“
Anatomically, physical pain is registered in one part of the brain, the thalamus, but its subjective impact is experienced in another part, the anterior cingulate cortex, or ACC. The brain gets the pain message in the thalamus, but “feels” it in the ACC. This latter area “lights up,” or is activated, when we are reacting to the pain stimulus. And it’s in the cortex—the ACC and elsewhere—that opiates help us endure pain by reducing not its physical but its emotional impact.
”
”