Targeted Therapies Quotes

My brain has always been my enemy, and I’ve spent much of the past decade warring against it, with therapy and razor blades and bad behavior, with precision-guided prescriptions that targeted specific regions.

Specificity refers to the ability of any medicine to discriminate between its intended target and its host. Killing a cancer cell in a test tube is not a particularly difficult task: the chemical world is packed with malevolent poisons that, even in infinitesimal quantities, can dispatch a cancer cell within minutes. The trouble lies in finding a selective poison—a drug that will kill cancer without annihilating the patient. Systemic therapy without specificity is an indiscriminate bomb. For an anticancer poison to become a useful drug, Meyer knew, it needed to be a fantastically nimble knife: sharp enough to kill cancer yet selective enough to spare the patient.

I may have no emotional skin and come undone at the smallest interpersonal upset, but I’d make a great bullfighter or firefighter—anything that gets my adrenaline going and focuses me on a physical target. The motorcycle is all of that and more. When I’m on the bike, it feels like a door opens in my chest and the world rushes in, pure, fresh, and sparkling with clarity. It forces me to approach fear with total awareness and to pull reason mind into the moment of intense reactions.

Humans do not benefit but are harmed by misleading animal testing, especially when it comes to predicting the efficacy of targeted therapies.

The act of consciously and purposefully paying attention to symptoms and their antecedents and consequences makes the symptoms more an objective target for thoughtful observation than an intolerable source of subjective anxiety, dysphoria, and frustration. In ACT, the act of accepting the symptoms as an expectable feature of a disorder or illness, has been shown to be associated with relief rather than increased distress (Hayes et al., 2006). From a traumatic stress perspective, any symptom can be reframed as an understandable, albeit unpleasant and difficult to cope with, reaction or survival skill (Ford, 2009b, 2009c). In this way, monitoring symptoms and their environmental or experiential/body state "triggers" can enhance client's willingness and ability to reflectively observe them without feeling overwhelmed, terrified, or powerless. This is not only beneficial for personal and life stabilization but is also essential to the successful processing of traumatic events and reactions that occur in the next phase of therapy (Ford & Russo, 2006).

KF: This is sounding like it’s something akin to a cure; is that the case? TCC: Yes. The problem in this area of medicine is that traditional doctors are so focused on the use of targeted therapies (chemo, surgery, radiation) that they refuse to even acknowledge the use of therapies like nutrition and are loath to even do proper research in this area. So, in spite of the considerable evidence—theoretical and practical—to support a beneficial nutritional effect, every effort will be made to discredit it. It’s a self-serving motive.

Cancer is not the only brain disease being targeted for treatment with living cells. Cell therapy also has the potential to replace aging or injured tissue. In this hope for regenerative medicine, modified stem cells are being studied as a treatment for Alzheimer’s disease.

Running held a prominent place in my mental health kit, as essential as medication and therapy. Running reduced the number of naps I took, increased my self-esteem, made me more accountable, prevented my psychiatrist from having to increase or change my medication, and likely kept me out of the hospital, but it hadn’t cured me.

The words are ludicrous, but not if it's you they're talking about, not if it's you they're locking up. Not ludicrous at all for the ones who continue to be diagnosed as mentally ill. A mouthy girl in cow boy boots or a boy who drapes a scarf on his head to pretend his hair is long like a princess – well, they are targets for the Dr. Madisons of the world.

change, even a tiny one, in the way we manage our thoughts and perceive and interpret the world can significantly change our existence. Changing the way we experience transitory emotions leads to a change in our moods and to a lasting transformation of our way of being. Such “therapy” targets the sufferings that afflict most of us and seeks to promote the optimal flourishing of the human being.

(IMRT) has an advantage. The newer, high-dose, conformally directed, external-beam techniques for radiation therapy such as IMRT have been in widespread use for less than ten years; IGRT has been around for an even shorter time. However, some reports of long-term success are now emerging. New studies suggest that at ten years, high radiation doses alone can produce PSA control or cure rates in 93 percent of men with low-risk prostate cancer. What about more aggressive prostate cancer? As we discussed in chapter 9, the best treatment regimen for men with intermediate- and high-risk prostate cancer is still a moving target, but it will likely turn out to be a combination of high-dose radiation and short- or long-term hormonal therapy.

When one of my early teachers, for instance, recognized that many ritually abused clients were still being abused while in treatment, she insisted that they could not be treated on an outpatient basis, but should be hospitalized and kept from their families. She was targeted with a series of court cases involving false accusations that she had allegedly abused clients in hospital. The experience was devastating to her. And she was not alone. Many others faced persistent attempts to discredit their professional expertise, or legal assaults that robbed them of time, energy, and even the courage to continue to treat clients, write, or teach. Therapy professionals in both direct services and policy making, members of the criminal and civil justice systems, and the general public were systematically indoctrinated via the media. Many now share the view that people who disclose ritual abuse or mind control content suffer from "false memories” induced by "over-zealous therapists," and that dissociative disorders are iatrogenic (or else they do not exist at all).

For things to change, somebody somewhere has to start acting differently. Maybe it’s you, maybe it’s your team. Picture that person (or people). Each has an emotional Elephant side and a rational Rider side. You’ve got to reach both. And you’ve also got to clear the way for them to succeed. In short, you must do three things: → DIRECT the Rider FOLLOW THE BRIGHT SPOTS. Investigate what’s working and clone it. [Jerry Sternin in Vietnam, solutions-focused therapy] SCRIPT THE CRITICAL MOVES. Don’t think big picture, think in terms of specific behaviors. [1% milk, four rules at the Brazilian railroad] POINT TO THE DESTINATION. Change is easier when you know where you’re going and why it’s worth it. [“You’ll be third graders soon,” “No dry holes” at BP] → MOTIVATE the Elephant FIND THE FEELING. Knowing something isn’t enough to cause change. Make people feel something. [Piling gloves on the table, the chemotherapy video game, Robyn Waters’s demos at Target] SHRINK THE CHANGE. Break down the change until it no longer spooks the Elephant. [The 5-Minute Room Rescue, procurement reform] GROW YOUR PEOPLE. Cultivate a sense of identity and instill the growth mindset. [Brasilata’s “inventors,” junior-high math kids’ turnaround] → SHAPE the Path TWEAK THE ENVIRONMENT. When the situation changes, the behavior changes. So change the situation. [Throwing out the phone system at Rackspace, 1-Click ordering, simplifying the online time sheet] BUILD HABITS. When behavior is habitual, it’s “free”—it doesn’t tax the Rider. Look for ways to encourage habits. [Setting “action triggers,” eating two bowls of soup while dieting, using checklists] RALLY THE HERD.

It's possible to see how much the brand culture rubs off on even the most sceptical employee. Joanne Ciulla sums up the dangers of these management practices: 'First, scientific management sought to capture the body, then human relations sought to capture the heart, now consultants want tap into the soul... what they offer is therapy and spirituality lite... [which] makes you feel good, but does not address problems of power, conflict and autonomy.'¹0 The greatest success of the employer brand' concept has been to mask the declining power of workers, for whom pay inequality has increased, job security evaporated and pensions are increasingly precarious. Yet employees, seduced by a culture of approachable, friendly managers, told me they didn't need a union - they could always go and talk to their boss. At the same time, workers are encouraged to channel more of their lives through work - not just their time and energy during working hours, but their social life and their volunteering and fundraising. Work is taking on the roles once played by other institutions in our lives, and the potential for abuse is clear. A company designs ever more exacting performance targets, with the tantalising carrot of accolades and pay increases to manipulate ever more feverish commitment. The core workforce finds itself hooked into a self-reinforcing cycle of emotional dependency: the increasing demands of their jobs deprive them of the possibility of developing the relationships and interests which would enable them to break their dependency. The greater the dependency, the greater the fear of going cold turkey - through losing the job or even changing the lifestyle. 'Of all the institutions in society, why let one of the more precarious ones supply our social, spiritual and psychological needs? It doesn't make sense to put such a large portion of our lives into the unsteady hands of employers,' concludes Ciulla. Life is work, work is life for the willing slaves who hand over such large chunks of themselves to their employer in return for the paycheque. The price is heavy in the loss of privacy, the loss of autonomy over the innermost workings of one's emotions, and the compromising of authenticity. The logical conclusion, unless challenged, is capitalism at its most inhuman - the commodification of human beings.

To get the most out of this chapter, first find where you are on this map of the cancer journey: Critical stress points. When you have just been diagnosed with cancer or learned that your cancer has recurred or is not responding to treatment. Treatment preparation. When you are anticipating surgery, radiation, chemotherapy, or molecular target therapies. Side effect management. When you are undergoing treatment and need ways (instead of or in addition to drugs) to manage its side effects. Post-treatment. When you are adjusting to the end of active treatment, usually after the final chemotherapy cycle. This situation can, perhaps surprisingly, prove quite stressful. Remission maintenance. Although definitely good news, remission introduces its own issues, most notably fear of recurrence. Remission is also when you will be most determined to take back your life from cancer.

The choice to favor LDL-cholesterol over HDL-cholesterol was also probably fueled by the megabillion-dollar pharmaceutical industry, which heavily favored LDL-cholesterol as a target for therapy.

Framingham group in 1977, as you might remember, plus a number of other studies, suggested that total cholesterol was not, actually, a good predictor of heart disease for most people. That was not a result anyone wanted to trumpet too loudly, of course, since it thoroughly undermined the diet-heart hypothesis, which had made total cholesterol-lowering the chief target for all its therapies for decades.

Activation of the androgen receptor (AR) is crucial for tumor cell progression and survival of prostate cancer, and androgen deprivation therapy remains the main clinical approach in men with locally advanced tumors ■ Current therapies incompletely suppress the androgen–AR axis, but a multiple therapeutic approach, targeting androgens and their receptor, has potential to improve clinical outcomes ■ Treatment of prostate cancer cells with 5α-reductase inhibitors (5ARIs) inhibits cellular pathways regulating metabolism, cell growth and proliferation, triggering apoptosis and decreasing prostate size ■ Although 5ARI treatment reduces the risk of developing prostate cancer, patients treated with these drugs have tumors with higher Gleason scores than those who receive placebo ■ Use of 5ARIs to prevent and treat prostate cancer remains controversial, and further investigation is necessary to understand the presence of more-aggressive tumors in patients receiving these drugs

exposure treatment principles of behavioral therapy, in which a person’s phobic response gradually extinguishes itself when the subject learns the target stimulus does not produce the harm originally feared.

Let me begin by saying that no, I am not crazy. I had no intention of initiating this little trauma with one child while giving birth to another. In fact, I was thinking middle school was probably a good target for the whole process. But he, apparently, had other plans. "I go potty!" he said. We were standing at the sink brushing our teeth. "What?" I asked, looking around to see if there was someone else in the room. "I go potty!" he said again. He got down from his little stepstool and stood adamantly before the toilet. "Well, OK, little guy," I replied, hesitantly, "I mean, sure, if that's what you want to do . . . " I certainly couldn't discourage him without being the focus of therapy for years to come. And besides, what kind of mother says, "No, honey, I'd really rather you stayed in diapers until you're old enough to date"? I dutifully took off his diaper and pants, popped in his little potty seat, and lifted him up. "All done!" he squealed with delight. "What?" I practically screamed. "What do you mean, all done? You haven't been up there ten seconds!" "All done!" he said again, and started to hop down. He stood there in the middle of the bathroom, looking very proud of himself, and proceeded to pee on the floor. OK, I said to myself. It's just going to take some time. "Good job, honey! Nice try! We'll get 'em next time!" I said cheerfully. I then put a clean diaper on him, put his pants back on, cleaned up the floor, and started down the stairs. "I go potty!" he called after me. "I go potty again!

no patients with solid tumors have been cured by targeted therapies over that time period. Zero [is] the number of targeted therapies that have prolonged survival by one year, when compared to a conventional treatment.

Worst Comes To Worst" (feat. Guru) [Babu mixing] "Worst come to worst my peoples come first" "Worst...come.....to worst" "Worst come to worst my peoples come first" "Worst come...to...worst" "Worst come to worst my peoples come first" [Evidence talking] Yeah It's goin down y'all That's Babu Yo, some people got good friends, at night I live my life right Intense, on the edge On the wild, I'm from the group where friction leads to fire Stack your bricks, the time is take your pick Do or don't, the track - Alchemist My life is good, I got my peeps in the mix, so... "Worst come to worst my people come first" [Iriscience] I got worldwide family all over the earth And I worry 'bout 'em all for whatever it's worth From the birth to the hearse, the streets, the guns burst Words I disperse are here to free minds And if mine are needy I need to feed mine "When worst come to worst..." [Evidence] Set up shop and write a verse Actually (what?), that's best come to best My lyrics take care of me, they therapy Get shit off my chest Extra stress, three-four over the score Different patterns of rhymin prepare me for war So next time you see us we'll be deadly on tour [Babu mixing] "Oh, when you need me" "Worst come to worst my peoples come first" [Guru talking] Word up, if worst comes to worst, I make whole crews disperse You know it's family first Gifted Unlimited with Dilated Peoples Babu, Evidence, Iriscience And a shout out to my man Alchemist on the trizzack "Oh, when you need me" "Worst come to worst my peoples come first" [Iriscience] I'm a glutton for the truth, even though truth hurts I've studied with my peoples on streets and in church We make it hard when we go on first Long road, honor of the samurai code These California streets ain't paved with gold Worst comes to worst "Worst come to worst my people come first" [Evidence] Uh, I got them back, at the end of the day We could go our seperate ways but the songs remains, it won't change Got my target locked at range I might switch gears but first I switch lanes Without my people I got nothin to gain That's why... "Worst come to worst my people come first" [Iriscience] Special victims unit, catalyst for movement Creates to devastate, since '84 show improvement Definitely Dilated Peoples comes first Cross-trainin spar, we raise the bar And we put it in your ear no matter who you are [Babu mixing] "Oh, when you need me" "Worst come to worst my peoples come first" "Worst....come...worst my peoples come first" "Worst...worst....worst....come to worst my peoples come first" "...my..my...my peoples come first "Oh, when you need me

It has been said that if a drug has no side effects, then it is unlikely to work. Drug therapy labours under the fundamental problem that usually every single cell in the body has to be treated just to exert a beneficial effect on a small group of cells, perhaps in one tissue. Although drug-targeting technology is improving rapidly, most of us who take an oral dose are still faced with the problem that the vast majority of our cells are being unnecessarily exposed to an agent that at best will have no effect, but at worst will exert many unwanted effects. Essentially, all drug treatment is really a compromise between positive and negative effects in the patient.

For things to change, somebody somewhere has to start acting differently. Maybe it’s you, maybe it’s your team. Picture that person (or people). Each has an emotional Elephant side and a rational Rider side. You’ve got to reach both. And you’ve also got to clear the way for them to succeed. In short, you must do three things: → DIRECT the Rider FOLLOW THE BRIGHT SPOTS. Investigate what’s working and clone it. [Jerry Sternin in Vietnam, solutions-focused therapy] SCRIPT THE CRITICAL MOVES. Don’t think big picture, think in terms of specific behaviors. [1% milk, four rules at the Brazilian railroad] POINT TO THE DESTINATION. Change is easier when you know where you’re going and why it’s worth it. [“You’ll be third graders soon,” “No dry holes” at BP]               → MOTIVATE the Elephant FIND THE FEELING. Knowing something isn’t enough to cause change. Make people feel something. [Piling gloves on the table, the chemotherapy video game, Robyn Waters’s demos at Target] SHRINK THE CHANGE. Break down the change until it no longer spooks the Elephant. [The 5-Minute Room Rescue, procurement reform] GROW YOUR PEOPLE. Cultivate a sense of identity and instill the growth mindset. [Brasilata’s “inventors,” junior-high math kids’ turnaround]                             → SHAPE the Path TWEAK THE ENVIRONMENT. When the situation changes, the behavior changes. So change the situation. [Throwing out the phone system at Rackspace, 1-Click ordering, simplifying the online time sheet] BUILD HABITS. When behavior is habitual, it’s “free”—it doesn’t tax the Rider. Look for ways to encourage habits. [Setting “action triggers,” eating two bowls of soup while dieting, using checklists] RALLY THE HERD. Behavior is contagious. Help it spread. [“Fataki” in Tanzania, “free spaces” in hospitals, seeding the tip jar] ————— OVERCOMING OBSTACLES ————— Here we list twelve common problems that people encounter as they fight for change, along with some advice about overcoming them. (Note

The incidence of CML remains unchanged from the past: only a few thousand patients are diagnosed with this form of leukemia every year. "But the prevalence of CML---the number of patients presently alive with the disease---has dramatically changed with the introduction of Gleevec.  As of 2009, CML patients treated with Gleevec survive an average of thirty years after their initial diagnosis.  Based on that survival figure, Hagop Kantarjian estimates that within the next decade, 250,000 people will be living with CML in America, all of them on targeted therapy.  Druker's drug will alter the national physiognomy of cancer, converting a once-rare disease into a relatively common one.  (Druker jokes that he has achieved the perfect inverstion of the golas of cancer medicine: his drug has increased the prevalence of cancer in the world.)

Even targeted therapy, then, was a cat-and-mouse game. One could direct endless arrows at the Achilles' heel of cancer, but the disease might simply shift its foot, switching one vulnerability for another. We were locked in a perpetual battle with a volatile combatant. ... the Red Queen tells Alice that the world keeps shifting so quickly under her feet that she has to keep running just to keep her position. This is our predicament with cancer: we are forced to keep running merely to keep still.

today the idea of interrupting the dialogue between the tumor and its host environment underlies targeted therapy, immunotherapy, and nearly every active cancer research program. The company that developed Avastin was called Genentech. Between the day the company first announced the data and the day the FDA approved the drug, its market value increased by $38 billion, a rough measure of the value of the drug. (Folkman owned no stock in the company; he routinely donated any financial stakes and prize money he received to his hospital.) Later, Folkman would say, “You can tell a leader by counting the number of arrows in his ass.

CAR-T therapy in a very small subset of cancer patients with lymphoid disease is fantastically successful, albeit causing severe short-term toxicities and many known and unknown lifelong side effects. It is clear that much work lies ahead before this strategy can be scaled up for general use. Yet the hype surrounding CAR-T is such that practically every patient questions me about why they are being deprived of the magic cure. The results are not always magical: Despite high-target, cell-specific killing in vitro and encouraging preclinical efficacies in murine tumor models, clinical responses of adoptively transferred T cells expressing α-folate receptor (FR) specific CAR in ovarian cancer were disappointing. No reduction of tumor burden was seen in the 14 patients studied. The absence of efficacy was ascribed to lack of specific trafficking of the T cells to tumor and short persistence of the transferred T cells.

The narcissist will either stay cool, calm, and collected and act as though they have no idea as to why the target is so upset, or they will become more upset than the target and exclaim that they can’t handle the target’s insecurity, issues, hypersensitivity, craziness, delusional, bipolar, or toxic behavior, and declare that the target needs therapy or medication

You will invariably face jobs that are associated with uncomfortable feelings, ranging from relatively minor annoyance (e.g., taking out the garbage in the rain) to more persistent and recurring feelings of stress and discomfort (e.g., dissertation, organizing income taxes) that activate your procrastination script. Even a minimal degree of stress or inconvenience (what we have come to describe as the feeling of “Ugh”) can be potent enough to make you delay action. Think about some of the mundane examples of procrastination, such as watching a boring television show because the remote control is out of reach (e.g., “It’s ALL THE WAY over there.”) or exercise (e.g., “I’m TOO TIRED to change into my workout clothes.”). The use of capital letters is meant to illustrate the tone of voice of your selftalk, which serves to exaggerate and convince you of the difficulty of what you want to do. You are capable to perform the action, but your thoughts and feelings (including feeling tired or “low energy”) makes you conclude that you are not at your best and therefore cannot and will not follow through (for seemingly justifiable reasons). You might think, “I have to be in the mood to do some things.” But, how often are any of us in the mood to do many of the tasks on which we end up procrastinating? The very fact that we have to plan them indicates that these tasks require some targeted planning and effort. When facing emotional discomfort, ADHD adults are particularly at risk for bolting to pleasant, easy, and yet often unsatisfying activities, such as eating junk food, watching television, social networking, surfing the Internet, etc. In fact, sometimes you may escape from stressful tasks by performing other, lower priority errands or chores. Thus, you rationalize violating your high-priority project plan in order to run out to fill your car with gas. This strategy can be seen as a form of “plea bargaining”—“I will do something productive in order to justify not doing the higher priority but less appealing task.” Moreover, these errands are often more discrete and time limited than the task you are putting off (i.e., “If I start mowing the lawn now, I will be done in 1 hour. I don’t know how long taxes will take me.”), which is often their appeal—even though they are low priority, you are more confident you will get them done. You need not be “in the mood” for a task in order to perform it. A useful reframe is the reminder that you have “enough” energy to get started and recall that once you get started on the first step, you usually feel better and more engaged. Breaking the task down into its discrete steps and setting an end time help you to reframe the plan (e.g., “I’m tired, but I have enough energy to do this task for 15 minutes.”). Rather than setting up the unrealistic expectation that you must be stress-free and 100% energized before you can do tasks, the notion of acceptance of discomfort is a useful mindset to adopt and practice.

List your ten favorite comedians and humorists, and search for jokes, tweets, or quotes by each of these individuals. After you amass twenty jokes, identify the subject or target of the joke, and explain why you think the joke is funny. This exercise will help you become aware of the format of successful jokes and provide you with insight into your own comedic preferences. Collect ten to fifteen cartoons or comics. As you did with the jokes, identify the target of the humor and describe why the cartoon is funny to you. You may find it helpful to continue building a file of jokes and cartoons that appeal to you. In addition to building a joke and cartoon file, you’ll need to find new material to use as the building blocks for your humor writing. Most professional humor writers begin each day by reading a newspaper, watching news on TV, and/or surfing the Internet for incidents and situations that might provide joke material. As you read this book and complete the exercises at the end of each chapter, form a daily habit of recording odd and funny news events. Everyday life is the main source for humor, so you need to keep some type of personal humor journal. To facilitate psychoanalysis, Sigmund Freud had patients complete a dream diary, and he encouraged them to associate freely during therapy. To be a successful writer and to tap into the full potential of your comic persona, you should follow an analogous approach. Record everyday events, ideas, or observations that you find funny, and do your journaling without any form of censorship. The items you list are not intended to be funny, but to serve as starting points for writing humor.

Running held a prominent place in my mental health kit, as essential as medication and therapy.

In breaking with history, art has broken with all primitivism. Art may still seek plenitude and participation, therapies and ceremonies, a repeal of the dissociation of sensibility, but not routed through the past. Today the challenge to an obtuse and callous classicism is no longer mapped onto a rejection of tradition, nor does it ironically re-embrace traditions previously rejected. Now classicism, or intellectual vassalage, is internal to the present. The ancien régime targeted by modernism is no longer found in the past but rather embedded within our own society: mass culture, entertainment, the superstitions and stupidities, the half-hearted democracy, the disguised cruelty of the modern economy. It is just as in the era of religious conflict: content provides the resistance. Art is a struggle against false content. This struggle gives history its shape. Since the content of contemporary art is often topical, basically current events, there is a constant obligation to keep up the pace. This is consistent with the overall project of Enlightenment, whose successor is modernism. Within the project of emancipation, there is finally no tolerance for relativism. The Enlightenment was antirelativist; we saw that with Diderot, who did not allow historical perspective to deflect his present-tense opinions. Historicist relativism was allied instead with the neo-Christian reaction to Enlightenment. The Enlightenment critiques itself, of course, pointing out that the Enlightenment of the philosophes, or last year's enlightenment, was not enlightened enough. Ongoing self-castigation is the very shape of the Enlightenment project. However, anyone today who dares to revive the Romantic critique of the Enlightenment, namely, to take up again the illiberal call for remystification and recovery of trust in myth an ritual - anyone who dares to exit the Enlightenment - is vilified.

What she didn’t know was one of the worst things you can do is take a CN to therapy, especially in the beginning. Here is why: it’s like a training ground for them. When the counselor tells them what they are doing wrong, how they are hurting you, it shows them which part of their mask is cracking. They learn what you want, and what they need to do to impress you as well as others. They do what the therapist suggests, impressing the target and the therapist. Their heart isn’t in it, but they act like it is. The therapy sessions make you feel even more love and respect for them, once again sealing their image as the perfect mate, ensuring your love and loyalty for a very long time.

A metabolic, deep nutrition, and nontoxic approach is the answer to cancer prevention and management. This book is our call to arms—we must focus on the 90–95 percent of cancers that are caused by the standard American diet and exposure to environmental toxins. We simply cannot keep shrugging our shoulders when we, or our loved ones, are diagnosed. If a new virus began to kill one of every four people in the United States, you can bet your pink ribbon a cure would be found, and fast. While Western medicine continues to drive along the dusty, dead-end road seeking the genetic and targeted answer to cancer, it is time for us to start taking control of our own health and health care choices. We’ll say it again: Cancer is a metabolic, environmental, and emotional disease. It’s not just a tumor; it signifies correctable imbalances that occur inside and outside our body. Now is the time for lifelong remission. It is time for some real hope and to disarm the most deadly disease of modern times. How? With the metabolic approach to cancer.

Every multicellular organism begins as one cell, which contains all of the intricate instructions to synthesize, organize, and regulate not only this cell but the development and maintenance of all cells that will inevitably comprise the organism. All of these instructions are encoded in the first cell's DNA. This underscores the complexity of the genome and how each cell's expression must be controlled in specific ways depending on its function. The cells hailing from each tissue in the human body (e.g., muscle, lung, heart, liver) harbor a unique epigen­etic signature, which enables the maintenance of tissue-specific func­tions through the control of gene regulation, as just discussed. "Our knowledge of the total number of unique cells, or cell types, is still growing. Previous estimates put the number of unique cell types in the human body at ~300, but new estimates from the Human Cell Atlas have shown that we may have thousands of cell types and subtypes, each harboring a unique function for a specific physiological state or response to stimuli. But even cells of the same cell type will not be identical. A cell's 'presentation' of molecules on their surface can radi­cally change depending on internal variables such as genetic mutations or altered states of their epigenome, transcriptome, and proteome, as well as external stimuli including drugs and interactions with other cells. This novel presentation is most pronounced with a neoantigen, when a cancer cell creates an entirely new molecule on the surface of a cell. Given its unique presentation, which wouldn't be found in nor­mal cells, this offers a unique target for safer cancer therapies. "The human body has about 30 trillion human cells plus another 30-40 trillion bacterial cells, for a total of about 70 trillion cells. If your body were a democracy, the human cells would often be the minority or equal party. You (as a human) would never win an election. Your loss of control would likely result in you rolling around in the soil or lying in a bathtub full of yogurt, which I do sometimes on Sundays. Regard­less of how you spend your Sundays, there are a lot of microbes in, on, and around your body. There are in fact so many microbes that they compose the bulk of the cells on Earth. This is a humbling and exciting statistic, and one which is vividly apparent for anyone who has ever had explosive diarrhea.

Swedish massage is the most common form of massage therapy in the United States. This classic technique targets muscles in ways that promote relaxation and possible short-term pain relief.

DBT posits that borderline patients possess a genetic/biological vulnerability to emotional overreactivity. This view hypothesizes that the limbic system, the part of the brain most closely associated with emotional responses, is hyperactive in BPD. The second contributing factor, according to DBT practitioners, is an invalidating environment: that is, others dismiss, contradict, or reject the developing individual’s emotions. Confronted with such interactions, the individual is unable to trust others or her own reactions. Emotions are uncontrolled and volatile. To calm these erratic emotions, DBT emphasizes mindfulness, the process of paying attention to what is happening at the moment, without extreme emotional reactivity, judgment, or invalidation. In the initial stages of treatment, DBT focuses on a hierarchical system of targets, confronting first the most serious and then later the easier behaviors to change. The highest priority addressed immediately is the threat of suicide and self-injuring behaviors. The second-highest target is to eliminate behaviors that interfere with therapy, such as missed appointments or not completing homework assignments. The third priority is to address behaviors that interfere with a healthy quality of life, such as disruptive compulsions, promiscuity, or criminal conduct; among these, easier changes are targeted first. The fourth priority is to focus on increasing behavioral skills.

[T]he course of development most typical of our society is ... the transformation of a lively and promising human infant, through a period of indoctrination, disillusion and rebellion, into an emotionally constricted, competitively hostile adult saturated in the values of commodity consumption, desperately conforming, anxiously pursuing an ever-receding 'happiness', bereft of any ability to criticize the society in which he or she is located, pathetically eager to enjoy those of its 'fruits' (consumer durables) which are within reach. This is the great, inertially stable backbone of our society, the guardian of its values and the target of its mass media, working tirelessly in the interests of others and blindly against its own, forced by the crushing vice of economic power into reproducing itself reliably and endlessly in its children.

Lennon’s vituperative Rolling Stone interview was conducted in New York City in December 1970, shortly after the completion of his debut solo album John Lennon/Plastic Ono Band and his involvement with primal therapy. The album, Lennon’s masterpiece, showed the artist stripped bare: in turns paranoid, wounded and angry, railing against targets including fame, the Beatles, religion, drugs, his family and the media. In the interview he was similarly irascible, detailing the many grievances he felt at the disintegration of the Beatles and Apple, and reshaping the band’s historical narrative in the wake of the split. He later

Over the next couple of years, Cole and the rest of psychiatry settled on a trial design for testing psychotropic drugs. Psychiatrists and nurses would use “rating scales” to measure numerically the characteristic symptoms of the disease that was to be studied. Did a drug for schizophrenia reduce the patient’s “anxiety”? His or her “grandiosity”? “Hostility”? “Suspiciousness”? “Unusual thought content”? “Uncooperativeness”? The severity of all of those symptoms would be measured on a numerical scale and a total “symptom” score tabulated, and a drug would be deemed effective if it reduced the total score significantly more than a placebo did within a six-week period. At least in theory, psychiatry now had a way to conduct trials of psychiatric drugs that would produce an “objective” result. Yet the adoption of this assessment put psychiatry on a very particular path: The field would now see short-term reduction of symptoms as evidence of a drug’s efficacy. Much as a physician in internal medicine would prescribe an antibiotic for a bacterial infection, a psychiatrist would prescribe a pill that knocked down a “target symptom” of a “discrete disease.” The six-week “clinical trial” would prove that this was the right thing to do. However, this tool wouldn’t provide any insight into how patients were faring over the long term. Were they able to work? Were they enjoying life? Did they have friends? Were they getting married? None of those questions would be answered. This was the moment that magic-bullet medicine shaped psychiatry’s future. The use of the clinical trial would cause psychiatrists to see their therapies through a very particular prism, and even at the 1956 conference, New York State Psychiatric Institute researcher Joseph Zubin warned that when it came to evaluating a therapy for a psychiatric disorder, a six-week study induced a kind of scientific myopia. “It would be foolhardy to claim a definite advantage for a specified therapy without a two- to five-year follow-up,” he said. “A two-year follow-up would seem to be the very minimum for the long-term effects.

Hacking human biology Quantum mechanics has the ability to provide us with more knowledge about human biology beyond better disease detection and highly targeted, needle-free therapies. Australian scientists have recently discovered a way to investigate a living cell's inner workings using a new method of laser microscopy based on the concepts of quantum mechanics. And we can use quantum computers to sequence DNA quickly then solve other health-care challenges with Big Data. This opens the possibility of specialized treatment, based on the unique genetic structure of people.

numerous studies link gluten, the protein found in wheat, spelt, barley, rye and similar grains to Hashimoto’s.25 26 27 28 29 30 31 32 If the person is already on a gluten-free diet, I will have them consume wheat for two weeks and then repeat the test, providing gluten doesn’t cause other severe symptoms. A positive antibody test confirms an autoimmune thyroid condition and indicates that the immune system, not the thyroid gland, is the target for therapy.

Natural Ways to Help Depression Depression is not one illness. Like anxiety, the pandemic spawned a whole new level of people being diagnosed with depression and placed on antidepressant medication, without ever getting a proper evaluation or trying simple fixes. Here are nine common things I do for patients before prescribing antidepressant medication. 1. Check for and (if necessary) correct thyroid hormone abnormalities. 2. Work with a nutritionally informed physician to optimize your folate, vitamin B12, vitamin D, homocysteine, and omega-3 fatty acids. I’m convinced that without doing these nutritional fixes, patients are less likely to respond to the medications. 3. Try an elimination diet for three weeks. 4. Add colorful fruits and vegetables into your diet. 5. Eliminate the ANTs (automatic negative thoughts). See days 22, 116–117. 6. Exercise—walk like you are late for 45 minutes four times a week. This has been found to be as effective as antidepressant medication.[1] 7. Add one of the following supplements to your daily routine: Saffron 30 mg/day; curcumin, not as turmeric root but as Longvida, which is much more efficiently absorbed; zinc as citrate or glycinate 30 mg (tolerable upper level is 40 mg/day for adults, 34 mg/day for adolescents, less for younger kids); or magnesium glycinate, citrate, or malate, 100–500 mg with 30 mg of vitamin B6. 8. Consume probiotics daily. 9. Try morning bright light therapy with a therapeutic lamp of 10,000 lux for 20–30 minutes. If someone comes to me with depression, I order screening labs, teach them not to believe every negative thought they have, give them basic supplements (saffron, zinc, curcumins, and omega-3s), and encourage them to exercise. Many people never need medication if they follow through with the program. If the above interventions are ineffective, I’ll try other nutraceuticals or medications targeted to their specific type of depression (take the test at brainhealthassessment.com).

That fall, they moved in a greyhound named Target, a lapdog named Ginger, the four cats, and the birds. They threw out all their artificial plants and put live plants in every room. Staff members brought their kids to hang out after school; friends and family put in a garden at the back of the home and a playground for the kids. It was shock therapy.

The personal case histories were the most encouraging. A prominent Los Angeles public relations executive has been living with MM for fourteen years, rides horses, and has an altogether active life on drug maintenance. An Arizona man survived MM and with his wife set up a foundation and website for other families bewildered by the diagnosis. I learned, for the first time, that Frank McGee, host of the Today show from 1971 to 1974, suffered from MM and kept it from everyone despite his ever more gaunt appearance. When he died after putting in another full week on the air his producers and friends were stunned. Sam Walton, founder of Walmart, was another MM casualty, which led many to believe that he had established the high-profile multiple myeloma treatment center in Little Rock, Arkansas. This is a full-immersion process in which MM is the singular target under the commanding title of Myeloma Institute for Research and Therapy. There is a Walton auditorium on the institute’s University of Arkansas medical school campus, but the institute itself was founded by Bart Barlogie, a renowned MM specialist from the MD Anderson Cancer Center in Houston. The institute has an impressive record, running well ahead of the national average for survival for those who are dealing with MM. One number is especially notable. The institute has followed 1,070 patients for more than ten years, and 783 have never had a relapse of the disease. Sam Walton was treated by Dr. Barlogie at MD Anderson before the Little Rock institute was founded, but the connection ended there. Walton, who’d had an earlier struggle with leukemia, didn’t survive his encounter with multiple myeloma, dying in April 1992, a time when life expectancy for a man his age with this cancer was short. I was unaware of all of this when I was diagnosed. I took comfort in the repeated reassurances of specialists that great progress in treating MM with a new class of drugs, your own body’s reengineered immunology system, was rapidly improving chances of a longer survival than the published five to ten years. As I began to respond to treatment the favored and welcome line was, “You’re gonna die but from something else.

The success of the therapy relies on three main factors: the appropriate selection of patients, the accurate placement of the DBS lead in the sensorimotor regions of the target nuclei, and optimal choice of electrical parameters for stimulation.

A study of quadriplegics found that although most acknowledged having considered suicide at first, a year after having been paralyzed only 10 percent considered their lives to be miserable; most considered theirs to be good.6 Just as it is the mind that translates suffering into unhappiness, it is the mind’s responsibility to master its perception thereof. A change, even a tiny one, in the way we manage our thoughts and perceive and interpret the world can significantly change our existence. Changing the way we experience transitory emotions leads to a change in our moods and to a lasting transformation of our way of being. Such “therapy” targets the sufferings that afflict most of us and seeks to promote the optimal flourishing of the human being.

Cannabinoids are compounds that can activate two types of receptors within the ECS: CB1 receptors, which are located within the nervous system, brain, and nerve endings; and CB2 receptors, located primarily within the immune system. Targeting the ECS has been found to have anti-inflammatory, anticachexia, metabolic, pain management, antiseizure, and sleep-promoting effects.

In constraint-induced movement therapy, stroke patients wear a sling on their good arm for approximately 90 percent of waking hours for fourteen straight days. On ten of those days, they receive six hours of therapy, using their seemingly useless arm: they eat lunch, throw a ball, play dominoes or cards or Chinese checkers, write, push a broom, and use standard rehab equipment called dexterity boards. “It is fairly contrary to what is typically done with stroke patients,” says Taub, “which is to do some rehabilitation with the affected arm and then, after three or four months, train the unaffected arm to do the work of both arms.” Instead, for an intense six hours daily, the patient works closely with therapists to master basic but crucial movements with the affected arm. Sitting across a pegboard from the rehab specialist, for instance, the patient grasps a peg and labors to put it into a hole. It is excruciating to watch, the patient struggling with an arm that seems deaf to the brain’s commands to extend far enough to pick up the peg; to hold it tightly enough to keep it from falling back; to retract toward the target hole; and to aim precisely enough to get the peg in. The therapist offers encouragement at every step, tailoring the task to make it more attainable if a patient is failing, then more challenging once the patient makes progress. The reward for inserting a peg is, of course, doing it again—and again and again. If the patient cannot perform a movement at first, the therapist literally takes him by the hand, guiding the arm to the peg, to the hole—and always offering verbal kudos and encouragement for the slightest achievement. Taub explicitly told the patients, all of whose strokes were a year or more in the past, that they had the capacity for much greater use of their arm than they thought. He moved it for them and told them over and over that they would soon do the same. In just two weeks of constraint-induced movement therapy with training of the affected arm, Taub reported in 1993, patients regained significant use of a limb they thought would forever hang uselessly at their side. The patients outperformed control patients on such motor tasks as donning a sweater, unscrewing a jar cap, and picking up a bean on a spoon and lifting it to the mouth. The number of daily-living activities they could carry out one month after the start of therapy soared 97 percent. That was encouraging enough. Even more tantalizing was that these were patients who had long passed the period when the conventional rehab wisdom held that maximal recovery takes place. That, in fact, was why Taub chose to work with chronic stroke patients in the first place. According to the textbooks, whatever function a patient has regained one year after stroke is all he ever will: his range of motion will not improve for the rest of his life.

deeper issues (e.g. muscle, bone, brain, organs, glands, fat, etc.), we want around 10-40J per area, so optimal treatment times and distances with the lights I recommend are: 2-7 minutes per area (if the light is 6” inches away) 5-10 minutes per area (if the light is 12” away) I do not recommend going further away than 12” if you’re treating deeper tissues. Roughly 6” inches away is ideal for delivering the most light to the deeper tissues. If you get the Joovv light, these tend to have lower power density than the Red Rush360 and Platinum lights. So for the Joovv lights, you’ll want to add roughly 20-40% more time to the above dose ranges (when using them from 6-12” away from your body) E.g. If you would use the Red Rush360 for 10 minutes (from 12” away), you may need to use the Joovv Mini for 13-15 minutes to get the same dose. For use on the brain, some people recommend much relatively higher doses (the high end of my recommended dose ranges), due to the fact that it’s harder to deliver a significant amount of light to the brain tissues since the light has to penetrate through the skull before it can reach the brain. Thus, less overall light actually makes it to brain tissue (relative to say, treating fat or muscle tissue). As a general rule, the deeper the tissue and the more it is covered by bone, the longer doses will be needed to deliver a significant amount of light to that targeted tissue.

personally almost always use mine while laying down. I position the lights on the ground and lay next to them either on my side, back or front to treat the targeted area. I just find it more relaxing (than standing) to lay down while doing it.

Brain performance, mood enhancement (e.g. combatting depression and anxiety), or brain healing—Use the light (ideally a pure near-infrared light or 50-50 mix of NIR and red, since near-infrared penetrates the skull much more effectively than red light) from 6”-12” away. Since hair blocks the light, you want to use it on an area of your head without hair. For people with hair (no shaved or bald head), this generally means to use it on the forehead, or on the sides of the head through ear area, or at the base of the neck. The base of the neck may allow you to target the cerebrospinal fluid (the fluid that surrounds the brain), and this may provide beneficial effects on the cells in that fluid which impact brain health. The forehead is definitely the most effective area, and has actually been used in several of the studies on depression and brain enhancement. In addition to using the standard LED panels in this way, you also have the option to get the VieLight Neuro device, which allows you to work the lights into the base of your hair follicles and deliver light through the skull at multiple points on the head, even if you have hair. For people who wish to target the brain as their primary focus, I think it’s definitely worth it to get that VieLight Neuro device. (Note: I don’t recommend their intranasal lights—only the whole head “Neuro” device.)

Why is this? How can experience be so valuable in some professions but almost worthless in others? To see why, suppose that you are playing golf. You are out on the driving range, hitting balls toward a target. You are concentrating, and every time you fire the ball wide you adjust your technique in order to get it closer to where you want it to go. This is how practice happens in sport. It is a process of trial and error. But now suppose that instead of practicing in daylight, you practice at night—in the pitch-black. In these circumstances, you could practice for ten years or ten thousand years without improving at all. How could you progress if you don’t have a clue where the ball has landed? With each shot, it could have gone long, short, left, or right. Every shot has been swallowed by the night. You wouldn’t have any data to improve your accuracy. This metaphor solves the apparent mystery of expertise. Think about being a chess player. When you make a poor move, you are instantly punished by your opponent. Think of being a clinical nurse. When you make a mistaken diagnosis, you are rapidly alerted by the condition of the patient (and by later testing). The intuitions of nurses and chess players are constantly checked and challenged by their errors. They are forced to adapt, to improve, to restructure their judgments. This is a hallmark of what is called deliberate practice. For psychotherapists things are radically different. Their job is to improve the mental functioning of their patients. But how can they tell when their interventions are going wrong or, for that matter, right? Where is the feedback? Most psychotherapists gauge how their clients are responding to treatment not with objective data, but by observing them in clinic. But these data are highly unreliable. After all, patients might be inclined to exaggerate how well they are to please the therapist, a well-known issue in psychotherapy. But there is a deeper problem. Psychotherapists rarely track their clients after therapy has finished. This means that they do not get any feedback on the lasting impact of their interventions. They have no idea if their methods are working or failing—if the client’s long-term mental functioning is actually improving. And that is why the clinical judgments of many practitioners don’t improve over time. They are effectively playing golf in the dark.11

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What she didn't know was one of the worst things you can do is take a CN to therapy, especially in the beginning. Here is why: it's like a training ground for them. When the counselor tells them what they are doing wrong, how they are hurting you, it shoes them which part they need to do to impress you as well as others. They do what the therapist suggests, impressing the target and the therapist. Their heart isn't in it, but they act like it is.