Obesity Code Quotes

But diet and exercise are not fifty-fifty partners like macaroni and cheese. Diet is Batman and exercise is Robin. Diet does 95 per cent of the work and deserves all the attention; so, logically, it would be sensible to focus on diet. Exercise is still healthy and important—just not equally important. It has many benefits, but weight loss is not among them. Exercise is like brushing your teeth. It is good for you and should be done every day. Just don’t expect to lose weight.

Once we understand that obesity is a hormonal imbalance, we can begin to treat it. If we believe that excess calories cause obesity, then the treatment is to reduce calories. But this method has been a complete failure. However, if too much insulin causes obesity, then it becomes clear we need to lower insulin levels.

Coffee, even the decaffeinated version, appears to protect against type 2 diabetes. In a 2009 review, each additional daily cup of coffee lowered the risk of diabetes by 7 percent, even up to six cups per day.23

OBESITY IS NOT caused by an excess of calories, but instead by a body set weight that is too high because of a hormonal imbalance in the body.

BREAKFAST: THE MOST IMPORTANT MEAL TO SKIP?

The government is subsidizing, with our own tax dollars, the very foods that are making us obese. Obesity is effectively the result of government policy.

Let’s face the truth. Low-calorie diets have been tried again and again and again. They fail every single time.

A recent study suggests that 75 per cent of the weight-loss response in obesity is predicted by insulin levels.29 Not willpower. Not caloric intake. Not peer support or peer pressure. Not exercise. Just insulin.

THE LAST PIECE OF THE PUZZLE THERE ARE FIVE basic steps in weight loss: Reduce your consumption of added sugars. Reduced your consumption of refined grains. Moderate your protein intake. Increase your consumption of natural fats. Increase your consumption of fiber and vinegar.

Diet is Batman and exercise is Robin. Diet does 95 percent of the work and deserves all the attention; so, logically, it would be sensible to focus on diet. Exercise is still healthy and important—just not equally important. It has many benefits, but weight loss is not among them.

THERE ARE TWO prominent findings from all the dietary studies done over the years. First: all diets work. Second: all diets fail.

The healthy snack is one of the greatest weight-loss deceptions. The myth that ‘grazing is healthy’ has attained legendary status. If we were meant to ‘graze,’ we would be cows. Grazing is the direct opposite of virtually all food traditions. Even as recently as the 1960s, most people still ate just three meals per day. Constant stimulation of insulin eventually leads to insulin resistance. (For

In 1960, we ate three meals a day. There wasn’t much obesity. In 2014, we eat six meals a day. There is an obesity epidemic. So, do you really think we should eat six meals day? While

This is the ancient secret. This is the cycle of life. Fasting follows feasting. Feasting follows fasting. Diets must be intermittent, not steady. Food is a celebration of life. Every single culture in the world celebrates with large feasts. That’s normal, and it’s good. However, religion has always reminded us that we must balance our feasting with periods of fasting—“atonement,” “repentance” or “cleansing.” These ideas are ancient and time-tested. Should you eat lots of food on your birthday? Absolutely. Should you eat lots of food at a wedding? Absolutely. These are times to celebrate and indulge. But there is also a time to fast. We cannot change this cycle of life. We cannot feast all the time. We cannot fast all the time. It won’t work. It doesn’t work.

This is the ancient secret. This is the cycle of life. Fasting follows feasting. Feasting follows fasting. Diets must be intermittent, not steady. Food is a celebration of life. Every single culture in the world celebrates with large feasts. That’s normal, and it’s good. However, religion has always reminded us that we must balance our feasting with periods of fasting—“atonement,

Throughout most of human history, obesity has been rare. Individuals in traditional societies eating traditional diets seldom became obese, even in times of abundant food. As

There are an almost infinite number of ways that the body can dissipate excess energy instead of storing it as body fat.

IF YOU WANT to avoid weight gain, remove all added sugars from your diet. On

If you reduce your consumption of flour and refined grains, you will substantially improve your weight-loss potential. White

Obesity is a hormonal disorder of fat regulation. Insulin is the major hormone that drives weight gain, so the rational therapy is to lower insulin levels.

Metabolic syndrome, of which obesity and type 2 diabetes are a key part, are ultimately caused by—you guessed it—too much sugar.

All the conditions we thought were problems—obesity, insulin resistance, and beta cell dysfunction—are actually the body’s solutions to a single root cause—too much sugar.

Simplistic arguments that “Carbs make you fat!” or “Calories make you fat!” or “Red meat makes you fat!” or “Sugar makes you fat!” do not fully capture the complexity of human obesity. The

Refined carbohydrates are easy to become addicted to and overeat precisely because there are no natural satiety hormones for refined carbs. The reason, of course, is that refined carbohydrates are not natural foods but are highly processed. Their toxicity lies in that processing. p101

Unfortunately, we spend obsessive amounts of time and energy trying to understand what we should be eating and devote virtually no time to when we should be eating. We are only seeing half the picture.

Too often, our current model of obesity assumes that there is only one single true cause, and that all others are pretenders to the throne. Endless debates ensue. Too many calories cause obesity. No, too many carbohydrates. No, too much saturated fat. No, too much red meat. No, too much processed foods. No, too much high fat dairy. No, too much wheat. No, too much sugar. No, too much highly palatable foods. No, too much eating out. It goes on and on. They are all partially correct.

Paracelsus (1493–1541), the founder of toxicology and one of the three fathers of modern Western medicine (along with Hippocrates and Galen), wrote, ‘Fasting is the greatest remedy—the physician within.’ Benjamin Franklin (1706–90), one of America’s founding fathers and renowned for wide knowledge, once wrote of fasting, ‘The best of all medicines is resting and fasting.

In a modern twist to the classic overeating experiments, Feltham decided that he would eat 5794 calories per day and document his weight gain. But the diet he chose was not a random 5794 calories. He followed a low-carbohydrate, high-fat diet of natural foods for twenty-one days. Feltham believed, based on clinical experience, that refined carbohydrates, not total calories, caused weight gain. The macronutrient breakdown of his diet was 10 percent carbohydrate, 53 percent fat and 37 percent protein. Standard calorie calculations predicted a weight gain of about 16 pounds (7.3 kilograms). Actual weight gain, however, was only about 2.8 pounds (1.3 kilograms). Even more interesting, he dropped more than 1 inch (2.5 centimeters) from his waist measurement. He gained weight, but it was lean mass.

Fasting carries significant health benefits. Metabolism increases, energy increases and blood sugars decrease. The only remaining question is this: Can you do it? I hear this one all the time. Absolutely, 100 percent yes. In fact, fasting has been a part of human culture since the dawn of our species.

What would happen if the body continued to expend 3000 calories daily while taking in only 1500? Soon fat stores would be burned, then protein stores would be burned, and then you would die. Nice. The smart course of action for the body is to immediately reduce caloric expenditure to 1500 calories per day to restore balance. Caloric

There’s a simple answer to the question of what to eat at snack time. Nothing. Don’t eat snacks. Period. Simplify your life.

Therefore, the hormonal theory of obesity takes shape: chronically high cortisol raises insulin levels, which in turn leads to obesity.

Even the National Cholesterol Education Program admits, “The percentage of total fat in the diet, independent of caloric intake, has not been documented to be related to body weight.

HOPE FOR THE FUTURE TYPE 2 DIABETES is currently the leading cause of blindness, kidney failure, amputations, heart attacks, strokes, and cancer. But it doesn’t have to be our future. The pages of The Obesity Code and The Diabetes Code contain the knowledge to reverse type 2 diabetes. This is not the end, but only the beginning. A new hope arises. A new dawn breaks.

Doctors generally adhere to the Hippocratic oath, where they swear to abide by an ethical code, where they swear to act, always, in their patients’ best interests. Unless the patient is overweight. I hate going to the doctor because they seem wholly unwilling to follow the Hippocratic oath when it comes to treating obese patients. The words “first do no harm” do not apply to unruly bodies. There

Hormones are central to understanding obesity. Everything about human metabolism, including the body set weight, is hormonally regulated. A critical physiological variable such as body fatness is not left up to the vagaries of daily caloric intake and exercise. Instead, hormones precisely and tightly regulate body fat. We don't consciously control our body weight any more than we control our heart rates, our basal metabolic rates, our body temperatures or our breathing. These are all automatically regulated, and so is our weight. Hormones tell us when we are hungry (ghrelin). Hormones tell us we are full (peptide YY, cholecystokinin). Hormones increase energy expenditure (adrenalin). Hormones shut down energy expenditure (thyroid hormone). Obesity is a hormonal dysregulation of fat accumulation. Calories are nothing more than a proximate cause of obesity.

Instead, we believe that the fault lies in ourselves. We feel we have failed. Some silently criticize us for not adhering to the diet. Others silently think we have no willpower and offer us meaningless platitudes. Sound familiar? The failing isn’t ours. The portion-control caloric-reduction diet is virtually guaranteed to fail. Eating less does not result in lasting weight loss.

The Parable of the Cow”: Two cows were discussing the latest nutritional research, which had been done on lions. One cow says to the other, “Did you hear that we’ve been wrong these last 200 years? The latest research shows that eating grass is bad for you and eating meat is good.” So the two cows began eating meat. Shortly afterward, they got sick and they died. One year later, two lions were discussing the latest nutritional research, which was done on cows. One lion said to the other that the latest research showed that eating meat kills you and eating grass is good. So, the two lions started eating grass, and they died. What’s the moral of the story? We are not mice. We are not rats. We are not chimpanzees or spider monkeys. We are human beings, and therefore we should consider only human studies.

Type 2 diabetics drinking two tablespoons of apple cider vinegar diluted in water at bedtime reduced their fasting morning blood sugars.32 Higher doses of vinegar also seem to increase satiety, resulting in slightly lower caloric intake through the rest of the day (approximately 200 to 275 calories less). This effect was also noted for peanut products. Interestingly, peanuts also resulted in a reduction of glycemic response by 55 per cent.

Contrary to popular belief, sitting in front of the television or computer is a poor way to relieve stress. Instead, stress relief is an active process. There are many time-tested methods of stress relief, including mindfulness meditation, yoga, massage therapy and exercise. Studies on mindfulness intervention found that participants were able to use yoga, guided meditations and group discussion to successfully reduce cortisol and abdominal fat.

the toxicity in much Western food lies in the processing, rather than in the food itself. The carbohydrates in Western diets are heavily skewed toward refined grains, and are thus highly obesogenic. Eggplant, kale, spinach, carrots, broccoli, peas, Brussels sprouts, tomatoes, asparagus, bell peppers, zucchini, cauliflower, avocados, lettuce, beets, cucumbers, watercress, cabbage, among others, are all extremely healthy carbohydrate-containing foods.

THE RESULTS ARE very consistent. Drugs that raise insulin levels cause weight gain. Drugs that have no effect on insulin levels are weight neutral. Drugs that lower insulin levels cause weight loss. The effect on weight is independent of the effect on blood sugar. A recent study suggests that 75 per cent of the weight-loss response in obesity is predicted by insulin levels.29 Not willpower. Not caloric intake. Not peer support or peer pressure. Not exercise. Just insulin.

Functional magnetic resonance imaging studies show that areas of the brain controlling emotion and cognition light up in response to food stimuli. Areas of the prefrontal cortex involved with restraint show decreased activity. In other words, it is harder for people who have lost weight to resist food. 15 This has nothing whatsoever to do with a lack of willpower or any kind of moral failure. It’s a normal hormonal fact of life. We feel hungry, cold, tired and depressed. These are all real, measurable physical effects of calorie restriction.

The succession of financial bubbles, and the amassing of personal and public debt, Whybrow views as simply an expression of the lizard-brained way of life. A color-coded map of American personal indebtedness could be laid on top of the Centers for Disease Control’s color-coded map that illustrates the fantastic rise in rates of obesity across the United States since 1985 without disturbing the general pattern. The boom in trading activity in individual stock portfolios; the spread of legalized gambling; the rise of drug and alcohol addiction; it is all of a piece. Everywhere you turn you see Americans sacrifice their long-term interests for a short-term reward.

that drinking diet soda was associated with a 43 percent increase in risk of vascular events (strokes and heart attacks). The 2008 Atherosclerosis Risk in Communities Study (ARIC)10 found a 34 percent increased incidence of metabolic syndrome in diet soda users, which is consistent with data from the 2007 Framingham Heart Study,11 which showed a 50 percent higher incidence of metabolic syndrome. In 2014, Dr. Ankur Vyas from the University of Iowa Hospitals and Clinics 12 presented a study following 59,614 women over 8.7 years in the Women’s Health Initiative Observational Study. The study found a 30 percent increase risk of cardiovascular events (heart attacks and

So why are we unable to acknowledge the truth? Dr. Fung’s answer is simple: we doctors lie to ourselves. If type 2 diabetes is a curable disease but all our patients are getting worse on the treatments we prescribe, then we must be bad doctors. And since we did not study for so long at such great cost to become bad doctors, this failure cannot be our fault. Instead, we must believe we are doing the best for our patients, who must unfortunately be suffering from a chronically progressive and incurable disease. It is not a deliberate lie, Dr. Fung concludes, but one of cognitive dissonance—the inability to accept a blatant truth because accepting it would be too emotionally devastating.

So, if one were to restrict dietary fats, then one must increase dietary carbohydrates and vice versa. In the developed world, these carbohydrates all tend to be highly refined. Low Fat = High Carbohydrate This dilemma created significant cognitive dissonance. Refined carbohydrates could not simultaneously be both good (because they are low in fat) and bad (because they are fattening). The solution adopted by most nutrition experts was to suggest that carbohydrates were no longer fattening. Instead, calories were fattening. Without evidence or historical precedent, it was arbitrarily decided that excess calories caused weight gain, not specific foods. Fat, as the dietary villain, was now deemed fattening—a previously unknown concept. The Calories-In/Calories-Out model began to displace the prevailing “fattening carbohydrates” model.

Starting a little over a decade ago, Target began building a vast data warehouse that assigned every shopper an identification code—known internally as the “Guest ID number”—that kept tabs on how each person shopped. When a customer used a Target-issued credit card, handed over a frequent-buyer tag at the register, redeemed a coupon that was mailed to their house, filled out a survey, mailed in a refund, phoned the customer help line, opened an email from Target, visited Target.com, or purchased anything online, the company’s computers took note. A record of each purchase was linked to that shopper’s Guest ID number along with information on everything else they’d ever bought. Also linked to that Guest ID number was demographic information that Target collected or purchased from other firms, including the shopper’s age, whether they were married and had kids, which part of town they lived in, how long it took them to drive to the store, an estimate of how much money they earned, if they’d moved recently, which websites they visited, the credit cards they carried in their wallet, and their home and mobile phone numbers. Target can purchase data that indicates a shopper’s ethnicity, their job history, what magazines they read, if they have ever declared bankruptcy, the year they bought (or lost) their house, where they went to college or graduate school, and whether they prefer certain brands of coffee, toilet paper, cereal, or applesauce. There are data peddlers such as InfiniGraph that “listen” to shoppers’ online conversations on message boards and Internet forums, and track which products people mention favorably. A firm named Rapleaf sells information on shoppers’ political leanings, reading habits, charitable giving, the number of cars they own, and whether they prefer religious news or deals on cigarettes. Other companies analyze photos that consumers post online, cataloging if they are obese or skinny, short or tall, hairy or bald, and what kinds of products they might want to buy as a result.

Alan Turing was another cryptanalyst who did not live long enough to receive any public recognition. Instead of being acclaimed a hero, he was persecuted for his homosexuality. In 1952, while reporting a burglary to the police, he naively revealed that he was having a homosexual relationship. The police felt they had no option but to arrest and charge him with “Gross Indecency contrary to Section 11 of the Criminal Law Amendment Act 1885.” The newspapers reported the subsequent trial and conviction, and Turing was publicly humiliated. Turing’s secret had been exposed, and his sexuality was now public knowledge. The British Government withdrew his security clearance. He was forbidden to work on research projects relating to the development of the computer. He was forced to consult a psychiatrist and had to undergo hormone treatment, which made him impotent and obese. Over the next two years he became severely depressed, and on June 7, 1954, he went to his bedroom, carrying with him a jar of cyanide solution and an apple. Twenty years earlier he had chanted the rhyme of the Wicked Witch: “Dip the apple in the brew, Let the sleeping death seep through.” Now he was ready to obey her incantation. He dipped the apple in the cyanide and took several bites. At the age of just forty-two, one of the true geniuses of cryptanalysis committed suicide.

Sequences of base pairs, called genes, code for and produce gene products such as proteins. If just one of the base pairs is altered by mutation, say from ultraviolet damage, a virus, or cigarette smoke, the resulting protein will be aberrant, and usually faulty. Some of these mutations are not fatal and are actually kept by the cells and the population. These are called single nucleotide polymorphisms, or SNPs. If the incidence of the change is found in less than 1 percent of the population of humans, it is called a mutation; if more than 1 percent, it is typically called an SNP. There are about twenty million SNPs found in humans, and they account for many differences in the appearance and behavior of people, from curly hair to obesity to drug addiction. It is these SNPs where the hunt for genetic “causes” of traits and diseases has focused since the 1990s.

This was a remarkable break from tradition. For the first time, a government institution intruded into the kitchens of America. Mom used to tell us what we should and should not eat. But from now on, Big Brother would be telling us. And he said, “Eat less fat and more carbohydrates.

1.Feeding:

The second lie, according to Dr. Fung, is our belief that type 2 diabetes is a disease of abnormal blood glucose levels for which the only correct treatment is progressively increasing insulin dosages. He argues, instead, that type 2 diabetes is a disease of insulin resistance with excessive insulin secretion—in contrast to type 1 diabetes, a condition of true insulin lack. To treat both conditions the same way—by injecting insulin—makes no sense. Why treat a condition of insulin excess with yet more insulin, he asks? That is the equivalent of prescribing alcohol for the treatment of alcoholism.

Obesity is a hormonal disorder of fat regulation.

In 1991, Dr. Stunkard examined sets of fraternal and identical twins in both conditions of being reared apart and reared together.4 Comparison of their weights would determine the effect of the different environments. The results sent a shockwave through the obesity-research community. Approximately 70 percent of the variance in obesity is familial.

Since hormones control both Calories In and Calories Out, obesity is a hormonal, not a caloric, disorder.

These five assumptions—the key assumptions in the caloric reduction theory of weight loss—have all been proved false. All calories are not equally likely to cause weight gain. The entire caloric obsession was a fifty-year dead end.

Various hormonal levels, including ghrelin—a hormone that, essentially, makes us hungry—were analyzed. Weight loss significantly increased ghrelin levels in the study’s subjects, even after more than one year, compared to the subjects’ usual baseline. What does that mean? It means that the subjects felt hungrier and continued to feel so, right up to end of the study. The study also measured several satiety hormones, including peptide YY, amylin and cholecystokinin, all of which are released in response to proteins and fats in our diet and serve to make us feel full. This response, in turn, produces the desired effect of keeping us from overeating. More than a year after initial weight loss, the levels of all three satiety hormones were significantly lower than before. What does that mean? It means that the subjects felt less full. With increased hunger and decreased satiety, the desire to eat rises. Moreover, these hormonal changes occur almost immediately and persist almost indefinitely. People on a diet tend to feel hungrier, and that effect isn’t some kind of psychological voodoo, nor is it a loss of willpower. Increased hunger is a normal and expected hormonal response to weight loss.

Dr. Keys’s Minnesota Starvation Experiment first documented the effect of “semi-starvation neurosis.” People who lose weight dream about food. They obsess about food. All they can think about is food. Interest in all else diminishes. This behavior is not some strange affliction of the obese. In fact, it’s entirely hormonally driven and normal. The body, through hunger and satiety signaling, is compelling us to get more food. Losing weight triggers two important responses. First, total energy expenditure is immediately and indefinitely reduced in order to conserve the available energy. Second, hormonal hunger signaling is immediately and indefinitely amplified in an effort to acquire more food. Weight loss results in increased hunger and decreased metabolism. This evolutionary survival strategy has a single purpose: to make us regain the lost weight.

STEP 1: REDUCE YOUR CONSUMPTION OF ADDED SUGARS

STEP 2: REDUCE YOUR CONSUMPTION OF REFINED GRAINS

STEP 3: MODERATE YOUR PROTEIN CONSUMPTION

STEP 4: INCREASE YOUR CONSUMPTION OF NATURAL FATS

response

STEP 5: INCREASE YOUR CONSUMPTION OF PROTECTIVE FACTORS

THERE ARE FIVE basic steps in weight loss: 1. Reduce your consumption of added sugars. 2. Reduce your consumption of refined grains. 3. Moderate your protein intake. 4. Increase your consumption of natural fats. 5. Increase your consumption of fiber and vinegar.

But there are no essential carbohydrates and no essential sugars. Those are not required for survival.

In 1988, the American Heart Association decided that it would be a good idea to start accepting cash to put its Heart Check symbol on foods of otherwise dubious nutritional quality.

Under conditions of chronic stress, glucose levels remain high and there is no resolution to the stressor.

What to eat 2. When to eat In considering the first question, there are some simple guidelines to follow. Reduce intake of refined grains and sugars, moderate protein consumption and increase natural fats. Maximize protective factors such as fiber and vinegar. Choose only natural, unprocessed foods. In considering the second question, balance insulin-dominant periods with insulin-deficient periods: balance your feeding and fasting. Eating continuously is a recipe for weight gain. Intermittent fasting is a very effective way to deal with when to eat. In the end, the question is this: If you don’t eat, will you lose weight? Yes, of course. So there is no real doubt about its efficacy. It will work.

Our body is not a simple scale balancing Calories In and Calories Out. Rather, our body is a thermostat.

First: all diets work.

The common uniting theme is the hormonal imbalance of hyper-insulinemia.

The mind is willing, but the flesh is weak.

We are writing a final examination called Obesity 101. Diet accounts for 95 percent of the grade and exercise for only 5 percent. Yet we spend 50 percent of our time and energy studying exercise. It is no wonder that our current grade is F—for Fat.

Obesity is a hormonal dysregulation of fat mass. The body maintains a body set weight, much like a thermostat in a house. When the body set weight is set too high, obesity results. If our current weight is below our body set weight, our body, by stimulating hunger and/or decreasing metabolism, will try to gain weight to reach that body set weight. Thus, excessive eating and slowed metabolism are the result rather than the cause of obesity.

Seventy percent of your tendency to gain weight is determined by your parentage. Obesity is overwhelmingly inherited.

Full-fat dairy will have virtually no effect on your weight.

Coffee drinking is associated with a 10 percent to 15 percent reduction in total mortality.26 Large-scale studies27 found that most major causes of death, including heart disease were reduced. Coffee may guard against the neurologic diseases Alzheimer’s,28, 29 Parkinson’s disease,30, 31 liver cirrhosis32 and liver cancer.

expenditure,40 lower risk of various types of cancer.41

I could see beauty in a moral code that emphasized self-control, resistance to temptation, cultivation of one’s higher, nobler self, and negation of the self’s desires. I could see the dark side of this ethic too: once you allow visceral feelings of disgust to guide your conception of what God wants, then minorities who trigger even a hint of disgust in the majority (such as homosexuals or obese people) can be ostracized and treated cruelly. The ethic of divinity is sometimes incompatible with compassion, egalitarianism, and basic human rights.

CALORIES IN, Calories Out plan for weight loss assumes that we have conscious control over what we eat. But this belief ignores the extremely powerful effect of the body’s hormonal state. The defining characteristic of the human body is homeostasis, or adaptation to change. Our body deals with an ever-changing environment. In response, the body makes adjustments to minimize the effects of such changes and return to its original condition. And so it is, when the body starts to lose weight. There are two major adaptations to caloric reduction. The first change, as we have seen, is a dramatic reduction in total energy

The key assumption of the theory that reducing caloric intake leads to weight loss is false, since decreased caloric intake inevitably leads to decreased caloric expenditure.

Obesity is a hormonal dysregulation of fat accumulation.

The crucial point to understand, however, is not how insulin causes obesity, but that insulin does, in fact, cause obesity. Once we understand that obesity is a hormonal imbalance, we can begin to treat it.

Increased Calories In and decreased Calories Out (eating more and moving less) does not cause obesity, but is instead the result of obesity.

The question is not how to balance calories; the question is how to balance our hormones.

The important question is this: Do artificial sweeteners increase insulin levels? Sucralose13 raises insulin by 20 percent, despite the fact that it contains no calories and no sugar. This insulin-raising effect has also been shown for other artificial sweeteners, including the “natural” sweetener stevia. Despite having a minimal effect on blood sugars, both aspartame and stevia raised insulin levels higher even than table sugar.14 Artificial sweeteners that raise insulin should be expected to be harmful, not beneficial. Artificial sweeteners may decrease calories and sugar, but not insulin. Yet it is insulin that drives weight gain and diabetes.

Caloric intake and expenditure are intimately dependent variables. Decreasing Calories In triggers a decrease in Calories Out. A 30 per cent reduction in caloric intake results in a 30 per cent decrease in caloric expenditure. The end result is minimal weight loss.

Our bodies possess an intricate system guiding us to eat or not. Body-fat regulation is under automatic control, like breathing. We do not consciously remind ourselves to breathe, nor do we remind our hearts to beat. The only way to achieve such control is to have homeostatic mechanisms. Since hormones control both Calories In and Calories Out, obesity is a hormonal, not a caloric, disorder.

The key assumption of the theory that reducing caloric intake leads to weight loss is false, since decreased caloric intake inevitably leads to decreased caloric expenditure. This sequence has been proven time and again. We just keep hoping that this strategy will somehow, this time, work. It won’t. Face it. In our heart of hearts, we already know it to be true. Caloric reduction and portion-control strategies only make you tired and hungry. Worst of all... you regain all the weight you have lost. I know it. You know it.

Basal metabolic rate for a lightly active average male is roughly 2500 calories per day. Walking at a moderate pace (2 miles per hour) for forty-five minutes every day, would burn roughly 104 calories. In other words, that will not even consume 5 per cent of the total energy expenditure. The vast majority (95 per cent) of calories are used for basal metabolism.

factors, including •genetics, •gender (basal metabolic rate is generally higher in men), •age (basal metabolic rate generally drops with age), •weight (basal metabolic rate generally increases with muscle mass), •height (basal metabolic rate generally increases with height), •diet (overfeeding or underfeeding), •body temperature, •external temperature (heating or cooling the body) and •organ function.

Diet is Batman and exercise is Robin. Diet does 95 per cent of the work and deserves all the attention; so, logically, it would be sensible to focus on diet. Exercise is still healthy and important—just not equally important. It has many benefits, but weight loss is not among them.

Exercise is like brushing your teeth. It is good for you and should be done every day. Just don’t expect to lose weight.

First, caloric intake increases in response to exercise—we just eat more following a vigorous workout. (They don’t call it ‘working up an appetite’ for nothing.) A prospective cohort study of 538 students from the Harvard School of Public Health found that ‘although physical activity is thought of as an energy deficit activity, our estimates do not support this hypothesis.’15 For every extra hour of exercise, the kids ate an extra 292 calories. Caloric intake and expenditure are intimately related: increasing one will cause an increase in the other. This is the biological principle of homeostasis.

The fundamental biological principle at work here is homeostasis. There appears to be a ‘set point’ for body weight and fatness, as first proposed in 1984 by Keesey and Corbett.9 Homeostatic mechanisms defend this body set weight against changes, both up and down. If weight drops below body set weight, compensatory mechanisms activate to raise it. If weight goes above body set weight, compensatory mechanisms activate to lower it. The problem in obesity is that the set point is too high.

Insulin acts on the insulin receptor to bring glucose into the cell. Insulin is the key and fits snugly into the lock (the receptor). The door opens and glucose enters. All hormones work in roughly the same fashion.

Insulin is a key regulator of energy metabolism, and it is one of the fundamental hormones that promote fat accumulation and storage.

Without sufficient insulin, glucose builds up in the bloodstream. Type 1 diabetes results from the autoimmune destruction of the insulin-producing cells in the pancreas, which results in extremely low levels of insulin.