Type 2 Diabetes Quotes

Coffee, even the decaffeinated version, appears to protect against type 2 diabetes. In a 2009 review, each additional daily cup of coffee lowered the risk of diabetes by 7 percent, even up to six cups per day.23

Because. Cupcakes make everything a little better. Except for type 2 diabetes, I guess.

The key to the proper treatment of type 2 diabetes is to get rid of the excess sugar, not just move it around the body. The problem is both too much glucose and too much insulin.

fasting is the simplest and surest method to force your body to burn sugar.

The root cause of the hyperglycemia in type 2 diabetes is high insulin resistance.

If the situation is getting worse, then the only logical explanation is that our understanding and treatment of type 2 diabetes is fundamentally flawed.

The simplest way to look at all these associations, between obesity, heart disease, type 2 diabetes, metabolic syndrome, cancer, and Alzheimer's (not to mention the other the conditions that also associate with obesity and diabetes, such as gout, asthma, and fatty liver disease), is that what makes us fat - the quality and quantity of carbohydrates we consume - also makes us sick.

Associated with this weight gain are increased risks in adulthood for joint problems, angina, high blood pressure, heart attacks, strokes, type 2 diabetes and, ultimately, premature death. Outside of the human costs, health experts estimate that treating adult obesity-related ailments will cost the American economy nearly $150 billion in 2009.

Metabolic syndrome, of which obesity and type 2 diabetes are a key part, are ultimately caused by—you guessed it—too much sugar.

If you don’t drink coffee, you should think about two to four cups a day. It can make you more alert, happier, and more productive. It might even make you live longer. Coffee can also make you more likely to exercise, and it contains beneficial antioxidants and other substances associated with decreased risk of stroke (especially in women), Parkinson’s disease, and dementia. Coffee is also associated with decreased risk of abnormal heart rhythms, type 2 diabetes, and certain cancers.12, 13 Any one of those benefits of coffee would be persuasive, but cumulatively they’re a no-brainer. An hour ago I considered doing some writing for this book, but I didn’t have the necessary energy or focus to sit down and start working. I did, however, have enough energy to fix myself a cup of coffee. A few sips into it, I was happier to be working than I would have been doing whatever lazy thing was my alternative. Coffee literally makes me enjoy work. No willpower needed. Coffee also allows you to manage your energy levels so you have the most when you need it. My experience is that coffee drinkers have higher highs and lower lows, energywise, than non–coffee drinkers, but that trade-off works. I can guarantee that my best thinking goes into my job, while saving my dull-brain hours for household chores and other simple tasks. The biggest downside of coffee is that once you get addicted to caffeine, you can get a “coffee headache” if you go too long without a cup. Luckily, coffee is one of the most abundant beverages on earth, so you rarely have to worry about being without it. Coffee costs money, takes time, gives you coffee breath, and makes you pee too often. It can also make you jittery and nervous if you have too much. But if success is your dream and operating at peak mental performance is something you want, coffee is a good bet. I highly recommend it. In fact, I recommend it so strongly that I literally feel sorry for anyone who hasn’t developed the habit.

Another, related issue is that longevity itself, and healthspan in particular, doesn’t really fit into the business model of our current healthcare system. There are few insurance reimbursement codes for most of the largely preventive interventions that I believe are necessary to extend lifespan and healthspan. Health insurance companies won’t pay a doctor very much to tell a patient to change the way he eats, or to monitor his blood glucose levels in order to help prevent him from developing type 2 diabetes. Yet insurance will pay for this same patient’s (very expensive) insulin after he has been diagnosed. Similarly, there’s no billing code for putting a patient on a comprehensive exercise program designed to maintain her muscle mass and sense of balance while building her resistance to injury. But if she falls and breaks her hip, then her surgery and physical therapy will be covered. Nearly all the money flows to treatment rather than prevention—and when I say “prevention,” I mean prevention of human suffering.

the odds are overwhelming that you will die as a result of one of the chronic diseases of aging that I call the Four Horsemen: heart disease, cancer, neurodegenerative disease, or type 2 diabetes and related metabolic dysfunction. To achieve longevity—to live longer and live better for longer—we must understand and confront these causes of slow death.

I believe that human beings are designed to be physically active and that not doing so creates energy imbalances within the body that ultimately contribute to obesity and other health problems. As evidence, over 500,000 people die each year from diseases linked to physical inactivity and obesity. Furthermore, rates of hypertension, hypercholesterolemia, type 2 diabetes, and certain forms of cancer have all tripled over the past 30 years corresponding to decreasing levels of daily physical activity and increasing rates of obesity.

failure of insulin to lower blood glucose is called insulin resistance. The

I should have titled it "Diet Like Your Life Depended On It!" because it's about so much more than just beating Diabetes.

1.Stop putting sugar in (low-carbohydrate diets, intermittent fasting). 2.Burn remaining sugar off (intermittent fasting).

All the conditions we thought were problems—obesity, insulin resistance, and beta cell dysfunction—are actually the body’s solutions to a single root cause—too much sugar.

Ironically, the ancestors of those who today are most at risk for type 2 diabetes were, during prehistory, not the sick and dying, but the survivors. If

Your waist size is such an important predictor of health because the type of fat that is stored around your waistline—called “visceral fat” or “belly fat”—is related to the release of proteins and hormones that cause inflammation, which can in turn damage your arteries and affect how you metabolize sugars and fats. For this reason, visceral fat is strongly linked to type 2 diabetes, heart disease, stroke, Alzheimer’s, and other chronic diseases. Seeing your waist size come down is a great indicator of improving health.

Scientists generally agree that the more HDL you have, the lower your risk for heart disease. As you might have imagined, people with Metabolic Syndrome and type 2 diabetes also typically have low levels of beneficial HDL. Exercise is one of the cheapest, easiest, and most effective ways to raise HDL. Consuming saturated fat is another!

overwhelming that you will die as a result of one of the chronic diseases of aging that I call the Four Horsemen: heart disease, cancer, neurodegenerative disease, or type 2 diabetes and related metabolic dysfunction. To achieve longevity—to live longer and live better for longer—we must understand and confront these causes of slow death.

Eat carbohydrates and blood sugar rises. Every first-year medical student knows this, every nurse or diabetes educator knows this, every person with diabetes who performs finger-stick blood sugars before and after meals knows this. Eat any food with more than just a few grams of carbohydrates and blood sugar will rise; the more carbohydrates you eat, the higher blood sugar will rise. Everyone also knows that foods like butter do not raise blood sugar, nor will a fatty cut of meat, olives, green bell peppers, broccoli, or chicken liver. And since the 1980s, when the sharp upward climb in type 2 diabetes (and obesity) began, the only component of diet that has increased is carbohydrates, not fat or proteins.4

To change our eating habits, we must learn to eat mindfully, being more aware of chewing and tasting what we eat so that the brain can register the incoming nutrients.

Living a healthy, joyful life is a gift you give yourself.

HOPE FOR THE FUTURE TYPE 2 DIABETES is currently the leading cause of blindness, kidney failure, amputations, heart attacks, strokes, and cancer. But it doesn’t have to be our future. The pages of The Obesity Code and The Diabetes Code contain the knowledge to reverse type 2 diabetes. This is not the end, but only the beginning. A new hope arises. A new dawn breaks.

Fatty liver is a completely reversible process. Emptying the liver of its surplus glucose and dropping insulin levels returns the liver to normal. Hyperinsulinemia drives DNL, which is the primary determinant of fatty liver disease. Normalizing insulin levels reverses the fatty liver. Refined carbohydrates, which cause large increases in insulin, are far more sinister than dietary fat. High carbohydrate intake can increase DNL tenfold, whereas high fat consumption, with correspondingly low carbohydrate intake, does not change hepatic fat production

type 2 diabetes doubles or triples your risk of developing Alzheimer’s disease, about the same as having one copy of the APOE e4 gene. On a purely mechanistic level, chronically elevated blood glucose, as seen in type 2 diabetes and prediabetes/insulin resistance, can directly damage the vasculature of the brain. But insulin resistance alone is enough to elevate one’s risk.

Type 2 diabetics drinking two tablespoons of apple cider vinegar diluted in water at bedtime reduced their fasting morning blood sugars.32 Higher doses of vinegar also seem to increase satiety, resulting in slightly lower caloric intake through the rest of the day (approximately 200 to 275 calories less). This effect was also noted for peanut products. Interestingly, peanuts also resulted in a reduction of glycemic response by 55 per cent.

When the American Dietetic Association (ADA) surveyed all the studies on food and health, they concluded not just that a vegetarian or vegan diet is as healthy as one that includes meat, but that “vegetarians have been reported to have lower body mass indices than non-vegetarians, as well as lower rates of death from ischemic heart disease, lower blood cholesterol levels, lower blood pressure, and lower rates of hypertension, type 2 diabetes, and prostate and colon cancer.

In 1979, researchers at the University of Kentucky studied 20 men with type 2 diabetes, all of whom had been taking an average of 26 units of insulin per day. The experimental diet included plenty of vegetables, fruits, whole grains, and beans, so it was high in fiber and carbohydrate. The diet was nearly vegetarian, with very little animal fat—in fact, very little fat of any kind. After just 16 days on the program, more than half of the men were able to stop taking insulin entirely, and their blood sugar levels were lower than before.4

When Franklin D. Roosevelt signed the Social Security Act in 1935, old age was defined as sixty-five years, yet estimated life expectancy in the United States at the time was sixty-one years for males and sixty-four years for females.62 A senior citizen today, however, can expect to live eighteen to twenty years longer. The downside is that he or she also should expect to die more slowly. The two most common causes of death in 1935 America were respiratory diseases (pneumonia and influenza) and infectious diarrhea, both of which kill rapidly. In contrast, the two most common causes of death in 2007 America were heart disease and cancer (each accounted for about 25 percent of total deaths). Some heart attack victims die within minutes or hours, but most elderly people with heart disease survive for years while coping with complications such as high blood pressure, congestive heart failure, general weakness, and peripheral vascular disease. Many cancer patients also remain alive for several years following their diagnosis because of chemo-therapy, radiation, surgery, and other treatments. In addition, many of the other leading causes of death today are chronic illnesses such as asthma, Alzheimer’s, type 2 diabetes, and kidney disease, and there has been an upsurge in the occurrence of nonfatal but chronic illnesses such as osteoarthritis, gout, dementia, and hearing loss.63 Altogether, the growing prevalence of chronic illness among middle-aged and elderly individuals is contributing to a health-care crisis because the children born during the post–World War II baby boom are now entering old age, and an unprecedented percentage of them are suffering from lingering, disabling, and costly diseases. The term epidemiologists coined for this phenomenon is the “extension of morbidity.

Yes, changing your lifestyle may seem impractical. It may seem impractical to give up meat and high-fat foods, but I wonder how practical it is to be 350 pounds and have Type 2 diabetes at the age of fifteen, like the girl mentioned at the start of this chapter. I wonder how practical it is to have a lifelong condition that can’t be cured by drugs or surgery; a condition that often leads to heart disease, stroke, blindness or amputation; a condition that might require you to inject insulin into your body every day for the rest of your life. Radically changing our diets may be “impractical,” but it might also be worth it.

Beyond being a promising anticancer agent,1 sulforaphane may also help protect your brain2 and your eyesight,3 reduce nasal allergy inflammation,4 manage type 2 diabetes,5 and was recently found to successfully help treat autism. A placebo-controlled, double-blind, randomized trial of boys with autism found that about two to three cruciferous vegetable servings’ worth6 of sulforaphane a day improves social interaction, abnormal behavior, and verbal communication within a matter of weeks. The researchers, primarily from Harvard University and Johns Hopkins University, suggest that the effect might be due to sulforaphane’s role as a “detoxicant.”7

I liken modern scientists to conquistadors. They have no idea what they're dealing with, but they're going to conquer it, whatever it is --- all in the name of God. Now, don't get me wrong, I'm not opposed to scientific discovery and exploration. I love this stuff. What I despise is reckless disregard for how little we know. We create trans fats with nary a question about whether they're good for us or not. We develop a food pyramid with carbohydrates on the bottom and thirty years later we realize it created an obesity and type 2 diabetes epidemic. It should give us all pause that we would be a much healthier nation if the government had never told us how to eat.

The fact is our bodies aren’t meant to ingest meat and dairy and eggs and fish. That’s right, our bodies aren’t meant to eat animals; they’re made for whole grains, vegetarian proteins like beans and legumes, fruits and vegetables, nuts and seeds. We may be omnivores in that our bodies are capable of living on just about anything—flesh included—in times of scarcity. But unless you are living in sub-Saharan Africa or some isolated part of the North Pole, scarcity is, fortunately, not a problem. In fact we are blessed with abundance. Our modern problem is obesity and all the degenerative diseases that are linked to obesity, like cancer, heart disease, and type 2 diabetes.

So why are we unable to acknowledge the truth? Dr. Fung’s answer is simple: we doctors lie to ourselves. If type 2 diabetes is a curable disease but all our patients are getting worse on the treatments we prescribe, then we must be bad doctors. And since we did not study for so long at such great cost to become bad doctors, this failure cannot be our fault. Instead, we must believe we are doing the best for our patients, who must unfortunately be suffering from a chronically progressive and incurable disease. It is not a deliberate lie, Dr. Fung concludes, but one of cognitive dissonance—the inability to accept a blatant truth because accepting it would be too emotionally devastating.

Experts on dietetics (the study of diet and its health effects) are finally recognising that balanced vegan diets are healthy. The British Dietary Association has stated well planned vegan diets can support healthy living in people of all ages, and other similar professional bodies all over the world agree. On the other side, the World Health Organization has classified processed meat as carcinogenic, and there is increasing evidence that eating lots of meat and dairy increases blood pressure and blood cholesterol, which leads to heart disease, and that cutting them out can significantly reduce your risk of type 2 diabetes, a disease which is affecting an increasing number of people in developed nations.

In a world of forty thousand choices, the old advice of 'everything in moderation' no longer cuts it. The signs are that many people have understandably had enough of this free-for-all of supersizing and hidden sugars, of type 2 diabetes and food waste. In the past five years, millions of eaters have rejected huge swaths of mainstream food and created their own rules to eat by. Such reactions offer a sliver of hope that eating -- for some populations anyway -- is finally moving in a healthier direction, with a new thoughtfulness about food and a return to vegetables. On the other hand, some of the new diet rules we have invented for ourselves are as extreme and unbalanced as the food system they seek to replace.

The less you sleep, the more you are likely to eat. In addition, your body becomes unable to manage those calories effectively, especially the concentrations of sugar in your blood. In these two ways, sleeping less than seven or eight hours a night will increase your probability of gaining weight, being overweight, or being obese, and significantly increases your likelihood of developing type 2 diabetes. The global health cost of diabetes is $375 billion a year. That of obesity is more than $2 trillion. Yet for the under-slept individual, the cost to health, quality of life, and a hastened arrival of death are more meaningful. Precisely how a lack of sleep sets you on a path toward diabetes and leads to obesity is now well understood and incontrovertible.

If we want to be healthy, we need to eat and move about a little more like our ancient ancestors did. That doesn’t mean we have to eat tubers and hunt wildebeest. It means we should consume a lot less processed and sugary foods and get more exercise. Failure to do that, however, is what is giving us the disorders like type 2 diabetes and cardiovascular disease that are killing us in great numbers. Indeed, as Lieberman notes, medical care is actually making things worse by treating the symptoms of mismatch diseases so effectively that we “unwittingly perpetuate their causes.” As Lieberman puts it with chilling bluntness, “You are most likely going to die from a mismatch disease.” Even more chillingly, he believes that 70 percent of the diseases that kill us could easily be preventable if we would just live more sensibly.

As devasting as it is, cirrhosis is not the only end point I’m worried about here. I care about NAFLD and NASH — and you should too — because they represent the tip of the iceberg of a global epidemic of metabolic disorders, ranging from insulin resistance to type 2 diabetes. Type 2 diabetes is technically a distinct disease, defined very clearly by glucose metrics, but I view it as simply the last stop on a railway line passing through several other stations, including hyperinsulinemia, prediabetes, and NAFLD/NASH. If you find yourself anywhere on this train line, even in the early stages of NAFLD, you are likely also en route to one or more of the three Horsemen diseases (cardiovascular disease, cancer, and Alzheimer’s disease). As we will see in the next few chapters, metabolic dysfunction vastly increases your risks for all of these.

You should maintain a moderate, not high, intake of protein. When it is digested, dietary protein, such as meat, breaks down into amino acids. Adequate protein is required for good health, but excess amino acids cannot be stored in the body and so the liver converts them into glucose. Therefore, eating too much protein adds sugar to the body. So you should avoid highly processed, concentrated protein sources such as protein shakes, protein bars, and protein powders.

Since 2005, researchers have been finding correlations between diabetes and risk for Alzheimer’s disease, especially when the diabetes is not controlled and a person suffers from chronic high blood sugar.7 Some have gone so far as to refer to Alzheimer’s disease as “type 3 diabetes,” because the disease often involves a disrupted relationship with insulin, the metabolic hormone involved in both types 1 and 2 diabetes. Insulin is the hormone needed to deliver sugar (glucose) into cells for use.

One of our greatest epidemics today is obesity. It is estimated that more than 500 million people suffer from obesity worldwide today, and that it kills more than three million people each year. In comparison, about 55,000 people are killed in war each year, which of course in no way suggests that we are overestimating the horror and seriousness of war – how could we? – but the little attention we give to obesity in comparison does suggest, however, that we are not taking the “war” we should be waging against obesity seriously. It seems that we overlook what a merciless killer and cause of pain that obesity and the overeating that leads to it really is: it increases the risk of heart disease (the most common cause of death worldwide), many kinds of cancer, type 2 diabetes, degenerative joint disease and mental problems such as depression and low self-esteem.[27] Fortunately, a lot seems to imply that we have a powerful and peaceful weapon at our hands that can help us overcome obesity: a vegan diet.

Human evolution is not over, but the chances of natural selection adapting our species in dramatic, major ways to common non-infectious mismatch diseases are remote unless conditions change dramatically. One reason is that many of these diseases have little to no effect on fertility. Type 2 diabetes, for example, generally develops after people have reproduced, and even then, it is highly manageable for many years.8 Another consideration is that natural selection can act only on variations that affect reproductive success and that are also genetically passed from parent to offspring. Some obesity-related illnesses can hinder reproductive function, but these problems have strong environmental causes.9 Finally, although culture sometimes spurs selection, it is also a powerful buffer. Every year new products and therapies are being developed that allow people with common mismatch diseases to cope better with their symptoms. Whatever selection is operating is probably occurring at a pace too slow to measure in our lifetimes.

Hunter-gatherers who survive childhood typically live to be old: their most common age of death is between sixty-eight and seventy-two, and most become grandparents or even great-grandparents.70 They most likely die from gastrointestinal or respiratory infections, diseases such as malaria or tuberculosis, or from violence and accidents.71 Health surveys also indicate that most of the noninfectious diseases that kill or disable older people in developed nations are rare or unknown among middle-aged and elderly hunter-gatherers.72 These admittedly limited studies have found that hunter-gatherers rarely if ever get type 2 diabetes, coronary heart disease, hypertension, osteoporosis, breast cancer, asthma, and liver disease. They also don’t appear to suffer much from gout, myopia, cavities, hearing loss, collapsed arches, and other common ailments. To be sure, hunter-gatherers don’t live in perpetually perfect health, especially since tobacco and alcohol have become increasingly available to them, but the evidence suggests that they are healthy compared to many older Americans today despite never having received any medical care. In short, if you were to compare contemporary health data from people around the world with equivalent data from hunter-gatherers, you would not conclude that rising rates of common mismatch diseases such as heart disease and type 2 diabetes are straightforward, inevitable by-products of economic progress and increased longevity. Moreover,

When should you be skeptical? Any time you see a report that a single food, beverage, supplement, food product, or ingredient causes or reduces the risk for obesity, heart disease, type 2 diabetes, or cancer, it is a good idea to envision a red warning flag flying high in the air. The studies may have identified associations between the food factor and the disease, but associations can be due to any number of other causes. Dietary patterns, not single factors, are what matter to health. Look out for words like “miracle” or “breakthrough.” Science tends to proceed in small increments and rarely works that way. And please be especially skeptical of “everything you thought you knew about nutrition is wrong.” Science does not work that way, either. Whenever you see “may” or “might”—as in “may reduce the risk of heart disease” or “might improve cognition in the elderly”—recognize that these also mean “may not” or “might not.” Overall, it is always a good idea to ask whether study results seem plausible in the light of everything else you know. As an eater, you should be wary of media hype about whether fat or sugar is a more important cause of health problems. This question ignores basic principles of nutrition: we eat foods, not nutrients, and how much we eat is often just as important as what we eat. Diets of enormous variety, from Asian diets traditionally based on rice (carbohydrates that convert to sugar in the body) to Mediterranean diets rich in olive oil (fat), can all promote long and healthy lives. The basic principles of eating healthfully have remained remarkably constant over the years: eat a wide variety of relatively unprocessed foods in reasonable amounts. Note that these same dietary principles apply to prevention of the entire range of diet-related chronic diseases. If an industry-funded study claims miraculous benefits from the sponsor’s products, think, “Advertising.

REPROGRAMMING MY BIOCHEMISTRY A common attitude is that taking substances other than food, such as supplements and medications, should be a last resort, something one takes only to address overt problems. Terry and I believe strongly that this is a bad strategy, particularly as one approaches middle age and beyond. Our philosophy is to embrace the unique opportunity we have at this time and place to expand our longevity and human potential. In keeping with this health philosophy, I am very active in reprogramming my biochemistry. Overall, I am quite satisfied with the dozens of blood levels I routinely test. My biochemical profile has steadily improved during the years that I have done this. For boosting antioxidant levels and for general health, I take a comprehensive vitamin-and-mineral combination, alpha lipoic acid, coenzyme Q10, grapeseed extract, resveratrol, bilberry extract, lycopene, silymarin (milk thistle), conjugated linoleic acid, lecithin, evening primrose oil (omega-6 essential fatty acids), n-acetyl-cysteine, ginger, garlic, l-carnitine, pyridoxal-5-phosphate, and echinacea. I also take Chinese herbs prescribed by Dr. Glenn Rothfeld. For reducing insulin resistance and overcoming my type 2 diabetes, I take chromium, metformin (a powerful anti-aging medication that decreases insulin resistance and which we recommend everyone over 50 consider taking), and gymnema sylvestra. To improve LDL and HDL cholesterol levels, I take policosanol, gugulipid, plant sterols, niacin, oat bran, grapefruit powder, psyllium, lecithin, and Lipitor. To improve blood vessel health, I take arginine, trimethylglycine, and choline. To decrease blood viscosity, I take a daily baby aspirin and lumbrokinase, a natural anti-fibrinolytic agent. Although my CRP (the screening test for inflammation in the body) is very low, I reduce inflammation by taking EPA/DHA (omega-3 essential fatty acids) and curcumin. I have dramatically reduced my homocysteine level by taking folic acid, B6, and trimethylglycine (TMG), and intrinsic factor to improve methylation. I have a B12 shot once a week and take a daily B12 sublingual. Several of my intravenous therapies improve my body’s detoxification: weekly EDTA (for chelating heavy metals, a major source of aging) and monthly DMPS (to chelate mercury). I also take n-acetyl-l-carnitine orally. I take weekly intravenous vitamins and alpha lipoic acid to boost antioxidants. I do a weekly glutathione IV to boost liver health. Perhaps the most important intravenous therapy I do is a weekly phosphatidylcholine (PtC) IV, which rejuvenates all of the body’s tissues by restoring youthful cell membranes. I also take PtC orally each day, and I supplement my hormone levels with DHEA and testosterone. I take I-3-C (indole-3-carbinol), chrysin, nettle, ginger, and herbs to reduce conversion of testosterone into estrogen. I take a saw palmetto complex for prostate health. For stress management, I take l-theonine (the calming substance in green tea), beta sitosterol, phosphatidylserine, and green tea supplements, in addition to drinking 8 to 10 cups of green tea itself. At bedtime, to aid with sleep, I take GABA (a gentle, calming neuro-transmitter) and sublingual melatonin. For brain health, I take acetyl-l-carnitine, vinpocetine, phosphatidylserine, ginkgo biloba, glycerylphosphorylcholine, nextrutine, and quercetin. For eye health, I take lutein and bilberry extract. For skin health, I use an antioxidant skin cream on my face, neck, and hands each day. For digestive health, I take betaine HCL, pepsin, gentian root, peppermint, acidophilus bifodobacter, fructooligosaccharides, fish proteins, l-glutamine, and n-acetyl-d-glucosamine. To inhibit the creation of advanced glycosylated end products (AGEs), a key aging process, I take n-acetyl-carnitine, carnosine, alpha lipoic acid, and quercetin. MAINTAINING A POSITIVE “HEALTH SLOPE” Most important,

Turn over a new leaf—of tea, that is. Not only is the virtually zero-calorie beverage filled with antioxidants that may help prevent cancer, but newer research shows that it may also improve your memory, mood, skin, alertness, problem solving, digestion, and heart and bone health. It may even prevent type 2 diabetes and help with weight management.

Imagine being able to tweak your gut microbial profile to help you effortlessly lose weight, terminate type 2 diabetes, reduce your risk for depression, dementia, and cancer, and support skin health. Similarly, imagine shifting the skin’s microbial characteristics to thwart acne outbreaks, block UV rays and prevent skin cancer, deflect mosquitoes (indeed, new research shows that the microbes on our skin affect whether or not we are bitten), and usher in that coveted healthy glow. That’s the promise that this exciting field of medicine has to offer. Time to get ready for it.

The study found that a ketogenic diet can lead to insulin resistance, fatty liver, a pro-inflammatory state, type 2 diabetes, heart disease, and unhealthy fat regulation, as well as elevated levels of cholesterol, triglycerides, and leptin.

It has been found that apple cider vinegar consumption increases insulin-stimulated glucose uptake tested via the forearm muscle in people with type 2 diabetes.

Further, researchers began compiling a list of diseases absent in indigenous populations, no matter where they lived on the planet, including and especially cardiovascular disease, high blood pressure, type 2 diabetes, arthritis, psoriasis, dental cavities, and acne. Note that this list includes some of the very diseases that constitute our worst problems today.

Type 2 diabetes is a lifestyle disease that results from eating sugar and refined carbohydrates. It appeared among the earliest recorded diseases of civilization, coincident with sugar and flour appearing in people’s diets in places as distinct as Africa and Arizona, and has been with us for more than a century. But this is not a static story.

Americans are consuming a diet that is at least half sugars in one form or another—calories providing virtually nothing but energy. The energy density of these refined carbohydrates contributes to obesity in two ways. First, we consume many more calories per unit of food; the fiber that’s been removed from these foods is precisely what would have made us feel full and stop eating. Also, the flash flood of glucose causes insulin levels to spike and then, once the cells have taken all that glucose out of circulation, drop precipitously, making us think we need to eat again. While the widespread acceleration of the Western diet has given us the instant gratification of sugar, in many people—especially those newly exposed to it—the speediness of this food overwhelms the ability of insulin to process it, leading to type 2 diabetes and all the other chronic diseases associated with metabolic syndrome.

Normally, when sugar enters the bloodstream from our gut, the pancreas secretes insulin into the bloodstream, and the insulin then travels to three main places: fat cells, muscle cells, and neurons. Insulin’s primary job is to open the door to any cell to allow glucose to enter and provide fuel, particularly to three important types of cells. 1. IN FAT CELLS, insulin attaches to a docking port on a fat cell membrane and flips a switch that tells the fat cell to convert that glucose to fat and store it. When insulin has done its job, it separates from the docking port and no more sugar can enter the cell. 2. IN MUSCLE CELLS, insulin unlocks the door to the cell and ushers in glucose to be used as fuel. 3. NERVE CELLS (neurons) also require insulin to admit glucose through their cell membrane. The fact that neurons require insulin to get glucose is a relatively new finding, and we now know that insulin resistance also occurs in the brain and nerves—it is called type 3 diabetes. Once insulin docks in the appropriate ports and releases information, the fat, muscle, or nerve cells tell the hormone that the message has been received. The hormone then backs out of the docking port, leaving it ready and available for the next hormone to attach.

A simple example from the field of medicine can help illustrate the Four Noble Truths. Let’s say you are diagnosed with type 2 diabetes (First Noble Truth), which was likely brought on by eating a poor diet and becoming very overweight (Second Noble Truth). Your doctor tells you the situation does not need to be like that and can be controlled (confirming the Third Noble Truth). You follow the doctor’s prescription—taking your medicine, eating better, and exercising more—which is your route to healing (Fourth Noble Truth).

Carbohydrates are as powerfully psychoactive as nicotine, alcohol and opioids, and are as rapidly addictive. Unless you are a performance athlete, most Type 2 diabetics are simply people who over time have transitioned away from eating for the nutritional value of food toward eating primarily for the endorphin release and emotional management effect of a powerful psychoactive drug called sugar.

Coffee If you don’t drink coffee, you should think about two to four cups a day. It can make you more alert, happier, and more productive. It might even make you live longer. Coffee can also make you more likely to exercise, and it contains beneficial antioxidants and other substances associated with decreased risk of stroke (especially in women), Parkinson’s disease, and dementia. Coffee is also associated with decreased risk of abnormal heart rhythms, type 2 diabetes, and certain cancers.12, 13 Any one of those benefits of coffee would be persuasive, but cumulatively they’re a no-brainer. An hour ago I considered doing some writing for this book, but I didn’t have the necessary energy or focus to sit down and start working. I did, however, have enough energy to fix myself a cup of coffee. A few sips into it, I was happier to be working than I would have been doing whatever lazy thing was my alternative. Coffee literally makes me enjoy work. No willpower needed. Coffee also allows you to manage your energy levels so you have the most when you need it. My experience is that coffee drinkers have higher highs and lower lows, energywise, than non–coffee drinkers, but that trade-off works. I can guarantee that my best thinking goes into my job, while saving my dull-brain hours for household chores and other simple tasks. The biggest downside of coffee is that once you get addicted to caffeine, you can get a “coffee headache” if you go too long without a cup. Luckily, coffee is one of the most abundant beverages on earth, so you rarely have to worry about being without it. Coffee costs money, takes time, gives you coffee breath, and makes you pee too often. It can also make you jittery and nervous if you have too much. But if success is your dream and operating at peak mental performance is something you want, coffee is a good bet. I highly recommend it. In fact, I recommend it so strongly that I literally feel sorry for anyone who hasn’t developed the habit. Pleasure

you view the current status of the human body as a whole, many countries, like the United States, now confront a novel paradox. On the one hand, more wealth and impressive advances in health care, sanitation, and education since the Industrial Revolution have dramatically improved billions of people’s health, especially in developed nations. Children born today are far less likely to die from infectious mismatch diseases caused by the Agricultural Revolution and they are much more likely to live longer, grow taller, and be generally healthier than children born in my grandfather’s generation. As a consequence, the world’s population tripled over the course of the twentieth century. But on the other hand, our bodies face new problems that were barely on anyone’s radar screen a few generations ago. People today are much more likely to get sick from new mismatch diseases such as type 2 diabetes, heart disease, osteoporosis, and colon cancer, which were either absent or much less common for most of human evolutionary history, including most of the agricultural era. To understand how and why all this happened—and how to address these new problems—requires considering the industrial era through the lens of evolution. How did the Industrial Revolution along with the growth of capitalism, medical science, and public health affect the way our bodies grow and function? In

One way to quantify the extension of morbidity currently occurring is a metric known as disability-adjusted life years (DALYs), which measures a disease’s overall burden as the number of years lost to ill health plus death.65 According to an impressive recent analysis of medical data worldwide from between 1990 and 2010, the burden of disability caused by communicable and nutrition-related diseases has plunged by more than 40 percent, while the burden of disability caused by noncommunicable diseases has risen, especially in developed nations. As examples, DALYs have risen by 30 percent for type 2 diabetes, by 17 percent for neurological disorders, such as Alzheimer’s, by 17 percent for chronic kidney disease, by 12 percent for musculoskeletal disorders, such as arthritis and back pain, by 5 percent for breast cancer, and by 12 percent for liver cancer.66 Even after factoring in population growth, more people are experiencing more chronic disability that results from noncommunicable diseases. For the diseases just mentioned, the number of years a person can expect to live with cancer has increased by 36 percent, with heart and circulatory diseases by 18 percent, with neurological diseases by 12 percent, with diabetes by 13 percent, and with musculoskeletal diseases by 11 percent.67 To many, old age is now equated with various disabilities (and

The main finding was that vegan and lacto-ovo vegetarian diets were associated with a nearly one-half reduction in risk of type 2 diabetes compared with the risk associated with nonvegetarian diets after adjustment for a number of socioeconomic and lifestyle factors, as well as low BMI, that are typically associated with vegetarianism. Pesco- and semi-vegetarian diets were associated with intermediate risk reductions: between one-third and one-quarter. These data indicate that vegetarian diets may in part counteract the environmental forces leading to obesity and increased rates of type 2 diabetes, though only vegan diets were associated with a BMI in the optimal range. Inclusion of meat, meat products, and fish in the diet, even on a less than weekly basis, seems to limit some of the protection associated with a vegan or lacto-ovo vegetarian diet. These findings may be explained by adverse effects of meat and fish, protective effects of typical constituents of vegan and lacto-ovo vegetarian diets, other characteristics of people who choose vegetarian diets, or a combination of these factors.

It is possible to prevent and recover completely from type 2 (adult-onset) diabetes. As

a 2014 meta-analysis (a compilation of many similar studies) showing that vegetarian diets may be particularly good at lowering blood pressure.110 And the more plants, perhaps, the better. Meat-free diets in general “confer protection against cardiovascular diseases . . . some cancers and total mortality,” but completely plant-based diets “seem to offer additional protection for obesity, hypertension, type-2 diabetes, and cardiovascular mortality.”111

The main finding was that vegan and lacto-ovo vegetarian diets were associated with a nearly one-half reduction in risk of type 2 diabetes compared with the risk associated with nonvegetarian diets after adjustment for a number of socioeconomic and lifestyle factors, as well as low BMI, that are typically associated with vegetarianism.

According to the American Heart Association, people with type 2 diabetes are two- to four-times more likely to have a stroke and two- to four-times more likely to die of heart disease. Type 2 diabetes can also lead to kidney damage or kidney failure, diseases of the eye and loss of vision, and nerve damage.

High, long-term intake of simple carbohydrates (disaccharides like sucrose and HFCS) has been associated with an increased risk of heart disease and type 2 diabetes.

With just 30 minutes of physical activity a day you can: Reduce health risks (high blood pressure, stroke, osteoporosis, coronary disease, type 2 diabetes, certain cancers) Keep off excess weight Ward of viral illnesses Help keep your arteries clear Strengthen your heart

He would sweet-talk her until she had Type 2 diabetes if he had to, but he couldn’t let her back out. More silence.

No it doesn’t. There are many complex genetic and environmental factors that can increase the risk of type 2 diabetes, but sugar is not a cause. It’s not uncommon to assume that because type 2 diabetes is characterised by having high blood sugar, consuming sugar must be the culprit. These two are not the same

posted my six-part lecture “The Aetiology of Obesity” series on YouTube1 and started my blog, “Intensive Dietary Management”2 to share my findings with the general public.

Cow’s milk consists of both casein and whey protein with approximately 80% of it consisting of casein. Although many people are lactose intolerant, it’s also common to be sensitive to casein. Other dairy products include casein, such as yogurt and cheese. There are different types of casein in dairy cows. The most common forms of beta-casein in dairy cattle breeds are A1 and A2. It is thought that beta-casein variant A1 yields the bioactive peptide beta-casomorphin-7 (BCM-7). This may play a role in the development of certain human diseases, such as diabetes mellitus and ischemic heart disease. There also might be a relationship of BCM-7 to sudden infant death syndrome.[14

If you have diabetes, reduce or remove dried fruit from your menu. In general, diabetics should have only one fruit serving with each meal. I strongly recommend that people with both type 1 and type 2 diabetes read my book The End of Diabetes.

-2 inhibitors The newest class of medication for type 2 diabetes is the SGLT-2 (sodium-glucose linked transporter) inhibitors. These drugs block the reabsorption of glucose by the kidney, so that it spills out in the urine. This lowers blood sugars, resulting in less insulin production. SGLT-2 inhibitors can lower glucose and insulin levels after a meal by as much as 35 per cent and 43 per cent respectively.21 But what effect do SGLT-2 inhibitors have on weight? Studies consistently show a sustained and significant weight loss in patients taking these drugs.22 Unlike virtually all dietary studies that show an initial weight loss followed by weight regain, this study found that the weight loss experienced by patients on SGLT-2 inhibitors continued for one year and longer.

EXCESSIVELY HIGH INSULIN resistance is the disease known as type 2 diabetes. High insulin resistance leads to elevated blood sugars, which are a symptom of this disease. In practical terms, this means that not only does insulin causes obesity, but also that insulin causes type 2 diabetes.

Sulfonylureas and metformin Several pills are available for the drug treatment of type 2 diabetes. The sulfonylurea class work by stimulating the pancreas to produce more insulin to lower blood sugars. All drugs in this class are well known to cause weight gain.

If you have been overweight or obese for a long time, if you suffer from PCOS (polycystic ovary syndrome), if you are prediabetic, or if you have type 2 diabetes. If this describes you, then it is likely that your body is severely insulin resistant (and if you have been diagnosed as prediabetic or with type 2 diabetes, then this is definitely going to be true for you). The key is going to be getting your insulin down over time so your body can heal. While fasting is wonderful for lowering insulin levels, you may also need a more structured dietary approach to lower insulin even more. Remember that we need to have lower levels of circulating insulin to tap into our fat stores for fuel during the fast. This is where a low-carb or keto plan can make a positive difference. You may not have to follow a lower-carb plan forever; a combination of low-carb eating and intermittent fasting can reverse your insulin resistance over time, and you may find that you can tolerate more carbs as time goes on and your body heals.

In Canada, an estimated one in three people lives with at least one chronic disease. Conditions that appeared to increase the risk and severity of COVID-19 included type 2 diabetes, obesity, high blood pressure and other heart conditions, chronic obstructive pulmonary disease (COPD), chronic kidney disease and cancer. All of these conditions have been shown to be associated with inadequate diets and malnutrition, either as a cause or consequence of the disease. We normally associate the word "malnutrition" with undernutrition or starvation. However, malnutrition also applies to overconsumption of calories, protein or fat and frequently results in overweight or obesity. A well-primed immune response depends on good nutrition to function, and malnutrition is known to increase susceptibility to infections. In turn, infection can aggravate malnutrition, since it increases the body's demand for nutrients. This creates a vicious cycle, further increasing vulnerability to infection. In Canada, malnutrition is much more widespread than we would like to believe. A cross-Canada study conducted in eighteen hospitals screened patients for malnutrition on admission and found 45 per cent of them to be malnourished. Those who were malnourished had significantly longer hospital stays than those who were not.

There are few insurance reimbursement codes for most of the largely preventive interventions that I believe are necessary to extend lifespan and healthspan. Health insurance companies won’t pay a doctor very much to tell a patient to change the way he eats, or to monitor his blood glucose levels in order to help prevent him from developing type 2 diabetes. Yet insurance will pay for this same patient’s (very expensive) insulin after he has been diagnosed.

spoke to Jason and immediately started fasting and applying his principles of good nutrition, eating a variety of low-carb, healthy-fat, whole foods. Within weeks, I realized that, for my whole life, just about everything I’d learned about nutrition was wrong. It’s been eight years since I began following Dr. Fung’s recommendations, and I’ve maintained an eighty-six-pound weight loss. I have completely reversed my type 2 diabetes, fatty liver, and PCOS.

Excessive insulin causes obesity, and excessive insulin causes insulin resistance, which is the disease known as type 2 diabetes.

Type 2 diabetes, like obesity, is a disease of too much insulin. The treatment is to lower insulin, not raise it. We were making things worse. We were fighting the fire with gasoline.

the Horsemen: cardiovascular and cerebrovascular disease, cancer, Alzheimer’s disease and related neurodegenerative conditions, and type 2 diabetes and related metabolic dysfunction.

Another, related issue is that longevity itself, and healthspan in particular, doesn’t really fit into the business model of our current healthcare system. There are few insurance reimbursement codes for most of the largely preventive interventions that I believe are necessary to extend lifespan and healthspan. Health insurance companies won’t pay a doctor very much to tell a patient to change the way he eats, or to monitor his blood glucose levels in order to help prevent him from developing type 2 diabetes. Yet insurance will pay for this same patient’s (very expensive) insulin after he has been diagnosed.

Therefore, eating too much protein adds sugar to the body. So you should avoid highly processed, concentrated protein sources such as protein shakes, protein bars, and protein powders.

Having type 2 diabetes raises a person’s risk of dying, in some cases to a small degree, in other cases substantially, but it is treatable using drugs, diet, and exercise. Although drugs help, they aren’t always necessary. Diet and exercise can sometimes allow the body to heal itself. In one dramatic test of this concept, ten overweight Australian aborigines with type 2 diabetes reversed their disease after just seven weeks of returning to an active hunting and gathering lifestyle.20 The mechanisms by which physical activity helps prevent and treat type 2 diabetes are well studied. Most basically, exercise (in conjunction with diet) can ameliorate every characteristic of metabolic syndrome including excess organ fat, high blood pressure, and high levels of blood sugar, fat, and cholesterol. In addition, exercise lowers inflammation and counteracts many of the damaging effects of stress. And most remarkably, exercise can reverse insulin resistance by restoring blocked insulin receptors and causing muscle cells to produce more of the transporter molecules that shuttle sugar out of the bloodstream.21 The effect is akin to unclogging a drain and flushing out the pipes. Altogether, by simultaneously improving the delivery, transport, and use of blood sugar, exercise can resuscitate a once resistant muscle cell to suck up as much as fiftyfold more molecules of blood sugar. No drug is so potent.

In one compelling study, Danish researchers randomized patients with type 2 diabetes into two groups: both were given advice on how to eat a healthy diet, but one group also labored through five or six 30- to 60-minute-long sessions of aerobic exercise a week plus two or three weight sessions per week. After a year, half of those who exercised were able to eliminate their diabetes medications, and another 20 percent were able to reduce their medication levels. Further, the more they exercised, the more they recovered normal function. In contrast, just one-quarter of the dieters were able to reduce their medication, and 40 percent had to increase their medication levels despite receiving excellent, standard health care.24 As we have repeatedly seen, some exercise is better than none, and more is better.

vitamin or mineral yet identified that is not available from low-carbohydrate sources—and many grain foods only appear to have a good nutritional profile because they’ve been enriched at the factory. Enrichment was instituted when it became clear that people whose diets depended on milled grains were developing nutritional deficiency diseases. It is likely that your nutritional profile will improve. That said, we do recommend taking a well-formulated, iron-free multivitamin daily. WHAT ABOUT “GOOD CARBS”? No doubt you’ve heard that there are “good carbs.” It may come as a shock, then, to learn that once they are digested and absorbed there is chemically no difference between one source of sugar and another. A molecule of glucose derived from brown rice is identical to a molecule of glucose derived from a convenience store slushy. The brown rice brings a few vitamins along with

SUGAR Because of the term “blood sugar,” many believe that sugar is the enemy. It is, but not the only one. All carbohydrates are composed of sugar. Starches—potatoes, bread, cereal, and the like—are simply a lot of sugar molecules strung together. Digestion quickly converts them to glucose. Starches raise your blood sugar as much as any sugar. Doubt it? The journal Diabetes Care states that whole-wheat bread will raise your blood sugar more rapidly than an equivalent quantity of table sugar. Yikes.

common for diet plans to make allowances for “cheating.” And the ads on television give testament to all the ways people try to fool themselves into thinking that there is some “healthy” way to continue their addiction, from sugar-loaded “fiber bars” to sugar-loaded “fruit” punch with a few added vitamins. You cannot afford this. Every time your blood sugar goes above 120 mg/dL (6.7 mmol/L) your body sustains irreversible damage, and that damage adds up. Every time you fall for this nonsense, you will move a little closer to disastrous consequences.

to exercise, great. But we’re not going to push you. Until you shift over to a fat- and ketone-burning metabolism and get access to the tank, you’re likely to be tired. You should feel your energy level rise as your body adjusts. If you find yourself wanting to go for a walk, go dancing, take a yoga class, or lift weights—we’re all for it. But don’t make yourself miserable.

what we now call type 2 diabetes is not a disease of insulin deficiency (as type 1 is)—at least not at first—but of insulin resistance.

Studies have shown that just one night of sleep deprivation can make you as insulin resistant as a person with type 2 diabetes. This translates directly to aging faster, decreased libido, and storing more body fat than you want to (say it ain’t so!).

In adult-onset diabetes (type 2, non-insulin-dependent diabetes), the trouble is not too little insulin, but the failure of the cells to respond to insulin. Another name for the disorder is thus insulin-resistant diabetes.

Ultra-processed foods make up 60 percent of calories consumed by adults and 67 percent of calories consumed by children, and they drive Bad Energy diseases like obesity, high blood pressure, dementia, type 2 diabetes, and insulin resistance.

The good news: Type 2 diabetes is almost always preventable, often treatable, and sometimes even reversible through diet and lifestyle changes.

Professor Taylor’s research suggests that it is the buildup of fat inside the liver and pancreas that causes all the trouble. These two organs are responsible for controlling our insulin and blood sugar levels. As they get clogged up with fat they stop communicating with each other. Eventually your body stops producing insulin and you become a type 2 diabetic.

Essential hypertension, i.e. high blood pressure without known cause, is hyperinsulin, type 2 diabetes until proven otherwise by oral glucose tolerance with insulin assays.

Knowledge (remember) You know enough to be able to recite knowledge by rote (e.g. you can recite the 15 causes of clubbing) Comprehension (understand) You understand the knowledge, so can explain it to others (e.g. you can explain what clubbing is) Application (apply) You can use the knowledge you have to solve problems (you use your knowledge of clubbing to try and work out why the patient in front of you has clubbed fingers) Analysis (analyse) You can use the knowledge you have to compare and contrast with other knowledge and see how it fits in with other people's assumptions and/or hypotheses (e.g. compare and contrast type 1 and type 2 diabetes; compare and contrast the electron as a particle and the electron as an electromagnetic wave) Synthesis (create) You can use knowledge, integrated with other knowledge, to produce new hypotheses (e.g. you know glucose crosses the placenta and that insulin does not; you know that in diabetes glucose tends to run high, so you hypothesise that the baby of a woman with diabetes will produce high levels of insulin itself and so will be at risk of going ‘hypo’ after birth) Evaluation (evaluate) You use your knowledge to assess, critique or judge others

Without proper sleep, you are doing yourself a disservice. For instance, lack of sleep has not only been linked to poor performance and alertness 11, but also to weight gain, Type 2 Diabetes, and memory problems 12.