Nc Quotes

NC passed law against global warming science, therefore it's not happening. So I'm ignoring Twitter's 140-character limit, so it's not happ

Optimism was for children. Once you reached adulthood then you had to join the rest of the world as a realist - life was a bag of shit you were expected to pay for.

I like misty autumn mornings, and cold snowy winter nights. Rainstorms bring me innerpeace, thunder sets my soul alight. I care not for summer, days too long, the heavy heat. Give me candlelight evenings, early darkness, a silent street.

Like every other tiny-ass town in the South, there were plenty of crappy Mexican restaurants to choose from. Not fancy Mexican like I eat in L.A. When I eat Mexican food in L.A., it’s like a kale salad with pepitas and soy beef tacos with fresh pico de gallo. In NC, it’s a five-dollar plate of cheese enchiladas with refried beans and a bowl of melted white cheese dip. Essentially you just walk in and ask for a plate of brown with a little iceberg lettuce, and it’s fucking delish.

Dear Daniel, How do you break up with your boyfriend in a way that tells him, "I don't want to sleep with you on a regular basis anymore, but please be available for late night booty calls if I run out of other options"? Lily Charlotte, NC Dear Lily, The story's so old you can't tell it anymore without everyone groaning, even your oldest friends with the last of their drinks shivering around the ice in their dirty glasses. The music playing is the same album everyone has. Those shoes, everybody has the same shoes on. It looked a little like rain so on person brought an umbrella, useless now in the starstruck clouded sky, forgotten on the way home, which is how the umbrella ended up in her place anyway. Everyone gets older on nights like this. And still it's a fresh slap in the face of everything you had going, that precarious shelf in the shallow closet that will certainly, certainly fall someday. Photographs slipping into a crack to be found by the next tenant, that one squinter third from the left laughing at something your roommate said, the coaster from that place in the city you used to live in, gone now. A letter that seemed important for reasons you can't remember, throw it out, the entry in the address book you won't erase but won't keep when you get a new phone, let it pass and don't worry about it. You don't think about them; "I haven't thought about them in forever," you would say if anybody brought it up, and nobody does." You think about them all the time. Close the book but forget to turn off the light, just sit staring in bed until you blink and you're out of it, some noise on the other side of the wall reminding you you're still here. That's it, that's everything. There's no statue in the town square with an inscription with words to live by. The actor got slapped this morning by someone she loved, slapped right across the face, but there's no trace of it on any channel no matter how late you watch. How many people--really, count them up--know where you are? How many will look after you when you don't show up? The churches and train stations are creaky and the street signs, the menus, the writing on the wall, it all feels like the wrong language. Nobody, nobody knows what you're thinking of when you lean your head against the wall. Put a sweater on when you get cold. Remind yourself, this is the night, because it is. You're free to sing what you want as you walk there, the trees rustling spookily and certainly and quietly and inimitably. Whatever shoes you want, fuck it, you're comfortable. Don't trust anyone's directions. Write what you might forget on the back of your hand, and slam down the cheap stuff and never mind the bad music from the window three floors up or what the boys shouted from the car nine years ago that keeps rattling around in your head, because you're here, you are, for the warmth of someone's wrists where the sleeve stops and the glove doesn't quite begin, and the slant of the voice on the punch line of the joke and the reflection of the moon in the water on the street as you stand still for a moment and gather your courage and take a breath before stealing away through the door. Look at it there. Take a good look. It looks like rain. Love, Daniel Handler

Dear Patton: I've been feeling blue lately but I wasn't sure if it had anything to do with the amount of rain we've had over the last few weeks. What are your thoughts on that? Ms. Diller Cary, NC Dear Ms. Diller: Rain can have a profound effect on someone inclined toward melancholy. I live in Los Angeles, and, as of this writing, we've just experienced three weeks of unending late-winter storms. The sky has been a limitless bowl of sludgy, hopeless gray. The ground, soaked and muddy, emits burbly, hissing spurts with every step, which sound like a scornful parent who sees no worth, hope, or value in their offspring. The morning light through my bedroom window promises nothing but a damp, unwelcoming day of thankless busywork and futile, doomed chores. My breakfast cereal tastes like being ostracized. My morning coffee fills my stomach with dread. What's the point of even answering this question? The rain--it will not stop. Even if I say something that will help you--which I won't, because I'm such a useless piece of shit--you'll eventually die and I'll die and everyone we know will die and this book will turn to dust and the universe will run down and stop, and dead dead dead dead dead. Dead. Read Chicken Soup for the Soul, I guess. Dead. Dead dead. Patton

NC: You’re right, but I think it tells you something very interesting about Western culture. When they went to the concentration camps and were appalled, they did not say, “Let’s save the survivors”; they said, “Let someone else pay for saving the survivors.” IP: Exactly.

It was hard to get ahead when your energy and time were dedicated to keeping a roof over your head and the utilities on.

Sand might shift with wind or tide, but it didn’t really change, it just rearranged itself.

The Concept of Gender Does Not Exist....All There Is, Is What Is

The Energy of the mind is the essence of life

Remember, to embody Active Patience, we must be in it for the long term.

scientists have discovered that chromosomal DNA—the DNA responsible for transmitting physical traits, such as the color of our hair, eyes, and skin—surprisingly makes up less than 2 percent of our total DNA.14 The other 98 percent consists of what is called noncoding DNA (ncDNA), and is responsible for many of the emotional, behavioral, and personality traits we inherit.

For anything worth having one must pay the price; and the price is always work, patience, love, self-sacrifice. No paper currency, no promises to pay, but the gold of real service.” - John Burroughs, Naturalist and Essayist 

From the line, watching, three things are striking: (a) what on TV is a brisk crack is here a whooming roar that apparently is what a shotgun really sounds like; (b) trapshooting looks comparatively easy, because now the stocky older guy who's replaced the trim bearded guy at the rail is also blowing these little fluorescent plates away one after the other, so that a steady rain of lumpy orange crud is falling into the Nadir's wake; (c) a clay pigeon, when shot, undergoes a frighteningly familiar-looking midflight peripeteia -- erupting material, changing vector, and plummeting seaward in a corkscrewy way that all eerily recalls footage of the 1986 Challenger disaster. All the shooters who precede me seem to fire with a kind of casual scorn, and all get eight out of ten or above. But it turns out that, of these six guys, three have military-combat backgrounds, another two are L. L. Bean-model-type brothers who spend weeks every year hunting various fast-flying species with their "Papa" in southern Canada, and the last has got not only his own earmuffs, plus his own shotgun in a special crushed-velvet-lined case, but also his own trapshooting range in his backyard (31) in North Carolina. When it's finally my turn, the earmuffs they give me have somebody else's ear-oil on them and don't fit my head very well. The gun itself is shockingly heavy and stinks of what I'm told is cordite, small pubic spirals of which are still exiting the barrel from the Korea-vet who preceded me and is tied for first with 10/10. The two brothers are the only entrants even near my age; both got scores of 9/10 and are now appraising me coolly from identical prep-school-slouch positions against the starboard rail. The Greek NCOs seem extremely bored. I am handed the heavy gun and told to "be bracing a hip" against the aft rail and then to place the stock of the weapon against, no, not the shoulder of my hold-the-gun arm but the shoulder of my pull-the-trigger arm. (My initial error in this latter regard results in a severely distorted aim that makes the Greek by the catapult do a rather neat drop-and-roll.) Let's not spend a lot of time drawing this whole incident out. Let me simply say that, yes, my own trapshooting score was noticeably lower than the other entrants' scores, then simply make a few disinterested observations for the benefit of any novice contemplating trapshooting from a 7NC Megaship, and then we'll move on: (1) A certain level of displayed ineptitude with a firearm will cause everyone who knows anything about firearms to converge on you all at the same time with cautions and advice and handy tips. (2) A lot of the advice in (1) boils down to exhortations to "lead" the launched pigeon, but nobody explains whether this means that the gun's barrel should move across the sky with the pigeon or should instead sort of lie in static ambush along some point in the pigeon's projected path. (3) Whatever a "hair trigger" is, a shotgun does not have one. (4) If you've never fired a gun before, the urge to close your eyes at the precise moment of concussion is, for all practical purposes, irresistible. (5) The well-known "kick" of a fired shotgun is no misnomer; it knocks you back several steps with your arms pinwheeling wildly for balance, which when you're holding a still-loaded gun results in mass screaming and ducking and then on the next shot a conspicuous thinning of the crowd in the 9-Aft gallery above. Finally, (6), know that an unshot discus's movement against the vast lapis lazuli dome of the open ocean's sky is sun-like -- i.e., orange and parabolic and right-to-left -- and that its disappearance into the sea is edge-first and splashless and sad.

The more you exercise the more energy you have, the more energy you have the more clearly you think. Active Patience is calm. Exercise reduces panic and anxiety behaviour. This is the kind of behaviour that makes us feel we are in a hurry and trying to do a million different things at once.We become paralysed, and beat ourselves up for it.

money can't buy you happiness. What it can do, however, is buy you lots of expensive and meaningless crap to help disguise how unhappy you actually are.

I know you are there before I turn around. There's a shift in the air, the wind changes its direction ever so slightly, but just enough to make me aware

Every time I believed Rya owned all of me, she would teach me differently. She would find a part of me I didn’t know I had, and own that, too.

The on-screen depiction of oral sex performed on women has consistently earned movies an NC-17 rating – Blue Valentine, Boys Don’t Cry, and Charlie Countryman are a few that come to mind. The same standard has certainly not been applied to on-screen blow jobs. I often think of 2013s Lovelace, a biopic about the star of the 1972 porn film Deep Throat. This was an entire movie dedicated to fellatio, and to extreme sexual violence, and even that was given a mild R. Sure, let the kids watch a porn star get repeatedly raped, but female desire? No, no, no.

His sophomore Creative Writing class was as silent as a room full of teenagers could be, only whispering and shuffling a little as they tried to complete their papers. This wasn’t one of the “easy A” electives, and he usually got the kids who were serious about the idea of being better writers. Half of them just wanted to get better so they could improve their Pacific Rim hurt/comfort fanfic, but there was nothing wrong with that. Besides, one of them had let slip that a good portion of the class was posting on Archive of Our Own, and he’d spent a few nights with a beer in his hand, learning more about his students. He hadn’t read the NC-17 pieces—there were professional limits—and yet he felt he respected them more as writers because he’d seen what they were capable of when they weren’t being graded.

More people continue to join the party, some familiar faces, and some new ones that I look forward to getting to know. I smile and wave as I spot Lucy through the crowd, where she stands outside Logan’s Tavern laughing. She’s joined by the two girls she met when we first arrived here that she now classes as her best friends. She’s recently completed her first year of an art course at college. Seems she has a real flair for it, and I've never seen her happier. Her watercolours of Ceaders Bay, which take pride of place on the walls of our new home, are nothing short of phenomenal. She has recently painted one to send as a house warming gift to my parents, who are now living up the coast from us in their beloved village of Pemblington

http://www.batteriesmall.com.au/hp-co... HP COMPAQ Business Notebook NC6400 Laptop Battery

Rod Cockshutt, Professor Emeritus at N.C. State University called my book, Evidence of Insanity, "an extraordinary achievement" and told me to not change the last 10-15 pages no matter what.

Cory Doctorow hat dieses Werk unter der Creative-Commons-Lizenz(CC-BY-NC-SA) veröffentlicht die es jedermann erlaubt, das Werk frei zu verbreiten und zu bearbeiten ... (siehe wikipedia "little brother", dort auch Links zu den ebooks der Übersetzung) Unter Nutzung dieser Lizenz hat Christian Wöhrl eine deutsche Übersetzung des Romans angefertigt. Aus dieser ist ein Fanhörbuchprojekt entstanden. ... hier meine Zitate aus Readmill: Ich hatte also grade 10 Sekunden auf dreitausend Rechnern gemietet und jeden einzelnen angewiesen, eine SMS oder einen VoIP-Anruf an Charles' Handy abzusetzen; dessen Nummer hatte ich mal während einer dieser verhängnisvollen Bürositzungen bei Benson von einem Post-it abgelesen. Muss ich erwähnen, dass Charles' Telefon nicht in der Lage war, damit umzugehen? Zuerst ließen die SMS den Gerätespeicher überlaufen, sodass das Handy nicht mal mehr seine Routinen ausführen konnte, etwa das Klingeln zu koordinieren und die gefälschten Rufnummern der eingehenden Anrufe aufzuzeichnen. (Wusstet ihr, dass es völlig simpel ist, die Rückrufnummer einer Anruferkennung zu faken? Dafür gibts ungefähr 50 verschiedene Möglichkeiten - einfach mal "Anrufer-ID fälschen" googeln...) Charles starrte sein Telefon fassungslos an und hackte auf ihm herum, die wulstigen Augenbrauen regelrecht verknotet ob der Anstrengung, dieser Dämonen Herr zu werden, die das persönlichste seiner Geräte in Besitz genommen hatten. Sekunden später kackte Charles' Handy spektakulär ab. Zehntausende von zufälligen Anrufen und SMS liefen parallel bei ihm auf, sämtliche Warn- und Klingeltöne meldeten sich gleichzeitig und dann wieder und wieder. Den Angriff hatte ich mithilfe eines Botnetzes bewerkstelligt, was mir einerseits ein schlechtes Gewissen bereitete; aber andererseits war es ja im Dienst einer guten Sache. In Botnetzen fristen infizierte Rechner ihr untotes Dasein. Wenn du dir einen Wurm oder Virus fängst, sendet dein Rechner eine Botschaft an einen Chat-Kanal im IRC, dem Internet Relay Chat. Diese Botschaft zeigt dem Botmaster, also dem Typen, der den Wurm freigesetzt hat, dass da Computer sind, die auf seinen Befehl warten. Botnetze sind enorm mächtig, da sie aus Tausenden, manchmal Hunderttausenden von Rechnern bestehen, die über das ganze Internet verteilt sind, meist über Breitbandleitungen verbunden sind und auf schnelle Heim-PCs Das Buch passte grade so in die Mikrowelle, die sogar noch unappetitlicher aussah als beim letzten Mal, als ich sie brauchte. Ich wickelte das Buch penibel in Papiertücher, bevor ich es reinsteckte. "Mann, Lehrer sind Schweine", zischelte ich. Darryl, bleich und angespannt, erwiderte nichts. Dann packte ich das primäre Arbeitsgerät unserer Schule wieder aus und wählte den Klassenzimmer-Modus. Die SchulBooks waren die verräterischsten Geräte von allen - zeichneten jede Eingabe auf, kontrollierten den Netzwerkverkehr auf verdächtige Eingaben, zählten alle Klicks, zeichneten jeden flüchtigen Gedanken auf, den du übers Netz verbreitetest. Wir hatten sie in meinem ersten Jahr hier bekommen, und es hatte bloß ein paar Monate gedauert, bis der Reiz dieser Dinger verflogen war. Sobald die Leute merkten, dass diese "kostenlosen" Laptops in Wirklichkeit für die da oben arbeiteten (und im Übrigen mit massenhaft nerviger Werbung verseucht waren), fühlten die Kisten sich plötzlich sehr, sehr schwer an. Mein SchulBook zu cracken war simpel gewesen. Der Crack war binnen eines Monats nach Einführung der Maschine online zu finden, und es war eine billige Nummer - bloß ein DVD-Image runterladen, brennen, ins SchulBook stecken und die Kiste hochfahren, während man ein paar Tasten gleichzeitig gedrückt hielt. Die DVD erledigte den Rest und installierte etliche versteckte Programme auf dem Laptop, die von den täglichen Fernprüfungs-Routinen der Schulleitung nicht gefunden werden konnten.

I'm not modest,' she said last year. 'I have no modesty. Modesty is a learned behavior. But I do pray for humility, because humility comes from the inside out.' Angelou, a renaissance woman and cultural pioneer, died Wednesday at her home in Winston-Salem, N.C. She was 86.

was just bad-tempered. I stayed

People can talk all they want about the Big Ten. About Michigan and Ohio State and Indiana and Kentucky or whatever, but there's no way that compares. They're in different states. Here, we share the same dry cleaners." - Mike Kryzewski

When I look through your eyes I see me, who am I? do you see me, really?

When I open my eyes I see you, even though your not there, in my heart you are, my love of my life is in my eyes and my heart you are...

If you gave me a chance to walk in your shoes I will, but when you walk in mine don't get disappointed...

Florists and Bouquets Flowers shop in Greenville NC

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It's the hardest work in the world to try not to work. - N.C. Wyeth

So he was doing the only thing he could do, under the circumstances. Something else.

They lived in the same house,” McCullough writes, “worked together six days a week, ate their meals together, kept their money in a joint bank account, even ‘thought together,’ Wilbur said.” Neither brother ever married or, apparently, had romantic attachments. The most important woman in their life was their younger sister, Katharine, whose steadfast devotion to her brilliant brothers would be difficult to accept as anything but cliché were it not for the evidence in her correspondence with her brothers. These letters are a large part of the record of what happened at Kitty Hawk, N.C., ideal material for McCullough’s narrative gifts as he unreels the unlikely story that took place on that thin strip of beach. The Wrights had the good wishes and eager

Themes like,This year is going to be my year of being creative everyday, will help keep you on track and make you feel like you have achieved something even with the smallest of contributions. 

Everything that’s realistic has some sort of ugliness to it. Even a flower is ugly when it wilts, a bird when it seeks its prey, the ocean when it becomes violent.

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Let The Work be the Reward  In order for us to press on and never give up, you must let the work be the reward. Not everything will be well received, not everything will get published. There will be setbacks. We have heard it all before. It’s not the destination but the journey. You have an idea. You obviously can write. Enjoy the process, and if you can't, find ways you can. Have fun with your writing. 

For anything worth having one must pay the price; and the price is always work, patience, love, self-sacrifice. No paper currency, no promises to pay, but the gold of real service.

Sometimes a pessimist is only an optimist with extra information.

Perfectionism is self -abuse of the highest order

The gratification comes in the doing, not in the results.” - James Dean, Actor

Patience is not passive; on the contrary, it is active: it is concentrated strength.

procrastination will tie you into a knot. You’re actively seeking distractions and avoidance instead of actively working on your goal patiently.

By actively pursuing what you love with an unshakeable belief in yourself and your abilities, you depend on nothing but yourself. At the end of the day, you have everything you need to create exactly what you want. 

Belief and delusions are incestuous siblings.” 

The thing about delusional fantasies is that when you get what you thought you wanted, the reality is nothing like the fantasy. We are setting ourselves up for disappointment. 

Fear and perfectionism take over. Judgement fills our guts. Then the ultimate disappointment―in yourself, your project, your abilities.Do you really want to be the person who couldn't follow through? Who couldn't stick it out for another six months or, god forbid, another year? 

Working on any long-term project like a book is a test. Testing your patience is part of the game. Take it in your stride. Don't be so easily defeated. 

Patience is required for the unfolding of anything. Everything that will ever exist has been created. It’s just waiting for you to sit down and do the work. Be patient with your dreams. Be patient with yourself. Amazing things will happen. The world is patiently waiting for you to give us your gift.  Experiment and find what works for you and go for it! Be active. Never stop and never give up. 

It knows the pain of regret and disappointment if you don't get to work. It knows the big picture even if you don't. It can see a mile down the road. It knows what you can become if you act on its advice. 

What is bad is if they are stopping you from achieving what you want to achieve, if they keep you up at night,or make you want to throw in the towel, or if they make you think something is wrong because it’s taking too long. If your impatience makes you feel like a failure, if you want to beat yourself up all the time, then maybe your current system is not working. Imagine the things you could achieve if you kept going. 

Mental anxiety comes from inaction. The more you don't do, the more anxiety it creates. 

I fear being uncomfortable if I confront my writing. Avoidance seems easier. 

Healthy habits that become second nature are essential for Active Patience. Energy in. Energy out. Ideas, writing and all of our creative energy are slowly and regularly released. Exercise keeps us calm, cool and collected,it releases endorphins and it builds our store of energy.

Perfectionism dictates it’s all or nothing. If I fall short one day or don't create at all, my head gives me that free pass because I didn't fit the ideal.Remember, it’s an all or nothing situation. 

Constantly being in a delusional fantasy means you are never in the moment. Your in the time machine of your head. You live in either the past when you could have got it right,or the future when you might get that thing that is missing from your life.

The active is in our heads and the patience is in the waiting. Hope accumulates and again we actively get nowhere.  Active Patience is about the real grit and hard work, however long it takes. Being aware and alert while we work and not in our time machine.

We don't hope for the best. We bank on our actual efforts to take us to where we want to go. 

We must all suffer one of two things: The pain of discipline or the pain of regret and disappointment.

Simplicity boils down to two steps: Identify the essential. Eliminate the rest.

«Las Biblias cubiertas de polvo dan lugar a vidas sucias».

There is increasing evidence that at least some of the targeting of epigenetic modifications can be explained by interactions with long ncRNAs. Jeannie Lee and her colleagues have recently investigated long ncRNAs that bind to a complex of proteins. The complex is called PRC2 and it generates repressive modifications on histones. PRC2 contains a number of proteins, and the one that interacts with the long ncRNAs is probably EZH2. The researchers found that the PRC2 complex bound to literally thousands of different long ncRNA molecules in embryonic stem cells from mice13. These long ncRNAs may act as bait. They can stay tethered to the specific region of the genome where they are produced, and then attract repressive enzymes to shut off gene expression. This happens because the repressive enzyme complexes contain proteins like EZH2 that are capable of binding to RNA.

Tourette’s syndrome is a neurodevelopmental disorder where the patient frequently suffers from involuntary convulsive movements (tics) which in some cases are associated with involuntary swearing. Two unrelated individuals with this disorder were shown to have the same single base change in the 3′ UTR of a gene called SLITRK139. SLITRK1 appears to be required for neuronal development. The base change in the Tourette’s patients introduced a binding site for a short ncRNA called miR-189. This suggests that SLITRK1 expression may be abnormally down-regulated via such binding, at critical points in development. This alteration is only present in a few cases of Tourette’s but raises the tantalising suggestion that mis-regulation of miRNA binding sites in other neuronal genes may be involved in other patients.

There is a small ncRNA called BC1 which is expressed in specific neurons in mice. When researchers at the University of Munster in Germany deleted this ncRNA, the mice seemed fine. But then the scientists moved the mutant animals from the very controlled laboratory setting into a more natural environment. Under these conditions, it became clear that the mutants were not the same as normal mice. They were reluctant to explore their surroundings and were anxious37. If they had simply been left in their cages, we would never have appreciated that loss of the BC1 ncRNA actually had a quite pronounced effect on behaviour. A clear case of what we see being dependent on how we look.

Guardar el sábado no es un mecanismo legalista encaminado a llevarnos al cielo, sino una señal de nuestro amor y lealtad hacia nuestro Creador y Redentor.

The Air ncRNA gave scientists important insights into how these long ncRNAs repress gene expression. The ncRNA remained localised to a specific region in the cluster of imprinted genes, and acted as a magnet for an epigenetic enzyme called G9a. G9a puts a repressive mark on the histone H3 proteins in the nucleosomes deposited on this region of DNA. This histone modification creates a repressive chromatin environment, which switches off the genes.

Twelve ncRNAs were tested, and in seven cases the scientists found the result shown in the right-hand panel of Figure 10.2. This was contrary to expectations, because it suggests that about 50 per cent of long ncRNAs may actually increase expression of neighbouring genes, not decrease it

Jesús vuelve pronto, pero antes de su regreso el diablo intentará también falsificar ese acontecimiento. No podremos creer ni siquiera lo que veamos con nuestros propios ojos. Tendremos que depender totalmente de nuestra fe en la Palabra de Dios.

Tubman: Myth, Memory and History. Duke University Press: Durham, NC, 2007,

World societies are defining uncontrollable physical actions as deviant behavior, and obstructing, imprisoning, or confining to mental hospitals those who cannot suppress these actions.

Jim Valvano and North Carolina State actually came close to beating Dean Smith and North Carolina both times the two teams faced each other during the regular season in 1980–81. Carolina won a pair of three-point games, but—naturally—that wasn’t the way Valvano told the story in the years that followed. The way Valvano told it, Carolina won both games in blowouts. He counted on the fact that most of his listeners wouldn’t remember the two games. “So, the second time we get blown out, an old State alumnus comes up to me and he says, ‘Coach, I know you’re a Yankee and you don’t understand about tradition down here, but we cannot be losing to the Tar Heels this way.’ “I say to him, ‘No, I do get it. I know all about the tradition down here and I promise you, next season we’re going to do a lot better against them.’ “He shakes his head and says, ‘Coach, you just don’t get it. If you lose to the Tar Heels here in Reynolds [Coliseum] next season, we’re going to kill your dog.’ “Okay, I’m just a little nervous now because the guy isn’t smiling even a little bit. But I say to him, ‘Look, I have to tell you, I don’t have a dog, but I hear you loud and clear.’ “He just nods and walks away. Next morning I go to the front door to get my newspaper, and when I open the door there’s a basket on my front step. I look under the blanket and there’s the cutest little puppy you’ve ever seen in your life. There’s a note attached to the puppy’s collar. It says, ‘Don’t get too attached.’ ” The story illustrated the intensity of the Triangle rivalries among N.C. State, North Carolina, and Duke.

7, 1, 9, 3, 2, 4, 0. For NC.

In order for us to press on and never give up, you must let the work be the reward. Not everything will be well received, not everything will get published. There will be setbacks. We have heard it all before. It’s not the destination but the journey. You have an idea. You obviously can write. Enjoy the process, and if you can't, find ways you can.

Nobody knows how long anything is going to take or whether it will be successful.By actively and proactively persevering, we can weave our threads slowly, building our stories one thread at a time. Jump and you will sprout wings. Let

The Energy of the mind is the essence of life” - Aristotle 

… Remember, no matter where you go, there you are. —Buckaroo Banzai

There’s an amazing family of genes, called HOX genes. When they’re mutated in fruit flies (Drosophila melanogaster) the results are incredible phenotypes, such as legs growing out of the head14. There’s a long ncRNA known as HOTAIR, which regulates a region of genes called the HOX-D cluster. Just like the long ncRNAs investigated by Jeannie Lee, HOTAIR binds the PRC2 complex and creates a chromatin region which is marked with repressive histone modifications. But HOTAIR is not transcribed from the HOX-D position on chromosome 12. Instead it is encoded at a different cluster of genes called HOX-C on chromosome 215. No-one knows how or why HOTAIR binds at the HOX-D position. There’s a related mystery around the best studied of all long ncRNAs, Xist. Xist ncRNA spreads out along almost the entire inactive X chromosome but we really don’t know how. Chromosomes don’t normally become smothered with RNA molecules. There’s no obvious reason why Xist RNA should be able to bind like this, but we know it’s nothing to do with the sequence of the chromosome. The experiments described in the last chapter, where Xist could inactivate an entire autosome as long as it contained an X inactivation centre, showed that Xist just keeps on travelling once it’s on a chromosome. Scientists are basically still completely baffled about these fundamental characteristics of this best-studied of all ncRNAs.

My dad told me, ‘It takes fifteen years to be an overnight success’, and it took me seventeen and a half years.”  - Adrian Brody

Con el fin de apartarnos de la Biblia y de lo que ella enseña, el diablo utilizará cualquier medio: la televisión, el entretenimiento y las diversiones, el trabajo, la música, controversias, falsas enseñanzas, discordias, los problemas económicos, y cualquier cosa que pueda absorber nuestro tiempo y mantenernos alejados de la Palabra de Dios.

In addition to X inactivation, long ncRNAs also appear to play a critical role in imprinting. Many imprinted regions contain a section that encodes a long ncRNA, which silences the expression of surrounding genes. This is similar to the effect of Xist. The protein-coding mRNAs are silenced on the copy of the chromosome which expresses the long ncRNA. For example, there is an ncRNA called Air, expressed in the placenta, exclusively from the paternally inherited mouse chromosome 11. Expression of Air ncRNA represses the nearby Igf2r gene, but only on the same chromosome12. This mechanism ensures that Igf2r is only expressed from the maternally inherited chromosome.

A year from now you may wish you had started today.

But if ncRNAs are so important for cellular function, surely we would expect to find that sometimes diseases are caused by problems with them. Shouldn’t there be lots of examples where defects in production or expression of ncRNAs lead to clinical disorders, aside from the imprinting or X inactivation conditions? Well, yes and no. Because these ncRNAs are predominantly regulatory molecules, acting in networks that are rich in compensatory mechanisms, defects may only have relatively subtle impacts. The problem this creates experimentally is that most genetic screens are good at detecting the major phenotypes caused by mutations in proteins, but may not be so useful for more subtle effects.

In conditions where there are an abnormal number of chromosomes, for example, it won’t just be protein-coding genes that change in number. There will also be abnormal production of ncRNAs (large and small). Because miRNAs in particular can regulate lots of other genes, the effects of disrupting miRNA copy numbers may be very extensive.

However, there are two things we can say quite firmly. One is that human and chimp proteins are incredibly similar. About a third of all proteins are exactly the same between us and our knuckle-dragging cousins, and the rest differ only by one or two amino acids. Another thing we have in common is that over 98 per cent of our genomes don’t code for protein. This suggests that both species use ncRNAs to create complex regulatory networks which govern gene and protein expression. But there is a particular difference which may be very important between chimps and humans. This lies in how ncRNA is treated in the cells of the two species.

ncRNAs have recently been implicated in Lamarckian transmission of inherited characteristics. In one example, fertilised mouse eggs were injected with a miRNA which targeted a key gene involved in growth of heart tissue. The mice which developed from these eggs had enlarged hearts (cardiac hypertrophy) suggesting that the early injection of the miRNA disturbed the normal developmental processes. Remarkably, the offspring of these mice also had a high frequency of cardiac hypertrophy. This was apparently because the abnormal expression of the miRNA was recreated during generation of sperm in these mice. There was no change in the DNA code of the mice, so this was a clear case of a miRNA driving epigenetic inheritance

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Make the decision to rejoice when things are happy, be patient when things are bad, and find your answers in prayer.

How fast would you say the other car was going?

back ramrod straight,

In this world, none of us have more than the moment we’re in. You’re here. I’m here. Tomorrow can take care of itself.

Given time and purpose, people are resilient. It’s faith that gets us through the bad times.

The heavens declare the glory of God; the skies proclaim the work of his hands.” “Now, that’s beautiful.” “It’s Psalm 19. Verse 1.

Dealing with other people was often a crap shoot. Ultimately, you had to do what you had to do—what your conscience could live with.

service—serving other people—is a gift to all if it’s done with a glad heart.

Make the decision to rejoice when things are happy, be patient when things are bad, and find your answers in prayer. You’ll be amazed at how different the world will look to you, it will even feel different, when you find that peace within yourself.

Well, it’s not really about forgiveness, is it? Deciding not to seek revenge or ‘get even’ and to leave it in God’s hands, to trust Him to handle it, is more about acceptance and moving forward. When you do that, the anger and poison inside you will be neutralized