Transplant Related Quotes

He knew what his father thought: that immigration, so often presented as a heroic act, could just as easily be the opposite; that it was cowardice that led many to America; fear marked the journey, not bravery; a cockroachy desire to scuttle to where you never saw poverty, not really, never had to suffer a tug to your conscience; where you never heard the demands of servants, beggars, bankrupt relatives, and where your generosity would never be openly claimed; where by merely looking after your wife-child-dog-yard you could feel virtuous. Experience the relief of being an unknown transplant to the locals and hide the perspective granted by journey. Ohio was the first place he loved, for there at last he had been able to acquire poise --

A third layer of nativeness was composed of those whom others thought directly descended, even the tiniest fraction of their genes, from the human beings who had been brought from Africa centuries ago as slaves. While this layer of nativeness was not vast in proportion of the rest, it had vast importance, for society had been shaped in reaction to it. An unspeakable violence had occurred in relation to it, and yet it endured, fertile, a stratum of soil that perhaps made possible all future transplanted soils.

The sick suffer alone, they undergo procedures and surgeries alone, and in the end, they die alone. Transplant is different. Transplant is all about having someone else join you in your illness. It may be in the form of an organ from a recently deceased donor, a selfless gift given by someone has never met you, or a kidney or liver from a relative, friend or acquaintance. In every case, someone is saying, in effect, “Let me join you in the recovery, your suffering, your fear of the unknown, your desire to become healthy, to get your life back. Let me bear some of your risk with you.

If people are relocated or, rather, transplanted from a steep, mountainous place to a plain, they also realize, but too late, that their home-place has been part of themselves - that they have identified with features of the place. And the way of life in the tiny locality, the density of social relations, has formed their persons. Again, they are not the same as they were.

You’re just living a normal life — never been sick, never been unhealthy, and all of a sudden you are fighting for your life. And this is happening to individuals every day,” Thomas said. The infection went to her blood stream and bone marrow and caused septic shock and organ failure. After undergoing multiple surgeries including a bone-marrow transplant and a “never-ending cycle of antibiotics,” she survived the ordeal.1​➔​ Thomas survived relatively intact. Some don’t, losing limbs in a desperate bid to stop the infection from spreading and then living permanently debilitated lives. Others aren’t even that “lucky.” Denis

was my first indication that the policies of Mamaw’s “party of the working man”—the Democrats—weren’t all they were cracked up to be. Political scientists have spent millions of words trying to explain how Appalachia and the South went from staunchly Democratic to staunchly Republican in less than a generation. Some blame race relations and the Democratic Party’s embrace of the civil rights movement. Others cite religious faith and the hold that social conservatism has on evangelicals in that region. A big part of the explanation lies in the fact that many in the white working class saw precisely what I did, working at Dillman’s. As far back as the 1970s, the white working class began to turn to Richard Nixon because of a perception that, as one man put it, government was “payin’ people who are on welfare today doin’ nothin’! They’re laughin’ at our society! And we’re all hardworkin’ people and we’re gettin’ laughed at for workin’ every day!”20 At around that time, our neighbor—one of Mamaw and Papaw’s oldest friends—registered the house next to ours for Section 8. Section 8 is a government program that offers low-income residents a voucher to rent housing. Mamaw’s friend had little luck renting his property, but when he qualified his house for the Section 8 voucher, he virtually assured that would change. Mamaw saw it as a betrayal, ensuring that “bad” people would move into the neighborhood and drive down property values. Despite our efforts to draw bright lines between the working and nonworking poor, Mamaw and I recognized that we shared a lot in common with those whom we thought gave our people a bad name. Those Section 8 recipients looked a lot like us. The matriarch of the first family to move in next door was born in Kentucky but moved north at a young age as her parents sought a better life. She’d gotten involved with a couple of men, each of whom had left her with a child but no support. She was nice, and so were her kids. But the drugs and the late-night fighting revealed troubles that too many hillbilly transplants knew too well. Confronted with such a realization of her own family’s struggle, Mamaw grew frustrated and angry. From that anger sprang Bonnie Vance the social policy expert: “She’s a lazy whore, but she wouldn’t be if she was forced to get a job”; “I hate those fuckers for giving these people the money to move into our neighborhood.” She’d rant against the people we’d see in the grocery store: “I can’t understand why people who’ve worked all their lives scrape by while these deadbeats buy liquor and cell phone coverage with our tax money.

The attachment voids experienced by immigrant children are profound. The hardworking parents are focused on supporting their families economically and, unfamiliar with the language and customs of their new society, they are not able to orient their children with authority or confidence. Peers are often the only people available for such children to latch on to. Thrust into a peer-oriented culture, immigrant families may quickly disintegrate. The gulf between child and parent can widen to the point that becomes unbridgeable. Parents of these children lose their dignity, their power, and their lead. Peers ultimately replace parents and gangs increasingly replace families. Again, immigration or the necessary relocation of people displaced by war or economic misery is not the problem. Transplanted to peer-driven North American society, traditional cultures succumb. We fail our immigrants because of our own societal failure to preserve the child-parent relationship. In some parts of the country one still sees families, often from Asia, join together in multigenerational groups for outings. Parents, grandparents, and even frail great-grandparents mingle, laugh, and socialize with their children and their children's offspring. Sadly, one sees this only among relatively recent immigrants. As youth become incorporated into North American society, their connections with their elders fade. They distance themselves from their families. Their icons become the artificially created and hypersexualized figures mass-marketed by Hollywood and the U.S. music industry. They rapidly become alienated from the cultures that have sustained their ancestors for generation after generation. As we observe the rapid dissolution of immigrant families under the influence of the peer-oriented society, we witness, as if on fast-forward video, the cultural meltdown we ourselves have suffered in the past half century. It would be encouraging to believe that other parts of the world will successfully resist the trend toward peer orientation. The opposite is likely to be the case as the global economy exerts its corrosive influences on traditional cultures on other continents. Problems of teenage alienation are now widely encountered in countries that have most closely followed upon the American model — Britain, Australia, and Japan. We may predict similar patterns elsewhere to result from economic changes and massive population shifts. For example, stress-related disorders are proliferating among Russian children. According to a report in the New York Times, since the collapse of the Soviet Union a little over a decade ago, nearly a third of Russia's estimated 143 million people — about 45 million — have changed residences. Peer orientation threatens to become one of the least welcome of all American cultural exports.

Why are we as helpless, or more so, than our ancestors were in facing the chaos that interferes with happiness? There are at least two good explanations for this failure. In the first place, the kind of knowledge—or wisdom—one needs for emancipating consciousness is not cumulative. It cannot be condensed into a formula; it cannot be memorized and then routinely applied. Like other complex forms of expertise, such as a mature political judgment or a refined aesthetic sense, it must be earned through trial-and-error experience by each individual, generation after generation. Control over consciousness is not simply a cognitive skill. At least as much as intelligence, it requires the commitment of emotions and will. It is not enough to know how to do it; one must do it, consistently, in the same way as athletes or musicians who must keep practicing what they know in theory. And this is never easy. Progress is relatively fast in fields that apply knowledge to the material world, such as physics or genetics. But it is painfully slow when knowledge is to be applied to modify our own habits and desires. Second, the knowledge of how to control consciousness must be reformulated every time the cultural context changes. The wisdom of the mystics, of the Sufi, of the great yogis, or of the Zen masters might have been excellent in their own time—and might still be the best, if we lived in those times and in those cultures. But when transplanted to contemporary California those systems lose quite a bit of their original power. They contain elements that are specific to their original contexts, and when these accidental components are not distinguished from what is essential, the path to freedom gets overgrown by brambles of meaningless mumbo jumbo. Ritual form wins over substance, and

Already embittered at being separated from loved ones, slaves on the frontier grew 'mean.' Planters, eager to get on with the work at hand, often countered the slaves' discontent by pressing them with greater force, only to find that slaves called their bet and then raised the stakes, resisting with still greater force. As the struggle escalated, planters discovered that even their best hands became unmanageable. One planter noted that his previously compliant slaves evinced 'a general disregard (with a few exceptions) of orders . . . and an unwillingness to be pressed hard at work.' In the face of festering anger, planters struggled to sustain the old order. Drawing on lessons of mastership that had been nearly two hundred years in the making on the North American mainland, planters instituted a familiar regime: they employed force freely and often; created invidious divisions among the slaves; and exacted exemplary punishments for the smallest infraction. If they sometimes extended the carrot of privilege, the stick was never far behind. The results were violent and bloody, as slave masters made it clear that slaves, by definition, had no rights they need respect. The plantation did not just happen; it had to be made to happen. Planter authority did not transplant easily. Relations between masters and slaves teetered toward anarchy on the cotton frontier. In some places, negotiations between owners and owned became little more than hard words and angry threats. Rumors of rebellion seemed to be everywhere. 'Scarcely a day passes,' observed Mississippi's territorial governor in 1812, 'without my receiving some information relative to the designs of those people to insurrect.' While few rebelled, some joined gangs of bandits and outlaws who resided in the middle ground between the westward-moving planters and the retreating Indians. On the plantations, slave masters saw sabotage everywhere - in broken tools, maimed animals, and burned barns. Slaves regularly took flight to the woods, and a few, eager to regain the world they had lost, tried to retrace their steps to Virginia or the Carolinas. It was a doubtful enterprise, and success was rare. Recaptured, they faced an even grimmer reality than before.

This chicken-and-egg problem is common in scientific research and is often difficult to address. Often we can say with certainty only that two factors (the microbiota and obesity, in this case) are correlated or coincident, but not necessarily causally related. However, here is where the power of the gnotobotic mouse can really be seen. Jeff’s team transplanted the microbiota from the obese mice into lean mice with no previous microbiota. Suddenly the lean mice with the obese microbiota began to gain weight, even though there had been no change in their diet or exercise habits! What these scientists had shown, to the surprise of many, was that the gut microbiota is enough to cause weight gain in an otherwise lean, healthy mouse. These findings forced the scientific community to reframe our view of the gut microbes. Clearly the microbiota is not just a collection of innocuous bacteria loitering within our gut. These bacteria are capable of profoundly changing the biology of their host and may be a major contributor to one of the most alarming health issues in the Western world.

The liquid modern variety of adiaphorization is cut after the pattern of the consumer–commodity relation, and its effectiveness relies on the transplantation of that pattern to interhuman relations.

In any case, the theory of Brownian motion was independently developed in 1900 by a Frenchman, Louis Bachelier. Bachelier was not actually concerned with the motion of microscopic particles suspended in a liquid. He was concerned with prices on the French stock market. Prices on the Bourse, like particles in a liquid, are subject to a vast array of random forces, so many that the prices’ behavior can only be studied probabilistically. This is exactly what Bachelier did in his remarkable doctoral thesis, “The Theory of Speculation.” Yet although his paper is couched in terms of futures and stock options and “call-o-more’s” (whatever those are), the mathematics is identical to that of Brownian motion, and Bachelier’s equation explaining the drift of prices with time is the same as the one Einstein later derived for the position of particles. In his paper Bachelier anticipated the Black-Scholes approach to options trading, and for his prescient work he has in recent years been crowned the “father of economic modeling.” At the time, though, Bachelier seems to have been ignored, and he passed into obscurity. Could Einstein have known of his predecessor’s work and merely transplanted the mathematics to particles? I am aware of no evidence that this is the case.

There is, however, another possibility, namely, the ritual around the Great Idaean Mother of Gods differed at first from that of Cybele, whose cult featured eunuch-attendants. In Greece, the transplanted mother goddess lost her various Phrygian names related to locations and mountains. Even her name, Cybele, was substituted by the title Great Mother (Mētēr Megalē). This reflected the Hellenization of Cybele, whose cult was thoroughly “de-orientalized.”67 Despite this, the galli of Cybele did not disappear. Cultic rituals scarcely changed, since a change meant a tampering with what had proved to be effective and thus invited a breach in the mankind-deities alignment.

Giving the drug daily, as is typically done with transplant patients, appears to inhibit both complexes, while dosing the drug briefly or cyclically inhibits mainly mTORC1, unlocking its longevity-related benefits, with fewer unwanted side effects. (A rapamycin analog or “rapalog” that selectively inhibited mTORC1 but not mTORC2 would thus be more ideal for longevity purposes, but no one has successfully developed one yet.) As it is, its known side effects remain an obstacle to any clinical trial of rapamycin for geroprotection (delaying aging) in healthy people.

This is why I love the field of transplant. Since I began taking care of sick people, I have noticed that one of the hardest things about getting sick, really sick, is that you are separated from the people you love. Even when families are dedicated to the patient, illness separates the well from the sick. The sick suffer alone, they undergo procedures and surgeries alone, and in the end, they die alone. Transplant is different. Transplant is all about having someone else join you in your illness. It may be in the form of an organ from a recently deceased donor, a selfless gift given by someone who has never met you, or a kidney or liver from a relative, friend, or acquaintance. In every case, someone is saying, in effect, “Let me join you in your recovery, your suffering, your fear of the unknown, your desire to become healthy, to get your life back. Let me bear some of your risk with you.

Plasticity of neuroendocrine-thymus interactions during aging N.Fabris12E.Mocchegiani2M.Provinciali2 Abstract Thymic regrowth and reactivation of thymic endocrine activity may be achieved even in old animals by different endocrinological or nutritional manipulations such as, (a) intrathymic transplantation of pineal gland or treatment with melatonin, (b) implantation of a growth hormone (GH) secreting tumor cell line or treatment with exogenous GH, (c) castration or treatment with exogenous luteinizing hormone-releasing hormone (LH-RH), (d) treatment with exogenous thyroxine or triiodothyronine, and (e) nutritional interventions such as arginine or zinc supplementation. These data strongly suggest that thymic involution is a phenomenon secondary to age-related alterations in neuroendocrine-thymus interactions and that it is the disruption of such interactions in old age that is responsible for age-associated dysfunction. Melatonin or other pineal factors may act through specific receptors, but experimental evidence is still lacking. The role of zinc, whose turnover is usually reduced in old age, is diverse. The effects range from the reactivation of zinc-dependent enzymes, required for both cell proliferation and apoptosis, to the reactivation of thymulin, a zinc-dependent thymic hormone. The role of zinc may even be more crucial. According to recent preliminary data obtained both in animal and human studies, it appears that the above reported endocrinological manipulations capable of restoring thymic activity in old age, may act also by normalizing the altered zinc pool.

If a thing is to have a market value, it must be detachable or alienable so that it can be put on the scale and compared. I mean this in a particular sense: we who do the valuation must be able to stand apart from the thing we are pricing. We have to be able to conceive of separating ourselves from it. I may be fond of my wristwatch but I can put a value on it because I can imagine parting with it. But my heart has no market value (at least not to me!), for to detach it is inconceivable. (I address below the interesting question of value in relation to body organs used for transplant.) We feel it inappropriate, even rude, to be asked to evaluate in certain situations.

third layer of nativeness was composed of those who others thought directly descended, even in the tiniest fraction of their genes, from the human beings who had been brought from Africa to this continent centuries ago as slaves. While this layer of nativeness was not vast in proportion to the rest, it had vast importance, for society had been shaped in reaction to it, and unspeakable violence had occurred in relation to it, and yet it endured, fertile, a stratum of soil that perhaps made possible all future transplanted soils, and to which Saeed in particular was attracted, since at a place of worship where he had gone one Friday the communal prayer was led by a man who came from this tradition and spoke of this tradition, and Saeed had found, in the weeks he and Nadia had been in Marin, this man’s words to be full of soul-soothing wisdom.

The study of stem cell niches in mammalian systems presents an 'arduous endeavor'; in comparison, the fly germarium is relatively easy to manipulate. In the 1990s, H. Lin, A.C. Spradling, and others used of a number of approaches to study Drosophilia GSCs and their niche, including killing specific cells in the germarium with precisely directed lasers; transplantation of cells from the ovary of one fly to another; and genetic perturbations that included the dialing up or down of Hh pathway signaling. The researchers found that following laser ablation of cells surrounding the GSCs - that is killing the niche cells - all the GSCs went on to form eggs, and the system was quickly depleted of its GSC reserve. Moreover, through genetic analyses the researchers identified specific genes required in the niche cells to maintain GSCs within the niche, as would be deduced for a gene that, when disrupted in niche cells, has the same effect as laser ablation of those cells. These studies are credited with providing the first clear experimental evidence of a stem cell niche, as well as defining what genes - what signaling pathways and other cellular activities - are important to the process. Many of the same pathways relevant in other cell types proved relevant to communication between the niche and GSCs, including the Hh pathway. The genes required for suppression of transposon mobilization by the piRNA system also have relevance to the GSC niche; disruption of the piwi gene, for example, can lead to uncontrolled proliferation of GSCs.

Please forgive me for inconveniencing you, Mr. Winterborne. I don’t intend to stay long.” “Does anyone know you’re here?” he asked curtly. “No.” “Speak your piece, then, and make it fast.” “Very well. I--” “But if it has anything to do with Lady Helen,” he interrupted, “then leave now. She can come to me herself if there’s something that needs to be discussed.” “I’m afraid Helen can’t go anywhere at the moment. She’s been in bed all day, ill with a nervous condition.” His eyes changed, some unfathomable emotion spangling the dark depths. “A nervous condition,” he repeated, his voice iced with scorn. “That seems a common complaint among aristocratic ladies. Someday I’d like to know what makes you all so nervous.” Kathleen would have expected a show of sympathy or a few words of concern for the woman he was betrothed to. “I’m afraid you are the cause of Helen’s distress,” she said bluntly. “Your visit yesterday put her in a state.” Winterborne was silent, his eyes black and piercing. “She told me only a little about what happened,” Kathleen continued. “But it’s clear that there is much you don’t understand about Helen. My late husband’s parents kept all three of their daughters very secluded. More than was good for them. As a result, all three are quite young for their age. Helen is one-and-twenty, but she hasn’t had the same experiences, or seasoning, as other girls her age. She knows nothing of the world outside Eversby Priory. Everything is new to her. Everything. The only men she has ever associated with have been a handful of close relations, the servants, and the occasional visitor to the estate. Most of what she knows about men has been from books and fairy tales.” “No one can be that sheltered,” Winterborne said flatly. “Not in your world. But at an estate like Eversby Priory, it’s entirely possible.” Kathleen paused. “In my opinion, it’s too soon for Helen to marry anyone, but when she does…she will need a husband with a placid temperament. One who will allow her to develop at her own pace.” “And you assume I wouldn’t,” he said rather than asked. “I think you will command and govern a wife just as you do everything else. I don’t believe you would ever harm her physically, but you’ll whittle her to fit your life, and make her exceedingly unhappy. This environment--London, the crowds, the department store--is so ill suited to her nature that she would wither like a transplanted orchid. I’m afraid I can’t support the idea of marriage for you and Helen.” Pausing, she took a long breath before saying, “I believe it’s in her best interest for the engagement to be broken.

Post-transplant OT was awful. I knew it would be even before it started. Just thinking about it made me seethe. “Just let some perky little shit come in here and try to explain how I should put my socks on.” I don’t think she even completed the evaluation, poor Whoever She Was. I never forgot how to dress myself or perform a single iota of function relating to my activities of daily living.