Acute Depression Quotes

Om began to feel the acute depression that steals over every realist in the presence of an optimist.

Huston Smith, the scholar of religion, once described a spiritually “realized being” as simply a person with “an acute sense of the astonishing mystery of everything.

It is too often the quality of happiness that you feel at every moment its fragility, while depression seems when you are in it to be a state that will never pass. Even if you accept that moods change, that whatever you feel today will be different tomorrow, you cannot relax into happiness like you can into sadness. For me, sadness has always been and still is a more powerful feeling; and if that is not a universal experience, perhaps it is the base from which depression grows. I hated being depressed, but it was also in depression that I learned my own acreage, the full extent of my soul. When I am happy, I feel slightly distracted by happiness, as though it fails to use some part of my mind and brain that wants the exercise. Depression is something to do. My grasp tightens and becomes acute in moments of loss: I can see the beauty of glass objects fully at the moment when they slip from my hand toward the floor.

In addition, if a person makes the error of identifying self with his work (rather than with the internal virtues that make the work possible), if self-esteem is tied primarily to accomplishments, success, income, or being a good family provider, the danger is that economic circumstances beyond the individual’s control may lead to the failure of the business or the loss of a job, flinging him into depression or acute demoralization.

But day after day of depression, the kind that doesn’t seem to merit carting me off to a hospital but allows me to sit here on this stoop in summer camp as if I were normal, day after day wearing down everybody who gets near me. My behavior seems, somehow, not acute enough for them to know what to do with me, though I’m just enough of a mess to be driving everyone around me crazy.

Something was not dead within me, in the depths of my heart and conscience it would not die, and it showed itself in acute depression.

A small insect, clearly suffering from acute depression, decided that my open mouth was the ideal route for a suicide mission. With kamikaze-like determination, it rocketed down my throat and splattered against my tonsils. - Calma Harrison

Despair, grief, and depression are not things that people can simply stop, any more than someone can will an end to a toothache or the pain of withdrawal. Acutely suicidal people have lost all sense of having power over their pain. To tell them to magically acquire will power is like asking a crippled person to race against a champion. It does not help them do the thing in question; it just makes them feel worse.

In the first place I spent most of my time at home, reading. I tried to stifle all that was continually seething within me by means of external impressions. And the only external means I had was reading. Reading, of course, was a great help--exciting me, giving me pleasure and pain. But at times it bored me fearfully. One longed for movement in spite of everything, and I plunged all at once into dark, underground, loathsome vice of the pettiest kind. My wretched passions were acute, smarting, from my continual, sickly irritability I had hysterical impulses, with tears and convulsions. I had no resource except reading, that is, there was nothing in my surroundings which I could respect and which attracted me. I was overwhelmed with depression, too; I had an hysterical craving for incongruity and for contrast, and so I took to vice. I have not said all this to justify myself .... But, no! I am lying. I did want to justify myself. I make that little observation for my own benefit, gentlemen. I don't want to lie. I vowed to myself I would not.

My wretched passions were acute, smarting, from my continual, sickly irritability I had hysterical impulses, with tears and convulsions. I had no resource except reading, that is, there was nothing in my surroundings which I could respect and which attracted me. I was overwhelmed with depression, too; I had an hysterical craving for incongruity and for contrast, and so I took to vice.

ECassChoosesPikachu: I’m not crying, I just have onions, pepper spray, and severe acute depression in my eye. SeanCassinova: See you after work, I’ll be the bloke holding the sign: Free Hugs

There is no doubt that as one nears the penultimate depths of depression—which is to say just before the stage when one begins to act out one’s suicide instead of being a mere contemplator of it—the acute sense of loss is connected with a knowledge of life slipping away at accelerated speed. One develops fierce attachments. Ludicrous things—my reading glasses, a handkerchief, a certain writing instrument—became the objects of my demented possessiveness. Each momentary misplacement filled me with a frenzied dismay, each item being the tactile reminder of a world soon to be obliterated.

[If there was] certainty that an acute episode [of depression] will last only a week, a month, even a year, it would change everything. It would still be a ghastly ordeal, but the worst thing about it — the incessant yearning for death, the compulsion toward suicide — would drop away. But no, a limited depression, a depression with hope, is a contradiction. The experience of convulsive pain, along with the conviction that it will never end except in death — that is the definition of a severe depression.

As it happens I am comfortable with the Michael Laskis of this world, with those who live outside rather than in, those in whom the sense of dread is so acute that they turn to extreme and doomed commitments; I know something about dread myself, and appreciate the elaborate systems with which some people manage to fill the void, appreciate all the opiates of the people, whether they are as accessible as alcohol and heroin and promiscuity or as hard to come by as faith in God or History. But of course I did not mention dread to Michael Laski, whose particular opiate is History. I did suggest “depression,” did venture that it might have been “depressing” for him to see only a dozen or so faces at his last May Day demonstration, but he told me that depression was an impediment to the revolutionary process, a disease afflicting only those who do not have ideology to sustain them.

Becoming acutely lonely, the experiment found, was as stressful as experiencing a physical attack.

The artistic life is a long and lovely suicide precisely because it involves the negation of self; as Highsmith imagined herself as her characters, so Ripley takes on the personae of others and in doing so metamorphoses himself into a 'living' work of art. A return to the 'real life' after a period of creativity resulted in a fall in spirits, an agony Highsmith felt acutely. She voiced this pain in the novel via Bernard's quotation of an excerpt from Derwatt's notebook: 'There is no depression for the artist except that caused by a return to the self'.

It ended by my almost believing (perhaps actually believing) that this was perhaps my normal condition. But at first, in the beginning, what agonies I endured in that struggle! I did not believe it was the same with other people, and all my life I hid this fact about myself as a secret. I was ashamed (even now, perhaps, I am ashamed): I got to the point of feeling a sort of secret abnormal, despicable enjoyment in returning home to my corner on some disgusting Petersburg night, acutely conscious that that day I had committed a loathsome action again, that what was done could never be undone, and secretly, inwardly gnawing, gnawing at myself for it, tearing and consuming myself till at last the bitterness turned into a sort of shameful accursed sweetness, and at last—into positive real enjoyment! Yes, into enjoyment, into enjoyment! I insist upon that. I have spoken of this because I keep wanting to know for a fact whether other people feel such enjoyment? I will explain; the enjoyment was just from the too intense consciousness of one’s own degradation; it was from feeling oneself that one had reached the last barrier, that it was horrible, but that it could not be otherwise; that there was no escape for you; that you never could become a different man; that even if time and faith were still left you to change into something different you would most likely not wish to change; or if you did wish to, even then you would do nothing; because perhaps in reality there was nothing for you to change into. And the worst of it was, and the root of it all, that it was all in accord with the normal fundamental laws of over-acute consciousness, and with the inertia that was the direct result of those laws, and that consequently one was not only unable to change but could do absolutely nothing. Thus it would follow, as the result of acute consciousness, that one is not to blame in being a scoundrel; as though that were any consolation to the scoundrel once he has come to realise that he actually is a scoundrel.

Consider the hypothetical case of a man who can have anything he wants just by wishing for it. Such a man has power, but he will develop serious psychological problems. At first he will have a lot of fun, but by and by he will become acutely bored and demoralized. Eventually he may become clinically depressed. History shows that leisured aristocracies tend to become decadent. This is not true of fighting aristocracies that have to struggle to maintain their power. But leisured, secure aristocracies that have no need to exert themselves usually become bored, hedonistic and demoralized, even though they have power. This shows that power is not enough. One must have goals toward which to exercise one's power.

It’s normally agreed that the question “How are you?” doesn’t put you on your oath to give a full or honest answer. So when asked these days, I tend to say something cryptic like, “A bit early to say.” (If it’s the wonderful staff at my oncology clinic who inquire, I sometimes go so far as to respond, “I seem to have cancer today.”) Nobody wants to be told about the countless minor horrors and humiliations that become facts of “life” when your body turns from being a friend to being a foe: the boring switch from chronic constipation to its sudden dramatic opposite; the equally nasty double cross of feeling acute hunger while fearing even the scent of food; the absolute misery of gut–wringing nausea on an utterly empty stomach; or the pathetic discovery that hair loss extends to the disappearance of the follicles in your nostrils, and thus to the childish and irritating phenomenon of a permanently runny nose. Sorry, but you did ask... It’s no fun to appreciate to the full the truth of the materialist proposition that I don’t have a body, I am a body. But it’s not really possible to adopt a stance of “Don’t ask, don’t tell,” either. Like its original, this is a prescription for hypocrisy and double standards. Friends and relatives, obviously, don’t really have the option of not making kind inquiries. One way of trying to put them at their ease is to be as candid as possible and not to adopt any sort of euphemism or denial. The swiftest way of doing this is to note that the thing about Stage Four is that there is no such thing as Stage Five. Quite rightly, some take me up on it. I recently had to accept that I wasn’t going to be able to attend my niece’s wedding, in my old hometown and former university in Oxford. This depressed me for more than one reason, and an especially close friend inquired, “Is it that you’re afraid you’ll never see England again?” As it happens he was exactly right to ask, and it had been precisely that which had been bothering me, but I was unreasonably shocked by his bluntness. I’ll do the facing of hard facts, thanks. Don’t you be doing it too. And yet I had absolutely invited the question. Telling someone else, with deliberate realism, that once I’d had a few more scans and treatments I might be told by the doctors that things from now on could be mainly a matter of “management,” I again had the wind knocked out of me when she said, “Yes, I suppose a time comes when you have to consider letting go.” How true, and how crisp a summary of what I had just said myself. But again there was the unreasonable urge to have a kind of monopoly on, or a sort of veto over, what was actually sayable. Cancer victimhood contains a permanent temptation to be self–centered and even solipsistic.

Way back when I was four, I became increasingly sickly and spiritless. My mother took me to the doctor, who poked and prodded and deliberated. In the end, he pronounced, "She's depressed." Depressed at four years old. Why? No one had an answer....I have long evaded the real reasons for my discontentment. I still can't tell what they are, precisely, but I feel their presence most acutely in moments like this one with my grandmother, imagining a day in a big-box store that had replaced an old farm.

You must watch and observe your friends and family around you. Offer love and support to those who may suffer from acute depression. Depression is one of the most common mental disorders affecting approximately 350 million people all over the world. No person can ever be immune to this mental problem. I have suffered from depression in my life. So, I know the signs pretty well. Approximately one in four women and one in ten men suffer from depression in their lifetime. We need to help and support those who may need it the most

This feeling of stress triggers a cascade of physiological consequences. The hypothalamus and pituitary gland in the brain release hormones that cause the release of cortisol from the adrenal glands located on the kidneys. Cortisol increases heart rate, among other things, readying the body for “fight” or “flight.” Acutely, the release of cortisol is beneficial and helps you cope with whatever is urgently being demanded of you. But if the stress becomes chronic, maladaptive things begin to happen. Normally, the release of cortisol turns the hypothalamus and pituitary off, stopping the release of hormone, which in turn stops the further release of cortisol from the adrenal glands. It’s a nice, clean, negative feedback loop. But in the chronically stressed, the loop breaks. The brain stops reacting to cortisol. Our natural, automatic shutoff valve stops working. The brain keeps releasing hormone, and the adrenal glands keep dumping cortisol into the bloodstream, even when the stressful thing that initially triggered the stress response is no longer around. Chronic, elevated levels of cortisol have been associated with a weakened immune system, deficits in short-term memory, chronic fatigue syndrome, anxiety disorders, and depression.

Some mass murderers, so deeply depressed, become schizophrenic or psychotic. Others suffer with severe anxiety and personality disorders. These are not rational people at the time of the murders even when their behaviors are calculated and decisive. Many of them are not legally insane but suffer from severe psychological dysfunctioning as a result of both chronic and acute stress.

PERIODIC MOOD-CHANGES We have already spoken of the affective concomitants of common migraines—elated and irritable prodromal states, states of dread and depression associated with the main phase of the attack, and states of euphoric rebound. Any or all of these may be abstracted as isolated periodic symptoms of relatively short duration—some hours, or at most two or three days, and as such may present themselves as primary emotional disorders. The most acute of these mood-changes, generally no more than an hour in duration, usually represents concomitants or equivalents of migraine aura. We may confine our attention at this stage to attacks of depression, or truncated manic-depressive cycles, occurring at intervals in patients who have previously suffered from attacks of undoubted (classical, common, abdominal, etc.) migraine.

No doubt you will be delighted to hear from an adept who has undertaken the operation of his H.G.A. in accord with our traditions. The operation began auspiciously with a chromatic display of psychosomatic symptoms, and progressed rapidly to acute psychosis. The operator has alternated satisfactorily between manic hysteria and depressing melancholy stupor on approximately 40 cycles, and satisfactory progress has been maintained in social ostracism, economic collapses and mental disassociation. These statements are mentioned not in any vainglorious spirit of conceit, but rather that they may serve as comfort and inspiration to other aspirants on the Path. Now I'm off to the wilds of Mexico for a period, also in pursuit of the elusive H.G.A. before winding up in the guard finally via the booby hotels, the graveyard, or—? If the final, you can tell all the little Practicuses that I wouldn't have missed it for anything. —No one. Once called 210

Soranus of Ephesus (AD 98–138) seems to have discovered lithium as a cure for manic depression by recommending that severely disturbed patients be treated with the alkaline waters of the town, which contained high levels of lithium salts. A more radical approach consisted of a pioneering form of electric shock treatment: the Greeks used the ‘electric torpedo’, or eels, as a cure for headaches, believing that ‘the touch of a living torpedo stupefied or blunted the acute sense of pain’. An oil was prepared from the dead fish for use when no live ones were available.

Depression is hard to understand, because it is not a consistent state. Depression is rather like a virus, but like a virus, it has its manageable days and its acute, life-threatening flare-ups. You can be in a depression and still laugh at a friend’s joke or have a good night at dinner or manage low-level functioning. You grocery shop and stop to pet a puppy on the corner, talk to friends in a café, maybe write something you don’t hate. When this happens, you might examine your day for clues like reading tea leaves in a cup: Was it the egg for breakfast that made the difference? The three-mile run? You think, well, maybe this thing has moved on now. And you make no sudden moves for fear of attracting its abusive attention again. But other times… Other times, it’s as if a hole is opening inside you, wider and wider, pressing against your lungs, pushing your internal organs into unnatural places, and you cannot draw a true breath. You are breaking inside, slowly, and everything that keeps you tethered to your life, all of your normal responses, is being sucked through the hole like an airlock emptying into space. These are the times Holly Golightly called the Mean Reds. I call it White Knuckling it.

Mental illness—having it, advocating for its understanding, living with it—has an image problem. A large part of the problem, I think, is the term itself—illness is something that automatically suggests rot and contagion, a short interim of bodily collapse that must and can be cured as quickly as possible. But the spectrum of mental disorders—which runs from low-grade depression to personality disorders to acute schizophrenia—suggests that this term is far from sufficient. It is far too restrictive. It suggests two states, and only two states: healthy and sick, well and unwell. But the truth is many people who live with mental illness are well and sick

The problem is particularly acute for teenagers because their circadian cycles can be up to two hours adrift from those of their elders, turning them into comparative night owls. When a teenager struggles to get up in the morning, that isn’t laziness; it’s biology. Matters are compounded in America by what The New York Times in an editorial called “a dangerous tradition: starting high school abnormally early.” According to the Times, 86 percent of U.S. high schools start their day before 8:30 a.m., and 10 percent start before 7:30. Later start times have been shown to produce better attendance, better test results, fewer car accidents, and even less depression and self-harm.

About his madmen Mr. Lecky was no more certain. He knew less than the little to be learned of the causes or even of the results of madness. Yet for practical purposes one can imagine all that is necessary. As long as maniacs walk like men, you must come close to them to penetrate so excellent a disguise. Once close, you have joined the true werewolf. Pick for your companion a manic-depressive, afflicted by any of the various degrees of mania - chronic, acute, delirious. Usually more man than wolf, he will be instructive. His disorder lies in the very process of his thinking, rather than in the content of his thought. He cannot wait a minute for the satisfaction of his fleeting desires or the fulfillment of his innumerable schemes. Nor can he, for two minutes, be certain of his intention or constant in any plan or agreement. Presently you may hear his failing made manifest in the crazy concatenation of his thinking aloud, which psychiatrists call "flight of ideas." Exhausted suddenly by this riotous expense of speech and spirit, he may subside in an apathy dangerous and morose, which you will be well advised not to disturb. Let the man you meet be, instead, a paretic. He has taken a secret departure from your world. He dwells amidst choicest, most dispendious superlatives. In his arm he has the strength to lift ten elephants. He is already two hundred years old. He is more than nine feet high; his chest is of iron, his right leg is silver, his incomparable head is one whole ruby. Husband of a thousand wives, he has begotten on them ten thousand children. Nothing is mean about him; his urine is white wine; his faeces are always soft gold. However, despite his splendor and his extraordinary attainments, he cannot successfully pronounce the words: electricity, Methodist Episcopal, organization, third cavalry brigade. Avoid them. Infuriated by your demonstration of any accomplishment not his, he may suddenly kill you. Now choose for your friend a paranoiac, and beware of the wolf! His back is to the wall, his implacable enemies are crowding on him. He gets no rest. He finds no starting hole to hide him. Ten times oftener than the Apostle, he has been, through the violence of the unswerving malice which pursues him, in perils of waters, in perils of robbers, in perils of his own countrymen, in perils by the heathen, in perils in the city, in perils in the wilderness, in perils in the sea, in perils among false brethren, in weariness and painfulness, in watchings often, in hunger and thirst, in fastings often, in cold and nakedness. Now that, face to face with him, you simulate innocence and come within his reach, what pity can you expect? You showed him none; he will certainly not show you any. Lighten our darkness, we beseech thee, 0 Lord; and by thy great mercy defend us from all the perils and dangers of this night; for the love of thy only Son, our Saviour, Jesus Christ. Amen. Mr. Lecky's maniacs lay in wait to slash a man's head half off, to perform some erotic atrocity of disembowelment on a woman. Here, they fed thoughtlessly on human flesh; there, wishing to play with him, they plucked the mangled Tybalt from his shroud. The beastly cunning of their approach, the fantastic capriciousness of their intention could not be very well met or provided for. In his makeshift fort everywhere encircled by darkness, Mr. Lecky did not care to meditate further on the subject.

ME/CFS has a greater negative impact on functional status and well-being than other chronic diseases, e.g., cancer or lung diseases[8], and is associated with a drastic decrement in physical functioning[9]. In a comparison study[10] ME/CFS patients scored significantly lower than patients with hypertension, congestive heart failure, acute myocardial infarction, and multiple sclerosis (MS), on all of the eight Short Form Health Survey (SF-36)[11] subscales. As compared to patients with depression, ME/CFS patients scored significantly lower on all the scales, except for scales measuring mental health and role disability due to emotional problems, on which they scored significantly higher.

A person who is brilliantly talented and successful at work but irrational and irresponsible in his or her private life may want to believe that the sole criterion of virtue is productive performance and that no other sphere of action has moral or self-esteem significance. Such a person may hide behind work in order to evade feelings of shame and guilt stemming from other areas of life (or from painful childhood experiences), so that productive work becomes not so much a healthy passion as an avoidance strategy, a refuge from realities one feels frightened to face. In addition, if a person makes the error of identifying self with his work (rather than with the internal virtues that make the work possible), if self-esteem is tied primarily to accomplishments, success, income, or being a good family provider, the danger is that economic circumstances beyond the individual’s control may lead to the failure of the business or the loss of a job, flinging him into depression or acute demoralization.

During a recent lunch with a close friend who is also the mother of two young children, Diana told of an incident which underlines not only the current state of her relationship with her husband but also the protective nature of her son William. She told her friend that the week that Buckingham Palace decided to announce the separation of the Duke and Duchess of York was understandably a trying time for her. She had lost an amicable companion and was acutely aware that the public spotlight would once again fall on her marriage. Yet her husband seemed unmoved by the furore surrounding the separation. He had spent a week touring various stately homes, gathering material for a book he is writing on gardening. When he returned to Kensington Palace he failed to see why his wife should feel strained and rather depressed. He airily dismissed the departure of the Duchess of York and launched, as usual, into a disapproving appraisal of Diana’s public works, especially her visit to see Mother Teresa in Rome. Even their staff, by now used to these altercations, were dismayed by this attitude and felt some sympathy when Diana told her husband that unless he changed his attitude towards her and the job she is doing she would have to reconsider her position. In tears, she went upstairs for a bath. While she was regaining her composure, Prince William pushed a handful of paper tissues underneath the bathroom door. “I hate to see you sad,” he said.

For many, an explosion of mental problems occurred during the first months of the pandemic and will continue to progress in the post-pandemic era. In March 2020 (at the onset of the pandemic), a group of researchers published a study in The Lancet that found that confinement measures produced a range of severe mental health outcomes, such as trauma, confusion and anger.[153] Although avoiding the most severe mental health issues, a large portion of the world population is bound to have suffered stress to various degrees. First and foremost, it is among those already prone to mental health issues that the challenges inherent in the response to the coronavirus (lockdowns, isolation, anguish) will be exacerbated. Some will weather the storm, but for certain individuals, a diagnostic of depression or anxiety could escalate into an acute clinical episode. There are also significant numbers of people who for the first time presented symptoms of serious mood disorder like mania, signs of depression and various psychotic experiences. These were all triggered by events directly or indirectly associated with the pandemic and the lockdowns, such as isolation and loneliness, fear of catching the disease, losing a job, bereavement and concerns about family members and friends. In May 2020, the National Health Service England’s clinical director for mental health told a Parliamentary committee that the “demand for mental healthcare would increase ‘significantly’ once the lockdown ended and would see people needing treatment for trauma for years to come”.[154] There is no reason to believe that the situation will be very different elsewhere.

The arrival of winter made the matter even more acute, for it multiplied the daily hardships imposed by the German air campaign. Winter brought rain, snow, cold, and wind. Asked by Mass-Observation to keep track of the factors that most depressed them, people replied that weather topped the list. Rain dripped through roofs pierced by shrapnel; wind tore past broken windows. There was no glass to repair them. Frequent interruptions in the supply of electricity, fuel, and water left homes without heat and their residents without a means of getting clean each day. People still had to get to work; their children still needed to go to school. Bombs knocked out telephone service for days on end. What most disrupted their lives, however, was the blackout. It made everything harder, especially now, in winter, when England’s northern latitude brought the usual expansion of night. Every December, Mass-Observation also asked its panel of diarists to send in a ranked list of the inconveniences caused by the bombings that most bothered them. The blackout invariably ranked first, with transport second, though these two factors were often linked. Bomb damage turned simple commutes into hours-long ordeals, and forced workers to get up even earlier in the darkness, where they stumbled around by candlelight to prepare for work. Workers raced home at the end of the day to darken their windows before the designated start of the nightly blackout period, a wholly new class of chore. It took time: an estimated half hour each evening—more if you had a lot of windows, and depending on how you went about it. The blackout made the Christmas season even bleaker. Christmas lights were banned. Churches with windows that could not easily be darkened canceled their night services.

It may seem paradoxical to claim that stress, a physiological mechanism vital to life, is a cause of illness. To resolve this apparent contradiction, we must differentiate between acute stress and chronic stress. Acute stress is the immediate, short-term body response to threat. Chronic stress is activation of the stress mechanisms over long periods of time when a person is exposed to stressors that cannot be escaped either because she does not recognize them or because she has no control over them. Discharges of nervous system, hormonal output and immune changes constitute the flight-or-fight reactions that help us survive immediate danger. These biological responses are adaptive in the emergencies for which nature designed them. But the same stress responses, triggered chronically and without resolution, produce harm and even permanent damage. Chronically high cortisol levels destroy tissue. Chronically elevated adrenalin levels raise the blood pressure and damage the heart. There is extensive documentation of the inhibiting effect of chronic stress on the immune system. In one study, the activity of immune cells called natural killer (NK) cells were compared in two groups: spousal caregivers of people with Alzheimer’s disease, and age- and health-matched controls. NK cells are front-line troops in the fight against infections and against cancer, having the capacity to attack invading micro-organisms and to destroy cells with malignant mutations. The NK cell functioning of the caregivers was significantly suppressed, even in those whose spouses had died as long as three years previously. The caregivers who reported lower levels of social support also showed the greatest depression in immune activity — just as the loneliest medical students had the most impaired immune systems under the stress of examinations. Another study of caregivers assessed the efficacy of immunization against influenza. In this study 80 per cent among the non-stressed control group developed immunity against the virus, but only 20 per cent of the Alzheimer caregivers were able to do so. The stress of unremitting caregiving inhibited the immune system and left people susceptible to influenza. Research has also shown stress-related delays in tissue repair. The wounds of Alzheimer caregivers took an average of nine days longer to heal than those of controls. Higher levels of stress cause higher cortisol output via the HPA axis, and cortisol inhibits the activity of the inflammatory cells involved in wound healing. Dental students had a wound deliberately inflicted on their hard palates while they were facing immunology exams and again during vacation. In all of them the wound healed more quickly in the summer. Under stress, their white blood cells produced less of a substance essential to healing. The oft-observed relationship between stress, impaired immunity and illness has given rise to the concept of “diseases of adaptation,” a phrase of Hans Selye’s. The flight-or-fight response, it is argued, was indispensable in an era when early human beings had to confront a natural world of predators and other dangers. In civilized society, however, the flight-fight reaction is triggered in situations where it is neither necessary nor helpful, since we no longer face the same mortal threats to existence. The body’s physiological stress mechanisms are often triggered inappropriately, leading to disease. There is another way to look at it. The flight-or-fight alarm reaction exists today for the same purpose evolution originally assigned to it: to enable us to survive. What has happened is that we have lost touch with the gut feelings designed to be our warning system. The body mounts a stress response, but the mind is unaware of the threat. We keep ourselves in physiologically stressful situations, with only a dim awareness of distress or no awareness at all.

When you’re that depressed, that insanely and utterly depressed that you genuinely believe you’ll suffer that acutely for the rest of your days, life seems to lack all purpose. After all, I figured, what’s the point in working, fighting, striving for a better life if you’re sentenced to one of chronic anguish and despair? There is no better life. There is no life outside of pain. So what’s the point in doing anything but waiting until death finally arrives on your doorstep and whisks you away

Logically, when Maestro Gott some years ago, after an especially cruel critic had compared him to "a zombie who causes acute depression to innocent radio listeners", decided to stop performing in protest, the situation was considered so grave that the Minister of Culture himself went to console the deeply insulted star.

Huston Smith, the scholar of religion, once described a spiritually “realized being” as simply a person with “an acute sense of the astonishing mystery of everything.” Faith need not figure.

An air of malaise had spread through Café Society and quite acutely in her coterie, friends impatient to find their way to the lightness, their place in the sun. The Great Depression cast shadows on the city. The roar of the Twenties had quieted to a soulful cry of the blues.

The Fongnam Massage Therapy has its own massage room equipped with a reclining massage bed and a lounger with footstool. Working long hours in front of a computer can cause stress, muscle strain, injury or pain that can leave you physically, mentally or emotionally exhausted. This can negatively affect your social life as well as your work. As the main benefit of massage is stress reduction, massage therapy can improve and maintain overall health and reduce or prevent the negative effects of stress. It can permanently relieve pain, prevent injury and maintain health. It is an important ingredient for staying healthy physically and mentally as it reduces stress, which is responsible for 90% of all illness and pain. Due to the reflex effects of the autonomic nervous system, massage affects internal organs and areas distant from the treated area. It promotes relaxation, relieves pain, elevates mood and mental clarity. Massage can be used for relaxation or stimulation and can be used for rehabilitation after surgery, injury, or health issues. It improves blood and lymphatic circulation, increases natural killer cells and lymphocytes that destroy cancer cells, improves mood by increasing serotonin and dopamine, and relieves pain by increasing analgesic endorphins. Massage can relax the body, lower blood pressure and heart rate, and reduce stress and depression. It can also provide symptomatic relief from acute and chronic conditions such as headaches, facial pain, carpal tunnel syndrome and arthritis. It realigns and rejuvenates, restoring balance to your body and being so you can face whatever life throws at you at every turn. It promotes digestion, joint mobility, muscle relaxation, relief from spasms and cramps.

I have scarcely felt greater pain in my life” than on learning the news. “And yet,” he added, “there is very little in it, if you will allow no feeling of discouragement to seize, and prey upon you.” He told him to go see Harvard’s president and learn what obstacles he had to overcome, and how to overcome them. “In your temporary failure,” he wrote, “there is no evidence that you may not yet be a better scholar, and a more successful man in the great struggle of life, than many others, who have entered college more easily.” Lincoln said he knew this was true from his own “severe experience.” Indeed, many people of this era sought success in the “great struggle of life,” but there were few who felt the struggle more acutely.

People talk about the stages of grief, but there is a stage of depression—at least for me—where you go from feeling pain so acutely you can’t bear it, to feeling nothing at all. A blessed numbness after debilitating sadness. It’s like laying a thin film of steel over your emotions. So thin it’s diaphanous. You can see everything through it, but nothing actually touches you. I couldn’t feel a thing, but I embraced it because at least I wasn’t feeling pain. At that time, joy didn’t stand a chance, but tonight I feel everything. And it is finally good.

The two sides of this trade-off at the root of mental conflict are supported by genetic studies that have found two global pathways to mental disorders.44,45 One pathway is via internalizing, that is, inhibition, anxiety, self-blame, neurosis, and depression. The other pathway is via externalizing, that is, by pursuing self-interest with little inhibition in ways that often lead to social conflicts and addiction. For the first group of patients, social selection has worked all too well; they are acutely attuned to what others want, and they work hard to please others. For the second group, the tendency to pursue self-interest leaves them with limited moral moorings or committed social support. Most of us muddle along somewhere in between. These two global strategies are closely related to fast and slow life history strategies and their possible relationship to mental disorders.46 Early adversity has been proposed to discount the perceived value of long-term benefits and set behavior to take advantage of opportunities now, even at the expense of long-term relationships.47,48,49 This may help explain the association of early adversity with borderline personality.50

Forgetting the benefits of God is also the mark of the immature Christian, one who lives by his feelings. He is prone to a roller-coaster spiritual life, moving quickly from ecstatic highs to depressing lows. In the high moments, he feels an exhilarating sense of God's presence, but he plunges to despair the moment he senses an acute absence of such feelings.

stupid people trying to manage me sends me into acute depression.

His father’s solicitude and sympathy were round him day and night, and this, in the midst of so much toil, pain, grief, and anxiety of his own, that Norman might well feel overwhelmed with the swelling, inexpressible feelings of grateful affection. How could his father know exactly what he would like—say the very things he was thinking—see that his depression was not wilful repining—find exactly what best soothed him! He wondered, but he could not have said so to any one, only his eye brightened, and, as his sisters remarked, he never seemed half so uncomfortable when papa was in the room. Indeed, the certainty that his father felt the sorrow as acutely as himself, was one reason of his opening to him. He could not feel that his brothers and sisters did so, for, outwardly, their habits were unaltered, their spirits not lowered, their relish for things around much the same as before, and this had given Norman a sense of isolation. With his father it was different. Norman knew he could never appreciate what the bereavement was to him—he saw its traces in almost every word and look, and yet perceived that something sustained and consoled him, though not in the way of forgetfulness.

It is estimated that the financial burden of mental illness worldwide will reach $16 trillion by 2030. The World Health Organization reports that over 300 million people suffer from depression alone, making it the leading cause of disability worldwide. That projection is not only disturbing but emphasizes the need to seek disruptive, innovative approaches to psychiatric disease. Mobilehealth can help fill these needs for at least two reasons: given the number of available mental health professionals, it is virtually impossible for all those in need of those services to be cared for face-to-face, a dilemma that is especially acute in low and middle-income countries. And there is also some evidence to suggest that many patients are more willing to open up about their psychological concerns online during an anonymous consultation. 

An air of malaise had spread through Café Society and quite acutely in her coterie, friends impatient to find their way to the lightness, their place in the sun. The Great Depression cast shadows on the city. The roar of the Twenties had quieted to a soulful cry of the blues.

Would addiction spread further under such a system? The answer seems to be: not much. As we have already seen, most normal people get no kick at all from heroin. Any heroin that got into general circulation would still be competing with drugs of less frightening reputation: alcohol, barbiturates and tranquilizers. Probably, most addict personalities – those who are not of low educational level and not under especially acute stress – would continue to choose these “more acceptable” depressants. And, of course, any decriminalization of addiction could still retain the laws against sale, to discourage any addict from selling part of his day’s ration to a curious non-addict.

Physical effects, both long and short term, include: Racing heart, headache, nausea, muscle tension, fatigue, dry mouth, dizzy feelings, increase in breathing rate, aching muscles, trembling and twitching, sweating, disturbed digestion, immune system suppression and memory issues. Your body was designed to endure brief moments of acute stress, but chronic stress (stress that is ongoing) can start to cause chronic health conditions, like cardiovascular disease, insomnia, hormonal dysregulation and so on. If the ordinary physical experience of stress is prolonged, the physical effects can have consequences in the rest of your life… Mental and psychological effects include: Exhaustion and fatigue, feeling on edge, nervousness, irritability, inability to concentrate, lack of motivation, changes to libido and appetite, nightmares, depression, feeling out of control, apathy and so on. Stress can reinforce negative thinking patterns and harmful self-talk, lower our confidence, and kill our motivation. More alarming than this, overthinking can completely warp your perception of events in time, shaping your personality in ways that mean you are more risk averse, more negatively focused and less resilient. When you’re constantly tuned into Stress FM you are not actually consciously aware and available in the present moment to experience life as it is. You miss out on countless potential feelings of joy, gratitude, connection and creativity because of your relentless focus on what could go wrong, or what has gone wrong. This means you’re less likely to recognize creative solutions to problems, see new opportunities and capitalize on them, or truly appreciate all the things that are going right for you. If you are constantly in a low-level state of fear and worry, every new encounter is going to be interpreted through that filter, and interpreted not for what it is, but for what you’re worried it could be.  Broader social and environmental effects include: Damage to close relationships, poor performance at work, impatience and irritability with others, retreating socially, and engaging in addictive or harmful behaviors. A person who is constantly stressed and anxious starts to lose all meaning and joy in life, stops making plans, cannot act with charity or compassion to others, and loses their passion for life. There is very little spontaneity, humor or irreverence when someone’s mind is too busy catastrophizing, right? As you can imagine, the physical, mental and environmental aspects all interact to create one, unified experience of overthinking and anxiety. For example, if you overthink consistently, your body will be flooded with cortisol and other stress hormones. This can leave you on edge, and in fact cause you to overthink even more, adding to the stress, changing the way you feel about yourself and your life. You might then make bad choices for yourself (staying up late, eating bad food, shutting people out) which reinforce the stress cycle you’re in. You may perform worse at work, procrastinating and inevitably giving yourself more to worry about, and so on…

If you’re wondering which age group is actually the least happy, it’s the twentysomethings. Despite being flush with youthful vigor and opportunity, they are the most depressed and stressed out of any age group. Part of this stems from their own perspective on where they are in the human life cycle—as young adults, with oceans of time in front of them, they are constantly faced with decisions to make about their futures, from who they will be to what they will do. Worse, they’re acutely sensitive to what everyone else thinks about them and their choices.

Yes, something is profoundly off in our lives on this planet today. In fact, many things are acutely amiss: we are living disconnected from our bodies through an education system that primes us for industry; disconnected from our communities thanks to technology and isolated, single-family homes; and disconnected from the environment because of several centuries of science that says nature is a collection of utilitarian resources that will ultimately be successfully dominated by mankind. Furthermore, we are disconnected from our very souls by a dominant belief system that says you are only what you can produce, and disconnected from the mysterious wonder of the human experience by the worship of scientific dogma that says something only exists if we can measure and quantify it.

once described a spiritually “realized being” as simply a person with “an acute sense of the astonishing mystery of everything.

As Ms. Miyamoto probably told you, in the end, rather than death, she chose to start a second life in the city of Sendai. The expression she used when describing her life to me was of “a life that was equal parts remorse and gratitude.” On the one hand, she felt that, having abandoned her husband and son, she’d no right to go on living. On the other hand, she felt acutely grateful that the people she’d encountered in this unfamiliar place were so willing to help. I suspect—and I don’t think I’m imagining things—that the act of leaving home actually helped alleviate the symptoms of her depression.

During the depersonalisation or derealisation experiences, reality testing remains intact. C. The symptoms cause clinically significant distress or impairment in social, occupational, or other important areas of functioning. D. The disturbance is not attributable to the physiological effects of a substance (e.g., a drug of abuse, medication) or other medical condition (e.g., seizures). E. The disturbance is not better explained by another mental disorder, such as schizophrenia, panic disorder, major depressive disorder, acute stress disorder, posttraumatic stress disorder, or another dissociative disorder.

particular, as we progress, we create a degree of stability in our mind so that it becomes less prone to either overexcitement or depression; thus our practice helps protect us from the stress of experiencing too acutely the ups and downs of life. This

[Just as] biodiversity increases resilience to negative events because a single predator cannot wipe out an entire ecosystem, emodiversity may prevent specific emotions—in particular detrimental ones such as acute stress, anger or sadness—from dominating the emotional ecosystem. For instance, the experience of prolonged sadness might lead to depression but the joint experience of sadness and anger—although unpleasant—might prevent individuals from completely withdrawing from their environment. The same biodiversity analogy could be applied to positive emotion. Humans are notoriously quick to adapt to repeated exposure to a given positive emotional experience; positive experiences that are diverse may be more resistant to such extinction.[

Om, bumping along in Brutha’s pack, began to feel the acute depression that steals over every realist in the presence of an optimist.

Unalleviated, Resistance mounts to a pitch that becomes unendurable. At this point vices kick in. Dope, adultery, web surfing. Beyond that, Resistance becomes clinical. Depression, aggression, dysfunction. Then actual crime and physical self-destruction. Sounds like life, I know. It isn’t. It’s Resistance. What makes it tricky is that we live in a consumer culture that’s acutely aware of this unhappiness and has massed all its profit-seeking artillery to exploit it. By selling us a product, a drug, a distraction.

Everyone over a certain (very young) age has endured disillusionment and knows it to be an acutely painful sensation. “Sensation” is not nearly a strong enough word. We’re talking about a pain that can suffuse our very cells and rapidly metastasize into depression; a pain that seems, symptomatically, to have much in common with the knock-out body blow that a jilting, an abandonment, or other rejection can inflict. Perhaps disillusionment is a kind of jilting / rejection? It can leave us feeling we’ve been dropped by the world, existentially dumped; the cherished belief we were embracing like a lover has turned out to be a cheat, a false friend, a zero, and the pain of that epiphany is lonely and isolating.

dysfunction and weight gain. However, the SSRIs are still often preferred because they target common comorbid conditions, such as depression or obsessive-compulsive disorder (OCD). Benzodiazepines and SSRIs can be initiated together to treat acute panic symptoms; use of the benzodiazepine can be tapered after 3 to 4 weeks after the therapeutic benefits of the SSRI have emerged.

This was a moment of deep crisis for him. He had a psychological breakdown, and he was admitted to a psychiatric ward. He was heavily medicated. He contemplated suicide. It was much more than just a legal case for him. He was... extremely humiliated... and I think when he felt betrayed... At his absolute lowest, in 1976, when the tax affair is most acute - in his work diary suddenly he writes: “Wait a minute, I should be able to use this. This is exactly what Abel my character should be feeling. So I can take my own emotions now and try to write them down.” Whether he feels happy or depressed he can use that emotion and turn it into the emotions of one of his fictional characters.

Despite the illusion imparted by a diagnosis, people do not usually “have” an emotional issue in the sense of having a cold or a bacterial infection.8 Unlike medical diagnoses, few psychiatric diagnoses describe an underlying cause with a clearly useful course of treatment or a reliable prognosis. Depression, as one example, is not something people have, it is an experience, a way of experiencing oneself and the world. Some people characteristically—or in the shorter term, in an acute response to life events—have depressed feelings and sometimes live out the feelings in ways that are problematic and self-perpetuating.

It is this acute awareness of transience and limitation that constitutes mild depression.

And what happens when you drop a life-form into an alien environment? NASA scientists wondered the same thing before the first space flights. The human body had been built to thrive under the pressure of gravity, so maybe taking away that pressure would act as an escape-trajectory Fountain of Youth, leaving the astronauts feeling stronger, smarter, and healthier. After all, every calorie they ate would now go toward feeding their brains and bodies, instead of pushing up against that relentless downward pull—right? Not by a long shot; by the time the astronauts returned to earth, they’d aged decades in a matter of days. Their bones were weaker and their muscles had atrophied; they had insomnia, depression, acute fatigue, and listlessness. Even their taste buds had decayed. If you’ve ever spent a long weekend watching TV on the sofa, you know the feeling, because down here on earth, we’ve created our own zero-gravity bubble; we’ve taken away the jobs our bodies were meant to do, and we’re paying for it. Nearly every top killer in the Western world—heart disease, stroke, diabetes, depression, hypertension, and a dozen forms of cancer—was unknown to our ancestors. They didn’t have medicine, but they did have a magic bullet—or maybe two, judging by the number of digits Dr. Bramble was holding up.

She suffers from depression, anxiety, and acute stress. Her depression leaves her with no hope and thoughts of suicide and self-harm. Her anxiety is evidenced by high blood pressure, tense muscles, dizziness, and trembling. She suffers from insomnia one week and then sleeps for hours and hours the next week. She hallucinates, sees things that are not real, and often yells at night when she has nightmares. Her mood swings are extreme, but almost always on the dark side. If she has a good day, one in which she appears somewhat happy, it is almost always followed by two or three days of darkness. At times she is virtually catatonic. She is paranoid and thinks someone is stalking her, or that someone else is in the room. This often leads to panic attacks in which she is stricken with absolute fear and has trouble breathing. These usually pass within an hour or two. She eats little and refuses to take care of herself. Her hygiene is not good.

I’m struck by the fact there was nothing supernatural about my heightened perceptions that afternoon, nothing that I needed an idea of magic or a divinity to explain. No, all it took was another perceptual slant on the same old reality, a lens or mode of consciousness that invented nothing but merely (merely!) italicized the prose of ordinary experience, disclosing the wonder that is always there in a garden or wood, hidden in plain sight—another form of consciousness “parted from [us],” as William James put it, “by the filmiest of screens.” Nature does in fact teem with subjectivities—call them spirits if you like—other than our own; it is only the human ego, with its imagined monopoly on subjectivity, that keeps us from recognizing them all, our kith and kin. In this sense, I guess Paul Stamets is right to think the mushrooms are bringing us messages from nature, or at least helping us to open up and read them. Before this afternoon, I had always assumed access to a spiritual dimension hinged on one’s acceptance of the supernatural—of God, of a Beyond—but now I’m not so sure. The Beyond, whatever it consists of, might not be nearly as far away or inaccessible as we think. Huston Smith, the scholar of religion, once described a spiritually “realized being” as simply a person with “an acute sense of the astonishing mystery of everything.” Faith need not figure. Maybe to be in a garden and feel awe, or wonder, in the presence of an astonishing mystery, is nothing more than a recovery of a misplaced perspective, perhaps the child’s-eye view; maybe we regain it by means of a neurochemical change that disables the filters (of convention, of ego) that prevent us in ordinary hours from seeing what is, like those lovely leaves, staring us in the face. I don’t know. But if those dried-up little scraps of fungus taught me anything, it is that there are other, stranger forms of consciousness available to us, and, whatever they mean, their very existence, to quote William James again, “forbid[s] a premature closing of our accounts with reality.” Open-minded. And bemushroomed. That was me, now, ready to reopen my own accounts with reality.

I find the fact of the past, the reality of time's passage, incredibly difficult. My house is full of books I can't read and records to which I can't listen and photos at which I can't look because they are too strongly associated with the past. When I see friends from college, I try not to talk about college too much because I was so happy then--not necessarily happier than I am now, but with a happiness that was particular and specific in its moods and that will never come again. Those days of young splendour eat at me. I hit walls of past pleasure all the time, and for me past pleasure is much harder to process than past pain. To think of a terrible time that has gone: well, I know that post-traumatic stress is an acute affliction, but for me the traumas of the past are mercifully far away. The pleasures of the past, however, are tough. The memory of the good times with people who are no longer alive, or who are no longer the people they were: that is where I find the worst current pain. Don't make me remember, I say to the detritus of past pleasures. Depression can as easily be the consequence of too much that was joyful as of too much that was horrible. There is such a thing as post-joy stress too. The worst of depression lies in a present moment that cannot escape the past it idealizes or deplores.

I was told by my doctor that I was suffering from both depression and acute anxiety. I had believed that those were separate problems, and that is how they were discussed for the thirteen years I received medical care for them. But I noticed something odd as I did my research. Everything that causes an increase in depression also causes an increase in anxiety, and the other way around. They rise and fall together.

I had been running a mental math equation in my head for a while. News of my death would be devastating for Jill. I knew she loved me. She was a sucker, I thought, for doing so, but apparently it couldn't be helped. To this point, I had believed that the payoff for her devastation in that moment would be the better life she would have without me. It's how I imagined law school works: you go through the hard times to get to better times. On that bridge, the image of Jill receiving this news became more crystalline: phone calls trying to locate me would become increasingly frantic until there was a cop at the door. I knew she was wearing a blue sweater that morning and I knew where she'd be standing when the cops showed up. Her pain, because I loved her, was acute in my imagining. It hurt, and it was nauseating, too. I still believed, at least intellectually, that she'd be better off without me, but how could I enable that horrible moment? How could I bring that cop to the door?

William James is one psychologist who spent a lot of time studying this phenomenon. Much of what he learned is detailed in his book The Varieties of Religious Experience and it is from this work that we can find our first clue as to what leads to a psychological rebirth. According to James there is a certain type of person most susceptible to a rapid personality transformation and it is the type of person most in need of one. Rapid personality transformations do not occur very often to those content with life but instead are more likely to occur to those who have reached the darkest pits of despair. Acute suffering, a prolonged state of depression, a pernicious addiction, or utter disillusionment with life are the fertile soil from which the psychological rebirth is manifested. Or as James wrote: “The securest way to the rapturous sort of happiness of which the twice-born make report has as an historic matter of fact been through a more radical pessimism than anything that we have yet considered.” William James, The Varieties of Religious Experienc

When an experience is an unusually powerful emotional event, there may be a series of reactions. These are both common and normal. Signs and symptoms of critical-incident stress include the following: 1. Physical—enduring fatigue, sleep dysfunction (either needing too much or insomnia), change of appetite (eating too much or too little), gastrointestinal upset, headache, backache, chills, nausea, muscular twitches or tremors, shock-like symptoms (especially in acute stress), hyperactivity, or its opposite, underactivity. 2. Emotional—anger, irritability, fear, grief, anxiety, guilt, depression, feeling overwhelmed, identification with the patient(s) in a rescue, emotional numbness, feelings of helplessness or hopelessness. 3. Cognitive—memory loss, especially anomia (the inability to remember names); inability to attach importance to things other than the incident; concentration problems; loss of attention span; difficulties with calculations, decision-making, and problem-solving; flashbacks; nightmares (especially recurrent ones), amnesia for the event; violent fantasies; confusing the importance of trivial and major tasks.

When John and his colleagues added up the data, they were startled. Feeling lonely, it turned out, caused your cortisol levels to absolutely soar - as much as some of the most disturbing things that can happen to you. Becoming acutely lonely, the experiment found, was as stressful as experiencing a physical attack. It's worth repeating. Being deeply lonely seemed to cause as much stress as being punched by a stranger.

Antidepressants have also been associated with an increased acute risk of suicide in younger patients while they may decrease the risk of suicide in older patients or with longer-term use. Also, all major classes of antidepressants have been associated with unpleasant (and sometimes dangerous) symptoms when they are discontinued abruptly. Discontinuation of antidepressants is associated with relapse and recurrence of MDD (Major Depressive Disorder). In a meta-analysis, this risk was shown to be higher for antidepressants that cause greater disruption to neurotransmitter systems . . . [And] there is a growing body of research suggesting that when they are used in the long term as a maintenance treatment, antidepressants can lose efficacy, and may even result in chronic and treatment-resistant depression. Such reactions may be due to the brain’s attempt to maintain homeostasis and a functioning adaptation in spite of the medication.

More than loving themselves, Narcissists are absorbed with themselves. They feel their own desires so acutely that they can’t pay attention to anything else. Imagine their disorder as a pair of binoculars. Narcissists look at their own needs through the magnifying side, and the rest of the cosmos through the side that makes things small to the point of insignificance. It’s not so much that these vampires think they’re better than other people as that they hardly think of other people at all. Unless they need something. Narcissistic need is tremendous. Just as sharks must continually swim to keep from drowning, Narcissists must constantly demonstrate that they are special, or they will sink like stones to the depths of depression. It may look as if they are trying to demonstrate their worth to other people, but their real audience is themselves. Narcissists are experts at showing off. Everything they do is calculated to make the right impression. Conspicuous consumption is for them what religion is for other people. Narcissists pursue the symbols of wealth, status, and power with a fervor that is almost spiritual. They can talk for hours about objects they own, the great things they’ve done or are going to do, and the famous people they hang out with. Often, they exaggerate shamelessly, even when they have plenty of real achievements they could brag about. Nothing is ever enough for them. That’s why Narcissists want you, or at least your adulation. They’ll try so hard to impress you that it’s easy to believe that you’re actually important to them. This can be a fatal mistake; it’s not you they want, only your worship. They’ll suck that out and throw the rest away. To Narcissistic vampires, the objects, the achievements, and the high regard of other people mean nothing in themselves. They are fuel, like water forced across gills so that oxygen can be extracted. The technical term is Narcissistic supplies. If Narcissists don’t constantly demonstrate their specialness to themselves, they drown.

between a quarter and a half of all those exposed to extreme weather events will experience them as an ongoing negative shock to their mental health. In England, flooding was found to quadruple levels of psychological distress, even among those in an inundated community but not personally affected by the flooding. In the aftermath of Hurricane Katrina, 62 percent of evacuees exceeded the diagnostic threshold for acute stress disorder; in the region as a whole, nearly a third had PTSD. Wildfires, curiously, yielded a lower incidence—just 24 percent of evacuees in the aftermath of one series of California blazes. But a third of those who lived through fire were diagnosed, in its aftermath, with depression.

ADRENAL AND HYPOTHALAMUS GLANDULARS Glandular supplements, also commonly called glandulars, are made from various organs and tissues of mammals. They were used successfully to treat multiple conditions throughout the nineteenth and early twentieth centuries. They have recently been making a comeback, thanks to new science showing their positive effects on damaged tissues and organs by exposing the tissues to growth factors that influence the body’s capacity for self-repair and regeneration. Because glandulars contain a complex array of enzymes, vitamins, fatty acids, amino acids, minerals, and neurotransmitters and a host of nutrients in addition to the tissues within the gland, they are difficult to study in a standardized way. On the other hand, this also makes them a food, and one that we are increasingly finding to be far more beneficial to our physiology than the sum of its parts can convey. Adrenal cortex is most helpful for depressive symptoms in addition to a general adrenal glandular. Adrenals must come from pastured animals. Begin with one twice daily of each. Hypothalamus is a calming glandular that begins to repair the communication between the brain and glands. Take one to four for agitation and acute anxiety along with one twice daily. Over time, you will need less.

The body’s initial response to a noxious local insult is to produce a local inflammatory response with sequestration and activation of white blood cells and the release of a variety of mediators to deal with the primary ‘insult’ and prevent further damage either locally or in distant organs. Normally, a delicate balance is achieved between pro- and anti-inflammatory mediators. However, if the inflammatory response is excessive, local control is lost and a large array of mediators, including prostaglandins, leukotrienes, free oxygen radicals and particularly pro-inflammatory cytokines (p. 72), are released into the circulation. The inflammatory and coagulation cascades are intimately related. The process of blood clotting not only involves platelet activation and fibrin deposition but also causes activation of leucocytes and endothelial cells. Conversely, leucocyte activation induces tissue factor expression and initiates coagulation. Control of the coagulation cascade is achieved through the natural anticoagulants, antithrombin (AT III), activated protein C (APC) and tissue factor pathway inhibitor (TFPI), which not only regulate the initiation and amplification of the coagulation cascade but also inhibit the pro-inflammatory cytokines. Deficiency of AT III and APC (features of disseminated intravascular coagulation (DIC)) facilitates thrombin generation and promotes further endothelial cell dysfunction. Systemic inflammation During a severe inflammatory response, systemic release of cytokines and other mediators triggers widespread interaction between the coagulation pathways, platelets, endothelial cells and white blood cells, particularly the polymorphonuclear cells (PMNs). These ‘activated’ PMNs express adhesion factors (selectins), causing them initially to adhere to and roll along the endothelium, then to adhere firmly and migrate through the damaged and disrupted endothelium into the extravascular, interstitial space together with fluid and proteins, resulting in tissue oedema and inflammation. A vicious circle of endothelial injury, intravascular coagulation, microvascular occlusion, tissue damage and further release of inflammatory mediators ensues. All organs may become involved. This manifests in the lungs as the acute respiratory distress syndrome (ARDS) and in the kidneys as acute tubular necrosis (ATN), while widespread disruption of the coagulation system results in the clinical picture of DIC. The endothelium itself produces mediators that control blood vessel tone locally: endothelin 1, a potent vasoconstrictor, and prostacyclin and nitric oxide (NO, p. 82), which are systemic vasodilators. NO (which is also generated outside the endothelium) is implicated in both the myocardial depression and the profound vasodilatation of both arterioles and venules that causes the relative hypovolaemia and systemic hypotension found in septic/systemic inflammatory response syndrome (SIRS) shock. A major component of the tissue damage in septic/SIRS shock is the inability to take up and use oxygen at mitochondrial level, even if global oxygen delivery is supranormal. This effective bypassing of the tissues results in a reduced arteriovenous oxygen difference, a low oxygen extraction ratio, a raised plasma lactate and a paradoxically high mixed venous oxygen saturation (SvO2). Role of splanchnic ischaemia In shock, splanchnic hypoperfusion plays a major role in initiating and amplifying the inflammatory response, ultimately resulting in multiple organ failure (MOF). The processes involved include: • increased gut mucosal permeability • translocation of organisms from the gastrointestinal tract lumen into portal venous and lymphatic circulation • Kupffer cell activation with production and release of inflammatory mediators.

Couldn’t a pill help me?” Esther held up a hand defensively. “A happy pill?” “You mean an antidepressant?” He smiled wryly, setting his notepad down on the highly polished desk in front of the window. “Those doesn’t make people happy, only relieve the acute crisis for those suffering from depression.

There’s a Hasidic teaching, from Rebbe Nachman of Breslov: ‘There’s nothing as whole as a broken heart,’” Burger explained. “In these traditions, you cultivate a broken heart[,] which is very different from depression or sadness. It’s the kind of vulnerability, openness, and acute sensitivity to your own suffering and the suffering of others that becomes an opportunity for connection.

In times of depression and economic discontent—and by and large in times of acute national emergency—politics is more clearly a matter of interests, although of course status considerations are still present. In times of prosperity and general well-being on the material plane, status considerations among the masses can become much more influential in our politics.