Neurotransmitter Quotes

Consciousness is not just interaction of neurotransmitters in the brain it has also some quantum cosmic component.

A neuron didn’t know whether it fired in response to a scent or a symphony. Brain cells weren’t intelligent; only brains were. And brain cells weren’t even the lower limit. The origins of thought were buried so deep they predated multicellular life itself: neurotransmitters in choanoflagellates, potassium ion gates in Monosiga. I am a colony of microbes talking to itself, Brüks reflected.

Research to date has shown that, like many other stressors, grief frequently leads to changes in the endocrine, immune, autonomic nervous, and cardiovascular systems; all of these are fundamentally influenced by brain function and neurotransmitters.

Who could ever reckon up the damage done to love and friendship and all hopes of happiness by a surfeit or depletion of this or that neurotransmitter? And who will ever find a morality, an ethics down among the enzymes and amino acids when the general taste is for looking in the other direction?

Carol, I can’t describe how you make me feel. Wait, no, I can—you make my mind release pleasure-inducing neurotransmitters and you’ve flooded my mind with dopamine. If the experience of snorting cocaine and getting so high out of my mind that I want to climb a telephone pole with my bare hands just to see if I can do it were a person, it would be you.

90 percent of the serotonin in our bodies—the neurotransmitter that when abundant makes us feel happy, and when depleted makes us feel depressed—is produced in our guts, and gut microbes play a major role in regulating its production (Yano et al. 2015).

Hormones and neurotransmitters, the chemicals associated with human desire, fear, love, joy, and sadness, “are highly conserved across taxa,” Jennifer said. This means that whether you’re a person or a monkey, a bird or a turtle, an octopus or a clam, the physiological changes that accompany our deepest-felt emotions appear to be the same. Even a brainless scallop’s little heart beats faster when the mollusk is approached by a predator, just like yours or mine would do were we to be accosted by a mugger.

Addiction to alcohol is also a neurological phenomenon, the result of a complex set of molecular alterations that take place in the brain when it’s excessively and repeatedly exposed to the drug. The science of addiction is complicated, but the basic idea is fairly straightforward: alcohol appears to wreak havoc on the brain’s natural systems of craving and reward, compromising the functioning of the various neurotransmitters and proteins that create feelings of well-being.

To draw for a moment from an entirely different corner of my life, that part of me still attached to the biological sciences, there is ample evidence that animals — rats and monkeys, for example — that are forced into a subordinate status within their social systems adapt their brain chemistry accordingly, becoming 'depressed' in humanlike ways. Their behavior is anxious and withdrawn; the level of serotonin (the neurotransmitter boosted by some antidepressants) declines in their brains. And — what is especially relevant here — they avoid fighting even in self-defense ... My guess is that the indignities imposed on so many low-wage workers — the drug tests, the constant surveillance, being 'reamed out' by managers — are part of what keeps wages low. If you're made to feel unworthy enough, you may come to think that what you're paid is what you are actually worth.

Dopamine isn’t the pleasure molecule, after all. It’s the anticipation molecule. To enjoy the things we have, as opposed to the things that are only possible, our brains must transition from future-oriented dopamine to present-oriented chemicals, a collection of neurotransmitters we call the Here and Now molecules, or the H&Ns. Most people have heard of the H&Ns. They include serotonin, oxytocin, endorphins (your brain’s version of morphine), and a class of chemicals called endocannabinoids (your brain’s version of marijuana). As opposed to the pleasure of anticipation via dopamine, these chemicals give us pleasure from sensation and emotion. In fact, one of the endocannabinoid molecules is called anandamide, named after a Sanskrit word that means joy, bliss, and delight.

Love? What is it? The most natural painkiller what there is.” You may become curious, though, about what happened to that painkiller should depression take hold and expose your love—whatever its object—as just one of the many intoxicants that muddled your consciousness of the human tragedy. You may also want to take a second look at whatever struck you as a person, place, or thing of “beauty,” a quality that lives only in the neurotransmitters of the beholder. (Aesthetics? What is it? A matter for those not depressed enough to care nothing about anything, that is, those who determine almost everything that is supposed to matter to us. Protest as you like, neither art nor an aesthetic view of life are distractions granted to everyone.) In depression, all that once seemed beautiful, or even startling and dreadful, is nothing to you. The image of a cloud-crossed moon is not in itself a purveyor of anything mysterious or mystical; it is only an ensemble of objects represented to us by our optical apparatus and perhaps processed as a memory.

By the time the last of these relationships ended I was such a quaking mass of colliding, exploding neurotransmitter malfunctions that the only coherent sentence I could form in my native tongue went: "Never again.

I could still feel the glare of his eyes, and the image of them was seared so firmly into my brain that it seemed like my neurotransmitters had gone and printed propaganda posters of him to hang up around the place. Washington, Jane (2015-09-14). Charcoal Tears (Seraph Black Book 1) (Kindle Locations 130-132). . Kindle Edition.

Exercise increases many of the neurotransmitters involved in positive mood regulation: dopamine, serotonin, norepinephrine, epinephrine, endocannabinoids, and endogenous opioid peptides (endorphins). Exercise contributes to the birth of new neurons and supporting glial cells. Exercise even reduces the likelihood of using and getting addicted to drugs.

...sometime in the late 1980s the neurotic was replaced, as a cultural type, by the depressive, who understands his unhappiness not in terms of conflict but rather in terms of mood. Mood is taken to be a function of neurotransmitters, about which there’s not much to say. Inarticulacy is baked into any description of the human being that we express in neuro-talk.

In class I had been taught about neurotransmitters and their effect on brain chemistry; I understood that disease is not a choice. This knowledge might have made me sympathetic to my father, but it didn’t. I felt only anger. We were the ones who’d paid for it, I thought. Mother. Luke. Shawn. We had been bruised and gashed and concussed, had our legs set on fire and our heads cut open. We had lived in a state of alert, a kind of constant terror, our brains flooding with cortisol because we knew that any of those things might happen at any moment. Because Dad always put faith before safety. Because he believed himself right, and he kept on believing himself right—after the first car crash, after the second, after the bin, the fire, the pallet. And it was us who paid.

According to scientists, there are three stages of love: lust, attraction, and attachment. And, it turns out, each of the stages is orchestrated by chemicals—neurotransmitters—in the brain. As you might expect, lust is ruled by testosterone and estrogen. The second stage, attraction, is governed by dopamine and serotonin. When, for example, couples report feeling indescribably happy in each other’s presence, that’s dopamine, the pleasure hormone, doing its work. Taking cocaine fosters the same level of euphoria. In fact, scientists who study both the brains of new lovers and cocaine addicts are hard-pressed to tell the difference. The second chemical of the attraction phase is serotonin. When couples confess that they can’t stop thinking about each other, it’s because their serotonin level has dropped. People in love have the same low serotonin levels as people with OCD. The reason they can’t stop thinking about each other is that they are literally obsessed. Oxytocin and vasopressin control the third stage: attachment or long-term bonding. Oxytocin is released during orgasm and makes you feel closer to the person you’ve had sex with. It’s also released during childbirth and helps bond mother to child. Vasopressin is released postcoitally. Natasha knows these facts cold. Knowing them helped her get over Rob’s betrayal. So she knows: love is just chemicals and coincidence. So why does Daniel feel like something more?

Yoga is an exact science in the form of poetry when we measure the flow of neurotransmitters in the brain.

Pesticides poison the main brain happy hormone or neurotransmitter, acetyl choline.

My mind was flying high that day, courtesy of whatever witches' brew of neurotransmitters God had programmed into my genes...

The nucleus accumbens, a region of the forebrain associated with pleasure, grows to its largest size in one’s teenage years. At the same time, the body produces more dopamine, the neurotransmitter that conveys pleasure, than it ever will again. That is why the sensations you feel as a teenager are more intense than at any other time of life. But it also means that seeking pleasure is an occupational hazard for teenagers. The leading cause of deaths among teenagers is accidents—and the leading cause of accidents is simply being with other teenagers. When more than one teenager is in a car, for instance, the risk of an accident multiplies by 400 percent.

According to scientists, there are three stages of love: lust, attraction, and attachment. And, it turns out, each of the stages is orchestrated by chemicals – neurotransmitters – in the brain.

My apologies. Time and isolation do strange things. Of course, the levels of serotonin do not help,” the vampire said. “The what?” Domingo asked. “Serotonin. A neurotransmitter. The low levels in our brains make us violent, impulsive, self-destructive. It’s worse in some types than others.

Emergencies send sparks to the darkest corner of us. They wake up our hormones and neurotransmitters, they remove the rust from our body and mind, and they show us we can still handle crisis with poise. Emergencies push us to our limits. At those limits, the best inside us comes out. The eyes of our mind open, exceptional vision occurs to us, and we have a chance to become extraordinary.

Knowledge emerged about synapses, neurotransmitter-ology was born, and this idea was modified—a new memory requires the formation of a new synapse, a new connection between an axon terminal and a dendritic spine.

Crazy’ is a term that’s used incorrectly and far too often. It’s also used with stigma and finality.” He tapped his head. “We’re all chemicals, Adrian. Our bodies, our brains. It’s a simple yet vastly sophisticated system, and every so often, something goes awry. A cell mutation. A neuron misfiring. A lack of a neurotransmitter.

When people have trouble with their emotions – a bout of anxiety or depression, say, or seasonal gloominess - they often want science to pinpoint an offending neurotransmitter in the way that a witness picks the perp out of a lineup. Is it excessive norepinephrine, too little dopamine, errant estrogen? The answer is apt to dissatisfy: no single suspect can be fingered with confidence because the question itself attributes a fallacious simplicity to the brain.

This,” Alaric explained to Sarah in what he thought was a kindly voice, “isn’t love you’re feeling. Only dopamine. Because Felix isn’t like anyone else you know. Being a creature of the night, he’s new and exciting and activates a neurotransmitter in your brain that releases feelings of euphoria when you’re around him…especially because you know you can never actually be together, and he seems complicated, and perhaps even sensitive and vulnerable at times. But I can assure you: he’s anything but.” “How dare you?” Sarah demanded hotly. “It isn’t dopa…whatever! It’s love! Love!

The more a sufferer concentrates on his symptoms, the deeper those symptoms are etched into his neural circuits. In the worst cases, the mind essentially trains itself to be sick. Many addictions, too, are reinforced by the strengthening of plastic pathways to the brain. Even very small doses of addictive drugs can dramatically alter the flow of neurotransmitters in a person’s synapses, resulting in long-lasting alterations in brain circuitry and function. In some cases, the buildup of certain kinds of neurotransmitters, such as dopamine, a pleasure-producing cousin to adrenaline, seems to actually trigger the turning on or off particular genes, bringing even stronger cravings for the drug. The vital path turns deadly.

feel an emotion it is necessary but not sufficient that neural signals from viscera, from muscles and joints, and from neurotransmitter nuclei—all of which are activated during the process of emotion—reach certain subcortical nuclei and the cerebral cortex. Endocrine and other chemical signals also reach the central nervous system via the bloodstream among other routes.

The artificial intelligence pioneer Marvin Minsky once defined free will as “internal forces I do not understand.”26 People intuitively believe in free will, not just because we have this terrible human need for agency but also because most people know next to nothing about those internal forces. And even the neuroscientist on the witness stand can’t accurately predict which individual with extensive frontal damage will become the serial murderer, because science as a whole still knows about only a handful of those internal forces. Shattered bone → inflammation → constricted movement is easy. Neurotransmitters + hormones + childhood + ____ + ____ + isn’t.

An imbalance of these neurotransmitters is why some people with attention-deficit/hyperactivity disorder (ADHD) come across as stress junkies. They have to get stressed to focus. It’s one of the primary factors in procrastination. People learn to wait until the Sword of Damocles is ready to fall—it’s only then, when stress unleashes norepinephrine and dopamine, that they can sit down and do the work.

The biochemistry of pleasure can counteract the biochemistry of aging. Nitric oxide is the über-neurotransmitter that increases and balances levels of all the others: endorphins, dopamine, serotonin, oxytocin (a bonding neurotransmitter released while breast-feeding, experiencing an orgasm, or even enjoying the company of others), and DMT, which is generated in the pineal gland in the brain and probably plays a role in dreaming.3

No drugs here, no manipulation of neurotransmitters that leaves our worldly problems unattended. And no talking cures because explicit insight is not needed. All that is required is courage: the courage to encounter discomfort and stay with it long enough to be changed by it, strengthened.

When dopamine and norepinephrine are working together, it’s easier to know what to focus on and what tasks need to be carried out. If you have ADHD, your brain’s inability to access these neurotransmitters in adequate amounts is part of what leads to distractibility and an inability to focus, which are hallmarks of the condition.

In a very real way, attention is a drug. Like dope, attention makes people feel good by delivering a ‘’hit’’ of certain neurotransmitters (chemicals that transmit, or block the transmission of electrochemical currents) in the brain. Like anything that does this (viz., sex, risk-taking, power), in excessive amounts it’s addictive. And, simply because it works, nothing is as addictive as a pain killer. Hence Narcissus is well-named from the Greek word for narcosis. Attention is his pain killer.

Each electrical pulse—and resulting squirt of neurotransmitter—is not an order commanding the next neuron’s actions; it is more like a vote on what the next neuron should do. The whole pattern of activity is like a presidential election. Everyone votes on who the president should be, and depending on those votes, the country veers off in one direction or another. If you can change the number of votes in a few key swing states by only a few percentage points, you can dramatically change the course of the country. The same is true of the brain. By changing the firing rate of neurons in a few key regions, you can influence the pattern of activity in the entire brain.

Stress is one of the biggest causes of epigenetic change, because it knocks your body out of balance. It comes in three forms: physical stress (trauma), chemical stress (toxins), and emotional stress (fear, worry, being overwhelmed, and so on). Each type can set off more than 1,400 chemical reactions and produce more than 30 hormones and neurotransmitters. When that chemical cascade of stress hormones is triggered, your mind influences your body through the autonomic nervous system and you experience the ultimate

At Stage Four of EBV, viral neurotoxins flood the body’s bloodstream and travel to the brain, where they short out neurotransmitters; plus the virus inflames or goes after the nerves throughout the body, making them sensitive and even allergic to the neurotoxins. As a result, it’s common to experience heavier brain fog, memory loss, confusion, depression, anxiety, migraines, joint pain, nerve pain, heart palpitations, eye floaters, restless legs, ringing in the ears, insomnia, difficulty healing from injuries, and more.

Massage reduces pain because the oxytocin system activates painkilling endorphins. Massage also improves sleep and reduces fatigue by increasing serotonin and dopamine and decreasing the stress hormone cortisol. So if you’re feeling out of sorts, get a massage. You’ll be actively triggering the neurotransmitter systems that work to make you happier.

Few people will campaign for an alternative vision of black holes or magnetic inversion, but we know from experience that about soils, vaccines, earthworms, bears, wolves, neurotransmitters, mushrooms, water circulation, or the composition of air, the smallest study will immediately be plunged into a full-scale battle of interpretations. The Critical Zone is not a classroom; the relationship between researchers and the public is anything but purely pedagogical. If we still had any doubts on this point, the pseudocontroversy over the climate suffices to dispel them. There is no evidence that any major corporation has spent a penny to produce ignorance about the detection of the Higgs boson. But denying the climatic mutation is another matter entirely: financing floods in. Ignorance on the part of the public is such a precious commodity that it justifies immense investments.

Valkyrie stood there and waited for her to start making sense. "There is a vegetable-plant hybrid we've been working on, modifying the genes and receptors, mutating the proteins and acids so that they are, in effect, neurotransmitters. Our work on the synapses alone has been quite illuminating." Valkyrie stood there and waited for her to start making sense.

They found that the fetal cells from their sons reached their brains, sprouted branches, and pumped out neurotransmitters. Their sons helped shape their thoughts.

Depression, we are told over and over again, is a brain disease, a chemical imbalance that can be adjusted by antidepressant medication. In an informational brochure issued to inform the public about depression, the US National Institute for Mental Health tells people that 'depressive illnesses are disorders of the brain' and adds that 'important neurotransmitters - chemicals that brain cells use to communicate - appear to be out of balance'. This view is so widespread that it was even proffered by the editors of PLoS [Public Library of Science] Medicine in their summary that accompanied our article. 'Depression,' they wrote, 'is a serious medical illness caused by imbalances in the brain chemicals that regulate mood', and they went on to say that antidepressants are supposed to work by correcting these imbalances. The editors wrote their comment on chemical imbalances as if it were an established fact, and this is also how it is presented by drug companies. Actually, it is not. Instead, even its proponents have to admit that it is a controversial hypothesis that has not yet been proven. Not only is the chemical-imbalance hypothesis unproven, but I will argue that it is about as close as a theory gets in science to being dis-proven by the evidence.

Cannabis affects the brain because brain cells themselves produce cannabis-like neurotransmitters. The first such compound to be identified was christened anandamide, ananda being Sanskrit for “bliss.” The proteins that transmit anandamide’s message to the brain, the receptors, are mainly located in the striatum (hence the blissful feeling) and in the cerebellum (hence the unsteady gait after taking marijuana), in the cerebral cortex (hence the problems with association, the fragmented thoughts and confusion), and in the hippocampus (hence the memory impairment). But there are no receptors in the brain stem areas that regulate blood pressure and breathing. That’s why it’s impossible to take an overdose of cannabis, as opposed to opiates.

First, your brain is temporarily taken over by the promise of reward. At the sight of that strawberry cheesecake, your brain launches a neurotransmitter called dopamine from the middle of your brain into areas of the brain that control your attention, motivation, and action. Those little dopamine messengers tell your brain, “Must get cheesecake NOW, or suffer a fate worse than death.

I knew that this sort of love, technically, was just a neurotransmitter cocktail designed to make you feel invincible and infinite – beyond language, beyond logic – but I also knew that love was as thrilling as it was temporary, a prelude to pain, though I only knew this through reading – which is to say I had not really learned it yet and may never. That little shimmer in the chest. How simple it seems.

Also, isolation leads to chronically lowered levels of the feel-good neurotransmitter serotonin.  It is one of the bizarre ironies of major depression that being depressed causes people to withdraw from the most powerful antidepressant known - rich and varied social contact.  However therein lies a rich lesson also - in some cases one of the quickest and most effective ways to reverse depression is to socialize.

If we were building a consciousness detector, Searle would want it to ascertain that it was squirting biological neurotransmitters. American philosopher Daniel Dennett (born in 1942) would be more flexible on substrate, but might want to determine whether or not the system contained a model of itself and of its own performance. That view comes closer to my own, but at its core is still a philosophical assumption.

Despite the newness of the science and tentativeness of the conclusions that can currently be drawn, changing women's hormones changes women. And this is a big deal. Although we don't yet know that the pill does the research suggests that it probably has a hand in women's mate preferences, our sensitivity to smells, our relationship satisfaction, the functioning of our stress response, the activities of multiple neurotransmitter systems, the activity of multiple hormones, our moods, our persistence in difficult tasks, our ability to learn and remember and our sex drive. And this is probably just the tip of the iceberg.

At the same time, the body produces more dopamine, the neurotransmitter that conveys pleasure, than it ever will again. That is why the sensations you feel as a teenager are more intense than at any other time of life.

My mind was flying high that day, courtesy of whatever witches’ brew of neurotransmitters God had programmed into my genes, and I filled page after page with what I am sure, thinking back on it, were very strange responses.

Our mind is nothing but accumulated thoughts-good or evil recorded from the day the child is born. For memory or thought to work, a brain is needed. Software cannot work without a hardware. When a computer is damaged can we believe that its software is still somewhere in the sky? How can memory or thinking faculty exist outside brain? The neurotransmitters are responsible for the thought process and memory retention and retrival. All are elecrochemical impulses which cannot travel to sky. Our personality, individuality etc. are result of the accumulated thoughts in our brain. It is quality and nature of accumulated thoughts which decides if one is to become a scientist,poet or a terrorist. A guitar in the hands of a layman does not make any sense. If it is in the hands of a musician melodious tunes can come out. A child in the hands of lovable and intelligent parents go to heights.

Throughout the human life span there remains a constant two-way interaction between psychological states and the neurochemistry of the frontal lobes, a fact that many doctors do not pay enough attention to. One result is the overreliance on medications in the treatment of mental disorders. Modern psychiatry is doing too much listening to Prozac and not enough listening to human beings; people’s life histories should be given at least as much importance as the chemistry of their brains. The dominant tendency is to explain mental conditions by deficiencies of the brain’s chemical messengers, the neurotransmitters. As Daniel J. Siegel has sharply remarked, “We hear it said everywhere these days that the experience of human beings comes from their chemicals.” Depression, according to the simple biochemical model, is due to a lack of serotonin — and, it is said, so is excessive aggression. The answer is Prozac, which increases serotonin levels in the brain. Attention deficit is thought to be due in part to an undersupply of dopamine, one of the brain’s most important neurotransmitters, crucial to attention and to experiencing reward states. The answer is Ritalin. Just as Prozac elevates serotonin levels, Ritalin or other psychostimulants are thought to increase the availability of dopamine in the brain’s prefrontal areas. This is believed to increase motivation and attention by improving the functioning of areas in the prefrontal cortex. Although they carry some truth, such biochemical explanations of complex mental states are dangerous oversimplifications — as the neurologist Antonio Damasio cautions: "When it comes to explaining behavior and mind, it is not enough to mention neurochemistry... The problem is that it is not the absence or low amount of serotonin per se that “causes” certain manifestations. Serotonin is part of an exceedingly complicated mechanism which operates at the level of molecules, synapses, local circuits, and systems, and in which sociocultural factors, past and present, also intervene powerfully. The deficiencies and imbalances of brain chemicals are as much effect as cause. They are greatly influenced by emotional experiences. Some experiences deplete the supply of neurotransmitters; other experiences enhance them. In turn, the availability — or lack of availability — of brain chemicals can promote certain behaviors and emotional responses and inhibit others. Once more we see that the relationship between behavior and biology is not a one-way street.

Powerful neurotransmitters in the brain can increase pleasure (dopamine), lead to feelings of happiness and positive mood (serotonin), reduce stress and alleviate pain (endorphins), and enhance a sense of trust and intimacy (oxytocin).

For their neural networks to function, plants use virtually the same neurotransmitters we do, including the two most important: glutamate and GABA (gamma aminobutyric acid). They also utilize, as do we, acetylcholine, dopamine, serotonin, melatonin, epinephrine, norepinephrine, levodopa, indole-3-acetic acid, 5-hydroxyindole acetic acid, testosterone (and other androgens), estradiol (and other estrogens), nicotine, and a number of other neuroactive compounds. They also make use of their plant-specific neurotransmitter, auxin, which, like serotonin, for example, is synthesized from tryptophan. These transmitters are used, as they are in us, for communication within the organism and to enhance brain function.

Environmental influences also affect dopamine. From animal studies, we know that social stimulation is necessary for the growth of the nerve endings that release dopamine and for the growth of receptors that dopamine needs to bind to in order to do its work. In four-month-old monkeys, major alterations of dopamine and other neurotransmitter systems were found after only six days of separation from their mothers. “In these experiments,” writes Steven Dubovsky, Professor of Psychiatry and Medicine at the University of Colorado, “loss of an important attachment appears to lead to less of an important neurotransmitter in the brain. Once these circuits stop functioning normally, it becomes more and more difficult to activate the mind.” A neuroscientific study published in 1998 showed that adult rats whose mothers had given them more licking, grooming and other physical-emotional contact during infancy had more efficient brain circuitry for reducing anxiety, as well as more receptors on nerve cells for the brain’s own natural tranquilizing chemicals. In other words, early interactions with the mother shaped the adult rat’s neurophysiological capacity to respond to stress. In another study, newborn animals reared in isolation had reduced dopamine activity in their prefrontal cortex — but not in other areas of the brain. That is, emotional stress particularly affects the chemistry of the prefrontal cortex, the center for selective attention, motivation and self-regulation. Given the relative complexity of human emotional interactions, the influence of the infant-parent relationship on human neurochemistry is bound to be even stronger. In the human infant, the growth of dopamine-rich nerve terminals and the development of dopamine receptors is stimulated by chemicals released in the brain during the experience of joy, the ecstatic joy that comes from the perfectly attuned mother-child mutual gaze interaction. Happy interactions between mother and infant generate motivation and arousal by activating cells in the midbrain that release endorphins, thereby inducing in the infant a joyful, exhilarated state. They also trigger the release of dopamine. Both endorphins and dopamine promote the development of new connections in the prefrontal cortex. Dopamine released from the midbrain also triggers the growth of nerve cells and blood vessels in the right prefrontal cortex and promotes the growth of dopamine receptors. A relative scarcity of such receptors and blood supply is thought to be one of the major physiological dimensions of ADD. The letters ADD may equally well stand for Attunement Deficit Disorder.

I do wonder what might have happened if [at age sixteen] I could have just talked to someone, and they could have helped me learn about what I could do on my own to be a healthy person. I never had a role model for that. They could have helped me with my eating problems, and my diet and exercise, and helped me learn how to take care of myself. Instead, it was you have this problem with your neurotransmitters, and so here, take this pill Zoloft, and when that didn’t work, it was take this pill Prozac, and when that didn’t work, it was take this pill Effexor, and then when I started having trouble sleeping, it was take this sleeping pill,” she says, her voice sounding more wistful than ever. “I am so tired of the pills.

exercise triggers a whole host of beneficial processes for your brain.  One of the most important is the release of brain-derived neurotrophic factor (BDNF), which acts as a kind of “fertiliser” for the brain, triggering repair and neuronal growth.

Research to date has shown that, like many other stressors, grief frequently leads to changes in the endocrine, immune, autonomic nervous, and cardiovascular systems; all of these are fundamentally influenced by brain function and neurotransmitters.” There

Pattern recognition is so basic that the brain's pattern detection modules and its reward circuitry became inextricably linked. Whenever we successfully detect a pattern-or think we detect a pattern-the neurotransmitters responsible for sensations of pleasure squirt through our brains. If a pattern has repeated often enough and successfully enough in the past, the neurotransmitter release occurs in response to the mere presence of suggestive cues, long before the expected outcome of that pattern actually occurs. Like the study participants who reported seeing regular sequences in random stimuli, we will use alomst any pretext to get our pattern recognition kicks. Pattern recognition is the most primitive form of analogical reasoning, part of the neural circuitry for metaphor. Monkeys, rodents, and birds recognize patterns, too. What distinguishes humans from other species, though, is that we have elevated pattern recognition to an art. "To understand," the philosopher Isaiah Berlin observed, "is to perceive patterns." Metaphor, however, is not the mere detection of patterns; it is the creation of patterns, too. When Robert Frost wrote, "A bank is a place where they lend you an umbrella in fair weather and ask for it back when it begins to rain" his brain created a pattern connecting umbrellas to banks, a pattern retraced every time someone else reads this sentence. Frost believed passionately that an understanding of metaphor was essential not just to survival in university literature courses but also to survival in daily life.

Because we are not powerless biochemical machines, popping a pill every time we are mentally or physically out of tune is not the answer. Drugs and surgery are powerful tools when they are not overused, but the notion of simple drug fixes is fundamentally flawed. Every time a drug is introduced into the body to correct function A, it inevitably throws off function B, C, or D. It is not gene-directed hormones and neurotransmitters that control our bodies and our minds; our beliefs control our bodies, our minds, and thus our lives … Oh ye of little belief!

If we all loved a little harder, cared a little more, hugged a little stronger, and opened our circles a little wider, fewer people would feel lonely and depressed. Our brains would be awash with happy neurotransmitters, and we would all feel—as we fundamentally are—part of the connected species.

EVERYTHING I KNOW about tears I learned from Meret, who had to do a science presentation on them once. She had four giant photographs on easels, X-ray crystallography of onion tears, tears of change, laughing tears, tears of grief. Close up, they look completely different from each other, because they are. Emotional tears, for example, have protein-based hormones in them, including a neurotransmitter called leucine-enkephalin, which is a natural painkiller. Onion tears are less sticky, and disappear more quickly from a person’s cheeks. Although all tears have salt, water, and lysozyme—the main chemical in tears—how the crystals form differs, due to other ingredients. So onion tears look as dense as brocade. Tears of change resemble the fervent swarm of bees in a hive. Laughing tears are reminiscent of the inside of a lava lamp, with smarter angles. And tears of grief call to mind the earth, as seen from above.

Our lives are shaped as profoundly by personality as by gender or race. And the single most important aspect of personality—the “north and south of temperament,” as one scientist puts it—is where we fall on the introvert-extrovert spectrum. Our place on this continuum influences our choice of friends and mates, and how we make conversation, resolve differences, and show love. It affects the careers we choose and whether or not we succeed at them. It governs how likely we are to exercise, commit adultery, function well without sleep, learn from our mistakes, place big bets in the stock market, delay gratification, be a good leader, and ask “what if.”* It’s reflected in our brain pathways, neurotransmitters, and remote corners of our nervous systems. Today introversion and extroversion are two of the most exhaustively researched subjects in personality psychology, arousing the curiosity of hundreds of scientists.

Dr. Helen Fisher divides love into three categories that correspond to different hormones and brain systems. Her analysis of the data suggests that high androgen and estrogen levels generate lust, romantic love correlates with high dopamine and norepinephrine and low serotonin, and attachment is driven by oxytocin and vasopressin. To make matters more complicated, these three systems interact. For example, testosterone can “kickstart the two love neurotransmitters while an orgasm can elevate the attachment hormone,” according to Fisher. “Don’t copulate with people you don’t want to fall in love with,” she warns.4

In the 1960s, depression was thought to be a matter of having too little of the neurotransmitter norepinephrine. Then, a few years later, the theory changed to a deficiency of serotonin. We now know it’s much more complicated. Sure serotonin and norepinephrine are involved, but so are dopamine and numerous other neurochemicals.

the following supplements are recommended specifically for MS. They’ll help reduce pain and protect your myelin sheath as you heal from EBV: EPA & DHA (eicosapentaenoic acid and docosahexaenoic acid): omega-3 fats to help protect and fortify the myelin nerve sheath. Be sure to buy a plant-based (not fish-based) version. L-glutamine: amino acid that removes toxins such as MSG from the brain and protects neurons. Lion’s mane: medicinal mushroom that helps protect the myelin sheath and support neuron function. ALA (alpha lipoic acid): helps repair damaged neurons and neurotransmitters. Also helps mend the myelin nerve sheath. Monolaurin: fatty acid that kills virus cells, bacteria cells, and other bad microbes (e.g., mold) in the brain. Curcumin: component of turmeric that reduces inflammation of the central nervous system and relieves pain. Barley grass juice extract powder: contains micronutrients that feed the central nervous system. Also helps feed brain tissue, neurons, and the myelin nerve sheath.

What worries me is the acceptance of the importance of feelings without any effort to understand their complex biological and sociocultural machinery. The best example of this attitude can be found in the attempt to explain bruised feelings or irrational behavior by appealing to surface social causes or the action of neurotransmitters, two explanations that pervade the social discourse as presented in the visual and printed media; and in the attempt to correct personal and social problems with medical and nonmedical drugs. It is precisely this lack of understanding of the nature of feelings and reason (one of the hallmarks of the "culture of complaint") that is cause for alarm.

In class I had been taught about neurotransmitters and their effect on brain chemistry; I understood that disease is not a choice. This knowledge might have made me sympathetic to my father, but it didn't. I felt only anger. WE were the ones who paid for it, I thought. We had been bruised and gashed and concussed, had our legs set on fire and our heads cut open.

So you aren’t still in love with her?” I ask, eyebrows up, curious. “You’re over it? Over her? Sayonara, Daisy—” “Well—” His brows bend in the middle. BJ gives me a gentle but firm smile. “Magnolia.” “Oh—” I look at my fiancé. “Too much?” He gives me a tight smile. “You could try not talking for twenty seconds. See what happens.” I don’t do that. Instead I give Tiller an apologetic smile. “See, I was recently diagnosed with ADHD—” “Oh.” Tiller nods, not knowing what to say. “It impairs my prefrontal cortex—something about a neurotransmitter in the brain and then also lower levels of dopamine—which is so rude—don’t you think that’s so rude? Dopamine’s pretty nice—my doctor said it’s probably why I love shopping so much. And sex—

It is important to note that the design of an entire brain region is simpler than the design of a single neuron. As discussed earlier, models often get simpler at a higher level—consider an analogy with a computer. We do need to understand the detailed physics ofsemiconductors to model a transistor, and the equations underlying a single real transistor are complex. A digital circuit that multiples two numbers requires hundreds of them. Yet we can model this multiplication circuit very simply with one or two formulas. An entire computer with billions of transistors can be modeled through its instruction set and register description, which can be described on a handful of written pages of text and formulas. The software programs for an operating system, language compilers, and assemblers are reasonably complex, but modeling a particular program—for example, a speech recognition programbased on hierarchical hidden Markov modeling—may likewise be described in only a few pages of equations. Nowhere in such a description would be found the details ofsemiconductor physics or even of computer architecture. A similar observation holds true for the brain. A particular neocortical pattern recognizer that detects a particular invariant visualfeature (such as a face) or that performs a bandpass filtering (restricting input to a specific frequency range) on sound or that evaluates the temporal proximity of two events can be described with far fewer specific details than the actual physics and chemicalrelations controlling the neurotransmitters, ion channels, and other synaptic and dendritic variables involved in the neural processes. Although all of this complexity needs to be carefully considered before advancing to the next higher conceptual level, much of it can be simplified as the operating principles of the brain are revealed.

Serotonin, a brain neurotransmitter, is known to be low in some depressions; studies show that normal sunlight causes the body to release serotonin, which is one reason people living far from the equator feel rejuvenated and in a good mood on sunny holidays. Laser light also releases serotonin, as well as other important brain chemicals, such as endorphins, which lower pain, and acetylcholine, which is essential for learning—and which might help an injured brain relearn mental abilities that have been lost. Kahn, Naeser, and the Harvard group believe that laser light affects the cerebrospinal fluid as well. Kahn believes that the cerebral spinal fluid and the blood vessels carry the photons into the brain, where they influence the brain cells, as they might other cells. The scientific research on this pathway is in its infancy.

In contrast to dopamine-fueled feelings of pleasure, feelings of happiness are caused by another neurotransmitter—serotonin. Serotonin also helps create feelings of contentedness, significance, and importance. Among other functions, serotonin is a mood stabilizer. Sure, dopamine will give you the quick pleasure rush, but serotonin will keep you happy in the long term—a positive upbeat mood that chases the blues away.

Brain-imaging research is showing that glowing screens - like those of iPads - are as stimulating to the brain's pleasure centre and as able to increase levels of dopamine (the primary feel-good neurotransmitter) as much as sex does. This brain-orgasm effect is what makes screen so addictive for adults, but even more so for children with still-developing brains that just aren't equipped to handle that level of stimulation

The results of decades of neurotransmitter-depletion studies point to one inescapable conclusion: low levels or serotonin, norepinephrine or dopamine do not cause depression. here is how the authors of the most complete meta-analysis of serotonin-depletion studies summarized the data: "Although previously the monoamine systems were considered to be responsible for the development of major depressive disorder (MDD), the available evidence to date does not support a direct causal relationship with MDD. There is no simple direct correlation of serotonin or norepinephrine levels in the brain and mood.' In other words, after a half-century of research, the chemical-imbalance hypothesis as promulgated by the drug companies that manufacture SSRIs and other antidepressants is not only with clear and consistent support, but has been disproved by experimental evidence.

steep taper, seven day timetable, plenty of loperamide; magnesium supplements and free form amino acids to replenish my burnt-out neurotransmitters; protein powder, electrolyte powder, melatonin (and weed) for sleep as well as various herbal tinctures and potions my fashion intern swore by, licorice root and milk thistle, nettles and hops and black cumin seed oil, valerian root and skullcap extract. I had a shopping bag from the health food store with all the stuff

The sympathetic nervous system (SNS) mediates the body’s response to arousing circumstances, for example, producing the famed “fight or flight” stress response. To use the feeble joke told to first-year medical students, the SNS mediates the “four Fs—fear, fight, flight, and sex.” Particular midbrain/brain-stem nuclei send long SNS projections down the spine and on to outposts throughout the body, where the axon terminals release the neurotransmitter norepinephrine.

depression can occur because of biological factors such as genetic predispositions, hormonal changes (including menopause, childbirth or thyroid problems) and differences in biochemistry (an imbalance of naturally occurring substances called neurotransmitters in the brain and spinal cord). In other cases, depression is caused by psychological factors, severe life stressors, substance abuse and certain medical conditions that affect the way your brain regulates your moods.

The other major hormonal player in your cycle is progesterone. It helps to prepare the uterus for implantation with a healthy fertilized egg and supports pregnancy. If no implantation occurs, progesterone levels drop, and another cycle begins. Progesterone receptors are highly concentrated in the brain. Progesterone can support GABA, the brain’s relaxation neurotransmitter; acts to protect your nerve cells; and supports the myelin sheath that covers neurons. I like to think of progesterone as the “feel-good hormone.” It makes you feel calm and peaceful and encourages sleep. It’s like nature’s Valium, but better, because instead of making your brain fuzzy, it sharpens your thinking. It has also been shown to help with brain injuries by reducing inflammation and counteracting damage. It is so much more than a sex hormone. Progesterone increases during pregnancy, which is why many pregnant women often feel great. Some women with hormonal issues, in fact, feel so much better during pregnancy that they will

In fact, we’re not smart and we have bodies—we’re smart because we have bodies.7 The heart has about 40,000 neurons that play a central role in shaping emotion, perception, and decision making. The stomach and intestines complete this network, containing more than 500 million nerve cells, 100 million neurons, 30 different neurotransmitters, and 90 percent of the body’s supply of serotonin (one of the major neurochemicals responsible for mood and well-being). This “second brain,” as scientists have dubbed it, lends some empirical support to the persistent notion of gut instinct.

ASPARTAME AND MSG: EXCITOTOXINS Aspartame is, in fact, an excitotoxin, one of a group of substances, usually acidic amino acids, that in high amounts react with specialized receptors in the brain, causing destruction of certain types of neurons. A growing number of neurosurgeons and neurologists are convinced that excitotoxins play a critical role in the development of several neurological disorders, including migraines, seizures, learning disorders in children, and neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and amyotrophic lateral sclerosis (ALS).1 Glutamate and aspartate are two powerful amino acids that act as neurotransmitters in the brain in very small concentrations, but they are also commonly available in food additives. Glutamate is in MSG, a flavor enhancer, and in hydrolyzed vegetable protein, found in hundreds of processed foods. Aspartate is one of three components of aspartame (NutraSweet, Equal), a sugar substitute. In higher concentrations as food additives, these chemicals constantly stimulate brain cells and can cause them to undergo a process of cell death known as excitotoxicity—the cells are excited to death.

When we think thoughts, neurotransmitters at one branch of one neuron tree cross the synaptic gap to reach the root of another neuron tree. Once they cross that gap, the neuron fires with an electrical bolt of information. When we continue thinking the same thoughts, the neuron keeps firing in the same ways, strengthening the relationship between the two cells so that they can more readily convey a signal the next time those neurons fire. As a result, the brain shows physical evidence that something was not only learned, but also remembered. This process of selective strengthening is called synaptic potentiation.

Many of us who have observed our own behavior don't need science to prove that technology is altering us, but let's bring some in anyway. Dopamine, the neurotransmitter that records certain experiences in our brain (typically described as pleasurable) and prompts us to repeat them, plays a part not only in sex and drugs, but also the swiping and tapping we do on our smartphones. Scott Barry Kaufman--- scientific director of the Imagination Institute...gave me the straight dope on dopamine. "It's a misconception that dopamine has to do with our feelings of happiness and pleasure," he said. "It's a molecule that helps influence our expectations." Higher levels of dopamine are linked to being more open to new things and novelty seeking. Something novel could be an amazing idea for dinner or a new book. . . or just getting likes on a Facebook post or the ping of a text coming in. Our digital devices activate and hijack this dopamine system extremely well, when we let them. ...Kaufman calls dopamine "the mother of invention" and explains that because we have a limited amount of it, we must be judicious about choosing to spend it on "increasing our wonder and excitement for creating meaning and new things like art--- or on Twitter.

In the brain, the amount of the neurotransmitter dopamine affects the process of salience acquisition and expression. During an acute psychotic state, schizophrenia is associated with an increase in dopamine synthesis, dopamine release, and resting-state synaptic dopamine concentrations.10 Kapur suggests that in psychosis, there is a malfunction in the regulation of dopamine, causing abnormal firing of the dopamine system, leading to the aberrant levels of the neurotransmitter and, thus, aberrant assignment of motivational salience to objects, people, and actions.11 Research supports this claim.12 The altered salience of sensory stimuli results in a conscious experience with very different contents than would normally be there, yet those contents are what constitute Mr. B’s reality and provide the experiences that his cognition must make sense of. When considering the contents of Mr. B’s conscious experience, his hallucinations, his efforts to make sense of his delusions are no longer so wacky, but are possible, though not probable, explanations of what he is experiencing. With this in mind, the behavior that results from his cognitive conclusion seems somewhat more rational. And despite suffering this altered brain function, Mr. B continues to be conscious and aware of his existence.

Freud elevated unconscious processes to the throne of the mind, imbuing them with the power to guide our every thought and deed, and to a significant extent writing free will out of the picture. Decades later, neuroscience has linked genetic mechanisms to neuronal circuits coursing with a multiplicity of neurotransmitters to argue that the brain is a machine whose behavior is predestined, or at least determined, in such a way as seemingly to leave no room for the will. It is not merely that will is not free, in the modern scientific view; not merely that it is constrained, a captive of material forces. It is, more radically, that the will, a manifestation of the mind, does not even exist, because a mind independent of brain does not exist.

Octopuses and their relatives have what Woods Hole researcher Roger Hanlon calls electric skin. For its color palette, the octopus uses three layers of three different types of cells near the skin’s surface—all controlled in different ways. The deepest layer, containing the white leucophores, passively reflects background light. This process appears to involve no muscles or nerves. The middle layer contains the tiny iridophores, each 100 microns across. These also reflect light, including polarized light (which humans can’t see, but a number of octopuses’ predators, including birds, do). The iridophores create an array of glittering greens, blues, golds, and pinks. Some of these little organs seem to be passive, but other iridophores appear to be controlled by the nervous system. They are associated with the neurotransmitter acetylcholine, the first neurotransmitter to be identified in any animal. Acetylcholine helps with contraction of muscles; in humans, it is also important in memory, learning, and REM sleep. In octopuses, more of it “turns on” the greens and blues; less creates pinks and golds. The topmost layer of the octopus’s skin contains chromatophores, tiny sacks of yellow, red, brown, and black pigment, each in an elastic container that can be opened or closed to reveal more or less color. Camouflaging the eye alone—with a variety of patterns including a bar, a bandit’s mask, and a starburst pattern—can involve as many as 5 million chromatophores. Each chromatophore is regulated via an array of nerves and muscles, all under the octopus’s voluntary control.

This should have stopped the schizophrenogenic voodoo right in its tracks. High blood pressure can be lessened with a drug that blocks a receptor for a different type of neurotransmitter, and you conclude that a core problem was too much of that neurotransmitter. But schizophrenic symptoms can be lessened with a drug that blocks dopamine receptors, and you still conclude that the core problem is toxic mothering. Remarkably, that’s what psychiatry’s psychoanalytic ruling class concluded. After fighting the introduction of the medications tooth and nail in America and eventually losing, they came up with an accommodation: neuroleptics weren’t doing anything to the core problems of schizophrenia; they just sedated patients enough so that it is easier to psychodynamically make progress with them about the scars from how they were mothered. The psychoanalytic scumbags even developed a sneering, pejorative term for families (i.e., mothers) of schizophrenic patients who tried to dodge responsibility by believing that it was a brain disease: dissociative-organic types. The influential 1958 book Social Class and Mental Illness: A Community Study (John Wiley), by the Viennese psychiatrist Frederick Redlich, who chaired Yale’s psychiatry department for seventeen years, and the Yale sociologist August Hollingshead, explained it all. Dissociative-organic types were typically lower-class, less educated people, for whom “It’s a biochemical disorder” was akin to still believing in the evil eye, an easy, erroneous explanation for those not intelligent enough to understand Freud. Schizophrenia was still caused by lousy parenting, and nothing was to change in the mainstream for decades.

What no tourist bumf will tell you is that this inlet is suffused with an atmosphere of ineffable sadness. Partly a trick of the light and climatic factors, partly also the lingering residue of an historical tragedy which still resonates through rock and water down seven generations of fretful commemorative attempts and dissonant historical hermeneutics. Now think of grey shading towards gunmetal across an achromatic spectrum; think also of turbid cumulus clouds pouring down five centimeters of rainfall above the national average and you have some idea of the light reflected within the walls of this inlet. This is the type of light which lends itself to vitamin D deficiency, baseline serotonin levels, spluttering neurotransmitters and mild but by no means notional depression. It is the type of light wherein ghosts go their rounds at all hours of the day.

Fisher says that in the late 1990s she began looking into the biology of personality, the genes, neurotransmitters, and specifically, the hormones. She did this in part by studying brain scans of "romantically obsessed" people. Her theory is that four different hormones-estrogen, testosterone, dopamine, and serotonin-mold our personalities and that we look for people who complement us, who provide what we're missing. Her questionnaire is designed to divide us into four different types, each one with a dominant hormone. Some of the questions focus on the moods and personalities she associates with each hormone. Others, such as the question about the length of our fingers, zero in on the chemical itself. Research shows, she says, that those with an index finger shorter than the ring finger have often been exposed to more testosterone while in the womb, while those with longer index fingers will have more estrogen.

As explained in the first chapter, human beings are physically hardwired to constantly move about and exercise. Every day, we build up a lot of stress, and physical exercise provides an outlet to get this out of our system so we can stay healthy. In the modern world, our stress is exacerbated by our incessant consumption of negative news and by rapid changes in our culture and norms. Negativity and confusion add stress to the body. Exercise will help manage this by releasing neurotransmitters, called endorphins, into our body to manage our response. Exercise temporarily mimics the fight-or-flight response that you may feel when you are stressed. But in the long run, it will help calm and de-stress you. Endorphins help calm your responses and ultimately result in removing the built-up stresses from our lives. Studies have shown that people experience positive changes after just one or two cardio sessions. Exercise will also help you sleep, which is directly correlated with lower stress and anxiety.3 Exercise

Flow is an extremely potent response to external events and requires an extraordinary set of signals. The process includes dopamine, which does more than tune signal-to-noise ratios. Emotionally, we feel dopamine as engagement, excitement, creativity, and a desire to investigate and make meaning out of the world. Evolutionarily, it serves a similar function. Human beings are hardwired for exploration, hardwired to push the envelope: dopamine is largely responsible for that wiring. This neurochemical is released whenever we take a risk or encounter something novel. It rewards exploratory behavior. It also helps us survive that behavior. By increasing attention, information flow, and pattern recognition in the brain, and heart rate, blood pressure, and muscle firing timing in the body, dopamine serves as a formidable skill-booster as well. Norepinephrine provides another boost. In the body, it speeds up heart rate, muscle tension, and respiration, and triggers glucose release so we have more energy. In the brain, norepinephrine increases arousal, attention, neural efficiency, and emotional control. In flow, it keeps us locked on target, holding distractions at bay. And as a pleasure-inducer, if dopamine’s drug analog is cocaine, norepinephrine’s is speed, which means this enhancement comes with a hell of a high. Endorphins, our third flow conspirator, also come with a hell of a high. These natural “endogenous” (meaning naturally internal to the body) opiates relieve pain and produce pleasure much like “exogenous” (externally added to the body) opiates like heroin. Potent too. The most commonly produced endorphin is 100 times more powerful than medical morphine. The next neurotransmitter is anandamide, which takes its name from the Sanskrit word for “bliss”—and for good reason. Anandamide is an endogenous cannabinoid, and similarly feels like the psychoactive effect found in marijuana. Known to show up in exercise-induced flow states (and suspected in other kinds), this chemical elevates mood, relieves pain, dilates blood vessels and bronchial tubes (aiding respiration), and amplifies lateral thinking (our ability to link disparate ideas together). More critically, anandamide also inhibits our ability to feel fear, even, possibly, according to research done at Duke, facilitates the extinction of long-term fear memories. Lastly, at the tail end of a flow state, it also appears (more research needs to be done) that the brain releases serotonin, the neurochemical now associated with SSRIs like Prozac. “It’s a molecule involved in helping people cope with adversity,” Oxford University’s Philip Cowen told the New York Times, “to not lose it, to keep going and try to sort everything out.” In flow, serotonin is partly responsible for the afterglow effect, and thus the cause of some confusion. “A lot of people associate serotonin directly with flow,” says high performance psychologist Michael Gervais, “but that’s backward. By the time the serotonin has arrived the state has already happened. It’s a signal things are coming to an end, not just beginning.” These five chemicals are flow’s mighty cocktail. Alone, each packs a punch, together a wallop.

Alcohol is the great impersonator, fooling at least four different receptor molecules. In a quick survey of the functions of these victims, we can see exactly how alcohol works its magic. 1. It slows us down, “relaxing” our neurons. By blocking receptors for our brains’ chief excitatory neurotransmitters, alcohol coats the brain in a bit of molasses, slowing reaction times and slurring speech. We could probably do without this effect. 2. It gives us a pleasant buzz. Acting like cocaine —but much weaker —alcohol blocks dopamine reuptake, increasing the concentration of the happy neurotransmitter in the key parts of our brains. 3. It blocks pain. By stimulating the release of endorphins, alcohol lets us sample the “runner’s high” without even putting on our running shoes. Resembling morphine and heroin in this respect, but again at a greatly reduced magnitude, alcohol spurs our body to produce a little opiate-like high. 4. Alcohol makes us happier, at least while it’s in our system. Like a “do-it-yourself Prozac kit,” alcohol modifies and increases the efficiency of our serotonin receptors.

From another corner of neuroscience, we’re learning about a neurotransmitter called dopamine. Though there are more than fifty neurotransmitters (that we know of), scientists studying substance problems have given dopamine much of their attention. The brain’s reward system and pleasure centers—the areas most impacted by substance use and compulsive behaviors—have a high concentration of dopamine. Some brains have more of it than others, and some people have a capacity to enjoy a range of experiences more than others, owing to a combination of genetics and environment. The thing about dopamine is that it makes us feel really good. We tend to want more of it. It is naturally generated through ordinary, pleasurable activities like eating and sex, and it is the brain’s way of rewarding us—or nature’s way of rewarding the brain—for activities necessary to our survival, individually or as a species. It is the “mechanism by which ‘instinct’ is manifest.” Our brains arrange for dopamine levels to rise in anticipation and spike during a pleasurable activity to make sure we do it again. It helps focus our attention on all the cues that contributed to our exposure to whatever felt good (these eventually become triggers to use, as we explain later). Drugs and alcohol (and certain behaviors) turn on a gushing fire hose of dopamine in the brain, and we feel good, even euphoric. Dopamine produced by these artificial means, however, throws our pleasure and reward systems out of whack immediately. Flooding the brain repeatedly with dopamine has long-term effects and creates what’s known as tolerance—when we lose our ability to produce or absorb our own dopamine and need more and more of it artificially just to feel okay. Specifically, the brain compensates for the flood of dopamine by decreasing its own production of it or by desensitizing itself to the neurotransmitter by reducing the number of dopamine receptors, or both. The brain is just trying to keep a balance. The problem with the brain’s reduction in natural dopamine production is that when you take the substance or behavior out of the picture, there’s not enough dopamine in the brain to make you feel good. Without enough dopamine, there is no interest or pleasure. Then not only does the brain lose the pleasure associated with using, it might not be able to enjoy a sunset or a back rub, either. A lowered level of dopamine, combined with people’s longing for the rush of dopamine they got from using substances, contributes to “craving” states. Cravings are a physiological process associated with the brain’s struggle to regain its normal dopamine balance, and they can influence a decision to keep using a substance even when a person is experiencing negative consequences that matter to him and a strong desire to change. Depending on the length of time and quantities a person has been using, these craving states can be quite uncomfortable and compelling. The dopamine system can and does recover, starting as soon as we stop flooding it. But it takes time, and in the time between shutting off the artificial supply of dopamine and the brain’s rebuilding its natural resources, people tend to feel worse (before they feel better). On a deep, instinctual level, their brains are telling them that by stopping using, something is missing; something is wrong. This is a huge factor in relapse, despite good intentions and effort to change. Knowing this can help you and your loved one make it across this gap in brain reward systems.

if there is no proof that a depressed person has a chemical imbalance, and you choose nevertheless to put that person on a medication that will alter neurotransmitter levels in his or her brain, then in effect you are causing a chemical imbalance rather than curing one. According to Steven Hyman, a neuroscientist and former director of the National Institute of Mental Health, all psychotropic drugs cause “perturbations in neurotransmitter functions.” And this is Whitaker’s main point. We are subjecting millions of brains to drugs that change natural neurotransmission, sometimes radically, disturbing and upsetting the complex interplay inside our heads, clogging neural pathways with excess chemicals, and sometimes causing the entire brain, which is intricately interlinked, to malfunction in ways we do not yet understand. An unmedicated depressed patient does not have a known chemical imbalance in his brain, but once he ingests Prozac, he will. The drug crosses the blood-brain barrier and gets to work, jamming serotonin into the synaptic cleft. Whitaker explains the result this way: “Several weeks later the serotonergic pathway is operating in a decidedly abnormal manner.

So many synapses,' Drisana said. 'Ten trillion synapses in the cortex alone.' Danlo made a fist and asked, 'What do the synapses look like?' 'They're modelled as points of light. Ten trillion points of light.' She didn't explain how neurotransmitters diffuse across the synapses, causing the individual neurons to fire. Danlo knew nothing of chemistry or electricity. Instead, she tried to give him some idea of how the heaume's computer stored and imprinted language. 'The computer remembers the synapse configuration of other brains, brains that hold a particular language. This memory is a simulation of that language. And then in your brain, Danlo, select synapses are excited directly and strengthened. The computer speeds up the synapses' natural evolution.' Danlo tapped the bridge of his nose; his eyes were dark and intent upon a certain sequence of thought. 'The synapses are not allowed to grow naturally, yes?' 'Certainly not. Otherwise imprinting would be impossible.' 'And the synapse configuration – this is really the learning, the essence of another's mind, yes?' 'Yes, Danlo.' 'And not just the learning – isn't this so? You imply that anything in the mind of another could be imprinted in my mind?' 'Almost anything.' 'What about dreams? Could dreams be imprinted?' 'Certainly.' 'And nightmares?' Drisana squeezed his hand and reassured him. 'No one would imprint a nightmare into another.' 'But it is possible, yes?' Drisana nodded her head. 'And the emotions ... the fears or loneliness or rage?' 'Those things, too. Some imprimaturs – certainly they're the dregs of the City – some do such things.' Danlo let his breath out slowly. 'Then how can I know what is real and what is unreal? Is it possible to imprint false memories? Things or events that never happened? Insanity? Could I remember ice as hot or see red as blue? If someone else looked at the world through shaida eyes, would I be infected with this way of seeing things?' Drisana wrung her hands together, sighed, and looked helplessly at Old Father. 'Oh ho, the boy is difficult, and his questions cut like a sarsara!' Old Father stood up and painfully limped over to Danlo. Both his eyes were open, and he spoke clearly. 'All ideas are infectious, Danlo. Most things learned early in life, we do not choose to learn. Ah, and much that comes later. So, it's so: the two wisdoms. The first wisdom: as best we can, we must choose what to put into our brains. And the second wisdom: the healthy brain creates its own ecology; the vital thoughts and ideas eventually drive out the stupid, the malignant and the parasitical.

Here’s how I’ve always pictured mitigated free will: There’s the brain—neurons, synapses, neurotransmitters, receptors, brainspecific transcription factors, epigenetic effects, gene transpositions during neurogenesis. Aspects of brain function can be influenced by someone’s prenatal environment, genes, and hormones, whether their parents were authoritative or their culture egalitarian, whether they witnessed violence in childhood, when they had breakfast. It’s the whole shebang, all of this book. And then, separate from that, in a concrete bunker tucked away in the brain, sits a little man (or woman, or agendered individual), a homunculus at a control panel. The homunculus is made of a mixture of nanochips, old vacuum tubes, crinkly ancient parchment, stalactites of your mother’s admonishing voice, streaks of brimstone, rivets made out of gumption. In other words, not squishy biological brain yuck. And the homunculus sits there controlling behavior. There are some things outside its purview—seizures blow the homunculus’s fuses, requiring it to reboot the system and check for damaged files. Same with alcohol, Alzheimer’s disease, a severed spinal cord, hypoglycemic shock. There are domains where the homunculus and that brain biology stuff have worked out a détente—for example, biology is usually automatically regulating your respiration, unless you must take a deep breath before singing an aria, in which case the homunculus briefly overrides the automatic pilot. But other than that, the homunculus makes decisions. Sure, it takes careful note of all the inputs and information from the brain, checks your hormone levels, skims the neurobiology journals, takes it all under advisement, and then, after reflecting and deliberating, decides what you do. A homunculus in your brain, but not of it, operating independently of the material rules of the universe that constitute modern science. That’s what mitigated free will is about. I see incredibly smart people recoil from this and attempt to argue against the extremity of this picture rather than accept its basic validity: “You’re setting up a straw homunculus, suggesting that I think that other than the likes of seizures or brain injuries, we are making all our decisions freely. No, no, my free will is much softer and lurks around the edges of biology, like when I freely decide which socks to wear.” But the frequency or significance with which free will exerts itself doesn’t matter. Even if 99.99 percent of your actions are biologically determined (in the broadest sense of this book), and it is only once a decade that you claim to have chosen out of “free will” to floss your teeth from left to right instead of the reverse, you’ve tacitly invoked a homunculus operating outside the rules of science. This is how most people accommodate the supposed coexistence of free will and biological influences on behavior. For them, nearly all discussions come down to figuring what our putative homunculus should and shouldn’t be expected to be capable of.

Yatima found verself gazing at a red-tinged cluster of pulsing organic parts, a translucent confusion of fluids and tissue. Sections divided, dissolved, reorganised. It looked like a flesher embryo – though not quite a realist portrait. The imaging technique kept changing, revealing different structures: Yatima saw hints of delicate limbs and organs caught in slices of transmitted dark; a stark silhouette of bones in an X-ray flash; the finely branched network of the nervous system bursting into view as a filigreed shadow, shrinking from myelin to lipids to a scatter of vesicled neurotransmitters against a radio-frequency MRI chirp. There were two bodies now. Twins? One was larger, though – sometimes much larger. The two kept changing places, twisting around each other, shrinking or growing in stroboscopic leaps while the wavelengths of the image stuttered across the spectrum. One flesher child was turning into a creature of glass, nerves and blood vessels vitrifying into optical fibres. A sudden, startling white-light image showed living, breathing Siamese twins, impossibly transected to expose raw pink and grey muscles working side by side with shape-memory alloys and piezoelectric actuators, flesher and gleisner anatomies interpenetrating. The scene spun and morphed into a lone robot child in a flesher's womb; spun again to show a luminous map of a citizen's mind embedded in the same woman's brain; zoomed out to place her, curled, in a cocoon of optical and electronic cables. Then a swarm of nanomachines burst through her skin, and everything scattered into a cloud of grey dust. Two flesher children walked side by side, hand in hand. Or father and son, gleisner and flesher, citizen and gleisner... Yatima gave up trying to pin them down, and let the impressions flow through ver. The figures strode calmly along a city's main street, while towers rose and crumbled around them, jungle and desert advanced and retreated. The artwork, unbidden, sent Yatima's viewpoint wheeling around the figures. Ve saw them exchanging glances, touches, kisses – and blows, awkwardly, their right arms fused at the wrists. Making peace and melting together. The smaller lifting the larger on to vis shoulders – then the passenger's height flowing down to the bearer like an hourglass's sand.

All the substances that are the main drugs of abuse today originate in natural plant products and have been known to human beings for thousands of years. Opium, the basis of heroin, is an extract of the Asian poppy Papaver somniferum. Four thousand years ago, the Sumerians and Egyptians were already familiar with its usefulness in treating pain and diarrhea and also with its powers to affect a person’s psychological state. Cocaine is an extract of the leaves of Erythroxyolon coca, a small tree that thrives on the eastern slopes of the Andes in western South America. Amazon Indians chewed coca long before the Conquest, as an antidote to fatigue and to reduce the need to eat on long, arduous mountain journeys. Coca was also venerated in spiritual practices: Native people called it the Divine Plant of the Incas. In what was probably the first ideological “War on Drugs” in the New World, the Spanish invaders denounced coca’s effects as a “delusion from the devil.” The hemp plant, from which marijuana is derived, first grew on the Indian subcontinent and was christened Cannabis sativa by the Swedish scientist Carl Linnaeus in 1753. It was also known to ancient Persians, Arabs and Chinese, and its earliest recorded pharmaceutical use appears in a Chinese compendium of medicine written nearly three thousand years ago. Stimulants derived from plants were also used by the ancient Chinese, for example in the treatment of nasal and bronchial congestion. Alcohol, produced by fermentation that depends on microscopic fungi, is such an indelible part of human history and joy making that in many traditions it is honoured as a gift from the gods. Contrary to its present reputation, it has also been viewed as a giver of wisdom. The Greek historian Herodotus tells of a tribe in the Near East whose council of elders would never sustain a decision they made when sober unless they also confirmed it under the influence of strong wine. Or, if they came up with something while intoxicated, they would also have to agree with themselves after sobering up. None of these substances could affect us unless they worked on natural processes in the human brain and made use of the brain’s innate chemical apparatus. Drugs influence and alter how we act and feel because they resemble the brain’s own natural chemicals. This likeness allows them to occupy receptor sites on our cells and interact with the brain’s intrinsic messenger systems. But why is the human brain so receptive to drugs of abuse? Nature couldn’t have taken millions of years to develop the incredibly intricate system of brain circuits, neurotransmitters and receptors that become involved in addiction just so people could get “high” to escape their troubles or have a wild time on a Saturday night. These circuits and systems, writes a leading neuroscientist and addiction researcher, Professor Jaak Panksepp, must “serve some critical purpose other than promoting the vigorous intake of highly purified chemical compounds recently developed by humans.” Addiction may not be a natural state, but the brain regions it subverts are part of our central machinery of survival.

REPROGRAMMING MY BIOCHEMISTRY A common attitude is that taking substances other than food, such as supplements and medications, should be a last resort, something one takes only to address overt problems. Terry and I believe strongly that this is a bad strategy, particularly as one approaches middle age and beyond. Our philosophy is to embrace the unique opportunity we have at this time and place to expand our longevity and human potential. In keeping with this health philosophy, I am very active in reprogramming my biochemistry. Overall, I am quite satisfied with the dozens of blood levels I routinely test. My biochemical profile has steadily improved during the years that I have done this. For boosting antioxidant levels and for general health, I take a comprehensive vitamin-and-mineral combination, alpha lipoic acid, coenzyme Q10, grapeseed extract, resveratrol, bilberry extract, lycopene, silymarin (milk thistle), conjugated linoleic acid, lecithin, evening primrose oil (omega-6 essential fatty acids), n-acetyl-cysteine, ginger, garlic, l-carnitine, pyridoxal-5-phosphate, and echinacea. I also take Chinese herbs prescribed by Dr. Glenn Rothfeld. For reducing insulin resistance and overcoming my type 2 diabetes, I take chromium, metformin (a powerful anti-aging medication that decreases insulin resistance and which we recommend everyone over 50 consider taking), and gymnema sylvestra. To improve LDL and HDL cholesterol levels, I take policosanol, gugulipid, plant sterols, niacin, oat bran, grapefruit powder, psyllium, lecithin, and Lipitor. To improve blood vessel health, I take arginine, trimethylglycine, and choline. To decrease blood viscosity, I take a daily baby aspirin and lumbrokinase, a natural anti-fibrinolytic agent. Although my CRP (the screening test for inflammation in the body) is very low, I reduce inflammation by taking EPA/DHA (omega-3 essential fatty acids) and curcumin. I have dramatically reduced my homocysteine level by taking folic acid, B6, and trimethylglycine (TMG), and intrinsic factor to improve methylation. I have a B12 shot once a week and take a daily B12 sublingual. Several of my intravenous therapies improve my body’s detoxification: weekly EDTA (for chelating heavy metals, a major source of aging) and monthly DMPS (to chelate mercury). I also take n-acetyl-l-carnitine orally. I take weekly intravenous vitamins and alpha lipoic acid to boost antioxidants. I do a weekly glutathione IV to boost liver health. Perhaps the most important intravenous therapy I do is a weekly phosphatidylcholine (PtC) IV, which rejuvenates all of the body’s tissues by restoring youthful cell membranes. I also take PtC orally each day, and I supplement my hormone levels with DHEA and testosterone. I take I-3-C (indole-3-carbinol), chrysin, nettle, ginger, and herbs to reduce conversion of testosterone into estrogen. I take a saw palmetto complex for prostate health. For stress management, I take l-theonine (the calming substance in green tea), beta sitosterol, phosphatidylserine, and green tea supplements, in addition to drinking 8 to 10 cups of green tea itself. At bedtime, to aid with sleep, I take GABA (a gentle, calming neuro-transmitter) and sublingual melatonin. For brain health, I take acetyl-l-carnitine, vinpocetine, phosphatidylserine, ginkgo biloba, glycerylphosphorylcholine, nextrutine, and quercetin. For eye health, I take lutein and bilberry extract. For skin health, I use an antioxidant skin cream on my face, neck, and hands each day. For digestive health, I take betaine HCL, pepsin, gentian root, peppermint, acidophilus bifodobacter, fructooligosaccharides, fish proteins, l-glutamine, and n-acetyl-d-glucosamine. To inhibit the creation of advanced glycosylated end products (AGEs), a key aging process, I take n-acetyl-carnitine, carnosine, alpha lipoic acid, and quercetin. MAINTAINING A POSITIVE “HEALTH SLOPE” Most important,