Regulatory Related Quotes

Our analyses of the FDA data showed relatively little difference between the effects of antidepressants and the effects of placebos. Indeed, the effects were so small that they did not qualify as clinically significant. The drug companies knew how small the effect of their medications were compared to placebos, and so did the FDA and other regulatory agencies. The companies found various ways to make the data seem more favorable to their products, and the FDA helped them keep their negative data secret. In fact, in some instances, the FDA urged the companies to keep negative data hidden, even when the companies wanted to reveal them. My colleagues and I hadn't really discovered anything new. We had merely revealed their 'dirty little secret'.

Thus Marx begins his attack on the liberal concept of freedom. The freedom of the market is not freedom at all. It is a fetishistic illusion. Under capitalism, individuals surrender to the discipline of abstract forces (such as the hidden hand of the market made much of by Adam Smith) that effectively govern their relations and choices. I can make something beautiful and take it to market, but if I don’t manage to exchange it then it has no value. Furthermore, I won’t have enough money to buy commodities to live. Market forces, which none of us individually control, regulate us. And part of what Marx wants to do in Capital is talk about this regulatory power that occurs even “in the midst of the accidental and ever-fluctuating exchange relations between the products.” Supply and demand fluctuations generate price fluctuations around some norm but cannot explain why a pair of shoes on average trades for four shirts. Within all the confusions of the marketplace, “the labour-time socially necessary to produce [commodities] asserts itself as a regulative law of nature. In the same way, the law of gravity asserts itself when a person’s house collapses on top of him” (168). This parallel between gravity and value is interesting: both are relations and not things, and both have to be conceptualized as immaterial but objective.

... people with a secure attachment style view their partners' well-being as their responsibility. As long as they have reason to believe their partner is in some sort of trouble, they'll continue to back him or her. Mario Mikulincer and Phillip Shaver, in their book Attachment in Adulthood, show that people with a secure attachment style are more likely than others to forgive their partner for wrongdoing. They explain this as a complex combination of cognitive and emotional abilities: "Forgiveness requires difficult regulatory maneuvers . . . understanding a transgressor's needs and motives, and making generous attributions and appraisals concerning the transgressor's traits and hurtful actions . . . Secure people are likely to offer relatively benign explanations of their partners' hurtful actions and be inclined to forgive the partner." Also, as we've seen previously in this chapter, secure people just naturally dwell less on the negative and can turn off upsetting emotions without becoming defensively distant. The good news is that people with a secure attachment style have healthy instincts and usually catch on very early that someone is not cut out to be their partner. The bad news is that when secure people do, on occasion, enter into a negative relationship, they might not know when to call it quits--especially if it's a long-term, committed relationship in which they feel responsible for their partner's happiness.

In the comfortingly distorted view of the past, American slavery came about in the passive sense. That's just the way things were back then. Slavery was an inherited reality, a long-standing if unsavory fact of trade and war. In reality, colonial legislatures consciously conceived American chattel slavery at the turn of the eighteenth century, and they spelled out its terms in painstaking regulatory detail. Virginia's slave codes contained forty-one sections and more than four thousand words. ... The slave codes of 1705 are among American history's most striking evidence that our nation's greatest sins were achieved with clear forethought and determined maintenance.

Apple raised $17 billion in a bond offering in 2013. Not to invest in new products or business lines, but to pay a dividend to stockholders. The company is awash with cash, but much of that money is overseas, and there would be a tax charge if it were repatriated to the USA. For many other companies, the tax-favoured status of debt relative to equity encourages financial engineering. Most large multinational companies have corporate and financial structures of mind-blowing complexity. The mechanics of these arrangements, which are mainly directed at tax avoidance or regulatory arbitrage, are understood by only a handful of specialists. Much of the securities issuance undertaken by Goldman Sachs was not ‘helping companies to grow’ but represented financial engineering of the kind undertaken at Apple. What

THE NEW DEAL didn’t transform the Constitution only by institutionalizing nine unelected judges with lifetime tenure as a permanent constitutional convention, turning Woodrow Wilson’s theory into hard reality. It also allowed Congress to create, at the president’s request and with the blessing of the Court, an unprecedented regulatory state, made up of a constellation of administrative agencies—from the Federal Housing Administration and the Federal Communications Commission to the National Labor Relations Board and the Securities and Exchange Commission—that make rules, enforce them, and adjudicate transgressions of them.

Israeli authorities also maintain primary control over water resources in the West Bank and allocate water in a discriminatory fashion to Palestinians. [...] Military orders established in the first 18 months of the occupation in 1967 and 1968 granted the army full authority over water-related issues in the West Bank, declared water resources state property, and barred Palestinians from establishing or using water installations without a permit. In 1982, Israeli authorities transferred ownership of water resources and supply from the Civil Administration to the national Israeli water company, Mekorot, while continuing to vest the Civil Administration with regulatory control.

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We have a crisis in this nation, and it has nothing to do with regulatory reform or marginal tax rates. This book is not going to be about politics. (Sorry to disappoint.) It’s about something deeper and more meaningful. Something a little harder to quantify but a lot more personal. Despite the astonishing medical advances and technological leaps of recent years, average life span is in decline in America for the third year in a row. This is the first time our nation has had even a two-year drop in life expectancy since 1962—when the cause was an influenza epidemic. Normally, declines in life expectancy are due to something big like that—a war, or the return of a dormant disease. But what’s the “big thing” going on in America now? What’s killing all these people? The 2016 data point to three culprits: Alzheimer’s, suicides, and unintentional injuries—a category that includes drug and alcohol–related deaths. Two years ago, 63,632 people died of overdoses. That’s 11,000 more than the previous year, and it’s more than the number of Americans killed during the entire twenty-year Vietnam War. It’s almost twice the number killed in automobile accidents annually, which had been the leading American killer for decades. In 2016, there were 45,000 suicides, a thirty-year high—and the sobering climb shows no signs of abating: the percentage of young people hospitalized for suicidal thoughts and actions has doubled over the past decade.1 We’re killing ourselves, both on purpose and accidentally. These aren’t deaths from famine, or poverty, or war. We’re literally dying of despair.

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Goldman, or even systemically important, publicly traded banks. It has much broader implications for organizations generally. This sociological study opened my eyes to the organizational elements as they relate to a culture and the importance of understanding them as they relate to organizational, competitive, technological, and regulatory pressures. The organizational elements help form the culture, the incentives and behavior—they can help a firm be “long-term greedy.” In addition, organizational elements can help constrain or manage organizational drift.

The structure of regulatory relations created obstacles to social control, limiting information and knowledge about the O-ring problems. It inhibited the ability of safety regulators to alter the scientific paradigm on which the belief in acceptable risk was based.

includes such things as the current and prospective regulatory climate; the state of labor, supplier, and customer relations; the potential impact of changes in technology; competitive strengths and vulnerabilities; pricing power; scalability; environmental issues; and, notably, the presence of hidden exposures. (Charlie

Goodsit (1997), for example argued that patients with anorexia nervosa manifest a facade of pseudo- self-sufficiency when confronted with parents who are themselves self-absorbed, anxious, or otherwise unavailable. In this process, the maturation of the anorexic's self-object and self-regulatory capacities are unable to fully develop, leaving them painfully dependent upon others for their well-being. Bulimic patients, in contrast, are seen as more tension-ridden impulsive, and conflicted about whether to pursue their own lives or to remain available to a parent who utilizes them to maintain his or her own psychic equilibrium. In this context, symptoms - whether self-starvation, bingeing, and/or purging - emerge as last-ditch efforts at self-soothing and tension regulation. Over time, eating disorders become chronic conditions that provide patients with a compensatory identity and sense of self.

Uber had to get creative to unlock the hard side of their network, the drivers. Initially, Uber’s focus was on black car and limo services, which were licensed and relatively uncontroversial. However, a seismic shift occurred when rival app Sidecar innovated in recruiting unlicensed, normal people as drivers on their platform. This was the “peer-to-peer” model that created millions of new rideshare drivers, and was quickly copied and popularized by Lyft and then Uber. Jahan Khanna, cofounder/chief technology officer of Sidecar, spoke of its origin: It was obvious that letting anyone sign up to be a driver would be a big deal. With more drivers, rides would get cheaper and the wait times would get shorter. This came up in many brainstorms at Sidecar, but the question was always, what was the regulatory framework that allows this to operate? What were the prior examples that weren’t immediately shut down? After doing a ton of research, we came onto a model that had been active for years in San Francisco run by someone named Lynn Breedlove called Homobiles that answered our question.22 It’s a surprising fact, but the earliest version of the rideshare idea came not from an investor-backed startup, but rather from a nonprofit called Homobiles, run by a prominent member of the LGBTQ community in the Bay Area named Lynn Breedlove. The service was aimed at protecting and serving the LGBTQ community while providing them transportation—to conferences, bars and entertainment, and also to get health care—while emphasizing safety and community. Homobiles had built its own niche, and had figured out the basics: Breedlove had recruited, over time, 100 volunteer drivers, who would respond to text messages. Money would be exchanged, but in the form of donations, so that drivers could be compensated for their time. The company had operated for several years, starting in 2010—several years before Uber X—and provided the template for what would become a $100 billion+ gross revenue industry. Sidecar learned from Homobiles, implementing their offering nearly verbatim, albeit in digital form: donations based, where the rider and driver would sit together in the front, like a friend giving you a ride. With that, the rideshare market was kicked off.

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The 5C structure is generic—useful to product, marketing, and more—whereas the way we presented the sections in this chapter is very focused on product management. It’s good to know what the “C”s stand for because you’ll likely hear 5C mentioned. Plus if you need to do a situational analysis on your feet in a meeting or interview, it’s relatively easy to remember. Company: This refers to the company’s experience, technology, culture, goals, and more. It’s similar to the material we covered in the “Why Does the Company Exist?,” “How Do We Know If Our Product’s Good?,” and “What Else Has Been, Is Being, and Will Be Built?” sections. Customers: Who are the people buying this product? What are the market segments? How big are they? What are people’s goals with buying this product? How do they make buying decisions? Where do they buy this type or product? This is similar to what we covered in the “Customers and Personas” and “Use Cases” sections. Collaborators: Who are the external people who make the product possible, including distributors, suppliers, logistical operators, groundwork support personnel, and so on? Competitors: Who is competing for your customers’ money? This includes actual and potential competitors. You should look at how they position their product, the market size they address, their strengths and weaknesses, and more. Climate: These are the macro-environmental factors, like cultural, regulatory, or technological trends and innovations.

The second factor reinforcing work group decision making was structural secrecy: patterns of information, the organizational structure, and the structure of regulatory relations perpetuated the normalization of deviance.

Singapore was vulnerable to the kind of ethnic pulls evident in the 1960s. The problem with this strong regulatory emphasis, however, is that it has allowed Singaporeans to enjoy the fruits of inter-ethnic peace without having to work significantly hard for it. To use a fashionable economic term, most Singaporeans are free-riders when it comes to race relations. Children recite the Pledge every school day. But , in truth, no deep commitment to multi-racialism is required, either in thought or action. Singaporeans can leave such work to the government, which is empowered to deal with prblems under a host of laws and regulations. This, sadly, does not say much for the whole Singaporean enterprise. A society which ethnic conflict is engineered out of existence by physically dispersing minorities and curbing rights of speech and assembly, is nothing to shout about

Singapore was vulnerable to the kind of ethnic pulls evident in the 1960s. The problem with this strong regulatory emphasis, however, is that it has allowed Singaporeans to enjoy the fruits of inter-ethnic peace without having to work significantly hard for it. To use a fashionable economic term, most Singaporeans are free-riders when it comes to race relations. Children recite the Pledge every school day. But , in truth, no deep commitment to multi-racialism is required, either in thought or action. Singaporeans can leave such work to the government, which is empowered to deal with prblems under a host of laws and regulations. This, sadly, does not say much for the whole Singaporean enterprise. A society which ethnic conflict is engineered out of existence by physically dispersing minorities and curbing rights of speech and assembly, is nothing to shout about.

The high taxes and regulatory burdens they favor have the effect of protecting established businesses. To accumulate a fortune requires earning a high rate of profit and continually reinvesting most of it in the business. The greater the tax burden, the harder this process becomes. In the same way that small investments can turn into big gains when compounded over time, even relatively small tax burdens can amount to enormous losses, since they too get compounded over time: the million dollars taxed away from a company today doesn’t just cost it a million dollars, but all the income that million dollars would have generated had the business been free to reinvest it. Regulations, meanwhile, impose substantial compliance costs on a business—costs that an established business with a bull pen of attorneys can more easily meet, but which can stop upstarts in their tracks.

competition in the current system is too local, because it is centered on relatively small, self-contained local institutions catering to local needs. Services are both delivered locally and managed locally. The local bias in health care is a throwback to an earlier era when medical care was less complicated, and travel more difficult. It has been institutionalized by prevailing ownership and governance structures for provider institutions, regulatory and reimbursement practices, and a lack of local provider accountability for performance.

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people are not trustworthy, that when stressed he cannot really emotionally stay connected to them, and that he is unworthy of being loved. This way of seeing the world is typical of insecure attachments and these unconscious emotional biases will guide overt behavior, especially under relational stress. What is more, the infant of a misattuned mother will frequently be presented with an aggressive expression on his mother’s face, implying he is a threat, or with an expression of fear-terror, implying that he is the source of alarm. Images of his mother’s aggressive and/or fearful face, and the resultant chaotic alterations in her bodily state, are internalized, meaning they are imprinted in his developing right brain limbic circuits as an implicit memory, below levels of consciousness. Although out of awareness, they can plague him and his relationships for his entire life unless he finds a way to bring them into conscious awareness and work with them. Furthermore, when the caregiver is attuned in her early interactions, her more mature nervous system is regulating the infant’s neurochemistry and homeostasis. This, in turn, has a profound influence on the structural organization of the developing brain. Conversely emotional trauma will negatively impact the parts of the brain which are developing at the time of trauma. For example, if high levels of stress hormones are circulating in a pregnant mother, it up-regulates the fetus’ developing stress response – making the child, and future adult hypersensitive to stress. Relational trauma that occurs around the time of birth has a negative impact on both the developing micro-architecture of the amygdala itself, and the amygdala’s connection to the HPA axis, as well as to other parts of the limbic system. Thus high levels of early unrepaired interpersonal stress have a profoundly harmful effect on the ability to form social bonds, and on temperament. Suffering unrepaired and frequent emotional stress after about ten months interferes with the experience-dependent maturation of the highest level regulatory systems in the right orbifrontal cortex. This opens the door

•Amnesty further notes that, as part of the right to life and other human rights, the responsibility of nations to prevent gun violence requires: (1) restricting access to firearms, especially on the part of those at an elevated risk of misusing them; and (2) implementing violence reduction measures where misuse of firearms persists. The human rights group asserts that nations “should establish robust regulatory systems,” including licensing, registration, restriction of certain weapon types, safe storage, research, and policy development. Nationally, the US has done little or nothing in relation to any of these policies for more than twenty-five years, and, due to the influence of the gun lobby, has seen Congress suppress funding for research on gun violence since 1996. Amnesty notes that countries not only have obligations to protect the lives of individuals from state agents but from actual or foreseeable threats at the hands of private individuals as well. Violence is especially foreseeable in low-income neighborhoods with persistently high levels of violence, poor public services, and policing that may not comply with international standards.

Children requiring primary somatosensory interventions are likely are to display frequent sensory misperceptions, appetite, feeding, or metabolism problems, persistent somatic or visceral dysregulation, fine or gross motor movement or balance impairment, sleep problems, or endocrine issues. Such anomalies will be in excess of normal for the developmental age. The treatment protocol will emphasize somatosensory experiences, self-regulation, and movement interventions, all of which provide the appropriate nature and pattern of activation to help these lower networks change. Language, reasoning, logic, and understanding are de-emphasized in favor of core regulatory functions. The somatosensory activities must be carried out in a richly positive relational context (Core Element 3) as the activity itself is insufficient for positive developmental growth and neural organization. Sensory activities must be planned and scheduled at specific times each day for short periods of about 10 to 15 minutes. Pick activities the child will enjoy, as children will not repeat those that are unrewarding. The activity, environment, and method may need to modified periodically to keep them fresh, attractive, and fun. Never force the child into an activity if he or she is uncomfortable with it. Take baby steps if the child is uncomfortable. Find safe ways for the child to engage in and experience the activity.

Schools also tend to minimize powerful healing and resilience-building activities like sports, music, and art. These are often viewed as elective or enrichment activities, when in fact they can be the very bedrock of academic learning, thanks to their regulatory and relational elements. Patterned, repetitive, rhythmic activity makes the overactive and overly reactive core regulatory networks (see Figure 2) get back “in balance.” Music falls into this category—both playing and listening. All sports involve doses of it. Dance, too. And, of course, each of these activities also has very important relational elements. You learn when to pass the ball to your teammate; you learn how to move with your dance partner; you synchronize playing your violin with other members of the orchestra. Finally, there are cognitive elements to sports, music, and other arts; they engage, activate, and synchronize activity throughout the brain, from the bottom up and from the top down. These are whole-brain healthy activities. Now imagine thirty children, sitting in rows in a classroom, passively listening to the teacher

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But if ncRNAs are so important for cellular function, surely we would expect to find that sometimes diseases are caused by problems with them. Shouldn’t there be lots of examples where defects in production or expression of ncRNAs lead to clinical disorders, aside from the imprinting or X inactivation conditions? Well, yes and no. Because these ncRNAs are predominantly regulatory molecules, acting in networks that are rich in compensatory mechanisms, defects may only have relatively subtle impacts. The problem this creates experimentally is that most genetic screens are good at detecting the major phenotypes caused by mutations in proteins, but may not be so useful for more subtle effects.

The reasons why industrial-scale CHP has not been used more widely in the United States are all related to regulatory and institutional hurdles. It can be difficult to make the necessary coordination arrangements with a large building that will accept and use a generator’s waste heat. It also requires navigating many siting, land use, and other rules to put generators into or near heat users. Arrangements with utilities are also a frequent issue. Because cogenerators displace utility sales, utilities don’t have an economic incentive to help them get established—yet utilities have to connect up and monitor the cogenerator and provide backup service when the cogenerator trips off (some cogenerators are “off the grid,” in which case there is no backup, but most are not).

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However, without its essential attributes the concept of ‘God’ is empty on its own. Like any other concept, it contains some essential features for your mind — at least God is either merely the Creator, or also Regulator of everything in the Universe, including your brain, mind and behavior. On the surface, maybe there is no serious distinction between them, since the majority looks at the surface only, the interchange of their meanings causes little or no discomfort for the intellect. But at the bottom there is clear-cut distinction between them. God as only the creator is the first cause of the Universe, which in turn also affects your brain and mind states through deterministic relationships between everything, visible or invisible for you, in the Universe. But even God itself cannot break that determinism and regulatory. In that context God is passive rather than active super power, he is not omnipotent, he can neither damn nor forgive you. Therefore, there is no need to worship, to perform numerous rituals, sacrifice, struggle for God against God’s enemies and so on and so forth. There is no appearance of any phenomenon, only the deep content related to ’emotional-motivational’ sub-system of mind such as the ultimate purpose of life and after death. The concept of ‘God’ with the meaning of just creator is more philosophical, and in some context more ‘scientific’, than the concept of 'God' with also the meaning of the regulator. In the former meaning you can substitute the concept of ‘energy’, ‘information’, ‘hard determinism’ and so on, in their broader sense, for the concept of ‘God’. But you cannot do it related to the latter meaning, because unlike the former, it is ideological rather than philosophical and ‘scientific’. There is no free thought there, there is no free conceptual analysis there, your contemplation cannot circulate in any direction only on the base of the logical investigation and logical argumentation. it is going to be confined at some point after which would come all-powerful God’s will, expressed in the holy scriptures, and ideological interpretation of that will according to various political-economic interests. (The Denotation and Connotation of the concept of God, Part 3)

in 1932, coined the term “homeostasis” in his book The Wisdom of the Body.5 Cannon identified principles for an integrated system that tends to maintain relatively constant internal environments, including the idea that our regulatory systems are made of multiple components that are organized to work in concert to increase or decrease concentrations of critical nutrients and metabolic factors in the blood to achieve desirable levels. Such a constant environment enables our ability to migrate, run, hunt, work, or sleep independently of whether we happen to be eating, digesting, or fasting.

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