Nc Quotes

We've searched our database for all the quotes and captions related to Nc. Here they are! All 100 of them:

NC passed law against global warming science, therefore it's not happening. So I'm ignoring Twitter's 140-character limit, so it's not happ
Stephen Colbert
Optimism was for children. Once you reached adulthood then you had to join the rest of the world as a realist - life was a bag of shit you were expected to pay for.
NikNak (Brand (The Book of The Fallen, #1))
I like misty autumn mornings, and cold snowy winter nights. Rainstorms bring me innerpeace, thunder sets my soul alight. I care not for summer, days too long, the heavy heat. Give me candlelight evenings, early darkness, a silent street.
N.C.
Ain’t no kinda real man in that crowd. If they’re holdin’ a gun, we shoot’em. If they’re hurtin’ anybody, we shoot’em. If they’re stealin’, we shoot’em. If they threaten any women or kids, we shoot’em. If they’re still alive, we shoot’em again. That ‘bout covers it, don’t it?
N.C. Reed (Odd Billy Todd)
Like every other tiny-ass town in the South, there were plenty of crappy Mexican restaurants to choose from. Not fancy Mexican like I eat in L.A. When I eat Mexican food in L.A., it’s like a kale salad with pepitas and soy beef tacos with fresh pico de gallo. In NC, it’s a five-dollar plate of cheese enchiladas with refried beans and a bowl of melted white cheese dip. Essentially you just walk in and ask for a plate of brown with a little iceberg lettuce, and it’s fucking delish.
Mamrie Hart (You Deserve a Drink: Boozy Misadventures and Tales of Debauchery)
Dear Daniel, How do you break up with your boyfriend in a way that tells him, "I don't want to sleep with you on a regular basis anymore, but please be available for late night booty calls if I run out of other options"? Lily Charlotte, NC Dear Lily, The story's so old you can't tell it anymore without everyone groaning, even your oldest friends with the last of their drinks shivering around the ice in their dirty glasses. The music playing is the same album everyone has. Those shoes, everybody has the same shoes on. It looked a little like rain so on person brought an umbrella, useless now in the starstruck clouded sky, forgotten on the way home, which is how the umbrella ended up in her place anyway. Everyone gets older on nights like this. And still it's a fresh slap in the face of everything you had going, that precarious shelf in the shallow closet that will certainly, certainly fall someday. Photographs slipping into a crack to be found by the next tenant, that one squinter third from the left laughing at something your roommate said, the coaster from that place in the city you used to live in, gone now. A letter that seemed important for reasons you can't remember, throw it out, the entry in the address book you won't erase but won't keep when you get a new phone, let it pass and don't worry about it. You don't think about them; "I haven't thought about them in forever," you would say if anybody brought it up, and nobody does." You think about them all the time. Close the book but forget to turn off the light, just sit staring in bed until you blink and you're out of it, some noise on the other side of the wall reminding you you're still here. That's it, that's everything. There's no statue in the town square with an inscription with words to live by. The actor got slapped this morning by someone she loved, slapped right across the face, but there's no trace of it on any channel no matter how late you watch. How many people--really, count them up--know where you are? How many will look after you when you don't show up? The churches and train stations are creaky and the street signs, the menus, the writing on the wall, it all feels like the wrong language. Nobody, nobody knows what you're thinking of when you lean your head against the wall. Put a sweater on when you get cold. Remind yourself, this is the night, because it is. You're free to sing what you want as you walk there, the trees rustling spookily and certainly and quietly and inimitably. Whatever shoes you want, fuck it, you're comfortable. Don't trust anyone's directions. Write what you might forget on the back of your hand, and slam down the cheap stuff and never mind the bad music from the window three floors up or what the boys shouted from the car nine years ago that keeps rattling around in your head, because you're here, you are, for the warmth of someone's wrists where the sleeve stops and the glove doesn't quite begin, and the slant of the voice on the punch line of the joke and the reflection of the moon in the water on the street as you stand still for a moment and gather your courage and take a breath before stealing away through the door. Look at it there. Take a good look. It looks like rain. Love, Daniel Handler
Daniel Handler
NC: You’re right, but I think it tells you something very interesting about Western culture. When they went to the concentration camps and were appalled, they did not say, “Let’s save the survivors”; they said, “Let someone else pay for saving the survivors.” IP: Exactly.
Noam Chomsky (On Palestine)
Dear Patton: I've been feeling blue lately but I wasn't sure if it had anything to do with the amount of rain we've had over the last few weeks. What are your thoughts on that? Ms. Diller Cary, NC Dear Ms. Diller: Rain can have a profound effect on someone inclined toward melancholy. I live in Los Angeles, and, as of this writing, we've just experienced three weeks of unending late-winter storms. The sky has been a limitless bowl of sludgy, hopeless gray. The ground, soaked and muddy, emits burbly, hissing spurts with every step, which sound like a scornful parent who sees no worth, hope, or value in their offspring. The morning light through my bedroom window promises nothing but a damp, unwelcoming day of thankless busywork and futile, doomed chores. My breakfast cereal tastes like being ostracized. My morning coffee fills my stomach with dread. What's the point of even answering this question? The rain--it will not stop. Even if I say something that will help you--which I won't, because I'm such a useless piece of shit--you'll eventually die and I'll die and everyone we know will die and this book will turn to dust and the universe will run down and stop, and dead dead dead dead dead. Dead. Read Chicken Soup for the Soul, I guess. Dead. Dead dead. Patton
Patton Oswalt
It was hard to get ahead when your energy and time were dedicated to keeping a roof over your head and the utilities on.
Grace Greene (Beach Rental (Emerald Isle, NC #1))
Sand might shift with wind or tide, but it didn’t really change, it just rearranged itself.
Grace Greene (Beach Towel (Emerald Isle, NC #1.5))
Remember, to embody Active Patience, we must be in it for the long term.
N.C Harley (Active Patience: A Simple Guide to Productive Writing)
The Energy of the mind is the essence of life
N.C Harley (Active Patience: A Simple Guide to Productive Writing)
The Concept of Gender Does Not Exist....All There Is, Is What Is
Andrea Bird (founder of The X & Y Foundation of NC, Inc)
The on-screen depiction of oral sex performed on women has consistently earned movies an NC-17 rating – Blue Valentine, Boys Don’t Cry, and Charlie Countryman are a few that come to mind. The same standard has certainly not been applied to on-screen blow jobs. I often think of 2013s Lovelace, a biopic about the star of the 1972 porn film Deep Throat. This was an entire movie dedicated to fellatio, and to extreme sexual violence, and even that was given a mild R. Sure, let the kids watch a porn star get repeatedly raped, but female desire? No, no, no.
Amanda Montell (Wordslut: A Feminist Guide to Taking Back the English Language)
For anything worth having one must pay the price; and the price is always work, patience, love, self-sacrifice. No paper currency, no promises to pay, but the gold of real service.” - John Burroughs, Naturalist and Essayist 
N.C Harley (Active Patience: A Simple Guide to Productive Writing)
From the line, watching, three things are striking: (a) what on TV is a brisk crack is here a whooming roar that apparently is what a shotgun really sounds like; (b) trapshooting looks comparatively easy, because now the stocky older guy who's replaced the trim bearded guy at the rail is also blowing these little fluorescent plates away one after the other, so that a steady rain of lumpy orange crud is falling into the Nadir's wake; (c) a clay pigeon, when shot, undergoes a frighteningly familiar-looking midflight peripeteia -- erupting material, changing vector, and plummeting seaward in a corkscrewy way that all eerily recalls footage of the 1986 Challenger disaster. All the shooters who precede me seem to fire with a kind of casual scorn, and all get eight out of ten or above. But it turns out that, of these six guys, three have military-combat backgrounds, another two are L. L. Bean-model-type brothers who spend weeks every year hunting various fast-flying species with their "Papa" in southern Canada, and the last has got not only his own earmuffs, plus his own shotgun in a special crushed-velvet-lined case, but also his own trapshooting range in his backyard (31) in North Carolina. When it's finally my turn, the earmuffs they give me have somebody else's ear-oil on them and don't fit my head very well. The gun itself is shockingly heavy and stinks of what I'm told is cordite, small pubic spirals of which are still exiting the barrel from the Korea-vet who preceded me and is tied for first with 10/10. The two brothers are the only entrants even near my age; both got scores of 9/10 and are now appraising me coolly from identical prep-school-slouch positions against the starboard rail. The Greek NCOs seem extremely bored. I am handed the heavy gun and told to "be bracing a hip" against the aft rail and then to place the stock of the weapon against, no, not the shoulder of my hold-the-gun arm but the shoulder of my pull-the-trigger arm. (My initial error in this latter regard results in a severely distorted aim that makes the Greek by the catapult do a rather neat drop-and-roll.) Let's not spend a lot of time drawing this whole incident out. Let me simply say that, yes, my own trapshooting score was noticeably lower than the other entrants' scores, then simply make a few disinterested observations for the benefit of any novice contemplating trapshooting from a 7NC Megaship, and then we'll move on: (1) A certain level of displayed ineptitude with a firearm will cause everyone who knows anything about firearms to converge on you all at the same time with cautions and advice and handy tips. (2) A lot of the advice in (1) boils down to exhortations to "lead" the launched pigeon, but nobody explains whether this means that the gun's barrel should move across the sky with the pigeon or should instead sort of lie in static ambush along some point in the pigeon's projected path. (3) Whatever a "hair trigger" is, a shotgun does not have one. (4) If you've never fired a gun before, the urge to close your eyes at the precise moment of concussion is, for all practical purposes, irresistible. (5) The well-known "kick" of a fired shotgun is no misnomer; it knocks you back several steps with your arms pinwheeling wildly for balance, which when you're holding a still-loaded gun results in mass screaming and ducking and then on the next shot a conspicuous thinning of the crowd in the 9-Aft gallery above. Finally, (6), know that an unshot discus's movement against the vast lapis lazuli dome of the open ocean's sky is sun-like -- i.e., orange and parabolic and right-to-left -- and that its disappearance into the sea is edge-first and splashless and sad.
David Foster Wallace (A Supposedly Fun Thing I'll Never Do Again: Essays and Arguments)
The more you exercise the more energy you have, the more energy you have the more clearly you think. Active Patience is calm. Exercise reduces panic and anxiety behaviour. This is the kind of behaviour that makes us feel we are in a hurry and trying to do a million different things at once.We become paralysed, and beat ourselves up for it.
N.C Harley (Active Patience: A Simple Guide to Productive Writing)
Every time I believed Rya owned all of me, she would teach me differently. She would find a part of me I didn’t know I had, and own that, too.
India R. Adams (Praying for Thunder (Royal Bastards MC: Wilmington, NC Chapter, #1))
I know you are there before I turn around. There's a shift in the air, the wind changes its direction ever so slightly, but just enough to make me aware
N.C. Marshall (See You Soon)
money can't buy you happiness. What it can do, however, is buy you lots of expensive and meaningless crap to help disguise how unhappy you actually are.
N.C. Marshall (See You Soon)
scientists have discovered that chromosomal DNA—the DNA responsible for transmitting physical traits, such as the color of our hair, eyes, and skin—surprisingly makes up less than 2 percent of our total DNA.14 The other 98 percent consists of what is called noncoding DNA (ncDNA), and is responsible for many of the emotional, behavioral, and personality traits we inherit.
Mark Wolynn (It Didn't Start with You: How Inherited Family Trauma Shapes Who We Are and How to End the Cycle)
I would find out later that Kylee Alons of North Carolina State University, who is a 31x All-American, was so uncomfortable at having to share a locker room with a naked male, she changed in a storage closet. Kylee, NC State’s most decorated swimmer of all time, admitted to being constantly on edge whenever she had to go to the locker room. Knowing Thomas could walk in at any given moment, she always had a towel and parka nearby.
Riley Gaines (Swimming Against the Current: Fighting for Common Sense in a World That’s Lost its Mind)
His sophomore Creative Writing class was as silent as a room full of teenagers could be, only whispering and shuffling a little as they tried to complete their papers. This wasn’t one of the “easy A” electives, and he usually got the kids who were serious about the idea of being better writers. Half of them just wanted to get better so they could improve their Pacific Rim hurt/comfort fanfic, but there was nothing wrong with that. Besides, one of them had let slip that a good portion of the class was posting on Archive of Our Own, and he’d spent a few nights with a beer in his hand, learning more about his students. He hadn’t read the NC-17 pieces—there were professional limits—and yet he felt he respected them more as writers because he’d seen what they were capable of when they weren’t being graded.
Seanan McGuire (Reflections (Indexing, #2))
More people continue to join the party, some familiar faces, and some new ones that I look forward to getting to know. I smile and wave as I spot Lucy through the crowd, where she stands outside Logan’s Tavern laughing. She’s joined by the two girls she met when we first arrived here that she now classes as her best friends. She’s recently completed her first year of an art course at college. Seems she has a real flair for it, and I've never seen her happier. Her watercolours of Ceaders Bay, which take pride of place on the walls of our new home, are nothing short of phenomenal. She has recently painted one to send as a house warming gift to my parents, who are now living up the coast from us in their beloved village of Pemblington
N.C. Marshall (See You Soon)
http://www.batteriesmall.com.au/hp-co... HP COMPAQ Business Notebook NC6400 Laptop Battery
Barry (TWO STANDARDS 1898 (Victorian fiction : Novels of faith and doubt))
Wherefore if any man is in Christ, he is a new creature: the old things are passed away; behold, they are become new.
Grace Greene (Beach Winds (Emerald Isle, NC #2))
I located a N.C. UFO researcher whose name was George Fawcett. After meeting with him, we organized a steering committee and started the N.C. chapter for MUFON in the late 80’s.
Nick Redfern (The Black Diary: M.I.B, Women in Black, Black-Eyed Children, and Dangerous Books)
Commented Nirad Chaudhuri very appropriately: “…In the Indian nationalist movement there was not only a total absence of positive and constructive ideas, but even of thinking. These shortcomings were to have their disastrous consequence in 1947… The intellectual poverty of the nationalist movement gradually became intellectual bankruptcy, but nobody perceived that because the hatred of the British rule left no room for rational ideas… Over the whole period with which I am dealing [1921-52] none of them [Gandhi, Nehru…] put forth a single idea about what was to follow British rule… What was even more astonishing, none of these leaders were qualified to put forward any positive idea because none of them had any worthwhile knowledge of Indian history, life, and culture…”{NC/31-2}
Rajnikant Puranik (Nehru's 97 Major Blunders)
I don’t think it’s an accident that 7NC Luxury Cruises appeal mostly to older people. I don’t mean decrepitly old, but I mean like age-50+ people, for whom their own mortality is something more than an abstraction. Most of the exposed bodies to be seen all over the daytime Nadir were in various stages of disintegration. And the ocean itself (which I found to be salty as hell, like sore-throat-soothing-gargle-grade salty, its spray so corrosive that one temple-hinge of my glasses is probably going to have to be replaced) turns out to be basically one enormous engine of decay. Seawater corrodes vessels with amazing speed—rusts them, exfoliates paint, strips varnish, dulls shine, coats ships’ hulls with barnacles and kelp-clumps and a vague ubiquitous nautical snot that seems like death incarnate.
David Foster Wallace (A Supposedly Fun Thing I'll Never Do Again: Essays and Arguments)
Yes, I understand it’s 5 AM...Millie Watkins from the Medlin Creek Times.
N.C. Lewis (Creek Crisis (Ollie Stratford Mystery #2))
OTHER GREAT TITLES by N.C. REED! Parno’s Company Parno’s Destiny Parno’s Gambit Stormcrow: Books 1 & 2 Odd Billy Todd Tammy and Ringo
N.C. Reed (Brotherhood of Fire (Fire from the Sky #2))
Jim Valvano and North Carolina State actually came close to beating Dean Smith and North Carolina both times the two teams faced each other during the regular season in 1980–81. Carolina won a pair of three-point games, but—naturally—that wasn’t the way Valvano told the story in the years that followed. The way Valvano told it, Carolina won both games in blowouts. He counted on the fact that most of his listeners wouldn’t remember the two games. “So, the second time we get blown out, an old State alumnus comes up to me and he says, ‘Coach, I know you’re a Yankee and you don’t understand about tradition down here, but we cannot be losing to the Tar Heels this way.’ “I say to him, ‘No, I do get it. I know all about the tradition down here and I promise you, next season we’re going to do a lot better against them.’ “He shakes his head and says, ‘Coach, you just don’t get it. If you lose to the Tar Heels here in Reynolds [Coliseum] next season, we’re going to kill your dog.’ “Okay, I’m just a little nervous now because the guy isn’t smiling even a little bit. But I say to him, ‘Look, I have to tell you, I don’t have a dog, but I hear you loud and clear.’ “He just nods and walks away. Next morning I go to the front door to get my newspaper, and when I open the door there’s a basket on my front step. I look under the blanket and there’s the cutest little puppy you’ve ever seen in your life. There’s a note attached to the puppy’s collar. It says, ‘Don’t get too attached.’ ” The story illustrated the intensity of the Triangle rivalries among N.C. State, North Carolina, and Duke.
John Feinstein
The John Locke Foundation also sponsored the North Carolina History Project, which aimed to reorient the state’s teaching of its history by providing online lesson plans for high school teachers that downplayed the roles of social movements and government while celebrating what it called the “personal creation of wealth.” In a similar vein, Republicans in the state senate passed a bill requiring North Carolina’s high school students to study conservative principles as part of American history in order to graduate in 2015. The bill stressed the “constitutional limitations on government power to tax and spend.” “It’s all part of Pope’s plan to build up more institutional support for his philosophy,” said Chris Fitzsimon, director of NC Policy Watch, a liberal watchdog group.
Jane Mayer (Dark Money: The Hidden History of the Billionaires Behind the Rise of the Radical Right)
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I'd read that drawing random shapes triggers the logical brain into action. I picked up a pencil and doodled in my journal.
N.C. Lewis (The Bagington Hall Mystery (Maggie Darling #1))
On November 4, while the votes were still being counted, Rick Perry, Trump’s former secretary of energy, wrote Meadows about his “AGRESSIVE STRATEGY.” “Why can’t the states of GA NC PENN and other R controlled state houses declare this is BS […] and just send their own electors to vote,” Perry mused. Perry sent the message to a group chat that included Meadows and two people who were still part of Trump’s cabinet at the time: Secretary of Housing and Urban Development Ben Carson and Secretary of Agriculture George Ervin “Sonny” Perdue III. “Interesting,” Carson wrote. Alternate electors were a central element of various plots to overturn Trump’s loss that were cooked up by his allies in the weeks after the election. There were basically five states that mattered in the 2020 presidential race: Arizona, Pennsylvania, Michigan, Georgia, and Wisconsin. The rest of the results were predictable. It was all coming down to the margin in those swing states. Of course, presidential elections aren’t technically decided in the states. They
Denver Riggleman (The Breach: The Untold Story of the Investigation into January 6th)
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Willow Dumpsters Mooresville NC
the same Celebrity Cruises brain trust responsible for the wildly seductive brochure has decided to make certain elements of pre-embarkation as difficult and unpleasant as possible in order to sharpen the favorable contrast between real life and the 7NC experience.
David Foster Wallace (A Supposedly Fun Thing I'll Never Do Again: Essays and Arguments)
N.C. Chatterjee, one of Savarkar’s close colleagues in the Mahasabha, vented his frustration in a letter to Moonje: The entire Hindu population is with Gandhiji and his movement and if anybody wants to oppose it, he will be absolutely finished and hounded out of public life. The unfortunate statement of Veer Savarkar [opposing Quit India] made our position rather difficult in Bengal. It is rather amusing to find that Mr. Jinnah wants the Mussalmans not to join the Congress movement and Mr. Savarkar wants the Hindus not to join the same. Even when the Congress movement has made a great stir and it shows that it has got thousands of adherents.
Vikram Sampath (Savarkar: A Contested Legacy, 1924-1966)
M.R.: In the humanities certain professors spend their time in effect teaching their Ph.D. thesis. N.C.: Anybody who teaches at age fifty what he was teaching at age twenty-five had better find another profession. If in twenty-five years nothing has happened which proves to you that your ideas were wrong, it means that you are not in a living field, or perhaps are part of a religious sect.
Noam Chomsky (On Language)
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Road Haugs Moving and Storage
Kaelyn Sexton works as a Certified Nurse Midwife at Catawba Women's Center in Hickory, NC, and has a doctorate, a master's degree, and two B.S. degrees in nursing-related fields. Kaelyn Sexton's surname has Irish origins, and she has traveled to Dublin, Ireland, where she explored her Irish heritage.
Kaelyn Sexton
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Robert Orr Black Mountain NC
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Jeffrey Belk
Choose wisely, because the choices we make, make us." ~MomzillaNC
D. Denise Dianaty
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Least Compact Congressional Districts as of 2013 District Reock Polsby-Popper Convex Hull NC – 12 2 2 1 FL – 5 3 4 2 MD – 3 27 1 3 OH – 9 1 14 4 TX – 35 5 12 5 NC – 4 13 10 6 LA – 2 28 11 7 FL – 22 6 23 18 MD – 6 9 31 8 NY – 10 42 42 16 Entries show the ranking of the district on the measure. Source: Redrawing the Map on Redistricting, 2012 (Philadelphia, PA: Azavea, 2012).
Charles S. Bullock III (Redistricting: The Most Political Activity in America)
was
N.C. Reed (Friendly Fire (Fire from the Sky #6))
Great. We’ll get ice cream when you’re done.” I felt my spirits rise. “And no worries, it’s gluten and dairy free.” And crash.
Larissa Reinhart (NC-17 (Maizie Albright Star Detective, #4))
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Seeking a Gentleman Who Knows the True Value of a Woman (19) (Craigslist Personal - women seeking men) INCALL $500 first hour $300 each additional hour $2000 overnight OUTCALL $700 first hour $350 each additional hour $2500 overnight UPGRADES B&D; $300 Roleplay $200 Costumed Roleplay $300 Around the World $200 Greek $250 Golden Showers $150 The Hitler Thing (if you don't know, don't ask!) $350 Teabagging $200 Sploshing $200 Gun Fetish $200 Foot Fetish $150 Other Fetishes P.O.R. Blow Jobs N/C - included with any of the above services Cash or Credit. Credit Cards discreetly billed to 'Avi's Plumbing
Beryl Dov
What is bad is if they are stopping you from achieving what you want to achieve, if they keep you up at night,or make you want to throw in the towel, or if they make you think something is wrong because it’s taking too long. If your impatience makes you feel like a failure, if you want to beat yourself up all the time, then maybe your current system is not working. Imagine the things you could achieve if you kept going. 
N.C Harley (Active Patience: A Simple Guide to Productive Writing)
I fear being uncomfortable if I confront my writing. Avoidance seems easier. 
N.C Harley (Active Patience: A Simple Guide to Productive Writing)
Simplicity boils down to two steps: Identify the essential. Eliminate the rest.
N.C Harley (Active Patience: A Simple Guide to Productive Writing)
In addition to X inactivation, long ncRNAs also appear to play a critical role in imprinting. Many imprinted regions contain a section that encodes a long ncRNA, which silences the expression of surrounding genes. This is similar to the effect of Xist. The protein-coding mRNAs are silenced on the copy of the chromosome which expresses the long ncRNA. For example, there is an ncRNA called Air, expressed in the placenta, exclusively from the paternally inherited mouse chromosome 11. Expression of Air ncRNA represses the nearby Igf2r gene, but only on the same chromosome12. This mechanism ensures that Igf2r is only expressed from the maternally inherited chromosome.
Nessa Carey (The Epigenetics Revolution: How Modern Biology is Rewriting our Understanding of Genetics, Disease and Inheritance)
The Air ncRNA gave scientists important insights into how these long ncRNAs repress gene expression. The ncRNA remained localised to a specific region in the cluster of imprinted genes, and acted as a magnet for an epigenetic enzyme called G9a. G9a puts a repressive mark on the histone H3 proteins in the nucleosomes deposited on this region of DNA. This histone modification creates a repressive chromatin environment, which switches off the genes.
Nessa Carey (The Epigenetics Revolution: How Modern Biology is Rewriting our Understanding of Genetics, Disease and Inheritance)
There is increasing evidence that at least some of the targeting of epigenetic modifications can be explained by interactions with long ncRNAs. Jeannie Lee and her colleagues have recently investigated long ncRNAs that bind to a complex of proteins. The complex is called PRC2 and it generates repressive modifications on histones. PRC2 contains a number of proteins, and the one that interacts with the long ncRNAs is probably EZH2. The researchers found that the PRC2 complex bound to literally thousands of different long ncRNA molecules in embryonic stem cells from mice13. These long ncRNAs may act as bait. They can stay tethered to the specific region of the genome where they are produced, and then attract repressive enzymes to shut off gene expression. This happens because the repressive enzyme complexes contain proteins like EZH2 that are capable of binding to RNA.
Nessa Carey (The Epigenetics Revolution: How Modern Biology is Rewriting our Understanding of Genetics, Disease and Inheritance)
There’s an amazing family of genes, called HOX genes. When they’re mutated in fruit flies (Drosophila melanogaster) the results are incredible phenotypes, such as legs growing out of the head14. There’s a long ncRNA known as HOTAIR, which regulates a region of genes called the HOX-D cluster. Just like the long ncRNAs investigated by Jeannie Lee, HOTAIR binds the PRC2 complex and creates a chromatin region which is marked with repressive histone modifications. But HOTAIR is not transcribed from the HOX-D position on chromosome 12. Instead it is encoded at a different cluster of genes called HOX-C on chromosome 215. No-one knows how or why HOTAIR binds at the HOX-D position. There’s a related mystery around the best studied of all long ncRNAs, Xist. Xist ncRNA spreads out along almost the entire inactive X chromosome but we really don’t know how. Chromosomes don’t normally become smothered with RNA molecules. There’s no obvious reason why Xist RNA should be able to bind like this, but we know it’s nothing to do with the sequence of the chromosome. The experiments described in the last chapter, where Xist could inactivate an entire autosome as long as it contained an X inactivation centre, showed that Xist just keeps on travelling once it’s on a chromosome. Scientists are basically still completely baffled about these fundamental characteristics of this best-studied of all ncRNAs.
Nessa Carey (The Epigenetics Revolution: How Modern Biology is Rewriting our Understanding of Genetics, Disease and Inheritance)
Twelve ncRNAs were tested, and in seven cases the scientists found the result shown in the right-hand panel of Figure 10.2. This was contrary to expectations, because it suggests that about 50 per cent of long ncRNAs may actually increase expression of neighbouring genes, not decrease it
Nessa Carey (The Epigenetics Revolution: How Modern Biology is Rewriting our Understanding of Genetics, Disease and Inheritance)
In conditions where there are an abnormal number of chromosomes, for example, it won’t just be protein-coding genes that change in number. There will also be abnormal production of ncRNAs (large and small). Because miRNAs in particular can regulate lots of other genes, the effects of disrupting miRNA copy numbers may be very extensive.
Nessa Carey (The Epigenetics Revolution: How Modern Biology is Rewriting our Understanding of Genetics, Disease and Inheritance)
However, there are two things we can say quite firmly. One is that human and chimp proteins are incredibly similar. About a third of all proteins are exactly the same between us and our knuckle-dragging cousins, and the rest differ only by one or two amino acids. Another thing we have in common is that over 98 per cent of our genomes don’t code for protein. This suggests that both species use ncRNAs to create complex regulatory networks which govern gene and protein expression. But there is a particular difference which may be very important between chimps and humans. This lies in how ncRNA is treated in the cells of the two species.
Nessa Carey (The Epigenetics Revolution: How Modern Biology is Rewriting our Understanding of Genetics, Disease and Inheritance)
In order for us to press on and never give up, you must let the work be the reward. Not everything will be well received, not everything will get published. There will be setbacks. We have heard it all before. It’s not the destination but the journey. You have an idea. You obviously can write. Enjoy the process, and if you can't, find ways you can.
N.C Harley (Active Patience: A Simple Guide to Productive Writing)
Nobody knows how long anything is going to take or whether it will be successful.By actively and proactively persevering, we can weave our threads slowly, building our stories one thread at a time. Jump and you will sprout wings. Let
N.C Harley (Active Patience: A Simple Guide to Productive Writing)
The Energy of the mind is the essence of life” - Aristotle 
N.C Harley (Active Patience: A Simple Guide to Productive Writing)
Healthy habits that become second nature are essential for Active Patience. Energy in. Energy out. Ideas, writing and all of our creative energy are slowly and regularly released. Exercise keeps us calm, cool and collected,it releases endorphins and it builds our store of energy.
N.C Harley (Active Patience: A Simple Guide to Productive Writing)
The gratification comes in the doing, not in the results.” - James Dean, Actor
N.C Harley (Active Patience: A Simple Guide to Productive Writing)
ncRNAs have recently been implicated in Lamarckian transmission of inherited characteristics. In one example, fertilised mouse eggs were injected with a miRNA which targeted a key gene involved in growth of heart tissue. The mice which developed from these eggs had enlarged hearts (cardiac hypertrophy) suggesting that the early injection of the miRNA disturbed the normal developmental processes. Remarkably, the offspring of these mice also had a high frequency of cardiac hypertrophy. This was apparently because the abnormal expression of the miRNA was recreated during generation of sperm in these mice. There was no change in the DNA code of the mice, so this was a clear case of a miRNA driving epigenetic inheritance
Nessa Carey (The Epigenetics Revolution: How Modern Biology is Rewriting our Understanding of Genetics, Disease and Inheritance)
But if ncRNAs are so important for cellular function, surely we would expect to find that sometimes diseases are caused by problems with them. Shouldn’t there be lots of examples where defects in production or expression of ncRNAs lead to clinical disorders, aside from the imprinting or X inactivation conditions? Well, yes and no. Because these ncRNAs are predominantly regulatory molecules, acting in networks that are rich in compensatory mechanisms, defects may only have relatively subtle impacts. The problem this creates experimentally is that most genetic screens are good at detecting the major phenotypes caused by mutations in proteins, but may not be so useful for more subtle effects.
Nessa Carey (The Epigenetics Revolution: How Modern Biology is Rewriting our Understanding of Genetics, Disease and Inheritance)
There is a small ncRNA called BC1 which is expressed in specific neurons in mice. When researchers at the University of Munster in Germany deleted this ncRNA, the mice seemed fine. But then the scientists moved the mutant animals from the very controlled laboratory setting into a more natural environment. Under these conditions, it became clear that the mutants were not the same as normal mice. They were reluctant to explore their surroundings and were anxious37. If they had simply been left in their cages, we would never have appreciated that loss of the BC1 ncRNA actually had a quite pronounced effect on behaviour. A clear case of what we see being dependent on how we look.
Nessa Carey (The Epigenetics Revolution: How Modern Biology is Rewriting our Understanding of Genetics, Disease and Inheritance)
Tourette’s syndrome is a neurodevelopmental disorder where the patient frequently suffers from involuntary convulsive movements (tics) which in some cases are associated with involuntary swearing. Two unrelated individuals with this disorder were shown to have the same single base change in the 3′ UTR of a gene called SLITRK139. SLITRK1 appears to be required for neuronal development. The base change in the Tourette’s patients introduced a binding site for a short ncRNA called miR-189. This suggests that SLITRK1 expression may be abnormally down-regulated via such binding, at critical points in development. This alteration is only present in a few cases of Tourette’s but raises the tantalising suggestion that mis-regulation of miRNA binding sites in other neuronal genes may be involved in other patients.
Nessa Carey (The Epigenetics Revolution: How Modern Biology is Rewriting our Understanding of Genetics, Disease and Inheritance)
«Las Biblias cubiertas de polvo dan lugar a vidas sucias».
Ted N.C. Wilson (A las puertas (Spanish Edition))
Con el fin de apartarnos de la Biblia y de lo que ella enseña, el diablo utilizará cualquier medio: la televisión, el entretenimiento y las diversiones, el trabajo, la música, controversias, falsas enseñanzas, discordias, los problemas económicos, y cualquier cosa que pueda absorber nuestro tiempo y mantenernos alejados de la Palabra de Dios.
Ted N.C. Wilson (A las puertas (Spanish Edition))
Tubman: Myth, Memory and History. Duke University Press: Durham, NC, 2007,
Stephen Cope (The Great Work of Your Life: A Guide for the Journey to Your True Calling)
Perfectionism dictates it’s all or nothing. If I fall short one day or don't create at all, my head gives me that free pass because I didn't fit the ideal.Remember, it’s an all or nothing situation. 
N.C Harley (Active Patience: A Simple Guide to Productive Writing)
By actively pursuing what you love with an unshakeable belief in yourself and your abilities, you depend on nothing but yourself. At the end of the day, you have everything you need to create exactly what you want. 
N.C Harley (Active Patience: A Simple Guide to Productive Writing)
Belief and delusions are incestuous siblings.” 
N.C Harley (Active Patience: A Simple Guide to Productive Writing)
según se acerca el tiempo del regreso de Cristo, es preciso que sigamos la dirección divina al implementar una campaña de evangelización enfocada en todas las metrópolis. Con ese fin debemos hacer todos los esfuerzos posibles, según se nos indica en la Biblia y en el Espíritu de Profecía.
Ted N.C. Wilson (A las puertas (Spanish Edition))
procrastination will tie you into a knot. You’re actively seeking distractions and avoidance instead of actively working on your goal patiently.
N.C Harley (Active Patience: A Simple Guide to Productive Writing)
It knows the pain of regret and disappointment if you don't get to work. It knows the big picture even if you don't. It can see a mile down the road. It knows what you can become if you act on its advice. 
N.C Harley (Active Patience: A Simple Guide to Productive Writing)
Patience is not passive; on the contrary, it is active: it is concentrated strength.
N.C Harley (Active Patience: A Simple Guide to Productive Writing)
Working on any long-term project like a book is a test. Testing your patience is part of the game. Take it in your stride. Don't be so easily defeated. 
N.C Harley (Active Patience: A Simple Guide to Productive Writing)
Sometimes a pessimist is only an optimist with extra information.
N.C Harley (Active Patience: A Simple Guide to Productive Writing)
Perfectionism is self -abuse of the highest order
N.C Harley (Active Patience: A Simple Guide to Productive Writing)
A year from now you may wish you had started today.
N.C Harley (Active Patience: A Simple Guide to Productive Writing)
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TeIItaIe Inc. (Minecraft: Story Mode)
Everything that’s realistic has some sort of ugliness to it. Even a flower is ugly when it wilts, a bird when it seeks its prey, the ocean when it becomes violent.
N.C Harley (Active Patience: A Simple Guide to Productive Writing)
Fear and perfectionism take over. Judgement fills our guts. Then the ultimate disappointment―in yourself, your project, your abilities.Do you really want to be the person who couldn't follow through? Who couldn't stick it out for another six months or, god forbid, another year? 
N.C Harley (Active Patience: A Simple Guide to Productive Writing)
Jesús vuelve pronto, pero antes de su regreso el diablo intentará también falsificar ese acontecimiento. No podremos creer ni siquiera lo que veamos con nuestros propios ojos. Tendremos que depender totalmente de nuestra fe en la Palabra de Dios.
Ted N.C. Wilson (A las puertas (Spanish Edition))
He hadn’t hooked up with anyone else. Hell, he couldn’t think about anyone other than Nora. Hadn’t since the day he’d met her.
Elisabeth Naughton (All He Wants for Christmas (The Rapture, #3; Spurs and Stripes, #2; Against All Odds, #3; O'Connor Family, #1; Rough Riders Hockey, #1; Holly NC, #1-6 & 7))
This particular song’s just something that’s been floating around inside me for a long time,” Tate went on. “Is she the one who got away? Yeah. She is. But it’s because she got away that I—that we,” he clarified, “are all here now.” “How do you mean?” the interviewer asked. Tate was silent for several heartbeats, then said, “When I met her, I was playing ball. She knew I wasn’t that good. But she also saw a talent in me I didn’t even know I had. She’s the one who encouraged my music. I lost her after that summer, but it’s because I lost her that Kendrick was even formed. So yeah, she is ‘Everything.’ She’s everything I have and everything I’m missing.” “Would it be safe to assume you work as hard as you do because you’re trying to prove to her what she’s missing?” the interviewer asked. “No,” Tate answered. “Not really.” “That’s a load of crap,” someone muttered in the background. “Okay,” Tate said louder. “Maybe it’s a little true. Did I hope she’d one day hear one of these songs about her and call me up? Sure. I think that’s the whole point of tracks like this. That there’s hope. I mean, that’s what life’s really about, right? Without hope, what the hell does a person have?” “A lot of”—BEEP—“ing fun,” Jace interjected.
Elisabeth Naughton (All He Wants for Christmas (The Rapture, #3; Spurs and Stripes, #2; Against All Odds, #3; O'Connor Family, #1; Rough Riders Hockey, #1; Holly NC, #1-6 & 7))
Guardar el sábado no es un mecanismo legalista encaminado a llevarnos al cielo, sino una señal de nuestro amor y lealtad hacia nuestro Creador y Redentor.
Ted N.C. Wilson (A las puertas (Spanish Edition))
Ella. Look at me.” Her head tossed. Her fingernails dug into his forearms. But he didn’t care. Sliding the fingers of his other hand into her hair, he forced her to face him. “Only you,” he whispered when their eyes met. “You’re it for me.” ~ Tate
Elisabeth Naughton (All He Wants for Christmas (The Rapture, #3; Spurs and Stripes, #2; Against All Odds, #3; O'Connor Family, #1; Rough Riders Hockey, #1; Holly NC, #1-6 & 7))
Las señales del regreso de Cristo no cesan de incrementarse en número y en intensidad. Desastres naturales, creciente confusión política, comprometedores avances en el ecumenismo, marcado aumento e influencia del espiritismo, deterioro de la economía mundial, desintegración social, vertiginosa caída de los valores de la familia, rechazo de la autoridad absoluta de la Santa Palabra de Dios y en especial de los Diez Mandamientos, violencia y criminalidad, deterioro moral, guerras y rumores de guerra... Todo apunta de forma inequívoca a la conclusión de la historia de este mundo y a la venida del Señor que nos llevará al cielo en un viaje final.
Ted N.C. Wilson (A las puertas (Spanish Edition))
My dad told me, ‘It takes fifteen years to be an overnight success’, and it took me seventeen and a half years.”  - Adrian Brody
N.C Harley (Active Patience: A Simple Guide to Productive Writing)
Let The Work be the Reward  In order for us to press on and never give up, you must let the work be the reward. Not everything will be well received, not everything will get published. There will be setbacks. We have heard it all before. It’s not the destination but the journey. You have an idea. You obviously can write. Enjoy the process, and if you can't, find ways you can. Have fun with your writing. 
N.C Harley (Active Patience: A Simple Guide to Productive Writing)