Bacterial Life Quotes

At one time, we thought that the way life came together was almost completely random, only needing an energy gradient to get going. But as we’ve moved into the information age, we’ve come to realize that life is more about information than energy. Fire has most of the characteristics of life. It eats, it grows, it reproduces. But fire retains no information. It doesn’t learn; it doesn’t adapt. The five millionth fire started by lightning will behave just like the first. But the five hundredth bacterial division will not be like the first one, especially if there is environmental pressure. That’s DNA. And RNA. That’s life. …

Look at life from our perspective, and you eukaryotes will soon cease giving yourselves such airs. You bipedal apes, you stump-tailed tree-shrews, you desiccated lobe-fins, you vertebrated worms, you Hoxed-up sponges, you newcomers on the block, you eukaryotes, you barely distinguishable congregations of a monotonously narrow parish, you are little more than fancy froth on the surface of bacterial life. Why, the very cells that build you are themselves colonies of bacteria, replaying the same old tricks we bacteria discovered a billion years ago. We were here before you arrived, and we shall be here after you are gone.

It's about the connecting force from form to form. It's the toe bone connecting to the shoulder bone. It's the bacterial kick of life force, something growing out of nothing, forming itself out of something else. Form never stops. And form is always environmental.

Throughout 150 years of the science of bacteriology, there is no evidence that one species of bacteria has changed into another... Since there is no evidence for species changes between the simplest forms of unicellular life, it is not surprising that there is no evidence for evolution from prokaryotic [i.e., bacterial] to eukaryotic [i.e., plant and animal] cells, let alone throughout the whole array of higher multicellular organisms.

The Gaian ecosystem, the self-organized system that we know as Earth, came into being with the emergence of the global bacterial community. That bacterial community still is the foundation of this world. It is Gaia. It is the interconnected network of millions of bacterial biofilms, individual bacteria, and symbiogenic, bacterially generated, complex life-forms that lies deep within the crust of the Earth (perhaps by as much as 5 kilometers), covers the entire surface of the planet, and extends at least 50 kilometers above the Earth’s surface. The Earth itself is around 4.5 billion years old but sometime in its first half to one billion years of existence bacterial life emerged.

Winning the Origins Lottery Nontheistic models adhere to a central premise that humans arose by strictly natural unguided steps from a bacterial life-form that sprang into being 3.8 billion years ago. Famed evolutionary biologist Francisco Ayala, an advocate for the hypothesis that natural selection and mutations can efficiently generate distinctly different species, nevertheless calculated the probability that humans (or a similarly intelligent species) arose from single-celled organisms as a possibility so small (10-1,000,000) that it might as well be zero (roughly equivalent to the likelihood of winning the California lottery 150,000 consecutive times with the purchase of just one ticket each time).2 He and other evolutionary biologists agree that natural selection and mutations could have yielded any of a virtually infinite number of other outcomes. Astrophysicists Brandon Carter, John Barrow, and Frank Tipler produced an even smaller probability.

The largest ecosystem known is the bacterial world that exists in the basalt layers two miles deep in the ocean, underneath and inside the basalt layers that exist another 100 to 500 feet beneath the water. This “seam” of bacterial life extends completely around the globe, a single unified ecosystem that is foundational to everything above it.

two billion years bacterial organisms were the only forms of life. They lived, they reproduced, they swarmed, but they didn’t show any particular inclination to move on to another, more challenging level of existence.

The contamination of drinking water in dense urban settlements did not merely affect the number of V. cholerae circulating through the small intestines of mankind. It also greatly increased the lethality of the bacteria. This is an evolutionary principle that has long been observed in populations of disease-spreading microbes. Bacteria and viruses evolve at much faster rates than humans do, for several reasons. For one, bacterial life cycles are incredibly fast: a single bacterium can produce a million offspring in a matter of hours. Each new generation opens up new possibilities for genetic innovation, either by new combinations of existing genes or by random mutations. Human genetic change is several orders of magnitude slower; we have to go through a whole fifteen-year process of maturation before we can even think about passing our genes to a new generation.

Weizmann was a brilliant biochemist who had emigrated from Russia to England, where he helped his adopted nation in the First World War by coming up with a bacterial method for more efficiently manufacturing the explosive cordite.

It seems to me the simplest explanation,” he told the audience, “is that they are all HeLa cell contaminants.” Scientists knew they had to keep their cultures free from bacterial and viral contamination, and they knew it was possible for cells to contaminate one another if they got mixed up in culture. But when it came to HeLa, they had no idea what they were up against. It turned out Henrietta’s cells could float through the air on dust particles. They could travel from one culture to the next on unwashed hands or used pipettes; they could ride from lab to lab on researchers’ coats and shoes, or through ventilation systems. And they were strong: if just one HeLa cell landed in a culture dish, it took over, consuming all the media and filling all the space.

In the short term, adrenaline gives our immune function a boost to help fight bacterial and viral infections. But in the longer term, over-production of adrenaline and abnormal patterns of cortisol are linked with shorter life expectancy (Kumari et al., 2011). When adrenaline is repeatedly propping up our immune system through chronic stress and then we stop and the adrenaline goes down, so does the immune system. This is why you often hear of people who work incredibly hard around the clock for months on end and when they finally stop to take a holiday they almost immediately fall ill.

For nearly the entire history of life on this planet, 85 percent of that history in fact, life consisted solely of microorganisms. The last universal common ancestor (LUCA) for every life-form on this planet was bacterial. Again: The last universal common ancestor for every life-form on this planet was bacterial.

In addition to these physical problems, sexually transmitted diseases are rampant among the homosexual population. 75% of homosexual men carry one or more sexually transmitted diseases, wholly apart from AIDS. These include all sorts of non-viral infections like gonorrhea, syphilis, bacterial infections, and parasites. Also common among homosexuals are viral infections like herpes and hepatitis B (which afflicts 65% of homosexual men), both of which are incurable, as well as hepatitis A and anal warts, which afflict 40% of homosexual men. And I haven’t even included AIDS. Perhaps the most shocking and frightening statistic is that, leaving aside those who die from AIDS, the life expectancy for a homosexual male is about 45 years of age. That compares to a life expectancy of around 70 for men in general. If you include those who die of AIDS, which now infects 30% of homosexual men, the life expectancy drops to 39 years of age. So I think a very good case can be made out on the basis of generally accepted moral principles that homosexual behavior is wrong. It is horribly self-destructive and injurious to another person. Thus, wholly apart from the Bible’s prohibition, there are sound, sensible reasons to regard homosexual activity as wrong.

Fire has most of the characteristics of life. It eats, it grows, it reproduces. But fire retains no information. It doesn’t learn; it doesn’t adapt. The five millionth fire started by lightning will behave just like the first. But the five hundredth bacterial division will not be like the first one, especially if there is environmental pressure.

Life displays mad hospitality. The Korean biologist Kwang Jeon of the University of Tennessee received in the 1970s a batch of amoebas infected with a deadly bacterial strain. Most died. In a set of careful experiments after culturing the survivor amoebas for several generations, he found that the survivors, with fewer bacteria per cell, could no longer live without their infection.

Three postcards await our perusal, yea, three visions of a world. One: I see a theme park where there are lots of rides, but there is nobody who can control them and nobody who knows how the rides end. Grief counseling, however, is included in the price of admission. Two: I see an accident. An explosion of some kind inhabited by happenstantial life forms. A milk spill gone bacterial, only with more flame. It has no meaning or purpose or master. It simply is. Three: I see a stage, a world where every scene is crafted. Where men act out their lives within a tapestry, where meaning and beauty exist, where right and wrong are more than imagined constructs. There is evil. There is darkness. There is the Winter of tragedy, every life ending, churned back into the soil. But the tragedy leads to Spring. The story does not end in frozen death. The fields are sown in grief. The harvest will be reaped in joy. I see a Master's painting. I listen to a Master's prose. When darkness falls on me, when I stand on my corner of the stage and hear my cue, when I know my final scene has come and I must exit, I will go into the ground like corn, waiting for the Son.

The two researchers collaborated on a pilot study.32 What they found was that loneliness reprogrammed a person’s genes in the same way that fear of being outed altered the genes of closeted men. Loneliness changes the immune system. Specifically, feeling isolated turns on genes for inflammation—which are the first responders to tissue damage or bacterial threats—and it puts the brakes on genes that stop inflammation

I think we can reasonably conclude that complex life will be rare in the universe – there is no innate tendency in natural selection to give rise to humans or any other form of complex life. It is far more likely to get stuck at the bacterial level of complexity. I can’t put a statistical probability on that. The existence of Parakaryon myojinensis might be encouraging for some – multiple origins of complexity on earth means that complex life might be more common elsewhere in the universe. Maybe. What I would argue with more certainty is that, for energetic reasons, the evolution of complex life requires an endosymbiosis between two prokaryotes, and that is a rare random event, disturbingly close to a freak accident, made all the more difficult by the ensuing intimate conflict between cells. After that, we are back to standard natural selection.

2Do not mistake these multiple trends--the energy flows of metropolitan growth, the new taste for tea, the nascent, half-formed awareness of mass behavior--for mere historical background. The clash of microbe and man that played out on Broad Street for ten days in 1854 was itself partly a consequence of each of these trends, though the chains of cause and effect played out on different scales of experience, both temporal and spatial. You can tell the story of the Broad Street outbreak on the scale of a few human human lives, people drinking water from the a pump, getting sick and dying over a few weeks, but in telling the story that way, you limit its perspective, limits its ability to convey a fair account of what really happened. Once you get to the why, the story has to widen and tighten at the same time: to the long duree of urban development, or the microscopic tight focus of bacterial life cycles, These are causes, too.

In his paper entitled 'Bacterial Growth: Constant obsession with dN/dt,' Frederick Neidhardt (1999) tells us: 'One of life's inevitable disappointments - one felt often by scientists and artists, but not only by them - comes form expecting others to share the particularities of one's own sense of awe and wonder. This truth came home to me recently when I picked up Michael Guillen's fine book Five Equations That Changed the World and discovered that my equation - the one that shaped my scientific career - was not considered one of the five.

[from an entry by her daughter Camille] On the other hand, if cattle remain on pasture right to the end, that kind of beef is called "grass finished." The difference between this and CAFO beef are not just relevant to how kindly you feel about animals: meat and eggs of pastured animals also have a measurably different nutrient composition. A lot of recent research has been published on this subject, which is slowly reaching the public. USDA studies found much lower levels of saturated fats and higher vitamin E, beta-carotene, and omega-3 levels in meat from cattle fattened on pasture grasses (their natural diet), compared with CAFO animals ... Free-range beef also has less danger of bacterial contamination because feeding on grass maintains normal levels of acidity in the animal's stomach. At the risk of making you not want to sit at my table, I should tell you that the high-acid stomachs of grain-fed cattle commonly harbor acid-resistant strains of E. coli that are very dangerous to humans ... Free-range grazing is not just kinder to the animals and the surrounding environment; it produces an entirely different product.

The way to peer into life’s past is to examine fossils and to determine when a branch was first created by assessing the age of rocks when a certain fossil was formed. The oldest known fossils are of bacteria that apparently lived in ponds or a shallow sea located in what is now western Australia. They are fossil mats of bacteria, called stromatolites, whose metabolism led them to excrete calcium carbonate, chalk, the stuff of seashells and limestone. The ancient ponds dried up for some climatological reason, and these bacterial mats turned to stone. They’re 3.5 billion years old. As

At one time, we thought that the way life came together was almost completely random, only needing an energy gradient to get going. But as we’ve moved into the information age, we’ve come to realize that life is more about information than energy. Fire has most of the characteristics of life. It eats, it grows, it reproduces. But fire retains no information. It doesn’t learn; it doesn’t adapt. The five millionth fire started by lightning will behave just like the first. But the five hundredth bacterial division will not be like the first one, especially if there is environmental pressure. That’s DNA. And RNA. That’s life. … Dr. Steven Carlisle, from the Convention panel Exploring the Galaxy

Lignin is a linkage of three aromatic alcohols—coumaryl, coniferyl, and sinapyl—which fill the spaces in cell walls that are not already occupied by other substances, even ousting water molecules to do so. It thus forms a very strong hydrophobic net, cementing all the cell-wall elements in place and providing strength and rigidity to the xylem. It also provides an important barrier to fungal and bacterial infections. When a tree is invaded by disease, it seals off the infected section with a wall of lignin so that the disease cannot spread. Lignin is so tough that getting rid of it is a costly process in pulp-and-paper plants. The acids needed to break down lignin in pulpwood are the chief pollutants such mills contribute to the environment.

In an extremely short period of geologic time the Earth has been saturated with several billion pounds of nonbiodegradable, often biologically unique pharmaceuticals designed to kill bacteria. Many antibiotics (literally meaning “against life”) do not discriminate in their activity, but kill broad groups of diverse bacteria whenever they are used. The worldwide environmental dumping, over the past 65 years, of such huge quantities of synthetic antibiotics has initiated the most pervasive impacts on the Earth’s bacterial underpinnings since oxygen-generating bacteria supplanted methanogens 2.5 billion years ago. As bacterial researcher Stuart Levy comments . . . It has stimulated evolutionary changes that are unparalleled in recorded biologic history.4

We may not like thinking about it, but germs crawl eternally over every speck of our planet. Our own bodies are bacterial condos, with established relationships between the upstairs and downstairs neighbors. Without these regular residents, our guts are easily taken over by less congenial newcomers looking for low-rent space. What keeps us healthy is an informed coexistence with microbes, rather than the micro-genocide that seems to be the rage lately. Germophobic parents can now buy kids' dinnerware, placemats, even clothing imbedded with antimicrobial chemicals. Anything that will stand still, if we mean to eat it, we shoot full of antibiotics. And yet, more than 5,000 people in the United States die each year from pathogens in our food. Sterility is obviously the wrong goal, especially as a substitute for careful work.

The most celebrated germ expert in the world is almost certainly Dr. Charles P. Gerba of the University of Arizona, who is so devoted to the field that he gave one of his children the middle name Escherichia, after the bacterium Escherichia coli. Dr. Gerba established some years ago that household germs are not always most numerous where you would expect them to be. In one famous survey he measured bacterial content in different rooms in various houses and found that typically the cleanest surface of all in the average house was the toilet seat. That is because it is wiped down with disinfectant more often than any other surface. By contrast the average desktop has five times more bacteria living on it than the average toilet seat. The dirtiest area of all was the kitchen sink, closely followed by the kitchen counter, and the filthiest object was the kitchen washcloth. Most kitchen cloths are drenched in bacteria, and using them to wipe counters (or plates or breadboards or greasy chins or any other surface) merely transfers microbes from one place to another, affording them new chances to breed and proliferate. The second most efficient way of spreading germs, Gerba found, is to flush a toilet with the lid up. That spews billions of microbes into the air. Many stay in the air, floating like tiny soap bubbles, waiting to be inhaled, for up to two hours; others settle on things like your toothbrush. That is, of course, yet another good reason for putting the lid down.

We can be very sure there really is a single concestor of all surviving life forms on this planet. The evidence is that all that have ever been examined share (exactly in most cases, almost exactly in the rest) the same genetic code; and the genetic code is too detailed, in arbitrary aspects of its complexity, to have been invented twice. Although not every species has been examined, we already have enough coverage to be pretty certain that no surprises—alas—await us. If we now were to discover a life form sufficiently alien to have a completely different genetic code, or one not even based on DNA, it would be the most exciting biological discovery in my adult lifetime, whether it lives on this planet or another. As things stand, it appears that all known life forms can be traced to a single ancestor which lived more than 3 billion years ago. If there were other, independent origins of life, they have left no descendants that we have discovered. And if new ones arose now they would swiftly be eaten, probably by bacteria. The grand confluence of all surviving life is not the same thing as the origin of life itself. This is because all surviving species presumably share a concestor who lived after the origin of life: anything else would be an unlikely coincidence, for it would suggest that the original life form immediately branched and more than one of its branches survive to this day. The oldest bacterial fossils found so far date to about 3.5 billion years ago, so the origin of life must at least be earlier than that. The grand confluence—the last common ancestor of all surviving creatures—could predate the oldest fossils (it didn’t fossilise) or it could have lived a billion years later (all but one of the other lineages went extinct).

Summary: Wheat Belly Detox Supplements Look for the supplements we use in the Wheat Belly 10-Day Grain Detox in health food stores. Because of regional variation in brands, the reputable brands that are available to you may differ from the ones I list below. Where national brands are widely distributed, I will specify a few quality representative ones. High-potency probiotic supplement: 30 billion to 50 billion CFUs per day for 6 to 8 weeks. My favorite brands include Garden of Life, Renew Life, and VSL#3, all of which contain a long list of preferred bacterial species, as well as high CFU counts. Vitamin D: 4,000 to 8,000 IUs per day to start for adults, as gelcaps or drops; long-term dose adjusted to achieve a 25-hydroxy vitamin D blood level of 60 to 70 ng/mL. Excellent vitamin D preparations are widely available in many brands and surprisingly low in cost. Look for oil-based gelcaps (that look like little fish oil capsules) or liquid drops, but not tablets. Even the big-box stores like Costco and Sam’s Club have excellent preparations. Magnesium: Preferably magnesium malate, 1,200 mg two or three times per day, or magnesium glycinate, 400 mg two or three times per day; or magnesium citrate, 400 mg two or three times per day. (If elemental magnesium—i.e., magnesium without the weight of malate, glycinate, or citrate—is specified on your supplement, aim for around 400 mg magnesium per day.) Source Naturals, NOW, and KAL are excellent brands. Fish oil: 3,000 to 3,600 mg per day of EPA and DHA, divided into two doses. Among my preferred brands are Nordic Naturals, Ascenta Nutra-Sea, and Carlson. Iodine: 500 to 1,000 mcg per day as potassium iodide drops or kelp tablets. Like vitamin D, there are many excellent preparations available at low cost. Iron: Look for supplements in the ferrous form and take only if low ferritin levels or iron deficiency anemia is identified; the dose depends on the severity of anemia and the form chosen. Sundown Naturals, Feosol, and Pure Encapsulations are among preferred brands. Zinc: 10 to 15 mg per day of (elemental) zinc as gluconate, sulfate, or acetate. Twinlab, Thorne, and NOW provide great choices.

This might be perhaps the simplest single-paragraphy summation of civilizational advances, a concise summary of growth that matters most. Our ability to provide a reliable, adequate food supply thanks to yields an order of magnitude higher than in early agricultures has been made possible by large energy subsidies and it has been accompanied by excessive waste. A near-tripling of average life expectancies has been achieved primarily by drastic reductions of infant mortality and by effective control of bacterial infections. Our fastest mass-travel speeds are now 50-150 times higher than walking. Per capita economic product in affluent countries is roughly 100 times larger than in antiquity, and useful energy deployed per capita is up to 200-250 times higher. Gains in destructive power have seen multiples of many (5-11) orders of magnitude. And, for an average human, there has been essentially an infinitely large multiple in access to stored information, while the store of information civilization-wide will soon be a trillion times larger than it was two millenia ago. And this is the most worrisome obverse of these advances: they have been accompanied by a multitude of assaults on the biosphere. Foremost among them has been the scale of the human claim on plants, including a significant reduction of the peak posts-glacial area of natural forests (on the order of 20%), mostly due to deforestation in temperate and tropical regions; a concurrent expansion of cropland to cover about 11% of continental surfaces; and an annual harvest of close to 20% of the biosphere's primary productivity (Smil 2013a). Other major global concerns are the intensification of natural soil erosion rates, the reduction of untouched wilderness areas to shrinking isolated fragments, and a rapid loss of biodiversity in general and within the most species-rich biomes in particular. And then there is the leading global concern: since 1850 we have emitted close to 300 Gt of fossil carbon to the atmosphere (Boden and Andres 2017). This has increased tropospheric CO2 concentrations from 280 ppm to 405 ppm by the end of 2017 and set the biosphere on a course of anthropogenic global warming (NOAA 2017). These realities clearly demonstrate that our preferences have not been to channel our growing capabilities either into protecting the biosphere or into assuring decent prospects for all newborns and reducing life's inequalities to tolerable differences. Judging by the extraordinary results that are significantly out of line with the long-term enhancements of our productive and protective abilities, we have preferred to concentrate disproportionately on multiplying the destructive capacities of our weapons and, even more so, on enlarging our abilities for the mass-scale acquisition and storage of information and for instant telecommunication, and have done so to an extent that has become not merely questionable but clearly counterproductive in many ways.

The trends speak to an unavoidable truth. Society's future will be challenged by zoonotic viruses, a quite natural prediction, not least because humanity is a potent agent of change, which is the essential fuel of evolution. Notwithstanding these assertions, I began with the intention of leaving the reader with a broader appreciation of viruses: they are not simply life's pathogens. They are life's obligate partners and a formidable force in nature on our planet. As you contemplate the ocean under a setting sun, consider the multitude of virus particles in each milliliter of seawater: flying over wilderness forestry, consider the collective viromes of its living inhabitants. The stunnig number and diversity of viruses in our environment should engender in us greater awe that we are safe among these multitudes than fear that they will harm us. Personalized medicine will soon become a reality and medical practice will routinely catalogue and weigh a patient's genome sequence. Not long thereafter one might expect this data to be joined by the patient's viral and bacterial metagenomes: the patient's collective genetic identity will be recorded in one printout. We will doubtless discover some of our viral passengers are harmful to our health, while others are protective. But the appreciation of viruses that I hope you have gained from these pages is not about an exercise in accounting. The balancing of benefit versus threat to humanity is a fruitless task. The viral metagenome will contain new and useful gene functionalities for biomedicine: viruses may become essential biomedical tools and phages will continue to optimize may also accelerate the development of antibiotic drug resistance in the post-antibiotic era and emerging viruses may threaten our complacency and challenge our society economically and socially. Simply comparing these pros and cons, however, does not do justice to viruses and acknowledge their rightful place in nature. Life and viruses are inseparable. Viruses are life's complement, sometimes dangerous but always beautiful in design. All autonomous self-sustaining replicating systems that generate their own energy will foster parasites. Viruses are the inescapable by-products of life's success on the planet. We owe our own evolution to them; the fossils of many are recognizable in ERVs and EVEs that were certainly powerful influences in the evolution of our ancestors. Like viruses and prokaryotes, we are also a patchwork of genes, acquired by inheritance and horizontal gene transfer during our evolution from the primitive RNA-based world. It is a common saying that 'beauty is in the eye of the beholder.' It is a natural response to a visual queue: a sunset, the drape of a designer dress, or the pattern of a silk tie, but it can also be found in a line of poetry, a particularly effective kitchen implement, or even the ruthless efficiency of a firearm. The latter are uniquely human acknowledgments of beauty in design. It is humanity that allows us to recognize the beauty in the evolutionary design of viruses. They are unique products of evolution, the inevitable consequence of life, infectious egotistical genetic information that taps into life and the laws of nature to fuel evolutionary invention.

We tend to be unaware that stars rise and set at all. This is not entirely due to our living in cities ablaze with electric lights which reflect back at us from our fumes, smoke, and artificial haze. When I discussed the stars with a well-known naturalist, I was surprised to learn that even a man such as he, who has spent his entire lifetime observing wildlife and nature, was totally unaware of the movements of the stars. And he is no prisoner of smog-bound cities. He had no inkling, for instance, that the Little Bear could serve as a reliable night clock as it revolves in tight circles around the Pole Star (and acts as a celestial hour-hand at half speed - that is, it takes 24 hours rather than 12 for a single revolution). I wondered what could be wrong. Our modern civilization does not ignore the stars only because most of us can no longer see them. There are definitely deeper reasons. For even if we leave the sulphurous vapours of our Gomorrahs to venture into a natural landscape, the stars do not enter into any of our back-to-nature schemes. They simply have no place in our outlook any more. We look at them, our heads flung back in awe and wonder that they can exist in such profusion. But that is as far as it goes, except for the poets. This is simply a 'gee whiz' reaction. The rise in interest in astrology today does not result in much actual star-gazing. And as for the space programme's impact on our view of the sky, many people will attentively follow the motions of a visible satellite against a backdrop of stars whose positions are absolutely meaningless to them. The ancient mythological figures sketched in the sky were taught us as children to be quaint 'shepherds' fantasies' unworthy of the attention of adult minds. We are interested in the satellite because we made it, but the stars are alien and untouched by human hands - therefore vapid. To such a level has our technological mania, like a bacterial solution in which we have been stewed from birth, reduced us. It is only the integral part of the landscape which can relate to the stars. Man has ceased to be that. He inhabits a world which is more and more his own fantasy. Farmers relate to the skies, as well as sailors, camel caravans, and aerial navigators. For theirs are all integral functions involving the fundamental principle - now all but forgotten - of orientation. But in an almost totally secular and artificial world, orientation is thought to be un- necessary. And the numbers of people in insane asylums or living at home doped on tranquilizers testifies to our aimless, drifting metaphysic. And to our having forgotten orientation either to seasons (except to turn on the air- conditioning if we sweat or the heating system if we shiver) or to direction (our one token acceptance of cosmic direction being the wearing of sun-glasses because the sun is 'over there'). We have debased what was once the integral nature of life channelled by cosmic orientations - a wholeness - to the ennervated tepidity of skin sensations and retinal discomfort. Our interior body clocks, known as circadian rhythms, continue to operate inside us, but find no contact with the outside world. They therefore become ingrown and frustrated cycles which never interlock with our environment. We are causing ourselves to become meaningless body machines programmed to what looks, in its isolation, to be an arbitrary set of cycles. But by tearing ourselves from our context, like the still-beating heart ripped out of the body of an Aztec victim, we inevitably do violence to our psyches. I would call the new disease, with its side effect of 'alienation of the young', dementia temporalis.

Prefer to use a penny? Copper is also a natural fungicide and can prevent bacterial growth on the stems, thus prolonging plant life.

Well,” Harry said, “look at it this way: Suppose you were an intelligent bacterium floating in space, and you came upon one of our communication satellites, in orbit around the Earth. You would think, What a strange, alien object this is, let’s explore it. Suppose you opened it up and crawled inside. You would find it very interesting in there, with lots of huge things to puzzle over. But eventually you might climb into one of the fuel cells, and the hydrogen would kill you. And your last thought would be: This alien device was obviously made to test bacterial intelligence and to kill us if we make a false step. “Now, that would be correct from the standpoint of the dying bacterium. But that wouldn’t be correct at all from the standpoint of the beings who made the satellite. From our point of view, the communications satellite has nothing to do with intelligent bacteria. We don’t even know that there are intelligent bacteria out there. We’re just trying to communicate, and we’ve made what we consider a quite ordinary device to do it.

osteomyelitis, a serious bacterial infection of the

The foods we eat, the air we breathe, the toxins we absorb through our skin, and the stress we manage all factor into our body’s pH. And although there’s a consensus among nutritionists and medical experts well versed in these matters that somewhere in the range of 80 percent of the foods we ingest should be alkaline-forming and 20 percent acidic, the typical American diet—combined with our fast-paced, stress-inducing urban lifestyle—is overwhelmingly acid-forming. Processed foods, sodas, meat and dairy proteins, polluted air, and simple life pressures all contribute to what is called “metabolic acidosis,” or a chronic state of body acidity. Why is this important? When the body is in a protracted or chronic state of even low-grade acidosis, which most people’s bodies these days are, it must marshal copious resources to maintain blood pH somewhere in the optimal 7.35 orbit. Over time, the body pays a significant tax that manifests in a susceptibility to any array of infirmities: fatigue; impaired sleep and immune system functionality; a decrease in cellular energy output, nutrient absorption, bone density, and growth hormone levels, which over time lead to a reduction in muscle mass; an increase in inflammation and weight gain, leading to obesity; the promotion of kidney disorders, tumor cell growth, mood swings, and osteoporosis. And I haven’t included in that list a variety of bacterial and viral maladies that flourish in the acidic environment.

The secrets of green tea Green tea has been credited for centuries with significant medicinal properties. Recent studies have confirmed its many benefits, and have attested to the importance of this ancient plant in the longevity of those who drink it often. Originally from China, where it has been consumed for millennia, green tea didn’t make its way to the rest of the world until just a few centuries ago. Unlike other teas, and as a result of being air-dried without fermentation, it retains its active elements even after being dried and crumbled. It offers meaningful health benefits such as: Controlling cholesterol Lowering blood sugar levels Improving circulation Protection against the flu (vitamin C) Promoting bone health (fluoride) Protection against certain bacterial infections Protection against UV damage Cleansing and diuretic effects White tea, with its high concentration of polyphenols, may be even more effective against aging. In fact, it is considered to be the natural product with the greatest antioxidant power in the world—to the extent that one cup of white tea might pack the same punch as about a dozen glasses of orange juice. In summary: Drinking green or white tea every day can help us reduce the free radicals in our bodies, keeping us young longer.

I began to feel as if we were merging with one another. The process was more than simply emotional. It was biological, systemic. Each of our bodies was a biosphere, slick with bacterial and insect life. Reteamed, and what we teamed with brought us closer not only to each other, but to the ecosystem we inhabited, fed off, and nourished. Bacteria bred in the ooze of our waste, our discarded food remains and puddled shit, then travelled onto us and between us, carried not only on the thickened air, but by the fleas and lice that hopped and crawled from one body to another. There was no difference, I began to think, between the puddles on the floor and the streaks of filth on my skin and the acne that erupted on Margot’s face. It was all just life, matter, the biome. We were leaking out into the world, and the pooled primordial essence of the world was soaking back into us in turn. (p.235)

We could barely even recognise each other, let alone differentiate. With our hair slicked down with awful, a faces glistening with translucent slime, our clothes rotted and tattered, and revealing bodies in equal and complementary states of decay, we appeared to each other simply as shining, semi-fluid forms in the darkness. We reached for anything we could consume - food, old and new, detritus from the floor, are own squelching shit - and washed it down with all the booze we could manage [...] If we kept on, I knew, our skin itself would leave us, rotting from our bones and pooling at her ankles, until there was nothing at all to tell one of us from the other, or any of us from anyone else. Even in the haze, I understood what I had achieved. I’d stripped everything back, rendered myself down to nothing but the shit I contained. I had transcended even wildness and animality, become bacterial, amoebic, viral. I was infinite and self-dividing, no longer near to death, but death itself, airborne and particulate. The skin of the world had been peeled away, and what was beneath, I knew was the true face of God: pulsing and writhing and ugly with life. (p.300)

The virtue of non-injury should not be taken to a fanatical level. In life, you have to balance the pair of opposites; otherwise, there will be chaos. Kindness and non-injury, for instance, has to be balanced with order and severity. If a person has a bacterial infection, he has no choice but to take antibiotics in order to kill the germs and stop the infection. If criminals were allowed to roam the city, the lives of other citizens may be endangered. That is why the state has to isolate them in prisons. It is simply a matter of peace and order.

Every multicellular organism begins as one cell, which contains all of the intricate instructions to synthesize, organize, and regulate not only this cell but the development and maintenance of all cells that will inevitably comprise the organism. All of these instructions are encoded in the first cell's DNA. This underscores the complexity of the genome and how each cell's expression must be controlled in specific ways depending on its function. The cells hailing from each tissue in the human body (e.g., muscle, lung, heart, liver) harbor a unique epigen­etic signature, which enables the maintenance of tissue-specific func­tions through the control of gene regulation, as just discussed. "Our knowledge of the total number of unique cells, or cell types, is still growing. Previous estimates put the number of unique cell types in the human body at ~300, but new estimates from the Human Cell Atlas have shown that we may have thousands of cell types and subtypes, each harboring a unique function for a specific physiological state or response to stimuli. But even cells of the same cell type will not be identical. A cell's 'presentation' of molecules on their surface can radi­cally change depending on internal variables such as genetic mutations or altered states of their epigenome, transcriptome, and proteome, as well as external stimuli including drugs and interactions with other cells. This novel presentation is most pronounced with a neoantigen, when a cancer cell creates an entirely new molecule on the surface of a cell. Given its unique presentation, which wouldn't be found in nor­mal cells, this offers a unique target for safer cancer therapies. "The human body has about 30 trillion human cells plus another 30-40 trillion bacterial cells, for a total of about 70 trillion cells. If your body were a democracy, the human cells would often be the minority or equal party. You (as a human) would never win an election. Your loss of control would likely result in you rolling around in the soil or lying in a bathtub full of yogurt, which I do sometimes on Sundays. Regard­less of how you spend your Sundays, there are a lot of microbes in, on, and around your body. There are in fact so many microbes that they compose the bulk of the cells on Earth. This is a humbling and exciting statistic, and one which is vividly apparent for anyone who has ever had explosive diarrhea.

Mary Mallon was born in 1869 in Cookstown, County Tyrone, then part of British-ruled Ireland. Like many of her countrymen, she immigrated to the United States at a young age, where she eventually found employment as a cook. During her lifetime, it was suspected that she has unintentionally (albeit perhaps negligently) infected over fifty people with typhoid. Typhoid fever is a bacterial disease caused by gastrointestinal infection by Salmonella enterica serovar Typhi. In most patients, it causes an unpleasant but manageable disease that resolves fully. However, as many as one in twenty patients become chronic carriers, who continue to be infectious for their lifetimes. Mary Mallon was one of the unfortunate few who fell into that category. It is hypothesised today that she contracted typhoid at birth. Her case, which involved prolonged quarantine on North Brother Island for almost half her life, raises complex moral and ethical questions about reconciling the interests of public health with the moral imperative to respect individual liberties and treat the sick (even if asymptomatic) with compassion.

published by Márquez et al. (2007) in Science in 2007 described “a virus in a fungus in a plant.” The plant—a tropical grass—grows naturally in high soil temperatures. But without a fungal associate that grows in its leaves, the grass can’t survive at high temperatures. When grown alone, without the plant, the fungus fares little better and is unable to survive. However, it turns out not to be the fungus that confers the ability to survive high temperatures after all. Rather, it is a virus that lives within the fungus that confers heat tolerance. When grown without the virus, neither fungus nor plant can survive high temperatures. The microbiome of the fungus, in other words, determines the role that the fungus plays in the microbiome of the plant. The outcome is clear: life or death. One of the most dramatic examples of microbes that live within microbes comes from the notorious rice blast fungus: Rhizopus microsporus. The key toxins used by Rhizopus are actually produced by a bacterium living within its hyphae. In a dramatic indication of how entwined the fates of fungi and their bacterial associates can be, Rhizopus requires the bacteria not only to cause the disease but also to reproduce. Experimentally “curing” Rhizopus of its bacterial residents impedes the fungus’s ability to produce spores. The bacterium is responsible for the most important features of Rhizopus’s lifestyle, from its diet to its sexual habits. See Araldi-Brondolo et al. (2017), Mondo et al. (2017), and Deveau

It has been said that what we face with this climate crisis is harder than winning World War II, achieving civil rights, defeating bacterial infection and sending a man to the moon . . . combined. So let’s get super duper clear, my dear friends: this is a human despair crisis. Rebecca Solnit: “The scale is not like anything human beings have faced and journalists have reported on, except perhaps the threat of all-out nuclear war.” She then added the whopper caveat that nuclear war was something that “might happen, not something that is happening.” I add this: with nuclear war, we all agreed the threat was real and we talked about it openly. We weren’t fighting the science on it. Sure, we’ve had climate change before. And, yep, the planet survived. But this is not the point. No doubt the planet will survive again. There’s just one small problem that we get distracted from. This time, we probably won’t. Or at least, our lives as we know and love them won’t….Scientists and activists have no vested interest in making this shit up. There is no money to be made and no power to be gained from spreading information about the worth of sustainable energy, or consuming less. I said this to someone who challenged me at a dinner party as to my motives behind engaging in climate activism: “We would much rather be at the beach.” Fair point, they replied.

Over the next couple of years, Cole and the rest of psychiatry settled on a trial design for testing psychotropic drugs. Psychiatrists and nurses would use “rating scales” to measure numerically the characteristic symptoms of the disease that was to be studied. Did a drug for schizophrenia reduce the patient’s “anxiety”? His or her “grandiosity”? “Hostility”? “Suspiciousness”? “Unusual thought content”? “Uncooperativeness”? The severity of all of those symptoms would be measured on a numerical scale and a total “symptom” score tabulated, and a drug would be deemed effective if it reduced the total score significantly more than a placebo did within a six-week period. At least in theory, psychiatry now had a way to conduct trials of psychiatric drugs that would produce an “objective” result. Yet the adoption of this assessment put psychiatry on a very particular path: The field would now see short-term reduction of symptoms as evidence of a drug’s efficacy. Much as a physician in internal medicine would prescribe an antibiotic for a bacterial infection, a psychiatrist would prescribe a pill that knocked down a “target symptom” of a “discrete disease.” The six-week “clinical trial” would prove that this was the right thing to do. However, this tool wouldn’t provide any insight into how patients were faring over the long term. Were they able to work? Were they enjoying life? Did they have friends? Were they getting married? None of those questions would be answered. This was the moment that magic-bullet medicine shaped psychiatry’s future. The use of the clinical trial would cause psychiatrists to see their therapies through a very particular prism, and even at the 1956 conference, New York State Psychiatric Institute researcher Joseph Zubin warned that when it came to evaluating a therapy for a psychiatric disorder, a six-week study induced a kind of scientific myopia. “It would be foolhardy to claim a definite advantage for a specified therapy without a two- to five-year follow-up,” he said. “A two-year follow-up would seem to be the very minimum for the long-term effects.

Unfortunately, just like many pets that have been infected with giardia, my son has had a life-long battle with bowel issues including bacterial overgrowth.

To make things even more challenging, cells must also be able to make all of their component molecular machines using only the resources that are available in the local environment. Think of the magnitude of this accomplishment. Many bacteria are able to build all of their own molecules from the a few simple raw materials like carbon dioxide, oxygen, and ammonia. A single bacterial cell knows how to build several thousand types of proteins, including motors, girders, toxins, catalysts, and construction machinery. This cell also builds hundreds of RNA molecules with different orderings of nucleotides, as well as a diverse collection of lipids, sugar polymers, and a bewildering collection of exotic small molecules. All of these different molecules must be created from scratch, using only the molecules that the cell eats, drinks, and breathes.

Even symbionts as essential and long-standing as mitochondria, the energy-providing power plants that exist in all animals, cells, can wreak havoc if they end up in the wrong place. A cut or a bruise can split some of your cells apart and spill fragments of mitochondria into your blood – fragments that still keep some of their ancient bacterial character. When your immune system spots them, it mistakenly assumes that an infection is under way and mounts a strong defence.

all human gynecological practices have some very basic things in common: They try to preserve the life of the mother and, if possible, the child. They try to prevent and treat excessive uterine bleeding. They try to prevent and treat bacterial infection.[*6] They tend to guide the intensity of the mother’s labor efforts to coincide with the dilation of her cervix.

One bacterial species stood out, both for its protective powers and for its colour: blackish-purple, ominous but darkly beautiful. It was called Janthinobacterium lividum. Everyone just refers to it as J-liv.

At the time, BD was creeping fast across the Sierra Nevada, covering around 700 metres a year. By charting its advances, Vredenburg predicted that it would next hit Dusy Basin, a site some 11,000 feet above sea level, where thousands of yellow-legged frogs remained oblivious to the encroaching doom. It was the perfect place to put J-liv's powers to the test. In 2010, Vredenburg and his team hiked to Dusy Basin and grabbed every frog they could find. They found J-liv on the skin of one individual, and grew it into rich, thriving cultures. They then baptised some of the other captured individuals in this bacterial broth. The rest, they left in containers that just had pond water. After a few hours, they released all the frogs to fate and fungus. "The results were phenomenal," says Vredenburg. As predicted, Bd arrived that summer. The fungus took its usual toll on the frogs that had just been soaked in pond water-dozens of spores became thousands of spores, and each frog became an ex-frog. But in the animals that were dunked in J-liv, the fatal accumulation of spores not only plateaued early, it often reversed. A year later, around 39 percent of them were still alive, while their peers were all dead. The trial had worked. The team had successfully protected a wild population of vulnerable frogs with a microbe. And they had established J-liv as a probiotic: a term that is most commonly linked to yoghurts and supplements, but really applies to any microbe that can be applied to a host to improve its health.

The data might tell tales with preposterous plots, but they don't lie. They tell us that the citrus mealybug is a mash-up of at least six different species, five of which are bacterial and three of which aren't even there. It uses genes borrowed from former symbionts to control, cement, and complement the relationship between its two current ones, one of which lives inside the other.

When Hamiltonella's genome was sequenced, the real reason behind the bacterium's protective powers became apparent: about half of its DNA actually belonged to a virus. It was a phage - one of those spindly-legged, mucus-loving viruses that we met before. They typically kill bacteria by reproducing inside them and bursting fatally outward. But they can also opt for a more passive lifestyle, where they integrate their DNA into a bacterium's genome and stay there for many generations. Dozens of these phages now hide within Hamiltonella. The viruses are Hamiltonella's fists; they give the bacterial bodyguard its punch. Oliver showed that when Hamiltonella carries a particular phage strain, it renders aphids almost totally wasp-proof. If the virus disappeared, the same bacterium became useless, and almost all of its aphid hosts succumbed to their parasites. Without the phage, Hamiltonella might as well have been completely absent for all the good it did. The phages could be poisoning the wasps directly: they certainly mass-produce toxins that can attack animal cells, but don't seem to harm the aphids. Alternatively, they could split Hamiltonella apart, causing the bacteria's own toxins to spill onto the wasps. Or maybe the viral and bacterial chemicals are working together. Whatever the case, it is clear that an insect, a bacterium, and a virus have formed an evolutionary alliance against a parasitic wasp that threatens them all.

Sixty years on, we know that HGT is one of the most profound aspects of bacterial life. It allows bacteria to evolve at blistering speeds. When they face new challenges, they don't have to wait for the right mutations to slowly amass within their existing DNA. They can just borrow adaptations wholesale, by picking up genes from bystanders that have already adapted to the challenges at hand. These genes often include dining sets for breaking down untapped sources of energy, shields that protect against antibiotics, or arsenals for infecting new hosts. If an innovative bacterium evolves one of these genetic tools, its neighbours can quickly obtain the same traits. This process can instantly change microbes from harmless gut residents into disease-causing monsters, from peaceful Jekylls into sinister Hydes. They can also transform vulnerable pathogens that are easy to kill into nightmarish 'superbugs' that shrug off even our most potent medicines. The spread of these antibiotic-resistant bacteria is undoubtedly one of the greatest public health threats of the twenty-first century, and it is testament to the unbridled power of HGT.

John McCutcheon has worked out the origins of this weird hierarchy-and it's almost unbelievable in its twists and turns. It begins with Tremblaya, the first of the two bacteria to colonise mealybugs. It became a permanent resident and, like many insect symbionts, it lost genes that were important for a free-living existence. In the cosy confines of its new host, it could afford to get by with a more streamline genome. When Moranella joined this two-way symbiosis, Tremblaya could afford to lose even more genes, in the surety that the new arrival would pick up the slack. As long as a gene exists in one of the partners, the others can afford to lose it. These types of gene transfer are different to those that turned nematodes, into plant parasites, or those that sprinkled antibiotic genes into tick genomes. Here, the recipients don't gain beneficial abilities. Here, HGT is more about evacuating bacterial genes from a capsizing ship. It preserves genes that would otherwise be lost to the inevitable decay that afflicts symbiont genomes.

In spite of the weakness of the epidemiological evidence linking nitrites to cancer, and the established fact that 95 per cent of all the nitrite we ingest comes from bacterial conversion of nitrates naturally found in vegetables, many consumers have a lingering concern about eating nitrite-cured processed meats. But one person’s concern is another’s business opportunity.

Despite the illusion imparted by a diagnosis, people do not usually “have” an emotional issue in the sense of having a cold or a bacterial infection.8 Unlike medical diagnoses, few psychiatric diagnoses describe an underlying cause with a clearly useful course of treatment or a reliable prognosis. Depression, as one example, is not something people have, it is an experience, a way of experiencing oneself and the world. Some people characteristically—or in the shorter term, in an acute response to life events—have depressed feelings and sometimes live out the feelings in ways that are problematic and self-perpetuating.

Where do these underarm odors come from? We can blame bacteria that inhabit the surface of our skin. There are millions of them, and they feed on us. Indirectly. Our apocrine sweat glands, which are mostly found in our armpits and private regions, produce a yellowish fluid that harbors fats, proteins, and various steroids. The fluid has no smell, but its components are great food for bacteria. As they digest these components, the bacteria produce a variety of malodorous compounds. To put it bluntly, unless we take care, we’ll end up reeking of bacterial poop.

Findings have become common on brain-like processes outside of the skull. The conductive structure inside the heart, like pacemaker cells, which organizes the heartbeat, can be known as the brain of the heart, just as the intestine's brain is the ganglion cells in the gut. Conduction system independence is shown when a transplanted heart continues to beat even though the nerves that connected it to the central and peripheral nervous systems of the donor have been severed. The interaction between the independent processing of the heart and that of the brain is complex and not fully understood. The trillions of bacteria that outnumber the cells of the body by ten to one are even more enigmatic, residing mostly within the digestive tract but also on the skin and in the brain and other organs. We think of these bacteria as pests, but these micro-organisms were simply introduced in vast stretches along the double helix of human DNA over eons. The consequences are immense and essentially uncharted for what we call "being alive" The bacterial part of the body, taken as a whole, is called the microbiome. It is not sitting on the skin or in the gut passively, nor is it invading the body. Actually, the microbiota is the barrier between "in here" and "out there," containing DNA, antibodies, and chemical signaling that allows the brain to do the same stuff. There is no clear role of the microbial DNA that is incorporated into our genomes, but at least this is ancestral material that we have assimilated as our own. More suggestively, this once-foreign DNA in all higher life-forms may be the swapping mechanism for genes. These discoveries demonstrate that our intelligence extends to the whole of ecology. Everywhere mentality has a physical basis. Any attempt at isolating it in the skull comes up against serious objections. Instead of treating cynicism with unbounded consciousness, we need to see that every perception is unbounded. By going beyond the illusory boundaries of the disconnected body, you cannot see, hear or touch anything in the universe. Watching a sunset is like watching yourself, actually.

Who would you be if you had somehow avoided every tenacious impediment in the invisible bacterial obstacle course of your daily life? Or what if, through some miracle of science...there was a way to cleanse the detritus that has cumulatively contaminated your genes since before you were even born? Who would you be today? Would you be the same person; the same unique individual? Or would you be something more?

Our culture is also built on something no bacterium or chimp can conceive. It’s built on an ancestor worship that keeps our ancient trail of insights alive for hundreds of generations and passes them down the line. We worship ancestors more than we know. In science, we invoke their names to validate our scientific claims. We refer to Plato, Aristotle, Newton, Darwin, and Einstein. [...] In political life, we invoke our founding fathers [...]. Islam invokes the memory of Mohammed and has produced tens of thousands of pages recording nearly every moment of his life. Buddhism is built on the memory of Siddhartha Gautama, the Buddha. And antiglobalism and anticapitalism keep alive the spirit of the French Revolution, Karl Marx, and Michele Foucault. The result is a layer-upon-layer crepe-cake of thought-tools that accumulates the way that bacterial stromatolites rise from the bottom of the sea and reach for the sky. But this multilayered monument exists in imagination and achievement. It exists as a product of human minds.

In our solar system life first evolved surprisingly soon after the formation of a hospitable terrestrial environment. There is something unusual about this. Suppose the typical time that it takes for life to evolve is called t(bio), then from the evidence of our solar system, which is about 4.6 billion years old, it seems that the time it takes for stars to settle down and create a stable source of heat and light, t(star), is not very different to t(bio) because we have found simple forms of terrestrial bacterial life that are several billion years old.

In a short time, we had constructed and validated a new technology that, based on the body of research conducted with ZFN and TALEN proteins, would be capable of editing the genome—any genome, not just one belonging to a bacterial virus. Out of this fifth bacterial weapons system, we had built the means to rewrite the code of life.

It is their job to read our blood pressure, change our sheets, wash our clothes, clean our toilets, take our blood, change our diapers, clean our asses, cover our wounds, deliver our meds, serve our food, forge our prescriptions (there are no permanent doctors on staff), turn on our TV, take our temperatures, and diagnose viral versus bacterial infections in order to determine antibiotic needs.

Is it in working condition? Is it expired? Old cosmetics provide havens for bacterial growth and can become health hazards, just as combs with missing teeth can hurt your hair. Recycle the former through the Return to Origins Recycling Program (at any Origins location; see Resources) and the latter with your number 1 plastics

Got Milk? For the record, you shouldn’t. I am not advocating for training your gut to handle lactose. We learned about the effect of animal protein and saturated fat on the gut in Chapter 2—less SCFA-producing bacteria, more inflammatory bacteria, increased TMAO production, increased intestinal permeability, and increases in bacterial endotoxin. As we’ve done in the past, when we examine the whole food rather than a sum of its parts, we find that dairy products have been associated with prostate cancer and Parkinson’s disease. Also the link to bone health turns out to be a myth—a prospective study of ninety-six thousand people over twenty-two years showed that milk consumption during teenage years did not protect against hip fracture later in life. In fact, men who drank more milk as a teenager actually had increased risk of hip fracture in the study. In a study of women in Sweden, high milk intake was associated with increased risk of bone fracture, heart disease, cancer, and premature death. One of the first things I do with my patients who have gas, bloating, or diarrhea is to eliminate dairy. You would not believe how many of them are cured just by doing this. Sorry, but milk doesn’t do a body good. The irony is that lactose, which has been vilified through the years as evil, is probably the most redeeming thing about dairy because lactose is actually a prebiotic and can have a beneficial effect on the gut microbiota.