Molecular Medicine Quotes

They remained imprisoned in the CICU, kept alive in physicality by mechanical devices and medicinal support, inexorably suffering. I revered their resiliency, though I struggled to understand whether they were truly resilient or if this was a descriptive term I used to assure myself that what we were doing was just. Could they merely represent physical beings at this point, molecular derivatives of carbon and water, void of souls that had moved on months prior once the universe had delivered their inevitable fate, simply kept alive by us physicians, who ourselves clutched desperately to the most favored of our prehistoric binary measures of success: life?

It is my belief that the basic knowledge that we're providing to the world will have a profound impact on the human condition and the treatments for disease and our view of our place on the biological continuum.

Every disease that’s with us is caused by DNA. And every disease can be fixed by DNA.

Every disease that’s with us is caused by DNA. And every disease can be fixed by DNA.

Food isn’t just generic energy—it’s molecular information. In addition to fueling the mitochondrial powerhouses, food tells our cells what to do and serves as building blocks for hormones, brain chemicals, and cell membranes.

But in the last century or so, the culture of medicine has largely been shaped by an exuberant overemphasis on the biologic and molecular phenomena of disease. Improving the social conditions that shape health has become an afterthought.

Movement is big medicine; it’s the signal to every cell in our bodies that no matter what kind of damage we’ve suffered, we’re ready to rebuild and move away from death and back toward life. Rest too long after an injury and your system powers down, preparing you for a peaceful exit. Fight your way back to your feet, however, and you trigger that magical ON switch that speeds healing hormones to everything you need to get stronger: your bones, brain, organs, ligaments, immune system, even the digestive bacteria in your belly, all get a molecular upgrade from exercise. For

Unlike an antibody, a gunslinging sheriff itching for a showdown with a gang of molecular criminals in the center of town, a T cell is the gumshoe detective going door to door to look for perpetrators hiding inside.

Movement is big medicine; it’s the signal to every cell in our bodies that no matter what kind of damage we’ve suffered, we’re ready to rebuild and move away from death and back toward life. Rest too long after an injury and your system powers down, preparing you for a peaceful exit. Fight your way back to your feet, however, and you trigger that magical ON switch that speeds healing hormones to everything you need to get stronger: your bones, brain, organs, ligaments, immune system, even the digestive bacteria in your belly, all get a molecular upgrade from exercise.

In molecular herbalism, symptoms are commonly seen as the enemy, and health is defined as the absence of symptoms. Plants are thought to be effective against certain symptoms or diseases, rather than being seen in their specificity for different types of people and patterns of imbalance.

In the above examples, a sample of the tumor (e.g., biopsy) is tested to determine the molecular signature. Testing may be by genetic sequence tests (e.g., for BCR-ABL, mutated EGFR, or HER2 gene amplification) or tissue protein stains (e.g., for the presence of ER/PR receptors or HER2 protein overexpression). The results of the testing will guide the choice of treatment—it will be personalized for the individual.

Rest too long after an injury and your system powers down, preparing you for a peaceful exit. Fight your way back to your feet, however, and you trigger that magical ON switch that speeds healing hormones to everything you need to get stronger: your bones, brain, organs, ligaments, immune system, even the digestive bacteria in your belly, all get a molecular upgrade from exercise. For that, you can thank your hunter-gatherer ancestors, who evolved to stay alive by staying on the move. Today, movement-as-medicine is a biological truth for survivors of cancer, surgery, strokes, heart attacks, diabetes, brain injuries, depression, you name it.

In network models of the interactome, these truncating mutations can be thought of as the removal of one node along with all its edges - a node removal. Nonconservative missense mutations of amino acids in the protein core that lead to major folding problems, protein aggregation, and premature protein degradation can also be modeled as node removals. At the other end of the mutational spectrum are small in-frame indels or missense mutations. These can preserve protein folding, but may modify the active site of an enzyme or affect the binding to another protein or macromolecule. In network models, these mutations, which specifically perturb a single molecular interaction, have been labeled as edge-specific or "edgetic". While investigation of the precise interaction defects associated with point mutations is of course not new, the term edgetic promotes a subtle yet meaningful archetype shift from conventional gene-centered models, which emphasize consideration of which specific edges are affected by a mutation, complement and extend classic gene-centric models, which ascertain only whether a gene product is present or not present and neglect less overt alterations of a given gene or gene product.

Autoimmune Disease—the “Leak” in Your Gut Autoimmune diseases are a disaster and there are no good medicines available (steroids work, but the treatment is worse than the disease). They’ve been around for centuries, but there’s been a clear uptick in the last fifty years. Why? Two hypotheses have been proffered to explain it: the barrier hypothesis (our skin or lungs are letting in antigens) and the hygiene hypothesis (we don’t eat dirt and are too hygienic). But in fact, in the gut, they’re the same thing; because the gut is the dirtiest place in the world—one hundred trillion bacteria to have to fend off at all times—you don’t need an intestine, you need a fortress. We’ve known for a while that leaky gut is akin to chinks in the walls of that fortress. Antigens, like enemy soldiers, escape through those chinks into the bloodstream, where T cells and antibodies react against them. But in a case of mistaken identity, these immune cells then accidentally identify parts of your body as foreign invaders and generate an immune response to kill them off, a process termed molecular mimicry. Then there are two new twists. First, it appears that one autoimmune disease, called ankylosing spondylitis, produces antibodies to a gut bacterium called Klebsiella pneumoniae. Conversely, a different autoimmune disease called rheumatoid arthritis produces antibodies to a second gut bacterium called Proteus mirabilis. Now, this might not seem that earth-shattering, but recent work has shown that the refined carbohydrates in processed food feed those two bacteria in particular, and that carbohydrate restriction improves both of these diseases. Indeed, a low-sugar, high-fiber Mediterranean diet has been shown to be efficacious at prevention and treatment of rheumatoid arthritis. Furthermore, introduction of fiber to the diet appears to improve asthma (frequently an autoimmune disease), likely by improving gut function and reducing inflammation.

Aging and dying are still enigmatic on the molecular scale to modern sciences. However, Avicenna had the broad concept figured out, and his explanation is congruent with our recent knowledge, and with new facts at hand we now can explain his reasoning at the cellular and biochemical levels. Avicenna states, “After the period of youth heat starts to diminish due to the decline in moisture, and in agreement with the internal innate heat and support of physical and psychological actions that are needed, therefore, in the absence of a natural reversal, all bodily functions reach their end

it is appropriate to quote Gruner, who wrote, “Advances of modern sciences in molecular biology, biochemistry, physiology, and pharmacology have not replaced or diminished the basic tenets of Avicenna’s system; to the contrary, they have revealed to us the need to explain them in light of the new knowledge and find a way to reconcile the two.

Personalized medicine, which we will also call molecular medicine, is the antithesis of magical thinking. It is driven by the conviction that every ailment you have has a cause at the molecular level and that once you understand the cause of your disorder, an appropriate molecular-level

If you deprive cholesterol from the brain, then you directly affect the machinery that triggers the release of neurotransmitters. Neurotransmitters affect the data-processing and memory functions. In other words—how smart you are and how well you remember things. If you try to lower the cholesterol by taking medication that is attacking the machinery of cholesterol synthesis in the liver, that medicine goes to the brain too. And then it reduces the synthesis of cholesterol, which is necessary in the brain. Our study shows there is a direct link between cholesterol and the neurotransmitter release, and we know exactly the molecular mechanics of what happens in the cells. Cholesterol changes the shape of the proteins to stimulate thinking and memory.

Quantum information, wave physics, and field communications express the thought that through the past century we have been moving from a world of solids and masses to a world of emptiness and information: there is nothing molecular in Internet communication.

Helmholtz was one of the last truly universal scientists. He made significant contributions to medicine, biology, and physics, in areas as diverse as heat in animals, irritability, the vital force, thermodynamics, electro dynamics, the conservation of energy, turbulence in liquids, and the physiology of the senses. His insights were groundbreaking, and most have withstood the test of time.

As we have seen, enzymes are minute but powerful molecular machines, machines that carry out various sorts of chemistry at phenomenal speed and with extraordinary accuracy. Chapter 1 closed with a quotation from Frederick Gowland Hopkins, who suggested almost ninety years ago that it was ‘difficult to exaggerate the importance to biology, and to chemistry no less, of extended studies of enzymes and their action’. A prophetic statement indeed, but even Hopkins could not have dreamt of the sweeping impact of these amazing molecules on science, technology, medicine, and our understanding of life itself.

Closely allied with the contribution of chemists to the alleviation of disease is their involvement at a molecular level. Biology became chemistry half a century ago when the structure of DNA was discovered (in 1953). Molecular biology, which in large measure has sprung from that discovery, is chemistry applied to the functioning of organisms. Chemists, often disguised as molecular biologists, have opened the door to understanding life and its principal characteristic, inheritance, at a most fundamental level, and have thereby opened up great regions of the molecular world to rational investigation. They have also transformed forensic medicine, brought criminals to justice, and transformed anthropology.

Our breath is atomic medicine Water is molecular medicine Earth is medicine of magnetism Sky is the medicine for optimism And with fire achieve everything you desire Get naturalized... get #Mickeymized!

What triggers the split? The cause of cell division or what causes cells to divide remains one of the most fundamental, unsolved problems in biology. Allow me to state that truth is simple. This may come as a shock to my colleagues in physics and molecular biology. So best to sit down with a glass of vino but not too long for a sedentary life is unhealthy as we all know. Lest not get distracted however and stick with the cause of cell division. Truth is that 'there is no such thing as cell division'. 'There is only one cell which veils itself so not to be itself.' In fact; I would like to argue that 'there is only one self which veils itself so not to be by itself. Without veiling oneself self could not experience companionship itself and companionship is what self is all about. It is not good for one to be alone. One's very own purpose it is companionship more commonly known as love.' The above ties in nicely with the theory of evolution (which means love in action) and the theory of relativity (time is the result of one not wanting to be alone) to name just a few. Simplified? We are not as divided as it appears. The meaning of life is love.

We will continue to concentrate our energies entirely on prescription medicines and in vitro diagnostics, rather than diversify into other sectors like generics and biosimilars, over-the-counter medicines and medical devices.” ■ “With our in-house combination of pharmaceuticals and diagnostics, we are uniquely positioned to deliver personalized healthcare.” ■ “Our distinctiveness rests on four key elements: an exceptionally broad and deep understanding of molecular biology, the seamless integration of our pharmaceuticals and diagnostics capabilities, a diversity of approaches to maximise innovation, and a long-term orientation.” ■ “Our structure is built for innovation. Our autonomous research and development centres and alliances with over 200 external partners foster diversity and agility. Our global geographical scale and reach enables us to bring our diagnostics and medicines quickly to people who need them.

imagine that your DNA is like a piano buried deep in your cells. The keys on the piano are your genes, which can be played in a variety of ways. Some keys will never be pressed. Others will be struck frequently and in steady combinations. Part of what distinguishes me from you and you from everyone else in the world is how these keys are pressed. That’s gene expression. It’s the genetic recital within your cells that plays a role in forming how your body and mind work. Our inner voice, it turns out, likes to tickle our genetic ivories. The way we talk to ourselves can influence which keys get played. The UCLA professor of medicine Steve Cole has spent his career studying how nature and nurture collide in our cells. Over the course of numerous studies he and his colleagues discovered that experiencing chatter-fueled chronic threat influences how our genes are expressed. When our internal conversations activate our threat system frequently over time, they send messages to our cells that trigger the expression of inflammation genes, which are meant to protect us in the short term but cause harm in the long term. At the same time, the cells carrying out normal daily functions, like warding off viral pathogens, are suppressed, opening the way for illnesses and infections. Cole calls this effect of chatter “death at the molecular level.

Multitasking, when it comes to paying attention, is a myth,”8 according to John Medina, a molecular biologist at the University of Washington School of Medicine. Medina acknowledges that the brain does multitask at some level—you can walk and talk at the same time. But when it comes to the brain’s ability to pay attention to a lecture, conversation, or presentation, it is simply incapable of paying equal attention to multiple items. “To put it bluntly, research shows that we can’t multitask. We are biologically incapable of processing attention-rich inputs simultaneously.

Much of medicine, in other words, is still in the rule-of-thumb era, and when new rules of thumb are discovered there is indeed more incentive for specialization. But as medical and biochemical research comes up with deeper explanations of disease processes (and healthy processes) in the body, understanding is also on the increase. More general concepts are replacing more specific ones as common, underlying molecular mechanisms are found for dissimilar diseases in different parts of the body. Once a disease can be understood as fitting into a general framework, the role of the specialist diminishes. Instead, physicians coming across an unfamiliar disease or a rare complication can rely increasingly on explanatory theories. They can look up such facts as are known. But then they may be able to apply a general theory to work out the required treatment, and expect it to be effective even if it has never been used before.

Vast quantities of government money went into research and development of drugs and food founded on chemistry and mass production. Regulations changed to support corporations and eliminate herbs. At the same time, there was a fundamental change in medicine. Drugs became molecularly specific weapons directed against germs or specific molecular lesions. Herbs, suited to general physiological imbalances, no longer fit the prevailing view of the human body.

Francis Crick477 was a British molecular biologist and co-discoverer with James Watson478 of the structure of DNA, for which he received the 1962 Nobel Prize in Physiology and Medicine. Mr. Crick was a militant atheist, a Christianophobe,479 and in favor of eugenics,480 an idea that he blamed religion for delaying (and on that point, he may have been right). He recognized the impossibility of DNA being produced by chance, and since he considered some intelligent cause necessary for it, he proposed his famous hypothesis of “panspermia,” which came to mean that life on Earth was sown by intelligent extraterrestrials. Yes, you read that correctly, by extraterrestrials.

Movement is big medicine; it’s the signal to every cell in our bodies that no matter what kind of damage we’ve suffered, we’re ready to rebuild and move away from death and back toward life. Rest too long after an injury and your system powers down, preparing you for a peaceful exit. Fight your way back to your feet, however, and you trigger that magical ON switch that speeds healing hormones to everything you need to get stronger: your bones, brain, organs, ligaments, immune system, even the digestive bacteria in your belly, all get a molecular upgrade from exercise. For that,

We are incredibly and uniquely designed with capabilities and qualities that only a Master Designer could have envisioned and incorporated into the molecular blueprint of our DNA.

The potential utility of therapeutic gene editing goes far beyond simply reverting mutated genes back to their healthy states. Some scientists are employing CRISPR in human cells to block viral infections, just like this molecular defense system naturally evolved to do in bacteria. In fact, the first clinical trials to use gene editing are aimed at curing HIV/AIDS by editing a patient’s own immune cells so the virus can’t penetrate them. And in another landmark effort, the first human life was saved by gene editing in combination with another emerging breakthrough in medicine: cancer immunotherapy, in which the body’s own immune system is trained to hunt down and kill cancerous cells.

Terminology and classification Leukaemias are traditionally classified into four main groups: • acute lymphoblastic leukaemia (ALL) • acute myeloid leukaemia (AML) • chronic lymphocytic leukaemia (CLL) • chronic myeloid leukaemia (CML). In acute leukaemia there is proliferation of primitive stem cells leading to an accumulation of blasts, predominantly in the bone marrow, which causes bone marrow failure. In chronic leukaemia the malignant clone is able to differentiate, resulting in an accumulation of more mature cells. Lymphocytic and lymphoblastic cells are those derived from the lymphoid stem cell (B cells and T cells). Myeloid refers to the other lineages, i.e. precursors of red cells, granulocytes, monocytes and platelets (see Fig. 24.2, p. 989). The diagnosis of leukaemia is usually suspected from an abnormal blood count, often a raised white count, and is confirmed by examination of the bone marrow. This includes the morphology of the abnormal cells, analysis of cell surface markers (immunophenotyping), clone-specific chromosome abnormalities and molecular changes. These results are incorporated in the World Health Organization (WHO) classification of tumours of haematopoietic and lymphoid tissues; the subclassification of acute leukaemias is shown in Box 24.47. The features in the bone marrow not only provide an accurate diagnosis but also give valuable prognostic information, allowing therapy to be tailored to the patient’s disease.

Professor of Biophysics at Iowa State University Dr. Yeon-Kyun Shin is a noted authority on how cholesterol functions within neural networks to transmit messages. He put it bluntly in an interview for a ScienceDaily reporter:28 If you deprive cholesterol from the brain, then you directly affect the machinery that triggers the release of neurotransmitters. Neurotransmitters affect the data-processing and memory functions. In other words—how smart you are and how well you remember things. If you try to lower the cholesterol by taking medication that is attacking the machinery of cholesterol synthesis in the liver, that medicine goes to the brain too. And then it reduces the synthesis of cholesterol, which is necessary in the brain. Our study shows there is a direct link between cholesterol and the neurotransmitter release, and we know exactly the molecular mechanics of what happens in the cells. Cholesterol changes the shape of the proteins to stimulate thinking and memory.

bacteria are cells, and viruses are not — which makes a big difference when it comes to medicine. Antibiotics target bacterial cells, and they don't work on viruses!

Omega-3 optimizer: SmartPrime-Om: With his partners, Dr. Lopez has leveraged artificial intelligence to identify a cocktail of methylation pathway nutrients and plant-based bioactive ingredients found in sesame seed oil extract that can expand the benefits of fish oil and increase activity of genes and enzymes responsible for increasing the body’s “pool” of omega-3s like DHA, DPA, and EPA. SmartPrime-Om also promotes delivery of omega-3s in the ideal biochemical phospholipid package to increase benefits for most cells, tissues, and major organs. 8. 23Vitals for nutraceutical immune optimization was formulated to shore up our bodies on a molecular level and rejuvenate our immune system. It contains 23 bioactive ingredients, covering more than fifty human clinical trials showing immune system bolstering, and other ingredients to support our digestive tract, respiratory, and cardiovascular health, and muscle and joint recovery from exercise stress. It’s designed to promote a healthy immune response when we need to fight off a challenge, and then tone down inflammation once the threat has been neutralized and the “wave” has receded. Available in a ready-to-mix powder. I use this personally, and am also an investor in the company.

HDL is amazing. If you do whatever it takes to get your HDL level up and functional (no drugs allowed here), you probably won’t get sick. It is about as close as the body comes to having a molecular fairy godmother that can fix everything. It alone is that powerful. HDL is built

The molecular basis of memory and learning, the discovery of which earned Kandel a share of the 2000 Nobel Prize in physiology or medicine, stands as one of the best understood of the changes the brain undergoes. It is one of the mechanisms that underlie the plasticity of the developing brain. Changes in how an organism interacts with its environment result in changes in connectivity.

What is life - life is not merely the functional expression of protoplasmic substance - it is the functional expression of protoplasmic substance that holds unimaginable potential for growth and progress.

Does medicine still need breakthroughs? Is research still worth doing? Medicine should try its utmost to prevent premature mortality; I would arbitrarily set this as anything below eighty. More importantly, medicine should deal better with pain, suffering and disability. I do not believe, however, that better ways of relieving suffering will emerge from molecular medicine.