERE with the result.” Everything depends not only on precise instructions, but also on HERE, THERE, and WHEN being exactly defined. In biology, the instructions say, “DO THIS with the next copy of THAT which comes along.” THAT is identified not by a numerical address defining a physical location, but by a molecular template that identifies a larger, complex molecule by some smaller, identifiable part. This is the reason that organisms are composed of microscopic (or near-microscopic) cells, since only by keeping all the components in close physical proximity will a stochastic, template-based addressing scheme work fast enough. There is no central address authority and no central clock. Many things can happen at once. This ability to take general, organized advantage of local, haphazard processes is the ability that (so far) has distinguished information processing in living organisms from information processing by digital computers.

The twenty-four-hour biological clock sitting in the middle of your brain is called the suprachiasmatic nucleus.

The twenty-four-hour biological clock sitting in the middle of your brain is called the suprachiasmatic (pronounced soo-pra-kai-as-MAT-ik) nucleus. As with much of anatomical language, the name, while far from easy to pronounce, is instructional: supra, meaning above, and chiasm, meaning a crossing point. The crossing point is that of the optic nerves coming from your eyeballs. Those nerves meet in the middle of your brain, and then effectively switch sides. The suprachiasmatic nucleus is located just above this intersection for a good reason. It “samples” the light signal being sent from each eye along the optic nerves as they head toward the back of the brain for visual processing. The suprachiasmatic nucleus uses this

Our children didn’t always go to school at this biologically unreasonable time. A century ago, schools in the US started at nine a.m. As a result, 95 percent of all children woke up without an alarm clock.

By now, you’re familiar with Horvath’s clock, a way to determine someone’s biological age. Horvath’s team discovered that menopause speeds up cellular aging by an average of 6 percent. The research and resulting arguments “very, very strongly suggest that the loss of hormones that accompanies menopause accelerates or increases biologic age,” said Horvath to Time in 2016.

Vitamin D3 boasts a strong safety profile, along with broad and deep evidence that links it to brain, metabolic, cardiovascular, muscle, bone, lung, and immune health. New and emerging research suggests that vitamin D supplements may also slow down our epigenetic/biological aging.29, 30 2. Omega-3 fish oil: Over the last thirty years or so, the typical Western diet has added more and more pro-inflammatory omega-6 polyunsaturated fatty acids versus anti-inflammatory omega-3 PUFAs. Over the same period, we’ve seen an associated rise in chronic inflammatory diseases, including obesity, cardiovascular disease, rheumatoid arthritis, and Alzheimer’s disease. 31 Rich in omega-3s, fish oil is another incredibly versatile nutraceutical tool with multi-pronged benefits from head to toe. By restoring a healthier PUFA ratio, it especially helps your brain and heart. Regular consumption of fatty fish like salmon has been linked to a lower risk of congestive heart failure, coronary heart disease, sudden cardiac death, and stroke.32 In an observational study, omega-3 fish oil supplementation was also associated with a slower biological clock.33 3. Magnesium deficiency affects more than 45 percent of the U.S. population. Supplements can help us maintain brain and cardiovascular health, normal blood pressure, and healthy blood sugar metabolism. They may also reduce inflammation and help activate our vitamin D. 4. Vitamin K1/K2 supports blood clotting, heart/ blood vessel health, and bone health.34 5. Choline supplements with brain bioavailability, such as CDP-Choline, citicoline, or alpha-GPC, can boost your body’s storehouse of the neurotransmitter acetylcholine and possibly support liver and brain function, while protecting it from age-related insults.35 6. Creatine: This one may surprise you, since it’s often associated with serious athletes and fitness buffs. But according to Dr. Lopez, it’s “a bona fide arrow in my longevity nutraceutical quiver for most individuals, and especially older adults.” As a coauthor of a 2017 paper by the International Society for Sports Nutrition, Dr. Lopez, along with contributors, stated that creatine not only enhances recovery, muscle mass, and strength in connection with exercise, but also protects against age-related muscle loss and various forms of brain injury.36 There’s even some evidence that creatine may boost our immune function and fat and carbohydrate metabolism. Generally well tolerated, creatine has a strong safety profile at a daily dose of three to five grams.37 7.

How biological can this clock really be, if it doesn't get you going until midnight?

Researchers say that 1 week camping without electronics resets our biological body clock and synchronizes our melatonin hormones with sunrise and sunset.

Maybe her current state was the simple matter of her biological clock kicking into gear, and Zeke just happened to be the closest appropriate male. She’d read about the biology of attraction, analyzed it. Men liked women with big breasts because that meant they could feed all the babies. Women, on a cellular level, went for a man who could take care of the saber-tooth tiger that was trying to get into their cave. When it came to simple genetics, Zeke was rather caveman like. He hadn’t yet grunted at her, but she was certain he would, sooner or later.

We can screw up our biological clocks a lot easier than that, too. Shift work, where employees alternate between days and nights on the job, leads to a significantly higher rate of violence, mood disorders, depression, and suicide. If a shift worker is scheduled even just one night on duty, urinary electrolytes take five days to adjust and eight days for the heart rate to return to normal. The World Health Organization has suggested that shift work is a “possible” carcinogen.

you had been in that capsule long enough, you’d eventually have felt hungry, thirsty, and tired. But those are markers of biological time. You still wouldn’t have known exactly how much time had elapsed according to the clock, because mechanical time is purely a human construct. Ancient

In the great urban centers, the pulse of the factory served as a kind of metronome for the city at large. In the urban workplace, where wages were paid by the hour, efficiency was a measure of success. Factory hands demonstrated their worth by completing the maximum number of standardized motions in a given period. After the factory whistle blew, their time was their own. But even at leisure, city dwellers saw time as a resource, like coal or copper. The fear that time might run out, as every resource will, left them with the dread of time wasted. On the farm, meanwhile, time was not something you stockpiled like firewood. Farm chores took as long as they took—there was no rushing an ear of corn—and the workday stretched to accommodate the tasks at hand. Time was elastic. The minutes and hours that mattered so much to city folk were irrelevant to the drawn-out biological processes on which the farmer depended. In place of the clock, the farmer’s yardstick for measuring time was the progress of the seasons. As a result, his view of time was expansive, focused on the sweeping cycles of the natural world. For city people, time was fractured into finite segments like boxes on a conveyer belt. On the farm, time was continuous, like a string around a tree, one season flowing inevitably into the next. For

To begin with, this world has a different kind of time. It is the time of biological rhythm, not of the clock and all that goes with the clock. There is no hurry. Our sense of time is notoriously subjective and thus dependent upon the quality of our attention, whether of interest or boredom, and upon the alignment of our behavior in terms of routines, goals, and deadlines. Here the present is self-sufficient, but it is not a static present. It is a dancing presentóthe unfolding of a pattern which has no specific destination in the future but is simply its own point. It leaves and arrives simultaneously, and the seed is as much the goal as the flower. There is therefore time to perceive every detail of the movement with infinitely greater richness of articulation. Normally we do not so much look at things as overlook them.

She leaned in and placed her hand reassuringly on mine. "And don't worry, dear," she said conspiratorially. "I know it will still happen for you. There's still time." There it was. ...But much to my surprise, I didn't need to lean on my collective self to navigate around this nice woman who thought she was providing me comfort by assuring me that, despite my age, I appeared to be someone to whom things could still happen...For a minute I felt all the old defense mechanisms go up, like metal toward a magnet. I took a deep breath and prepared to deliver my well-rehearsed responses...all the things I was used to saying to get out of this conversation and make the other person feel more comfortable. Instead, I found myself resisting the urge to laugh. Not at her. At the suddenly absurd idea that I was running out of time. I was no longer running, I realized. I was off the clock. "I have to tell you," I said, making sure there was not one ounce of defensiveness in my voice, "I think it's going to be pretty great even if it doesn't happen.

Crushes thrive in small spaces. Humans must be programmed to respond positively when faced with a small sampling of other humans in, say, caves. You’re stuck in a cave with three other people—all mankind, presumably, was hidden away in such tiny groups during the winters until the thaw—and so, in order for the species to thrive, you must biologically be compelled to fuck at least one person in your cave, despite the fact that, when surrounded by a plenitude of Neanderthals at the Neanderthal summer barbecue, none of them struck your fancy. Without the element of choice, and in conjunction with captivity, you find love, or at least you find lust.

The Skull Valley reservation is ringed by toxic and hazardous waste facilities (Figure 1). To the south lies the Dugway Proving Grounds, where the US Army tests chemical, biological, radiological, nuclear, and other weapons and trains elite members of the US armed forces in their use. To the west is the Utah Test and Training Range, a vast swath of desert the US Air Force uses for target practice by bombers, the testing of cruise missiles, and air-to-air combat training for fighter jets. North and west of the reservation a private company, Enviro Care, landfills 93 percent of the nation's Class A, low-level nuclear waste. East of the reservation sit the Tooele Army Depot, one of the largest weapons depots in the world, and the Deseret Chemical Depot, which until recently was home to nearly 50 percent of the nation's aging stockpile of chemical weapons. From 1996 to 2012 the US Army worked around the clock to incinerate over a million rockets, missiles, and mortars packed with sarin, mustard gas, and other deadly agents.

economic rationality is no match for a biological clock forged during a few million years of evolution. Even “sophisticated economic agents acting in real and highly incentivized settings are influenced by diurnal rhythms in the performance of their professional duties.”10 These findings have wide implications, say the researchers. The results “are indicative of a much more pervasive phenomenon of diurnal rhythms influencing corporate communications, decision-making and performance across all employee ranks and business enterprises throughout the economy.