Neutral Mutation Quotes

in the Bhagavad Gita. One stanza reads: “Offering the inhaling breath into the exhaling breath and offering the exhaling breath into the inhaling breath, the yogi neutralizes both breaths; thus he releases prana from the heart and brings life force under his control.”2 The interpretation is: “The yogi arrests decay in the body by securing an additional supply of prana (life force) through quieting the action of the lungs and heart; he also arrests mutations of growth in the body by control of apana (eliminating current). Thus neutralizing decay and growth, the yogi learns life-force control.” Another Gita stanza states: “That meditation-expert (muni) becomes eternally free who, seeking the Supreme Goal, is able to withdraw from external phenomena by fixing his gaze within the mid-spot of the eyebrows and by neutralizing the even currents of prana and apana [that flow] within the nostrils and lungs; and to control his sensory mind and intellect; and to banish desire, fear, and anger.”3

Life managed without males for its first billion years, much of which was passed as single cells in a series of warm ponds. Then, in some ancient and neutral Eden, the fruit of the tree of sexual knowledge - a new mutation - persuaded members of a particular clone to fuse with cells from another, and then to divide. That ingenious idea is good news for the novel gene, as it doubles its rate of spread, but is a lot less so for those who receive it, who are obliged to copy the extra DNA. At once, two factions emerge, one keen to force itself upon the other. Thus sex was invented. Soon one contestant began to cheat. Large cells are expensive, but are better at dividing because they have more food reserves. Small cells are cheaper to make, but cannot afford to split. Their sole chance of success hence lies in fusion with a large cell. The first males had appeared on the scene.

Modeling the evolution of modularity became significantly easier after a kind of genetic variation was discovered by quantitative trait locus (QTL) mapping in the lab of James Cheverud at Washington University called 'relationship QTL' or r-QTL for short. An r-QTL is a genetic locus that affects the correlations between two quantitative traits (i.e. their variational relationship, and therefore, 'relationship' loci). Surprisingly, a large fraction of these so-mapped loci are also neutral with respect to the character mean. This means one can select on these 'neutral' r-QTLs without simultaneously changing the character mean in a certain way. It was easy to show that differential directional selection on a character could easily lead a decrease in genetic correlation between characters. Of course, it is not guaranteed that each and every population has the right kind of r-QTL polymorphisms, nor is it yet clear what kind of genetic architecture allows for the existence of an r-QTL. Nevertheless, these findings make it plausible that differential directional selection can enhance the genetic/variational individuality of traits and, thus, may play a role in the origin of evolutionary novelties by selecting for variational individuality. It must be added, though, that there has been relatively little research in this area and that we will need to see more to determine whether we understand what is going on here, if anything. In particular, one difficulty is the mathematical modeling of gene interaction (epistasis), because the details of an epistasis model determine the outcome of the evolution by natural selection. One result shows that natural selection increases or decreases mutational variance, depending on whether the average epistatic effects are positive or negative. This means that the genetic architecture is more determined by the genetic architecture that we start with than by the nature of the selection forces that act upon it. In other words, the evolution of a genetic architecture could be arbitrary with respect to selection.

To their surprise, they found that dopamine actively regulates both the formation and the forgetting of new memories. In the process of creating new memories, the dCA1 receptor was activated. By contrast, forgetting was initiated by the activation of the DAMB receptor. Previously, it was thought that forgetting might be simply the degradation of memories with time, which happens passively by itself. This new study shows that forgetting is an active process, requiring intervention by dopamine. To prove their point, they showed that by interfering with the action of the dCA1 and DAMB receptors, they could, at will, increase or decrease the ability of fruit flies to remember and forget. A mutation in the dCA1 receptor, for example, impaired the ability of the fruit flies to remember. A mutation in the DAMB receptor decreased their ability to forget. The researchers speculate that this effect, in turn, may be partially responsible for savants’ skills. Perhaps there is a deficiency in their ability to forget. One of the graduate students involved in the study, Jacob Berry, says, “Savants have a high capacity for memory. But maybe it isn’t memory that gives them this capacity; maybe they have a bad forgetting mechanism. This might also be the strategy for developing drugs to promote cognition and memory—what about drugs that inhibit forgetting as a cognitive enhancers?” Assuming that this result holds up in human experiments as well, it could encourage scientists to develop new drugs and neurotransmitters that are able to dampen the forgetting process. One might thus be able to selectively turn on photographic memories when needed by neutralizing the forgetting process. In this way, we wouldn’t have the continuous overflow of extraneous, useless information, which hinders the thinking of people with savant syndrome. What is also exciting is the possibility that the BRAIN project, which is being championed by the Obama administration, might be able to identify the specific pathways involved with acquired savant syndrome. Transcranial magnetic fields are still too crude to pin down the handful of neurons that may be involved. But using nanoprobes and the latest in scanning technologies, the BRAIN project might be able to isolate the precise neural pathways that make possible photographic memory and incredible computational, artistic, and musical skills. Billions of research dollars will be channeled into identifying the specific neural pathways involved with mental disease and other afflictions of the brain, and the secret of savant skills may be revealed in the process. Then it might be possible to take normal individuals and make savants out of them. This has happened many times in the past because of random accidents. In the future, this may become a precise medical process.

We need to make a brief foray into one aspect of the history of molecular biology to unravel the paradox. In 1968, the Japanese geneticist Motoo Kimura proposed the “neutral theory” of molecular evolution.8 Kimura contended that most changes at the level of DNA and amino acids do not impact the function of a molecule and hence the organism’s ability to survive and reproduce. He contended that a small number of mutations are favorable, and natural selection preserves them. Some mutations are rejected because they are harmful, but most mutations don’t really affect the organism. According to Kimura, most mutations are neutral, which causes robustness in the organism. So how does neutral mutation lead to evolution? While a neutral change does not alter the primary function, it can alter a secondary function, thereby becoming the source of a future innovation

What causes people to get fat? Your body’s cells need three things to thrive and survive: 1) oxygen, 2) the proper nutrients and 3) The ability to eliminate waste. If any one of the three is lacking, your cells will mutate (into cancer cells, for example) in order to try to adapt and stay alive in the overly acidic environment. Normally when your body returns to an alkaline state, the mutated cells will devolve back into healthy red blood cells. This process is called pleomorphism. When your body does not have the energy or nutrients it needs to neutralize the acid, it cannot safely move these toxins and acids out of the body. So its only choice is to park them away from the

The paradigm of self-interest is neutral between a person’s decision to help others or to not help others. If fear and uncertainty make people more short-sighted, self-centric and engage in hoarding cash, withdrawing from banks, disinvesting their savings in capital markets and buying essential goods in bulk, then there is no drive, urge or impetus that economics can offer to suggest otherwise. It is neutral between these choices and the choice for altruism. On the other hand, as per physics, we were stardust before and stardust after extinction. As per evolutionary biology, we are one of the millions and millions of species that have earned the right to survive under the sun for a brief period until genetic mutations bury our specie as well. We were born through a fierce and destructive competition and survive until we manage to withstand that competition. While waiting and acting on morals, we should not be here in the first place.