Pancreatic Cancer Quotes

One of us could always get pancreatic cancer,” you said pleasantly.

It was incredible, the way that people kept on going, whether they were dying of pancreatic cancer or drug addiction or the apocalypse itself.

I think I have found a set of biomarkers. Not from tissue biopsy—blood biomarkers. Noninvasive, easy to obtain. Cheap. In mice they can detect pancreatic cancer as early as stage one.

She remembered walking back from there last month, half-drunk with a gaggle of half-friends from her dorm, and when one of them asked her (only half-giving a shit) where she’d planned to go for Christmas break, Darby had answered bluntly: that it would require an act of God Himself to make her come back home to Utah. And apparently He’d been listening, because He’d blessed Darby’s mother with late-stage pancreatic cancer.

Mutations litter the chromosomes. In individual specimens of breast and colon cancer, between fifty to eighty genes are mutated; in pancreatic cancers, about fifty to sixty. Even brain cancers, which often develop at earlier ages and hence may be expected to accumulate fewer mutations, possess about forty to fifty mutated genes. Only a few cancers are notable exceptions to this rule, possessing relatively few mutations across the genome. One of these is an old culprit, acute lymphoblastic leukemia: only five or ten genetic alterations cross its otherwise pristine genomic landscape.* Indeed, the relative paucity of genetic aberrancy in this leukemia may be one reason that this tumor is so easily felled by cytotoxic chemotherapy. Scientists speculate that genetically simple tumors (i.e., those carrying few mutations) might inherently be more susceptible to drugs, and thus intrinsically more curable. If so, the strange discrepancy between the success of high-dose chemotherapy in curing leukemia and its failure to cure most other cancers has a deep biological explanation. The search for a “universal cure” for cancer was predicated on a tumor that, genetically speaking, is far from universal. In

[Ruth Bader] Ginsburg, the former women's rights advocate, made sure the nation knew she was there, even if alone. When President Obama addressed a joint session of Congress for the first time in February 2009, Ginsburg was recovering from pancreatic cancer and chemotherapy treatments, but she dragged herself to the evening event and sat with her brethren. She said she wanted to make sure that people watching the nationally televised address saw that the Supreme Court had at least one woman.

The Human Genome Project, the full sequence of the normal human genome, was completed in 2003. In its wake comes a far less publicized but vastly more complex project: fully sequencing the genomes of several human cancer cells. Once completed, this effort, called the Cancer Genome Atlas, will dwarf the Human Genome Project in its scope. The sequencing effort involves dozens of teams of researchers across the world. The initial list of cancers to be sequenced includes brain, lung, pancreatic, and ovarian cancer. The Human Genome Project will provide the normal genome, against which cancer’s abnormal genome can be juxtaposed and contrasted. The result, as Francis Collins, the leader of the Human Genome Project describes it, will be a “colossal atlas” of cancer—a compendium of every gene mutated in the most common forms of cancer: “When applied to the 50 most common types of cancer, this effort could ultimately prove to be the equivalent of more than 10,000 Human Genome Projects in terms of the sheer volume of DNA to be sequenced.

Did I develop my own set of random assumptions by utilizing the very little information available to me? For example, Leo Vodnik had held a magazine titled Construction Engineering Australia. Men are ten times more likely than women to die at work. Is that all it took for me to predict a “workplace accident” as his cause of death? Ethan Chang had his arm in a cast. Was it his injury that made me choose “assault,” together with the fact that injury and violence is a leading cause of death for young adult men? I know I watched Kayla Halfpenny at the airport and saw her knock over her drink and then her phone. Was it my observation of the sweet girl’s clumsiness together with the fact that road traffic injuries are one of the leading causes of death among young adults that led me to say “car accident”? Did I simply make random choices? Is that what led me to pancreatic cancer, the most feared cancer, for the vibrant woman who reminded me of my friend Jill, and breast cancer for the pregnant woman? Did I temporarily believe I was Madame Mae? I must have been thinking of my mother, because I kept saying “fate won’t be fought.” Had I somehow become a strange alchemy of the two of us? Both of us, after all, specialized in predictions.

For all malignant cancers, both fish eaters and vegetarians and vegans combined had significantly lower mortality than regular meat eaters [HR: 0.76 (95% CI: 0.63, 0.91) and HR: 0.82 (95% CI: 0.72, 0.94), respectively]. Vegetarians and vegans combined also had significantly lower mortality than did regular meat eaters for pancreatic cancer [HR: 0.47 (95% CI: 0.26, 0.86); P-heterogeneity = 0.065] and cancers of the lymphatic/hematopoietic tissue [HR: 0.43 (95% CI: 0.27, 0.70)], and low meat eaters had significantly lower respiratory disease mortality than regular meat eaters [HR: 0.69 (95% CI: 0.49, 0.97); P-heterogeneity = 0.14].

One of the four genes used by Yamanaka to reverse cellular fate is called c-myc. Myc, the rejuvenating factor, is no ordinary gene: it is one of the most forceful regulators of cell growth and metabolism known in biology. Activated abnormally, it can certainly coax an adult cell back into an embryo-like state, thereby enabling Yamanaka's cell-fate reversal experiment (this function requires the collaboration of the three other genes found by Yamanaka). But myc is also one of the most potent cancer-causing genes known in biology; it is also activated in leukemias and lymphomas, and in pancreatic, gastric, and uterine cancer. As in some ancient moral fable, the quest for eternal youthfulness appears to come at a terrifying collateral cost. The very genes that enable a cell to peel away mortality and age can also tip its fate toward malignant immortality, perpetual growth, and agelessness-the hallmarks of cancer.