Saturated Related Quotes

Marco opened the walkway gate just as a sprightly grey lizard skittered across the stone path. A bougainvillea vine laden with a riot of purple blooms scaled the right side of the house, and the heady scent of gardenias saturated the air.

That perhaps is your task--to find the relation between things that seem incompatible yet have a mysterious affinity, to absorb every experience that comes your way fearlessly and saturate it completely so that your poem is a whole, not a fragment; to re-think human life into poetry and so give us tragedy again and comedy by means of characters not spun out at length in the novelist's way, but condensed and synthesized in the poet's way--that is what we look to you to do now.

I am completely an elitist in the cultural but emphatically not the social sense. I prefer the good to the bad, the articulate to the mumbling, the aesthetically developed to the merely primitive, and full to partial consciousness. I love the spectacle of skill, whether it's an expert gardener at work or a good carpenter chopping dovetails. I don't think stupid or ill-read people are as good to be with as wise and fully literate ones. I would rather watch a great tennis player than a mediocre one, unless the latter is a friend or a relative. Consequently, most of the human race doesn't matter much to me, outside the normal and necessary frame of courtesy and the obligation to respect human rights. I see no reason to squirm around apologizing for this. I am, after all, a cultural critic, and my main job is to distinguish the good from the second-rate, pretentious, sentimental, and boring stuff that saturates culture today, more (perhaps) than it ever has. I hate populist [shit], no matter how much the demos love it.

reaches a cell wall, it disintegrates into hundreds of individual virus particles, and the broodlings push through the cell wall like hair and float away in the bloodstream of the host. The hatched Ebola particles cling to cells everywhere in the body, and get inside them, and continue to multiply. It keeps on multiplying until areas of tissue all through the body are filled with crystalloids, which hatch, and more Ebola particles drift into the bloodstream, and the amplification continues inexorably until a droplet of the host’s blood can contain a hundred million individual virus particles. After death, the cadaver suddenly deteriorates: the internal organs, having been dead or partially dead for days, have already begun to dissolve, and a sort of shock-related meltdown occurs. The corpse’s connective tissue, skin, and organs, already peppered with dead spots, heated by fever, and damaged by shock, begin to liquefy, and the fluids that leak from the cadaver are saturated with Ebola-virus

...we need other people to achieve individuality. For others to play this role for me, they have to be available to me in an unmediated way, not via a representation that is tailored to my psychic comfort. And conversely, I would have to make myself available to them in a way that puts myself at risk, not shying from a confrontation between different evaluative outlooks. For it is through such confrontations that we are pulled out of our own heads and forced to justify ourselves. In doing so, we may revise our take on things. The deepening of our understanding, and our affections, requires partners in triangulation: other people as other people, in relation to whom we may achieve an earned individuality of outlook. Absent such differentiation, there is a certain flattening of the human landscape. When [our shared spaces] are saturated with mass media, our attention is appropriated in such a way that the Public—an abstraction—comes to stand in for concrete others, and it becomes harder for us to show up for one another as individuals.

The saturated fats in dairy appear to be healthier than those in red meat.34 Shorter chain saturated fatty acids, such as the kind found in coconut, are metabolized quickly and don’t stick around long enough to cause much trouble. And to make matters even more complicated, the amount and type of carbohydrate in the diet influences how dietary fat affects blood lipids, with saturated fat and processed carbohydrate being an especially dangerous combination.35 So without bread, butter may be relatively benign.

There was another inspiring moment: a rough, choppy, moonlit night on the water, and the Dreadnaught's manager looked out the window suddenly to spy thousands of tiny baitfish breaking the surface, rushing frantically toward shore. He knew what that meant, as did everyone else in town with a boat, a gaff and a loaf of Wonder bread to use as bait: the stripers were running! Thousands of the highly prized, relatively expensive striped bass were, in a rare feeding frenzy, suddenly there for the taking. You had literally only to throw bread on the water, bash the tasty fish on the head with a gaff and then haul them in. They were taking them by the hundreds of pounds. Every restaurant in town was loading up on them, their parking lots, like ours, suddenly a Coleman-lit staging area for scaling, gutting and wrapping operations. The Dreadnaught lot, like every other lot in town, was suddenly filled with gore-covered cooks and dishwashers, laboring under flickering gaslamps and naked bulbs to clean, wrap and freeze the valuable white meat. We worked for hours with our knives, our hair sparkling with snowflake-like fish scales, scraping, tearing, filleting. At the end of the night's work, I took home a 35-pound monster, still twisted with rigor. My room-mates were smoking weed when I got back to our little place on the beach and, as often happens on such occasions, were hungry. We had only the bass, some butter and a lemon to work with, but we cooked that sucker up under the tiny home broiler and served it on aluminum foil, tearing at it with our fingers. It was a bright, moonlit sky now, a mean high tide was lapping at the edges of our house, and as the windows began to shake in their frames, a smell of white spindrift and salt saturated the air as we ate. It was the freshest piece of fish I'd ever eaten, and I don't know if it was due to the dramatic quality the weather was beginning to take on, but it hit me right in the brainpan, a meal that made me feel better about things, made me better for eating it, somehow even smarter, somehow . . . It was a protein rush to the cortex, a clean, three-ingredient ingredient high, eaten with the hands. Could anything be better than that?

But our Edenic tent–God doesn’t just want to save us. He actually wants to be with us. He doesn’t just love us. God actually likes us. So God removes His royal robes and steps down from His throne to experience—for the first time—what it is like to be human. God is omniscient, which means that He is all-knowing. There’s nothing in the universe, no piece of information, no fact, no statistic that He doesn’t know. The hairs on your head, the zits on your face—He knows about every one. But until the incarnation, God hadn’t experienced human nature. Since zits aren’t a sin, perhaps Jesus had them too. God knows every hair on your head, but through the incarnation, God knows what it feels like to have hair ripped out. God knows about tiredness, but through the incarnation, He experiences exhaustion. God knows how many molecules it takes to shoot a hunger pain from your stomach to your brain. But through the incarnation, God knows what it feels like to starve to the point of death. Through the incarnation, God has enjoyed the same warm wave of sunlight that splashes across your face on the first day of spring. When you bathe in it, God smiles because He’s bathed in it too. He’s been refreshed by a night’s sleep after a long day of work. Warmed by a toasty bed on a cold winter night. Enjoyed a rich glass of wine while celebrating among friends. God authored creation. But through the incarnation, God experienced creation. And He encountered joy under the bridge. He also experienced pain. Relational, psychological, emotional, and physical agony. God has suffered the misery and brokenness of the same sin-saturated world that oppresses us every day. The pain of being rejected, beaten, abused, unloved, uncared for, mocked, shamed, spat upon, and disrespected as an image bearer of the Creator. Jesus knows all of this. He’s experienced all of this. And He willingly endured it to bring you back to Eden.

Our brains, for instance, are 70 percent fat, mostly in the form of a substance known as myelin that insulates nerve cells and, for that matter, all nerve endings in the body. Fat is the primary component of all cell membranes. Changing the proportion of saturated to unsaturated fats in the diet, as proponents of Keys’s hypothesis recommended, might well change the composition of the fats in the cell membranes. This could alter the permeability of cell membranes, which determines how easily they transport, among other things, blood sugar, proteins, hormones, bacteria, viruses, and tumor-causing agents into and out of the cell. The relative saturation of these membrane fats could affect the aging of cells and the likelihood that blood cells will clot in vessels and cause heart attacks.

The relations of philosophy and theater are not commonly treated topics. When we think of theater we tend to light on two great periods, namely, Elizabethan England and ancient Athens. The latter we associate with philosophy, of course, but it is a very one-sided perception to think of the Greeks as philosophers. We should really think of them as a people of art – ein Reich der Kunst as Hölderlin calls Greece, and Hegel speaks of greek religion as a Kunstreligion, religion in the form of art. We do not think of Elizabethan England as a high period of philosophical reflection, and yet anyone who thinks Shakespeare’s work is not saturated with philosophical significance surely has a very narrow sense of what it means to be philosophical. His dramas are, so to say, philosophy in performatives.

Trying to earn God’s pleasure does not work. And yet it goes on all the time. All over the place. Look at any of the major monotheistic religions of the world. Tell us what you see. You see a system of thought where people perform certain acts or rites or scheduled ceremonies, hoping to keep their accounts paid up so they can one day turn them in for final redemption. Cashing in their chips. And it is so silly, these lists of things—especially when they become the way that saved-by-grace Christians try relating to God. This tilting-the-scales stuff is based on the very unbiblical idea that good little boys and girls are the ones who go to heaven. In reality, it’s bad little boys and girls transformed by the gospel of Jesus Christ who go to heaven—those whose sins are covered by His redeeming work, and who love Him so much because of it, they live now to flesh out these new desires He’s placed within them as a way of expressing their willing worship. Not to buy their way inside, but to celebrate being inside. Because we can never be redeemed by religion.

Equity financing, on the other hand, is unappealing to cooperators because it may mean relinquishing control to outside investors, which is a distinctly capitalist practice. Investors are not likely to buy non-voting shares; they will probably require representation on the board of directors because otherwise their money could potentially be expropriated. “For example, if the directors of the firm were workers, they might embezzle equity funds, refrain from paying dividends in order to raise wages, or dissipate resources on projects of dubious value.”105 In any case, the very idea of even partial outside ownership is contrary to the cooperative ethos. A general reason for traditional institutions’ reluctance to lend to cooperatives, and indeed for the rarity of cooperatives whether related to the difficulty of securing capital or not, is simply that a society’s history, culture, and ideologies might be hostile to the “co-op” idea. Needless to say, this is the case in most industrialized countries, especially the United States. The very notion of a workers’ cooperative might be viscerally unappealing and mysterious to bank officials, as it is to people of many walks of life. Stereotypes about inefficiency, unprofitability, inexperience, incompetence, and anti-capitalism might dispose officials to reject out of hand appeals for financial assistance from co-ops. Similarly, such cultural preconceptions may be an element in the widespread reluctance on the part of working people to try to start a cooperative. They simply have a “visceral aversion” to, and unfamiliarity with, the idea—which is also surely a function of the rarity of co-ops itself. Their rarity reinforces itself, in that it fosters a general ignorance of co-ops and the perception that they’re risky endeavors. Additionally, insofar as an anti-democratic passivity, a civic fragmentedness, a half-conscious sense of collective disempowerment, and a diffuse interpersonal alienation saturate society, this militates against initiating cooperative projects. It is simply taken for granted among many people that such things cannot be done. And they are assumed to require sophisticated entrepreneurial instincts. In most places, the cooperative idea is not even in the public consciousness; it has barely been heard of. Business propaganda has done its job well.106 But propaganda can be fought with propaganda. In fact, this is one of the most important things that activists can do, this elevation of cooperativism into the public consciousness. The more that people hear about it, know about it, learn of its successes and potentials, the more they’ll be open to it rather than instinctively thinking it’s “foreign,” “socialist,” “idealistic,” or “hippyish.” If successful cooperatives advertise their business form, that in itself performs a useful service for the movement. It cannot be overemphasized that the most important thing is to create a climate in which it is considered normal to try to form a co-op, in which that is seen as a perfectly legitimate and predictable option for a group of intelligent and capable unemployed workers. Lenders themselves will become less skeptical of the business form as it seeps into the culture’s consciousness.

And, even more important for our purposes, these facts are sturdy enough that we can build a sensible diet upon them. Here they are: FACT 1. Populations that eat a so-called Western diet—generally defined as a diet consisting of lots of processed foods and meat, lots of added fat and sugar, lots of refined grains, lots of everything except vegetables, fruits, and whole grains—invariably suffer from high rates of the so-called Western diseases: obesity, type 2 diabetes, cardiovascular disease, and cancer. Virtually all of the obesity and type 2 diabetes, 80 percent of the cardiovascular disease, and more than a third of all cancers can be linked to this diet. Four of the top ten killers in America are chronic diseases linked to this diet. The arguments in nutritional science are not about this well-established link; rather, they are all about identifying the culprit nutrient in the Western diet that might be responsible for chronic diseases. Is it the saturated fat or the refined carbohydrates or the lack of fiber or the transfats or omega-6 fatty acids—or what? The point is that, as eaters (if not as scientists), we know all we need to know to act: This diet, for whatever reason, is the problem. FACT 2. Populations eating a remarkably wide range of traditional diets generally don’t suffer from these chronic diseases. These diets run the gamut from ones very high in fat (the Inuit in Greenland subsist largely on seal blubber) to ones high in carbohydrate (Central American Indians subsist largely on maize and beans) to ones very high in protein (Masai tribesmen in Africa subsist chiefly on cattle blood, meat, and milk), to cite three rather extreme examples. But much the same holds true for more mixed traditional diets. What this suggests is that there is no single ideal human diet but that the human omnivore is exquisitely adapted to a wide range of different foods and a variety of different diets. Except, that is, for one: the relatively new (in evolutionary terms) Western diet that most of us now are eating. What an extraordinary achievement for a civilization: to have developed the one diet that reliably makes its people sick! (While it is true that we generally live longer than people used to, or than people in some traditional cultures do, most of our added years owe to gains in infant mortality and child health, not diet.) There is actually a third, very hopeful fact that flows from these two: People who get off the Western diet see dramatic improvements in their health. We have good research to suggest that the effects of the Western diet can be rolled back, and relatively quickly.

Going to therapy and talking about healing may just be the go-to flex of our time. It is supposedly an indicator of how profoundly self-aware, enlightened, emotionally mature, or “evolved” an individual is. Social media is obsessed and saturated with pop psychology and psychiatry content related to “healing”, trauma, embodiment, neurodiversity, psychiatric diagnoses, treatments alongside productivity hacks, self-care tips and advice on how to love yourself without depending on anyone else, cut people out of your life, manifest your goals to be successful, etc. Therapy isn’t a universal indicator of morality or enlightenment. Therapy isn’t a one-size-fits-all solution that everyone must pursue. There are many complex political and cultural reasons why some people don’t go to therapy, and some may actually have more sustainable support or care practices rooted in the community. This is similar to other messaging, like “You have to learn to love yourself first before someone else can love you”. It all feeds into the lie that we are alone and that happiness comes from total independence. Mainstream therapy blames you for your problems or blames other people, and often it oscillates between both extremes. If we point fingers at ourselves or each other, we are too distracted to notice the exploitative systems making us all sick and sad. Oftentimes, people come out of therapy feeling fully affirmed and unconditionally validated, and this ego-caressing can feel rewarding in the moment even if it doesn’t help ignite any growth or transformation. People are convinced that they can do no wrong, are infallible, incapable of causing harm, and that other people are the problem. Treatment then focuses on inflating self-confidence, self-worth, self-acceptance, and self-love to chase one’s self-centered dreams, ambitions, and aspirations without taking any accountability for one’s own actions. This sort of individualistic therapeutic approach encourages isolation and a general mistrust of others who are framed as threats to our inner peace or extractors of energy, and it further breeds a superiority complex. People are encouraged to see relationships as accessories and means to a greater selfish end. The focus is on what someone can do for you and not on how to give, care for, or show up for other people. People are not pushed to examine how oppressive conditioning under these systems shows up in their relationships because that level of introspection and growth is simply too invalidating. “You don’t owe anyone anything. No one is entitled to your time and energy. If anyone invalidates you and disturbs your peace, they are toxic; cut them out of your life. You don’t need that negativity. You don’t need anyone else; you alone are enough. Put yourself first. You are perfect just the way you are.” In reality, we all have work to do. We are all socialized within these systems, and real support requires accountability. Our liberation is contingent on us being aware of our bullshit, understanding the values of the empire that we may have internalized as our own, and working on changing these patterns. Therapized people may fixate on dissecting, healing, improving, and optimizing themselves in isolation, guided by a therapist, without necessarily practicing vulnerability and accountability in relationships, or they may simply chase validation while rejecting the discomfort that comes from accountability. Healing in any form requires growth and a willingness to practice in relationships; it is not solely validating or invalidating; it is complex; it is not a goal to achieve but a lifelong process that no one is above; it is both liberating and difficult; it is about acceptance and a willingness to change or transform into something new; and ultimately, it is going to require many invalidating ego deaths so we can let go of the fixation of the “self” to ease into interdependence and community care.

Today the challenge of political courage looms larger than ever before. For our everyday life is becoming so saturated with the tremendous power of mass communications that any unpopular or unorthodox course arouses a storm of protests such as John Quincy Adams—under attack in 1807—could never have envisioned. Our political life is becoming so expensive, so mechanized and so dominated by professional politicians and public relations men that the idealist who dreams of independent statesmanship is rudely awakened by the necessities of election and accomplishment. And our public life is becoming so increasingly centered upon that seemingly unending war to which we have given the curious epithet “cold” that we tend to encourage rigid ideological unity and orthodox patterns of thought. And thus, in the days ahead, only the very courageous will be able to take the hard and unpopular decisions necessary for our survival in the struggle with a powerful enemy—an enemy with leaders who need give little thought to the popularity of their course, who need pay little tribute to the public opinion they themselves manipulate, and who may force, without fear of retaliation

interconnectedness. The increasing interconnectedness of the world, whether it is driven by ‘Eros’ or by some altogether different human inclination, creates an abundance, even an overabundance, of relations and possibilities. The saturated space of possibilities, the hyperspace of possible options, exceeds the ‘facticity’ which would otherwise limit the ‘projection’, the freedom of choice, to speak with Heidegger, to ‘the possibility it has inherited’: ‘The resoluteness in which Dasein comes

In our fast-paced and entertainment-saturated world, men are still quick to ‘forget the Lord, … to do iniquity, and to be led away by the evil one’ ” (Alma 46:8). … “To stay safely on the priesthood path amid rock slides of temptation, I remind us of six fundamental principles that deepen conversion and strengthen family. “First, praying always opens the door for divine help to ‘conquer Satan’ (D&C 10:5). … “Second, studying ancient and modern scripture connects us to God. … “Third, worthily participating in ordinances prepares us to take ‘the Holy Spirit for [our] guide’ (D&C 45:57). … “Fourth, showing genuine love is at the heart of personal conversion and family relations. … “Fifth, obeying the law of tithing is an essential element of faith and family unity. … “Sixth, fully living the law of chastity yields confidence to stand ‘in the presence of God’ with the Holy Ghost as our ‘constant companion’ (D&C 121:45–46).

Respiratory Nursing   Chronic Obstructive Pulmonary Disease Diagnosis: Ineffective Breathing Pattern related to airflow restriction Desired Outcome: Following intervention, the patient's breathing pattern improves, as evidenced by absence of dyspnea and oxygen saturation >94%, pH >7.35, and PaCO2 <60 mm Hg. Assessments and Interventions Rationales Assess respiratory rate and depth q6h. Restlessness, dyspnea, tachypnea, use of accessory muscles of respiration are signs of respiratory distress, which should be reported. Auscultate breath sounds q6h. A decrease in breath sounds or an increase in wheezes is a sign of respiratory failure. Administer bronchodilator therapy with albuterol metered dose inhalers 2-4 puffs every 4 to 6 hours as needed. Albuterol increase expiratory volume by decreasing airway smooth muscle constriction. Administer ipratropium (Atrovent) 80 mcg, three times per day. Formoterol (Foradil) 12 mcg every 12 hours. Or administer tiotropium (Spiriva) 1 capsule (18 mcg) inhaled once daily by HandiHaler device Inhaled anticholinergics

I believe that what has been labeled as the politicization of entertainment —in fact, the politicization of storytelling— cannot be disassociated from the even more pressing issue of its low quality. Contemporary concerned writers are the equivalent of a technophilic movie director saturating his historical movies with all sort of modern technological marvels, arguing that modern audiences want to see things that reflect their own world and that the pre-industrial past was too dark and scary, so people need to see something relatable like modern technology or they may faint.

It also makes us question the admonitions that carbohydrate restriction cannot “generally be used safely,” as Theodore Van Itallie wrote in 1979, because it has “potential side effects,” including “weakness, apathy, fatigue, nausea, vomiting, dehydration, postural hypotension, and occasional exacerbation of preexisting gout.” The important clinical question is whether these are short-term effects of carbohydrate withdrawal, or chronic effects that might offset the benefits of weight loss. The same is true for the occasional elevation of cholesterol that will occur with fat loss—a condition known as transient hypercholesterolemia—and that is a consequence of the fact that we store cholesterol along with fat in our fat cells. When fatty acids are mobilized, the cholesterol is released as well, and thus serum levels of cholesterol can spike. The existing evidence suggests that this effect will vanish with successful weight loss, regardless of the saturated-fat content of the diet. Nonetheless, it’s often cited as another reason to avoid carbohydrate-restricted diets and to withdraw a patient immediately from the diet should such a thing be observed, under the mistaken impression that this is a chronic effect of a relatively fat-rich diet. In

Developed by E.M. Rogers in 1962, the S-curve model is an attempt to understand how, why, and at what rate ideas and products spread throughout cultures. Adoption is relatively slow at first, at the base of the S, until a tipping point, or knee of the curve, is reached. You then move into hypergrowth, up the sleek, steep back of the curve. This is usually at somewhere between 10 to 15 percent of market penetration. At the flat part at the top of the S, you've reached saturation, typically at 90 percent.

The body’s initial response to a noxious local insult is to produce a local inflammatory response with sequestration and activation of white blood cells and the release of a variety of mediators to deal with the primary ‘insult’ and prevent further damage either locally or in distant organs. Normally, a delicate balance is achieved between pro- and anti-inflammatory mediators. However, if the inflammatory response is excessive, local control is lost and a large array of mediators, including prostaglandins, leukotrienes, free oxygen radicals and particularly pro-inflammatory cytokines (p. 72), are released into the circulation. The inflammatory and coagulation cascades are intimately related. The process of blood clotting not only involves platelet activation and fibrin deposition but also causes activation of leucocytes and endothelial cells. Conversely, leucocyte activation induces tissue factor expression and initiates coagulation. Control of the coagulation cascade is achieved through the natural anticoagulants, antithrombin (AT III), activated protein C (APC) and tissue factor pathway inhibitor (TFPI), which not only regulate the initiation and amplification of the coagulation cascade but also inhibit the pro-inflammatory cytokines. Deficiency of AT III and APC (features of disseminated intravascular coagulation (DIC)) facilitates thrombin generation and promotes further endothelial cell dysfunction. Systemic inflammation During a severe inflammatory response, systemic release of cytokines and other mediators triggers widespread interaction between the coagulation pathways, platelets, endothelial cells and white blood cells, particularly the polymorphonuclear cells (PMNs). These ‘activated’ PMNs express adhesion factors (selectins), causing them initially to adhere to and roll along the endothelium, then to adhere firmly and migrate through the damaged and disrupted endothelium into the extravascular, interstitial space together with fluid and proteins, resulting in tissue oedema and inflammation. A vicious circle of endothelial injury, intravascular coagulation, microvascular occlusion, tissue damage and further release of inflammatory mediators ensues. All organs may become involved. This manifests in the lungs as the acute respiratory distress syndrome (ARDS) and in the kidneys as acute tubular necrosis (ATN), while widespread disruption of the coagulation system results in the clinical picture of DIC. The endothelium itself produces mediators that control blood vessel tone locally: endothelin 1, a potent vasoconstrictor, and prostacyclin and nitric oxide (NO, p. 82), which are systemic vasodilators. NO (which is also generated outside the endothelium) is implicated in both the myocardial depression and the profound vasodilatation of both arterioles and venules that causes the relative hypovolaemia and systemic hypotension found in septic/systemic inflammatory response syndrome (SIRS) shock. A major component of the tissue damage in septic/SIRS shock is the inability to take up and use oxygen at mitochondrial level, even if global oxygen delivery is supranormal. This effective bypassing of the tissues results in a reduced arteriovenous oxygen difference, a low oxygen extraction ratio, a raised plasma lactate and a paradoxically high mixed venous oxygen saturation (SvO2). Role of splanchnic ischaemia In shock, splanchnic hypoperfusion plays a major role in initiating and amplifying the inflammatory response, ultimately resulting in multiple organ failure (MOF). The processes involved include: • increased gut mucosal permeability • translocation of organisms from the gastrointestinal tract lumen into portal venous and lymphatic circulation • Kupffer cell activation with production and release of inflammatory mediators.

government had taken a hands-off approach to this ingredient: the NIH was instead focused on saturated fats and cholesterol, while the FDA never took much of an interest, perhaps because the ISEO made a point of keeping especially close relations with that agency: for decades, the fats-and-oils group even hired its presidents straight out of the FDA legal office.

The S curve is not just important as a model in its own right; it’s also the jack-of-all-trades of mathematics. If you zoom in on its midsection, it approximates a straight line. Many phenomena we think of as linear are in fact S curves, because nothing can grow without limit. Because of relativity, and contra Newton, acceleration does not increase linearly with force, but follows an S curve centered at zero. So does electric current as a function of voltage in the resistors found in electronic circuits, or in a light bulb (until the filament melts, which is itself another phase transition). If you zoom out from an S curve, it approximates a step function, with the output suddenly changing from zero to one at the threshold. So depending on the input voltages, the same curve represents the workings of a transistor in both digital computers and analog devices like amplifiers and radio tuners. The early part of an S curve is effectively an exponential, and near the saturation point it approximates exponential decay. When someone talks about exponential growth, ask yourself: How soon will it turn into an S curve? When will the population bomb peter out, Moore’s law lose steam, or the singularity fail to happen? Differentiate an S curve and you get a bell curve: slow, fast, slow becomes low, high, low. Add a succession of staggered upward and downward S curves, and you get something close to a sine wave. In fact, every function can be closely approximated by a sum of S curves: when the function goes up, you add an S curve; when it goes down, you subtract one. Children’s learning is not a steady improvement but an accumulation of S curves. So is technological change. Squint at the New York City skyline and you can see a sum of S curves unfolding across the horizon, each as sharp as a skyscraper’s corner. Most importantly for us, S curves lead to a new solution to the credit-assignment problem. If the universe is a symphony of phase transitions, let’s model it with one. That’s what the brain does: it tunes the system of phase transitions inside to the one outside. So let’s replace the perceptron’s step function with an S curve and see what happens.

Cohen testified that there was no 'direct relationship' linking heart disease to dietary fats, and that he had been able to induce the same blood-vessel complications seen in heart disease merely by feeding sugar to his laboratory rats. Peter Cleave testified to his belief that the problem extended to all refined carbohydrates. 'I don't hold the cholesterol view for a moment,' Cleave said, noting that mankind had been eating saturated fats for hundreds of thousands of years. 'For a modern disease to be related to an old-fashioned food is one of the most ludicrous things I have ever heard in my life... but, when it comes to the dreadful sweet things that are served up... that is a very different proposition.

SCIENTISTS HAD KNOWN since the late nineteenth century that tobacco smoke contains carbon monoxide. Victorian scientists had even been able to calculate the amount of gas in the smoke: up to 4 percent in cigarette smoke, and in Gettler’s own choice of tobacco, the cigar, between 6 and 8 percent. Gettler’s latest work theorized that chain smokers might suffer from low-level carbon monoxide poisoning. He speculated in a 1933 report that “headaches experienced by heavy smokers are due in part to the inhalation of carbon monoxide.” But his real interest lay less in their symptoms than in how much of the poison had accumulated in their blood, and how that might affect his calculations on cause of death. He approached that problem in his usual, single-minded way. To get a better sense of carbon monoxide contamination from smoking tobacco, Gettler selected three groups of people to compare: persons confined to a state institution in the relatively clean air of the country; street cleaners who worked in a daily, dusty cloud of car exhaust; and heavy smokers. As expected, carboxyhemoglobin blood levels for country dwellers averaged less than 1 percent saturation. The levels for Manhattan street cleaners were triple that amount, a solid 3 percent. But smokers came in the highest, higher than he’d expected, well above the nineteenth-century calculations. Americans were inhaling a lot more tobacco smoke than they had once done, and their saturation levels ranged from 8 to 19 percent. (The latter was from a Bronx cab driver who admitted to smoking six cigarettes on his way to Gettler’s laboratory, lighting one with the stub of another as he went.) It was safe to assume, Gettler wrote with his usual careful precision, that “tobacco smoking appreciably increases the carbon monoxide in the blood and cannot be ignored in the interpretation of laboratory results.”     THE OTHER NOTABLE poison in tobacco smoke was nicotine.

Posts that get the most Number of Repins have the following Features: They are related to trending topics and so have a ninety four percent more chance of being clicked on and then repinned. They have multiple colors and get repinned at a faster pace than pins with a single dominant color. Medium light pins get pinned twenty times more frequently than dark images. It is better to stay natural than pin too light or too dark images. Smooth texture images are repinned seventeen more times than those images that have a rough texture. Images with fifty percent color saturation receive ten percent more repins as compared to those that are de-saturated. Images with a less than ten percent background are able to get two to four more repins than images that have more than forty percent of white space. The winning combination is red, brown and orange. Blue is beaten by red so these images receive two times the number of repins that the blue ones receive. Images without faces receive twenty five percent more repins. On Pinterest, only twenty percent of the whole number of images features faces.

The impact of the internet on economic development is shifting in two important directions. First, given the aging population and near-saturated market penetration in the advanced economies, most of the expansion of the internet related market will take place in developing countries like Pakistan, India, and Bangladesh. Secondly, the globalization of the internet is expected to increase the share of developing countries in the internet economy presenting a historic opportunity for the young and poor in Pakistan to improve their economic condition.

Oil Is Not a Whole, Natural Food and Does Not Grow on Trees Although vegetable oils (such as olive, sesame, soybean, and canola oils) are relatively low in saturated fat and higher in unsaturated fats, you should use these processed foods minimally or not at all. Oils lack the beneficial factors that whole nuts and seeds contain. Nuts and seeds contain fiber, minerals, antioxidants, and other phytochemicals in addition to healthy fats that contribute to cardiovascular health.60 Most of these nutrients are missing in refined oils.

The dramatic strategy of the show provides a simple and effective means to blend melodrama with farce (which Sondheim claims as his “two favorite forms of theatre because … they are obverse sides of the same coin”).37 Starkly put, the show develops a pattern of first scaring the hell out of its audience and then rescuing the situation through humor, each time by introducing Mrs. Lovett into a situation saturated with Sweeney Todd’s wrenching angst. This scare-rescue pattern happens twice to great effect, at the beginning and end of Act I, but its real payoff is the devastating conclusion, where there is no comic rescue. The denial of this previous pattern greatly intensifies the darkness of the supremely bleak ending, making the show’s musical profile seem operatic to Broadway audiences even though, ironically in this respect, the denouement unfolds with only intermittent singing.38 But the musical dimension of the show is also deliberately operatic, as it interweaves, Wagner-like, a host of recurring motives, mostly related to each other through a common origin in the Dies Irae, from the Catholic requiem mass. The Dies Irae (literally, “Day of Wrath”; see example 7.1) was taken up as a symbol of death and retribution in music throughout the nineteenth century and continuing into the twentieth (the most important early such use was by Berlioz in his 1830 Symphonie fantastique). Most scene changes bring back “The Ballad of Sweeney Todd,” which includes both fast and slow versions of the Dies Irae (example 7.1) and builds up to a frenetic, obsessive chorus of “Sweeney, Sweeney.

Did saturated fat intake increase risk of heart disease? In a word, no. Here are the final conclusions of this forgotten jewel: ‘There is, in short, no suggestion of any relation between diet and the subsequent development of CHD [coronary heart disease] in the study group.

we have preliminary research findings from several NICUs that have implemented dim-lighting conditions during the day and near-blackout conditions at night. Under these conditions, infant sleep stability, time, and quality all improved. Consequentially, marked and significant improvements in neonate weight gain and significantly higher oxygen saturation levels in blood were observed, relative to those preterms who did not have their sleep prioritized and thus regularized. Better still, these well-slept preterm babies were also discharged from the hospital several weeks earlier!

For of course I am completely an elitist, in the cultural but emphatically not the social sense. I prefer the good to the bad, the articulate to the mumbling, the aesthetically developed to the merely primitive, and full to partial consciousness. I love the spectacle of skill, whether it’s an expert gardener at work, or a good carpenter chopping dovetails, or someone tying a Bimini hitch that won’t slip. I don’t think stupid or ill-read people are as good to be with as wise and fully literate ones. I would rather watch a great tennis player than a mediocre one, unless the latter is a friend or a relative. Consequently, most of the human race doesn’t matter much to me, outside the normal and necessary frame of courtesy and the obligation to respect human rights. I see no reason to squirm around apologizing for this. I am, after all, a cultural critic, and my main job is to distinguish the good from the second-rate, pretentious, sentimental, and boring stuff that saturates culture today, more (perhaps) than it ever has. I hate populist kitsch, no matter how much of the demos loves it. To me, it is a form of manufactured tyranny. Some Australians feel this is a confession of antidemocratic sin; but I am no democrat in the field of the arts, the only area—other than sports—in which human inequality can be displayed and celebrated without doing social harm. I have never looked down on spectator sports or on those who enjoy them—it’s just that, due perhaps to some deformity in my upbringing, I’ve never been particularly keen on watching them or felt concerned about which team, crew, or side won.

Unfortunately for the Inuit (and their Paleo imitators), the rest of the story isn’t so rosy. Turns out the Inuit are not healthy at all. They suffer from many chronic diseases and live, on average, ten years less than statistically matched Canadians (Choinière 1992; Iburg, Brønnum-Hansen, et al. 2001). In fact, they have the worst longevity of all populations in North America. There are many reasons for their short life expectancy: high rate of infections and TB, as well as a high suicide rate. While these may not be diet related (although more and more evidence suggests a strong connection between diet and the ability to fight of infection, and between diet and mood), Inuit also die of cancers of the GI tract and stroke, afflictions strongly correlated to diet (Paltoo and Chu 2004). Autopsy studies show they have less heart disease, likely due to their high omega-3 and low omega-6 and low-saturated-fat diet, but they are by no means free of heart disease (McLaughlin, Middaugh, et al. 2005). And there’s a possibility that autopsy statistics showing low heart disease are unreliable, based on really poor data collection (Bjerregaard, Young, et al. 2003; Bell, Mayer-Davis, et al. 1997). In fact, one of the likely reasons for their apparent low rates of heart disease and some cancers is their short life expectancy: Inuit eating their traditional diet simply don’t live long enough to demonstrate heart disease and cancer. In fact, the Westernization of their diet—adding the very foods the Paleo movement vilifies—may actually be prolonging their lives. A recent review of the literature suggests that a diet high in seafood does not lead to less heart disease and may lead to worse health (Fodor, Helis, et al. 2014)!

The following are guidelines for people at high risk of developing dementias (given family history or early cognitive decline): Adopt the Longevity Diet and the periodic FMD. Incorporate plenty of olive oil (50 milliliters per day) and nuts (30 grams per day). Drink coffee. For people at relatively low risk of AD, keep it to one or two cups a day; for people at high risk, drink up to three or four cups a day. Speak to your doctor if you have problems. Take 40 milliliters of coconut oil per day but consider potential heart disease risk (people with or at risk for cardiovascular disease should not use coconut oil). Avoid saturated fats and trans fats. Avoid all animal-based products with the exception of low-mercury fish and cheese or other dairy products from goat’s milk. Follow a high-nourishment diet containing omega-3, B vitamins, and vitamins C, D, and E. Take a multivitamin and mineral every day.

If you are not careful, your career and related obligations will saturate all of your time.

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Les riches aiment la compagnie des riches, c'est certain, disons qu'elle les apaise, il leur est doux de rencontrer des êtres soumis aux mêmes tourments, et qui semblent pouvoir entretenir avec eux une relation non totalement intéressée; il leur est doux de se persuader que l'espèce humaine n'est pas uniquement consitutuée de prédateurs et de parasites; à partit d'une certaine densité, quand mêmem, il y a de saturation.

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