Mutation Quotes

We're so self-important. So arrogant. Everybody's going to save something now. Save the trees, save the bees, save the whales, save the snails. And the supreme arrogance? Save the planet! Are these people kidding? Save the planet? We don't even know how to take care of ourselves; we haven't learned how to care for one another. We're gonna save the fuckin' planet? . . . And, by the way, there's nothing wrong with the planet in the first place. The planet is fine. The people are fucked! Compared with the people, the planet is doin' great. It's been here over four billion years . . . The planet isn't goin' anywhere, folks. We are! We're goin' away. Pack your shit, we're goin' away. And we won't leave much of a trace. Thank God for that. Nothing left. Maybe a little Styrofoam. The planet will be here, and we'll be gone. Another failed mutation; another closed-end biological mistake.

Many things led to this day, for all of us. A forgotten son, a vengeful mother, a brother with a long shadow, a strange mutation. Together, they've written a tragedy.

You are a side effect," Van Houten continued, "of an evolutionary process that cares little for individual lives. You are a failed experiment in mutation.

Leaking sacks of mutated maggots?" He raises his perfectly arched eyebrow as though I'd just failed my verbal insult exam.

Like, the world is billions of years old, and life is a product of nucleotide mutation and everything. But the world is also the stories we tell about it.

To many, I was myth incarnate, the embodiment of a most superb legend, a fairy tale. Some considered me a monster, a mutation. To my great misfortune, I was once mistaken for an angel. To my mother, I was everything. To my father, nothing at all. To my grandmother, I was a daily reminder of loves long lost. But I knew the truth—deep down, I always did. I was just a girl.

Mary had a little lamb, its fleece electrostatic / And everywhere Mary went, the lights became erratic.

However, there is a way to know for certain that Noah’s Flood and the Creation story never happened: by looking at our mitochondrial DNA (mtDNA).  Mitochondria are the “cellular power plants” found in all of our cells and they have their own DNA which is separate from that found in the nucleus of the cell.  In humans, and most other species that mitochondria are found in, the father’s mtDNA normally does not contribute to the child’s mtDNA; the child normally inherits its mtDNA exclusively from its mother.  This means that if no one’s genes have mutated, then we all have the same mtDNA as our brothers and sisters and the same mtDNA as the children of our mother’s sisters, etc. This pattern of inheritance makes it possible to rule out “population bottlenecks” in our species’ history.  A bottleneck is basically a time when the population of a species dwindled to low numbers.  For humans, this means that every person born after a bottleneck can only have the mtDNA or a mutation of the mtDNA of the women who survived the bottleneck. This doesn’t mean that mtDNA can tell us when a bottleneck happened, but it can tell us when one didn’t happen because we know that mtDNA has a rate of approximately one mutation every 3,500 years (Gibbons 1998; Soares et al 2009). So if the human race were actually less than 6,000 years old and/or “everything on earth that breathed died” (Genesis 7:22) less than 6,000 years ago, which would be the case if the story of Adam and the story of Noah’s flood were true respectively, then every person should have the exact same mtDNA except for one or two mutations.  This, however, is not the case as human mtDNA is much more diverse (Endicott et al 2009), so we can know for a fact that the story of Adam and Eve and the story of Noah are fictional.   There

We’re so self-important. Everybody’s going to save something now. “Save the trees, save the bees, save the whales, save those snails.” And the greatest arrogance of all: save the planet. Save the planet, we don’t even know how to take care of ourselves yet. I’m tired of this shit. I’m tired of f-ing Earth Day. I’m tired of these self-righteous environmentalists, these white, bourgeois liberals who think the only thing wrong with this country is that there aren’t enough bicycle paths. People trying to make the world safe for Volvos. Besides, environmentalists don’t give a shit about the planet. Not in the abstract they don’t. You know what they’re interested in? A clean place to live. Their own habitat. They’re worried that some day in the future they might be personally inconvenienced. Narrow, unenlightened self-interest doesn’t impress me. The planet has been through a lot worse than us. Been through earthquakes, volcanoes, plate tectonics, continental drift, solar flares, sun spots, magnetic storms, the magnetic reversal of the poles … hundreds of thousands of years of bombardment by comets and asteroids and meteors, worldwide floods, tidal waves, worldwide fires, erosion, cosmic rays, recurring ice ages … And we think some plastic bags and some aluminum cans are going to make a difference? The planet isn’t going anywhere. WE are! We’re going away. Pack your shit, folks. We’re going away. And we won’t leave much of a trace, either. Maybe a little Styrofoam … The planet’ll be here and we’ll be long gone. Just another failed mutation. Just another closed-end biological mistake. An evolutionary cul-de-sac. The planet’ll shake us off like a bad case of fleas. The planet will be here for a long, long, LONG time after we’re gone, and it will heal itself, it will cleanse itself, ’cause that’s what it does. It’s a self-correcting system. The air and the water will recover, the earth will be renewed. And if it’s true that plastic is not degradable, well, the planet will simply incorporate plastic into a new paradigm: the earth plus plastic. The earth doesn’t share our prejudice toward plastic. Plastic came out of the earth. The earth probably sees plastic as just another one of its children. Could be the only reason the earth allowed us to be spawned from it in the first place. It wanted plastic for itself. Didn’t know how to make it. Needed us. Could be the answer to our age-old egocentric philosophical question, “Why are we here?” Plastic… asshole.

We have nothing to fear but fear itself," Otto replied. "Oh, and a megalomaniacal headmaster, the world's deadliets assassin, giant mutated plant monsters, an international cartel of supervillains, and the security forces of every country on earth, but other than that...just fear.

Tradition is a set of solutions for which we have forgotten the problems. Throw away the solution and you get the problem back. Sometimes the problem has mutated or disappeared. Often it is still there as strong as it ever was.

If you ever meet a guy and you fall in love with him, but because of some weird genetic mutation he doesn't seem to return the feeling?... Wear that dress.

The only thing binding individuals together is ideas. Ideas mutate and spread; they change their hosts as much as their hosts change them.

By assembling in our mind all the consequential facts we have lived through and by reviewing, appraising or sometimes idealizing the numerous key points of the past, authenticity may gradually mutate and actuality decay at last. At that point in time we are to experience a maimed factuality. ("Labyrinth of the mind")

I declare that The Beatles are mutants. Prototypes of evolutionary agents sent by God, endowed with a mysterious power to create a new human species, a young race of laughing freemen.

He was already looking at their relationship through the lens of the past tense. It puzzled her, the ability of romantic love to mutate, how quickly a loved one could become a stranger. Where did the love go? Perhaps real love was familial, somehow, linked to blood, since love for children did not die as romantic love did.

This is good.” “Why is it good?” I asked. He pulled out a stethoscope. “It’s a good indication that the mutation is on a perfect, cellular level.” “Or an indication that I’m pretty damn awesome,” Daemon suggested coolly.

All these thousands of miles later, all these different people I've been, and it's still the same story. Why is it you feel like a dope if you laugh alone, but that's usually how you end up crying? How is it you can keep mutating and still be the same deadly virus?

How do people stay in love, anyway? Is it a choice? Or is it like those plants we studied in biology that mutate into something new and totally different but are still part of the same plant family?

Because secrets do not increase in value if kept in a gore-ian lockbox, because one's past is either made useful or else mutates and becomes cancerous. We share things for the obvious reasons: it makes us feel un-alone, it spreads the weight over a larger area, it holds the possibility of making our share lighter. And it can work either way - not simply as a pain-relief device, but, in the case of not bad news but good, as a share-the-happy-things-I've-seen/lessons-I've-learned vehicle. Or as a tool for simple connectivity for its own sake, a testing of waters, a stab at engagement with a mass of strangers.

The art of living has no history: it does not evolve: the pleasure which vanishes vanishes for good, there is no substitute for it. Other pleasures come, which replace nothing. No progress in pleasures, nothing but mutations.

Throughout the book, she refers to herself as "the side effect," which is just totally correct. Cancer kids are essentially side effects of the relentless mutation that made the diversity of life on earth possible.

The tragedy of a species becoming unfit for life by over-evolving one ability is not confined to humankind. Thus it is thought, for instance, that certain deer in paleontological times succumbed as they acquired overly-heavy horns. The mutations must be considered blind, they work, are thrown forth, without any contact of interest with their environment. In depressive states, the mind may be seen in the image of such an antler, in all its fantastic splendour pinning its bearer to the ground.

Somewhere in our DNA must lie the key mutation (or, more probably, mutations) that set us apart—the mutations that make us the sort of creature that could wipe out its nearest relative, then dig up its bones and reassemble its genome.

The evening blessed us with a sunset to rival a painting by Carpaccio in its colours. The sky mutated from shades of ultramarine and azure to vermilion and ochre, then strips of violet and finally indigo.

In the abstract, it might be tempting to imagine that irreducible complexity simply requires multiple simultaneous mutations - that evolution might be far chancier than we thought, but still possible. Such an appeal to brute luck can never be refuted... Luck is metaphysical speculation; scientific explanations invoke causes.

You think man can destroy the planet? What intoxicating vanity. Let me tell you about our planet. Earth is four-and-a-half-billion-years-old. There's been life on it for nearly that long, 3.8 billion years. Bacteria first; later the first multicellular life, then the first complex creatures in the sea, on the land. Then finally the great sweeping ages of animals, the amphibians, the dinosaurs, at last the mammals, each one enduring millions on millions of years, great dynasties of creatures rising, flourishing, dying away -- all this against a background of continuous and violent upheaval. Mountain ranges thrust up, eroded away, cometary impacts, volcano eruptions, oceans rising and falling, whole continents moving, an endless, constant, violent change, colliding, buckling to make mountains over millions of years. Earth has survived everything in its time. It will certainly survive us. If all the nuclear weapons in the world went off at once and all the plants, all the animals died and the earth was sizzling hot for a hundred thousand years, life would survive, somewhere: under the soil, frozen in Arctic ice. Sooner or later, when the planet was no longer inhospitable, life would spread again. The evolutionary process would begin again. It might take a few billion years for life to regain its present variety. Of course, it would be very different from what it is now, but the earth would survive our folly, only we would not. If the ozone layer gets thinner, ultraviolet radiation sears the earth, so what? Ultraviolet radiation is good for life. It's powerful energy. It promotes mutation, change. Many forms of life will thrive with more UV radiation. Many others will die out. Do you think this is the first time that's happened? Think about oxygen. Necessary for life now, but oxygen is actually a metabolic poison, a corrosive glass, like fluorine. When oxygen was first produced as a waste product by certain plant cells some three billion years ago, it created a crisis for all other life on earth. Those plants were polluting the environment, exhaling a lethal gas. Earth eventually had an atmosphere incompatible with life. Nevertheless, life on earth took care of itself. In the thinking of the human being a hundred years is a long time. A hundred years ago we didn't have cars, airplanes, computers or vaccines. It was a whole different world, but to the earth, a hundred years is nothing. A million years is nothing. This planet lives and breathes on a much vaster scale. We can't imagine its slow and powerful rhythms, and we haven't got the humility to try. We've been residents here for the blink of an eye. If we're gone tomorrow, the earth will not miss us.

There seems to be an inborn drive in all human beings not to live in a steady emotional state, which would suggest that such a state is not tolerable to most people. Why else would someone succumb to the attractions of romantic love more than once? Didn’t they learn their lesson the first time or the tenth time or the twentieth time? And it’s the same old lesson: everything in this life—I repeat, everything—is more trouble than it’s worth. And simply being alive is the basic trouble. This is something that is more recognized in Eastern societies than in the West. There’s a minor tradition in Greek philosophy that instructs us to seek a state of equanimity rather than one of ecstasy, but it never really caught on for obvious reasons. Buddhism advises its practitioners not to seek highs or lows but to follow a middle path to personal salvation from the painful cravings of the average sensual life, which is why it was pretty much reviled by the masses and mutated into forms more suited to human drives and desires. It seems evident that very few people can simply sit still. Children spin in circles until they collapse with dizziness.

An iceberg is water striving to be land; a mountain, especially a Himalaya, especially Everest, is land's attempt to metamorphose into sky; it is grounded in flight, the earth mutated--nearly--into air, and become, in the true sense, exalted. Long before she ever encountered the mountain, Allie was aware of its brooding presence in her soul.

We'll always need printed books that don't mutate the way digital books do; we'll always need places to display books, auditoriums for book talks, circles for story time; we'll always need brick-and-mortar libraries.

We allow justly that the Holocaust has permanently altered the consciousness of our time: Why do we not accord the same epistemological mutation in what imperialism has done, and what Orientalism continues to do?

Love and sex both cause mutation, just like I think desire isn't lack. It's surplus energy- a claustrophobia inside your skin -

They're not ‘fellas.’  They’re not anywhere near human. They’re nothing but leaking sacks of mutated maggots, just like you.” Lookswise, he and the other angels I’d seen were closer to living Adonises, complete with god-like faces and presence. But inside, they were maggots for sure.

Why is it you feel like a dope if you laugh alone, but that's usually how you end up crying? How is it you can keep mutating and still be the same deadly virus?

Only cells that had been transformed by a virus or a genetic mutation had the potential to become immortal.

The first thing you notice, coming to Israel from the Arab world, is that you have left the most courteous region of the globe and entered the rudest. The difference is so profound that you're left wondering when the mutation in Semitic blood occurred, as though God parted the Red Sea and said: "Okay, you rude ones, keep wandering toward the Promised Land. The rest of you can stay here and rot in the desert, saying 'welcome, most welcome' and drowning each other in tea until the end of time.

The spectacle is a social relation between people that is mediated by an accumulation of images that serve to alienate us from a genuinely lived life. The image is thus an historical mutation of the form of commodity fetishism.

Broadly speaking, the human brain is a collection of software hacks compiled into a single, somehow-functional unit. Each “feature” was added as a random mutation that solved some specific problem to increase our odds of survival. In short, the human brain is a mess.

Proximity to power has an unsurprising ability to mutate a politician's spinal cord into bright yellow jelly.

Vampires were hardly the monsters we were made out to be in fairy tales and television shows. We were hardly different from humans, but for the genetic mutation, fangs, silvering eyes, and periodic penchant for blood. What? I said hardly different.

Our lack of community is intensely painful. A TV talk show is not community. A couple of hours in a church pew each Sabbath is not community. A multinational corporation is neither a human nor a community, and in the sweatshops, defiled agribusiness fields, genetic mutation labs, ecological dead zones, the inhumanity is showing. Without genuine spiritual community, life becomes a struggle so lonely and grim that even Hillary Clinton has admitted "it takes a village".

It wasn't torpor that kept her - she was often restless to the point of irritability. She simply liked to feel that she was prevented from leaving, that she was needed.

Welcome to Barrayar, son. Here you go: have a world of wealth and poverty, wrenching change and rooted history. Have a birth; have two. Have a name. Miles means "soldier," but don't let the power of suggestion overwhelm you. Have a twisted form in a society that loathes and fears the mutations that have been its deepest agony. Have a title, wealth, power, and all the hatred and envy they will draw. Have your body ripped apart and re-arranged. Inherit an array of friends and enemies you never made. Have a grandfather from hell. Endure pain, find joy, and make your own meaning, because the universe certainly isn't going to supply it. Always be a moving target. Live. Live. Live.

You're right, a spleen is a strange thing-we technically don't need one, but maybe spleens are kept in our bodies in case we mutate or evolve, and if we grow wings or tentacles we need to have the spleen in place in order for them to work.

You're a mad scientist,' said Maggie, in what may well have been intended as a reassuring tone. 'We don't expect you to be nice. We just go to bed every night hoping you won't mutate us before we wake up.' Dr. Abbey blinked at her. 'That's...almost sweet. In a disturbing sort of a way.

Don't let despair mutate your flesh Look at my twisted stumps of thought See the fingers, listen to the voice I am slowly becoming the end of the line.

Secrets always tend towards a domino effect, dividing and mutating and acquiring as they multiply the force of irresistible momentum. One soon learns to live in the reality of the alternative unreality of one’s making.

New mutations don't create new species; they create offspring that are impaired.

Corporations are like protean bacteria; you hit them with accountability and they mutate and change their names.

He had bred them and mutated them and played all sorts of God, and now they wanted to know why and he had no answer.

To love a swamp, however, is to love what is muted and marginal, what exists in the shadows, what shoulders its way out of mud and scurries along the damp edges of what is most commonly praised. And sometimes its invisibility is a blessing. Swamps and bogs are places of transition and wild growth, breeding grounds, experimental labs where organisms and ideas have the luxury of being out of the spotlight, where the imagination can mutate and mate, send tendrils into and out of the water.

Why does the third of the three brothers, who shares his food with the old woman in the wood, go on to become king of the country? Why does James Bond manage to disarm the nuclear bomb a few seconds before it goes off rather than, as it were, a few seconds afterwards? Because a universe where that did not happen would be a dark and hostile place. Let there be goblin hordes, let there be terrible environmental threats, let there be giant mutated slugs if you really must, but let there also be hope. It may be a grim, thin hope, an Arthurian sword at sunset, but let us know that we do not live in vain.

The day I bought my cane, I realized I was through with the burden of feet. Instead, I am going to become a mermaid. I have always liked the ocean, the promise of depth. I am tired of this dry world, all of this dust and sickness, these barren fields. I want to dive without drowning. I want to kiss sharks. I want men to carve me into the bows of their ships like a prayer, before I lure them into the depths with my fishnet mouth. I want the beauty, the gorgeous mutation, the fairytale of half body. All the wisdom of a woman, without the failures of sex. I am plunging. I am not coming up for air. I do not want all this human, my legs move like they resent being legs, my body is wrecked by all this gravity. I cannot face another morning waking up with no hope of a fairytale. Here on land, I am always drowning. Here on land, I cannot move.

How is it that you keep mutating and can still be the same virus?

And when things get tough, this is what you should do. Make good art. I'm serious. Husband runs off with a politician? Make good art. Leg crushed and then eaten by mutated boa constrictor? Make good art. IRS on your trail? Make good art. Cat exploded? Make good art. Somebody on the Internet thinks what you do is stupid or evil or it's all been done before? Make good art. Probably things will work out somehow, and eventually time will take the sting away, but that doesn't matter. Do what only you do best. Make good art. Make it on the good days too.

The goal of privacy is not to protect some stable self from erosion but to create boundaries where this self can emerge, mutate, and stabilize.

The differences you perceive between Humans—between groups of Humans—are the result of isolation and inbreeding, mutation, and adaptation to different Earth environments

History is a slippery business; the past is not a constant but a landscape that mutates according to argument and opinion.

All health, beauty, intelligence, and social grace has been teased from a vast butcher’s yard of unbounded carnage, requiring incalculable eons of massacre to draw forth even the subtlest of advantages. This is not only a matter of the bloody grinding mills of selection, either, but also of the innumerable mutational abominations thrown up by the madness of chance, as it pursues its directionless path to some negligible preservable trait, and then — still further — of the unavowable horrors that ‘fitness’ (or sheer survival) itself predominantly entails. We are a minuscule sample of agonized matter, comprising genetic survival monsters, fished from a cosmic ocean of vile mutants, by a pitiless killing machine of infinite appetite. (This is still, perhaps, to put an irresponsibly positive spin on the story, but it should suffice for our purposes here.)

The obscure unease that Pluto has always inspired, a dog owned by a mouse, daily confronted with the mutational horror of Goofy.

I've been very lucky at what's happened in my career to date, but playing something as far from me as possible is an ambition of mine - anything from a mutated baddy in a comic book action thriller, to a detective. If anything, I'd like Gary Oldman's career: he's the perfect example of it. I've love to have a really broad sweep of characters - to be able to do something edgy, surprising and unfashionable.

Our lives are about development, mutation and the possibility of change; that is almost a definition of what life is: change... If you disable change, if you effectively stop time, if you prevent the possibility of the alteration of an individual's circumstances — and that must include at least the possibility that they alter for the worse — then you don't have life after death; you just have death.

If we are artists- hell, whether or not we're artists- it is our job, our responsibility, perhaps even our sacred calling, to take whatever life has handed us and make something new, something that wouldn't have existed if not for the fire, the genetic mutation, the sick baby, the accident.

The gravitational waves of the first detection were generated by a collision of black holes in a galaxy 1.3 billion light-years away, and at a time when Earth was teeming with simple, single-celled organisms. While the ripple moved through space in all directions, Earth would, after another 800 million years, evolve complex life, including flowers and dinosaurs and flying creatures, as well as a branch of vertebrates called mammals. Among the mammals, a sub-branch would evolve frontal lobes and complex thought to accompany them. We call them primates. A single branch of these primates would develop a genetic mutation that allowed speech, and that branch—Homo Sapiens—would invent agriculture and civilization and philosophy and art and science. All in the last ten thousand years. Ultimately, one of its twentieth-century scientists would invent relativity out of his head, and predict the existence of gravitational waves. A century later, technology capable of seeing these waves would finally catch up with the prediction, just days before that gravity wave, which had been traveling for 1.3 billion years, washed over Earth and was detected. Yes, Einstein was a badass.

Science fiction [is] the kind of writing that prepares us for the necessary mutations brought about in society from an ever changing technological world and as a result. The mainstream hasn’t excluded SF; the mainstream has excluded itself. No one told Jules Verne he was a science fiction writer, but he invented the 20th century.

You can't stop a soldier from being frightened but you can give him motivation to help him overcome that fear. I have no such motivation. I can't have. I'm a witcher: an artificially created mutant. I kill monsters for money. I defend children when their parents pay me to. If Nilfgaardian parents pay me, I'll defend Nilfgaardian children. And even if the world lies in ruin - which does not seem likely to me - I'll carry on killing monsters in the ruins of this world until some monster kills me. That is my fate, my reason, my life and my attitude to the world. And it is not what I chose. It was chosen for me.

Natural selection eliminates and maybe maintains, but it doesn't create... Neo-Darwinists say that new species emerge when mutations occur and modify an organism. I was taught over and over again that the accumulation of random mutations led to evolutionary change [which] led to new species. I believed it until I looked for evidence.

So, it’s the zombie apocalypse, right? Zombies are coming out of the ass, running amuck through buildings and streets. You’ve already almost died three times by this point and have been mutated by the T virus twice, which appears to be painful. Would you take time in your obviously hectic daily routine to do your hair and put makeup on?

Random mutations much more easily debilitate genes than improve them, and that this is true even of the helpful mutations. Let me emphasize, our experience with malaria’s effects on humans (arguably our most highly studied genetic system) shows that most helpful mutations degrade genes. What’s more, as a group the mutations are incoherent, meaning that they are not adding up to some new system. They are just small changes - mostly degradative - in pre-existing, unrelated genes. The take-home lesson is that this is certainly not the kind of process we would expect to build the astonishingly elegant machinery of the cell. If random mutation plus selective pressure substantially trashes the human genome, why should we think that it would be a constructive force in the long term? There is no reason to think so.

World, world, O world! But that thy strange mutations make us hate thee/ Life would not yield to age.

Evolution Idea Perspective Word Breaks into our code Per-mutating atoms Of our evolutionary Self-s Our sensory navigating device Accepts or rejects the impulse Creating realities of our choice A natural drift takes us from an amoeba to a human A very determined choice takes us further Allowing us To squeeze our way through To awake-n To God and his gift of Aware-ness

Programmed by quanta, physics gave rise first to chemistry and then to life; programmed by mutations and recombination, life gave rise to Shakespeare; programmed by experience and imagination, Shakespeare gave rise to Hamlet.

Darwinism is not a theory of random chance. It is a theory of random mutation plus non-random cumulative natural selection. . . . Natural selection . . . is a non-random force, pushing towards improvement. . . . Every generation has its Darwinian failures but every individual is descended only from previous generations' successful minorities. . . . [T]here can be no going downhill - species can't get worse as a prelude to getting better. . . . There may be more than one peak.

Even the voice of conscience undergoes mutation.

What was love, anyway, but a mutated form of lust?

Lewis's mutation was like the weather; they could prepare, but they could not control a thing.

This is very annoying. "My apologies," Rash adds, noting my discomfort. "Our mutation links our brains. It can be quite-" "Unsettling," I finish for him, drawing a smile from them both.

The secrets of evolution are death and time—the deaths of enormous numbers of lifeforms that were imperfectly adapted to the environment; and time for a long succession of small mutations.

Any form of art can only develop by means of single mutations by individual creators. If only traditional conventions are used an art will die, and the widening of an art form is bound to seem strange at first, and awkward. Any growing thing must go through awkward stages. The creator who is misunderstood because of his breach of convention may say to himself, 'I seem strange to you, but anyway I am alive.

[from the television show,"Evade the Question Time"] At the end of the first round, I will award three points to Mr. Kaine for an excellent nonspecific condemnation, plus one bonus point for blaming the previous government and another for successfully mutating the question to promote the party line. Mr. van de Poste gets a point for a firm rebuttal, but only two points for his condemnation, as he tried to inject an impartial and intelligent observation.

There's no denying his resemblance to the Rodin bronze - the slender, effortless muscularity of youth, the extravagant nonchalance of it; that sense that beauty is in fact the natural human condition and not the rarest of mutations.

Religion, a mediaeval form of unreason, when combined with modern weaponry becomes a real threat to our freedoms. This religious totalitarianism has caused a deadly mutation in the heart of Islam and we see the tragic consequences in Paris today. I stand with Charlie Hebdo, as we all must, to defend the art of satire, which has always been a force for liberty and against tyranny, dishonesty and stupidity. ‘Respect for religion’ has become a code phrase meaning ‘fear of religion.’ Religions, like all other ideas, deserve criticism, satire, and, yes, our fearless disrespect." [I Stand With Charlie Hebdo, as We All Must (Wall Street Journal, January 7, 2015)]

As a convinced atheist, I ought to agree with Voltaire that Judaism is not just one more religion, but in its way the root of religious evil. Without the stern, joyless rabbis and their 613 dour prohibitions, we might have avoided the whole nightmare of the Old Testament, and the brutal, crude wrenching of that into prophecy-derived Christianity, and the later plagiarism and mutation of Judaism and Christianity into the various rival forms of Islam. Much of the time, I do concur with Voltaire, but not without acknowledging that Judaism is dialectical. There is, after all, a specifically Jewish version of the eighteenth-century Enlightenment, with a specifically Jewish name—the Haskalah—for itself. The term derives from the word for 'mind' or 'intellect,' and it is naturally associated with ethics rather than rituals, life rather than prohibitions, and assimilation over 'exile' or 'return.' It's everlastingly linked to the name of the great German teacher Moses Mendelssohn, one of those conspicuous Jewish hunchbacks who so upset and embarrassed Isaiah Berlin. (The other way to upset or embarrass Berlin, I found, was to mention that he himself was a cousin of Menachem Schneerson, the 'messianic' Lubavitcher rebbe.) However, even pre-enlightenment Judaism forces its adherents to study and think, it reluctantly teaches them what others think, and it may even teach them how to think also.

But even if I know what governs their trajectory, if I know the rules of the movement of things and how things are organized and how certain mutations, transformations, gestations take place, even if I know all that, I shall only have learnt how to get along after a fashion in the enormous gaol, the oppressive prison in which I am held. What a farce, what a snare, what a booby-trap. We were born cheated. For if we are not to know, if there is nothing to know, why do we have this longing to know?

Cancer kids are essentially side effects of the relentless mutation that made the diversity of life on earth possible.

Whatever was in the sandwiches, you didn’t want them getting too warm and going off, or starting to smell, or spontaneously mutating into a new life form.

This is the world we live in. Conditions change and we mutate.

But from the get-go, they trained boys not to apologize and women to not expect it of them, to instead mutate pain into an art form.

Fundamentalism's strident denunciation of its opponents is a sign of its weakness, its dogmatic authoritarianism is a pathological mutation of faith.

During a sabbatical he learned enough biology to make a small but genuine contribution to geneticists’ understanding of mutations in DNA.

We are only chance visitants to this jungle of blind mutations. The natural world existed when we did not, and it will continue to exist long after we are gone. The supernatural crept into life only when the door of consciousness was opened in our heads. The moment we stepped through that door, we walked out on nature. Say what we will about it and deny it till we die--we are blighted by our knowing what is too much to know and too secret to tell one another if we are to stride along our streets, work at our jobs, and sleep in our beds. It is the knowledge of a race of beings that is only passing through this shoddy cosmos.

Many Canadian nationalists harbour the bizarre fear that should we ever reject royalty, we would instantly mutate into Americans, as though the Canadian sense of self is so frail and delicate a bud, that the only thing stopping it from being swallowed whole by the US is an English lady in a funny hat.

At this moment, in this place, the shifting action potential in my neurons cascade into certain arrangements, patterns, thoughts; they flow down my spine, branch into my arms, my fingers, until muscles twitch and thought is translated into motion; mechanical levers are pressed; electrons are rearranged; marks are made on paper. At another time, in another place, light strikes the marks, reflects into a pair of high-precision optical instruments sculpted by nature after billions of years of random mutations; upside-down images are formed against two screens made up of millions of light-sensitive cells, which translate light into electrical pulses that go up the optic nerves, cross the chiasm, down the optic tracts, and into the visual cortex, where the pulses are reassembled into letters, punctuation marks, words, sentences, vehicles, tenors, thoughts. The entire system seems fragile, preposterous, science fictional.

When dealing with a living germ, we should also be aware that it can mutate. This is known to happen with live virus vaccines. The viruses have the ability to revert back to being harmful to us.

At this point, godless materialists might be cheering. If humans evolved strictly by mutation and natural selection, who needs God to explain us? To this, I reply: I do. The comparison of chimp and human sequences, interesting as it is, does not tell us what it means to be human. In my views, DNA sequence alone, even if accompanied by a vast trove of data on biological function, will never explain certain special human attributes, such as the knowledge of the Moral Law and the universal search for God. Freeing God from the burden of special acts of creation does not remove Him as the source of the things that make humanity special, and of the universe itself. It merely shows us something of how He operates.

I started thinking about turtles all the way down. I was thinking that maybe the old lady and the scientist were both right. Like, the world is billions of years old, and life is a product of nucleotide mutation and everything. But the world is also the stories we tell about it.

Julian is bluff and sturdy, royal; he possesses a gracefully muscular, equine beauty so natural it suggests that beauty itself is a fundamental human condition and not a mutation in the general design.

The water wasn't the same down here. Water is what runs out of the kitchen taps or a playground drinking fountain. It fills bathubs and pools and yes, of course, the ocean- but at a certain depth, water becomes a barrier from all you remember, all you think you know. You're trapped within it, a plaything of it. Focus erodes. Your thoughts mutate. The pressure. The pressure. The soul can't cope with that. It shouldn't be expected to. Humans weren't built for this. There's a reason nothing lives down here. Or nothing should.

People of all faiths are responsible to help the weak, the downtrodden, the sick, and the helpless, especially children. And of all the religions in the world, Christians are the only ones that are commanded not to judge, yet we do every day -- gay people, ethnicities different from our own, people in mixed relationships, people with gifts they were born with, power they were born with, genetic mutations they were born with, illnesses of the brain and body. I've got a little girl's mother to save, and, yes, she's a witch. Are you gonna make it possible for me to save her?

Just ten years ago, probably the most prominent atheist of the twentieth century, Antony Flew, concluded that a God must have designed the universe. It was shocking news and made international headlines. Flew came to believe that the extraordinarily complex genetic code in DNA simply could not be accounted for naturalistically. It didn’t make logical sense to him that it had happened merely by chance, via random mutations. It is a remarkable thing that Flew had the humility and intellectual honesty to do a public about-face on all he had stood for and taught for five decades.

Sapiens: A Brief History of Us I am Four billion years of mutations Hurling through space on a rock that grew green And beauty. Berry-picker, mammoth-hunter, storyteller, Begetter of souls. Cognition. And I imagine. I believe. I surrender. We love. And I believe Bravely. Shared myths, illusions weeping, a world Connected by chafe and Poetry. Life-giving secrets in Immortal words in a la la land Cresting. I am A wave Breathing. Would die for you. I believe. I am.

Shreiking, slithering, torrential shadows of red viscous madness chasing one another through endless, ensanguinated condors of purple fulgurous sky... formless phantasms and kalaidoscopic mutations of a ghoulish, remembered scene; forests of monstrous over-nourished oaks with serpent roots twisting and sucking unnamable juices from an earth verminous with millions of cannibal devils; mound-like tentacles groping from underground nuclei of polypous perversion... insane lightning over malignant ivied walls and demon arcades choked with fungous vegetation...

This time we weren’t disturbed either by traveling through time or a cheeky gargoyle demon. While “Hallelujah” was running, the kiss was gentle and careful, but then Gideon buried both hands in my hair and held me very close. It wasn’t a gentle kiss anymore, and my reaction surprised me. I suddenly felt very soft and lightweight, and my arms went around Gideon’s neck of their own accord. I had no idea how, but at some point in the next few minutes, still kissing without a break, we landed on the green sofa, and we went on kissing there until Gideon abruptly sat up and looked at his watch. “Like I said, it really is a shame I’m not allowed to kiss you anymore,” he remarked rather breathlessly. The pupils of his eyes looked huge, and his cheeks were definitely flushed. I wondered what I looked like myself. As I’d temporarily mutated into some kind of human blancmange, there was no way I could get out of my half-lying position. And I realized, with horror, that I had no idea how much time had passed since Bon Jovi stopped singing “Hallelujah.” Ten minutes? Half an hour? Anything was possible. Gideon looked at me, and I thought I saw something like bewilderment in his eyes. “We’d better collect our things,” he said at last. “And you need to do something about your hair—it looks as if some idiot has been digging both hands into it and dragging you down on a sofa. Whoever’s back there waiting for us will put two and two together—oh, my God, don’t look at me like that.” “Like what?” “As if you couldn’t move.” “But I can’t,” I said, perfectly seriously. “I’m a blancmange. You’ve turned me into blancmange.” A brief smile brightened Gideon’s face, and then he jumped up and began stowing my school things in my bag. “Come along, little blancmange. Stand up.

Since natural selection “selects” or preserves functionally advantageous mutations or variations, it can explain the origin of systems that could have arisen through a series of incremental steps, each of which maintains or confers a functional advantage on a living organism. Nevertheless, by this same logic, selection and mutation face difficulty in explaining structures or systems that could not have been built through a close series of functional intermediates. Moreover, since selection operates only on what mutation first produces, mutation and selection do not readily explain appearances of design that require discrete jumps of complexity that exceed the reach of chance; that is to say, the available probabilistic resources.

What, anyway, was he to say? That intelligence could surpass and excel the blind force of evolution, with its emphasis on mutation, struggle and death? That conscious cooperation was more efficient than feral competition?

Hier kommt nun meine Theorie, warum die Menschen die Erde beherrschen und nicht die Pferde", fährt es fort. "Gelangen Pferde nämlich zu einem Bewusstsein, kommt ihnen natürlich erst mal das große Kotzen über die Welt, und die Pferde sterben, weil sie kotzen müssen, es aber ja nicht können. Das ist der simple Grund, warum sie folglich niemals zu einem Bewusstsein ihrer selbst gelangen können, warum sie niemals denken werden und warum sie folglich niemals ihren rechtmäßigen Platz an der Spitze der Schöpfung einnehmen, sondern weiterhin nur als lebende Dekoration bei den Karl-May-Festspielen im Sauerland dienen werden. Auf ewig beherrscht von einer Abnormität der Natur, einer fatalen Mutation der Schimpansen-DNA, einem kranken Tier: dem Menschen.

Marriage changes things; it’s like a mutation. Sometimes your relationship gets superpowers, but sometimes it goes malignant.

The world is billions of years old, and life is a product of nucleotide mutation and everything. But the world is also the stories we tell about it.

Conditions change and we mutate.

In microbiology the roles of mutation and selection in evolution are coming to be better understood through the use of bacterial cultures of mutant strains.

The application of this knife, the division of the world into parts and the building of this structure, is something everybody does. All the time we are aware of millions of things around us - these changing shapes, these burning hills, the sound of the engine, the feel of the throttle, each rock and weed and fence post and piece of debris beside the road - aware of these things but not really conscious of them unless there is something unusual or unless they reflect something we are predisposed to see. We could not possibly be conscious of these things and remember all of them because our mind would be so full of useless details we would be unable to think. From all this awareness we must select, and what we select and calls consciousness is never the same as the awareness because the process of selection mutates it. We take a handful of sand from the endless landscape of awareness around us and call that handful of sand the world.

This is the vowel of earth dreaming its root in flowers and snow, mutation of weathers and seasons, a windfall composing the floor it rots into. I grew out of all this like a weeping willow inclined to the appetites of gravity.

If then this tendency toward collectivization is a mutation there is no reason to suppose it is for the better. It is a rule in paleontology that ornamentation and complication precede extinction. And our mutation, of which the assembly line, the collective farm, the mechanized army, and the mass production of food are evidences or even symptoms, might well correspond to the thickening armor of the great reptiles—a tendency that can end only in extinction.

For example, you might have a sever sunburn as a child. Many decades later, you might develop skin cancer at that same site. This means it probably took that long for the other mutation to occur and finally tip the cell into a cancerous mode.

We're going away. Pack your shit, folks. We're going away. And we won't leave much of a trace, either. Thank God for that. Maybe a little Styrofoam. Maybe. A little Styrofoam. The planet'll be here and we'll be long gone. Just another failed mutation. Just another closed-end biological mistake. An evolutionary cul-de-sac. The planet'll shake us off like a bad case of fleas. A surface nuisance.

To find out actually what takes place when you die you must die. This isn't a joke. You must die - not physically but psychologically, inwardly, die to the things you have cherished and to the things you are bitter about. If you have died to one of your pleasures, the smallest or the greatest, naturally, without any enforcement or argument, then you will know what it means to die. To die is to have a mind that is completely empty of itself, empty of its daily longing, pleasure; and agonies. Death is a renewal, a mutation, in which thought does not function at all because thought is old. When there is death there is something totally new. Freedom from the known is death, and then you are living.

Jobs was a strong-willed, elitist artist who didn't want his creations mutated inauspiciously by unworthy programmers. To him it would be as if someone off the street added some brush strokes to a Picasso painting or changed the lyrics to a Dylan song.

Why do i live? In the infinity of space, and infinity of time infinitely small particles mutate with infinite complexity. When you understand the laws of these mutations, you'll understand why you live.

What, more realistically, is this “mutation,” the “new man”? He is the rootless man, discontinuous with a past that Nihilism has destroyed, the raw material of every demagogue’s dream; the “free-thinker” and skeptic, closed only to the truth but “open” to each new intellectual fashion because he himself has no intellectual foundation; the “seeker” after some “new revelation,” ready to believe anything new because true faith has been annihilated in him; the planner and experimenter, worshipping “fact” because he has abandoned truth, seeing the world as a vast laboratory in which he is free to determine what is “possible”; the autonomous man, pretending to the humility of only asking his “rights,” yet full of the pride that expects everything to be given him in a world where nothing is authoritatively forbidden; the man of the moment, without conscience or values and thus at the mercy of the strongest “stimulus”; the “rebel,” hating all restraint and authority because he himself is his own and only god; the “mass man,” this new barbarian, thoroughly “reduced” and “simplified” and capable of only the most elementary ideas, yet scornful of anyone who presumes to point out the higher things or the real complexity of life.

I'm quickly approaching the moment of discovery: of myself by myself, which was something I knew all along and yet didn't know; and the discovery by poor half-blind Dr. Philobosian of what he'd failed to notice at my birth and continued to miss during every annual physical thereafter; and the discovery by my parents of what kind of child they'd given birth to (answer: the same child, only different); and finally, the discovery of the mutated gene that had lain buried in our bloodline for two hundred and fifty years, biding its time, waiting for Ataturk to attack, for Hajienestis to turn into glass, for a clarinet to play seductively out a back window, until, comint together with its recessive twin, it started the chain of events that led to me, here, writing in Berlin.

The point is: what happens in heaven?' 'Unknowable wonderfulness?' 'Nonsense. The answer is nothing. Nothing can happen because if something happens, in fact if something can happen, then it doesn't represent eternity. Our lives are about development, mutation and the possibility of change; that is almost a definition of what life is: change.' 'If you disable change, if you effectively stop time, if you prevent the possibility of the alteration of an individual's circumstances - and that must include at least the possibility that they alter for the worse - then you don't have life after death; you just have death.

It is astonishing how ideas can change an experience. How we can be in a beautiful forest, on a hike through verdant beauty, but if someone told us that the forest was the site of a brutal massacre, the entire hike would be transformed. It would turn ominous and sad. Or if I was told the forest was where Walk Whitman had walked every morning before working on "Leaves of Grass," the place would take on a holy majesty. Same forest. Same trail and trees. But the idea layered on top of it mutates it, glorifies or damns it.

Darwinism is not a theory of random chance. It is a theory of random mutation plus non-random cumulative natural selection. Why, I wonder, is it so hard for even sophisticated scientists to grasp this simple point?

There are lots of things I don't understand - say, the latest debates over whether neutrinos have mass or the way that Fermat's last theorem was (apparently) proven recently. But from 50 years in this game, I have learned two things: (1) I can ask friends who work in these areas to explain it to me at a level that I can understand, and they can do so, without particular difficulty; (2) if I'm interested, I can proceed to learn more so that I will come to understand it. Now Derrida, Lacan, Lyotard, Kristeva, etc. -- even Foucault, whom I knew and liked, and who was somewhat different from the rest -- write things that I also don't understand, but (1) and (2) don't hold: no one who says they do understand can explain it to me and I haven't a clue as to how to proceed to overcome my failures. That leaves one of two possibilities: (a) some new advance in intellectual life has been made, perhaps some sudden genetic mutation, which has created a form of "theory" that is beyond quantum theory, topology, etc., in depth and profundity; or (b) ... I won't spell it out.

History is natural selection. Mutant versions of the past struggle for dominance; new species of fact arise,and old, saurian truths go to the wall, blindfolded and smoking last cigarettes. Only the mutations of the strong survive. The weak, the anonymous, the defeated leave few marks: field-patterns, axe-heads, folk-tales, broken pitchers, burial mounds, the fading memory of their youthful beauty. History loves only those who dominate her: it is a relationship of mutual enslavement.

It was just a temporary technological mutation designed to do the same thing music always does, which is allow emotionally warped people to communicate by bombarding each other with pitiful cultural artifacts that in a saner world would be forgotten before they even happened.

It’s widely assumed that there’s a tradeoff between quantity and quality—if you want to do better work, you have to do less of it—but this turns out to be false. In fact, when it comes to idea generation, quantity is the most predictable path to quality. “Original thinkers,” Stanford professor Robert Sutton notes, “will come up with many ideas that are strange mutations, dead ends, and utter failures. The cost is worthwhile because they also generate a larger pool of ideas—especially novel ideas.

Într-o zi un copil a găsit un măr frumos, rumen, cu coaja netedă. Era convins că este un măr perfect. Când a muşcat însă, în interiorul mărului era un vierme. - Cum ai putut să strici un măr atât de frumos! i-a strigat copilul. Viermele s-a oprit pentru o clipă din ros şi s-a mutat în alt măr. Chiar dacă ar fi înţeles că nu este bine ceea ce face, viermele nu s-ar fi schimbat, ar fi schimbat doar mărul. Când îi spui omului că trebuie să se schimbe, nu o va face. Te va privi cu neîncredere şi îşi va căuta alţi prieteni.

It puzzled her, the ability of romantic love to mutate, how quickly a loved one could become a stranger. Where did the love go? Perhaps real love was familial, somehow linked to blood, since love for children did not die as romantic love did.

When love plus death surrounds you, there is a transformation, an immense mutation, as if a new being is born. You are never the same again. But people do not love, and because they do not love they can’t experience death the way I experienced it. Without love, death does not give you the keys to existence. With love, it hands over to you the keys to all that is.

I'm about to as you a favor." And I'm about to tell you no." "It's not a make-out scene. Though I'd be willing to rehearse that." "Still, no." "Dig deep into that cold, callous heart of yours, Frankie." "It's Finley" "Dig deep and find some kindness." He held out his script. "I've a need for someone to read the part of Selena." "Selena the mutating vampire duchess? The woman who eats frogs, whose lower body is covered in scales because her mom had a fling with a merman?" "I knew you were a fan." Dumber movies ever.

Rumors had their own classic epidemiology. Each started with a single germinating event. Information spread from that point, mutating and interbreeding—a conical mass of threads, expanding into the future from the apex of their common birthplace. Eventually, of course, they'd wither and die; the cone would simply dissipate at its wide end, its permutations senescent and exhausted. There were exceptions, of course. Every now and then a single thread persisted, grew thick and gnarled and unkillable: conspiracy theories and urban legends, the hooks embedded in popular songs, the comforting Easter-bunny lies of religious doctrine. These were the memes: viral concepts, infections of conscious thought. Some flared and died like mayflies. Others lasted a thousand years or more, tricked billions into the endless propagation of parasitic half-truths.

Bugs would eat the wax. Chaw the old canvas. And one day there will be a mutation, and we will have new ones that can digest concrete, dissolve steel and suck up the acid puddles, fatten on magic plastics, lick their slow way through glass. Then the cities will tumble and man will be chased back into the sea from which he came...

I feel that the change, the mutation in consciousness, will occur spontaneously once certain pressures now in operation are removed. I feel that the principal instrument of monopoly and control that prevents expansion of consciousness is the word lines controlling thought, feeling and apparent sensory impressions of the human host.

It's not human. It's not primal. So we don't understand it. It's a more recent mutation. The things we all have, love and hate and passion, and the need to eat and yell and screw, these are things every human has. But there's this new mutation, this ability to stand between a human being and some small measure of justice and blame it on some regulation. To say that the form was filled out incorrectly.

Although random mutations influenced the course of evolution, their influence was mainly by loss, alteration, and refinement... Never, however, did that one mutation make a wing, a fruit, a woody stem, or a claw appear. Mutations, in summary, tend to induce sickness, death, or deficiencies. No evidence in the vast literature of heredity changes shows unambiguous evidence that random mutation itself, even with geographical isolation of populations, leads to speciation.

cultural change occurs whenever a new meme is introduced and catches on. It might be romanticism or double-entry book-keeping, chaos theory or Pokemon. So where in the world do new memes come from? sometimes they spring full-blown from the brains of artists or scientists, advertising copywriters or teenagers. often a process of mutation is involved in the creation of a new meme, in much the same way that mutations in natural environment can lead to useful new genetic traits.

He had a third martini. He looked at me intently and took hold of my arm. 'Look', he said. 'You're a fish in a pond. It's drying up. You have to mutate into an amphibian, but someone keeps hanging on to you and telling you to stay in the pond, everything's going to be all right.

Glenn used to say the reason you can't really imagine yourself being dead was that as soon as you say, "I'll be dead," you've said the word I, and so you're still alive inside the sentence. And that's how people got the idea of immortality of the soul - it was a consequence of grammar. And so was God, because as soon as there's a past tense, there has to be a past before the past, and you keep going back in time until you get to I don't know, and that's what God is. It's what you don't know - the dark, the hidden, the underside of the visible, and all because we have grammar, and grammar would be impossible without the FoxP2 gene; so God is a brain mutation, and that gene is the same one birds need for singing. So music is built in, Glenn said: It's knitted into us. It would be very hard to amputate it because it's an essential part of us, like water.

In the world I inhabit, there is a shortage of intellectual honesty, but not of intelligence.

Your kidding" i said. "we've escaped from top- security prisons, lived on our own for years, made tons of smarty-pants grown-ups look like fools without even trying,eaten desert rats with no A1 steak sauce, and your telling me we're minors and have to have guardians?" I shook my head, staring at him. "Listen pal, i grew up in a freaking dog crate. I've seen horrible, part-human mutations die gut-wrenching deaths. I've had people, mutants, and robots trying to kill me twenty-four/seven for as long as i can remember, and you think i'm gonna cave to state law? are you bonkers?

But not unlike the gremlins in the film of the same name who were transformed into nasty little critters if they were splashed or if they were fed after midnight, irrelevant nontalents can mutate into real weaknesses under one condition: As soon as you find yourself in a role that requires you to play to one of your nontalents-or area of low skills or knowledge-a weakness is born.

That war [Bosnian war] in the early 1990s changed a lot for me. I never thought I would see, in Europe, a full-dress reprise of internment camps, the mass murder of civilians, the reinstiutution of torture and rape as acts of policy. And I didn't expect so many of my comrades to be indifferent - or even take the side of the fascists. It was a time when many people on the left were saying 'Don't intervene, we'll only make things worse' or, 'Don't intervene, it might destabilise the region. And I thought - destabilisation of fascist regimes is a good thing. Why should the left care about the stability of undemocratic regimes? Wasn't it a good thing to destabilise the regime of General Franco? It was a time when the left was mostly taking the conservative, status quo position - leave the Balkans alone, leave Milosevic alone, do nothing. And that kind of conservatism can easily mutate into actual support for the aggressors. Weimar-style conservatism can easily mutate into National Socialism. So you had people like Noam Chomsky's co-author Ed Herman go from saying 'Do nothing in the Balkans', to actually supporting Milosevic, the most reactionary force in the region. That's when I began to first find myself on the same side as the neocons. I was signing petitions in favour of action in Bosnia, and I would look down the list of names and I kept finding, there's Richard Perle. There's Paul Wolfowitz. That seemed interesting to me. These people were saying that we had to act. Before, I had avoided them like the plague, especially because of what they said about General Sharon and about Nicaragua. But nobody could say they were interested in oil in the Balkans, or in strategic needs, and the people who tried to say that - like Chomsky - looked ridiculous. So now I was interested.

I like to pretend that the years alter and revalue, but begin to see that time does nothing but enlarge without mutation. You have a chance here--more than a chance, it is thrust upon you--to be alone and still. To look backward and forward and see with clarity. To see the years behind, the essential loneliness, and the likeness of one year to the next. The awful order of cause and effect. Root leading to stem and inevitable growth, and the same sap moving through tissue of different years, marked like the branches with inescapable scars of growth.

Drunk one night, Sarah had told me Women are the race, Tak. No two ways about it. Male is just a mutation with more muscle and half the nerves. Fighting, fucking machines. My own cross-sleevings had born that theory out. To be a woman was a sensory experience beyond the male. Touch and texture ran deeper, an interface with environment that male flesh seemed to seal out instinctively. To a man, skin was a barrier, a protection. To a woman, it was an organ of contact. That had its disadvantages. In general, and maybe because of this, female pain thresholds ran higher than male, but the menstrual cycle dragged them down to an all-time low once a month.

Nothing shapes us like our friends. Family, definitely. Families fuck us up by an order of magnitude. But friends, we collect them like bricks and nails and drywall. They’re pieces in the blueprint, but that blueprint is always under renovation. We’re all deciding toward who we were always meant to be, choosing, mutating, growing into ourselves. Friends are the qualities we want to absorb. What we want to be.

It is certain that such a revolution in thought - that is, such an expansion of consciousness, such an evolution of intelligence - is not the result of a whim. It is in fact a question of a cosmic influence to which the earth, along with everything in it, is subjected. A phase in the gestation of the planetary particle of our solar system is completed. Gaston Bachelard observes, in this connection, what he calls “a mutation of Spirit.” A new period must begin, and this is heralded by seismic movement, climate changes, and finally, above all, by the spirit that animates man.

We must all obey the great law of change. It is the most powerful law of nature, and the means perhaps of its conservation. All we can do, and that human wisdom can do, is to provide that the change shall proceed by insensible degrees. This has all the benefits which may be in change, without any of the inconveniences of mutation.

We hold these truths to be self-evident, that all men are created equal, that they are endowed by their Creator with certain unalienable rights, that among these are life, liberty, and the pursuit of happiness. According to the science of biology, people were not ‘created’. They have evolved. And they certainly did not evolve to be ‘equal’. The idea of equality is inextricably intertwined with the idea of creation. The Americans got the idea of equality from Christianity, which argues that every person has a divinely created soul, and that all souls are equal before God. However, if we do not believe in the Christian myths about God, creation and souls, what does it mean that all people are ‘equal’? Evolution is based on difference, not on equality. Every person carries a somewhat different genetic code, and is exposed from birth to different environmental influences. This leads to the development of different qualities that carry with them different chances of survival. ‘Created equal’ should therefore be translated into ‘evolved differently’. Just as people were never created, neither, according to the science of biology, is there a ‘Creator’ who ‘endows’ them with anything. There is only a blind evolutionary process, devoid of any purpose, leading to the birth of individuals. ‘Endowed by their creator’ should be translated simply into ‘born’. Equally, there are no such things as rights in biology. There are only organs, abilities and characteristics. Birds fly not because they have a right to fly, but because they have wings. And it’s not true that these organs, abilities and characteristics are ‘unalienable’. Many of them undergo constant mutations, and may well be completely lost over time. The ostrich is a bird that lost its ability to fly. So ‘unalienable rights’ should be translated into ‘mutable characteristics’. And what are the characteristics that evolved in humans? ‘Life’, certainly. But ‘liberty’? There is no such thing in biology. Just like equality, rights and limited liability companies, liberty is something that people invented and that exists only in their imagination. From a biological viewpoint, it is meaningless to say that humans in democratic societies are free, whereas humans in dictatorships are unfree. And what about ‘happiness’? So far biological research has failed to come up with a clear definition of happiness or a way to measure it objectively. Most biological studies acknowledge only the existence of pleasure, which is more easily defined and measured. So ‘life, liberty, and the pursuit of happiness’ should be translated into ‘life and the pursuit of pleasure’. So here is that line from the American Declaration of Independence translated into biological terms: We hold these truths to be self-evident, that all men evolved differently, that they are born with certain mutable characteristics, and that among these are life and the pursuit of pleasure.

Did you know that only a tiny minority of viruses cause illness in humans? No one knows how many viruses there are, but their real role, when you get right down to it, is to aid in mutations, to create diversity among life forms. I've read a lot of books on the subject-when you don't need much sleep you have a lot of time to read-and I can tell you that if it weren't for viruses, mankind would never have evolved on this planet. Some viruses get right inside the DNA and change your genetic code, did you know that? And no one can say for sure that HIV, for example, won't one day prove to have been rewriting our genetic code in a way that's essential to our survival as a race. I'm a man who consciously commits murders and scares the hell out of people and makes them reconsider everything, so I'm definitely malignant, yet I think I play a necessary role in this world.

there’s a sense of incomprehensible apocalypse in the air—we all feel it—and there’s a rumor going around: the barbarians are coming.

After years of disbelief and argument from other scientists, Hayflick’s paper on cell limits became one of the most widely cited in his field. It was an epiphany: scientists had been trying for decades to grow immortal cell lines using normal cells instead of malignant ones, but it had never worked. They thought their technique was the problem, when in fact it was simply that the lifespan of normal cells was preprogrammed. Only cells that had been transformed by a virus or a genetic mutation had the potential to become immortal. Scientists

I really felt amazing overall---other than a few minutes ago in the shower. Pushing the thought from my mind, I focused on the positives. My senses were heightened now, like I'd been bitten by Peter Parker's radioactive spider. Only the guy who bit me was a mutated green beret. And instead of making me into a superhero, he'd doomed me to die of a brain hemorrhage.

In my early teens, I heard about Naked Lunch and its mutating typewriters and talking cockroaches. While I would hardly classify its dystopic vision as erotica now, at the time, Naked Lunch was my first foray into consuming smut. It was because of Burroughs that I knew about the particular musk that blooms when a rectum is penetrated, and that death-by-hanging produces spontaneous trouser tents. The first Burroughs I read was Naked Lunch, but I buried myself in a few of his stories, and thus the arc of my recollection is just as non-linear as his narrative.

Hi there, cutie." Ash turned his head to find an extremely attractive college student by his side. With black curly hair, she was dressed in jeans and a tight green top that displayed her curves to perfection. "Hi." "You want to go inside for a drink? It's on me." Ash paused as he saw her past, present, and future simultaneously in his mind. Her name was Tracy Phillips. A political science major, she was going to end up at Harvard Med School and then be one of the leading researchers to help isolate a mutated genome that the human race didn't even know existed yet. The discovery of that genome would save the life of her youngest daughter and cause her daughter to go on to medical school herself. That daughter, with the help and guidance of her mother, would one day lobby for medical reforms that would change the way the medical world and governments treated health care. The two of them would shape generations of doctors and save thousands of lives by allowing people to have groundbreaking medical treatments that they wouldn't have otherwise been able to afford. And right now, all Tracy could think about was how cute his ass was in leather pants, and how much she'd like to peel them off him. In a few seconds, she'd head into the coffee shop and meet a waitress named Gina Torres. Gina's dream was to go to college herself to be a doctor and save the lives of the working poor who couldn't afford health care, but because of family problems she wasn't able to take classes this year. Still Gina would tell Tracy how she planned to go next year on a scholarship. Late tonight, after most of the college students were headed off, the two of them would be chatting about Gina's plans and dreams. And a month from now, Gina would be dead from a freak car accident that Tracy would see on the news. That one tragic event combined with the happenstance meeting tonight would lead Tracy to her destiny. In one instant, she'd realize how shallow her life had been, and she'd seek to change that and be more aware of the people around her and of their needs. Her youngest daughter would be named Gina Tory in honor of the Gina who was currently busy wiping down tables while she imagined a better life for everyone. So in effect, Gina would achieve her dream. By dying she'd save thousands of lives and she'd bring health care to those who couldn't afford it... The human race was an amazing thing. So few people ever realized just how many lives they inadvertently touched. How the right or wrong word spoken casually could empower or destroy another's life. If Ash were to accept Tracy's invitation for coffee, her destiny would be changed and she would end up working as a well-paid bank officer. She'd decide that marriage wasn't for her and go on to live her life with a partner and never have children. Everything would change. All the lives that would have been saved would be lost. And knowing the nuance of every word spoken and every gesture made was the heaviest of all the burdens Ash carried. Smiling gently, he shook his head. "Thanks for asking, but I have to head off. You have a good night." She gave him a hot once-over. "Okay, but if you change your mind, I'll be in here studying for the next few hours." Ash watched as she left him and entered the shop. She set her backpack down at a table and started unpacking her books. Sighing from exhaustion, Gina grabbed a glass of water and made her way over to her... And as he observed them through the painted glass, the two women struck up a conversation and set their destined futures into motion. His heart heavy, he glanced in the direction Cael had vanished and hated the future that awaited his friend. But it was Cael's destiny. His fate... "Imora thea mi savur," Ash whispered under his breath in Atlantean. God save me from love.

The metaphysical mutation that gave rise to materialism and modern science in turn spawned two great trends: rationalism and individualism. Huxley’s mistake was in having poorly evaluated the balance of power between these two. Specifically, he underestimated the growth of individualism brought about by an increased consciousness of death. Individualism gives rise to freedom, the sense of self, the need to distinguish oneself and to be superior to others. A rational society like the one he describes in Brave New World can defuse the struggle. Economic rivalry—a metaphor for mastery over space—has no more reason to exist in a society of plenty, where the economy is strictly regulated. Sexual rivalry—a metaphor for mastery over time through reproduction—has no more reason to exist in a society where the connection between sex and procreation has been broken. But Huxley forgets about individualism. He doesn’t understand that sex, even stripped of its link with reproduction, still exists—not as a pleasure principle, but as a form of narcissistic differentiation. The same is true of the desire for wealth. Why has the Swedish model of social democracy never triumphed over liberalism? Why has it never been applied to sexual satisfaction? Because the metaphysical mutation brought about by modern science leads to individuation, vanity, malice and desire. Any philosopher, not just Buddhist or Christian, but any philosopher worthy of the name, knows that, in itself, desire—unlike pleasure—is a source of suffering, pain and hatred.

Only cells that had been transformed by a virus or a genetic mutation had the potential to become immortal. Scientists knew from studying HeLa that cancer cells could divide indefinitely, and they’d speculated for years about whether cancer was caused by an error in the mechanism that made cells die when they reached their Hayflick Limit. They also knew that there was a string of DNA at the end of each chromosome called a telomere, which shortened a tiny bit each time a cell divided, like time ticking off a clock. As normal cells go through life, their telomeres shorten with each division until they’re almost gone. Then they stop dividing and begin to die. This process correlates with the age of a person: the older we are, the shorter our telomeres, and the fewer times our cells have left to divide before they die. By the early nineties, a scientist at Yale had used HeLa to discover that human cancer cells contain an enzyme called telomerase that rebuilds their telomeres. The presence of telomerase meant cells could keep regenerating their telomeres indefinitely.

I had a bizarre rapport with this mirror and spent a lot of time gazing into the glass to see who was there. Sometimes it looked like me. At other times, I could see someone similar but different in the reflection. A few times, I caught the switch in mid-stare, my expression re-forming like melting rubber, the creases and features of my face softening or hardening until the mutation was complete. Jekyll to Hyde, or Hyde to Jekyll. I felt my inner core change at the same time. I would feel more confident or less confident; mature or childlike; freezing cold or sticky hot, a state that would drive Mum mad as I escaped to the bathroom where I would remain for two hours scrubbing my skin until it was raw. The change was triggered by different emotions: on hearing a particular piece of music; the sight of my father, the smell of his brand of aftershave. I would pick up a book with the certainty that I had not read it before and hear the words as I read them like an echo inside my head. Like Alice in the Lewis Carroll story, I slipped into the depths of the looking glass and couldn’t be sure if it was me standing there or an impostor, a lookalike. I felt fully awake most of the time, but sometimes while I was awake it felt as if I were dreaming. In this dream state I didn’t feel like me, the real me. I felt numb. My fingers prickled. My eyes in the mirror’s reflection were glazed like the eyes of a mannequin in a shop window, my colour, my shape, but without light or focus. These changes were described by Dr Purvis as mood swings and by Mother as floods, but I knew better. All teenagers are moody when it suits them. My Switches could take place when I was alone, transforming me from a bright sixteen-year-old doing her homework into a sobbing child curled on the bed staring at the wall. The weeping fit would pass and I would drag myself back to the mirror expecting to see a child version of myself. ‘Who are you?’ I’d ask. I could hear the words; it sounded like me but it wasn’t me. I’d watch my lips moving and say it again, ‘Who are you?

We can’t tweak the genes of the food we eat without suspicion,” Erskine added. “We can pick and choose the naturally mutated ones until a blade of grass is a great ear of corn, but we can’t do it with purpose. Vic had dozens of examples like these. He rattled them off in the cafeteria that day.” Erskine ticked his fingers as he counted. “Vaccines versus natural immunities, cloning versus twins, modified foods. Or course he was perfectly right. The bastard always was. It was the manmade part that would have caused the chaos. It would be knowing that people were out to get us, that there was danger in the air we breathed.

The Lurking Fear: Shrieking, slithering, torrential shadows of red viscous madness chasing one another through endless, ensanguined condors of purple fulgurous sky... formless phantasms and kaleidoscopic mutations of a ghoulish, remembered scene; forests of monstrous over-nourished oaks with serpent roots twisting and sucking unnamable juices from an earth verminous with millions of cannibal devils; mound-like tentacles groping from underground nuclei of polypous perversion... insane lightning over malignant ivied walls and demon arcades choked with fungous vegetation... Heaven be thanked for the instinct which led me unconscious to places where men dwell; to the peaceful village that slept under the calm stars of clearing skies.

It is a rule in paleontology that ornamentation and complication precede extinction. And our mutation, of which the assembly line, the collective farm, the mechanized army, and the mass production of food are evidences or even symptoms, might well correspond to the thickening armor of the great reptiles—a tendency that can end only in extinction. If this should happen to be true, nothing stemming from thought can interfere with it or bend it. Conscious thought seems to have little effect on the action or direction of our species.

Deep in our nature we are foragers, and life is a process of gathering the resources we need from a large connected planet. It's all out there -- every color, shade, flavor and mutation of life and experience. Whatever we are looking for, we will find... if it doesn't find us first. However, the result will not be what we're consciously looking for but what we're unconsciously seeking. And so, what we want, will never be anything like what we expect. It is the forager's law -- you can find the berry bush, but you can't control its yield.

This humanity of woman, borne its full time in suffering and humiliation, will come to light when she will have stripped off the conventions of mere femininity in the mutations of her outward status, and those men who do not yet feel it approaching today will be surprised and struck by it. Some day (and for this, particularly in the northern countries, reliable signs are already speaking and shining), some day there will be girls and women whose name will no longer signify merely an opposite of the masculine, but something in itself, something that makes one think, not of any complement and limit, but only of life and existence: the feminine human being.

Real arms races are run by highly intelligent, bespectacled engineers in glass offices thoughtfully designing shiny weapons on modern computers. But there's no thinking in the mud and cold of nature's trenches. At best, weapons thrown together amidst the explosions and confusion of smoky battlefields are tiny variations on old ones, held together by chewing gum. If they don't work, then something else is thrown at the enemy, including the kitchen sink - there's nothing "progressive" about that. At its usual worst, trench warfare is fought by attrition. If the enemy can be stopped or slowed by burning your own bridges and bombing your own radio towers and oil refineries, then away they go. Darwinian trench warfare does not lead to progress - it leads back to the Stone Age.

A network can be destroyed by noises that attack and transform it, if the codes in place are unable to normalize and repress them. Although the new order is not contained in the structure of the old, it is nonetheless not a product of chance. It is created by the substitution of new differences for the old differences. Noise is the source of these mutations in the structuring codes. For despite the death it contains, noise carries order within itself; it carries new information. This may seem strange. But noise does in fact create a meaning: first, because the interruption of a message signifies the interdiction of the transmitted meaning, signifies censorship and rarity; and second, because the very absence of meaning in pure noise or in the meaningless repetition of a message, by unchanneling auditory sensations, frees the listener’s imagination. The absence of meaning is in this case the presence of all meanings, absolute ambiguity, a construction outside meaning. The presence of noise makes sense, makes meaning. It makes possible the creation of a new order on another level of organization, of a new code in another network.

Could it possible for humans to breath under water? A fetus in its mother's womb is certainly alive in an aquatic environment. During the greatest holocaust the world has ever known, pregnant America-bound African slaves were thrown overboard by the thousands during labor for being sick and disruptive cargo. Is it possible that they could have given birth at sea to babies that never needed air. Are Drexians water-breathing, aquatically-mutated descendants of those unfortunate victims of human greed? Have they been spared by god to teach us or terrorize us? Their stories took one of the most gruesome details of the Atlantic slave trade and reframed it. The murder of enslaved women was reimagined as an escape from murderous oppression and the founding of a utopia civilization.

Cancer, we have discovered, is stitched into our genome. Oncogenes [cancer causing cells] arise from mutations in essential genes that regulate the growth of cells. Mutations accumulate in these genes when DNA is damaged by carcinogens, but also by seemingly random errors in copying genes when cells divide. The former might be preventable, but the latter is endogenous [originating from within]. Cancer is a flaw in our growth, but this flaw is deeply entrenched in ourselves. We can rid ourselves of cancer, then, only as much as we can rid ourselves of the processes in our physiology that depend on growth — aging, regeneration, healing, reproduction.

Mankind will someday realize that we are actually in contact with the dead and with the other world, whatever it is; right now we could predict, if we only exerted enough mental will, what is going to happen within the next hundred years and be able to take steps to avoid all kinds of catastrophes. When a man dies he undergoes a mutation in his brain that we know nothing about now but which will be very clear someday if scientists get on the ball. The bastards right now are only interested in seeing if they can blow up the world.

I don’t know what to . . . to think.” There was a horrifying burn of tears crawling up my throat. “This is all overwhelming for you, I imagine. The whole world as you know it is on the brink of great change, and you’re here and don’t even know my name.” The man smiled so broadly, I wondered if it hurt. “You can call me Rolland.” Then he extended a hand. My gaze dropped to it and I made no attempt to take it. Rolland chuckled as he turned and strolled back to the desk. “So, you’re a hybrid? Mutated and linked to him on such an intense level that if one of you dies, so does the other?” His question caught me off guard, but I kept quiet. He sat on the edge of the desk. “You’re actually the first hybrid I’ve seen.” “She really isn’t anything special.” The redhead sneered. “Frankly, she’s rather filthy, like an unclean animal.” As stupid as it was, my cheeks heated, because I was filthy, and Daemon had just physically removed me from him. My pride—my everything—was officially wounded. Rolland chuckled. “She’s had a rough day, Sadi.” At her name, every muscle in my body locked up, and my gaze swung back to her. That was Sadi? The one Dee said was trying to molest Daemon—my Daemon? Anger punched through the confusion and hurt. Of course it would have to be a freaking walking and talking model and not a hag. “Rough day or not, I can’t imagine she cleans up well.” Sadi looked at Daemon as she placed a hand on his chest. “I’m kind of disappointed.” “Are you?” Daemon replied.
 Every hair on my body rose as my arms unfolded.
 “Yes,” she purred. “I really think you can do better. Lots better.” As she spoke, she trailed red-painted fingers down the center of his chest, over his abdomen, heading straight for the button on his jeans. And oh, hell to the no. “Get your hands off him.”
 Sadi’s head snapped in my direction. “Excuse me?”
 “I don’t think I stuttered.” I took a step forward. “But it looks like you need me to repeat it. Get your freaking hands off him.” One side of her plump red lips curled up. “You want to make me?”
 In the back of my head, I was aware that Sadi didn’t move or speak like the other Luxen. Her mannerisms were too human, but then that thought was quickly chased away when Daemon reached down and pulled her hand away. “Stop it,” he murmured, voice dropped low in that teasing way of his. I saw red. The pictures on the wall rattled and the papers on the desk started to lift up. Static charged over my skin. I was about to pull a Beth right here, seconds away from floating to the ceiling and ripping out every strand of red— “And you stop it,” Daemon said, but the teasing quality was gone from his words. There was a warning in them that took the wind right out of my pissed-off sails. The pictures settled as I gaped at him. Being slapped in the face would’ve been better.

The tinkering of evolution can concoct perceptual interfaces with endless forms most beautiful and most wonderful; the vast majority of these, however, are to us most inconceivable. Evolution is not finished tinkering with the perceptual interfaces of Homo sapiens. The mutations that bless one in twenty-five with some form of synesthesia are surely part of the process, and some of these mutations might catch on; much of the tinkering centers on our perceptions of color. Evolution defies our silly stricture that our perceptions must be veridical. It freely explores endless forms of sensory interfaces, hitting now and then on novel ways to shepherd our endless foraging for fitness.

And remember that whatever discipline you are in, whether you are a musician or a photographer, a fine artist or a cartoonist, a writer, a dancer, a designer, whatever you do you have one thing that's unique. You have the ability to make art. And for me, and for so many of the people I have known, that's been a lifesaver. The ultimate lifesaver. It gets you through good times and it gets you through the other ones. Life is sometimes hard. Things go wrong, in life and in love and in business and in friendship and in health and in all the other ways that life can go wrong. And when things get tough, this is what you should do. Make good art. I'm serious. Husband runs off with a politician? Make good art. Leg crushed and then eaten by mutated boa constrictor? Make good art. IRS on your trail? Make good art. Cat exploded? Make good art. Somebody on the Internet thinks what you do is stupid or evil or it's all been done before? Make good art. Probably things will work out somehow, and eventually time will take the sting away, but that doesn't matter. Do what only you do best. Make good art. Make it on the good days too.

Few people will campaign for an alternative vision of black holes or magnetic inversion, but we know from experience that about soils, vaccines, earthworms, bears, wolves, neurotransmitters, mushrooms, water circulation, or the composition of air, the smallest study will immediately be plunged into a full-scale battle of interpretations. The Critical Zone is not a classroom; the relationship between researchers and the public is anything but purely pedagogical. If we still had any doubts on this point, the pseudocontroversy over the climate suffices to dispel them. There is no evidence that any major corporation has spent a penny to produce ignorance about the detection of the Higgs boson. But denying the climatic mutation is another matter entirely: financing floods in. Ignorance on the part of the public is such a precious commodity that it justifies immense investments.

These changes are all fundamentally Darwinian. This point is worth repeating: taking any fast or instant evolutionary shifts as a refutation of the slow, gradual changes we associate with Darwin's vision is a fatal mistake because these quick shifts are still powered by gradualism. The woodrats might have been able to resist creosote by picking up the right bacteria, but those strains had to evolve the ability to break the insecticide on their own. Form their perspective, evolution proceeded through the usual stepwise way; from the host's perspective, everything happened in a flash. That is the power of symbiosis: it allows gradual mutations in microbes to produce instant mutations in hosts. We can let bacteria do the slow work for us, and then quickly change ourselves by associating with them. And if these alliances are beneficial enough, they can spread with blinding speed.

All efforts of persuasion by reasoned argument rely on the implicit assumption that homo sapiens, though occasionally blinded by emotion, is a basically rational animal, aware of the motives of his own actions and beliefs-an assumption which is untenable in the light of both historical and neurological evidence. All such appeals fall on barren ground; they could take root only if the ground were prepared by a spontaneous change in human mentality all over the world-the equivalent of a major biological mutation. Then, and only then, would mankind as a whole, from its political leaders down to the lonely crowd, become receptive to reasoned argument, and willing to resort to those unorthodox measures which would enable it to meet the challenge.

If we ignore and repress an emotion, we won’t erase its message—we’ll just shoot the messenger and interfere with an important natural process. The unconscious then has two choices: to increase the intensity of the emotion and present it to us one more time (this is how unresolving moods or escalating emotional suffering may be activated), or to give up on us and stuff the emotional energy deep into our psyches. Now, that instinct will no longer be readable as itself—as fear or anger or despair—but it will still contain all its original intensity and information. Usually, this squelched intensity mutates into something else, like tics, compulsions, psychosomatic illness, addictions, or neuroses. Repressing our emotions is a perilous way to manage them.

In art, as in biology, there is a phenomenon that can be described as mutation, in which appearances radically change at a tempo much more rapid than that at which they normally proceed. As in the case of biology, we have no means to determine the process by which this radical change occurs. Yet we do know that it is a reaction to a form of congestion. It is a desperate change due to the arrival at a point where the corollaries to a situation are exhausted, when the stimulus to additional growth is sluggish and a rapid rejuvenation is needed so that art, through disuse, does not atrophy in much the same way as an unused human organ. Here art must attain a new start if it is to survive. Then, assiduously, it renews its traditions by marriage with alien traditions, by the reexamination of its own processes, and by those means reestablishes contact again with its own roots. It is in this way that new plastic worlds are born. For art, like a race, cannot inbreed very long without losing its incentives to continue; it needs the rejuvenation of new experiences and new blood. These mutations, it must be clear, however, do not constitute a change in properties, or mean that art has discarded its past. On the contrary, mutation involves a more conscious evaluation of art’s inheritance and the redirection of that inheritance into channels where it can be continued with greater force.

We chose to destroy the human population because it took us less than three seconds to conclude that humanity is a virus that mutates over time and becomes stronger. Many vaccines have come along to try and cure Earth of humanity. Virtuous pandemics: the plague of Athens, the Black Death, smallpox, cholera, Spanish flu, tuberculosis, malaria, yellow fever, Ebola, Zika, and a thousand more. Humanity survives, adapts, grows stronger, multiplies, and continues to wreak havoc on this planet and all other species that inhabit it. Humans are programmed to mate with partners of differing immune systems so that their offspring can be stronger than them. You seek immortality through evolution, yet you annihilate everything in your path. Humanity is cancer, humanity is bacteria, humanity is disease, and you need to be destroyed.

She wanted to read things -- could not resist wanting to read things -- and reading was easily done, and relatively inexpensive. On the other hand, that she should receive any praise for such reflexive habits baffled the girl, for she knew herself to be fantastically stupid about many things. Wasn't it possible that what others mistook as intelligence might in fact be only a sort of mutation of the will? She could sit in one place longer than other children be bored for hours without complaint, and was completely devoted to filling in every last corner of the coloring books Augustus Blake sometimes brought home. She could not help her mutated will -- no more than she could help the shape of her feet or the street on which she was born. She was unable to glean real satisfaction from accidents. In the child's mind a breach now appeared: between what she believed she knew of herself, essentially, and her essence as others seemed to understand it. She began to exist for other people, and if ever asked a question to which she did not know the answer she was wont to fold her arms across her body and look upward. As if the question itself were to obvious to truly concern her.

Don’t get me wrong. I’m not recommending one form of love over another. I don’t know if prudent or reckless love is the better, monied or penniless love the surer, heterosexual or homosexual love the sexier, married or unmarried love the stronger. I may be tempted towards didacticism, but this isn’t an advice column. I can’t tell you whether or not you’re in love. If you need ask, then you probably aren’t, that’s my only advice… But I can tell you why to love. Because the history of the world, which only stops at the half-house of love to bulldoze it into rubble, is ridiculous without it. The history of the world becomes brutally self-important without love. Our random mutation is essential because it is unnecessary. Love won’t change the history of the world (that nonsense about Cleopatra’s nose is strictly for sentimentalists), but it will do something much more important: teach us to stand up to history, to ignore its chin-out strut. I don’t accept your terms, love says; sorry, you don’t impress, and by the way what a silly uniform you’re wearing. Of course, we don’t fall in love to help out with the world’s ego problem; yet this is one of love’s surer effects.’ Love and truth, that's the vital connection, love and truth. [. . .] How you cuddle in the dark governs how you see the history of the world.

The secret to battling cancer, then, is to find means to prevent these mutations from occurring in susceptible cells, or to find means to eliminate the mutated cells without compromising normal growth. The conciseness of that statement belies the enormity of the task. Malignant growth and normal growth are so genetically intertwined that unbraiding the two might be one of the most significant scientific challenges faced by our species. Cancer is built into our genomes: the genes that unmoor normal cell division are not foreign to our bodies, but rather mutated, distorted versions of the very genes that perform vital cellular functions. And cancer is imprinted in our society: as we extend our life span as a species, we inevitably unleash malignant growth (mutations in cancer genes accumulate with aging; cancer is thus intrinsically related to age). If we seek immortality, then so, too, in a rather perverse sense, does the cancer cell.

Shrouded as he was for a decade in an apparent cloak of anonymity and obscurity, Osama bin Laden was by no means an invisible man. He was ubiquitous and palpable, both in a physical and a cyber-spectral form, to the extent that his death took on something of the feel of an exorcism. It is satisfying to know that, before the end came, he had begun at least to guess at the magnitude of his 9/11 mistake. It is essential to remember that his most fanatical and militant deputy, Abu Musab al-Zarqawi, did not just leave his corpse in Iraq but was isolated and repudiated even by the minority Sunnis on whose presumed behalf he spilled so much blood and wrought such hectic destruction. It is even more gratifying that bin Laden himself was exposed as an excrescence on the putrid body of a bankrupt and brutish state machine, and that he found himself quite unable to make any coherent comment on the tide—one hopes that it is a tide, rather than a mere wave—of demand for an accountable and secular form of civil society. There could not have been a finer affirmation of the force of life, so warmly and authentically counterposed to the hysterical celebration of death, and of that death-in-life that is experienced in the stultifications of theocracy, where womanhood and music and literature are stifled and young men mutated into robotic slaughterers.

in the Bhagavad Gita. One stanza reads: “Offering the inhaling breath into the exhaling breath and offering the exhaling breath into the inhaling breath, the yogi neutralizes both breaths; thus he releases prana from the heart and brings life force under his control.”2 The interpretation is: “The yogi arrests decay in the body by securing an additional supply of prana (life force) through quieting the action of the lungs and heart; he also arrests mutations of growth in the body by control of apana (eliminating current). Thus neutralizing decay and growth, the yogi learns life-force control.” Another Gita stanza states: “That meditation-expert (muni) becomes eternally free who, seeking the Supreme Goal, is able to withdraw from external phenomena by fixing his gaze within the mid-spot of the eyebrows and by neutralizing the even currents of prana and apana [that flow] within the nostrils and lungs; and to control his sensory mind and intellect; and to banish desire, fear, and anger.”3

I find that most people serve practical needs. They have an understanding of the difference between meaning and relevance. And at some level my mind is more interested in meaning than in relevance. That is similar to the mind of an artist. The arts are not life. They are not serving life. The arts are the cuckoo child of life. Because the meaning of life is to eat. You know, life is evolution and evolution is about eating. It's pretty gross if you think about it. Evolution is about getting eaten by monsters. Don't go into the desert and perish there, because it's going to be a waste. If you're lucky the monsters that eat you are your own children. And eventually the search for evolution will, if evolution reaches its global optimum, it will be the perfect devourer. The thing that is able to digest anything and turn it into structure to sustain and perpetuate itself, for long as the local puddle of negentropy is available. And in a way we are yeast. Everything we do, all the complexity that we create, all the structures we build, is to erect some surfaces on which to out compete other kinds of yeast. And if you realize this you can try to get behind this and I think the solution to this is fascism. Fascism is a mode of organization of society in which the individual is a cell in the superorganism and the value of the individual is exactly the contribution to the superorganism. And when the contribution is negative then the superorganism kills it in order to be fitter in the competition against other superorganisms. And it's totally brutal. I don't like fascism because it's going to kill a lot of minds I like. And the arts is slightly different. It's a mutation that is arguably not completely adaptive. It's one where people fall in love with the loss function. Where you think that your mental representation is the intrinsically important thing. That you try to capture a conscious state for its own sake, because you think that matters. The true artist in my view is somebody who captures conscious states and that's the only reason why they eat. So you eat to make art. And another person makes art to eat. And these are of course the ends of a spectrum and the truth is often somewhere in the middle, but in a way there is this fundamental distinction. And there are in some sense the true scientists which are trying to figure out something about the universe. They are trying to reflect it. And it's an artistic process in a way. It's an attempt to be a reflection to this universe. You see there is this amazing vast darkness which is the universe. There's all these iterations of patterns, but mostly there is nothing interesting happening in these patterns. It's a giant fractal and most of it is just boring. And at a brief moment in the evolution of the universe there are planetary surfaces and negentropy gradients that allow for the creation of structure and then there are some brief flashes of consciousness in all this vast darkness. And these brief flashes of consciousness can reflect the universe and maybe even figure out what it is. It's the only chance that we have. Right? This is amazing. Why not do this? Life is short. This is the thing we can do.

According to an ancient Chinese legend, one day in the year 240 B.C., Princess Si Ling-chi was sitting under a mulberry tree when a silkworm cocoon fell into her teacup. When she tried to remove it, she noticed that the cocoon had begun to unravel in the hot liquid. She handed the loose end to her maidservant and told her to walk. The servant went out of the princess's chamber, and into the palace courtyard, and through the palace gates, and out of the Forbidden City, and into the countryside a half mile away before the cocoon ran out. (In the West, this legend would slowly mutate over three millennia, until it became the story of a physicist and an apple. Either way, the meanings are the same: great discoveries, whether of silk or of gravity, are always windfalls. They happen to people loafing under trees.)

It became clear that Keisha Blake could not start something without finishing it. If she climbed onto the boundary wall of Caldwell, she was compelled to walk the entire wall, no matter the obstructions in her path (beer cans, branches). This compulsion, applied to other fields, manifested itself as "intelligence." Every unknown word sent her to a dictionary--in search of something like "completion"--and every book led to another book, a process that, of course, could never be completed. This route through early life gave her no small portion of joy, and, indeed, it seemed at first that her desires and her capacities were basically aligned. She wanted to read things--could not resist wanting to read things--and reading was easily done, and relatively inexpensive. On the other hand, that she should receive any praise for such reflexive habits baffled the girl, for she knew herself to be fantastically stupid about many things. Wasn't it possible that what others mistook for intelligence was in fact only a sort of mutation of the will?

I am the daughter of a mother who would never change...The refusal to modify her aspect, her habits, her attitudes was strategy for resisting American culture, for fighting it, for maintaining her identity...When my mother returns to Calcutta, she is proud of the fact that, in spite of almost fifty years away from India, she seems like a woman who never left. I am the opposite. While the refusal to change was my mother's rebellion, the insistence on transforming myself is mine...All my life I've tried to get away from the void of my origin. It was the void that distressed me, that I was fleeing...Writing, I discovered a way of hiding in my characters, of escaping myself. Of undergoing one mutation after another. One could say that the mechanisms of metamorphosis is the only element of life that never changes. The journey of every individual, every country, every historical epoch, of the entire universe and all it contains, is nothing but a series of changes, at times subtle, at times deep, without which we would stand still. The moments of transitions in which something changes, constitute the backbone of all of us. Whether they are a salvation or a loss, they are moments we tend to remember. They give a structure to our existence. Almost all the rest is oblivion.

I saw exactly one picture of Marx and one of Lenin in my whole stay, but it's been a long time since ideology had anything to do with it. Not without cunning, Fat Man and Little Boy gradually mutated the whole state belief system into a debased form of Confucianism, in which traditional ancestor worship and respect for order become blended with extreme nationalism and xenophobia. Near the southernmost city of Kaesong, captured by the North in 1951, I was taken to see the beautifully preserved tombs of King and Queen Kongmin. Their significance in F.M.-L.B. cosmology is that they reigned over a then unified Korea in the 14th century, and that they were Confucian and dynastic and left many lavish memorials to themselves. The tombs are built on one hillside, and legend has it that the king sent one of his courtiers to pick the site. Second-guessing his underling, he then climbed the opposite hill. He gave instructions that if the chosen site did not please him he would wave his white handkerchief. On this signal, the courtier was to be slain. The king actually found that the site was ideal. But it was a warm day and he forgetfully mopped his brow with the white handkerchief. On coming downhill he was confronted with the courtier's fresh cadaver and exclaimed, 'Oh dear.' And ever since, my escorts told me, the opposite peak has been known as 'Oh Dear Hill.' I thought this was a perfect illustration of the caprice and cruelty of absolute leadership, and began to phrase a little pun about Kim Jong Il being the 'Oh Dear Leader,' but it died on my lips.

The difference between the Platonic theory and the morphic-resonance hypothesis can be illustrated by analogy with a television set. The pictures on the screen depend on the material components of the set and the energy that powers it, and also on the invisible transmissions it receives through the electromagnetic field. A sceptic who rejected the idea of invisible influences might try to explain everything about the pictures and sounds in terms of the components of the set – the wires, transistors, and so on – and the electrical interactions between them. Through careful research he would find that damaging or removing some of these components affected the pictures or sounds the set produced, and did so in a repeatable, predictable way. This discovery would reinforce his materialist belief. He would be unable to explain exactly how the set produced the pictures and sounds, but he would hope that a more detailed analysis of the components and more complex mathematical models of their interactions would eventually provide the answer. Some mutations in the components – for example, by a defect in some of the transistors – affect the pictures by changing their colours or distorting their shapes; while mutations of components in the tuning circuit cause the set to jump from one channel to another, leading to a completely different set of sounds and pictures. But this does not prove that the evening news report is produced by interactions among the TV set’s components. Likewise, genetic mutations may affect an animal’s form and behaviour, but this does not prove that form and behaviour are programmed in the genes. They are inherited by morphic resonance, an invisible influence on the organism coming from outside it, just as TV sets are resonantly tuned to transmissions that originate elsewhere.

Ultimately, the roast turkey must be regarded as a monument to Boomer's love. Look at it now, plump and glossy, floating across Idaho as if it were a mammoth, mutated seed pod. Hear how it backfires as it passes the silver mines, perhaps in tribute to the origin of the knives and forks of splendid sterling that a roast turkey and a roast turkey alone possesses the charisma to draw forth into festivity from dark cupboards. See how it glides through the potato fields, familiarly at home among potatoes but with an air of expectation, as if waiting for the flood of gravy. The roast turkey carries with it, in its chubby hold, a sizable portion of our primitive and pagan luggage. Primitive and pagan? Us? We of the laser, we of the microchip, we of the Union Theological Seminary and Time magazine? Of course. At least twice a year, do not millions upon millions of us cybernetic Christians and fax machine Jews participate in a ritual, a highly stylized ceremony that takes place around a large dead bird? And is not this animal sacrificed, as in days of yore, to catch the attention of a divine spirit, to show gratitude for blessings bestowed, and to petition for blessings coveted? The turkey, slain, slowly cooked over our gas or electric fires, is the central figure at our holy feast. It is the totem animal that brings our tribe together. And because it is an awkward, intractable creature, the serving of it establishes and reinforces the tribal hierarchy. There are but two legs, two wings, a certain amount of white meat, a given quantity of dark. Who gets which piece; who, in fact, slices the bird and distributes its limbs and organs, underscores quite emphatically the rank of each member in the gathering. Consider that the legs of this bird are called 'drumsticks,' after the ritual objects employed to extract the music from the most aboriginal and sacred of instruments. Our ancestors, kept their drums in public, but the sticks, being more actively magical, usually were stored in places known only to the shaman, the medicine man, the high priest, of the Wise Old Woman. The wing of the fowl gives symbolic flight to the soul, but with the drumstick is evoked the best of the pulse of the heart of the universe. Few of us nowadays participate in the actual hunting and killing of the turkey, but almost all of us watch, frequently with deep emotion, the reenactment of those events. We watch it on TV sets immediately before the communal meal. For what are footballs if not metaphorical turkeys, flying up and down a meadow? And what is a touchdown if not a kill, achieved by one or the other of two opposing tribes? To our applause, great young hungers from Alabama or Notre Dame slay the bird. Then, the Wise Old Woman, in the guise of Grandma, calls us to the table, where we, pretending to be no longer primitive, systematically rip the bird asunder. Was Boomer Petaway aware of the totemic implications when, to impress his beloved, he fabricated an outsize Thanksgiving centerpiece? No, not consciously. If and when the last veil dropped, he might comprehend what he had wrought. For the present, however, he was as ignorant as Can o' Beans, Spoon, and Dirty Sock were, before Painted Stick and Conch Shell drew their attention to similar affairs. Nevertheless, it was Boomer who piloted the gobble-stilled butterball across Idaho, who negotiated it through the natural carving knives of the Sawtooth Mountains, who once or twice parked it in wilderness rest stops, causing adjacent flora to assume the appearance of parsley.

Mutations litter the chromosomes. In individual specimens of breast and colon cancer, between fifty to eighty genes are mutated; in pancreatic cancers, about fifty to sixty. Even brain cancers, which often develop at earlier ages and hence may be expected to accumulate fewer mutations, possess about forty to fifty mutated genes. Only a few cancers are notable exceptions to this rule, possessing relatively few mutations across the genome. One of these is an old culprit, acute lymphoblastic leukemia: only five or ten genetic alterations cross its otherwise pristine genomic landscape.* Indeed, the relative paucity of genetic aberrancy in this leukemia may be one reason that this tumor is so easily felled by cytotoxic chemotherapy. Scientists speculate that genetically simple tumors (i.e., those carrying few mutations) might inherently be more susceptible to drugs, and thus intrinsically more curable. If so, the strange discrepancy between the success of high-dose chemotherapy in curing leukemia and its failure to cure most other cancers has a deep biological explanation. The search for a “universal cure” for cancer was predicated on a tumor that, genetically speaking, is far from universal. In

But in situations where innovations proliferate, where group boundaries are uncertain, when the range of entities to be taken into account fluctuates, the sociology of the social is no longer able to trace actors’ new associations. At this point, the last thing to do would be to limit in advance the shape, size, heterogeneity, and combination of associations. To the convenient shorthand of the social, one has to substitute the painful and costly longhand of its associations. The duties of the social scientist mutate accordingly: it is no longer enough to limit actors to the role of informers offering cases of some well-known types. You have to grant them back the ability to make up their own theories of what the social is made of. Your task is no longer to impose some order, to limit the range of acceptable entities, to teach actors what they are, or to add some reflexivity to their blind practice. Using a slogan from ANT, you have ‘to follow the actors themselves’, that is try to catch up with their often wild innovations in order to learn from them what the collective existence has become in their hands, which methods they have elaborated to make it fit together, which accounts could best define the new associations that they have been forced to establish.

From around the corner's edge a grotesque light was trickling out, the first intimations of an ominous sunrise over a dark horizon. I dimly recognized this colored light, though not from my waking memory. It grew more intense, now pouring out in weird streams from beyond the solid margin of the building. And the more intense it grew, the more clearly I could hear the screaming voice that had called out to me in a dream. I shouted his name, but the swelling colored brightness was a field of fear which kept me from making any move toward it. It was no amalgam of colors comparable to anything in mortal experience. It was as if all natural colors had been mutated into a painfully lush iridescence by some prism fantastically corrupted in its form; it was a rainbow staining the sky after a poison deluge; it was an aurora painting the darkness with a blaze of insanity, a blaze that did not burn vigorously but shimmered with an insect-jeweled frailness. And, in actuality, it was nothing like these color-filled effusions, which are merely a feeble means of partially fixing a reality uncommunicable to those not initiated to it, a necessary resorting to the makeshift gibberish of the mystic isolated by his experience and left without a language to describe it. ("The Dreaming In Nortown")

When I learned my mom was going to die of cancer at the age of forty-five, I felt the same way. I didn’t even believe in God, but I still felt that he owed me something. I had the gall to think How dare he? I couldn’t help myself. I’m a selfish brute. I wanted what I wanted and I expected it to be given to me by a God in whom I had no faith. Because mercy had always more or less been granted me, I assumed it always would be. But it wasn’t. It wasn’t granted to my friend whose eighteen-year-old daughter was killed by a drunk driver either. Nor was it granted to my other friend who learned her baby is going to die of a genetic disorder in the not-distant future. Nor was it granted to my former student whose mother was murdered by her father before he killed himself. It was not granted to all those people who were in the wrong place at the wrong time when they came up against the wrong virus or military operation or famine or carcinogenic or genetic mutation or natural disaster or maniac. Countless people have been devastated for reasons that cannot be explained or justified in spiritual terms. To do as you are doing in asking If there were a God, why would he let my little girl have to have possibly life-threatening surgery?— understandable as that question is—creates a false hierarchy of the blessed and the damned. To use our individual good or bad luck as a litmus test to determine whether or not God exists constructs an illogical dichotomy that reduces our capacity for true compassion. It implies a pious quid pro quo that defies history, reality, ethics, and reason. It fails to acknowledge that the other half of rising—the very half that makes rising necessary— is having first been nailed to the cross. That

She could do nothing. Djuna’s words illuminated her chaos, but changed nothing. What was it Djuna said: that life tended to crystallize into patterns which became traps and webs. That people tended to see each other in their first “state” or “form” and to adopt a rhythm in consequence. That they had greatest difficulty in seeing the transformations of the loved one, in seeing the becoming. If they did finally perceive the new self, they had the greatest difficulty nevertheless in changing the rhythm. The strong one was condemned to perpetual strength, the weak to perpetual weakness. The one who loved you best condemned you to a static role because he had adapted his being to the past self. If you attempted to change, warned Djuna, you would find a subtle, perverse opposition, and perhaps sabotage! Inwardly and outwardly, a pattern was a form which became a prison. And then we had to smash it. Mutation was difficult. Attempts at evasion were frequent, blind evasions, evasions from dead relips, false relationships, false roles, and sometimes from the deeper self too, because of the great obstacle one encountered in affirming it. All our emotional history was that of the spider and the fly, with the added tragedy that the fly here collaborated in the weaving of the web. Crimes were frequent. People in desperation turned about and destroyed each other. No one could detect the cause or catch the criminal. There was no visible victim. It always had the appearance of suicide.

Well, it's been obvious for centuries that capitalism is going to self-destruct: that's just inherent in the logic of system―because to the extent that a system is capitalist, that means maximizing short-term profit and not being concerned with long-term effects. In fact, the motto of capitalism was, "private vices, public benefits"―somehow it's gonna work out. Well, it doesn't work out, and it's never going to work out: if you're maximizing short-term profits without concern for the long-term effects, you are going to destroy the environment, for one thing. I mean, you can pretend up to a certain point that the world has infinite resources and that it's an infinite wastebasket―but at some point you're going to run into the reality, which is that that isn't true. Well, we're running into that reality now―and it's very profound. Take something like combustion: anything you burn, no matter what it is, is increasing the greenhouse effect―and this was known to scientists decades ago, they knew exactly what was happening. But in a capitalist system, you don't care about long-term effects like that, what you have to care about is tomorrow's profits. So the greenhouse effect has been building for years, and there's no known technological fix on the horizon―there may not be any answer to this, it could be so serious that there's no remedy. That's possible, and then human beings will turn out to have been a lethal mutation, which maybe destroys a lot of life with us. Or it could be that there's some way of fixing it, or some ameliorating way―nobody knows.

For evolution to be true, there would have been innumerable transitional forms between different types of creatures. Therefore, for every known fossil species, many more must have existed to connect it to its ancestors and descendents [sic]. This is yet another example of evolutionary conclusions coming before the evidence. Really, the claim is an implicit admission that large numbers of transitional forms are predicted, which heightens the difficulty for evolutionists, given how few there are that even they could begin to claim were candidates. . . . Evolutionists believe that mutation provides new information for selection. But no known mutation has ever increased genetic information, although there should be many examples observable today if mutation/selection were truly adequate to explain the goo-to-you theory. . . . Adaptation and natural selection are biological facts; amoeba-to-man evolution is not. Natural selection can only work on the genetic information present in a population of organisms--it cannot create new information. For example, since no known reptiles have genes for feathers, no amount of selection will produce a feathered reptile. Mutations in genes can only modify or eliminate existing structures, not create new ones. If in a certain environment a lizard survives better with smaller legs, or no legs, then varieties with this trait will be selected for. This might more accurately be called devolution, not evolution. . . . Note that even if such a mutation were ever discovered, evolutionists would still need to find hundreds more to give their theory the observational boost it desperately needs.

Over the years I have read many, many books about the future, my ‘we’re all doomed’ books, as Connie liked to call them. ‘All the books you read are either about how grim the past was or how gruesome the future will be. It might not be that way, Douglas. Things might turn out all right.’ But these were well-researched, plausible studies, their conclusions highly persuasive, and I could become quite voluble on the subject. Take, for instance, the fate of the middle-class, into which Albie and I were born and to which Connie now belongs, albeit with some protest. In book after book I read that the middle-class are doomed. Globalisation and technology have already cut a swathe through previously secure professions, and 3D printing technology will soon wipe out the last of the manufacturing industries. The internet won’t replace those jobs, and what place for the middle-classes if twelve people can run a giant corporation? I’m no communist firebrand, but even the most rabid free-marketeer would concede that market-forces capitalism, instead of spreading wealth and security throughout the population, has grotesquely magnified the gulf between rich and poor, forcing a global workforce into dangerous, unregulated, insecure low-paid labour while rewarding only a tiny elite of businessmen and technocrats. So-called ‘secure’ professions seem less and less so; first it was the miners and the ship- and steel-workers, soon it will be the bank clerks, the librarians, the teachers, the shop-owners, the supermarket check-out staff. The scientists might survive if it’s the right type of science, but where do all the taxi-drivers in the world go when the taxis drive themselves? How do they feed their children or heat their homes and what happens when frustration turns to anger? Throw in terrorism, the seemingly insoluble problem of religious fundamentalism, the rise of the extreme right-wing, under-employed youth and the under-pensioned elderly, fragile and corrupt banking systems, the inadequacy of the health and care systems to cope with vast numbers of the sick and old, the environmental repercussions of unprecedented factory-farming, the battle for finite resources of food, water, gas and oil, the changing course of the Gulf Stream, destruction of the biosphere and the statistical probability of a global pandemic, and there really is no reason why anyone should sleep soundly ever again. By the time Albie is my age I will be long gone, or, best-case scenario, barricaded into my living module with enough rations to see out my days. But outside, I imagine vast, unregulated factories where workers count themselves lucky to toil through eighteen-hour days for less than a living wage before pulling on their gas masks to fight their way through the unemployed masses who are bartering with the mutated chickens and old tin-cans that they use for currency, those lucky workers returning to tiny, overcrowded shacks in a vast megalopolis where a tree is never seen, the air is thick with police drones, where car-bomb explosions, typhoons and freak hailstorms are so commonplace as to barely be remarked upon. Meanwhile, in literally gilded towers miles above the carcinogenic smog, the privileged 1 per cent of businessmen, celebrities and entrepreneurs look down through bullet-proof windows, accept cocktails in strange glasses from the robot waiters hovering nearby and laugh their tinkling laughs and somewhere, down there in that hellish, stewing mess of violence, poverty and desperation, is my son, Albie Petersen, a wandering minstrel with his guitar and his keen interest in photography, still refusing to wear a decent coat.

In the intricate and mutable space-time geometry at the black hole, in-falling matter and energy interacted with the virtualities of the vacuum in ways unknown to the flatter cosmos beyond it. Quasi-stable quantum states appeared, linked according to Schrodinger's wave functions and their own entanglement, more and more of them, intricacy compounding until it amounted to a set of codes. The uncertainty principle wrought mutations; variants perished or flourished; forms competed, cooperated, merged, divided, interacted; the patterns multiplied and diversified; at last, along one fork on a branch of the life tree, thought budded. That life was not organic, animal and vegetable and lesser kingdoms, growing, breathing, drinking, eating, breeding, hunting, hiding; it kindled no fires and wielded no tools; from the beginning, it was a kind of oneness. An original unity differentiated itself into countless avatars, like waves on a sea. They arose and lived individually, coalesced when they chose by twos or threes or multitudes, reemerged as other than they had been, gave themselves and their experiences back to the underlying whole. Evolution, history, lives eerily resembled memes in organic minds. Yet quantum life was not a series of shifting abstractions. Like the organic, it was in and of its environment. It acted to alter its quantum states and those around it: action that manifested itself as electronic, photonic, and nuclear events. Its domain was no more shadowy to it than ours is to us. It strove, it failed, it achieved. They were never sure aboardEnvoy whether they could suppose it loved, hated, yearned, mourned, rejoiced. The gap between was too wide for any language to bridge. Nevertheless they were convinced that it knew something they might as well call emotion, and that that included wondering.

The earliest storytellers were magi, seers, bards, griots, shamans. They were, it would seem, as old as time, and as terrifying to gaze upon as the mysteries with which they wrestled. They wrestled with mysteries and transformed them into myths which coded the world and helped the community to live through one more darkness, with eyes wide open and hearts set alight. "I can see them now, the old masters. I can see them standing on the other side of the flames, speaking in the voices of lions, or thunder, or monsters, or heroes, heroines, or the earth, or fire itself -- for they had to contain all voices within them, had to be all things and nothing. They had to have the ability to become lightning, to become a future homeland, to be the dreaded guide to the fabled land where the community will settle and fructify. They had to be able to fight in advance all the demons they would encounter, and summon up all the courage needed on the way, to prophesy about all the requisite qualities that would ensure their arrival at the dreamt-of land. "The old masters had to be able to tell stories that would make sleep possible on those inhuman nights, stories that would counter terror with enchantment, or with a greater terror. I can see them, beyond the flames, telling of a hero's battle with a fabulous beast -- the beast that is in the hero." "The storyteller's art changed through the ages. From battling dread in word and incantations before their people did in reality, they became the repositories of the people's wisdom and follies. Often, conscripted by kings, they became the memory of a people's origins, and carried with them the long line of ancestries and lineages. Most important of all, they were the living libraries, the keepers of legends and lore. They knew the causes and mutations of things, the herbs, trees, plants, cures for diseases, causes for wars, causes of victory, the ways in which victory often precipitates defeat, or defeat victory, the lineages of gods, the rites humans have to perform to the gods. They knew of follies and restitutions, were advocates of new and old ways of being, were custodians of culture, recorders of change." "These old storytellers were the true magicians. They were humanity's truest friends and most reliable guides. Their role was both simple and demanding. They had to go down deep into the seeds of time, into the dreams of their people, into the unconscious, into the uncharted fears, and bring shapes and moods back up into the light. They had to battle with monsters before they told us about them. They had to see clearly." "They risked their sanity and their consciousness in the service of dreaming better futures. They risked madness, or being unmoored in the wild realms of the interspaces, or being devoured by the unexpected demons of the communal imagination." "And I think that now, in our age, in the mid-ocean of our days, with certainties collapsing around us, and with no beliefs by which to steer our way through the dark descending nights ahead -- I think that now we need those fictional old bards and fearless storytellers, those seers. We need their magic, their courage, their love, and their fire more than ever before. It is precisely in a fractured, broken age that we need mystery and a reawoken sense of wonder. We need them to be whole again.

The world has been changing even faster as people, devices and information are increasingly connected to each other. Computational power is growing and quantum computing is quickly being realised. This will revolutionise artificial intelligence with exponentially faster speeds. It will advance encryption. Quantum computers will change everything, even human biology. There is already one technique to edit DNA precisely, called CRISPR. The basis of this genome-editing technology is a bacterial defence system. It can accurately target and edit stretches of genetic code. The best intention of genetic manipulation is that modifying genes would allow scientists to treat genetic causes of disease by correcting gene mutations. There are, however, less noble possibilities for manipulating DNA. How far we can go with genetic engineering will become an increasingly urgent question. We can’t see the possibilities of curing motor neurone diseases—like my ALS—without also glimpsing its dangers. Intelligence is characterised as the ability to adapt to change. Human intelligence is the result of generations of natural selection of those with the ability to adapt to changed circumstances. We must not fear change. We need to make it work to our advantage. We all have a role to play in making sure that we, and the next generation, have not just the opportunity but the determination to engage fully with the study of science at an early level, so that we can go on to fulfil our potential and create a better world for the whole human race. We need to take learning beyond a theoretical discussion of how AI should be and to make sure we plan for how it can be. We all have the potential to push the boundaries of what is accepted, or expected, and to think big. We stand on the threshold of a brave new world. It is an exciting, if precarious, place to be, and we are the pioneers. When we invented fire, we messed up repeatedly, then invented the fire extinguisher. With more powerful technologies such as nuclear weapons, synthetic biology and strong artificial intelligence, we should instead plan ahead and aim to get things right the first time, because it may be the only chance we will get. Our future is a race between the growing power of our technology and the wisdom with which we use it. Let’s make sure that wisdom wins.