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The name itself is trouble. “Slough” means, literally, muddy field. A snake sloughs, or sheds, its dead skin. John Bunyan wrote of the “slough of despond” in Pilgrim’s Progress. In the 1930s, John Betjeman wrote this poem about Slough: Come friendly bombs and fall on Slough! It isn’t fit for humans now, There isn’t grass to graze a cow, Swarm over, Death! Then he got nasty. To this day, the residents of Slough rankle when anyone mentions the poem. The town’s reputation as a showpiece of quiet desperation was cemented when the producers of the TV series The Office decided to set the show in Slough.
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Eric Weiner (The Geography of Bliss: One Grump's Search for the Happiest Places in the World)