Mitochondria Quotes

We all come into existence as a single cell, smaller than a speck of dust. Much smaller. Divide. Multiply. Add and subtract. Matter changes hands, atoms flow in and out, molecules pivot, proteins stitch together, mitochondria send out their oxidative dictates; we begin as a microscopic electrical swarm. The lungs the brain the heart. Forty weeks later, six trillion cells get crushed in the vise of our mother’s birth canal and we howl. Then the world starts in on us.

However, there is a way to know for certain that Noah’s Flood and the Creation story never happened: by looking at our mitochondrial DNA (mtDNA).  Mitochondria are the “cellular power plants” found in all of our cells and they have their own DNA which is separate from that found in the nucleus of the cell.  In humans, and most other species that mitochondria are found in, the father’s mtDNA normally does not contribute to the child’s mtDNA; the child normally inherits its mtDNA exclusively from its mother.  This means that if no one’s genes have mutated, then we all have the same mtDNA as our brothers and sisters and the same mtDNA as the children of our mother’s sisters, etc. This pattern of inheritance makes it possible to rule out “population bottlenecks” in our species’ history.  A bottleneck is basically a time when the population of a species dwindled to low numbers.  For humans, this means that every person born after a bottleneck can only have the mtDNA or a mutation of the mtDNA of the women who survived the bottleneck. This doesn’t mean that mtDNA can tell us when a bottleneck happened, but it can tell us when one didn’t happen because we know that mtDNA has a rate of approximately one mutation every 3,500 years (Gibbons 1998; Soares et al 2009). So if the human race were actually less than 6,000 years old and/or “everything on earth that breathed died” (Genesis 7:22) less than 6,000 years ago, which would be the case if the story of Adam and the story of Noah’s flood were true respectively, then every person should have the exact same mtDNA except for one or two mutations.  This, however, is not the case as human mtDNA is much more diverse (Endicott et al 2009), so we can know for a fact that the story of Adam and Eve and the story of Noah are fictional.   There

Radical feminists and evolutionists agree that males are a serious cost to society.

Your 40 trillion cells contain at least a quadrillion mitochondria, with a combined convoluted surface area of about 14,000 square metres; about four football fields.

This was it. Kiyomi realized it now. This was what her heart had reacted to. Her heart thrilled to mitochondria. But why?

Some ancient eukaryote swallowed a photosynthesizing bacteria and became a sunlight gathering alga. Millions of years later one of these algae was devoured by a second eukaryote. This new host gutted the alga, casting away its nucleus and its mitochondria, keeping only the chloroplast. That thief of a thief was the ancestor or Plasmodium and Toxoplasma. And this Russian-doll sequence of events explains why you can cure malaria with an antibiotic that kills bacteria: because Plasmodium has a former bacterium inside it doing some vital business.

Without programmed cell death, the bonds that bind cells in complex multicellular organisms might never have evolved.

Cooks were the mitochondria of humanity; they had their own separate DNA, they floated in a cell and powered it but were not really of it.

It seems that all eukaryotic cells either have, or once had (and then lost) mitochondria. In other words, possession of mitochondria is a sine qua non of the eukaryotic condition

My mitochondria comprise a very large proportion of me. I cannot do the calculation, but I suppose there is almost as much of them in sheer dry bulk as there is the rest of me. Looked at in this way, I could be taken for a very large, motile colony of respiring bacteria, operating a complex system of nuclei, microtubules, and neurons for the pleasure and sustenance of their families, and running, at the moment, a typewriter.

When the stars imploded billions of years ago, iron and silver, gold and carbon came raining down. And the iron from that stardust is in us today-in our mitochondria. Mothers pass on the stars and their iron to their children. Who knows, Jean, you and I might be made of the dust from one and the same star, and maybe we recognized each other by its light. We were searching for each other. We are star seekers.

I try to think up material that might apply to the subjects they are studying. How many mitochondria does it take to power a cell? One. Because mitochondria are the powerhouse of the cell. Not ready for prime time, that one.

Do human cells have “drivers” making the cells stop and go? It turns out that they do. The drivers of human cells, and human metabolism, are called mitochondria. And they are the common pathway to mental and metabolic disorders

Optimism More and more I have come to admire resilience. Not the simple resistance of a pillow, whose foam returns over and over to the same shape, but the sinuous tenacity of a tree: finding the light newly blocked on one side, it turns in another. A blind intelligence, true. But out of such persistence arose turtles, rivers, mitochondria, figs — all this resinous, unretractable earth.

Good parasites are invisible; the best are indispensable. Gut bacteria, chloroplasts, mitochondria: all parasites, once.

Mitochondria is the powerhouse of the cell.

The first symptom that your mitochondria are overtaxed is fatigue. Fatigue is an absolute performance killer. It causes cravings, moodiness, brain fog, forgetfulness, and lack of focus.

school you may have learned the basic components of a cell: the nucleus that contains genetic material, the energy-producing mitochondria, the protective membrane at the outside rim, and the cytoplasm in between.

The mitochondria in our cells, that power our metabolism, were formerly free living bacteria, as are the chloroplasts that power those of plants. All complex life-forms are generated through just this kind of cooperative joining, over long evolutionary time, with information built upon information, complexity always increasing in order to more fully stabilize the system. And all such symbiogenic joinings produce life-forms that are not only more complex but whose capacities cannot be predicted from a study of the parts that joined together.

Corporeal reality is much more rich and precious than we realize. It feels good to have a body, to surge on currents of emotion, to have nerve endings, mitochondria in our cells, tangible focused energy, the embodiment of light — given a voice.

The biggest game changer here is eating foods that boost the efficiency of your mitochondria so they can make more energy and your body has the raw goods it needs to manufacture all the proteins, hormones, and fatty acids they require to function.

A careful analysis of the DNA within the mitochondria indicates that errors are indeed concentrated here. The hope is that one day scientists might use the cells' own repair mechanisms to reverse the buildup of errors in the mitochondriaand therefore prolong the cells' useful life.

This was difficult to prove as most hydrogenosomes have lost their entire genome, but it is now established with some certainty.1 In other words, whatever bacteria entered into a symbiotic relationship in the first eukaryotic cell, its descendents numbered among them both mitochondria and hydrogenosomes.

Sperm pass on none of their mitochondria during conception, so all mitochondrial information is transferred from generation to generation through mothers alone. Such a system means that there will be many extinctions along the way. A woman endows all her children with her mitochondria, but only her daughters have the mechanism to pass it onward to future generations. So if a woman has only sons or no children at all—and that happens quite often, of course—her personal mitochondrial line will die with her. All her descendants will still have mitochondria, but it will come from other mothers on other genetic lines. In consequence, the human mitochondrial pool shrinks a little with every generation because of these localized extinctions. Over time, the mitochondrial pool for humans has shrunk so much that, almost unbelievably but rather wonderfully, we are all now descended from a single mitochondrial ancestor—a woman who lived in Africa about 200,000 years ago. You might have heard her referred to as Mitochondrial Eve. She is, in a sense, mother of us all.

As the reader will discover in this book, problems that affect the mitochondria are the basic cause of disease; as Avicenna long ago stated in the 3rd Lesson, 2nd Art, “When the organ function becomes abnormal, then there is a problem with its energy, and a problem with organ’s energy causes a disease in the organ.

Glyphosate also interferes with ATP production by affecting your mitochondrial membranes. When coupled with the so-called inert solvents included in Roundup, the toxicity of glyphosate is magnified as much as 2,000-fold. This makes the membrane more permeable, allowing the glyphosate to go straight to the heart of the mitochondria.

Our terminal decline into old age and death stems from the fine print of the contract that we signed with our mitochondria two billion years ago.

A woman endows all her children with her mitochondria, but only her daughters have the mechanism to pass it onward to future generations.

Inside the “cells” there were no normal-looking organelles, no nuclei, endoplasmic reticulum, mitochondria, or Golgi bodies.

This room is very powerful: Buddha, golden, holding down one side; the primordial Great Mother, black, offering her bead of mitochondria holding down the other.

I sink deeper into his tissues, into the shadows within the cells. I smother mitochondria in the dark.

The ribosomes, for instance, which manufacture proteins, rival in complexity any chemical factory. The mitochondria are power plants which extract energy from food by a complicated chain of chemical reactions involving some fifty different steps: a single cell may have up to five thousand such power plants. Then there are the centrosomes, with their spindle apparatus, which organises the incredible choreography of the cell dividing into two; and the DNA spirals of heredity, coiled up in the inner sanctum of the chromosomes, working their even more potent magic.

Mitochondria manipulate oxygen in a way that liberates energy from foodstuffs. Without this niftily facilitating trick, life on Earth today would be nothing more than a sludge of simple microbes.

Cities are like the mitochondria in our animal cells—they are consumers, fed by the autotrophs, the photosynthesis of a distant green landscape. We could lament that urban dwellers have little means of exercising direct reciprocity with the land. Yet while city folks may be separated from the sources of what they consume, they can exercise reciprocity through how they spend their money. While the digging of the leeks and the digging of the coal may be too far removed to see, we consumers have a potent tool of reciprocity right in our pockets. We can use our dollars as the indirect currency of reciprocity.

Consider the genesis of a single-celled embryo produced by the fertilization of an egg by a sperm. The genetic material of this embryo comes from two sources: paternal genes (from sperm) and maternal genes (from eggs). But the cellular material of the embryo comes exclusively from the egg; the sperm is no more than a glorified delivery vehicle for male DNA—a genome equipped with a hyperactive tail. Aside from proteins, ribosomes, nutrients, and membranes, the egg also supplies the embryo with specialized structures called mitochondria. These mitochondria are the energy-producing factories of the cell; they are so anatomically discrete and so specialized in their function that cell biologists call them “organelles”—i.e., mini-organs resident within cells. Mitochondria, recall, carry a small, independent genome that resides within the mitochondrion itself—not in the cell’s nucleus, where the twenty-three pairs of chromosomes (and the 21,000-odd human genes) can be found. The exclusively female origin of all the mitochondria in an embryo has an important consequence. All humans—male or female—must have inherited their mitochondria from their mothers, who inherited their mitochondria from their mothers, and so forth, in an unbroken line of female ancestry stretching indefinitely into the past. (A woman also carries the mitochondrial genomes of all her future descendants in her cells; ironically, if there is such a thing as a “homunculus,” then it is exclusively female in origin—technically, a “femunculus”?) Now imagine an ancient tribe of two hundred women, each of whom bears one child. If the child happens to be a daughter, the woman dutifully passes her mitochondria to the next generation, and, through her daughter’s daughter, to a third generation. But if she has only a son and no daughter, the woman’s mitochondrial lineage wanders into a genetic blind alley and becomes extinct (since sperm do not pass their mitochondria to the embryo, sons cannot pass their mitochondrial genomes to their children). Over the course of the tribe’s evolution, tens of thousands of such mitochondrial lineages will land on lineal dead ends by chance, and be snuffed out. And here is the crux: if the founding population of a species is small enough, and if enough time has passed, the number of surviving maternal lineages will keep shrinking, and shrinking further, until only a few are left. If half of the two hundred women in our tribe have sons, and only sons, then one hundred mitochondrial lineages will dash against the glass pane of male-only heredity and vanish in the next generation. Another half will dead-end into male children in the second generation, and so forth. By the end of several generations, all the descendants of the tribe, male or female, might track their mitochondrial ancestry to just a few women. For modern humans, that number has reached one: each of us can trace our mitochondrial lineage to a single human female who existed in Africa about two hundred thousand years ago. She is the common mother of our species. We do not know what she looked like, although her closest modern-day relatives are women of the San tribe from Botswana or Namibia. I find the idea of such a founding mother endlessly mesmerizing. In human genetics, she is known by a beautiful name—Mitochondrial Eve.

For example, aging in a car takes place mainly in the engine, where the oxidation and wear and tear take the greatest toll. The “engines” of a cell are the mitochondria. That’s where sugars are oxidized to extract energy.

A few years ago, it was all the rage in biohacker circles to sit in a tub of ice water for cold therapy. That kind of thinking earned me first-degree ice burns over 15 percent of my body (ouch!), but it turns out that it’s not necessary to pack yourself with ice or for the water to be icy—cold water, about 60°F, is a great stimulus for your mitochondria. It sounds miserable, and it is for about thirty seconds. But after that, something shifts, and it feels really good.

Many patients with symptoms of hypothyroidism appear to have normal levels of thyroid hormones. But this is just because most conventional doctors test only for TSH and maybe T4. If you have symptoms of low thyroid, including hair loss, insist on a T3/RT3 test as well. This all means the idea that stress can make your hair fall out is not an old wives’ tale. It can happen when stress causes your body to make more RT3 and less T3 and your mitochondria can’t produce enough energy.

Matters came to a head after 1918, when the French scientist Paul Portier published his rhetorical masterpiece Les Symbiotes. He was nothing if not bold, claiming that: ‘All living beings, all animals from Amoeba to Man, all plants from Cryptogams to Dicotyledons are constituted by an association, the emboîtement of two different beings. Each living cell contains in its protoplasm formations, which histologists designate by the name of mitochondria. These organelles are, for me, nothing other than symbiotic bacteria, which I call symbiotes.

While traditional saunas heat the air around you, infrared light in an infrared sauna directly penetrates and heats your body tissue. You can stay in these saunas longer without feeling like you’re going to pass out. Also, infrared light is beneficial to your mitochondria (see chapter 8 for more on this). Keep in mind that sweating pulls electrolytes and trace minerals from your body, so it’s important to drink a lot of fluids and get plenty of salt (preferably Himalayan pink salt or another mineral-rich natural salt) if you use a sauna to detox.

Were it not for the melanin in our skin, myoglobin in our muscles and haemoglobin in our blood, we would be the colour of mitochondria. And, if this were so, we would change colour when we exercised or ran out of breath, so that you could tell how energized someone was from his or her colour.

Every day in the human body, some 10 billion cells die and are replaced by new cells. The cells that die do not meet a violent unpremeditated end, but are removed silently and unnoticed by apoptosis, all evidence of their demise eaten by neighbouring cells. This means that apoptosis balances cell division

The case I’ve presented in this book suggests that humans are undergoing what biologists call a major transition. Such transitions occur when less complex forms of life combine in some way to give rise to more complex forms. Examples include the transition from independently replicating molecules to replicating packages called chromosomes or, the transition from different kinds of simple cells to more complex cells in which these once-distinct simple cell types came to perform critical functions and become entirely mutually interdependent, such as the nucleus and mitochondria in our own cells. Our species’ dependence on cumulative culture for survival, on living in cooperative groups, on alloparenting and a division of labor and information, and on our communicative repertoires mean that humans have begun to satisfy all the requirements for a major biological transition. Thus, we are literally the beginnings of a new kind of animal.1 By contrast, the wrong way to understand humans is to think that we are just a really smart, though somewhat less hairy, chimpanzee. This view is surprisingly common. Understanding how this major transition is occurring alters how we think about the origins of our species, about the reasons for our immense ecological success, and about the uniqueness of our place in nature. The insights generated alter our understandings of intelligence, faith, innovation, intergroup competition, cooperation, institutions, rituals, and the psychological differences between populations. Recognizing that we are a cultural species means that, even in the short run (when genes don’t have enough time to change), institutions, technologies, and languages are coevolving with psychological biases, cognitive abilities, emotional responses, and preferences. In the longer run, genes are evolving to adapt to these culturally constructed worlds, and this has been, and is now, the primary driver of human genetic evolution. Figure 17.1.

Rather surprisingly, to anyone who is most familiar with textbook mitochondria, many simple single-celled eukaryotes have mitochondria that operate in the absence of oxygen. Instead of using oxygen to burn up food, these ‘anaerobic’ mitochondria use other simple compounds like nitrate or nitrite. In most other respects, they operate in a very similar fashion to our own mitochondria, and are unquestionably related. So the spectrum stretches from aerobic mitochondria like our own, which are dependent on oxygen, through ‘anaerobic’ mitochondria, which prefer to use other molecules like nitrates, to the hydrogenosomes, which work rather differently but are still related.

Cold exposure helps mitochondria, and it also stimulates capillary beds to increase circulation in your skin. Just aim the coldest water that will come out of your shower at your face and neck area for one minute. It will be unbearable for exactly three days, and that’s if you can even do it for a full minute. After that, your mitochondria change their amount of cardiolipin, a component of the inner mitochondrial membrane, so they can produce heat more quickly. The side effect is they can also make energy better, and suddenly that cold shower goes from painful to strangely relaxing and invigorating. Your collagen will thank you if you decide to experience three days of discomfort.

A sedentary lifestyle—too much time spent on couches or at desks and not enough movement—is the most common trigger for muscular atrophy. When we move our muscles as little as possible, with a sedentary lifestyle, we turn down our furnaces and literally cause our muscles to atrophy. When the cells atrophy, we feel even more tired because we have fewer mitochondria generating ATP. A vicious circle begins: less energy leading to less movement, which leads to less energy, which leads to less movement. Atrophy from a sedentary lifestyle leads to weight gain, loss of energy, and chronic aches and pains. But atrophy can be easily prevented, stopped, and even reversed with daily gentle full-body exercise.

To visualize this dance, the transparent components of the cell had to be coloured using a stain. As it happened, the stains that were best able to colour the chromosomes were acidic. Unfortunately, these stains tended to dissolve the mitochondria; their obsession with the nucleus meant that cytologists were simply dissolving the evidence. Other stains were ambivalent, colouring mitochondria only transiently, for the mitochondria themselves rendered the stain colourless. Their rather ghostly appearance and disappearance was scarcely conducive to firm belief. Finally Carl Benda demonstrated, in 1897, that mitochondria do have a corporeal existence in cells. He defined them as ‘granules, rods, or filaments in the cytoplasm of nearly all cells … which are destroyed by acids or fat solvents.’ His term, mitochondria (pronounced ‘my-toe-con-dree-uh’), was derived from the Greek mitos, meaning thread, and chondrin, meaning small grain. Although his name alone stood the test of time, it was then but one among many. Mitochondria have revelled in more than thirty magnificently obscure names, including chondriosomes, chromidia, chondriokonts, eclectosomes, histomeres, microsomes, plastosomes, polioplasma, and vibrioden.

That’s one of the reasons that many people with epilepsy have found success with the so-called ketogenic diet. The ketogenic diet forces the body to take energy from healthy fats. These healthy fats are rich with deuterium-depleted water. That also may be why many find benefits from fasting because it forces our body to burn our fat stores. This causes the release of deuterium-depleted water from within our own fat cells, fueling healthy mitochondria.

We all come into existence as a single cell, smaller than a speck of dust. Much smaller. Divide. Multiply. Add and subtract. Matter changes hands, atoms flow in and out, molecules pivot, proteins stitch together, mitochondria send out their oxidative dictates; we begin as a microscopic electrical swarm. The lungs the brain the heart. Forty weeks later, six trillion cells get crushed in the vise of our mother's birth canal and we howl. Then the world starts in on us.

Buchner proposed that fermentation was carried out by biological catalysts that he named enzymes (from the Greek en zyme, meaning in yeast). He concluded that living cells are chemical factories, in which enzymes manufacture the various products.

They also come in a sumptuously wide range of sizes—nowhere more strikingly than at the moment of conception, when a single beating sperm confronts an egg eighty-five thousand times bigger than it (which rather puts the notion of male conquest into perspective). On average, however, a human cell is about twenty microns wide—that is about two hundredths of a millimeter—which is too small to be seen but roomy enough to hold thousands of complicated structures like mitochondria, and millions

The pounds of molecular information we put into our bodies daily impact our health. Every thought you have and feeling you feel comes from food. Inside your mother’s body, you were 3D printed out of food, and every item you ingest continues to print the next iteration of yourself. Bodies, neurotransmitters, hormones, nerves, and mitochondria are all made, exclusively and necessarily, from what you (or your mom) put in your (or their) mouth; we don’t arise from thin air, we arise from food.

we see that two types of stress (calorie restriction and exercise) cause you to turbocharge your cells with more mitochondria. But as they get older, most people don’t restrict calories, use intermittent fasting, or do much strength training. The result is less muscle mass and fewer mitochondria for most older people—but this is not inevitable. Slightly stressed cells and hungry muscles will lead to more mitochondria, lower insulin levels, more muscle mass, and overall better health for many years to come.

This is the mitochondrial DNA.” Bowers nodded back to the cryo-case. “It’s the genetic material that actually makes the energy that powers our cells. Think of it like this. Each of our cells has the usual 23 pairs of chromosomes that make us human and determine our physical appearance, how we fight off disease, and other physical characteristics. Now think of the mitochondria as little organisms within our cells. Like cells within a cell. It’s those little organisms that make energy for our cells. And they have their own DNA.” “I

You may recall from an earlier chapter that the mitochondria are thought to have originated as captive bacteria and that they now live essentially as lodgers in our cells, preserving their own genetic instructions, dividing to their own timetable, speaking their own language. You may also recall that we are at the mercy of their goodwill. Here’s why. Virtually all the food and oxygen you take into your body are delivered, after processing, to the mitochondria, where they are converted into a molecule called adenosine triphosphate, or ATP.

Human beings tend to think that light-sensitive molecules exist only in the eyes, but they come in four major types: rhodopsin (in the retina, which absorbs light for vision), hemoglobin (in red blood cells), myoglobin (in muscle), and most important of all, cytochrome (in all the cells). Cytochrome is the marvel that explains how lasers can heal so many different conditions, because it converts light energy from the sun into energy for the cells. Most of the photons are absorbed by the energy powerhouses within the cells, the mitochondria.

About 74 percent of U.S. adults are overweight or obese, and 93.2 percent have metabolic dysfunction. These numbers sound high until you realize how many levers of modern society are stacked against our mitochondria and metabolism: too much sugar, too much stress, too much sitting, too much pollution, too many pills, too many pesticides, too many screens, too little sleep, and too little micronutrients. These trends—with trillions of dollars behind them—are causing epidemic levels of mitochondrial dysfunction and underpowered, sick, inflamed bodies.

We couldn’t live for two minutes without them, yet even after a billion years mitochondria behave as if they think things might not work out between us. They maintain their own DNA. They reproduce at a different time from their host cell. They look like bacteria, divide like bacteria, and sometimes respond to antibiotics in the way bacteria do. In short, they keep their bags packed. They don’t even speak the same genetic language as the cell in which they live. It is like having a stranger in your house, but one who has been there for a billion years.

It is all an immensely demanding process. Your heart must pump 75 gallons of blood an hour, 1,800 gallons every day, 657,000 gallons in a year—that’s enough to fill four Olympic-sized swimming pools—to keep all those cells freshly oxygenated. (And that’s at rest. During exercise the rate can increase as much as sixfold.) The oxygen is taken up by the mitochondria. These are the cells’ power stations, and there are about a thousand of them in a typical cell, though the number varies considerably depending on what a cell does and how much energy it requires.

In other words, carbs can be seen as a far dirtier fuel than fats. When you adopt a high-fat, low-carb diet and make the switch to burning fat and ketones for fuel instead of glucose, your mitochondria’s exposure to oxidative damage drops by as much as 30 to 40 percent compared to when your primary source of fuel is sugar, as is typical in American diets today. This means that when you are “fat adapted”—that is, when you have made the transition to burning fat for fuel—your mitochondrial DNA, cell membranes, and protein can remain stronger, healthier, and more resilient. In order

Although it’s hard to believe, gram for gram, we are likely the most powerful energy producers in the universe. In fact, in an interesting calculation outlined by Nick Lane in his book Power, Sex, Suicide, it seems we produce ten thousand times more energy (per gram) than the sun every second.

The sheer mystery and majesty of heritage wisdom, contained in each cell, each mitochondria, instills in the farmer who respects and honors the pigness of the pig a daily emotional high. The satisfaction of being nature's nurturer always trumps the short-lived adrenaline high of being nature's conqueror. Such an attitude offers spiritual ascendance over physical domination, which never really happens anyway. And that's why the industrial farmer, for all the smoke and noise and horsepower, never feels in control, but always dreads being drowned by the nature he thinks he's controlling.

The point I want to make about methanogens is that they were the losers in the race through a bottleneck, yet nonetheless survived in niche environments. Similarly, on a larger scale, it is rare for the loser to disappear completely, or for the latecomers never to gain at least a precarious foothold. The fact that flight had already evolved among birds did not preclude its later evolution in bats, which became the most numerous mammalian species. The evolution of plants did not lead to the disappearance of algae, or indeed the evolution of vascular plants to the disappearance of mosses.

Thermoneutrality”: A hallmark of modern industrial life is spending most of our time indoors at relatively consistent ambient temperatures, a concept we’ll refer to as thermoneutrality. Interestingly, experiencing swings in temperature is great for mitochondrial function, as cold stimulates the body to generate more warmth by increasing mitochondrial activity and stimulates more ATP generation and use. Heat exposure has been shown to activate heat shock proteins (HSPs) within cells, which can protect mitochondria from damage and help to maintain their function. HSPs can also stimulate the production of new mitochondria and improve their efficiency in producing ATP.

Our modern diets and lifestyles are synergistically ravaging our mitochondria. Our mitochondria and the greater cells that house them co-evolved over eons in relationship with our environment. Their mechanisms work in connection with a combination of inputs and information that come from the outside world into our bodies and ultimately into them. Certain kinds of nutrients, sunlight, and information from bacteria in the gut, among other things, all help trigger or supply the cells and their powerhouses with what they require to work. But many of those inputs and information streams have changed radically, resulting in blocks to proper mitochondrial function and downright damage to

Mary cringed every time she read a popular article that tried to explain why mitochondrial DNA is only inherited from the maternal line. The explanation usually given was that only the heads of sperm penetrate eggs, and only the midsections and tails of sperm contain mitochondria. But although it was true that mitochondria were indeed deployed that way in sperm, it wasn’t true that only the head made it into the ovum. Microscopy and DNA analyses both proved that mtDNA from the sperm’s midsection does end up in fertilized mammalian eggs. The truth was no one knew why the paternal mitochondrial DNA isn’t incorporated into the zygote the way maternal mitochondrial DNA is; for some reason it just disappears

Try a cognitive enhancer from the list in this chapter to promote healthy brain function and avoid cognitive degeneration as you age. Here is the short list: •​Piracetam: Reduces cognitive decline with age •​Modafinil: Performance enhancing, not anti-aging •​Nicotine: Low doses (not from cigarettes) can be helpful for aging and cognitive performance •​Deprenyl: Works on dopamine receptors for cognitive enhancement •​CoQ10: Helps your mitochondria produce energy •​PQQ: A powerful antioxidant for anti-aging •​L-theanine: An amino acid that helps with memory and mental endurance •​Curcumin: Improves memory and attention while acting as an antioxidant •​He Shou Wu: Longevity-enhancing antioxidant herb that can also help you regrow and regain color in your hair!

you’re over fifty or have dealt with serious health problems in the past, find a local ozone doctor and get IV treatments when they are affordable for you. At worst, your mitochondria will become better. At best, the ozone will knock out other unpleasant stuff growing in your body that you don’t even know about. •​If you have arthritis or sore joints that don’t get better, consider prolozone injections into the impacted joint to speed healing dramatically. •​If you’re having dental work done, look for a dentist who uses ozone gas to sterilize the teeth before treatments. This can help you avoid chronic inflammation and its corresponding aging. •​Up your NAD+ with supplements or IV treatments to boost mitochondrial function at any age. If you don’t want to try either of these, you can increase your NAD+ levels through cyclical ketosis, intermittent fasting, and/or calorie restriction.

Women are anatomically different in one other very significant way: they are the sacred keepers of human mitochondria—the vital little powerhouses of our cells. Sperm pass on none of their mitochondria during conception, so all mitochondrial information is transferred from generation to generation through mothers alone. Such a system means that there will be many extinctions along the way. A woman endows all her children with her mitochondria, but only her daughters have the mechanism to pass it onward to future generations. So if a woman has only sons or no children at all—and that happens quite often, of course—her personal mitochondrial line will die with her. All her descendants will still have mitochondria, but it will come from other mothers on other genetic lines. In consequence, the human mitochondrial pool shrinks a little with every generation because of these localized extinctions.

The people in whom CFS often takes a hold are those driven, workaholic, goal driven, perfectionist, 'never say die' characters. This is because these people ignore the normal cues that make us stop striving - they continue despite symptoms of fatigue and pain in order to achieve. The achievement is at the expense of their health. Furthermore, these personalities are more likely to turn to addictions to mask symptoms in order that they can keep going.

The second is that our food is being transported over large distances, causing degradation and damage to nutrients. The average distance that produce travels from farm to plate in the United States is approximately fifteen hundred miles. During this journey, some fruits and vegetables can lose up to 77 percent of their vitamin C content, a critical micronutrient for ATP production in the mitochondria and antioxidant activity in the cell. You may have thought that “eating local” or shopping from farmers’ markets is frivolous, but it is actually a critical step to ensure you are getting maximal helpful molecular information in the bites you take to build and instruct your body. The third is that most of our U.S. calorie consumption is ultra-processed foods, stripped of their nutrition. About 60 percent or more of the calories adults in the nation consume is ultra-processed garbage. You’re looking at just a fraction of that seventy tons meeting the cells’ functional needs. No

For years, exercise scientists have been convinced that the only way to increase mitochondrial density is with aerobic endurance training, but recent studies have proved otherwise. Not only is an increase in the size and number of mitochondria a proven adaptation to HIIT, but the mitochondrial benefit of HIIT goes way beyond size and number. For example, all your mitochondria contain oxidative enzymes, such as citrate synthase, malate dehydrogenase, and succinate dehydrogenase. These oxidative enzymes lead to improved metabolic function of your skeletal muscles—particularly by causing more effective fat and carbohydrate breakdown for fuel and also by accelerating energy formation from ATP. So more oxidative enzymes means that you have a higher capacity for going longer and harder. And it turns out that, according to an initial study on the effect of HIIT on oxidative enzymes, there were enormous increases in skeletal muscle oxidative enzymes in seven weeks in subjects who did four to ten thirty-second maximal cycling sprints followed by four minutes of recovery just three days a week. But what about HIIT as opposed to aerobic cardio? Another six-week training study compared the increase in oxidative enzymes that resulted from either: 1. Four to six thirty-second maximal-effort cycling sprints, each followed by four-and-a-half minutes of recovery, performed three days a week (classic HIIT training) or 2. Forty to sixty minutes of steady cycling at 65 percent VO2 max (an easy aerobic intensity) five days a week The levels of oxidative enzymes in the mitochondria in subjects who performed the HIIT program were significantly higher—even though they were training at a fraction of the volume of the aerobic group. How could this favorable endurance adaptation happen with such short periods of exercise? It turns out that the increased mitochondrial density and oxidative-enzyme activity from HIIT are caused by completely different message-signaling pathways than those created by traditional endurance training.

Energy and life go hand in hand. If you stop breathing, you will not be able to generate the energy you need for staying alive and you’ll be dead in a few minutes. Keep breathing. Now the oxygen in your breath is being transported to virtually every one of the 15 trillion cells in your body, where it is used to burn glucose in cellular respiration. You are a fantastically energetic machine. Gram per gram, even when sitting comfortably, you are converting 10 000 times more energy than the sun every second.

A note of caution: epigenetics is also on the verge of transforming into a dangerous idea. Epigenetic modifications of genes can potentially superpose historical and environmental information on cells and genomes—but this capacity is speculative, limited, idiosyncratic, and unpredictable: a parent with an experience of starvation produces children with obesity and overnourishment, while a father with the experience of tuberculosis, say, does not produce a child with an altered response to tuberculosis. Most epigenetic “memories” are the consequence of ancient evolutionary pathways, and cannot be confused with our longing to affix desirable legacies on our children. As with genetics in the early twentieth century, epigenetics is now being used to justify junk science and enforce stifling definitions of normalcy. Diets, exposures, memories, and therapies that purport to alter heredity are eerily reminiscent of Lysenko’s attempt to “reeducate” wheat using shock therapy. Mothers are being asked to minimize anxiety during their pregnancy—lest they taint all their children, and their children, with traumatized mitochondria. Lamarck is being rehabilitated into the new Mendel. These glib notions about epigenetics should invite skepticism. Environmental information can certainly be etched on the genome. But most of these imprints are recorded as “genetic memories” in the cells and genomes of individual organisms—not carried forward across generations. A man who loses a leg in an accident bears the imprint of that accident in his cells, wounds, and scars—but does not bear children with shortened legs. Nor has the uprooted life of my family seem to have burdened me, or my children, with any wrenching sense of estrangement. Despite Menelaus’s admonitions, the blood of our fathers is lost in us—and so, fortunately, are their foibles and sins. It is an arrangement that we should celebrate more than rue. Genomes and epigenomes exist to record and transmit likeness, legacy, memory, and history across cells and generations. Mutations, the reassortment of genes, and the erasure of memories counterbalance these forces, enabling unlikeness, variation, monstrosity, genius, and reinvention—and the refulgent possibility of new beginnings, generation upon generation.

Welcome back, Dr. Shapiro. I’ve told Dr. Grace about our sexual relationship.” I put my head in my hands. “Cool,” said Annie. “Yeah, we’ve got nothing to hide.” “In any event,” said DuBois, “if I remember the previous lesson correctly, we were working on the cellular biology within Astrophage mitochondria.” I cleared my throat. “Yes. Today I’ll be talking about the Astrophage’s Krebs cycle. It’s identical to what we find in Earth mitochondria, but with one additional step—” Annie held up her hand. “Oh, sorry. One more thing—” She turned to DuBois. “Martin, we have about fifteen minutes of personal time after this lesson and before our next training exercise. Want to meet up in the bathroom down the hall and have sex?” “I find that agreeable,” said DuBois. “Thank you, Dr. Shapiro.” “Okay, cool.” They both looked to me, ready for their lesson. I waited a few seconds to make sure there was no more oversharing, but they seemed content. “Okay, so the Krebs cycle in Astrophage has a variant—wait. Do you call her Dr. Shapiro while having sex?” “Of course. That’s her name.” “I kind of like it,” she said. “I’m sorry I asked,” I said. “Now, the Krebs cycle…

Here’s how to do it: First, sit down, get comfortable, and close your eyes. Make sure you’re in a position where you can freely expand your lungs. Wim suggests doing this practice right after waking up since your stomach is still empty. Warm up by inhaling deeply and drawing the breath in until you feel a slight pressure. Hold the breath for a moment before exhaling completely, pushing the air out as much as you can. Hold the exhalation for as long as you can, and then repeat this fifteen times. Next, inhale through your nose and exhale through your mouth in short, powerful bursts, as if you’re blowing up a balloon. Pull in your belly when you’re exhaling and let it expand when you inhale. Do this about thirty times, using a steady pace, until you feel that your body is saturated with oxygen. You may feel light-headed or tingly, or you may experience a surge of energy that’s literally electric. Try to get a sense of which parts of your body are overflowing with energy and which ones are lacking it—and where there are blockages between these two extremes. As you continue breathing, send the breath to those blockages. When you’re done, take one more big breath in, filling your lungs to maximum capacity, and then push all of the air out. Hold this for as long as you can and try to feel the oxygen spreading around your body. When you can’t hold it anymore, inhale fully and feel your chest expanding. Hold it again, sending energy where your body needs it. Bonus points if you do what Wim had me do when we demonstrated this technique onstage at our Bulletproof conference—as you are holding your lungs empty, count how many push-ups you can do before you have to breathe again. I got to twenty! It seems impossible, but you can do it, and that short bit of low oxygen forces your body to better deal with lower-oxygen environments. I recommend you research Wim’s work and watch one of his many videos online demonstrating his breathing technique. I don’t think it works as well as mechanically filtering oxygen out of the air you breathe, but the Wim Hof technique is absolutely free, totally portable, and Wim is capable of things I could never do! His breathing method helps your body adapt to bursts of oxygen and puts you more in tune with the way your body uses your breath to create energy. It also makes you more resilient to cold temperatures, but there is evidence that cold temperatures themselves are good for your mitochondria.

Pigments such as haemoglobin are coloured because they absorb light of particular colours (bands of light, as in a rainbow) and reflect back light of other colours. The pattern of light absorbed by a compound is known as its absorption spectrum. When binding oxygen, haemoglobin absorbs light in the blue-green and yellow parts of the spectrum, but reflects back red light, and this is the reason why we perceive arterial blood as a vivid red colour. The absorption spectrum changes when oxygen dissociates from haemoglobin in venous blood. Deoxyhaemoglobin absorbs light across the green part of the spectrum, and reflects back red and blue light. This gives venous blood its purple colour.

We are each of us the result of billions of years of the universe evolving toward its own splendor. And evolution builds: the very mitochondria that power our cells and give us life once existed as separate organisms that first infected our pre–pre–human ancestors and then became one with them. We each contain not only the slime mold and the worm, the fish and amphibian and reptile, but the pig and the ape and the barely human. If we look hard enough, we can discern hundreds of parts: kings and queens, warriors and troubadours, mages, bullies, and saints. And hustlers, adventurers, survivors, rebels, reactionaries, and rogues. And the part of us that wants to be more than human, or rather more fully human. I believe that we need to enlist all these separate selves into a single army of free companions who respect each other and love each other to the death. And who are willing to devote their lives to fight together in order to win a shared splendor. I will return to this theme of integration again and again, for it is key to everything. All of my characters struggle with themselves, and face as well external obstacles such as exploding stars or dragons or icy wastelands cold enough to freeze the breath. Maram, who writes poems glorifying his second chakra (the body’s sexual center), pants like a dog after every enticing woman he sees. Even as he resists his essential nobility and destiny as a hero, he insists that every man deserves at least one vice. When it is pointed out to him that he also drinks, gambles, gluttonizes, and whores, he declares that he is still trying to decide which vice will be his.

Suppose you entered a boat race. One hundred rowers, each in a separate rowboat, set out on a ten-mile race along a wide and slow-moving river. The first to cross the finish line will win $10,000. Halfway into the race, you’re in the lead. But then, from out of nowhere, you’re passed by a boat with two rowers, each pulling just one oar. No fair! Two rowers joined together into one boat! And then, stranger still, you watch as that rowboat is overtaken by a train of three such rowboats, all tied together to form a single long boat. The rowers are identical septuplets. Six of them row in perfect synchrony while the seventh is the coxswain, steering the boat and calling out the beat for the rowers. But those cheaters are deprived of victory just before they cross the finish line, for they in turn are passed by an enterprising group of twenty-four sisters who rented a motorboat. It turns out that there are no rules in this race about what kinds of vehicles are allowed. That was a metaphorical history of life on Earth. For the first billion years or so of life, the only organisms were prokaryotic cells (such as bacteria). Each was a solo operation, competing with others and reproducing copies of itself. But then, around 2 billion years ago, two bacteria somehow joined together inside a single membrane, which explains why mitochondria have their own DNA, unrelated to the DNA in the nucleus.35 These are the two-person rowboats in my example. Cells that had internal organelles could reap the benefits of cooperation and the division of labor (see Adam Smith). There was no longer any competition between these organelles, for they could reproduce only when the entire cell reproduced, so it was “one for all, all for one.” Life on Earth underwent what biologists call a “major transition.”36 Natural selection went on as it always had, but now there was a radically new kind of creature to be selected. There was a new kind of vehicle by which selfish genes could replicate themselves. Single-celled eukaryotes were wildly successful and spread throughout the oceans.

How did the results for the two groups compare? Basically, the improvements were the same for every fitness parameter that we measured. That means both groups improved following the training, but we could not detect any significant differences in the extent of the change between the two groups. The increase in aerobic fitness? The same. The increase in mitochondria in the subjects’ muscles? The same. The change in fuel use and, particularly, the subjects’ ability to burn fat during exercise? The same.

Within every cell in your body is a posse of organelles (or miniature organs) called mitochondria

Now, here’s the key thing you need to know about mitochondria: Like any other sort of engine, they generate energy, but they also generate waste. However, unlike your car engine, which turns gasoline into energy while creating smog, the mitochondria turn food into energy while creating something called free radicals.

Tripping Over the Truth, by Travis Christofferson.

Nick Lane in his book Power, Sex, Suicide,

Today it is widely recognized that the cells of animals were once a wild party of two if not three ancient beings: the oxygen-poisoned archaeon host, the oxygen-using bacteria that became mitochondria, and perhaps wildly squirming spirochetes, which abound in anaerobic environments.

Another strange fact is that one form of these alien entities has been with us since we were little more than microbes ourselves. Mitochondria are physically independent structures that contain their own DNA designated as mtDNA, which is inherited by humans down the female line. Analysis of mtDNA in the brain tissue of females has allowed very accurate mapping of evolutionary relationships, leading to the conclusion that modern humans evolved in Africa.

In the normal process of producing energy, each mitochondrion produces hundreds if not thousands of free radical molecules each day. Multiply that by the ten million billion mitochondria that we each possess and you come up with an unfathomable number, ten

ketogenic diet has also been shown to reduce amyloid in the brain,25 and it increases glutathione, the body’s natural brain-protective antioxidant, in the hippocampus.26 What’s more, it stimulates the growth of mitochondria and thus increases metabolic efficiency.27

We owe our liberation to chemistry," he went on. "For all perception is but a change in the concentration of hydrogen ions on the surface of the brain cells. Seeing me, you actually experience a disturbance in the sodium-potassium equilibrium across your neuron membranes. So all we have to do is send a few well-chosen molecules down into those cortical mitochondria, activate the right neurohumoral-synaptic transmission effector sites, and your fondest dreams come true. But you know all this," he concluded, subdued.

Yes. There are a variety of reasons that we as humans age, one of which is oxidant stress from free radical formation. Known as the Free Radical Theory of Aging, this explanation was first proposed by Denham Harman in the 1950s. Other theories include unchecked inflammation, glycation, cell membrane and DNA damage. Interestingly, they are interrelated as I will explain. Every cell in our body requires energy for a variety of processes. The production of such cellular energy or ATP (adenosine triphosphate) is occurring at the molecular level, unbeknownst to you, billions of times per second, in cellular structures known as mitochondria. Through a complex series of chemical reactions, electrons are ultimately transferred to oxygen, driving the formation of ATP molecules. No oxygen, no electron receptor, death ensues. (Note: Cyanide poisons this so-called “electron transport chain” often times resulting in death.) This process of ATP generation is imperfect.

At Ardennes she conceived a desire to strangle the young woman who prepped and held down garde manger. The woman, Becky Hemerling, was a culinary-institute grad with wavy blond hair and a petite flat body and fair skin that turned scarlet in the kitchen heat. Everything about Becky Hemerling sickened Denise—her C.I.A. education (Denise was an autodidact snob), her overfamiliarity with more senior cooks (especially with Denise), her vocal adoration of Jodie Foster, the stupid fish-and-bicycle texts on her T-shirts, her overuse of the word “fucking” as an intensifier, her self-conscious lesbian “solidarity” with the “latinos” and “Asians” in the kitchen, her generalizations about “right-wingers” and “Kansas” and “Peoria,” her facility with phrases like “men and women of color,” the whole bright aura of entitlement that came of basking in the approval of educators who wished that they could be as marginalized and victimized and free of guilt as she was. What is this person doing in my kitchen? Denise wondered. Cooks were not supposed to be political. Cooks were the mitochondria of humanity; they had their own separate DNA, they floated in a cell and powered it but were not really of it. Denise suspected that Becky Hemerling had chosen the cooking life to make a political point: to be one tough chick, to hold her own with the guys. Denise loathed this motivation all the more for harboring a speck of it herself. Hemerling had a way of looking at her that suggested that she (Hemerling) knew her better than she knew herself—an insinuation at once infuriating and impossible to refute. Lying awake beside Emile at night, Denise imagined squeezing Hemerling’s neck until her blue, blue eyes bugged out. She imagined pressing her thumbs into Hemerling’s windpipe until it cracked.    Then one night she fell asleep and dreamed that she was strangling Becky and that Becky didn’t mind. Becky’s blue eyes, in fact, invited further liberties. The strangler’s hands relaxed and traveled up along Becky’s jawline and past her ears to the soft skin of her temples. Becky’s lips parted and her eyes fell shut, as if in bliss, as the strangler stretched her legs out on her legs and her arms out on her arms…    Denise couldn’t remember being sorrier to wake from a dream.    “If you can have this feeling in a dream,” she said to herself, “it must be possible to have it in reality.

In summary, the origin of carcinogenesis resides with the mitochondria in the cytoplasm, not with the genome in the nucleus.

It was Owen who defined 'homologous organs' as 'the same organ in different animals under every variety of form and function'. While he tirelessly demonstrated the multitude of such organs in the animal kingdom, he attributed them to the parsimony of the divine Designer-just as Kepler had attributed his planetary laws to the ingenuity of the divine Mathematician. But whatever the beliefs of these men, the concept of homology came to stay, and became a cornerstone of modern evolutionary theory. Animals and plants are made out of homologous organelles like the mitochondria, homologous organs like gills and lungs, homologous limbs such as arms and wings. They are the stable holons in the evolutionary flux. The phenomena of homology implied in fact the hierarchic principle in phylogeny as well as in ontogeny. But the point was never made explicit, and the principles of hierarchic order hardly received a cursory glance. This may be why the inherent contradictions of the orthodox theory could pass so long unnoticed.

Here is the standard replacement schedule: Cell Type Turnover Time Small and Large Intestine 4 days Skin 2-3 weeks Mitochondria 3 weeks Red Blood Cells 4 months Stomach 7 days Pancreas 40 days Bone 3 years Fat Cells 8 years Heart Muscle 50 years Lens Never Neurons Never Tattoos Never

Recommended Dose: Supplement with 750 to 1500 mg of pomegranate extract or eat ½ to 1 pomegranate daily

Recommended Dose: Eat 1 to 2 cups of blueberries per day.

There are numerous neurotransmitters in the body, but the five most important for energy levels include: Acetylcholine Dopamine Serotonin Orexin

There are numerous neurotransmitters in the body, but the five most important for energy levels include: Acetylcholine Dopamine Serotonin Orexin GABA

Recommended Dose: 600 mg per day of a KSM-66 extract or 150 to 240 mg per day of a Shoden extract, 30 to 60 minutes before bed

Still, if you’re interested in trying CBD and it’s within reach financially, then we recommend experimenting with doses of 25 to 100 mg taken 30 to 60 minutes before bed. Recommended Dose: 25 to 100 mg per day, 30 to 60 minutes before bed