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The realization that there were electrical pathways connecting the brain to the body wasn’t systematically analyzed until the 1930s, when Dr. Wilder Penfield began working with epilepsy patients, who often suffered from debilitating convulsions and seizures that were potentially life-threatening. For them, the last option was to have brain surgery, which involved removing parts of the skull and exposing the brain. (Since the brain has no pain sensors, a person can be conscious during this entire procedure, so Dr. Penfield used only a local anesthetic during the operation.) Dr. Penfield noticed that when he stimulated certain parts of the cortex with an electrode, different parts of the body would respond. He suddenly realized that he could draw a rough one-to-one correspondence between specific regions of the cortex and the human body. His drawings were so accurate that they are still used today in almost unaltered form. They had an immediate impact on both the scientific community and the general public. In one diagram, you could see which region of the brain roughly controlled which function, and how important each function was. For example, because our hands and mouth are so vital for survival, a considerable amount of brain power is devoted to controlling them, while the sensors in our back hardly register at all. Furthermore, Penfield found that by stimulating parts of the temporal lobe, his patients suddenly relived long-forgotten memories in a crystal-clear fashion. He was shocked when a patient, in the middle of brain surgery, suddenly blurted out, “It was like … standing in the doorway at [my] high school.… I heard my mother talking on the phone, telling my aunt to come over that night.” Penfield realized that he was tapping into memories buried deep inside the brain. When he published his results in 1951, they created another transformation in our understanding of the brain.
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Michio Kaku (The Future of the Mind: The Scientific Quest to Understand, Enhance, and Empower the Mind)