The Matrix Best Quotes

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Study yourself. Become your own mentor and best friend. When you are suffering stay at the bottom until you find out who you are. Let the storms come and pass. How you walk through the fire says a lot about you. Nobody likes a victimhood mentality and what happened to you is not important. It is about how you use your chaos that matters. The dawn will come
Mohadesa Najumi
You are not always right. It’s not always about being right. The best thing you can offer others is understanding. Being an active listener is about more than just listening, it is about reciprocating and being receptive to somebody else. Everybody has woes. Nobody is safe from pain. However, we all suffer in different ways. So learn to adapt to each person, know your audience and reserve yourself for people who have earned the depths of you
Mohadesa Najumi
I look upon ourselves as partners in all of this, and that each of us contributes and does what he can do best. And so I see not a top rung and a bottom rung - I see all this horizontally - and I see this as part of a matrix. And I see every human being as having a purpose, a destiny, if you like - the destiny that exists in each of us - and find ways and means to provide such opportunities for everyone.
Jonas Salk
Life is Beautiful? Beyond all the vicissitudes that are presented to us on this short path within this wild planet, we can say that life is beautiful. No one can ever deny that experiencing the whirlwind of emotions inside this body is a marvel, we grow with these life experiences, we strengthen ourselves and stimulate our feelings every day, in this race where the goal is imminent death sometimes we are winners and many other times we lose and the darkness surprises us and our heart is disconnected from this reality halfway and connects us to the server of the matrix once more, debugging and updating our database, erasing all those experiences within this caracara of flesh and blood, waiting to return to earth again. "Life is beautiful gentlemen" is cruel and has unfair behavior about people who looked like a bundle of light and left this platform for no apparent reason, but its nature is not similar to our consciousness and feelings, she has a script for each of us because it was programmed that way, the architects of the game of life they know perfectly well that you must experiment with all the feelings, all the emotions and evolve to go to the next levels. You can't take a quantum leap and get through the game on your own. inventing a heaven and a hell in order to transcend, that comes from our fears of our imagination not knowing what life has in store for us after life is a dilemma "rather said" the best kept secret of those who control us day by day. We are born, we grow up, we are indoctrinated in the classrooms and in the jobs, we pay our taxes, we reproduce, we enjoy the material goods that it offers us the system the marketing of disinformation, Then we get old, get sick and die. I don't like this story! It looks like a parody of Noam Chomsky, Let's go back to the beautiful description of beautiful life, it sounds better! Let's find meaning in all the nonsense that life offers us, 'Cause one way or another we're doomed to imagine that everything will be fine until the end of matter. It is almost always like that. Sometimes life becomes a real nightmare. A heartbreaking horror that we find impossible to overcome. As we grow up, we learn to know the dark side of life. The terrors that lurk in the shadows, the dangers lurking around every corner. We realize that reality is much harsher and ruthless than we ever imagined. And in those moments, when life becomes a real hell, we can do nothing but cling to our own existence, summon all our might and fight with all our might so as not to be dragged into the abyss. But sometimes, even fighting with all our might is not enough. Sometimes fate is cruel and takes away everything we care about, leaving us with nothing but pain and hopelessness. And in that moment, when all seems lost, we realize the terrible truth: life is a death trap, a macabre game in which we are doomed to lose. And so, as we sink deeper and deeper into the abyss, while the shadows envelop us and terror paralyzes us, we remember the words that once seemed to us so hopeful: life is beautiful. A cruel and heartless lie, that leads us directly to the tragic end that death always awaits us.
Marcos Orowitz (THE MAELSTROM OF EMOTIONS: A selection of poems and thoughts About us humans and their nature)
If everything we do and create is done to the best of our ability, then until we compare it to something else, how can it be anything less than great?
Gregg Braden (The Divine Matrix: Bridging Time, Space, Miracles, and Belief)
Want something true? - I killed god... ... Hahaha, look your face... you started believing me... whaterver to be honest god is the world best Illusion in this world "Matrix".
Deyth Banger (The Life of One Kid 1 (The Kid.D #7))
There’s no such thing in this world as absolute certainty. So accept that and go forward acting toward the best outcome no matter what.
Kenneth Atchity (The Messiah Matrix)
When The Matrix debuted in 1999, it was a huge box-office success. It was also well received by critics, most of whom focused on one of two qualities—the technological (it mainstreamed the digital technique of three-dimensional “bullet time,” where the on-screen action would freeze while the camera continued to revolve around the participants) or the philosophical (it served as a trippy entry point for the notion that we already live in a simulated world, directly quoting philosopher Jean Baudrillard’s 1981 reality-rejecting book Simulacra and Simulation). If you talk about The Matrix right now, these are still the two things you likely discuss. But what will still be interesting about this film once the technology becomes ancient and the philosophy becomes standard? I suspect it might be this: The Matrix was written and directed by “the Wachowski siblings.” In 1999, this designation meant two brothers; as I write today, it means two sisters. In the years following the release of The Matrix, the older Wachowski (Larry, now Lana) completed her transition from male to female. The younger Wachowski (Andy, now Lilly) publicly announced her transition in the spring of 2016. These events occurred during a period when the social view of transgender issues radically evolved, more rapidly than any other component of modern society. In 1999, it was almost impossible to find any example of a trans person within any realm of popular culture; by 2014, a TV series devoted exclusively to the notion won the Golden Globe for Best Television Series. In the fifteen-year window from 1999 to 2014, no aspect of interpersonal civilization changed more, to the point where Caitlyn (formerly Bruce) Jenner attracted more Twitter followers than the president (and the importance of this shift will amplify as the decades pass—soon, the notion of a transgender US president will not seem remotely implausible). So think how this might alter the memory of The Matrix: In some protracted reality, film historians will reinvestigate an extremely commercial action movie made by people who (unbeknownst to the audience) would eventually transition from male to female. Suddenly, the symbolic meaning of a universe with two worlds—one false and constructed, the other genuine and hidden—takes on an entirely new meaning. The idea of a character choosing between swallowing a blue pill that allows him to remain a false placeholder and a red pill that forces him to confront who he truly is becomes a much different metaphor. Considered from this speculative vantage point, The Matrix may seem like a breakthrough of a far different kind. It would feel more reflective than entertaining, which is precisely why certain things get remembered while certain others get lost.
Chuck Klosterman (But What If We're Wrong?: Thinking about the Present as If It Were the Past)
Based on its clear energetic signature as new technologies are breathlessly rolled out following a blatantly prewritten script, the current era might best be described as that of ‘Technotranshumanism.
Sol Luckman (Get Out of Here Alive: Inner Alchemy & Immortality)
Nash’s equilibrium, when it exists, is that point where neither player can do any better, or have no regrets, given what the opponent has done. Neither can have regrets because of how the other person played the game. It may not be the best option for either player, but it’s the best under the circumstances. There isn’t always an equilibrium in a game, or a Nash equilibrium in a game theory matrix. However, if it exists, in many cases the Nash equilibrium is a far better outcome for both players than the von Neumann saddle point. In the Kelley apartment cleaning game-theory matrices above, the Nash equilibrium is for them both to clean. Consider his payoffs. He does much better if he cleans no matter what she decides to do (because 5.7 is much greater than -2.2). Now consider her payoffs. She also does better if she cleans no matter what he does (because 8.5 is much greater than -6.6). So they have a stable Nash equilibrium at the joint strategy = (Male Cleans, Female Cleans). Then neither of them can have regrets about that choice because with that choice neither of them can do any better, regardless of what the partner does. With the Nash equilibrium their strategy is to maximize one’s own gains even if it means maximizing the partner’s gains (as well as one’s own).
John M. Gottman (The Science of Trust: Emotional Attunement for Couples)
This addition produces a two-by-two matrix: parenting is authoritative (high demand, high responsiveness), authoritarian (high demand, low responsiveness), permissive (low demand, high responsiveness), or neglectful (low demand, low responsiveness).
Robert M. Sapolsky (Behave: The Biology of Humans at Our Best and Worst)
Mr. Smith said it best in the Matrix: “I’d like to share a revelation that I have had during my time here, it came to me when I tried to classify your species, I realized that you are not actually mammals, every mammal on this planet instinctively develop a natural equilibrium with the surrounding environment but you humans do not, you move to an area and you multiply, multiply until every natural resource is consumed, the only way you can survive is to spread to another area. There is another organism on this planet that follows the same pattern, do you know what it is? A virus, human beings are a disease, a caner of this planet you are a plague we are the cure…
Lana Wachowski (The Matrix Screenplay)
Few arborists would suggest planting trees on a three-foot center, but if we planted our trees in groups of three or more on ten-foot centers, the resulting root matrix would keep them locked in place through thick and thin. None of the trees would develop into a single majestic specimen tree, but together they would form a single grove of trees that the eye will take in just as if they were one large tree. Planting tree groves will also protect against the domino effect. Every time we take down a tree, we make the remaining trees more vulnerable to straight-line winds. There is one catch to this approach, however: the trees must be planted young, so their roots can interlock as they grow.
Douglas W. Tallamy (Nature's Best Hope: A New Approach to Conservation that Starts in Your Yard)
The three conditions without which healthy growth does not take place can be taken for granted in the matrix of the womb: nutrition, a physically secure environment and the unbroken relationship with a safe, ever-present maternal organism. The word matrix is derived from the Latin for “womb,” itself derived from the word for “mother.” The womb is mother, and in many respects the mother remains the womb, even following birth. In the womb environment, no action or reaction on the developing infant’s part is required for the provision of any of his needs. Life in the womb is surely the prototype of life in the Garden of Eden where nothing can possibly be lacking, nothing has to be worked for. If there is no consciousness — we have not yet eaten of the Tree of Knowledge — there is also no deprivation or anxiety. Except in conditions of extreme poverty unusual in the industrialized world, although not unknown, the nutritional needs and shelter requirements of infants are more or less satisfied. The third prime requirement, a secure, safe and not overly stressed emotional atmosphere, is the one most likely to be disrupted in Western societies. The human infant lacks the capacity to follow or cling to the parent soon after being born, and is neurologically and biochemically underdeveloped in many other ways. The first nine months or so of extrauterine life seem to have been intended by nature as the second part of gestation. The anthropologist Ashley Montagu has called this phase exterogestation, gestation outside the maternal body. During this period, the security of the womb must be provided by the parenting environment. To allow for the maturation of the brain and nervous system that in other species occurs in the uterus, the attachment that was until birth directly physical now needs to be continued on both physical and emotional levels. Physically and psychologically, the parenting environment must contain and hold the infant as securely as she was held in the womb. For the second nine months of gestation, nature does provide a near-substitute for the direct umbilical connection: breast-feeding. Apart from its irreplaceable nutritional value and the immune protection it gives the infant, breast-feeding serves as a transitional stage from unbroken physical attachment to complete separation from the mother’s body. Now outside the matrix of the womb, the infant is nevertheless held close to the warmth of the maternal body from which nourishment continues to flow. Breast-feeding also deepens the mother’s feeling of connectedness to the baby, enhancing the emotionally symbiotic bonding relationship. No doubt the decline of breast-feeding, particularly accelerated in North America, has contributed to the emotional insecurities so prevalent in industrialized countries. Even more than breast-feeding, healthy brain development requires emotional security and warmth in the infant’s environment. This security is more than the love and best possible intentions of the parents. It depends also on a less controllable variable: their freedom from stresses that can undermine their psychological equilibrium. A calm and consistent emotional milieu throughout infancy is an essential requirement for the wiring of the neurophysiological circuits of self-regulation. When interfered with, as it often is in our society, brain development is adversely affected.
Gabor Maté (Scattered: How Attention Deficit Disorder Originates and What You Can Do About It)
Whether you believe in hell, whether you pray daily, whether you are a Catholic, Protestant, Jew, or Mormon ... none of these things correlated with generosity. The only thing that was reliably and powerfully associated with the moral benefits of religion was how enmeshed people were in relationships with their co-religionists. It's the friendships and group activities, carried out within a moral matrix that emphasizes selflessness. That's what brings out the best in people.
Jonathan Haidt (The Righteous Mind: Why Good People Are Divided by Politics and Religion)
Trees evolved to grow together in a forest. They intertwine their roots, forming a root matrix that is nearly impossible to uproot. Forest trees with interlocked roots may snap off in big winds, but they typically don’t uproot. Because aesthetics have trumped function for so long, we have planted large, isolated specimen trees ready to blow over nearly everywhere. If we change our goal from creating majestic specimen trees to picturesque groves of trees, the interlocking effect of root matrices will be strongest.
Douglas W. Tallamy (Nature's Best Hope: A New Approach to Conservation that Starts in Your Yard)
In their book American Grace: How Religion Divides and Unites Us, political scientists Robert Putnam and David Campbell analyzed a variety of data sources to describe how religious and nonreligious Americans differ. Common sense would tell you that the more time and money people give to their religious groups, the less they have left over for everything else. But common sense turns out to be wrong. Putnam and Campbell found that the more frequently people attend religious services, the more generous and charitable they become across the board.58 Of course religious people give a lot to religious charities, but they also give as much as or more than secular folk to secular charities such as the American Cancer Society.59 They spend a lot of time in service to their churches and synagogues, but they also spend more time than secular folk serving in neighborhood and civic associations of all sorts. Putnam and Campbell put their findings bluntly: By many different measures religiously observant Americans are better neighbors and better citizens than secular Americans—they are more generous with their time and money, especially in helping the needy, and they are more active in community life.60 Why are religious people better neighbors and citizens? To find out, Putnam and Campbell included on one of their surveys a long list of questions about religious beliefs (e.g., “Do you believe in hell? Do you agree that we will all be called before God to answer for our sins?”) as well as questions about religious practices (e.g., “How often do you read holy scriptures? How often do you pray?”). These beliefs and practices turned out to matter very little. Whether you believe in hell, whether you pray daily, whether you are a Catholic, Protestant, Jew, or Mormon … none of these things correlated with generosity. The only thing that was reliably and powerfully associated with the moral benefits of religion was how enmeshed people were in relationships with their co-religionists. It’s the friendships and group activities, carried out within a moral matrix that emphasizes selflessness. That’s what brings out the best in people. Putnam and Campbell reject the New Atheist emphasis on belief and reach a conclusion straight out of Durkheim: “It is religious belongingness that matters for neighborliness, not religious believing.”61
Jonathan Haidt (The Righteous Mind: Why Good People are Divided by Politics and Religion)
One day in the dojo (the martial-arts studio) before our karate class began, I witnessed the power of a concentrated focus unlike anything that I’d ever seen growing up in the heartland of northern Missouri. On that day, our instructor walked into the room and asked us to do something very different from the form and movement practices that were familiar to us. He explained that he would seat himself in the center of the thick mat where we honed our skills, close his eyes, and go into a meditation. During this exercise, he would stretch his arms out on either side of his body, with his palms open and facedown. He asked us to give him a couple of minutes to “anchor” himself in this T position and then invited us to do anything that we could to move him from his place. The men in our class outnumbered the women by about two to one, and there had always been a friendly competition between the sexes. On that day, however, there was no such division. Together, we all sat close to our instructor, silent and motionless. We watched as he simply walked to the center of the mat, sat down with his legs crossed, closed his eyes, held out his arms, and changed his breathing pattern. I remember that I was fascinated and observed closely as his chest swelled and shrank, slower and slower with each breath until it was hard to tell that he was breathing at all. With a nod of agreement, we moved closer and tried to move our instructor from his place. At first, we thought that this was going to be an easy exercise, and only a few of us tried. As we grabbed his arms and legs, we pushed and pulled in different directions with absolutely no success. Amazed, we changed our strategy and gathered on one side of him to use our combined weight to force him in the opposite direction. Still, we couldn’t even budge his arms or the fingers on his hands! After a few moments, he took a deep breath, opened his eyes, and with the gentle humor we’d come to respect, he asked, “What happened? How come I’m still sitting here?” After a big laugh that eased the tension and with a familiar gleam in his eyes, he explained what had just happened. “When I closed my eyes,” he said, “I had a vision that was like a dream, and that dream became my reality. I pictured two mountains, one on either side of my body, and myself on the ground between the peaks.” As he spoke, I immediately saw the image in my mind’s eye and felt that he was somehow imbuing us with a direct experience of his vision. “Attached to each of my arms,” he continued, “I saw a chain that bound me to the top of each mountain. As long as the chains were there, I was connected to the mountains in a way that nothing could change.” Our instructor looked around at the faces that were riveted on each word he was sharing. With a big grin, he concluded, “Not even a classroom full of my best students could change my dream.” Through a brief demonstration in a martial-arts classroom, this beautiful man had just given each of us a direct sense of the power to redefine our relationship to the world. The lesson was less about reacting to what the world was showing us and more about creating our own rules for what we choose to experience. The secret here is that our instructor was experiencing himself from the perspective that he was already fixed in one place on that mat. In those moments, he was living from the outcome of his meditation. Until he chose to break the chains in his imagination, nothing could move him. And that’s precisely what we found out.
Gregg Braden (The Divine Matrix: Bridging Time, Space, Miracles, and Belief)
Here’s a research study that shows just how differently teens’ brains function: In a Magnetic Resonance Imaging (MRI) study, teenagers and adults were presented pictures of people who looked scared or anxious. The adults recognized the fear in the faces but placed the experiences in a larger context, so it didn’t affect them personally. The opposite was true of the teens: they did not report that the faces were fearful, but they became emotionally involved and reported more fear and anxiety themselves. In teens, the parts of the brain that process gut reactions and primitive emotions — the amygdala and insula — were active. But in adults, the frontal lobes were activated as well. In other words, the teenagers’ brains responded emotionally. They felt upset but their brains did not identify the source of those feelings. The adults’ brains added reason to that response. Remember this when your teen gets upset “for no reason.” He may not be able to say why he’s feeling that way, but his feelings are still valid. He doesn’t have the connections between his rational brain and his emotional brain that would allow him to explain it. Logic doesn’t help because the teen’s brain cannot follow abstract logic. They are doing the best they can with the brain connections they have. This is especially true if your teen is a boy. As we see later, girls have more connections between their emotional and executive centers. Astrocytes: Functional and structural support Astrocytes are another class of glial cells. They are star-shaped, hence their name, and provide structural and functional support for the neuron. Astrocytes form the matrix that keeps neurons in place. But they are more than inert bricks in a passive wall. Rather, they function more like the mother who ensures her children have brushed their teeth, are wearing their coats in winter, and are eating good meals. An astrocyte is pictured in Figure 3.3. Astrocytes sit between blood vessels and neurons and breakdown glucose from the capillaries into lactic acid, which the mitochondria of the neurons use for energy. As a wise mother, they do not break down all of the glycogen they receive from the blood, but create a reserve for times when the metabolic need of neurons are especially high.
Frederick Travis (Your Brain Is a River, Not a Rock)
Fine then, she thinks with bitterness. She will stay in this wretched place and make the best of the life given her. She will do all that she can do to exalt herself on this worldly plane. She will make those who cast her out sorry for what they’ve done. One day they will see the majesty she holds within herself and feel awe.
Lauren Groff (Matrix)
Perhaps the song of a bird in a chamber is more precious than the wild bird’s because the chamber itself makes it so. Perhaps the free air that gives the wild bird its better song in fact limits the reach of its prayer. So small, this understanding. So remarkably tiny. Still, it might be enough to live for. Fine then, she thinks with bitterness. She will stay in this wretched place and make the best of the life given her. She will do all that she can do to exalt herself on this worldly plane. She will make those who cast her out sorry for what they’ve done. One day they will see the majesty she holds within herself and feel awe.
Lauren Groff (Matrix)
It was an epiphany that would propel other 1999 films such as Fight Club, The Matrix, and American Beauty—stories in which the heroes abandon their jobs before finding themselves.
Brian Raftery (Best. Movie. Year. Ever.: How 1999 Blew Up the Big Screen)
The Matrix was ten years ahead of its time,” says Run Lola Run’s Tom Tykwer, who cites the film as the first to truly understand the way the online world was becoming “our second home.
Brian Raftery (Best. Movie. Year. Ever.: How 1999 Blew Up the Big Screen)
There’d been so many dynamic films in 1999 that viewers would need time to fully absorb what had happened, and many of the year’s commercial letdowns enjoyed remarkable afterlives. The exploding DVD and cable TV markets that revived Office Space and Fight Club would resuscitate many of the year’s commercial failures. They’d also ensure that hits such as The Matrix and The Sixth Sense would appear on late-night TV for years on end, their various body bends and plot twists becoming familiar to even the most casual film viewers.
Brian Raftery (Best. Movie. Year. Ever.: How 1999 Blew Up the Big Screen)
If The Matrix and Being John Malkovich were being pitched today,” says Cho, “they’d be pitched as television shows.
Brian Raftery (Best. Movie. Year. Ever.: How 1999 Blew Up the Big Screen)
In the midnineties, similar state-of-the-art grumblings had worked their way through backlots, theater lines, and magazine meeting rooms. They shared the same deep concern: the movies were in a spiritual crisis. Studios had become obsessed with pointless remakes and retreads. Young people, meanwhile, were spending more of their time and money on at-home distractions such as video games. And TV was threatening to siphon all of Hollywood’s power: in October 1995, Entertainment Weekly’s cover story offered “10 Reasons Why Television Is Better Than the Movies,” citing such hits as Friends and ER. The industry needed something new. As one anonymous studio executive said at the time, “We’re making a lot of movies that people don’t want to see.” At that exact moment, the Wachowskis were sprucing up The Matrix.
Brian Raftery (Best. Movie. Year. Ever.: How 1999 Blew Up the Big Screen)
If The Matrix and Being John Malkovich were being pitched today,” says Cho, “they’d be pitched as television shows.” Cho, like many actors of his generation, now works in both film and television—a situation that some performers didn’t find too satisfying in 1999. “Television used to be the graveyard for filmmakers, actors, and writers,” notes Brendan Fraser, who earned some of the best reviews of his career for the small-screen roles he took on starting in the midaughts.
Brian Raftery (Best. Movie. Year. Ever.: How 1999 Blew Up the Big Screen)
Many of the one-liners teach volumes. Some summarize excellence in an entire field in one sentence. As Josh Waitzkin (page 577), chess prodigy and the inspiration behind Searching for Bobby Fischer, might put it, these bite-sized learnings are a way to “learn the macro from the micro.” The process of piecing them together was revelatory. If I thought I saw “the Matrix” before, I was mistaken, or I was only seeing 10% of it. Still, even that 10%—“ islands” of notes on individual mentors—had already changed my life and helped me 10x my results. But after revisiting more than a hundred minds as part of the same fabric, things got very interesting very quickly. For the movie nerds among you, it was like the end of The Sixth Sense or The Usual Suspects: “The red door knob! The fucking Kobayashi coffee cup! How did I not notice that?! It was right in front of me the whole time!” To help you see the same, I’ve done my best to weave patterns together throughout the book, noting where guests have complementary habits, beliefs, and recommendations. The completed jigsaw puzzle is much greater than the sum of its parts.
Timothy Ferriss (Tools of Titans: The Tactics, Routines, and Habits of Billionaires, Icons, and World-Class Performers)
FUNCTIONAL SAFETY AS PER IEC 61511 SIF SIS SIL TRAINING FUNCTIONAL SAFETY COURSE OBJECTIVES: The main objective of this training program is to give engineers involved in safety instrumented systems the opportunity to learn about functional safety, current applicable safety standards (IEC 61511) and their requirements. The Participants will be able to learn to follow: • Understand the basic requirements of the functional safety standards (IEC 61511) • The meaning of SIS, SIF, SIL and other functional safety terminology • Differentiate between safety functions and control functions • The role of Hazard and Risk analysis in setting SIL targets• • Create basic designs of safety instrumented systems considering architectural constraints • Different type of failures and best practices for minimizing them • Understand the effect of redundancy, diagnostics, proof test intervals, hardware fault tolerance on the SIL • The responsibility of operation and maintenance to ensure a SIF meets its SIL • How to proof test a SIF The Benefits for the Participants: At the conclusion of the training, the participants will be able to: Participate effectively in SIL determination with Risk graph, Risk matrix, and LOPA methodology Determine whether the design of a Safety Instrumented Function meets the required SIL. Select a SIF architecture that both meets the required SIL and minimizes spurious trips. Select SIF components to meet the target SIL for that SIF Target Audience: Instrument and Control Design and maintenance engineers Process Engineers Process Plant Operation Engineers Functional safety Management Engineers For Registration Email Us On techsupport@marcepinc.com or call us on 022-30210100
Amin Badu
Metabolic networks remain the only class of biological network reconstructed reasonably comprehensively at the genome-scale in humans. Given that metabolic networks are ultimately based on directed chemical reactions that obey the laws of mass and energy balance, they can further serve the basis for calculations to predict reaction rates (metabolic flux). These fluxes can subsequently be used to compute productions and growth rates of metabolites. In flux balance analysis, the set of reactions is formulated as a stochiometric matrix, which enumerates the ratios of metabolite participation in each reaction. A set of physically possible reaction flux rates result by enforcing a steady-state mass balance (homeostasis) and additional constraints on reaction reversabilities and maximal conversion rates. From within the space of chemically feasible reaction flux combinations, the subset of biologically relevant reaction flux profiles can be solved by optimizing an objective function. The most commonly used objective function in microbes has been to maximize the production of biomass, which serves as a proxy for maximizing growth rate. Notably, while maximal growth may be an appropriate assumption for diseases such as cancer under certain conditions, the best cellular objective function to simulate many human tissues and cell types is unknown (and is likely condition-specific). Adjusting this objective function, which was developed based on microbial physiology, to better reflect human tissues is an area of active research.
Joseph Loscalzo (Network Medicine: Complex Systems in Human Disease and Therapeutics)