Biochem Quotes

It is possible to cause seemingly biochemical changes through human emotional involvement. You literally have changed his chemistry by being his friend.

The muscles used to make a smile actually send a biochemical message to our nervous system that it is safe to relax the flight of freeze response.

all addictions—whether to drugs or to non-drug behaviors—share the same brain circuits and brain chemicals. On the biochemical level the purpose of all addictions is to create an altered physiological state in the brain. This can be achieved in many ways, drug taking being the most direct. So an addiction is never purely “psychological”; all addictions have a biological dimension.

In the abstract, it might be tempting to imagine that irreducible complexity simply requires multiple simultaneous mutations - that evolution might be far chancier than we thought, but still possible. Such an appeal to brute luck can never be refuted... Luck is metaphysical speculation; scientific explanations invoke causes.

The conclusion of intelligent design flows naturally from the data itself—not from sacred books or sectarian beliefs. Inferring that biochemical systems were designed by an intelligent agent is a humdrum process that requires no new principles of logic or science. It comes simply from the hard work that biochemistry has done over the past forty years, combined with consideration of the way in which we reach conclusions of design every day.

Emotions are the lowest form of consciousness. Emotional actions are the most contracted, narrowing, dangerous form of behavior. The romantic poetry and fiction of the last 200 years has quite blinded us to the fact that emotions are an active and harmful form of stupor. Any peasant can tell you that. Beware of emotions. Any child can tell you that. Watch out for the emotional person. He is a lurching lunatic. Emotions are caused by biochemical secretions in the body to serve during the state of acute emergency. An emotional person is a blind, crazed maniac. Emotions are addictive and narcotic and stupefacient. Do not trust anyone who comes on emotional. What are the emotions? In a book entitled Interpersonal Diagnosis of Personality, written when I was a psychologist, I presented classifications of emotions and detailed descriptions of their moderate and extreme manifestations. Emotions are all based on fear. [...] The emotional person cannot think; he cannot perform any effective game action (except in acts of physical aggression and strength). The emotional person is turned off sensually. His body is a churning robot. [...] The only state in which we can learn, harmonize, grow, merge, join, understand is the absence of emotion. This is called bliss or ecstasy, attained through centering the emotions. [...] Conscious love is not an emotion; it is serene merging with yourself, with other people, with other forms of energy. Love cannot exist in an emotional state. [...] The great kick of the mystic experience, the exultant, ecstatic hit, is the sudden relief from emotional pressure. Did you imagine that there could be emotions in heaven? Emotions are closely tied to ego games. Check your emotions at the door to paradise.

What some people hope to get by studying, working or raising a family, others try to obtain far more easily through the right dosage of molecules. This is an existential threat to the social and economic order, which is why countries wage a stubborn, bloody and hopeless war on biochemical crime.

Genes are biochemical recipes written in a four-letter alphabet called DNA.

This is all the fault of evolution. For countless generations our biochemical system adapted to increasing our chances of survival and reproduction, not our happiness. The

Sixty-some years ago, biochemical organisms began to assemble digital computers. Now digital computers are beginning to assemble biochemical organisms. Viewed from a distance, this looks like part of a life cycle. But which part? Are biochemical organisms the larval phase of digital computers? Or are digital computers the larval phase of biochemical organisms?

There is evidence that the honoree [Leonard Cohen] might be privy to the secret of the universe, which, in case you're wondering, is simply this: everything is connected. Everything. Many, if not most, of the links are difficult to determine. The instrument, the apparatus, the focused ray that can uncover and illuminate those connections is language. And just as a sudden infatuation often will light up a person's biochemical atmosphere more pyrotechnically than any deep, abiding attachment, so an unlikely, unexpected burst of linguistic imagination will usually reveal greater truths than the most exacting scholarship. In fact. The poetic image may be the only device remotely capable of dissecting romantic passion, let alone disclosing the inherent mystical qualities of the material world. Cohen is a master of the quasi-surrealistic phrase, of the "illogical" line that speaks so directly to the unconscious that surface ambiguity is transformed into ultimate, if fleeting, comprehension: comprehension of the bewitching nuances of sex and bewildering assaults of culture. Undoubtedly, it is to his lyrical mastery that his prestigious colleagues now pay tribute. Yet, there may be something else. As various, as distinct, as rewarding as each of their expressions are, there can still be heard in their individual interpretations the distant echo of Cohen's own voice, for it is his singing voice as well as his writing pen that has spawned these songs. It is a voice raked by the claws of Cupid, a voice rubbed raw by the philosopher's stone. A voice marinated in kirschwasser, sulfur, deer musk and snow; bandaged with sackcloth from a ruined monastery; warmed by the embers left down near the river after the gypsies have gone. It is a penitent's voice, a rabbinical voice, a crust of unleavened vocal toasts -- spread with smoke and subversive wit. He has a voice like a carpet in an old hotel, like a bad itch on the hunchback of love. It is a voice meant for pronouncing the names of women -- and cataloging their sometimes hazardous charms. Nobody can say the word "naked" as nakedly as Cohen. He makes us see the markings where the pantyhose have been. Finally, the actual persona of their creator may be said to haunt these songs, although details of his private lifestyle can be only surmised. A decade ago, a teacher who called himself Shree Bhagwan Rajneesh came up with the name "Zorba the Buddha" to describe the ideal modern man: A contemplative man who maintains a strict devotional bond with cosmic energies, yet is completely at home in the physical realm. Such a man knows the value of the dharma and the value of the deutschmark, knows how much to tip a waiter in a Paris nightclub and how many times to bow in a Kyoto shrine, a man who can do business when business is necessary, allow his mind to enter a pine cone, or dance in wild abandon if moved by the tune. Refusing to shun beauty, this Zorba the Buddha finds in ripe pleasures not a contradiction but an affirmation of the spiritual self. Doesn't he sound a lot like Leonard Cohen? We have been led to picture Cohen spending his mornings meditating in Armani suits, his afternoons wrestling the muse, his evenings sitting in cafes were he eats, drinks and speaks soulfully but flirtatiously with the pretty larks of the street. Quite possibly this is a distorted portrait. The apocryphal, however, has a special kind of truth. It doesn't really matter. What matters here is that after thirty years, L. Cohen is holding court in the lobby of the whirlwind, and that giants have gathered to pay him homage. To him -- and to us -- they bring the offerings they have hammered from his iron, his lead, his nitrogen, his gold.

It is one of the striking generalizations of biochemistry—which surprisingly is hardly ever mentioned in the biochemical text-books—that the twenty amino acids and the four bases, are, with minor reservations, the same throughout Nature. As far as I am aware the presently accepted set of twenty amino acids was first drawn up by Watson and myself in the summer of 1953 in response to a letter of Gamow's.

By equating the human experience with data patterns, Dataism undermines our main source of authority and meaning, and heralds a tremendous religious revolution, the like of which has not been seen since the eighteenth century. In the days of Locke, Hume and Voltaire humanists argued that ‘God is a product of the human imagination’. Dataism now gives humanists a taste of their own medicine, and tells them: ‘Yes, God is a product of the human imagination, but human imagination in turn is the product of biochemical algorithms.’ In the eighteenth century, humanism sidelined God by shifting from a deo-centric to a homo-centric world view. In the twenty-first century, Dataism may sideline humans by shifting from a homo-centric to a data-centric view. The

The fetus is biochemically connected to the mother, and her external, internal, physical, and mental health affect the overall development of the fetus. Stress and depression during pregnancy have been proven to have long-term and even permanent effects on the offspring. Such effects include a vulnerability to chronic anxiety, elevated fear, propensity to addictions, and poor impulse control.

When you're the sane brother of a schizophrenic identical twin, the tricky thing about saving yourself is the blood it leaves on your hands--the little inconvenience of the look-alike corpse at your feet. And if you're into both survival of the fittest and being your brother's keeper--if you've promised your dying mother--then say so long to sleep and hello to the middle of the night. Grab a book or a beer. Get used to Letterman's gap-toothed smile of the absurd, or the view of the bedroom ceiling, or the indifference of random selection. Take it from a godless insomniac. Take it from the uncrazy twin--the guy who beat the biochemical rap.

AT ANOTHER LOCATION, WE FOUND BARRELS OF CHEMICAL material that was intended for use as biochemical weapons. Everyone talks about there being no weapons of mass destruction in Iraq, but they seem to be referring to completed nuclear bombs, not the many deadly chemical weapons or precursors that Saddam had stockpiled. Maybe the reason is that the writing on the barrels showed that the chemicals came from France and Germany, our supposed Western allies.

Losing a belief in free will has not made me a fatalist - in fact, it has increased my feelings of freedom. My hopes, fears, and neuroses seem less personal and indelible. There is no telling how much I might change in the future. Just as one wouldn't draw a lasting conclusion about oneself on the basis of a brief experience of indigestion, one needn't do so on a basis of how one has thought or behaved for vast stretches of time in the past. A creative change of inputs to the system - learning new skills, forming new relationships, adopting new habits of attention - may radically transform one's life. Becoming sensitive to the background causes of one's thoughts and feelings can -paradoxically- allow for greater creative control over one's life. This understanding reveals you to be a biochemical puppet, of course, but it also allows you to grab hold of one of your strings.

Depression and anxiety are two of the body’s first reactions to stockpiles of hurt. Of course, there are organic and biochemical reasons we experience clinical depression and debilitating anxiety—causes over which we have no control—but unrecognized pain and unprocessed hurt can also lead there.

Social psychologist argued that even severe mental illness was the result of society labeling unusual behavior rather than of biochemical processes.

Creatures with poorly self-regulated stress reactions will be more anxious, less capable of confronting ordinary environmental challenges, and overstressed even under normal circumstances. The study showed the quality of early maternal care to have a causal impact on the offspring’s brains’ biochemical capacity to respond to stress in a healthy way into adulthood. Key

The result of these cumulative efforts to investigate the cell—to investigate life at the molecular level—is a loud, clear, piercing cry of “design!” The result is so unambiguous and so significant that it must be ranked as one of the greatest achievements in the history of science. The discovery rivals those of Newton and Einstein, Lavoisier and Schrödinger, Pasteur, and Darwin.

When trying to understand the interactions of nonhuman organisms, it is easy to flip between these two perspectives: that of the inanimate behavior of preprogrammed robots on the one hand, and that of rich, lived human experience on the other. Framed as brainless organisms, lacking the basic apparatus required to have even a simple kind of “experience,” fungal interactions are no more than automatic responses to a series of biochemical triggers. Yet the mycelium of truffle fungi, like that of most fungal species, actively senses and responds to its surroundings in unpredictable ways.

Did I need medication? Or did I need someone to talk to? Someone, that is, who would do more than charge the going rate for nodding and whip out a prescription pad before the first fifty minutes were up. Was I physiologically depressed? At an innate biochemical disadvantage? Or was reaching for the pad just the way things were done because the doc had been well patronized by the drug reps and had plenty of samples in her file cabinet?

Politicians are a bit like musicians, and the instrument they play on is the human emotional and biochemical system. They give a speech, and there is a wave of fear in the country. They tweet, and there is an explosion of hatred.

Thich Nhat Hanh calls his practice of yes “smile yoga.” He suggests bringing a slight but real smile to our lips many times throughout the day, whether we are meditating or simply stopping for a red light. “A tiny bud of a smile on your lips,” writes Thich Nhat Hanh, “nourishes awareness and calms you miraculously … your smile will bring happiness to you and to those around you.” The power of a smile to open and relax us is confirmed by modern science. The muscles used to make a smile actually send a biochemical message to our nervous system that it is safe to relax the flight, fight or freeze response. A smile is the yes of unconditional friendliness that welcomes experience without fear.

The essential point of view advanced here is this: the stability of every living being, as of every structurally stable form, rests, in the last analysis, on a for- mal structure—in fact, a geometrical object—whose biochemical realization is the living being.

And I'll go even further and say that mathematics, this art of abstract pattern-making — even more than storytelling, painting, or music - is our most quintessentially human art form. This is what our brains do, whether we like it or not. We are biochemical pattern-recognition machines and mathematics is nothing less than the distilled essence of who we are.

what distinguishes us from non-human organisms is that we do not simply react to biochemical impulses; we can transcend them by choosing to interpret them in particular ways.

most up-to-date theories also maintain that sensations and emotions are biochemical data-processing algorithms.

At each step biochemical triggers and feedbacks determine which of the alternative developmental pathways among several possibles a group of cells will actually follow.

Running is a form of practiced stoicism. It means teaching your brain and body to be biochemically comfortable in a state of disrepair.

I have to laugh when people ask me if I do alternative, herbal, acupuncture or holistic medicine. 'No,' I reply. 'We do state-of-the-art medicine. In other words, we find the biochemical, nutritional and environmental causes and cures rather than blindly drugging everything. Sure, herbs are gentler, safer and more physiologic than drugs and holistic medicine attempts to incorporate many diverse modalities, etc. But there is no substitute for finding the underlying biochemical causes and cures. This is real medicine. This is where medicine should and would have been decades ago, if it had not been abducted by the pharmaceutical industry.

There are no detailed Darwinian accounts for the evolution of any fundamental biochemical or cellular system, only a variety of wishful speculations [Article : "In the Details . . . What?"]

Bear in mind that since medications do not fix anything, they allow the underlying problem to continue uncorrected and actually accelerate. Meanwhile, new symptoms and new seemingly unrelated diseases are the inevitable consequence of this biochemical faux pas. Furthermore, drug side effects are the leading cause of death. NSAIDs as an example of only one group of medications, are fatally toxic to thousands of people each year by damaging joints, lungs, kidneys, eyes, hearts, and intestines. And they are covered by insurance. You and your doctor have been screwed into believing every symptom is a deficiency of some drug or surgery. You've been led to believe you have no control, when in truth you're the one who must take control. Unfortunately, the modus operandi in medicine is to find a drug to turn off the damaged part that is producing symptoms.

While conversion of sugars to ethanol is the predominant reaction, it is only one of potentially thousands of biochemical reactions taking place during fermentation. As a result, wine contains trace amounts of a large number of organic acids, esters, sugars, alcohols, and other molecules. Wine is, in fact, one of the most complex of all beverages: the fruit of a soil, climate, and vintage, digested by a fungus through a process guided by the culture, vision, and skill of an individual man or woman.

the mind with the brain, but they are really very different things. The brain is a material network of neurons, synapses, and biochemicals. The mind is a flow of subjective experiences, such as pain, pleasure, anger, and love. Biologists assume that the brain somehow produces

Even if we accept the view that biochemical imbalances may contribute to depression and suicide, it is a mistake to assume that the biochemical aspect of the problem is entirely within the victim. It is also partly within the physiological makeup of the people around the suicide.

I feel you're far away,” the man might say. He is observing you, calculating, forming equations he may take to a representative of the patriarchy, such as a doctor, a lawyer, or military official. He is considering physical incarceration and/or biochemical imprisonments such as occur with antidepressants. He is dangerous. This is a juncture where you may smile. This is optional. You might allow your lips to form the ambiguous seductive shape of slow regret. Or let your mouth fill with too much night, incinerated maple leaves and fox teeth. What you mean is, not yet.

Classifying depression as an illness serves the psychiatric community and pharmaceutical corporations well; it also soothes the frightened, guilty, indifferent, busy, sadistic, and unschooled. To understand depression as a call for life-changes is not profitable. Stagnation is not a medical term. The 17.5 million Americans diagnosed as suffering a major depression in 1997 were mostly damned. (Psychobiological examinations confuse cause and symptom.) Deficient serotonergic functioning, ventral prefrontal cerebral cortex, dis-inhibition of impulsive-aggressive behavior, blah blah blah: the medical lexicon boils emotion from human being. Go take a drug, the doctor says. Pain is a biochemical phenomenon. Erase all memory.

Adrenaline poisoning,’ one of my doctors had called these surges of anxiety that had troubled me since childhood. The doctors explained that, for reasons they could not understand, my body seemed to think it was in a constant state of danger. One of the specialists my aunt consulted explained earnestly that it was a biochemical leftover from hunter-gatherer days. I’d be all right so long as I rid my bloodstream of the adrenaline load

Now that our marriage is over, I know what love is. It's a trick on the brain, the adrenal glands releasing endorphins. It floods the cells that transmit worry and better sense, drowns them with biochemical bliss. You can know all these things about love, yet it remains irresistible, as beguiling as the floating arms of long sleep.

Some scientists thrive on the conceptual; their minds can envision particles that the most powerful microscopes can’t show us; processes that can’t be directly observed, but only inferred, guessed at, by interpreting a stew of complex biochemical by-products. I am not one of these scientists; I need bones and teeth, things I can see with my eyes and grasp with my hands. Jason Eshleman, on the other hand, can see with his mind’s eye, grasping the complex interactions of the most complex molecules in the body, DNA.

The recent recognition that the genetic code possesses a unique capacity to resist errors caused by mutation imparts the biochemical intelligent design argument with an entirely new level of credibility. Like a giant SOS shaped with letters ablaze, the optimal nature of the genetic code signals that an Intelligent Agent used those rules to start and sustain life.

Mind, in the way I use the word, is not just thought. It includes your emotions as well as all unconscious mental-emotional reactive patterns. Emotion arises at the place where mind and body meet. It is the body’s reaction to your mind — or you might say, a reflection of your mind in the body. For example, an attack thought or a hostile thought will create a buildup of energy in the body that we call anger. The body is getting ready to fight. The thought that you are being threatened, physically or psychologically, causes the body to contract, and this is the physical side of what we call fear. Research has shown that strong emotions even cause changes in the biochemistry of the body. These biochemical changes represent the physical or material aspect of the emotion. Of course, you are not usually conscious of all your thought patterns, and it is often only through watching your emotions that you can bring them into awareness.

[In reference to cases of testicular feminization]: “The incredible lesson about our sexual biology is that all men at one point in their fetal development have the capacity to be women. Moreover the body is programmed to develop as a female unless it sees and recognizes specific biochemical signals such as testosterone and anti-mullerian factor that tell it to develop as a male.

Even the poorest and most squalid life is an Aeschylean drama, if you think about the tragedy of the bodily functions, the whispering of the secretions, the silence of the organs, the exertions of memory, the groping of the voice, the blood that courses, the mortal miasmas, the riots among microorganisms, the spermatic wars, the cellular eruptions, the pestilences of the nerves, the biochemical predestinations, and the fate that slowly but surely introduces you to the final infection, to the sores, the exploded boils, the snakes of madness, the furious bitches of Hunger.

AI will have to analyze human feelings accurately in order to treat human illnesses, identify human terrorists, recommend human mates, and navigate a street full of human pedestrians. But it could do so without having any feelings of its own. An algorithm does not need to feel joy, anger, or fear in order to recognize the different biochemical patterns of joyful, angry, or frightened apes.

I find it hard to understand the mind of the true atheist, who believes that life is nothing more than a series of electrical impulses and biochemical reactions to chemical stimuli. Presumably, such thinkers see death as the worst thing that can occur, because it means the end of everything. Therefore (logically), maintaining the continuance of physical existence, under any circumstances, is entirely justifiable.

Furthermore, because silicon packs on more protons than carbon, it's bulkier, like carbon with fifty extra pounds. Sometimes that's not a big deal. Silicon might substitute adequately for carbon in the Martian equivalent of fats or proteins. But carbon also contorts itself into ringed molecules we call sugars. Rings are states of high-tension- which means they store lots of energy-and silicon just isn't supple enough to bend into the right position to form rings. In a related problem, silicon atoms cannot squeeze their electrons into tight spaces for double bonds, which appear in virtually every complicated biochemical.

Becoming sensitive to the background causes of one's thoughts and feelings can—paradoxically—allow for greater creative control over one's life. It is one thing to bicker with your wife because you are in a bad mood; it is another to realize that your mood and behavior have been caused by low blood sugar. This understanding reveals you to be a biochemical puppet, of course, but it also allows you to grab hold of one of your strings: A bit of food may be all that your personality requires. Getting behind our concious thoughts and feelings can allow us to steer a more intelligent course through our lives (while knowing, of course, that we are ultimately being steered).

Our tree’s only source of energy is the sun: after light photons stimulate the pigments within the leaf, buzzing electrons line up into an unfathomably long chain and pass their excitement one to the other, moving biochemical energy across the cell to the exact location where it is needed. The plant pigment chlorophyll is a large molecule, and within the bowl of its spoon-shaped structure sits one single precious magnesium atom. The amount of magnesium needed for enough chlorophyll to fuel thirty-five pounds of leaves is equivalent to the amount of magnesium found in fourteen One A Day vitamins, and it must ultimately dissolve out of bedrock, which is a geologically slow process.

Work ethic is not a moral virtue that can be cultivated simply by wanting to be a better person. It’s actually a biochemical condition that can be fostered, purposefully, through activity that increases dopamine levels in the brain.

If these biochemical phenomena sound similar to those of the fight-or-flight syndrome, they are, except that here we are running toward something or someone; indeed, a cynic might say toward rather than away from danger. The changes are also fully consistent with those of the early phases of addictive behavior. The Roxy Music song “Love Is the Drug” is quite accurate in describing this state (albeit the subject of the song is looking to score his next fix of love).

Throughout the human life span there remains a constant two-way interaction between psychological states and the neurochemistry of the frontal lobes, a fact that many doctors do not pay enough attention to. One result is the overreliance on medications in the treatment of mental disorders. Modern psychiatry is doing too much listening to Prozac and not enough listening to human beings; people’s life histories should be given at least as much importance as the chemistry of their brains. The dominant tendency is to explain mental conditions by deficiencies of the brain’s chemical messengers, the neurotransmitters. As Daniel J. Siegel has sharply remarked, “We hear it said everywhere these days that the experience of human beings comes from their chemicals.” Depression, according to the simple biochemical model, is due to a lack of serotonin — and, it is said, so is excessive aggression. The answer is Prozac, which increases serotonin levels in the brain. Attention deficit is thought to be due in part to an undersupply of dopamine, one of the brain’s most important neurotransmitters, crucial to attention and to experiencing reward states. The answer is Ritalin. Just as Prozac elevates serotonin levels, Ritalin or other psychostimulants are thought to increase the availability of dopamine in the brain’s prefrontal areas. This is believed to increase motivation and attention by improving the functioning of areas in the prefrontal cortex. Although they carry some truth, such biochemical explanations of complex mental states are dangerous oversimplifications — as the neurologist Antonio Damasio cautions: "When it comes to explaining behavior and mind, it is not enough to mention neurochemistry... The problem is that it is not the absence or low amount of serotonin per se that “causes” certain manifestations. Serotonin is part of an exceedingly complicated mechanism which operates at the level of molecules, synapses, local circuits, and systems, and in which sociocultural factors, past and present, also intervene powerfully. The deficiencies and imbalances of brain chemicals are as much effect as cause. They are greatly influenced by emotional experiences. Some experiences deplete the supply of neurotransmitters; other experiences enhance them. In turn, the availability — or lack of availability — of brain chemicals can promote certain behaviors and emotional responses and inhibit others. Once more we see that the relationship between behavior and biology is not a one-way street.

The bodies state of red alert brings about a series of psychological changes, driven by gathering tides of adrenaline or cortisol. These are the fight or flight hormones, which act to help and organism respond to external stresses. But when a stress is chronic not acute, when it persists for years and is caused by something that cannot be outrun, then these biochemical alterations wreak havoc on the body. Lonely people are restless sleepers and experience a reduction in the restorative function of sleep. Loneliness drives up blood pressure, accelerates ageing, weakens the immune system and acts as a precursor to cognitive decline. According to a 2010 study, "Loneliness predicts increased morbidity and mortality". Which is an elegant way of saying that loneliness can prove fatal.

many abuse victims don’t wish to let their abusers move onto the next victim after terrorizing them, because they fear that the next person might be treated better, thereby confirming their own sense of worthlessness that was instilled by the abuser in the first place. They may also have an unending sense of needing a real “apology” or seeing karma at work before they feel they can truly let go.

Catharsis comes when Joy understands her mistake and she—along with the viewers—realizes that Riley isn’t Joy, or Sadness, or any of the other characters. Riley is a complex story produced by the conflicts and collaborations of all the biochemical characters together.

The problem is a survivor never knows when the next warm and fuzzy experience will happen, or when the next episode of abuse is coming through the door. Intermittent reinforcement is a powerful emotional string abusers like to pull. Never knowing what will happen next can be intoxicating for a survivor who is not fully aware of the game being played. Intermittent reinforcement causes adrenaline rushes in the body and stress hormones to be produced. It creates a biochemical shift in the survivor that becomes addicting and from which is hard to break free.

This Buddhist view of happiness has a lot in common with the biochemical view. Both agree that pleasant sensations disappear as fast as they arise, and that as long as people crave pleasant sensations without actually experiencing them, they remain dissatisfied. However, this problem has two very different solutions. The biochemical solution is to develop products and treatments that will provide humans with an unending stream of pleasant sensations, so we will never be without them. The Buddha’s suggestion was to reduce our craving for pleasant sensations, and not allow them to control our lives. According to Buddha, we can train our minds to observe carefully how all sensations constantly arise and pass. When the mind learns to see our sensations for what they are – ephemeral and meaningless vibrations – we lose interest in pursuing them. For

there is a hidden intelligence embedded in the female fertility cycle: an ancient knowledge that women can use to make the best decisions in their modern lives. Behind the everyday behavior that some interpret as simply “hormonal,” there is a biochemical process that has helped females—billions across thousands of species—choose mates, avoid rape, compete with female rivals, fight for resources, and produce offspring with fit genes and good prospects. To master these challenges, female brains evolved to conspire with their hormones rather than be corrupted by them.

Dataism adopts a strictly functional approach to humanity, appraising the value of human experiences according to their function in data-processing mechanisms. If we develop an algorithm that fulfils the same function better, human experiences will lose their value. Thus if we can replace not just taxi drivers and doctors but also lawyers, poets and musicians with superior computer programs, why should we care if these programs have no consciousness and no subjective experiences? If some humanist starts adulating the sacredness of human experience, Dataists would dismiss such sentimental humbug. ‘The experience you praise is just an outdated biochemical algorithm. In the African savannah 70,000 years ago, that algorithm was state-of-the-art. Even in the twentieth century it was vital for the army and for the economy. But soon we will have much better algorithms.

In the days of Locke, Hume and Voltaire humanists argued that ‘God is a product of the human imagination’. Dataism now gives humanists a taste of their own medicine, and tells them: ‘Yes, God is a product of the human imagination, but human imagination in turn is just the product of biochemical

babies’ brains build the neural pathways to soothe their upsets every time you soothe them.9 Simply by comforting your baby or toddler when she’s upset, you prompt her body to release calming biochemicals and strengthen her future ability to soothe herself—the most fundamental emotional intelligence skill.

The zoologists who came from Germany to inseminate the elephant wore bicycle helmets and protective rubber suits. So as not to be soiled by effluvium and excrement, which will alchemize to produce laughter in the human species, how does that work biochemically is a question to which I have not found an answer yet.

Science finds it hard to decipher the mysteries of the mind largely because we lack efficient tools. Many people, including many scientists, tend to confuse the mind with the brain, but they are really very different things. The brain is a material network of neurons, synapses, and biochemicals. The mind is a flow of subjective experiences, such as pain, pleasure, anger, and love. Biologists assume that the brain somehow produces the mind and that biochemical reactions in billions of neurons somehow produce experiences such as pain and love. However, so far we have absolutely no explanation for how the mind emerges from the brain.

There are simply several different paths leading to high intelligence, and only some of these paths involve gaining consciousness. Just as airplanes fly faster than birds without ever developing feathers, so computers may come to solve problems much better than mammals without ever developing feelings. True, AI will have to analyse human feelings accurately in order to treat human illnesses, identify human terrorists, recommend human mates and navigate a street full of human pedestrians. But it could do so without having any feelings of its own. An algorithm does not need to feel joy, anger or fear in order to recognise the different biochemical patterns of joyful, angry or frightened apes.

What have you loved? What stands out in your mind as can’t miss Life Attractions?” “I’m not sure. When people make those bucket lists online, they focus on big, flashy things, like going to the top of the Eiffel Tower or swimming with dolphins or whatever. They’re doing those for Instagram, though, or because they think it’s what they’re supposed to want. I guess they do sound impressive when you say them out loud to other people. But everything I remember as being the best moments of my life has been so…small. Like…running through the sprinklers with my best friend on summer break, getting grass stuck all over my wet feet. The first time my baby sister smiled at a silly face I made. My first real Eureka moment in the biochem lab.

For me the only way total calories consumed matter in terms of weight management are their total contribution to fattening biochemical reactions from different foodstuffs. In other words it does matter how many calories of bread or meat you eat as 100 calories will have a smaller biochemical effect than 1,000 calories of both foods. Biochemistry leads and physics follows.

Some air-conditioning systems are set at 70 degrees Fahrenheit. Others are set at twenty degrees. Human happiness conditioning systems also differ from person to person. On a scale from one to ten, some people are born with a cheerful biochemical system that allows their mood to swing between levels six and ten, stabilising with time at eight. Such a person is quite happy even if she lives in an alienating big city, loses all her money in a stock-exchange crash and is diagnosed with diabetes. Other people are cursed with a gloomy biochemistry that swings between three and seven and stabilises at five. Such an unhappy person remains depressed even if she enjoys the support of a tight-knit community, wins millions in the lottery and is as healthy as an Olympic athlete.

We now know that early stress and adversity can literally get under a child’s skin, where it can cause damage that lasts a lifetime. But there is also some positive news in this research. It turns out that there is a particularly effective antidote to the ill effects of early stress, and it comes not from pharmaceutical companies or early-childhood educators but from parents. Parents and other caregivers who are able to form close, nurturing relationships with their children can foster resilience in them that protects them from many of the worst effects of a harsh early environment. This message can sound a bit warm and fuzzy, but it is rooted in cold, hard science. The effect of good parenting is not just emotional or psychological, the neuroscientists say; it is biochemical.

Parents and other caregivers who are able to form close, nurturing relationships with their children can foster resilience in them that protects them from many of the worst effects of a harsh early environment. This message can sound a bit warm and fuzzy, but it is rooted in cold, hard science. The effect of good parenting is not just emotional or psychological, the neuroscientists say; it is biochemical.

Biologists hold that our mental and emotional world is governed by biochemical mechanisms shaped by millions of years of evolution. Like all other mental states, our subjective well-being is not determined by external parameters such as salary, social relations or political rights. Rather, it is determined by a complex system of nerves, neurons, synapses and various biochemical substances such as serotonin, dopamine and oxytocin.

Twin, family, and population studies have all conclusively shown that psychological traits are at least partly, and sometimes largely, heritable—that is, a sizable portion of the variation that we see in these traits across the population is attributable to genetic variation. However, as we have seen in the preceding chapters, the relationship between genes and traits is far from simple. The fact that a given trait is heritable seems to suggest that there must be genes for that trait. But phrasing it in that way is a serious conceptual trap. It implies that genes exist that are dedicated to that function—that there are genes for intelligence or sociability or visual perception. But this risks confusing the two meanings of the word gene: one, from the study of heredity, refers to genetic variants that affect a trait; the other, from molecular biology, refers to the stretches of DNA that encode proteins with various biochemical or cellular functions.

Science finds it hard to decipher the mysteries of the mind largely because we lack efficient tools. Many people, including many scientists, tend to confuse the mind with the brain, but they are really very different things. The brain is a material network of neurons, synapses and biochemicals. The mind is a flow of subjective experiences, such as pain, pleasure, anger and love. Biologists assume that the brain somehow produces the mind, and that biochemical reactions in billions of neurons somehow produce experiences such as pain and love. However, so far we have absolutely no explanation for how the mind emerges from the brain. How come when billions of neurons are firing electrical signals in a particular pattern, I feel pain, and when the neurons fire in a different pattern, I feel love? We haven’t got a clue. Hence even if the mind indeed emerges from the brain, at least for now studying the mind is a different undertaking than studying the brain.

The three conditions without which healthy growth does not take place can be taken for granted in the matrix of the womb: nutrition, a physically secure environment and the unbroken relationship with a safe, ever-present maternal organism. The word matrix is derived from the Latin for “womb,” itself derived from the word for “mother.” The womb is mother, and in many respects the mother remains the womb, even following birth. In the womb environment, no action or reaction on the developing infant’s part is required for the provision of any of his needs. Life in the womb is surely the prototype of life in the Garden of Eden where nothing can possibly be lacking, nothing has to be worked for. If there is no consciousness — we have not yet eaten of the Tree of Knowledge — there is also no deprivation or anxiety. Except in conditions of extreme poverty unusual in the industrialized world, although not unknown, the nutritional needs and shelter requirements of infants are more or less satisfied. The third prime requirement, a secure, safe and not overly stressed emotional atmosphere, is the one most likely to be disrupted in Western societies. The human infant lacks the capacity to follow or cling to the parent soon after being born, and is neurologically and biochemically underdeveloped in many other ways. The first nine months or so of extrauterine life seem to have been intended by nature as the second part of gestation. The anthropologist Ashley Montagu has called this phase exterogestation, gestation outside the maternal body. During this period, the security of the womb must be provided by the parenting environment. To allow for the maturation of the brain and nervous system that in other species occurs in the uterus, the attachment that was until birth directly physical now needs to be continued on both physical and emotional levels. Physically and psychologically, the parenting environment must contain and hold the infant as securely as she was held in the womb. For the second nine months of gestation, nature does provide a near-substitute for the direct umbilical connection: breast-feeding. Apart from its irreplaceable nutritional value and the immune protection it gives the infant, breast-feeding serves as a transitional stage from unbroken physical attachment to complete separation from the mother’s body. Now outside the matrix of the womb, the infant is nevertheless held close to the warmth of the maternal body from which nourishment continues to flow. Breast-feeding also deepens the mother’s feeling of connectedness to the baby, enhancing the emotionally symbiotic bonding relationship. No doubt the decline of breast-feeding, particularly accelerated in North America, has contributed to the emotional insecurities so prevalent in industrialized countries. Even more than breast-feeding, healthy brain development requires emotional security and warmth in the infant’s environment. This security is more than the love and best possible intentions of the parents. It depends also on a less controllable variable: their freedom from stresses that can undermine their psychological equilibrium. A calm and consistent emotional milieu throughout infancy is an essential requirement for the wiring of the neurophysiological circuits of self-regulation. When interfered with, as it often is in our society, brain development is adversely affected.

The result will not be an Orwellian police state. We always prepare ourselves for the previous enemy, even when we face an altogether new menace. Defenders of human individuality stand guard against the tyranny of the collective, without realising that human individuality is now threatened from the opposite direction. The individual will not be crushed by Big Brother; it will disintegrate from within. Today corporations and governments pay homage to my individuality, and promise to provide medicine, education and entertainment customised to my unique needs and wishes. But in order to so, corporations and governments first need to break me up into biochemical subsystems, monitor these subsystems with ubiquitous sensors and decipher their working with powerful algorithms. In the process, the individual will transpire to be nothing but a religious fantasy. Reality will be a mesh of biochemical and electronic algorithms, without clear borders, and without individual hubs.

Just consider the next thought that pops up in your mind. Where did it come from? Did you freely choose to think it, and only then did you think it? Certainly not. The process of self-exploration begins with simple things, and becomes progressively harder. At first, we realise that we do not control the world outside us. I don’t decide when it rains. Then we realise that we do not control what’s happening inside our own body. I don’t control my blood pressure. Next, we understand that we don’t even govern our brain. I don’t tell the neurons when to fire. Ultimately we should realise that we do not control our desires, or even our reactions to these desires. Realising this can help us become less obsessive about our opinions, about our feelings, and about our desires. We don’t have free will, but we can be a bit more free from the tyranny of our will. Humans usually give so much importance to their desires that they try to control and shape the entire world according to these desires. In pursuit of their cravings, humans fly to the moon, wage world wars, and destabilise the entire ecosystem. If we understand that our desires are not the magical manifestations of free choice, but rather are the product of biochemical processes (influenced by cultural factors that are also beyond our control), we might be less preoccupied with them. It is better to understand ourselves, our minds and our desires rather than try to realise whatever fantasy pops up in our heads.

Along with unemployment neurosis, which is triggered by an individual's socioeconomic situation, there are other types of depression which are traceable back to psychodynamic or biochemical conditions, whichever the case may be. Accordingly, psychotherapy and pharmacotherapy are indicated respectively. Insofar as the feeling of meaninglessness is concerned, however, we should not overlook and forget that, per se, it is not a matter of pathology; rather than being the sign and symptom of a neurosis, it is, I would say, the proof of one's humanness. But although it is not caused by anything pathological, it may well cause a pathological reaction; in other words, it is potentially pathogenic. Just consider the mass neurotic syndrome so pervasive in the young generation: there is ample empirical evidence that the three facets of this syndrome - depression, aggression, addiction - are due to what is called in logotherapy "the existential vacuum," a feeling of emptiness and meaninglessness.

The only way to escape this fate was to mate with a member of the opposite sex. When that happened, the organic material making up their bodies would meld into one. Two-thirds of the material would then become fuel to power the biochemical reaction that would completely renew the cells in the remaining one-third and create a new body. Then this body would divide into three to five tiny new lives: their children. They would inherit some of the memories of their parents, continue their lives, and begin the cycle of life anew.

A more appropriate statement would be that, if you store more calories than you expend you'll gain weight. Store being the operative word there and a rather obvious observation to make about someone that is getting heavier. This more appropriate statement allows us to ask the question, why are you storing more body fat than you're losing? Is it because of the total calories you consumed, or is it because of a biochemical stimulus that makes your fat tissue grow created from the quality and quantity of foods and drinks that you consume.

Organisms are Algorithms How can we be sure that animals such as pigs actually have a subjective world of needs, sensations and emotions? Aren’t we guilty of humanising animals, i.e. ascribing human qualities to non-human entities, like children believing that dolls feel love and anger? In fact, attributing emotions to pigs doesn’t humanise them. It ‘mammalises’ them. For emotions are not a uniquely human quality – they are common to all mammals (as well as to all birds and probably to some reptiles and even fish). All mammals evolved emotional abilities and needs, and from the fact that pigs are mammals we can safely deduce that they have emotions.16 In recent decades life scientists have demonstrated that emotions are not some mysterious spiritual phenomenon that is useful just for writing poetry and composing symphonies. Rather, emotions are biochemical algorithms that are vital for the survival and reproduction of all mammals. What does this mean? Well, let’s begin by explaining what an algorithm is. This is of great importance not only because this key concept will reappear in many of the following chapters, but also because the twenty-first century will be dominated by algorithms. ‘Algorithm’ is arguably the single most important concept in our world. If we want to understand our life and our future, we should make every effort to understand what an algorithm is, and how algorithms are connected with emotions. An algorithm is a methodical set of steps that can be used to make calculations, resolve problems and reach decisions. An algorithm isn’t a particular calculation, but the method followed when making the calculation.

If the social stress is physical, sexual, or emotional abuse, the way to treat the depression is to stop the abuse. Unfortunately, advocates of the biochemical treatment of depression have gone along with the view of academic theory and popular culture that the problem is entirely within the skull of the victim. Enthusiasm for biochemical treatment and research is partly due to the fact that it helps perpetuate the myth that suicide and depression should be treated by changing the victim, not by changing ourselves. As long as we have a narrow view of the causes of biochemical imbalance, such as limiting it to innate genetic defects, we can practice denial on the social complicity in the causation of suicide. The narrow view does nothing to help reduce pain and increase resources for the millions of people whose problems do not respond to medications. It also deprives us of an opportunity for progress in a much broader area for social reform. The dynamics behind the oppression of the suicidal is similar to the dynamics of other forms of injustice; progress in one area can support progress in other areas.

Because we are not powerless biochemical machines, popping a pill every time we are mentally or physically out of tune is not the answer. Drugs and surgery are powerful tools when they are not overused, but the notion of simple drug fixes is fundamentally flawed. Every time a drug is introduced into the body to correct function A, it inevitably throws off function B, C, or D. It is not gene-directed hormones and neurotransmitters that control our bodies and our minds; our beliefs control our bodies, our minds, and thus our lives … Oh ye of little belief!

By the end of the nineteenth century, however, the vis medicatrix naturae falls out of favor among Western bioscientists. Deemed unduly vitalistic by scientific medicine’s increasingly reductionist paradigms (which pursue biochemical explanations for biological processes), “healing” be comes a more and more anachronistic notion. Instead, bracketing healing as an improperly fuzzy premise, scientific medicine embraces a highly complex, if not paradoxical, legal rubric—or even, perhaps, legal ruse. Though we do not always fully appreciate it, immunity is somewhat of a trickster

Listen, Google,’ I will say, ‘both John and Paul are courting me. I like both of them, but in a different way, and it’s so hard to make up my mind. Given everything you know, what do you advise me to do?’ And Google will answer: ‘Well, I know you from the day you were born. I have read all your emails, recorded all your phone calls, and know your favourite films, your DNA and the entire history of your heart. I have exact data about each date you went on, and if you want, I can show you second-by-second graphs of your heart rate, blood pressure and sugar levels whenever you went on a date with John or Paul. If necessary, I can even provide you with accurate mathematical ranking of every sexual encounter you had with either of them. And naturally enough, I know them as well as I know you. Based on all this information, on my superb algorithms, and on decades’ worth of statistics about millions of relationships – I advise you to go with John, with an 87 per cent probability of being more satisfied with him in the long run. Indeed, I know you so well that I also know you don’t like this answer. Paul is much more handsome than John, and because you give external appearances too much weight, you secretly wanted me to say “Paul”. Looks matter, of course; but not as much as you think. Your biochemical algorithms – which evolved tens of thousands of years ago in the African savannah – give looks a weight of 35 per cent in their overall rating of potential mates. My algorithms – which are based on the most up-to-date studies and statistics – say that looks have only a 14 per cent impact on the long-term success of romantic relationships. So, even though I took Paul’s looks into account, I still tell you that you would be better off with John.

Most fans of forensic books and television shows are aware that the biochemical building blocks of DNA can be assembled in many billions of different ways, ensuring that no two people—except for identical twins—will possess the same genetic “fingerprint.” Not many of those same people realize that there are likewise billions of possible combinations of tooth shapes, sizes, orientations, and anomalies, including cavities, fillings, chips, and distinctively shaped roots. Although identical twins can’t be distinguished from one another by their DNA, they can be told apart by their teeth.

There is only one historical development that has real significance. Today, when we finally realise that the keys to happiness are in the hands of our biochemical system, we can stop wasting our time on politics and social reforms, putsches and ideologies, and focus instead on the only thing that can make us truly happy: manipulating our biochemistry. If we invest billions in understanding our brain chemistry and developing appropriate treatments, we can make people far happier than ever before, without any need of revolutions. Prozac, for example, does not change regimes, but by raising serotonin levels it lifts people out of their depression.

​The human brain, that incredibly powerful personal biochemical computer that each of us has, is capable of doing for you anything reasonable that you’d like it to do. But you have to know how to treat it; you have to know how to wire it in the right way. If you do it right, and give it the right directions, it will do the right thing—it will work for you in the right way. ​But if you give your mental computer the wrong directions, it will act on those wrong directions; it will continue to respond to the negative programming that you and the rest of the world have been giving it. You have literally been wiring your brain in the wrong way, physically—without even being aware of it.

Anything perceived as a threat trips the amygdala—the brain’s hand-wringing sentry—to set in motion the biochemical cascade known as the fight-or-flight response. Bruce Siddle, who consults in this area and sits on the board of Strategic Operations, prefers the term “survival stress response.” Whatever you wish to call it, here is a nice, concise summary, courtesy of Siddle: “You become fast, strong, and dumb.” Our hardwired survival strategy evolved back when threats took the form of man-eating mammals, when hurling a rock superhumanly hard or climbing a tree superhumanly fast gave you the edge that might keep you alive. A burst of adrenaline prompts a cortisol dump to the bloodstream. The cortisol sends the lungs into overdrive to bring in more oxygen, and the heart rate doubles or triples to deliver it more swiftly. Meanwhile the liver spews glucose, more fuel for the feats at hand. To get the goods where the body assumes they’re needed, blood vessels in the large muscles of the arms and legs dilate, while vessels serving lower-priority organs (the gut, for example, and the skin) constrict. The prefrontal cortex, a major blood guzzler, also gets rationed. Good-bye, reasoning and analysis. See you later, fine motor skills. None of that mattered much to early man. You don’t need to weigh your options in the face of a snarling predator, and you don’t have time.

The night before a biochemistry class, I read the last year's lecture notes. I look at the pictures in the book. Now, I've got the general concept. Sure...There's a couple of details to fill in and a a few things to memorize. But that's no big deal. I've got the big picture, and that's all I need. Bring it on professor, I'm ready. That's right. The next day, I'm a goalie sitting in the front row. "Nothin gets past me." My ability to comprehend a biochemistry lecture just went from 30% to 95%. I went on to score 780 out of a possible 800 on the medical school boards exam in biochemistry. Given that the 99th percentile began around 690, this was one of the highest scores in the USA, perhaps the highest.

Some scholars compare human biochemistry to an air-conditioning system that keeps the temperature constant, come heatwave or snowstorm. Events might momentarily change the temperature, but the air-conditioning system always returns the temperature to the same set point. Some air-conditioning systems are set at 70 degrees Fahrenheit. Others are set at twenty degrees. Human happiness conditioning systems also differ from person to person. On a scale from one to ten, some people are born with a cheerful biochemical system that allows their mood to swing between levels six and ten, stabilising with time at eight. Such a person is quite happy even if she lives in an alienating big city, loses all her money in a stock-exchange crash and is diagnosed with diabetes. Other people are cursed with a gloomy biochemistry that swings between three and seven and stabilises at five. Such an unhappy person remains depressed even if she enjoys the support of a tight-knit community, wins millions in the lottery and is as healthy as an Olympic athlete. Indeed, even if our gloomy friend wins $50,000,000 in the morning, discovers the cure for both AIDS and cancer by noon, makes peace between Israelis and Palestinians that afternoon, and then in the evening reunites with her long-lost child who disappeared years ago - she would still be incapable of experiencing anything beyond level seven happiness. Her brain is simply not built for exhilaration, come what may.

Dangerousness A fairly common perception is that people with mental illness are disproportionately involved in violent crime. This is true in one respect but not in another. A small subset of people with mental illness, those who are actively experiencing serious psychotic symptoms, are more violent than the general population. Research suggests several factors associated with this group’s violent behavior, including drug and alcohol abuse, noncompliance with medication requirements, and biological or biochemical disorders.[8] In general, however, “violent and criminal acts directly attributable to mental illness account for a very small proportion of all such acts in the United States. Most persons with mental illness are not criminals, and of those who are, most are not violent.” [9]

We have to dare to be ourselves, however frightening or strange that self may prove to be. - May Sarton You see, I am a poet, and not quite right in the head, darling. It's only that. - Edna St. Vincent Millay We are slowed down sound and light waves, a walking bundle of frequencies tuned into the cosmos. We are souls dressed up in sacred biochemical garments and our bodies are the instruments through which our souls play their music. - Albert Einstein ————- Eventually soulmates meet, for they have the same hiding place. - Robert Brault Some things arrive on their own mysterious hour, on their own terms and not yours, to be seized or relinquished forever. - Gail Godwin Art makes us exercise the weakest muscle in the human body, the muscle of empathy. - Etgar Keret In the history of old Jewish literature there was never any basic difference between the poet and the prophet. Our ancient poetry often became law and a way of life. - Isaac Bashevis Singer ——————————————————————————— I am not belittling the brave pioneer men but the sunbonnet as well as the sombrero has helped to settle this glorious land of ours. - Edna Ferber You lose in the end unless you know how the wheel is fixed or can fix it yourself. - Edna Ferber What is most beautiful in virile men is something feminine; what is most beautiful in feminine women is something masculine. - Susan Sontag ——————————————————————————— There comes a time when suddenly you realize that laughter is something you remember and that you were the one laughing. - Marlene Dietrich We work in the dark, We do what we can, We give what we have. Our doubt is our passion, and our passion is our task. The rest is the madness of art. - Henry James

There is only one historical development that has real significance. Today, when we finally realise that the keys to happiness are in the hands of our biochemical system, we can stop wasting our time on politics and social reforms, putsches and ideologies, and focus instead on the only thing that can make us truly happy: manipulating our biochemistry. If we invest billions in understanding our brain chemistry and developing appropriate treatments, we can make people far happier than ever before, without any need of revolutions. Prozac, for example, does not change regimes, but by raising serotonin levels it lifts people out of their depression. Nothing captures the biological argument better than the famous New Age slogan: ‘Happiness begins within.’ Money, social status, plastic surgery, beautiful houses, powerful positions – none of these will bring you happiness. Lasting happiness comes only from serotonin, dopamine and oxytocin.1 In Aldous Huxley’s dystopian novel Brave New World, published in 1932 at the height of the Great Depression, happiness is the supreme value and psychiatric drugs replace the police and the ballot as the foundation of politics. Every day, each person takes a dose of ‘soma’, a synthetic drug which makes people happy without harming their productivity and efficiency. The World State that governs the entire globe is never threatened by wars, revolutions, strikes or demonstrations, because all people are supremely content with their current conditions, whatever they may be. Huxley’s vision of the future is far more troubling than George Orwell’s Nineteen Eighty-Four. Huxley’s world seems monstrous to most readers, but it is hard to explain why. Everybody is happy all the time – what could be wrong with that?

Nobody is ever made happy by winning the lottery, buying a house, getting a promotion or even finding true love. People are made happy by one thing and one thing only – pleasant sensations in their bodies. A person who just won the lottery or found new love and jumps from joy is not really reacting to the money or the lover. She is reacting to various hormones coursing through her bloodstream and to the storm of electric signals flashing between different parts of her brain. Unfortunately for all hopes of creating heaven on earth, our internal biochemical system seems to be programmed to keep happiness levels relatively constant. There's no natural selection for happiness as such - a happy hermit's genetic line will go extinct as the genes of a pair of anxious parents get carried on to the next generation. Happiness and misery play a role in evolution only to the extent that they encourage or discourage survival and reproduction. Perhaps it's not surprising, then, that evolution has moulded us to be neither too miserable nor too happy. It enables us to enjoy a momentary rush of pleasant sensations, but these never last for ever. Sooner of later they subside and give place to unpleasant sensations. (...) Some scholars compare human biochemistry to an air-conditioning system that keeps the temperature constant, come heatwave or snowstorm. Events might momentarily change the temperature, but the air-conditioning system always returns the temperature to the same set point. Some air-conditioning systems are set at twenty-five degrees Celsius. Others are set at twenty degrees. Human happiness conditioning systems also differ from person to person. On a scale from one to ten, some people are born with a cheerful biochemical system that allows their mood to swing between levels six and ten, stabilising with time at eight. Such a person is quite happy even if she lives in an alienating big city, loses all her money in a stock-exchange crash and is diagnosed with diabetes. Other people are cursed with a gloomy biochemistry that swings between three and seven and stabilises at five. Such an unhappy person remains depressed even if she enjoys the support of a tight-knit community, wins millions in the lottery and is as healthy as an Olympic athlete (...) incapable of experiencing anything beyond level seven happiness. Her brain is simply not built for exhilaration, come what may. (...) Buying cars and writing novels do not change our biochemistry. They can startle it for a fleeting moment, but it is soon back to the set point.

When Dennis McKenna drank ayahuasca , he had a vision in which he became “a sentient water molecule, percolating randomly through the soil, lost amid the tangle of the enormous root fibers of the Banisteriopsis World Tree.” I could feel the coolness, the dank dampness of the soil surrounding me. I felt suspended in an enormous underground cistern, a single drop among billions of drops … as if squeezed by the implacable force of irresistible osmotic pressures, I was rapidly translocated into the roots of the Banisteriopsis tree …” He was “carried through the articulating veins toward some unknown destination”. McKenna found himself within the extraordinary cellular mechanisms that turn light into “the molecular stuff of life”. Pulled on a kind of conveyor belt to the place where photosynthesis occurs. His consciousness exploded as he was “smited by the bolt of energy emitted by the phytic acid transducers and my poor water-molecule soul was split asunder”. As this vision ended, he found himself “embedded in the matrix” of the plant’s biochemical makeup. Suddenly he was suspended above the Amazon rainforest, looking over its vast expanse: “The vista stretching to the curved horizon was blue and green and bluish green, the vegetation below, threaded with shining rivers, looked like green mold covering an overgrown petri plate.” McKenna felt: “anger and rage toward my own rapacious, destructive species, scarcely aware of its own devastating power, a species that cares little about the swath of destruction it leaves in its wake as it thoughtlessly decimates ecosystems and burns thousands of acres of rainforest.” He wept. Suddenly a voice spoke to him: “You monkeys only think you’re running things. You don’t think we would really allow this to happen, do you?

Sinyukhin began by cutting one branch from each of a series of tomato plants. Then he took electrical measurements around the wound as each plant healed and sent out a new shoot near the cut. He found a negative current—a stream of electrons—flowing from the wound for the first few days. A similar "current of injury" is emitted from all wounds in animals. During the second week, after a callus had formed over the wound and the new branch had begun to form, the current became stronger and reversed its polarity to positive. The important point wasn't the polarity—the position of the measuring electrode with respect to a reference electrode often determines whether a current registers as positive or negative. Rather, Sinyukhin's work was significant because he found a change in the current that seemed related to reparative growth. Sinyukhin found a direct correlation between these orderly electrical events and biochemical changes: As the positive current increased,cells in the area more than doubled their metabolic rate, also becoming more acidic and producing more vitamin C than before. Sinyukhin then applied extra current, using small batteries, to a group of newly lopped plants, augmenting the regeneration current.These battery-assisted plants restored their branches up to three times faster than the control plants. The currents were very small—only 2 to 3 microamperes for five days. (An ampere is a standard unit of electric current, and a microampere is one millionth of an ampere.) Larger amounts of electricity killed the cells and had no growth-enhancing effect. Moreover, the polarity had to match that normally found in the plant. When Sinyukhin used current of the opposite polarity, nullifying the plant's own current, restitution was delayed by two or three weeks.

To reason about something is to proceed from one premise or proposition or concept to another, in order ideally to arrive at some conclusion, and in a coherent sequence whose connections are determined by the semantic content of each of the steps taken—each individual logical syntagma of the argument, each clause or sentence or symbol. In a simple syllogism, for example, two premises in conjunction inevitably produce a conclusion determined by their logical content. “Every rose in my garden is red; the rose I am looking at now is in my garden; therefore, the rose I am looking at now is red.” But then the series of steps by which the mind arrives at the conclusion of a series of propositions simply cannot be identical with a series of brute events in the biochemistry of the brain. If the mechanical picture of nature is correct, after all, any sequence of physical causes and effects is determined entirely by the impersonal laws governing the material world. One neuronal event can cause another as a result of physical necessity, but certainly not as a result of logical necessity. And yet the necessary connection that exists between the addition of two numbers and the sum thereby yielded is one produced entirely by the conceptual content of the various terms of the equation, and not by any set of biochemical contingencies. Conversely, if the tenets of mechanistic materialism are sound, the mere semantic content of a thought should not be able to affect the course of physical events in the cerebrum. Even if the long process of human evolution has produced a brain capable of reason, the brain cannot produce the actual contents of reasoning; the connections among the brain’s neurons cannot generate the symbolic and conceptual connections that compose an act of consecutive logic, because the brain’s neurons are related to one another organically and therefore interact physically, not conceptually. Clearly, then, there are mental events that cannot be reduced to mechanical electrochemical processes.

What are these substances? Medicines or drugs or sacramental foods? It is easier to say what they are not. They are not narcotics, nor intoxicants, nor energizers, nor anaesthetics, nor tranquilizers. They are, rather, biochemical keys which unlock experiences shatteringly new to most Westerners. For the last two years, staff members of the Center for Research in Personality at Harvard University have engaged in systematic experiments with these substances. Our first inquiry into the biochemical expansion of consciousness has been a study of the reactions of Americans in a supportive, comfortable naturalistic setting. We have had the opportunity of participating in over one thousand individual administrations. From our observations, from interviews and reports, from analysis of questionnaire data, and from pre- and postexperimental differences in personality test results, certain conclusions have emerged. (1) These substances do alter consciousness. There is no dispute on this score. (2) It is meaningless to talk more specifically about the “effect of the drug.” Set and setting, expectation, and atmosphere account for all specificity of reaction. There is no “drug reaction” but always setting-plus-drug. (3) In talking about potentialities it is useful to consider not just the setting-plus-drug but rather the potentialities of the human cortex to create images and experiences far beyond the narrow limitations of words and concepts. Those of us on this research project spend a good share of our working hours listening to people talk about the effect and use of consciousness-altering drugs. If we substitute the words human cortex for drug we can then agree with any statement made about the potentialities—for good or evil, for helping or hurting, for loving or fearing. Potentialities of the cortex, not of the drug. The drug is just an instrument. In analyzing and interpreting the results of our studies we looked first to the conventional models of modern psychology—psychoanalytic, behavioristic—and found these concepts quite inadequate to map the richness and breadth of expanded consciousness. To understand our findings we have finally been forced back on a language and point of view quite alien to us who are trained in the traditions of mechanistic objective psychology. We have had to return again and again to the nondualistic conceptions of Eastern philosophy, a theory of mind made more explicit and familiar in our Western world by Bergson, Aldous Huxley, and Alan Watts. In the first part of this book Mr. Watts presents with beautiful clarity this theory of consciousness, which we have seen confirmed in the accounts of our research subjects—philosophers, unlettered convicts, housewives, intellectuals, alcoholics. The leap across entangling thickets of the verbal, to identify with the totality of the experienced, is a phenomenon reported over and over by these persons.

REPROGRAMMING MY BIOCHEMISTRY A common attitude is that taking substances other than food, such as supplements and medications, should be a last resort, something one takes only to address overt problems. Terry and I believe strongly that this is a bad strategy, particularly as one approaches middle age and beyond. Our philosophy is to embrace the unique opportunity we have at this time and place to expand our longevity and human potential. In keeping with this health philosophy, I am very active in reprogramming my biochemistry. Overall, I am quite satisfied with the dozens of blood levels I routinely test. My biochemical profile has steadily improved during the years that I have done this. For boosting antioxidant levels and for general health, I take a comprehensive vitamin-and-mineral combination, alpha lipoic acid, coenzyme Q10, grapeseed extract, resveratrol, bilberry extract, lycopene, silymarin (milk thistle), conjugated linoleic acid, lecithin, evening primrose oil (omega-6 essential fatty acids), n-acetyl-cysteine, ginger, garlic, l-carnitine, pyridoxal-5-phosphate, and echinacea. I also take Chinese herbs prescribed by Dr. Glenn Rothfeld. For reducing insulin resistance and overcoming my type 2 diabetes, I take chromium, metformin (a powerful anti-aging medication that decreases insulin resistance and which we recommend everyone over 50 consider taking), and gymnema sylvestra. To improve LDL and HDL cholesterol levels, I take policosanol, gugulipid, plant sterols, niacin, oat bran, grapefruit powder, psyllium, lecithin, and Lipitor. To improve blood vessel health, I take arginine, trimethylglycine, and choline. To decrease blood viscosity, I take a daily baby aspirin and lumbrokinase, a natural anti-fibrinolytic agent. Although my CRP (the screening test for inflammation in the body) is very low, I reduce inflammation by taking EPA/DHA (omega-3 essential fatty acids) and curcumin. I have dramatically reduced my homocysteine level by taking folic acid, B6, and trimethylglycine (TMG), and intrinsic factor to improve methylation. I have a B12 shot once a week and take a daily B12 sublingual. Several of my intravenous therapies improve my body’s detoxification: weekly EDTA (for chelating heavy metals, a major source of aging) and monthly DMPS (to chelate mercury). I also take n-acetyl-l-carnitine orally. I take weekly intravenous vitamins and alpha lipoic acid to boost antioxidants. I do a weekly glutathione IV to boost liver health. Perhaps the most important intravenous therapy I do is a weekly phosphatidylcholine (PtC) IV, which rejuvenates all of the body’s tissues by restoring youthful cell membranes. I also take PtC orally each day, and I supplement my hormone levels with DHEA and testosterone. I take I-3-C (indole-3-carbinol), chrysin, nettle, ginger, and herbs to reduce conversion of testosterone into estrogen. I take a saw palmetto complex for prostate health. For stress management, I take l-theonine (the calming substance in green tea), beta sitosterol, phosphatidylserine, and green tea supplements, in addition to drinking 8 to 10 cups of green tea itself. At bedtime, to aid with sleep, I take GABA (a gentle, calming neuro-transmitter) and sublingual melatonin. For brain health, I take acetyl-l-carnitine, vinpocetine, phosphatidylserine, ginkgo biloba, glycerylphosphorylcholine, nextrutine, and quercetin. For eye health, I take lutein and bilberry extract. For skin health, I use an antioxidant skin cream on my face, neck, and hands each day. For digestive health, I take betaine HCL, pepsin, gentian root, peppermint, acidophilus bifodobacter, fructooligosaccharides, fish proteins, l-glutamine, and n-acetyl-d-glucosamine. To inhibit the creation of advanced glycosylated end products (AGEs), a key aging process, I take n-acetyl-carnitine, carnosine, alpha lipoic acid, and quercetin. MAINTAINING A POSITIVE “HEALTH SLOPE” Most important,