Neurons Image Quotes

When the brain is working to remember something, similar patterns of neurons fire as they did during the perception of the original event. These networks are linked, and each time we revisit them, they become stronger and more associated. But they need the proper retrieval cues--words, smells, images-- for them to be brought back as memories

At this moment, in this place, the shifting action potential in my neurons cascade into certain arrangements, patterns, thoughts; they flow down my spine, branch into my arms, my fingers, until muscles twitch and thought is translated into motion; mechanical levers are pressed; electrons are rearranged; marks are made on paper. At another time, in another place, light strikes the marks, reflects into a pair of high-precision optical instruments sculpted by nature after billions of years of random mutations; upside-down images are formed against two screens made up of millions of light-sensitive cells, which translate light into electrical pulses that go up the optic nerves, cross the chiasm, down the optic tracts, and into the visual cortex, where the pulses are reassembled into letters, punctuation marks, words, sentences, vehicles, tenors, thoughts. The entire system seems fragile, preposterous, science fictional.

Examples of fractals are everywhere in nature. They can be found in the patterns of trees, branches, and ferns, in which each part appears to be a smaller image of the whole. They are found in the branch-like patterns of river systems, lightning, and blood vessels. They can be seen in snowflakes, seashells, crystals, and mountain ranges. We can even see the holographic and fractal-like nature of reality in the structure of the Universe itself, as the clusters of galaxies and dark matter resemble the neurons in our brain, the mycelium network of fungi, as well as the network of the man-made Internet.

In the latest brain image studies, we can see real-time movies of individual interneuronal connections actually creating new synapses (connection points between neurons), so we can see our brain create our thoughts and in turn see our thoughts create our brain.

When I change I change fast. The moon drags the whatever-it-is up from the earth and it goes through me with crazy wriggling impatience. I picture it as an electrical discharge, entering at my soles and racing upwards in haywire detonations that shock the bones and explode the neurons. The magic's dark red, violent, compressed. I get random flashes of mundane memory-- pushing a shopping cart around Met Foods; opening my apartment window; standing on a subway platform; saying to someone, No, that's carbohydrates in the evenings-- intercut with images of the kills; a white male body on an oil-stained warehouse floor; a solitary trailer with a storm lamp burning; a female thigh releasing a dark arc of blood; my clawed hand scooping out a still-hot heart. This is the Curse's neatest trick: one type of memory doesn't destroy the other. It's still you. It's still all you. You wouldn't think you were built to bear such opposites, but you are. You'd think the system would crash, but it doesn't.

If an answer didn’t come to her during this learning phase, she let the subject settle inside her. She no longer thought about it consciously, allowing instead some dark and muscled lobe of her brain to take over. The issue was broken down into components and absorbed, images from the material occasionally appearing in her thoughts like neuronal burps. Every once in awhile she’d flip through her notes, having no expectations but going through the ritual in order to goose her brain along. After her mind had worked on the problem like this for long enough—a few days, a month, maybe a whole year—the answer would suddenly hit her. The solution glittering and fully realized, as obvious as though someone much smarter had handed it to her, frustrated with how long she was taking.

What to call it - the spark of God? Survival instinct? The souped-up computer of an apex brain evolved from eons in the R&D of natural selection? You could practically see the neurons firing in the kid’s skull. His body was all spring and torque, a bundle of fast-twitch muscles that exuded faint floral whiffs of ripe pear. So much perfection in such a compact little person - Billy had to tackle him from time to time, wrestle him squealing to the ground just to get that little rascal in his hands, just your basic adorable thirty-month-old with big blue eyes clear as chlorine pools and Huggies poking out of his stretchy-waist jeans. So is this what they mean by the sanctity of life? A soft groan escaped Billy when he thought about that, the war revealed in this fresh and gruesome light. Oh. Ugh. Divine spark, image of God, suffer the little children and all that - there’s real power when words attach to actual things. Made him want to sit right down and weep, as powerful as that. He got it, yes he did, and when he came home for good he’d have to meditate on this, but for now it was best to compartmentalize, as they said, or even better not to mentalize at all.

Though advances in imaging technology have allowed neuroscientists to grasp much of the basic topography of the brain, and studies of neurons have given us a clear picture of what happens inside and between individual brain cells, science is still relatively clueless about what transpires in the circuitry of the cortex, the wrinkled outer layer of the brain that allows us to plan into the future, do long division, and write poetry, and which holds most of our memories.

Through all this relentlessly advancing technology the same brain gropes through its diminishing neurons for images and narratives that will lift lumps out of the earth and put them under the glass case of published print. With ominous frequency, I can’t think of the right word. I know there is a word; I can visualize the exact shape it occupies in the jigsaw puzzle of the English language. But the word itself, with its precise edges and unique tint of meaning, hangs on the misty rim of consciousness. Eventually, with shamefaced recourse to my well-thumbed thesaurus or to a germane encyclopedia article, I may pin the word down, only to discover that it unfortunately rhymes with the adjoining word of the sentence.

But now I speculate re the ants' invisible organ of aggregate thought... if, in a city park of broad reaches, winding paths, roadways, and lakes, you can imagine seeing on a warm and sunny Sunday afternoon the random and unpredictable movement of great numbers of human beings in the same way... if you watch one person, one couple, one family, a child, you can assure yourself of the integrity of the individual will and not be able to divine what the next moment will bring. But when the masses are celebrating a beautiful day in the park in a prescribed circulation of activities, the wider lens of thought reveals nothing errant, nothing inconstant or unnatural to the occasion. And if someone acts in a mutant un-park manner, alarms go off, the unpredictable element, a purse snatcher, a gun wielder, is isolated, surrounded, ejected, carried off as waste. So that while we are individually and privately dyssynchronous, moving in different ways, for different purposes, in different directions, we may at the same time comprise, however blindly, the pulsing communicating cells of an urban over-brain. The intent of this organ is to enjoy an afternoon in the park, as each of us street-grimy urbanites loves to do. In the backs of our minds when we gather for such days, do we know this? How much of our desire to use the park depends on the desires of others to do the same? How much of the idea of a park is in the genetic invitation on nice days to reflect our massive neuromorphology? There is no central control mechanism telling us when and how to use the park. That is up to us. But when we do, our behavior there is reflective, we can see more of who we are because of the open space accorded to us, and it is possible that it takes such open space to realize in simple form the ordinary identity we have as one multicellular culture of thought that is always there, even when, in the comparative blindness of our personal selfhood, we are flowing through the streets at night or riding under them, simultaneously, as synaptic impulses in the metropolitan brain. Is this a stretch? But think of the contingent human mind, how fast it snaps onto the given subject, how easily it is introduced to an idea, an image that it had not dreamt of thinking of a millisecond before... Think of how the first line of a story yokes the mind into a place, a time, in the time it takes to read it. How you can turn on the radio and suddenly be in the news, and hear it and know it as your own mind's possession in the moment's firing of a neuron. How when you hear a familiar song your mind adopts its attitudinal response to life before the end of the first bar. How the opening credits of a movie provide the parameters of your emotional life for its ensuing two hours... How all experience is instantaneous and instantaneously felt, in the nature of ordinary mind-filling revelation. The permeable mind, contingently disposed for invasion, can be totally overrun and occupied by all the characteristics of the world, by everything that is the case, and by the thoughts and propositions of all other minds considering everything that is the case... as instantly and involuntarily as the eye fills with the objects that pass into its line of vision.

Imagine: inside, in the nerves, in the head―that is, these nerves are there in the brain... (damn them!) there are sort of little tails, the little tails of those nerves, and as soon as they begin quivering... that is, you see, I took at something with my eyes and begin quivering, those little tails... and when they quiver, then an image appears... it doesn't appear at once, but an instant, a second, passes... and then something like a moment appears; that is, not a moment―devil take the moment!―but an image; that is, an object, or an action, damn it! That's why I see and then think, because of those tails, not because I've got a soul, and that I am some sort of image and likeness. All that is nonsense! Rakitin explained it all to me yesterday, brother, and it simply bowled me over. It's magnificent, Alyosha, this science! A new man's arising―that I understand... And yet I am sorry to lose God!

Every act of communication is a miracle of translation. At this moment, in this place, the shifting action potentials in my neurons cascade into certain arrangements, patterns, thoughts; they flow down my spine, branch into my arms, my fingers, until muscles twitch and thought is translated into motion; mechanical levers are pressed; electrons are rearranged; marks are made on paper. At another time, in another place, light strikes the marks, reflects into a pair of high precision optical instruments sculpted by nature after billions of years of random mutations; upside-down images are formed against two screens made up of millions of light-sensitive cells, which translate light into electrical pulses that go up optic nerves, cross the chasm, down the optic tracts, and into the visual cortex, where the pulses are reassembled into letters, punctuation marks, words, sentences, vehicles, tenors, thoughts. The entire system seems fragile, preposterous, science fictional. Who can say if the thoughts you have in your mind as you read these words are the same thoughts I had in my mind as I typed them? We are different, you and I, and the qualia of our consciousnesses are as divergent as two stars at the ends of the universe. And yet, whatever has been lost in translation in the long journey of my thoughts through the maze of civilization to your mind, I think you do understand me, and you think you do understand me. Our minds managed to touch, if but briefly and imperfectly.

He wondered where his mind had wandered this time, what life it had lived as a trail of neurons sped through networks of possibilities particle-fast, too rapid to catch without a hadron collider, causing super quarks of weirdness and leaving him with only a vague after-image like a melting dream. He had to accept that he couldn’t catch all his thoughts, all the things going on in his body, the processes which slipped by in the background just leaving a shadow, an itch, the grain of sand that probably wouldn’t become a pearl, a blazing after-trace that lives a second then is gone forever. All those possibilities occurring in a second of frantic life: it never ceased to amaze him. The world was an incredible and beautifully constructed thing. However, there wasn’t really time for a wank.

Do you know how the brain works? Do you have any idea of what we know about how the brain and consciousness work? Us humans, I mean. And I'm not talking about some new-age hocus-pocus, I'm talking about the sum of the knowledge compiled by disciplined scientists over three hundred years through arduous experiments and skeptic vetting of theories. I'm talking about the insights you gain by actually poking around inside people's heads, studying human behavior, and conducting experiments to figure out the truth, and separating that from all the bullshit about the brain and consciousness that has no basis in reality whatsoever. I'm talking about the understanding of the brain that has resulted in things like neuronic warfare, the neurographic network, and Sentre Stimulus TLEs. How much do you really know about that? I suppose you still have the typical twentieth-century view of the whole thing. The self is situated in the brain somehow, like a small pilot in a cockpit behind your eyes. You believe that it is a mix of memories and emotions and things that make you cry, and all that is probably also inside your brain, because it would be strange if that were inside your heart, which you've been taught is a muscle. But at the same time you're having trouble reconciling with the fact that all that is you, all your thoughts and experiences and knowledge and taste and opinions, should exist inside your cranium. So you tend not to dwell on such questions, thinking “There's probably more to it” and being satisfied with a fuzzy image of a gaseous, transparent Something floating around in an undefined void. Maybe you don't even put it into words, but we both know that you're thinking about an archetypical soul. You believe in an invisible ghost.

Take, for example, the following sentence: “I prefer to eat with a fork and a camel.” Your brain has just generated an N400 wave, an error signal evoked by a word or an image which is incompatible with the preceding context.11 As its name suggests, this is a negative response that occurs at about four hundred milliseconds after the anomaly and arises from neuronal populations of the left temporal cortex that are sensitive to word meaning. On the other hand, Broca’s area in the inferior prefrontal cortex reacts to errors of syntax, when the brain predicts a certain category of word and receives another,12 as in the following sentence: “Don’t hesitate to take your whenever medication you feel sick.” This time, just after the unexpected word “whenever,” the areas of your brain that specialize in syntax emitted a negative wave immediately followed by a P600 wave—a positive peak that occurs around six hundred milliseconds. This response indicates that your brain detected a grammar error and is trying to repair it.

Positive arguments for the natural possibility of absent qualia have not been as prevalent as arguments for inverted qualia, but they have been made. The most detailed presentation of these arguments is given by Block (1978). These arguments almost always have the same form. They consist in the exhibition of a realization of our functional organization in some unusual medium, combined with an appeal to intuition. It is pointed out, for example, that the organization of our brain might be simulated by the people of China or even mirrored in the economy of Bolivia. If we got every person in China to simulate a neuron (we would need to multiply the population by ten or one hundred, but no matter), and equipped them with radio links to simulate synaptic connections, then the functional organization would be there. But surely, says the argument, this baroque system would not be conscious! There is a certain intuitive force to this argument. Many people have a strong feeling that a system like this is simply the wrong sort of thing to have a conscious experience. Such a “group mind” would seem to be the stuff of a science-fiction tale, rather than the kind of thing that could really exist. But there is only an intuitive force. This certainly falls far short of a knockdown argument. Many have pointed out that while it may be intuitively implausible that such a system should give rise to experience, it is equally intuitively implausible that a brain should give rise to experience! Whoever would have thought that this hunk of gray matter would be the sort of thing that could produce vivid subjective experiences? And yet it does. Of course this does not show that a nation's population could produce a mind, but it is a strong counter to the intuitive argument that it would not. . . . Once we realize how tightly a specification of functional organization constrains the structure of a system, it becomes less implausible that even the population of China could support conscious experience if organized appropriately. If we take our image of the population, speed it up by a factor of a million or so, and shrink it into an area the size of a head, we are left with something that looks a lot like a brain, except that it has homunculi—tiny people—where a brain would have neurons. On the face of it, there is not much reason to suppose that neurons should do any better a job than homunculi in supporting experience.

To give you a sense of the sheer volume of unprocessed information that comes up the spinal cord into the thalamus, let’s consider just one aspect: vision, since many of our memories are encoded this way. There are roughly 130 million cells in the eye’s retina, called cones and rods; they process and record 100 million bits of information from the landscape at any time. This vast amount of data is then collected and sent down the optic nerve, which transports 9 million bits of information per second, and on to the thalamus. From there, the information reaches the occipital lobe, at the very back of the brain. This visual cortex, in turn, begins the arduous process of analyzing this mountain of data. The visual cortex consists of several patches at the back of the brain, each of which is designed for a specific task. They are labeled V1 to V8. Remarkably, the area called V1 is like a screen; it actually creates a pattern on the back of your brain very similar in shape and form to the original image. This image bears a striking resemblance to the original, except that the very center of your eye, the fovea, occupies a much larger area in V1 (since the fovea has the highest concentration of neurons). The image cast on V1 is therefore not a perfect replica of the landscape but is distorted, with the central region of the image taking up most of the space. Besides V1, other areas of the occipital lobe process different aspects of the image, including: •  Stereo vision. These neurons compare the images coming in from each eye. This is done in area V2. •  Distance. These neurons calculate the distance to an object, using shadows and other information from both eyes. This is done in area V3. •  Colors are processed in area V4. •  Motion. Different circuits can pick out different classes of motion, including straight-line, spiral, and expanding motion. This is done in area V5. More than thirty different neural circuits involved with vision have been identified, but there are probably many more. From the occipital lobe, the information is sent to the prefrontal cortex, where you finally “see” the image and form your short-term memory. The information is then sent to the hippocampus, which processes it and stores it for up to twenty-four hours. The memory is then chopped up and scattered among the various cortices. The point here is that vision, which we think happens effortlessly, requires billions of neurons firing in sequence, transmitting millions of bits of information per second. And remember that we have signals from five sense organs, plus emotions associated with each image. All this information is processed by the hippocampus to create a simple memory of an image. At present, no machine can match the sophistication of this process, so replicating it presents an enormous challenge for scientists who want to create an artificial hippocampus for the human brain.

Recently, brain scans of schizophrenics taken while they were having auditory hallucinations have helped explain this ancient disorder. For example, when we silently talk to ourselves, certain parts of the brain light up on an MRI scan, especially in the temporal lobe (such as in Wernicke’s area). When a schizophrenic hears voices, the very same areas of the brain light up. The brain works hard to construct a consistent narrative, so schizophrenics try to make sense of these unauthorized voices, believing they originate from strange sources, such as Martians secretly beaming thoughts into their brains. Dr. Michael Sweeney of Ohio State writes, “Neurons wired for the sensation of sound fire on their own, like gas-soaked rags igniting spontaneously in a hot, dark garage. In the absence of sights and sounds in the surrounding environment, the schizophrenic’s brain creates a powerful illusion of reality.” Notably, these voices seem to be coming from a third party, who often gives the subject commands, which are mostly mundane but sometimes violent. Meanwhile, the simulation centers in the prefrontal cortex seem to be on automatic pilot, so in a way it’s as though the consciousness of a schizophrenic is running the same sort of simulations we all do, except they’re done without his permission. The person is literally talking to himself without his knowledge. HALLUCINATIONS The mind constantly generates hallucinations of its own, but for the most part they are easily controlled. We see images that don’t exist or hear spurious sounds, for example, so the anterior cingulate cortex is vital to distinguish the real from the manufactured. This part of the brain helps us distinguish between stimuli that are external and those that are internally generated by the mind itself. However, in schizophrenics, it is believed that this system is damaged, so that the person cannot distinguish real from imaginary voices. (The anterior cingulate cortex is vital because it lies in a strategic place, between the prefrontal cortex and the limbic system. The link between these two areas is one of the most important in the brain, since one area governs rational thinking, and the other emotions.) Hallucinations, to some extent, can be created on demand. Hallucinations occur naturally if you place someone in a pitch-black room, an isolation chamber, or a creepy environment with strange noises. These are examples of “our eyes playing tricks on us.” Actually, the brain is tricking itself, internally creating false images, trying to make sense of the world and identify threats. This effect is called “pareidolia.” Every time we look at clouds in the sky, we see images of animals, people, or our favorite cartoon characters. We have no choice. It is hardwired into our brains. In a sense, all images we see, both real and virtual, are hallucinations, because the brain is constantly creating false images to “fill in the gaps.” As we’ve seen, even real images are partly manufactured. But in the mentally ill, regions of the brain such as the anterior cingulate cortex are perhaps damaged, so the brain confuses reality and fantasy.

We are conscious of only a tiny fraction of the information that our brains process in each moment.1 Although we continually notice changes in our experience—in thought, mood, perception, behavior, etc.—we are utterly unaware of the neurophysiological events that produce them. In fact, we can be very poor witnesses to experience itself. By merely glancing at your face or listening to your tone of voice, others are often more aware of your state of mind and motivations than you are. I generally start each day with a cup of coffee or tea—sometimes two. This morning, it was coffee (two). Why not tea? I am in no position to know. I wanted coffee more than I wanted tea today, and I was free to have what I wanted. Did I consciously choose coffee over tea? No. The choice was made for me by events in my brain that I, as the conscious witness of my thoughts and actions, could not inspect or influence. Could I have “changed my mind” and switched to tea before the coffee drinker in me could get his bearings? Yes, but this impulse would also have been the product of unconscious causes. Why didn’t it arise this morning? Why might it arise in the future? I cannot know. The intention to do one thing and not another does not originate in consciousness—rather, it appears in consciousness, as does any thought or impulse that might oppose it. The physiologist Benjamin Libet famously used EEG to show that activity in the brain’s motor cortex can be detected some 300 milliseconds before a person feels that he has decided to move.2 Another lab extended this work using functional magnetic resonance imaging (fMRI): Subjects were asked to press one of two buttons while watching a “clock” composed of a random sequence of letters appearing on a screen. They reported which letter was visible at the moment they decided to press one button or the other. The experimenters found two brain regions that contained information about which button subjects would press a full 7 to 10 seconds before the decision was consciously made.3 More recently, direct recordings from the cortex showed that the activity of merely 256 neurons was sufficient to predict with 80 percent accuracy a person’s decision to move 700 milliseconds before he became aware of it.4 These findings are difficult to reconcile with the sense that we are the conscious authors of our actions. One fact now seems indisputable: Some moments before you are aware of what you will do next—a time in which you subjectively appear to have complete freedom to behave however you please—your brain has already determined what you will do. You then become conscious of this “decision” and believe that you are in the process of making it. The distinction between “higher” and “lower” systems in the brain offers no relief: I, as the conscious witness of my experience, no more initiate events in my prefrontal cortex than I cause my heart to beat. There will always be some delay between the first neurophysiological events that kindle my next conscious thought and the thought itself. And even if there weren’t—even if all mental states were truly coincident with their underlying brain states—I cannot decide what I will next think or intend until a thought or intention arises. What will my next mental state be? I do not know—it just happens. Where is the freedom in that?

In the artifacts that are conscious, memories of vanished lives still flicker. Tissues that were changed without dying hold the moment that a boy heard his sister was leaving home. They hold multiplication tables. They hold images of sexuality and violence and beauty. They hold the memories of flesh that no longer exists. They hold metaphors: mitochondria, starfish, Hitler’s-brain-in-a-jar, hell realm. They dream. Structures that were neurons twitch and loop and burn and dream.

For example, the visual cortex would engage layers and layers of neurons to turn pixels of retinal stimulation into recognizable images before it can scream to the amygdala, “It’s a gun!” Importantly, some sensory information entering the brain takes a shortcut, bypassing the cortex and going directly to the amygdala. Thus the amygdala can be informed about something scary before the cortex has a clue.

Plaster holo screens against a mountain a full kilometer high, covering it until it glitters with a half million dancing images. Each holo used a quarter of a million pixels to shape its image, so the array musters immense representational power. Now compress those screens on a sheet of aluminum foil a millimeter thick. Crumple it. Stuff it into a grapefruit. That is the brain, a hundred billion neurons firing at varying intensities. Nature had accomplished that miracle,

A whole new way of thinking seemed to ray out from Zeki’s work, and it set me thinking of the possible neural basis for consciousness in a way I had never considered before—and to realize that with our new powers of imaging the brain and our newly developed abilities to record the activity of individual neurons in living and conscious brains, we might be able to plot how and where all sorts of experiences are “constructed.” This was an exhilarating thought. I realized the vast leap which neurophysiology had made since my own student days in the early 1950s, when it was beyond our power, almost beyond imagination, to record from individual nerve cells in the brain while an animal was conscious, perceiving, and acting. —

In the artifacts that are conscious, memories of vanished lives still flicker. Tissues that were changed without dying hold the moment that a boy heard his sister was leaving home. They hold multiplication tables. They hold images of sexuality and violence and beauty. They hold the memories of flesh that no longer exists. They hold metaphors: mitochondria, starfish, Hitler’s-brain-in-a-jar, hell realm. They dream. Structures that were neurons twitch and loop and burn and dream. Images and words and pain and fear, endless.

A half century after Nidetch’s Mallomar binges, scientists had developed a technology that could see cravings erupting, like solar flares, inside the human brain. In early 2008, a research team at the Lewis Center for Neuroimaging at the University of Oregon measured just such a craving in a nineteen-year-old college student we will call Debbie. Debbie had her head inside a very large, very expensive round magnet called an MRI scanner when an image of a chocolate milk shake was flashed before her eyes for two seconds. As soon as Debbie saw it, certain parts of her brain became “activated,” which is to say they drew in lots of blood as millions of neurons were fired. These regions—the left medial orbitofrontal cortex, anterior cingulate cortex, and three other small, curly pockets of gray matter—are all associated with “motivation.” And the functional MRI (fMRI) showed them glowing a bright yellowy orange, like coals in a hot fire, indicating those parts of her brain were churning through quite a lot of blood. She was experiencing “incentive salience,” the scientific term for a Frankenstein craving, or a heightened state of “wanting.” Debbie got what she wanted.

Figure 2.1 Cortical connections over two years adapted from Conel The top row shows the baby’s cortex at birth, then at one month and at three months. They all look about the same, don’t they? But look what happens at six months (bottom left box): the number of cell bodies remains the same, but the number of connections has multiplied exponentially. The connections grow so quickly in the first three years of life that neuroscientists call it neural exuberance. Neural exuberance! The name is well earned: The baby’s brain makes 24 million new connections every minute, and this continues for the first three years of life. Each neuron may be connected to 1,000 other neurons — that multiplies out to 100 trillion possible connections between neurons, more than the number of stars in the universe. This high level of connectivity between brain cells leads to the cortex of a three-year-old being twice as thick as an adult’s! As connections are created, new abilities emerge. For example, when connections grow in Broca’s area — speech production — around six months, then children begin to speak. Around nine months of age, the frontal areas (behind the forehead) become more interconnected, and that’s when most children develop object permanence: knowing that objects continue to exist even when they are out of sight. Before object permanence develops, when Mom is out of sight she’s no longer in the baby’s universe. This is why young babies are inconsolable when Mom leaves. Once they start to develop object permanence, babies can hold on to an internal image of Mom. This is about the age that babies play peek-a-boo. Mom disappears when she puts the blanket over her head, but the nine-month-old knows Mom’s still there even if he can’t see her. The infant tests his “knowledge” when he pulls the blanket off and sees — sure enough! —Mom really is there! What is the use of so many brain connections in the first three years of life? These connections are ready-made highways for information to travel along. The toddlers’ ability to quickly adapt and learn is possible because they have a vast number of brain connections available for making sense of the world. Thanks to neural exuberance, the child does not need to create connections on the spur of the moment to make meaning of each new experience; myriad connections are already there. Pruning of connections The number of connections remains high from age 3 until age 10, when the process of neural pruning begins. Connections that are being used remain; others get absorbed back into the neuron. It’s similar to pruning a bush. After pruning, individual branches get thicker, fruit is more abundant, and the whole bush gets fuller. This seems a little counter-intuitive, but pruning works because it allows the plant’s limited resources to go to its strongest parts; water and nutrients are no longer wasted on spindly branches and dried-out roots. Similarly, when unused brain connections are pruned, neural resources are more available for brain areas that are being used. This results in a more useful and efficient brain that’s tailor-made to meet each individual’s needs. This process of pruning occurs in all brain areas. Figure 2.2 presents findings published by Sowell and associates. They measured Magnetic Resonance Imaging in 176 normal subjects from age 7 to 87 years. The x-axes in these graphs present years from 10 to 90 years. Notice there is a common pattern of decreasing connections in all brain areas. In some brain areas this change is steeper, such as in frontal areas, but is flatter in other areas such as temporal areas in the left hemisphere.

Rate of myelination in different brain areas The various brain areas begin and end myelination at different ages. For example, visual areas finish myelinating by six months. At that age an infant can see an object moving through space as a homogeneous object; before that, it’s just a collection of disconnected colors and edges. Watch babies wave a toy back and forth in front of their eyes. This rehearsal wires up the visual areas so they can begin to recognize and track objects. Over and over, the same groups of neurons fire together, forming visual functional groups that eventually work together well enough to let the baby recognize familiar objects. Babies’ other senses work along with sight to help form a mental image of objects. Here’s one study that continues to astonish me every time I think about it: Newborns, still in the hospital, were given pacifiers to suck. There were several different shapes: square, round, pointed. Large models of all the different-shaped pacifiers were hung above their cribs. The babies stared longest at the pacifier that matched the one that had been in their mouth. These infants appeared able to relate the mental image created with touch — what was in their mouths — with the one created with vision — what was dangling above their heads. I remember the first time our oldest daughter saw a book. She was about three months old — barely able to sit up — and we put a cardboard book with very simple pictures of toys in front of her. Instantly she put her face right above the book, and she inspected every square inch of the page from about an inch away. Then she sat back up and slapped the pages all over. We could almost see her brain working: “What is this? It’s flat but it reminds me a lot of the things I see around me.” She combined the senses of touch and sight together to examine a new phenomenon in her world. Speech begins with babbling at around six months of age. I remember our youngest daughter beginning speech by mimicking the up and down flow of the sentence before she began to make individual sounds. The flow of speech is supported by language centers in the right hemisphere; the details of speech are supported by language centers in the left hemisphere. Our daughter was practicing how to talk, using the brain areas that were currently available. Her right hemisphere appeared to mature before her left hemisphere. As the speech areas develop and these groups become more extensively coordinated, the child’s speech becomes clearer and connected. The auditory areas finish myelinating by two years. The child now has the brain foundation for speech production. She can distinguish the individual sounds that make up words, and can begin to string words together into phrases and sentences. The motor system is myelinated by four years. Before that, children are very slow to respond. Have you ever played catch with a three-year-old? He holds out his arms, the ball hits his chest, it falls on the ground — and then he closes his arms. It takes so long for the message to move from his eyes to his brain, from his brain to the spinal cord, and finally from his spinal cord to his arms, that he misses the ball. You can practice with him all you like, but his reactions won’t speed up until his motor system myelinates.

Here’s a research study that shows just how differently teens’ brains function: In a Magnetic Resonance Imaging (MRI) study, teenagers and adults were presented pictures of people who looked scared or anxious. The adults recognized the fear in the faces but placed the experiences in a larger context, so it didn’t affect them personally. The opposite was true of the teens: they did not report that the faces were fearful, but they became emotionally involved and reported more fear and anxiety themselves. In teens, the parts of the brain that process gut reactions and primitive emotions — the amygdala and insula — were active. But in adults, the frontal lobes were activated as well. In other words, the teenagers’ brains responded emotionally. They felt upset but their brains did not identify the source of those feelings. The adults’ brains added reason to that response. Remember this when your teen gets upset “for no reason.” He may not be able to say why he’s feeling that way, but his feelings are still valid. He doesn’t have the connections between his rational brain and his emotional brain that would allow him to explain it. Logic doesn’t help because the teen’s brain cannot follow abstract logic. They are doing the best they can with the brain connections they have. This is especially true if your teen is a boy. As we see later, girls have more connections between their emotional and executive centers. Astrocytes: Functional and structural support Astrocytes are another class of glial cells. They are star-shaped, hence their name, and provide structural and functional support for the neuron. Astrocytes form the matrix that keeps neurons in place. But they are more than inert bricks in a passive wall. Rather, they function more like the mother who ensures her children have brushed their teeth, are wearing their coats in winter, and are eating good meals. An astrocyte is pictured in Figure 3.3. Astrocytes sit between blood vessels and neurons and breakdown glucose from the capillaries into lactic acid, which the mitochondria of the neurons use for energy. As a wise mother, they do not break down all of the glycogen they receive from the blood, but create a reserve for times when the metabolic need of neurons are especially high.

Figure 3.3 Astrocytes maintain the structure of the synapses. In addition, the astrocytes maintain the 20 nanometer wide space between the axon terminal from one cell (output) and the dendritic spines of another cell (input). This space is called the synapse. How is this very thin space maintained? Why doesn’t the axon terminal float away? Or glide into the dendritic spine? Notice in the figure the ends of the astrocyte envelop the synapse and maintain its integrity. The astrocyte both encircles the axon terminal and the dendritic spine and maintains the optimal distance between them. (We discuss the dynamics within the synapse later.) This serves to isolate the synapse from the space around the neuron, and so limits the dispersion of transmitter substances released by the axon terminal into the extracellular space. Children are not just small adults Now you can understand why children are not just small adults. Children’s brain connections are different than adults, and so children necessarily process the world in a different way than their parents. Figure 3.4 below shows brain images (heads are facing to the left) when children and adults were given the same task — a “noun/verb” task. They heard a noun, such as car, and generated a verb. What verb might you generate for the word car? Drive. For the word bike? Ride. For the word food? Eat. Notice, children perform this task by primarily using the back of the brain (right of the figure). This is the visual association area, the area that creates concrete perception. When adults did this task, the most active parts of the brain were in the front (right of the figure).

Pulsed lasers produce incredibly short bursts of electromagnetic energy. For example, a pulsed femtosecond laser produces a flash of light that lasts for femtoseconds to a picosecond (a picosecond is one trillionth of a second, a femtosecond is one thousandth of a picosecond), instantly followed by another (and so on). These lasers brought about the possibility of exciting fluorophores with two photons of only half the necessary energy, but they need to arrive almost simultaneously to generate the ejection of a photon. Infrared pulsed lasers penetrate living tissue more effectively, with the advantage that fluorescence is achieved from much deeper in the tissue than normal fluorescence, where the depth of penetration is limited by multiple light scattering events. Multiphoton microscopy (mainly two photon in practice, but also feasible as three or more photons) allows imaging from as deep as a millimetre (one thousand micrometres), an improvement of several hundred micrometres over fluorescence confocal microscopy. A second advantage of two photon excitation is that it forms as a single spot in the axial plane (z axis) without the ‘hourglass’ spread of out of focus light (the point spread function) that happens with single photon excitation. This is because the actual two photon excitation will only occur at the highest concentration of photons, which is limited to the focal plane itself. Because there is no out of focus light, there is no need for a confocal pinhole, allowing more signal to reach the detector. Combined with the increased depth of penetration, and reduced light induced damage (phototoxicity) to living tissue, two photon microscopy has added a new dimension to the imaging of living tissue in whole animals. At the surface of a living brain, remarkable images of the paths of whole neurons over several hundred micrometres can be reconstructed as a 3D z section from an image stack imaged through a thinned area of the skull in an experimental animal. Endoscopes have been developed which incorporate a miniaturized two photon microscope, allowing deep imaging of intestinal epithelium, with potential to provide new information on intestinal diseases, as most of the cellular lining throughout our gut is thin enough to be imaged in this way. So far a whole range of conditions including virtually all the cancers of the digestive tract as well as inflammatory bowel disease have been investigated, reducing the need for biopsies and providing new insights as to the nature of these conditions.

When we are around people as well as images, we began taking on their moods and emotions. Resonance is the driving force that makes this transference of energy and information happen. On a biological level, mirror neurons are part of the physical mechanism that causes us to emulate the images around us.

The dance between sun and clouds, the discourse between meadow and flowers, I knew, and even the imagined sonata of stream and bird had touched a memory too drowsy to rise to consciousness. A memory the shade of night almost resurfaced upon my mind; the sensation of breeze almost linked to the isolated neuron clusters. I embraced that nausea and tried to nourish it, hoping it would mature into a newborn image, an episode in my personal history, a defining symbol of my self. If only I could reach deeper into that emotion, link the neurons between my amygdala and my prefrontal cortex, I might touch my forgotten self.

There were brain-imaging studies that suggested there was overactivity in the anterior cingulate gyrus in patients who had obsessive compulsive disorder (OCD). There was a SPECT study in 1991 reporting that Prozac decreased activity in the anterior cingulate gyrus in OCD patients. I saw hyperactivity in the anterior cingulate gyrus in many patients who did not have OCD. But I noticed a common thread with OCD. Patients had trouble shifting attention. Researcher Alan Mirsky wrote a book chapter highlighting the anterior cingulate area of the brain as being involved with shifting attention. In Robbin, Kaitlyn, and many of my patients who had too much activity in the anterior cingulate gyrus I saw this problem of shifting attention: there was a certain cognitive inflexibility that was evident in many of their symptoms. Could it be possible that oppositional children had a similar underlying brain mechanism found in OCD? I was intrigued. Over time the finding proved to be true. When there is increased activity in the anterior cingulate gyrus a certain cognitive inflexibility is present. This can present as many different symptoms, but the underlying mechanism, trouble shifting attention, remains. The symptom list at the beginning of the chapter is a compilation of what we have seen in these patients. The anterior cingulate area of the brain is heavily innervated with serotonin neurons. We have also found that serotonergic medications seem to be the most helpful in this disorder. The Anterior Cingulate Gyrus

There is a reason our schools and offices are plastered with whiteboards. We acquire more information through vision than through all the other senses combined.1 Of the 100 billion neurons in our brains, approximately 20% are devoted to analyzing visual information.2 The visual-spatial learner thinks primarily in images. A study done by psychologist and founder of the Institute for the Study of Advanced Development, Linda Kreger Silverman, suggests that two-thirds of the population have a visual-spatial preference.3 The left hemisphere is sequential, analytical, and time-oriented. The right hemisphere perceives the whole, synthesizes, and apprehends movement in space. For visual-spatial learners, if the right hemisphere is not activated and engaged, then attention will be low and learning will be poor.

At several hundred dollars instead of a few thousand, retinal imaging is much less expensive than amyloid PET scans of the brain. It also identifies much smaller plaques, which may be more accurate sentinels of treatment effects, and also has the potential to reveal whether the amyloid affects the retina’s blood vessels (and by extension, likely the brain’s as well) in addition to the neurons and synapses themselves. This

So the steps in 3-2-1 are: Find it, Face it, Talk to it, Be it. Step One: Find It. Locate the symptom, pressure, pain, image, person, or thing that seems to be the core of the problem—the fear, anxiety, depression, obsession, jealousy, envy, anger. Locate it, and notice everything about it—the symptoms themselves (the uncomfortable feelings generated by the problematic person, place, or event). Notice its location in your body (for example, head, eyes, chest, breasts, arms, shoulders, stomach, gut, genitals, thighs, lower legs, feet, toes, perhaps single muscles or muscle groups, sometimes bodily organ systems—digestive, urinary, reproductive, respiratory, circulatory, neuronal). Notice its general size, color, shape, smell, texture (whatever comes to mind when you think any of those elements). Notice what seems to most trigger it, what seems to soothe it, and activities that often accompany it (for example, increased heart rate, increased breathing, particular muscle tightening, headaches, difficulty swallowing, sexual inadequacy or disinterest). Don’t judge them as good or bad, positive or negative. Just pretend that you are videotaping them, taking pictures of them, exactly as they are, not as you want or wish them to be—you are aiming for just a simple, comprehensive mindfulness of them. Get a lot of plain neutral videotape on every aspect of the problem. Get it fully in your awareness as an object.

ADHD brain: being flooded by momentary emotions; delays in brain maturation; imaging studies on reward-recognizing circuits of the; imaging studies showing abnormalities in white matter in; immediate or delayed “payoffs” in the; impaired neurotransmitters and neuron networks in the; set of interacting impairments of executive functions in; structural and chemical impairments that underlie ADHD. See also Brain; Executive functions (EFs)

As idols of God, as image bearers, we are connected to the presence of God. God is with us. When we are connected with God, our mirror neurons are attuned to God—attuned to what he is thinking and feeling about us, others, and the world. Through this attunement with God, we bear his presence to everything in the world.

The operations of interior organs and systems are gradually represented in the nervous system, first in its peripheral nerve components, then in nuclei of the central nervous system (in the brain stem, for example), and later in the cerebral cortex. But there is an intense cooperation between body parts and neural elements. Body and nervous system remain interactive partners rather than separate “model” and “depiction.” What is ultimately imaged is neither purely neural nor purely bodily. It emerges from a dialogue, from a dynamic give-and-take between body chemistry and the bioelectrical activity of neurons.