Tissue Identity Quotes

We are each a product of our biological endowments, culture, and personal history. Culture ideology and cultural events along with transmitted cultural practices influences each of us. We are each the product of our collective interchanges. Our county’s domestic and interlinked international conflicts fuse us together. We are each a molecule in the helix of human consciousness joined in a physical world. We form a coil of connective tissue soldered together by cultural links.

Writers use both their blood and their brains to explore the darkest recesses of their pooling self. Writing allows us to harness the whimsy of the collaborative mind and body, pull our tissue apart like taffy, and expose the composition of our life sustaining organs. Telling our personal story forces us to account for any actions that made us laugh, cry, scream and shout, or hide behind a cloak of mootness. Critical examination of the self allows one to disintegrate the envelope of their present personality and make up a new imaging.

Focusing on individual nutrients, their identities, their contents in food, their tissue concentrations, and their biological mechanisms, is like using math and physics to catch balls. It’s not the way nature evolved, and it makes proper nutrition far more difficult than it needs to be. Our bodies use countless mechanisms, strategically placed throughout our digestion, absorption, and transport and metabolic pathways, to effortlessly ensure tissue concentrations consistent with good health—no database consultation required. But as long as we let reductionism guide our research and our understanding of nutrition, good health will remain unattainable.

Until such time as duplications of individual nervous systems can be grown in tissue cultures (at this point no one knows "whose" consciousness they would have), our special identities will always be subject to being hit by a truck or dying in a plane crash. A sudden virus or heart seizure, even in the body's youth, may carry us off. Statistically, looking ahead thousands of years, the chances are that every human and even inanimate form will be broken sooner or later. But the distress felt by men and women today does not arise from the fear of such hazards. Rather, it comes from the certainty of aging and physical degeneration leading to death. It is the fear of losing our powers and being left alone, or in the hands of indifferent nurses, and knowing that the moment must come when we will not see the people we love any more, and everything will go black.

Consider your arms and legs. They contain exactly the same kinds of muscle cells, nerve cells, and so on. They contain the same proteins and other chemicals; the bones are made of identical substance. Yet they have different shapes, just as houses of different design can be made from the same building materials. The chemicals alone do not determine the form. Nor does the DNA. The DNA is the same in all the cells of the arms and the legs, and indeed everywhere else in the body. All the cells are genetically programmed identically. Yet somehow they behave differently and form tissues and organs of different structures. Clearly some formative influence other than DNA must be shaping the developing arms and legs. All developmental biologists acknowledge this fact. But at this stage their mechanistic explanations peter out into vague statements about "complex spatio-temporal patterns of physico-chemical interaction not yet fully understood." Obviously this is not a solution but just another way of stating the problem.

Do you ever feel like you are giving far fewer fucks and yet still caring so much it sometimes feels like there is only the most tissue-thin layer separating your soul from this world? Like your heart may be broken but your spirit is still rising? Are you refusing to conform and somehow still fitting just right? Able to look people right in the eye without apology and also like you’re a teenager again, bashful and blushing and off-kilter, like that moment when lips unexpectedly pressed against your head and face buried in your hair fingers trailed down y our arm, the way your stomach can flip-flop like that, even now. Do you ever walk on purpose even when you have nowhere to go? Do you notice things deeply, like dark red lipstick prints on pristine white coffee mugs? Like the way whiskey burns and cool white sheets feel against your skin at the end of the day? Are you claiming your identity, clear and strong and true, and also sinking into the vast unknowable mystery of your all? Do your days feel like longing and acquiescence and learning to stop grasping at things that are ready to leave or that choose not to come closer? Are you making a home of your own skin and inviting the world inside? Are you learning that cultivating solid boundaries and driving into a wide open horizon both feel like freedom, like the harsh desert mountains and the soft ocean wisdom and the road to healing that joins the two? Does it all feels like solidity, like truth, like forgiveness and recklessness and heat and sexy and holy, all rolled up together? Do you crave the burn of heat from another and the for nothing to be louder than sound of your own heartbeat, all at once? Do you finally know that you can choose a love and a life that does not break you? That you can claim a softer beauty and a kinder want. That even your animal hunger can soften its rough edges and say a full-throated yes to what is good and kind and holy. Do you remember that insanity is not a prerequisite for passion and that there is another pathway to your art, one that does not demand your pain as payment for its own becoming? Are you learning to show up? To take up space? To feel the power? Is it full of contradiction, does it feel like fire underwater, are you rising to sing?

The SWAT team leader didn't like us cutting up the body. He and Ramirez went into a yelling match. While everyone was watching the argument, I nodded to Olaf and he beheaded the corpse in one blow. Blood gushed out onto the cave floor. "What the fuck are you doing?" one of the SWAT cops asked, bringing his gun pointed at us. "My job," I said. I put the tip of the blade under the ribs. The policeman brought the gun up to his shoulder. "Get away from the body until the captain tells you it's okay to do it." I kept the knife against the body. "Olaf." "Yes." "If he shoots me, kill him." "My pleasure." The big man turned his eyes to the policeman, and there was something in that gaze that made the heavily armed man take a step back. I plunged the blade into the skin, and it slid home. I cut a hole just below his ribs and reached into the hole. It was tight and wet and slick, and it took two hands to get the heart out, one to cut it free of the connecting tissue, and one to hold onto it. I drew it from the chest, blood stained to my elbows. I caught Ramirez and Bernardo both looking at me, with nearly identical looks on their faces. I didn't think either of them would be wanting a date any time soon. They'd always remember watching me cut a man's heart out, and that memory would stain anything else. With Bernardo, I didn't give a shit. With Ramirez, it hurt to see that look in his eyes. A hand touched the heart. I stared at that hand, then looked up to meet Olaf's eyes. He wasn't repulsed. He stroked the heart, hands sliding over mine. I pulled away, and we looked at each other over the body we'd butchered. No, Olaf wasn't repulsed. The look in his eyes was that pure darkness that only fills a man's eyes in the most intimate of situations. He raised the severed head up by the hair and held it almost as if he'd let me kiss it. Then I realized he was holding it over the heart, like a matched pair. I had to turn away from what I saw in his face.

I am speaking of the evenings when the sun sets early, of the fathers under the streetlamps in the back streets returning home carrying plastic bags. Of the old Bosphorus ferries moored to deserted stations in the middle of winter, where sleepy sailors scrub the decks, pail in hand and one eye on the black-and-white television in the distance; of the old booksellers who lurch from one ϧnancial crisis to the next and then wait shivering all day for a customer to appear; of the barbers who complain that men don’t shave as much after an economic crisis; of the children who play ball between the cars on cobblestoned streets; of the covered women who stand at remote bus stops clutching plastic shopping bags and speak to no one as they wait for the bus that never arrives; of the empty boathouses of the old Bosphorus villas; of the teahouses packed to the rafters with unemployed men; of the patient pimps striding up and down the city’s greatest square on summer evenings in search of one last drunken tourist; of the broken seesaws in empty parks; of ship horns booming through the fog; of the wooden buildings whose every board creaked even when they were pashas’ mansions, all the more now that they have become municipal headquarters; of the women peeking through their curtains as they wait for husbands who never manage to come home in the evening; of the old men selling thin religious treatises, prayer beads, and pilgrimage oils in the courtyards of mosques; of the tens of thousands of identical apartment house entrances, their facades discolored by dirt, rust, soot, and dust; of the crowds rushing to catch ferries on winter evenings; of the city walls, ruins since the end of the Byzantine Empire; of the markets that empty in the evenings; of the dervish lodges, the tekkes, that have crumbled; of the seagulls perched on rusty barges caked with moss and mussels, unϩinching under the pelting rain; of the tiny ribbons of smoke rising from the single chimney of a hundred-yearold mansion on the coldest day of the year; of the crowds of men ϧshing from the sides of the Galata Bridge; of the cold reading rooms of libraries; of the street photographers; of the smell of exhaled breath in the movie theaters, once glittering aϱairs with gilded ceilings, now porn cinemas frequented by shamefaced men; of the avenues where you never see a woman alone after sunset; of the crowds gathering around the doors of the state-controlled brothels on one of those hot blustery days when the wind is coming from the south; of the young girls who queue at the doors of establishments selling cut-rate meat; of the holy messages spelled out in lights between the minarets of mosques on holidays that are missing letters where the bulbs have burned out; of the walls covered with frayed and blackened posters; of the tired old dolmuşes, ϧfties Chevrolets that would be museum pieces in any western city but serve here as shared taxis, huϫng and puϫng up the city’s narrow alleys and dirty thoroughfares; of the buses packed with passengers; of the mosques whose lead plates and rain gutters are forever being stolen; of the city cemeteries, which seem like gateways to a second world, and of their cypress trees; of the dim lights that you see of an evening on the boats crossing from Kadıköy to Karaköy; of the little children in the streets who try to sell the same packet of tissues to every passerby; of the clock towers no one ever notices; of the history books in which children read about the victories of the Ottoman Empire and of the beatings these same children receive at home; of the days when everyone has to stay home so the electoral roll can be compiled or the census can be taken; of the days when a sudden curfew is announced to facilitate the search for terrorists and everyone sits at home fearfully awaiting “the oϫcials”; CONTINUED IN SECOND PART OF THE QUOTE

These autonomous, self-regulating properties of holons within the growing embryo are a vital safeguard; they ensure that whatever accidental hazards arise during development, the end-product will be according to norm. In view of the millions and millions of cells which divide, differentiate, and move about in the constantly changing environment of fluids and neighbouring tissues-Waddington called it 'the epigenetic landscape'-it must be assumed that no two embryos, not even identical twins, are formed in exactly the same way. The self-regulating mechanisms which correct deviations from the norm and guarantee, so to speak, the end-result, have been compared to the homeostatic feedback devices in the adult organism-so biologists speak of 'developmental homeostasis'. The future individual is potentially predetermined in the chromosomes of the fertilised egg; but to translate this blueprint into the finished product, billions of specialized cells have to be fabricated and moulded into an integrated structure. The mind boggles at the idea that the genes of that one fertilised egg should contain built-in provisions for each and every particular contingency which every single one of its fifty-six generations of daughter cells might encounter in the process. However, the problem becomes a little less baffling if we replace the concept of the 'genetic blueprint', which implies a plan to be rigidly copied, by the concept of a genetic canon of rules which are fixed, but leave room for alternative choices, i.e., flexible strategies guided by feedbacks and pointers from the environment. But how can this formula be applied to the development of the embryo?

Human bodies are extremely complicated and over the years I learned three important things about them, none of which I had been taught by lecturers or professors at my medical school. First, I learned that no two bodies are identical and there are an infinite number of variations. Not even twins are truly identical. When I first started to study medicine I used to think how much easier it would be for us all (doctors and patients) if bodies came with an owner's manual, but the more I learned about medicine the more I realised that such a manual would have to contain so many variations, footnotes and appendices that it wouldn't fit into the British Museum let alone sit comfortably on the average bookshelf. Even if manuals were individually prepared they would still be too vast for practical use. However much we may think we know about illness and health there will always be exceptions; there will always be times when our prognoses and predictions are proved wrong. Second, I learned that the human body has enormous, hidden strengths, and far greater power than most of us ever realise. We tend to think of ourselves as being delicate and vulnerable. But, in practice, our bodies are tougher than we imagine, far more capable of coping with physical and mental stresses than most of us realise. Very few of us know just how strong and capable we can be. Only if we are pushed to our limits do we find out precisely what we can do. Third, I learned that our bodies are far better equipped for selfdefence than most of us imagine, and are surprisingly well-equipped with a wide variety of protective mechanisms and self-healing systems which are designed to keep us alive and to protect us when we find ourselves in adverse circumstances. The human body is designed for survival and contains far more automatic defence mechanisms, designed to protect its occupant when it is threatened, than any motor car. To give the simplest of examples, consider what happens when you cut yourself. First, blood will flow out of your body for a few seconds to wash away any dirt. Then special proteins will quickly form a protective net to catch blood cells and form a clot to seal the wound. The damaged cells will release special substances into the tissues to make the area red, swollen and hot. The heat kills any infection, the swelling acts as a natural splint - protecting the injured area. White cells are brought to the injury site to swallow up any bacteria. And, finally, scar tissue builds up over the wounded site. The scar tissue will be stronger than the original, damaged area of skin. Those were the three medical truths I discovered for myself. Over the years I have seen many examples of these three truths. But one patient always comes into my mind when I think about the way the human body can defy medical science, prove doctors wrong and exhibit its extraordinary in-built healing power.

ERV envelope genes possess unique properties that make them suitable for use in forming the placenta: they are fusogenic proteins and they have immunosuppresive properties. Eutherian (placental) mammals distinguish themselves from nonplacental animals in the ability of the female to nurture the fertilized ovum and growing embryo within the body. The placenta is a transient tissue of embryonic origin whose evolution made it unnecessary to partition the embryo into a protective egg, which matured outside the mother's body. It serves two purposes for the maturing embryo: it is a conduit for respiratory gasses and nourishment supplied by the mother, and it provides an environment of immune tolerance. The fetus is necessarily half-foreign tissue, an allograft within the mother. It draws half of its genetic, and hence antigenic, identity from maternal and half from paternal genes. If the fetus is to mature within the mother, it must be isolated from the maternal immune system such that a graft-versus-host response does not reject it. The placenta forms early after implantation of the embryo. Syncytins mediate the formation of a continuous fused layer of cells around the embryo, isolating it from the mother, yet allowing essential nutrients to traverse from the mother's system. Although the observations on human syncytin-1 and -2 were compelling, it was left to scientists to definitively link syncytins to placental formation by studying mice. Here two syncytins (dubbed A and B) from murine ERVs were implicated, and genetic experiments with mice defective in these genes confirmed that their dysfunction disrupted placental formation. Notably, however, syncytin-A and -B were not syntenic with the human syncytins. That is, the human and mouse genes are not descended fron common ancestral syncytins; they have arisen by separate ERV gene capture events from different families of ERV in human and mouse ancestors.

Supported by love, any tissue-paper identity may stand like stone.

these creatures grow up with a peculiar knowledge. They know that they have been born in an infinite variety. They know, for instance, that in their genetic material they are born with hundreds of different chromosome formations at the point in each cell that we would say determines their "sex". These creatures don't just come in XX or XY; they also come in XXY and XYY and XXX plus a long list of "mosaic" variations in which some cells in a creature's body have one combination and other cells have another. Some of these creatures are born with chromosomes that aren't even quite X or Y because a little bit of one chromosome goes and gets joined to another. There are hundreds of different combinations, and though all are not fertile, quite a number of them are. The creatures in this world enjoy their individuality; they delight in the fact that they are not divisible into distinct categories. So when another newborn arrives with an esoterically rare chromosomal formation, there is a little celebration: "Aha," they say, "another sign that we are each unique." These creatures also live with the knowledge that they are born with a vast range of genital formations. Between their legs are tissue structures that vary along a continuum, from clitorises with a vulva through all possible combinations and gradations to penises with scrotal sac. These creatures live with an understanding that their genitals all developed prenatally from exactly the same little nub of embryonic tissue called a genital tubercle, which grew and developed under the influence of varying amounts of the hormone androgen. These creatures honor and respect everyone's natural-born genitalia –including what we would describe as a microphallus or a clitoris several inches long. What these creatures find amazing and precious is that because everyone's genitals stem from th same embryonic tissue, the nerves inside all their genitals got wired very much alike, so these nerves of touch just go crazy upon contact in a way that resonates completely between them. "My gosh," they think, "you must feel something in your genital tubercle that intensely resembles what I'm feeling in my genital tubercle." Well, they don't think that in so many words; they're actually quite heavy into their feelings at that point; but they do feel very connected –throughout all their wondrous variety. I could go on. I could tell you about the variety of hormones that course through their bodies in countless different patterns and proportions, both before birth and throughout their lives –the hormones that we call "sex hormones" but that they call "individuality inducers." I could tell you how these creatures think about reproduction: For part of their lives, some of these creatures are quite capable of gestation, delivery, and lactation; and for part of their lives, some of them are quite capable of insemination; and for part or all of their lives, some of them are not capable of any of those things – so these creatures conclude that it would be silly to lock anyone into a lifelong category based on a capability variable that may or may not be utilized and that in any case changes over each lifetime in a fairly uncertain and idiosyncratic way. These creatures are not oblivious to reproduction; but nor do they spend their lives constructing a self-definition around their variable reproductive capacities. They don't have to, because what is truly unique about those creatures is that they are capable of having a sense of personal identity without struggling to fit into a group identity based on how they were born. These creatures are quite happy, actually. They don't worry about sorting /other/ creatures into categories, so they don't have to worry about whether they are measuring up to some category they themselves are supposed to belong to.

Relying on traditional identity politics doesn’t work, he believes, because “labeling people is actually organized segregation.” Instead, viewing radicalization as stemming from isolation, he set out to strengthen Mechelen’s social connective tissue. In a hyperdiverse city, citizens needed to be allowed to thrive as multifaceted beings rather than simply be defined as “Muslim

The near absence of charts and tables from Freud’s scientific papers might be regarded as a peripheral matter if it weren’t symptomatic of a basic weakness of temperament: a lazy reluctance to collect sufficient evidence to ensure that a given finding wasn’t an anomaly or an artifact of careless procedures. This flaw could go unnoticed so long as Freud was microscopically analyzing dead tissues, any one of which could stand for countless identical others. For the purpose of establishing laws in most fields, though, large samples are indispensable. As a psychologist, Freud would consistently ignore that requirement. Instead, he would rest comprehensive generalizations on untested insights from a few cases or even from just one, his own.

The svara’s main function in Karnatik music is to give us a microcosm of the larger melody. But it cannot do this entirely on its own. It does so through a process of interaction. The svara, acts with other svaras to create smaller melodic units, which in turn define the larger melody. How does a svara, the ‘micro’, express the macro? It does so by representing an aspect of the larger melody, not by its fixity or rootedness, its immobility on a scale, but through its movable nature. Therefore, every svara can move, bounce, slide, glide, shiver or skip. How and to what extent a svara can be expressive depends on the nature of the larger musical identity it is part of and the nature of the other svaras within that macro identity. Svaras in some ways are like cells in a body. The cells (svaras) are determined by the content and function of the tissues (smaller melodic units), yet the larger human being (melody as a whole) is embedded in every cell, within the DNA.

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donated skeletal collection; one more skull was just a final drop in the bucket. Megan and Todd Malone, a CT technician in the Radiology Department at UT Medical Center, ran skull 05-01 through the scanner, faceup, in a box that was packed with foam peanuts to hold it steady. Megan FedExed the scans to Quantico, where Diana and Phil Williams ran them through the experimental software. It was with high hopes, shortly after the scan, that I studied the computer screen showing the features ReFace had overlaid, with mathematical precision, atop the CT scan of Maybe-Leoma’s skull. Surely this image, I thought—the fruit of several years of collaboration by computer scientists, forensic artists, and anthropologists—would clearly settle the question of 05-01’s identity: Was she Leoma or was she Not-Leoma? Instead, the image merely amplified the question. The flesh-toned image on the screen—eyes closed, the features impassive—could have been a department-store mannequin, or a sphinx. There was nothing in the image, no matter how I rotated it in three dimensions, that said, “I am Leoma.” Nor was there anything that said, “I am not Leoma.” To borrow Winston Churchill’s famous description of Russia, the masklike face on the screen was “a riddle wrapped in a mystery inside an enigma.” Between the scan, the software, and the tissue-depth data that the software merged with the

DELETING THE ZOMBIE SENESCENT CELLS IN OLD TISSUES. Thanks to the primordial survival circuit we’ve inherited from our ancestors, our cells eventually lose their identities and cease to divide, in some cases sitting in our tissues for decades. Zombie cells secrete factors that accelerate cancer, inflammation, and help turn other cells into zombies. Senescent cells are hard to reverse aging in, so the best thing to do is to kill them off. Drugs called senolytics are in development to do just that, and they could rapidly rejuvenate us.

Every multicellular organism begins as one cell, which contains all of the intricate instructions to synthesize, organize, and regulate not only this cell but the development and maintenance of all cells that will inevitably comprise the organism. All of these instructions are encoded in the first cell's DNA. This underscores the complexity of the genome and how each cell's expression must be controlled in specific ways depending on its function. The cells hailing from each tissue in the human body (e.g., muscle, lung, heart, liver) harbor a unique epigen­etic signature, which enables the maintenance of tissue-specific func­tions through the control of gene regulation, as just discussed. "Our knowledge of the total number of unique cells, or cell types, is still growing. Previous estimates put the number of unique cell types in the human body at ~300, but new estimates from the Human Cell Atlas have shown that we may have thousands of cell types and subtypes, each harboring a unique function for a specific physiological state or response to stimuli. But even cells of the same cell type will not be identical. A cell's 'presentation' of molecules on their surface can radi­cally change depending on internal variables such as genetic mutations or altered states of their epigenome, transcriptome, and proteome, as well as external stimuli including drugs and interactions with other cells. This novel presentation is most pronounced with a neoantigen, when a cancer cell creates an entirely new molecule on the surface of a cell. Given its unique presentation, which wouldn't be found in nor­mal cells, this offers a unique target for safer cancer therapies. "The human body has about 30 trillion human cells plus another 30-40 trillion bacterial cells, for a total of about 70 trillion cells. If your body were a democracy, the human cells would often be the minority or equal party. You (as a human) would never win an election. Your loss of control would likely result in you rolling around in the soil or lying in a bathtub full of yogurt, which I do sometimes on Sundays. Regard­less of how you spend your Sundays, there are a lot of microbes in, on, and around your body. There are in fact so many microbes that they compose the bulk of the cells on Earth. This is a humbling and exciting statistic, and one which is vividly apparent for anyone who has ever had explosive diarrhea.

P2 - We are well on the way in a number of areas. Both billionaires and big Pharma are getting increasingly interested and money is starting to pour into research because it is clear we can see the light at the end of the tunnel which to investors equates to return on investment. Numerous factors will drive things forward and interest and awareness is increasing rapidly among both scientists, researchers and the general population as well as wealthy philanthropists. The greatest driving force of all is that the baby boomers are aging and this will place increasing demands on healthcare systems. Keep in mind that the average person costs more in medical expenditure in the last year of their life than all the other years put together. Also, the number of workers is declining in most developed countries which means that we need to keep the existing population working and productive as long as possible. Below are a list which are basically all technologies potentially leading to radical life extension with number 5 highlighted which I assume might well be possible in the second half of the century: 1. Biotechnology - e.g stem cell therapies, enhanced autophagy, pharmaceuticals, immunotherapies, etc 2. Nanotechnology - Methods of repairing the body at a cellular and molecular level such as nanobots. 3. Robotics - This could lead to the replacement of increasing numbers of body parts and tends to go hand in hand with AI and whole brain emulation. It can be argued that this is not life extension and that it is a path toward becoming a Cyborg but I don’t share that view because even today we don’t view a quadriplegic as less human if he has four bionic limbs and this will hold true as our technology progresses. 4. Gene Therapies - These could be classified under the first category but I prefer to look at it separately as it could impact the function of the body in very dramatic ways which would suppress genes that negatively impact us and enhance genes which increase our tendency toward longer and healthier lives. 5. Whole brain emulation and mindscaping - This is in effect mind transfer to a non biological host although it could equally apply to uploading the brain to a new biological brain created via tissue engineering this has the drawback that if the original brain continues to exist the second brain would have a separate existence in other words whilst you are identical at the time of upload increasing divergence over time will be inevitable but it means the consciousness could never die provided it is appropriately backed up. So what is the chance of success with any of these? My answer is that in order for us to fail to achieve radical life extension by the middle of the century requires that all of the above technologies must also fail to progress which simply won't happen and considering the current rate of development which is accelerating exponentially and then factoring in that only one or two of the above are needed to achieve life extension (although the end results would differ greatly) frankly I can’t see how we can fail to make enough progress within 10-20 years to add at least 20 to 30 years to current life expectancy from which point progress will rapidly accelerate due to increased funding turning aging at the very least into a manageable albeit a chronic incurable condition until the turn of the 22nd century. We must also factor in that there is also a possibility that we could find a faster route if a few more technologies like CRISPR were to be developed. Were that to happen things could move forward very rapidly. In the short term I'm confident that we will achieve significant positive results within a year or two in research on mice and that the knowledge acquired will then be transferred to humans within around a decade. According to ADG, a dystopian version of the post-aging world like in the film 'In Time' not plausible in the real world: "If you CAREFULLY watch just the first

A living organism is primarily engaged in renewing itself, cells continuously breaking down and building up their structures, tissues and organs replacing their cells in continual cycles. While these continual structural changes take place, however, the organism maintains its identity and overall pattern of organization. This coexistence of stability and change is one of the hallmarks of life.

Aristotle (credited as the founder of logic) stated that the whole of logic is predicated on the Law of Non-Contradiction, that a thing is what it is and cannot be something else at the same time and in the same respect. In other words a muscle is a muscle—with its own distinct identity and qualities—it is not a mind, despite one popular bodybuilding “principle” of “muscle confusion.” Given that the principle of identity applied to human muscle tissue reveals that it cannot reason or properly use the principles of thought, one must wonder then how it might become confused.

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Thus, while basic emotional circuits are among the tools provided by nature, their ability to permanently change the life course and personalities of organisms depends on the nurturance or lack of nurturance that the world provides. In more precise scientific terms, everything we see is epigenetic, a mixture of nature and nurture. If you plant two identical tomato seeds in two different environments, you will have two plants of strikingly different size and overall shape, but they will still be discernibly tomato plants. There is no longer any question that brain tissues create the potential for having certain types of experiences, but there is also no doubt that the experiences, especially early ones, can change the fine details of the brain forever.