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In the brain, a storm comes in the form of gunk, or plaque, that builds up to interfere with the connection of cells. That plaque comes from brain waste (yes, all organs have waste). Some of it is called tau protein; some is called beta-amyloid, or sometimes limbic-predominant age-related TDP-43.1 Essentially, this cell waste attracts inflammation; the buildup disrupts the brain’s connections by gobbling them up and reducing their size, as a storm tangles tree branches and makes power lines ineffective.
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Michael F. Roizen (The Great Age Reboot: Cracking the Longevity Code for a Younger Tomorrow)