Medical Advancement Quotes

I look at the blanked-out faces of the other passengers--hoisting their briefcases, their backpacks, shuffling to disembark--and I think of what Hobie said: beauty alters the grain of reality. And I keep thinking too of the more conventional wisdom: namely, that the pursuit of pure beauty is a trap, a fast track to bitterness and sorrow, that beauty has to be wedded to something more meaningful. Only what is that thing? Why am I made the way I am? Why do I care about all the wrong things, and nothing at all for the right ones? Or, to tip it another way: how can I see so clearly that everything I love or care about is illusion, and yet--for me, anyway--all that's worth living for lies in that charm? A great sorrow, and one that I am only beginning to understand: we don't get to choose our own hearts. We can't make ourselves want what's good for us or what's good for other people. We don't get to choose the people we are. Because--isn't it drilled into us constantly, from childhood on, an unquestioned platitude in the culture--? From William Blake to Lady Gaga, from Rousseau to Rumi to Tosca to Mister Rogers, it's a curiously uniform message, accepted from high to low: when in doubt, what to do? How do we know what's right for us? Every shrink, every career counselor, every Disney princess knows the answer: "Be yourself." "Follow your heart." Only here's what I really, really want someone to explain to me. What if one happens to be possessed of a heart that can't be trusted--? What if the heart, for its own unfathomable reasons, leads one willfully and in a cloud of unspeakable radiance away from health, domesticity, civic responsibility and strong social connections and all the blandly-held common virtues and instead straight toward a beautiful flare of ruin, self-immolation, disaster?...If your deepest self is singing and coaxing you straight toward the bonfire, is it better to turn away? Stop your ears with wax? Ignore all the perverse glory your heart is screaming at you? Set yourself on the course that will lead you dutifully towards the norm, reasonable hours and regular medical check-ups, stable relationships and steady career advancement the New York Times and brunch on Sunday, all with the promise of being somehow a better person? Or...is it better to throw yourself head first and laughing into the holy rage calling your name?

It was my Uncle George who discovered alcohol was a food well in advance of modern medical thought.

Reading list (1972 edition)[edit] 1. Homer – Iliad, Odyssey 2. The Old Testament 3. Aeschylus – Tragedies 4. Sophocles – Tragedies 5. Herodotus – Histories 6. Euripides – Tragedies 7. Thucydides – History of the Peloponnesian War 8. Hippocrates – Medical Writings 9. Aristophanes – Comedies 10. Plato – Dialogues 11. Aristotle – Works 12. Epicurus – Letter to Herodotus; Letter to Menoecus 13. Euclid – Elements 14. Archimedes – Works 15. Apollonius of Perga – Conic Sections 16. Cicero – Works 17. Lucretius – On the Nature of Things 18. Virgil – Works 19. Horace – Works 20. Livy – History of Rome 21. Ovid – Works 22. Plutarch – Parallel Lives; Moralia 23. Tacitus – Histories; Annals; Agricola Germania 24. Nicomachus of Gerasa – Introduction to Arithmetic 25. Epictetus – Discourses; Encheiridion 26. Ptolemy – Almagest 27. Lucian – Works 28. Marcus Aurelius – Meditations 29. Galen – On the Natural Faculties 30. The New Testament 31. Plotinus – The Enneads 32. St. Augustine – On the Teacher; Confessions; City of God; On Christian Doctrine 33. The Song of Roland 34. The Nibelungenlied 35. The Saga of Burnt Njál 36. St. Thomas Aquinas – Summa Theologica 37. Dante Alighieri – The Divine Comedy;The New Life; On Monarchy 38. Geoffrey Chaucer – Troilus and Criseyde; The Canterbury Tales 39. Leonardo da Vinci – Notebooks 40. Niccolò Machiavelli – The Prince; Discourses on the First Ten Books of Livy 41. Desiderius Erasmus – The Praise of Folly 42. Nicolaus Copernicus – On the Revolutions of the Heavenly Spheres 43. Thomas More – Utopia 44. Martin Luther – Table Talk; Three Treatises 45. François Rabelais – Gargantua and Pantagruel 46. John Calvin – Institutes of the Christian Religion 47. Michel de Montaigne – Essays 48. William Gilbert – On the Loadstone and Magnetic Bodies 49. Miguel de Cervantes – Don Quixote 50. Edmund Spenser – Prothalamion; The Faerie Queene 51. Francis Bacon – Essays; Advancement of Learning; Novum Organum, New Atlantis 52. William Shakespeare – Poetry and Plays 53. Galileo Galilei – Starry Messenger; Dialogues Concerning Two New Sciences 54. Johannes Kepler – Epitome of Copernican Astronomy; Concerning the Harmonies of the World 55. William Harvey – On the Motion of the Heart and Blood in Animals; On the Circulation of the Blood; On the Generation of Animals 56. Thomas Hobbes – Leviathan 57. René Descartes – Rules for the Direction of the Mind; Discourse on the Method; Geometry; Meditations on First Philosophy 58. John Milton – Works 59. Molière – Comedies 60. Blaise Pascal – The Provincial Letters; Pensees; Scientific Treatises 61. Christiaan Huygens – Treatise on Light 62. Benedict de Spinoza – Ethics 63. John Locke – Letter Concerning Toleration; Of Civil Government; Essay Concerning Human Understanding;Thoughts Concerning Education 64. Jean Baptiste Racine – Tragedies 65. Isaac Newton – Mathematical Principles of Natural Philosophy; Optics 66. Gottfried Wilhelm Leibniz – Discourse on Metaphysics; New Essays Concerning Human Understanding;Monadology 67. Daniel Defoe – Robinson Crusoe 68. Jonathan Swift – A Tale of a Tub; Journal to Stella; Gulliver's Travels; A Modest Proposal 69. William Congreve – The Way of the World 70. George Berkeley – Principles of Human Knowledge 71. Alexander Pope – Essay on Criticism; Rape of the Lock; Essay on Man 72. Charles de Secondat, baron de Montesquieu – Persian Letters; Spirit of Laws 73. Voltaire – Letters on the English; Candide; Philosophical Dictionary 74. Henry Fielding – Joseph Andrews; Tom Jones 75. Samuel Johnson – The Vanity of Human Wishes; Dictionary; Rasselas; The Lives of the Poets

Henrietta’s were different: they reproduced an entire generation every twenty-four hours, and they never stopped. They became the first immortal human cells ever grown in a laboratory.

Because--isn't it drilled into us constantly, from childhood on, an unquestioned platitude in the culture--? From William Blake to Lady Gaga, from Rousseau to Rumi to Tosca to Mister Rogers, it's a curiously uniform message, accepted from high to low: when in doubt, what to do? How do we know what's right for us? Every shrink, every career counselor, every Disney princess knows the answer: "Be yourself." "Follow your heart." Only here's what I really, really want someone to explain to me. What if one happens to be possessed of a heart that can't be trusted--? What if the heart, for its own unfathomable reasons, leads one willfully and in a cloud of unspeakable radiance away from health, domesticity, civic responsibility and strong social connections and all the blandly-held common virtues and instead straight toward a beautiful flare of ruin, self-immolation, disaster?...If your deepest self is singing and coaxing you straight toward the bonfire, is it better to turn away? Stop your ears with wax? Ignore all the perverse glory your heart is screaming at you? Set yourself on the course that will lead you dutifully towards the norm, reasonable hours and regular medical check-ups, stable relationships and steady career advancement the New York Times and brunch on Sunday, all with the promise of being somehow a better person? Or...is it better to throw yourself head first and laughing into the holy rage calling your name?

The appearance in nineteenth-century psychiatry, jurisprudence, and literature of a whole series of discourses on the species and subspecies of homosexuality, inversion, pederasty, and "psychic hermaphroditism" made possible a strong advance of social controls into this area of "perversity"; but it also made possible the formation of a "reverse" discourse: homosexuality began to speak in its own behalf, to demand that its legitimacy or "naturality" be acknowledged, often in the same vocabulary, using the same categories by which it was medically disqualified.

I’ve tried to imagine how she’d feel knowing that her cells went up in the first space missions to see what would happen to human cells in zero gravity, or that they helped with some of the most important advances in medicine: the polio vaccine, chemotherapy, cloning, gene mapping, in vitro fertilization. I’m pretty sure that she—like most of us—would be shocked to hear that there are trillions more of her cells growing in laboratories now than there ever were in her body.

It behooves me to remember as I advance in age that death is an inevitable part of the life cycle rather than a medical failure.

I am merely at the midway point in the novel of my own life. On around page 250 of a 500-page tale and, given future medical advances, maybe even 200. There’s no reason why the next 250, 300, or even 350 pages will not be far more exciting than the first half.

A sad fact, of course, about adult life is that you see the very things you'll never adapt to coming toward you on the horizon. You see them as the problems they are, you worry like hell about them, you make provisions, take precautions, fashion adjustments; you tell yourself you'll have to change your way of doing things. Only you don't. You can't. Somehow it's already too late. And maybe it's even worse than that: maybe the thing you see coming from far away is not the real thing, the thing that scares you, but its aftermath. And what you've feared will happen has already taken place. This is similar in spirit to the realization that all the great new advances of medical science will have no benefit for us at all, thought we cheer them on, hope a vaccine might be ready in time, think things could still get better. Only it's too late there too. And in that very way our life gets over before we know it. We miss it. And like the poet said: The ways we miss our lives are life.

With me, it was my liver that was out of order. […] I had the symptoms, beyond all mistake, the chief among them being "a general disinclination to work of any kind." What I suffer in that way no tongue can tell. From my earliest infancy I have been a martyr to it. As a boy, the disease hardly ever left me for a day. They did not know, then, that it was my liver. Medical science was in a far less advanced state than now, and they used to put it down to laziness.

Love is a chemical reaction, But it cannot be fully understood or defined by science. And though a body cannot exist without a soul, It too cannot be fully understood or defined by science. Love is the most powerful form of energy, But science cannot decipher its elements. Yet the best cure for a sick soul is love, But even the most advanced physician Cannot prescribe it as medicine. INCOMPLETE SCIENCE by Suzy Kassem

In all, 86 per cent of the increased life expectancy was due to decreases in infectious diseases. And the bulk of the decline in infectious disease deaths occurred prior to the age of antibiotics. Less than 4 per cent of the total improvement in life expectancy since 1700s can be credited to twentieth-century advances in medical care.

After all this time, with all the medical advances we’ve made, the human body is still an unfathomable mystery to us. The heart most of all.

After all, all devices have their dangers. The discovery of speech introduced communication—and lies. The discovery of fire introduced cooking—and arson. The discovery of the compass improved navigation—and destroyed civilizations in Mexico and Peru. The automobile is marvelously useful—and kills Americans by the tens of thousands each year. Medical advances have saved lives by the millions—and intensified the population explosion.

Is Kitsey right? If your deepest self is singing and coaxing you straight toward the bonfire, is it better to turn away? Stop your ears with wax? Ignore all the perverse glory your heart is screaming at you? Set yourself on the course that will lead you dutifully towards the norm, reasonable hours and regular medical check-ups, stable relationships and steady career advancement, the New York Times and brunch on Sunday, all with the promise of being somehow a better person? Or—like Boris—is it better to throw yourself head first and laughing into the holy rage calling your name?

Love is a chemical reaction, but it cannot be fully understood or defined by science. And though a body cannot exist without a soul, it too cannot be fully understood or defined by science. Love is the most powerful form of energy, but science cannot decipher its elements. Yet the best cure for a sick soul is love, but even the most advanced physician cannot prescribe it as medicine.

Nathan stared at the floor. “Honestly? He’s a C5-6 quadriplegic. That means nothing works below about here…” He placed a hand on the upper part of his chest. “They haven’t worked out how to fix a spinal cord yet.” I stared at the door, thinking about Will’s face as we drove along in the winter sunshine, the beaming face of the man on the skiing holiday. “There are all sorts of medical advances taking place, though, right? I mean…somewhere like this…they must be working on stuff all the time.

Out of all the medical advancements in human history I'm still most in awe of that tiny little piece of toilet paper that can stop a gushing razor cut in its tracks.

A blanket could be used in exciting medical advancements, curing everything from shivers to tonitrophobia.


Contemporary medical technology is not an advancement in medicine- it indicates the failure of Caucasian medical science and is a sign of ignorance. Technology cannot replace the human ability to diagnose disease by looking, touching and smelling to perform treatments without drugs.

While the Lord has blessed us with medical advancements to combat death, their efficacy depends on his mercy. He does not need our help, nor does he call us to pursue futile interventions to give him time.

Today, though, doctors and nurses have replaced family and friends, an unintended consequence of the advancement of medical science. We fear death because we don’t know it, we don’t see it, and we don’t touch it. And what we don’t know, we’ve painted in broad strokes of darkness and negativity. The death negative narrative wouldn’t be so strong if we only had the ability to see, touch, and hold our dying and our dead.

What if the heart, for its own unfathomable reasons, leads one willfully and in a cloud of unspeakable radiance away from health, domesticity, civic responsibility and strong social connections and all the blandly-held common virtues and instead straight toward a beautiful flare of ruin, self-immolation, disaster?…If your deepest self is singing and coaxing you straight toward the bonfire, is it better to turn away? Stop your ears with wax? Ignore all the perverse glory your heart is screaming at you? Set yourself on the course that will lead you dutifully towards the norm, reasonable hours and regular medical check-ups, stable relationships and steady career advancement the New York Times and brunch on Sunday, all with the promise of being somehow a better person? Or…is it better to throw yourself head first and laughing into the holy rage calling your name?

Enslavement could not have existed and certainly could not have persisted without medical science. However, physicians were also dependent upon slavery, both for economic security and for the enslaved “clinical material” that fed the American medical research and medical training that bolstered physicians’ professional advancement.

According to Hugh Thomas, author of 'A History of the World', the greatest medical advance in history has been garbage collection. The greatest psychological advance in history is just around the corner and will also have to do with cleaning up. Cleaning up lies and "coming out of the closet" is getting more attention these days. Some day we will look back on these years of suffocation in bullsh*t in the same way we look back on all the years people lived in, and died from, their garbage.

demedicalization of pregnancy isn’t necessarily a good thing—we should be proud of medical advances that objectively save lives, not scared of them. I

Medical science was in a far less advanced state than now, and they used to put it down to laziness.

Claiming that the past was socially better than the present is also a hallmark of white supremacy. Consider any period in the past from the perspective of people of color: 246 years of brutal enslavement; the rape of black women for the pleasure of white men and to produce more enslaved workers; the selling off of black children; the attempted genocide of Indigenous people, Indian removal acts, and reservations; indentured servitude, lynching, and mob violence; sharecropping; Chinese exclusion laws; Japanese American internment; Jim Crow laws of mandatory segregation; black codes; bans on black jury service; bans on voting; imprisoning people for unpaid work; medical sterilization and experimentation; employment discrimination; educational discrimination; inferior schools; biased laws and policing practices; redlining and subprime mortgages; mass incarceration; racist media representations; cultural erasures, attacks, and mockery; and untold and perverted historical accounts, and you can see how a romanticized past is strictly a white construct. But it is a powerful construct because it calls out to a deeply internalized sense of superiority and entitlement and the sense that any advancement for people of color is an encroachment on this entitlement.

considering all the comforts and medical advancements of modern life, we could easily argue that we currently exist in a state of devolution. For the most part, this is great (many of us have suffered illnesses or traumas over the course of our lives that would have killed us a century ago, let alone 1,000 or 10,000 years ago). However, we must be vigilant not to let the advantages of modern life compromise our health

At that point, more than 15,000 women were dying each year from cervical cancer. The Pap smear had the potential to decrease that death rate by 70 percent or more, but there were two things standing in its way: first, many women - like Henrietta - simply didn't get the test; and, second, even when they did, few doctors knew how to interpret the results accurately, because they didn't know what various stages of cervical cancer looked like under a microscope. Some mistook cervical infections for cancer and removed a woman's entire reproductive tract when all she needed was antibiotics. Others mistook malignant changes for infection, sending women home with antibiotics only to have them return later, dying from metastasized cancer. And even when doctors correctly diagnosed precancerous changes, they often didn't know how those changes should be treated.

Doctor Benway is operating in an auditorium filled with students: "Now, boys, you won't see this operation performed very often and there's a reason for that ... You see it has absolutely no medical value. No one knows what the purpose of it originally was or if it had a purpose at all. Personally I think it was a pure artistic creation from the beginning. Just as a bull fighter with his skill and knowledge extricates himself from danger he has himself invoked, so in this operation the surgeon deliberately endangers his patient, and then, with incredible speed and celerity, rescues him from death at the last possible split second ... "Did any of you ever see Doctor Tetrazzini perform? I say perform advisedly because his operations were performances. He would start by throwing a scalpel across the room into the patient and then make his entrance like a ballet dancer. His speed was incredible: `I don't give them time to die,' he would say. Tumors put him in a frenzy of rage. `Fucking undisciplined cells!' he would snarl, advancing on the tumor like a knife-fighter.

If by 2050 medical advances make it possible to slow down ageing processes and significantly extend human lifespans, will the new treatments be available to all 10 billion humans on the planet, or just to a few billionaires?

We know that media vita in morte sumus or, “in the midst of life we are in death.” We begin dying the day we are born, after all. But because of advances in medical science, the majority of Americans will spend the later years of their life actively dying. The fastest-growing segment of the US population is over eighty-five, what I would call the aggressively elderly. If you reach eighty-five, not only is there a strong chance you are living with some form of dementia or terminal disease, but statistics show that you have a 50-50 chance of ending up in a nursing home, raising the question of whether a good life is measured in quality or quantity. This slow decline differs sharply from times past, when people tended to die quickly, often in a single day. Postmortem daguerreotypes from the 1800s picture fresh, young, almost lifelike corpses, many of them victims of scarlet fever or diphtheria. In 1899, a mere 4 percent of the US population was over sixty-five—forget making it to eighty-five. Now, many will know that death is coming during months or years of deterioration. Medicine has given us the “opportunity”—loosely defined—to sit at our own wakes.

Kovacs, I hate these goddamn freaks. They’ve been grinding us down for the best part of two and a half thousand years. They’ve been responsible for more misery than any other organisation in history. You know they won’t even let their adherents practise birth control, for Christ’s sake, and they’ve stood against every significant medical advance of the last five centuries. Practically the only thing you can say in their favour is that this d.h.f. thing has stopped them from spreading with the rest of humanity.

What prompts alarm in me is how you and your government want to ruin not only the potential of this of this country, but also the path of those who are going to transition into more advanced beings in search of immortality and omnipotence, and maybe even participate in a great singularity. These advances are going to pass, one way or another. And your current second-rate moral system—your weak, pretend-God-will-take-care-of-us bullshit—is a waste for our species' possibilities. You people want to pretend that democracy, religious inspiration, and unbridled consumerism are going to last forever and carry us all to bliss; that the American Dream is right around the next corner for everyone. you spend hundreds of billions of dollars on lazy welfare recipients, on mentally challenged people, on uneducated repeat criminals, on obese second-rate citizens bankrupting our medical system, on murderous war machines fighting for oil and your oligarchy's pet projects in far off places. All so you maintain your puny forms of power and sleep better at night.

The idea that he’d be entering this world involuntarily—the enhancers’ realm, the political imbroglio—disturbed him. That he’d have to claim a stance, take a side, defend the technological advances by virtue of their medical purpose. Be grouped with the believers by default. He

Ethical AI systems must learn not to discriminate or manipulate anyone based on race, color, religion, gender, age, national origin, marital status, social status, genetics, or medical information. Must understand its own misuse or misconduct limits and recertification mechanisms.

If your deepest self is singing and coaxing you straight toward the bonfire, is it better to turn away? Stop your ears with wax? Ignore all the perverse glory your heart is screaming at you? Set yourself on the course that will lead you dutifully towards the norm, reasonable hours and regular medical check-ups, stable relationships and steady career advancement, the New York Times and brunch on Sunday, all with the promise of being somehow a better person? Or—like Boris—is it better to throw yourself head first and laughing into the holy rage calling your name? It’s

To my thinking the greatest advance in recorded medical history is the thirty-minute walk before breakfast. Premiums for life insurance are usually paid for the benefit of someone else. If you want any life insurance for yourself you had better pay the daily premium of a thirty-minute walk.

The Tree of Life was an ancient symbol of interconnection, fertility, and eternal life—precisely because of this legendary tree’s fruit. Fruit is part of our essence, a basic element of who we are. We cannot survive without fruit on this planet. It outweighs the nutrition of any other food. Yet the current “health” movement toward low-carb diets has put fruit on the endangered species list, with the goal of making it extinct. Is this denial? Ignorance? Foolishness? We’re not talking about uneducated people who are driving the trend. We’re talking about smart, highly intelligent professionals with advanced degrees in medicine and nutrition. If they’re advising patients to shun fruit, it must be because of their training, the misinformation out there, or their own selective interests. Have you heard of book burning? If the anti-sugar war keeps up its momentum, fruit trees will be next to go up in flames.

In 1980 there was no Internet or cell phone network, most people did not travel by air, most of the advanced medical technologies in common use today did not yet exist, and only a minority attended college. In the areas of communication, transportation, health, and education, the changes have been profound.

I’ve heard of movie stars and Pop Idols getting plastic surgery to change their looks drastically, but I’m not sure if I would want to do something like that,” I said. “I prefer to be natural…the way I was born.” Auntabelle nodded in agreement. “I’m all for technological and medical advancement but when it comes to altering yourself so much because you don’t like the way you were born or because you simply don’t like yourself the way you are, that you become a completely different person, then I’m not in support of it. I wouldn’t want to use my technology to alter someone so much they are no longer their own self.

Over the next few months, I set out to understand why in our country with the most expensive and advanced medical technology in the world, growing numbers of American women, disproportionately Black women, were dying as a result of pregnancy and childbirth, including African American women whose income and education should protect them.

Psychologists often make a distinction between mistakes where we already know the right answer and mistakes where we don’t. A medication error, for example, is a mistake of the former kind: the nurse knew she should have administered Medicine A but inadvertently administered Medicine B, perhaps because of confusing labeling combined with pressure of time. But sometimes mistakes are consciously made as part of a process of discovery. Drug companies test lots of different combinations of chemicals to see which have efficacy and which don’t. Nobody knows in advance which will work and which won’t, but this is precisely why they test extensively, and fail often. It is integral to progress.

One could argue that these Japanese atrocities carried out were typical of the chaos and brutality that often accompany warfare; but this cannot be said for Unit 731. Much like their counterparts in Nazi Germany did in the Auschwitz Concentration Camp, the Japanese experimented on humans like lab rats, all in the name of medical and military advancement.

MODERN SCIENTIFIC CAPABILITY has profoundly altered the course of human life. People live longer and better than at any other time in history. But scientific advances have turned the processes of aging and dying into medical experiences, matters to be managed by health care professionals. And we in the medical world have proved alarmingly unprepared for it.

In the United States medical treatment is the third highest cause of death (iatrogenic death) after cancer and heart disease. So, despite our undoubted progress in understanding the chemistry and biological structure of the body, and great advances in the techniques of medical intervention, we are not exceeding the achievements of medieval doctors as much as we might expect. In their terms we are doing worse, because the objective of their care was not necessarily to save the body (which would, of course, be wonderful) but to help save the soul by allowing patients to know the hour of their death, and prepare for it. This was itself a genuine medical skill and, again, one that depended on seeing the patient as a human being.

The longevity genes I work on are called “sirtuins,” named after the yeast SIR2 gene, the first one to be discovered. There are seven sirtuins in mammals, SIRT1 to SIRT7, and they are made by almost every cell in the body. When I started my research, sirtuins were barely on the scientific radar. Now this family of genes is at the forefront of medical research and drug development. Descended from gene B in M. superstes, sirtuins are enzymes that remove acetyl tags from histones and other proteins and, by doing so, change the packaging of the DNA, turning genes off and on when needed. These critical epigenetic regulators sit at the very top of cellular control systems, controlling our reproduction and our DNA repair. After a few billion years of advancement since the days of yeast, they have evolved to control our health, our fitness, and our very survival. They have also evolved to require a molecule called nicotinamide adenine dinucleotide, or NAD. As we will see later, the loss of NAD as we age, and the resulting decline in sirtuin activity, is thought to be a primary reason our bodies develop diseases when we are old but not when we are young.

...I suppose it is a lingering trace of Plutarch and my ineradicable boyish imagination that at bottom our State should be wise, sane, and dignified, that makes me think a country which leaves its medical and literary criticism, or indeed any such vitally important criticism, entirely to private enterprise and open to the advances of any purchaser much be in a frankly hopeless condition.

The IRF had just been completed, after nine years of construction. The facility is part of the National Institute of Allergy and Infectious Diseases, which in turn is a part of the National Institutes of Health, or NIH. The IRF’s mission is to develop experimental drugs and vaccines, called medical countermeasures, that could defeat lethal emerging viruses and advanced biological weapons.

Faster than light space travel to distant galaxies has been proven impossible. The existence of other planets or alien races, therefore, remains mere conjecture as these cannot be reached or contacted. Miraculous machines that let you travel backward or forward in time are impossible – an unsolvable paradox. Teleportation, precognition, telekinesis, and all versions of extrasensory perception have all been scientifically disproven. Technological and medical advancements have allowed people to live longer and better but there is no sufficiently advanced technology that has freed mankind from tedious labor, eventual suffering, or death. Most inhabitants of the developed world go to work every morning, where they sit for several hours in front of blinking screens, and then return home to sit in front of other, bigger screens.

Faye keeps forgetting what she'll be giving up if she decides to stay here. Access to modern medicine, for starters. In 2015 people can survive cancer, tuberculosis, scarlet fever. Vaccines eradicated polio and measles. Do you really want to live in a world with iron lungs and polio, Faye? Do you?” “I guess I could go back to 2015 and live in a world with meth, heroin, terrorism, HIV and Ebola. Huge improvement, right?

What if the heart, for its own unfathomable reasons, leads one willfully and in a cloud of unspeakable radiance away from health, domesticity, civic responsibility and strong social connections and all the blandly-held common virtues and instead straight towards a beautiful flare of ruin, self-immolation, disaster? Is Kitsey right? If your deepest self is singing and coaxing you straight toward the bonfire, is it better to turn away? Ignore all the perverse glory your heart is screaming at you? Set yourself on the course that will lead you dutifully towards the norm, reasonable hours and regular medical check-ups, stable relationships and steady career advancement, the New York Times and brunch on Sunday, all with the promise of being somehow a better person? Or is it better to throw yourself head first and laughing into the holy rage calling your name?

In the early 1700s, this mirrored the situation in England and the rest of Europe, but medicine on the Continent began to undergo modernizing changes, although these were very slow to cross the Atlantic. Europe began to embrace public-health measures and medical advances such as widespread vaccination, scientific medical education, and the rise of the hospital, but American progress lagged behind, especially in the insular South. The

advances in AI are poised to drive dramatic productivity increases and perhaps eventually full automation. Radiologists, for example, are trained to interpret the images that result from various medical scans. Image processing and recognition technology is advancing rapidly and may soon be able to usurp the radiologist’s traditional role. Software can already recognize people in photos posted on Facebook and even help identify potential terrorists in airports.

Looking beneath the history of one's country is like learning that alcoholism or depression runs in one's family or that suicide has occurred more often than might be usual or, with the advances of medical genetics, discovering that one has inherited the markers of BRCA mutation for breast cancer. You don't ball up in the corner with guilt or shame at these discoveries. You don't if your wise, forbit any mention of them. In fact you do the opposite. You educate yourself.

At that moment, for some reason, the enormity of death began to hit me. I'm not sure why. I had never focused on dying before, Annabelle. I pushed the idea away. We all know we are going to die, but deep down, we don't believe it. We secretly think there will be a late reprieve, a medical advance, a new drug that staves off our mortality. It's an illusion, of course, something to shield us from our fear of the unknown. But it only works until death presents itself so plainly that you cannot ignore it.

If your deepest self is singing and coaxing you straight toward the bonfire, is it better to turn away? Stop your ears with wax? Ignore all the perverse glory your heart is screaming at you? Set yourself on the course that will lead you dutifully towards the norm, reasonable hours and regular medical check-ups, stable relationships and steady career advancement, the New York Times and brunch on Sunday, all with the promise of being somehow a better person? Or—like Boris—is it better to throw yourself head

Kovacs, I hate these goddamn freaks. They’ve been grinding us down for the best part of two and a half thousand years. They’ve been responsible for more misery than any other organization in history. You know they won’t even let their adherents practice birth control, for Christ’s sake, and they’ve stood against every significant medical advance of the last five centuries. Practically the only thing you can say in their favor is that this D.H.F. thing has stopped them from spreading with the rest of humanity.

I’ve now interviewed a couple hundred researchers in the United States, Britain, France, Germany, Japan, and China. I visited Walter Reed National Military Medical Center, where I met brain-injured veterans. I went to the San Francisco offices of Lumosity, the biggest online provider of these cognitive games aimed at improving intelligence. And I met twice with the guy who leads the funding in this area at the Intelligence Advanced Research Projects Activity, or IARPA. It’s a government intelligence agency, like DARPA for spies.

The situation with regard to insulin is particularly clear. In many parts of the world diabetic children still die from lack of this hormone. ... [T]hose of us who search for new biological facts and for new and better therapeutic weapons should appreciate that one of the central problems of the world is the more equitable distribution and use of the medical and nutritional advances which have already been established. The observations which I have recently made in parts of Africa and South America have brought this fact very forcible to my attention.

Grant never wavered in his commitment to freed people. It would be army commanders in the field, not Washington politicians, who worked out many of the critical details in caring for the recently enslaved. Frederick Douglass never forgot the service Grant rendered to his people, arguing that General Grant “was always up with, or in advance of authority furnished from Washington in regard to the treatment of those of our color then slaves,” and he cited the food, work, medical care, and education Grant supplied in the months before the official Emancipation Proclamation.34

Through weeks of symptoms and months of tests, they didn’t want to believe it was what it was. But once they accepted, deeper was their only way forward too. They stayed up all night doing advanced medical research they couldn’t begin to understand. They joined support groups and read books and bought T-shirts and ran 5Ks. They rededicated their lives to what they’d rejected utterly only days before. And then when their story strayed from that path – the cure didn’t work, the cure worked too well, the indicators indicated something else instead – they found themselves more lost than ever.

The idea that germline editing was “unnatural” began to recede in her thinking. All medical advances attempt to correct something that happened “naturally,” she realized. “Sometimes nature does things that are downright cruel, and there are many mutations that cause enormous suffering, so the idea that germline editing was unnatural began to carry less weight for me,” she says. “I am not sure how to make a sharp distinction in medicine between what is natural and what is unnatural, and I think it’s dangerous to use that dichotomy to block something that could alleviate suffering and disability.

This is something that has been going on forever,” Craig Spencer, the director of global health in emergency medicine at Columbia University, says about the variability of human response to infection. “I wouldn’t be surprised if people are walking about with long Epstein-Barr virus, or long influenza. We all know someone who is low energy, who’s told to work harder. We have all heard about chronic Lyme sufferers, and those with ME/CFS. But they get written off.” Spencer understands something about how infections can do long-term damage, because he contracted Ebola while working in Guinea, fell ill upon his return to New York City, and then struggled with the virus’s ongoing effects. (Studies have suggested that the Ebola virus may linger in the body for years.) The difference between long COVID and other infection-associated illnesses is that it is happening “on such a huge scale—unlike anything we’ve seen before. It is harder for the medical community to write off,” Spencer told me. Indeed, many researchers I spoke with for this book hope that the race to understand long COVID will advance our understanding of other chronic conditions that follow infection, transforming medicine in the process.

Ours is the age of atomic power but also of nuclear proliferation, of globalized trade but also worldwide terrorism, of instant communication but also fragmented communities, of free association but also marital failure, of limitless mobility but also homogenized destinations, of open borders but also confused identities, of astounding medical advances but also greater worries about health, of longer and more vigorous lives but also protracted and more miserable deaths, of unprecedented freedom and prosperity but also remarkable anxiety about our future, both personal and national. In our age of heightened expectations

In 1980 there was no Internet or cell phone network, most people did not travel by air, most of the advanced medical technologies in common use today did not yet exist, and only a minority attended college. In the areas of communication, transportation, health, and education, the changes have been profound. These changes have also had a powerful impact on the structure of employment: when output per head increases by 35 to 50 percent in thirty years, that means that a very large fraction—between a quarter and a third—of what is produced today, and therefore between a quarter and a third of occupations and jobs, did not exist thirty years ago.

Another huge boost can be attributed to vaccines. In 1921, America had about 200,000 cases of diphtheria; by the early 1980s, with vaccination, that had fallen to just 3. In roughly the same period, whooping cough and measles infections fell from about 1.1 million cases a year to just 1,500. Before vaccines, 20,000 Americans a year got polio. By the 1980s, that had dropped to 7 a year. According to the British Nobel laureate Max Perutz, vaccinations might have saved more lives in the twentieth century even than antibiotics. The one thing no one doubted was that practically all the credit for the great advances lay securely with medical science.

Say Goodbye to Fingersticks & hello to Continuous Glucose Monitoring Systems Living with diabetes is a daily challenge, requiring individuals to closely monitor their blood glucose levels to maintain stable health. Fortunately, advancements in medical technology have revolutionized diabetes management, with one such innovation being Continuous Glucose Monitoring (CGM) systems. CGM has become a game-changer for diabetics, providing real-time data and insights that enable better control of blood sugar levels and, ultimately, a higher quality of life. In this article, we will explore the benefits of Continuous Glucose Monitoring and how it has transformed diabetes management for the better.

Like evolution itself, there have been rapid advances and crippling setbacks along the way. If the Library of Alexandria had never been burned to the ground it is possible to imagine that we would have built upon the achievements of the ancient Greeks to greater and earlier effect, and therefore it could have been in the time of a Cardano or a Newton or a Pascal that we first put a man on the moon. And we can only wonder where we would be. And at the planets we would have terraformed and colonised by the twenty-first century. Which medical advances we would have made. Maybe if there had been no dark ages, no switching off of the light, we would have found a way never to grow old, to never die.

We are under a deception similar to that which misleads the traveler in the Arabian desert. Beneath the caravan all is dry and bare; but far in advance, and far in the rear, is the semblance of refreshing waters... A similar illusion seems to haunt nations through every stage of the long progress from poverty and barbarism to the highest degrees of opulence and civilization. But if we resolutely chase the mirage backward, we shall find it recede before us into the regions of fabulous antiquity. It is now the fashion to place the golden age of England in times when noblemen were destitute of comforts the want of which would be intolerable to a modern footman, when farmers and shopkeepers breakfasted on loaves the very sight of which would raise a riot in a modern workhouse, when to have a clean shirt once a week was a privilege reserved for the higher class of gentry, when men died faster in the purest country air than they now die in the most pestilential lanes of our towns, and when men died faster in the lanes of our towns than they now die on the coast of Guiana. ... We too shall in our turn be outstripped, and in our turn be envied. It may well be, in the twentieth century, that the peasant of Dorsetshire may think himself miserably paid with twenty shillings a week; that the carpenter at Greenwich may receive ten shillings a day; that laboring men may be as little used to dine without meat as they are now to eat rye bread; that sanitary police and medical discoveries may have added several more years to the average length of human life; that numerous comforts and luxuries which are now unknown, or confined to a few, may be within the reach of every diligent and thrifty workingman. And yet it may then be the mode to assert that the increase of wealth and the progress of science have benefited the few at the expense of the many, and to talk of the reign of Queen Victoria as the time when England was truly merry England, when all classes were bound together by brotherly sympathy, when the rich did not grind the faces of the poor, and when the poor did not envy the splendor of the rich.

Given the central place that technology holds in our lives, it is astonishing that technology companies have not put more resources into fixing this global problem. Advanced computer systems and artificial intelligence (AI) could play a much bigger role in shaping diagnosis and prescription. While the up-front costs of using such technology may be sizeable, the long-term benefits to the health-care system need to be factored into value assessments. We believe that AI platforms could improve on the empirical prescription approach. Physicians work long hours under stressful conditions and have to keep up to date on the latest medical research. To make this work more manageable, the health-care system encourages doctors to specialize. However, the vast majority of antibiotics are prescribed either by generalists (e.g., general practitioners or emergency physicians) or by specialists in fields other than infectious disease, largely because of the need to treat infections quickly. An AI system can process far more information than a single human, and, even more important, it can remember everything with perfect accuracy. Such a system could theoretically enable a generalist doctor to be as effective as, or even superior to, a specialist at prescribing. The system would guide doctors and patients to different treatment options, assigning each a probability of success based on real-world data. The physician could then consider which treatment was most appropriate.

The three most important Arab witnesses of the French occupation were the historians Abd al-Rahman al-Jabartī, Hasan al-Attar and Niqula Turk. Al-Jabartī felt that the invasion was God’s punishment on Egypt for ignoring Islamic principles. He saw the French as the new Crusaders, but made no secret of his admiration for French weaponry, military tactics, medical advances, scientific achievements and interest in Egyptian history, geography and culture. He enjoyed his interaction with the savants and was impressed by Napoleon’s lack of ostentation and the way that on his journey to Suez he took engineers and Muslim merchants with him instead of cooks and a harem. Yet still he saw him as a rapacious, untrustworthy, atheistic beast, and was delighted when jihad was declared against the infidels.62

Looking beneath the history of one’s country is like learning that alcoholism or depression runs in one’s family or that suicide has occurred more often than might be usual or, with the advances in medical genetics, discovering that one has inherited the markers of a BRCA mutation for breast cancer. You don’t ball up in a corner with guilt or shame at these discoveries. You don’t, if you are wise, forbid any mention of them. In fact, you do the opposite. You educate yourself. You talk to people who have been through it and to specialists who have researched it. You learn the consequences and obstacles, the options and treatment. You may pray over it and meditate over it. Then you take precautions to protect yourself and succeeding generations and work to ensure that these things, whatever they are, don’t happen again.

When I got home, I thought about the fact that Einstein supposedly used to stock his wardrobe with the same suits and shoes so he’d never have to think about what he was going to wear. I lack the intellect it takes to solve problems that way. I’ve advanced nothing in the field of psychology, and my paper on PTSD was given little attention; I wrote that psychological disorders with a genetic link, such as borderline personality disorder, might seem impossible to treat, while PTSD, which is based in trauma that has been experienced, seems easy to tackle, at least to the layperson. The opposite is true. It can be difficult to find the right medication for genetic disorders, but they can be sufficiently treated. Conversely, PTSD never goes away. One might think that our genes are so elementary that we cannot escape them, but our experiences have the ability to do far greater damage.

What if one happens to be possessed of a heart that can't be trusted--? What if the heart, for its own unfathomable reasons, leads one willfully and in a cloud of unspeakable radiance away from health, domesticity, civic responsibility and strong social connections and all the blandly-held common virtues and instead straight toward a beautiful flare of ruin, self-immolation, disaster?...If your deepest self is singing and coaxing you straight toward the bonfire, is it better to turn away? Stop your ears with wax? Ignore all the perverse glory your heart is screaming at you? Set yourself on the course that will lead you dutifully towards the norm, reasonable hours and regular medical check-ups, stable relationships and steady career advancement the New York Times and brunch on Sunday, all with the promise of being somehow a better person? Or...is it better to throw yourself head first and laughing into the holy rage calling your name?

What if one happens to be possessed of a heart that can't be trusted - ? What if the hearts, for its own unfathomable reasons, leads one willfully and in a cloud of unspeakable radiance away from health, domesticity, civic responsibility and strong social connections and all the blandly-held common virtues and instead straight towards a beautiful flare of ruin, self-immolation, disaster? Is Kitsey right? If your deepest self is singing and coaxing you straight toward the bonfire, is it better to turn away? Stop your ears with wax? Ignore all the perverse glory your heart is screaming at you? Set yourself on the course that will lead you dutifully towards the norm, reasonable hours and regular medical check-ups, stable relationships and steady career advancement, the New York Times and brunch on Sunday, all with the promise of being somehow a better person? Or - like Boris - is it better to throw yourself head first and laughing into the holy rage calling your name?

This is related to the phenomenon of the Professional Smile, a national pandemic in the service industry; and noplace in my experience have I been on the receiving end of as many Professional Smiles as I am on the Nadir, maître d’s, Chief Stewards, Hotel Managers’ minions, Cruise Director—their P.S.’s all come on like switches at my approach. But also back on land at banks, restaurants, airline ticket counters, on and on. You know this smile—the strenuous contraction of circumoral fascia w/ incomplete zygomatic involvement—the smile that doesn’t quite reach the smiler’s eyes and that signifies nothing more than a calculated attempt to advance the smiler’s own interests by pretending to like the smilee. Why do employers and supervisors force professional service people to broadcast the Professional Smile? Am I the only consumer in whom high doses of such a smile produce despair? Am I the only person who’s sure that the growing number of cases in which totally average-looking people suddenly open up with automatic weapons in shopping malls and insurance offices and medical complexes and McDonald’ses is somehow causally related to the fact that these venues are well-known dissemination-loci of the Professional Smile? Who do they think is fooled by the Professional Smile? And yet the Professional Smile’s absence now also causes despair. Anybody who’s ever bought a pack of gum in a Manhattan cigar store or asked for something to be stamped FRAGILE at a Chicago post office or tried to obtain a glass of water from a South Boston waitress knows well the soul-crushing effect of a service worker’s scowl, i.e. the humiliation and resentment of being denied the Professional Smile. And the Professional Smile has by now skewed even my resentment at the dreaded Professional Scowl: I walk away from the Manhattan tobacconist resenting not the counterman’s character or absence of goodwill but his lack of professionalism in denying me the Smile. What a fucking mess.

Only here's what I really, really want someone to explain to me. What if one happens to be possessed of a heart that can't be trusted--? What if the heart, for its own unfathomable reasons, leads one willfully and in a cloud of unspeakable radiance away from health, domesticity, civic responsibility and strong social connections and all the blandly-held common virtues and instead straight toward a beautiful flare of ruin, self-immolation, disaster?...If your deepest self is singing and coaxing you straight toward the bonfire, is it better to turn away? Stop your ears with wax? Ignore all the perverse glory your heart is screaming at you? Set yourself on the course that will lead you dutifully towards the norm, reasonable hours and regular medical check-ups, stable relationships and steady career advancement the New York Times and brunch on Sunday, all with the promise of being somehow a better person? Or...is it better to throw yourself head first and laughing into the holy rage calling your name?

Only here’s what I really, really want someone to explain to me. What if one happens to be possessed of a heart that can’t be trusted—? What if the heart, for its own unfathomable reasons, leads one willfully and in a cloud of unspeakable radiance away from health, domesticity, civic responsibility and strong social connections and all the blandly-held common virtues and instead straight towards a beautiful flare of ruin, self-immolation, disaster? Is Kitsey right? If your deepest self is singing and coaxing you straight toward the bonfire, is it better to turn away? Stop your ears with wax? Ignore all the perverse glory your heart is screaming at you? Set yourself on the course that will lead you dutifully towards the norm, reasonable hours and regular medical check-ups, stable relationships and steady career advancement, the New York Times and brunch on Sunday, all with the promise of being somehow a better person? Or—like Boris—is it better to throw yourself head first and laughing into the holy rage calling your name?

Perhaps nowhere is modern chemistry more important than in the development of new drugs to fight disease, ameliorate pain, and enhance the experience of life. Genomics, the identification of genes and their complex interplay in governing the production of proteins, is central to current and future advances in pharmacogenomics, the study of how genetic information modifies an individual's response to drugs and offering the prospect of personalized medicine, where a cocktail of drugs is tailored to an individual's genetic composition. Even more elaborate than genomics is proteomics, the study of an organism's entire complement of proteins, the entities that lie at the workface of life and where most drugs act. Here computational chemistry is in essential alliance with medical chemistry, for if a protein implicated in a disease can be identified, and it is desired to terminate its action, then computer modelling of possible molecules that can invade and block its active site is the first step in rational drug discovery. This too is another route to the efficiencies and effectiveness of personalized medicine.

Now, although hypertension is accentuated by modern civilisation, it is not specifically a disease of civilisation. It is a disease of consciousness—that is, of being human. The farm labourer going to work is as likely to ignore his surroundings as the harassed car salesman. And if the inhabitants of some Amazon village are ‘closer to nature’ than New Yorkers, this is usually at the cost of dirt and ignorance and inconvenience. Hypertension is the price we pay for the symphonies of Beethoven, the novels of Balzac, the advances in medical knowledge that prevent children dying of smallpox. However, it is not a necessary and inescapable price. It is the result of ignorance, of bad management of our vital economy. The point to observe here is that although hypertension may not be necessary, it is as widespread as the common cold. It would not be inaccurate to say that all human beings live in a state of ‘vigilance’ and anxiety that is far above the level they actually need for vital efficiency. It is a general tendency of consciousness to ‘spread the attention too thinly’; and, like an over-excited child with too many toys on Christmas Day, the result is nervous exhaustion.

When in doubt, what to do? How do we know what's right for us? Every shrink, every career counselor, every Disney princess knows the answer: "Be yourself." "Follow your heart." Only here's what I really, really want someone to explain to me. What if one happens to be possessed of a heart that can't be trusted—? What if the heart, for its own unfathomable reasons, leads one willfully and in a cloud of unspeakable radiance away from health, domesticity, civic responsibility and strong social connections and all the blandly-held common virtues and instead straight toward a beautiful flare of ruin, self-immolation, disaster?... If your deepest self is singing and coaxing you straight toward the bonfire, is it better to turn away? Stop your ears with wax? Ignore all the perverse glory your heart is screaming at you? Set yourself on the course that will lead you dutifully towards the norm, reasonable hours and regular medical check-ups, stable relationships and steady career advancement the New York Times and brunch on Sunday, all with the promise of being somehow a better person? Or... is it better to throw yourself head first and laughing into the holy rage calling your name?

When in doubt, what to do? How do we know what's right for us? Every shrink, every career counselor, every Disney princess knows the answer: "Be yourself." "Follow your heart." Only here's what I really, really want someone to explain to me. What if one happens to be possessed of a heart that can't be trusted—? What if the heart, for its own unfathomable reasons, leads one willfully and in a cloud of unspeakable radiance away from health, domesticity, civic responsibility and strong social connections and all the blandly-held common virtues and instead straight toward a beautiful flare of ruin, self-immolation, disaster?... If your deepest self is singing and coaxing you straight toward the bonfire, is it better to turn away? Stop your ears with wax? Ignore all the perverse glory your heart is screaming at you? Set yourself on the course that will lead you dutifully towards the norm, reasonable hours and regular medical check-ups, stable relationships and steady career advancement, the New York Times and brunch on Sunday, all with the promise of being somehow a better person? Or... is it better to throw yourself head first and laughing into the holy rage calling your name?

There is no guarantee that a socialized economy will always succeed. The state-owned economies of Eastern Europe and the former Soviet Union suffered ultimately fatal distortions in their development because of the backlog of poverty and want in the societies they inherited; years of capitalist encirclement, embargo, invasion, devastating wars, and costly arms buildup; poor incentive systems, and a lack of administrative initiative and technological innovation; and a repressive political rule that allowed little critical feedback while fostering stagnation and elitism. Despite all that, the former communist states did transform impoverished countries into relatively advanced societies. Whatever their mistakes and political crimes, they achieved—in countries that were never as rich as ours—what U.S. free-market capitalism cannot and has no intention of accomplishing: adequate food, housing, and clothing for all; economic security in old age; free medical care; free education at all levels; and a guaranteed income. Today by overwhelming majorities, people in Russia and other parts of Eastern Europe say that life was better under communism than under the present freemarket system.

What if one happens to be possessed of a heart that can’t be trusted—? What if the heart, for its own unfathomable reasons, leads one willfully and in a cloud of unspeakable radiance away from health, domesticity, civic responsibility and strong social connections and all the blandly-held common virtues and instead straight towards a beautiful flare of ruin, self-immolation, disaster? Is Kitsey right? If your deepest self is singing and coaxing you straight toward the bonfire, is it better to turn away? Stop your ears with wax? Ignore all the perverse glory your heart is screaming at you? Set yourself on the course that will lead you dutifully towards the norm, reasonable hours and regular medical check-ups, stable relationships and steady career advancement, the New York Times and brunch on Sunday, all with the promise of being somehow a better person? Or—like Boris—is it better to throw yourself head first and laughing into the holy rage calling your name? It’s not about outward appearances but inward significance. A grandeur in the world, but not of the world, a grandeur that the world doesn’t understand. That first glimpse of pure otherness, in whose presence you bloom out and out and out. A self one does not want. A heart one cannot help.

So he's right?" Sophia said. "From what I've read, yes. That was known back when you were...Never mind...Just...Technically he is right. Over." "Ick," Sophia said. "I just...Maybe calling you wasn't the best choice, Da. Over." "I'm glad you did. We never get to talk. But, I've got to get this straight. This Walker guy thinks she got pregnant from involuntary emissions on the damp bottom of a lifeboat? Over." "Yes," Sophia said. "She's...virgo intacta. And they're both...Like Olga said, only virgins could be that incoherent about it. Over." "You're not particularly incoherent about it, over." "You've been talking to us about it since we were kids in one way or another," Sophia said. "And let's just say this cruise has been a real eye-opener." "I'd say sorry but I didn't start the Plague. Okay, Walker. What's his medical background, over?" "I'm not sure," Sophia said. "He said he took a course once that included advanced midwifery. I'm not even sure what that means except it has to do with delivering babies." "God knows we're going to need it. Okay, I'm going to get the CDC to call you and see if they can confirm what you've said. I'm also going to pass this around in the official news bulletin. Over." "Uh, isn't this a little private, Da?" Sophia asked. "Well, it's that or every little old lady on the Boadicea will be beating him with their canes. Squadron, out.

When we go to the doctor, he or she will not begin to treat us without taking our history—and not just our history but that of our parents and grandparents before us. The doctor will not see us until we have filled out many pages on a clipboard that is handed to us upon arrival. The doctor will not hazard a diagnosis until he or she knows the history going back generations. As we fill out the pages of our medical past and our current complaints, what our bodies have been exposed to and what they have survived, it does us no good to pretend that certain ailments have not beset us, to deny the full truths of what brought us to this moment. Few problems have ever been solved by ignoring them. Looking beneath the history of one’s country is like learning that alcoholism or depression runs in one’s family or that suicide has occurred more often than might be usual or, with the advances in medical genetics, discovering that one has inherited the markers of a BRCA mutation for breast cancer. You don’t ball up in a corner with guilt or shame at these discoveries. You don’t, if you are wise, forbid any mention of them. In fact, you do the opposite. You educate yourself. You talk to people who have been through it and to specialists who have researched it. You learn the consequences and obstacles, the options and treatment. You may pray over it and meditate over it. Then you take precautions to protect yourself and succeeding generations and work to ensure that these things, whatever they are, don’t happen again.

We have a crisis in this nation, and it has nothing to do with regulatory reform or marginal tax rates. This book is not going to be about politics. (Sorry to disappoint.) It’s about something deeper and more meaningful. Something a little harder to quantify but a lot more personal. Despite the astonishing medical advances and technological leaps of recent years, average life span is in decline in America for the third year in a row. This is the first time our nation has had even a two-year drop in life expectancy since 1962—when the cause was an influenza epidemic. Normally, declines in life expectancy are due to something big like that—a war, or the return of a dormant disease. But what’s the “big thing” going on in America now? What’s killing all these people? The 2016 data point to three culprits: Alzheimer’s, suicides, and unintentional injuries—a category that includes drug and alcohol–related deaths. Two years ago, 63,632 people died of overdoses. That’s 11,000 more than the previous year, and it’s more than the number of Americans killed during the entire twenty-year Vietnam War. It’s almost twice the number killed in automobile accidents annually, which had been the leading American killer for decades. In 2016, there were 45,000 suicides, a thirty-year high—and the sobering climb shows no signs of abating: the percentage of young people hospitalized for suicidal thoughts and actions has doubled over the past decade.1 We’re killing ourselves, both on purpose and accidentally. These aren’t deaths from famine, or poverty, or war. We’re literally dying of despair.

Each generation identifies with a small group of people said to have lived lives exemplifying the vices and virtues of that generation. If one were to choose a trial lawyer whose life reflected the unique characteristics of America’s “Wild West” of a criminal justice system in the latter half of the Twentieth Century, that person likely would be my father. New York City of the 1960s until the turn of the 21st century was the world’s epicenter of organized and white-collar crime. During those four decades, the most feared mafia chiefs, assassins, counterfeiters, Orthodox Jewish money launderers, defrocked politicians of every stripe, and Arab bankers arriving in the dead of night in their private jets, sought the counsel of one man: my father, Jimmy La Rossa. Once a Kennedy-era prosecutor, Brooklyn-born Jimmy La Rossa became one of the greatest criminal trial lawyers of his day. He was the one man who knew where all of the bodies were buried, and everyone knew it. It seemed incomprehensible that Jimmy would one day just disappear from New York. Forever. After stealing my dying father from New York Presbyterian Hospital to a waiting Medevac jet, the La Rossa Boys, as we became known, spent the next five years in a place where few would look for two diehard New Yorkers: a coastal town in the South Bay of Los Angeles, aptly named Manhattan Beach. While I cooked him his favorite Italian dishes and kept him alive using the most advanced medical equipment and drugs, my father and I documented our notorious and cinematic life together as equal parts biography and memoir. This is our story.

Gadgetry will continue to relieve mankind of tedious jobs. Kitchen units will be devised that will prepare ‘automeals,’ heating water and converting it to coffee; toasting bread; frying, poaching or scrambling eggs, grilling bacon, and so on. Breakfasts will be ‘ordered’ the night before to be ready by a specified hour the next morning. Communications will become sight-sound and you will see as well as hear the person you telephone. The screen can be used not only to see the people you call but also for studying documents and photographs and reading passages from books. Synchronous satellites, hovering in space will make it possible for you to direct-dial any spot on earth, including the weather stations in Antarctica. [M]en will continue to withdraw from nature in order to create an environment that will suit them better. By 2014, electroluminescent panels will be in common use. Ceilings and walls will glow softly, and in a variety of colors that will change at the touch of a push button. Robots will neither be common nor very good in 2014, but they will be in existence. The appliances of 2014 will have no electric cords, of course, for they will be powered by long- lived batteries running on radioisotopes. “[H]ighways … in the more advanced sections of the world will have passed their peak in 2014; there will be increasing emphasis on transportation that makes the least possible contact with the surface. There will be aircraft, of course, but even ground travel will increasingly take to the air a foot or two off the ground. [V]ehicles with ‘Robot-brains’ … can be set for particular destinations … that will then proceed there without interference by the slow reflexes of a human driver. [W]all screens will have replaced the ordinary set; but transparent cubes will be making their appearance in which three-dimensional viewing will be possible. [T]he world population will be 6,500,000,000 and the population of the United States will be 350,000,000. All earth will be a single choked Manhattan by A.D. 2450 and society will collapse long before that! There will, therefore, be a worldwide propaganda drive in favor of birth control by rational and humane methods and, by 2014, it will undoubtedly have taken serious effect. Ordinary agriculture will keep up with great difficulty and there will be ‘farms’ turning to the more efficient micro-organisms. Processed yeast and algae products will be available in a variety of flavors. The world of A.D. 2014 will have few routine jobs that cannot be done better by some machine than by any human being. Mankind will therefore have become largely a race of machine tenders. Schools will have to be oriented in this direction…. All the high-school students will be taught the fundamentals of computer technology will become proficient in binary arithmetic and will be trained to perfection in the use of the computer languages that will have developed out of those like the contemporary “Fortran". [M]ankind will suffer badly from the disease of boredom, a disease spreading more widely each year and growing in intensity. This will have serious mental, emotional and sociological consequences, and I dare say that psychiatry will be far and away the most important medical specialty in 2014. [T]he most glorious single word in the vocabulary will have become work! in our a society of enforced leisure.

In the introduction, I wrote that COVID had started a war, and nobody won. Let me amend that. Technology won, specifically, the makers of disruptive new technologies and all those who benefit from them. Before the pandemic, American politicians were shaking their fists at the country’s leading tech companies. Republicans insisted that new media was as hopelessly biased against them as traditional media, and they demanded action. Democrats warned that tech giants like Amazon, Facebook, Apple, Alphabet, and Netflix had amassed too much market (and therefore political) power, that citizens had lost control of how these companies use the data they generate, and that the companies should therefore be broken into smaller, less dangerous pieces. European governments led a so-called techlash against the American tech powerhouses, which they accused of violating their customers’ privacy. COVID didn’t put an end to any of these criticisms, but it reminded policymakers and citizens alike just how indispensable digital technologies have become. Companies survived the pandemic only by allowing wired workers to log in from home. Consumers avoided possible infection by shopping online. Specially made drones helped deliver lifesaving medicine in rich and poor countries alike. Advances in telemedicine helped scientists and doctors understand and fight the virus. Artificial intelligence helped hospitals predict how many beds and ventilators they would need at any one time. A spike in Google searches using phrases that included specific symptoms helped health officials detect outbreaks in places where doctors and hospitals are few and far between. AI played a crucial role in vaccine development by absorbing all available medical literature to identify links between the genetic properties of the virus and the chemical composition and effects of existing drugs.

Society would have much to gain from decriminalization. On the immediate practical level, we would feel safer in our homes and on our streets and much less concerned about the danger of our cars being burgled. In cities like Vancouver such crimes are often committed for the sake of obtaining drug money. More significantly perhaps, by exorcising this menacing devil of our own creation, we would automatically give up a lot of unnecessary fear. We could all breathe more freely. Many addicts could work at productive jobs if the imperative of seeking illegal drugs did not keep them constantly on the street. It’s interesting to learn that before the War on Drugs mentality took hold in the early twentieth century, a prominent individual such as Dr. William Stewart Halsted, a pioneer of modern surgical practice, was an opiate addict for over forty years. During those decades he did stellar and innovative work at Johns Hopkins University, where he was one of the four founding physicians. He was the first, for example, to insist that members of his surgical team wear rubber gloves — a major advance in eradicating post-operative infections. Throughout his career, however, he never got by with less than 180 milligrams of morphine a day. “On this,” said his colleague, the world-renowned Canadian physician Sir William Osler, “he could do his work comfortably and maintain his excellent vigor.” As noted at the Common Sense for Drug Policy website: Halsted’s story is revealing not only because it shows that with a morphine addiction the proper maintenance dose can be productive. It also illustrates the incredible power of the drug in question. Here was a man with almost unlimited resources — moral, physical, financial, medical — who tried everything he could think of and he was hooked until the day he died. Today we would send a man like that to prison. Instead he became the father of modern surgery.

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Astonishment: these women’s military professions—medical assistant, sniper, machine gunner, commander of an antiaircraft gun, sapper—and now they are accountants, lab technicians, museum guides, teachers…Discrepancy of the roles—here and there. Their memories are as if not about themselves, but some other girls. Now they are surprised at themselves. Before my eyes history “humanizes” itself, becomes like ordinary life. Acquires a different lighting. I’ve happened upon extraordinary storytellers. There are pages in their lives that can rival the best pages of the classics. The person sees herself so clearly from above—from heaven, and from below—from the ground. Before her is the whole path—up and down—from angel to beast. Remembering is not a passionate or dispassionate retelling of a reality that is no more, but a new birth of the past, when time goes in reverse. Above all it is creativity. As they narrate, people create, they “write” their life. Sometimes they also “write up” or “rewrite.” Here you have to be vigilant. On your guard. At the same time pain melts and destroys any falsehood. The temperature is too high! Simple people—nurses, cooks, laundresses—behave more sincerely, I became convinced of that…They, how shall I put it exactly, draw the words out of themselves and not from newspapers and books they have read—not from others. But only from their own sufferings and experiences. The feelings and language of educated people, strange as it may be, are often more subject to the working of time. Its general encrypting. They are infected by secondary knowledge. By myths. Often I have to go for a long time, by various roundabout ways, in order to hear a story of a “woman’s,” not a “man’s” war: not about how we retreated, how we advanced, at which sector of the front…It takes not one meeting, but many sessions. Like a persistent portrait painter. I sit for a long time, sometimes a whole day, in an unknown house or apartment. We drink tea, try on the recently bought blouses, discuss hairstyles and recipes. Look at photos of the grandchildren together. And then…After a certain time, you never know when or why, suddenly comes this long-awaited moment, when the person departs from the canon—plaster and reinforced concrete, like our monuments—and goes on to herself. Into herself. Begins to remember not the war but her youth. A piece of her life…I must seize that moment. Not miss it! But often, after a long day, filled with words, facts, tears, only one phrase remains in my memory (but what a phrase!): “I was so young when I left for the front, I even grew during the war.” I keep it in my notebook, although I have dozens of yards of tape in my tape recorder. Four or five cassettes… What helps me? That we are used to living together. Communally. We are communal people. With us everything is in common—both happiness and tears. We know how to suffer and how to tell about our suffering. Suffering justifies our hard and ungainly life.

REPROGRAMMING MY BIOCHEMISTRY A common attitude is that taking substances other than food, such as supplements and medications, should be a last resort, something one takes only to address overt problems. Terry and I believe strongly that this is a bad strategy, particularly as one approaches middle age and beyond. Our philosophy is to embrace the unique opportunity we have at this time and place to expand our longevity and human potential. In keeping with this health philosophy, I am very active in reprogramming my biochemistry. Overall, I am quite satisfied with the dozens of blood levels I routinely test. My biochemical profile has steadily improved during the years that I have done this. For boosting antioxidant levels and for general health, I take a comprehensive vitamin-and-mineral combination, alpha lipoic acid, coenzyme Q10, grapeseed extract, resveratrol, bilberry extract, lycopene, silymarin (milk thistle), conjugated linoleic acid, lecithin, evening primrose oil (omega-6 essential fatty acids), n-acetyl-cysteine, ginger, garlic, l-carnitine, pyridoxal-5-phosphate, and echinacea. I also take Chinese herbs prescribed by Dr. Glenn Rothfeld. For reducing insulin resistance and overcoming my type 2 diabetes, I take chromium, metformin (a powerful anti-aging medication that decreases insulin resistance and which we recommend everyone over 50 consider taking), and gymnema sylvestra. To improve LDL and HDL cholesterol levels, I take policosanol, gugulipid, plant sterols, niacin, oat bran, grapefruit powder, psyllium, lecithin, and Lipitor. To improve blood vessel health, I take arginine, trimethylglycine, and choline. To decrease blood viscosity, I take a daily baby aspirin and lumbrokinase, a natural anti-fibrinolytic agent. Although my CRP (the screening test for inflammation in the body) is very low, I reduce inflammation by taking EPA/DHA (omega-3 essential fatty acids) and curcumin. I have dramatically reduced my homocysteine level by taking folic acid, B6, and trimethylglycine (TMG), and intrinsic factor to improve methylation. I have a B12 shot once a week and take a daily B12 sublingual. Several of my intravenous therapies improve my body’s detoxification: weekly EDTA (for chelating heavy metals, a major source of aging) and monthly DMPS (to chelate mercury). I also take n-acetyl-l-carnitine orally. I take weekly intravenous vitamins and alpha lipoic acid to boost antioxidants. I do a weekly glutathione IV to boost liver health. Perhaps the most important intravenous therapy I do is a weekly phosphatidylcholine (PtC) IV, which rejuvenates all of the body’s tissues by restoring youthful cell membranes. I also take PtC orally each day, and I supplement my hormone levels with DHEA and testosterone. I take I-3-C (indole-3-carbinol), chrysin, nettle, ginger, and herbs to reduce conversion of testosterone into estrogen. I take a saw palmetto complex for prostate health. For stress management, I take l-theonine (the calming substance in green tea), beta sitosterol, phosphatidylserine, and green tea supplements, in addition to drinking 8 to 10 cups of green tea itself. At bedtime, to aid with sleep, I take GABA (a gentle, calming neuro-transmitter) and sublingual melatonin. For brain health, I take acetyl-l-carnitine, vinpocetine, phosphatidylserine, ginkgo biloba, glycerylphosphorylcholine, nextrutine, and quercetin. For eye health, I take lutein and bilberry extract. For skin health, I use an antioxidant skin cream on my face, neck, and hands each day. For digestive health, I take betaine HCL, pepsin, gentian root, peppermint, acidophilus bifodobacter, fructooligosaccharides, fish proteins, l-glutamine, and n-acetyl-d-glucosamine. To inhibit the creation of advanced glycosylated end products (AGEs), a key aging process, I take n-acetyl-carnitine, carnosine, alpha lipoic acid, and quercetin. MAINTAINING A POSITIVE “HEALTH SLOPE” Most important,

Happiness in a tablet. This is our world. Prozac. Paxil. Xanax. Billions are spent to advertise such drugs. And billions more are spent purchasing them. You don’t even need a specific trauma; just “general depression” or “anxiety,” as if sadness were as treatable as the common cold. I knew depression was real, and in many cases required medical attention. I also knew we overused the word. Much of what we called “depression” was really dissatisfaction, a result of setting a bar impossibly high or expecting treasures that we weren’t willing to work for. I knew people whose unbearable source of misery was their weight, their baldness, their lack of advancement in a workplace, or their inability to find the perfect mate, even if they themselves did not behave like one. To these people, unhappiness was a condition, an intolerable state of affairs. If pills could help, pills were taken. But pills were not going to change the fundamental problem in the construction. Wanting what you can’t have. Looking for self-worth in the mirror. Layering work on top of work and still wondering why you weren’t satisfied—before working some more. I knew. I had done all that. There was a stretch where I could not have worked more hours in the day without eliminating sleep altogether. I piled on accomplishments. I made money. I earned accolades. And the longer I went at it, the emptier I began to feel, like pumping air faster and faster into a torn tire.

In 1980, Stanford University internist and epidemiologist James Fries recognized that modern medicine was not extending the human lifespan, and yet survival curves were changing. More people were living vitally until eighty-five or ninety, and then dying quickly, like the wonderful one-hoss shay in Oliver Wendell Holmes’s poem, which ran perfectly for a hundred years and then fell apart all at once.2 Fries called this phenomenon “compression of morbidity.”3 In 1900, because most deaths were premature, the human survival “curve” was a diagonal line; now it is more of a rectangle—especially if you have no risk factors (Figure 7.1). In 2040 there will be ten times as many eighty-five-year-olds as there were in 1990. This is not because the normal human lifespan is any longer than it was, but because fewer people will die before eighty. After eighty the lifespan will reflect little increase. Medical advances like antibiotics, new cancer treatments, and kidney transplants all serve to decrease premature death. But they do not alter the fact that the bodies of most of us, like the one-hoss shay, have not evolved to live past one hundred.

Eric Spiegel, the head of Siemens’ US arm, laid out a vision not that far removed from Ms Huang’s when he spoke at a breakfast in Washington hosted by the McKinsey Global Institute, the consultancy’s think-tank. The German engineering company, he said, would soon begin delivering spare parts to customers via email and 3D printers, also avoiding physical borders and the usual logistical complexities of global trade. But the advances in business are also coming up against fundamental debates about privacy. The Edward Snowden revelations of US online snooping have sparked a worldwide debate about privacy and the internet. Receiving less attention is the way international trade negotiations are trying to deal with what limits, if any, ought to be set on the flow of data around the globe and how to prepare for a digital future that is already a reality in some sectors. The negotiation of a 12-country Transpacific trade partnership (TPP) has sparked debate in Australia and New Zealand over whether companies ought to be allowed to store personal banking and medical data in foreign countries, or if such sensitive information should even be allowed to cross borders freely.