Lab Quality Quotes

Every time we witness an injustice and do not act, we train our character to be passive in its presence and thereby eventually lose all ability to defend ourselves and those we love. In a modern economy it is impossible to seal oneself off from injustice. If we have brains or courage, then we are blessed and called on not to frit these qualities away, standing agape at the ideas of others, winning pissing contests, improving the efficiencies of the neocorporate state, or immersing ourselves in obscuranta, but rather to prove the vigor of our talents against the strongest opponents of love we can find. If we can only live once, then let it be a daring adventure that draws on all our powers. Let it be with similar types whos hearts and heads we may be proud of. Let our grandchildren delight to find the start of our stories in their ears but the endings all around in their wandering eyes. The whole universe or the structure that perceives it is a worthy opponent, but try as I may I can not escape the sound of suffering. Perhaps as an old man I will take great comfort in pottering around in a lab and gently talking to students in the summer evening and will accept suffering with insouciance. But not now; men in their prime, if they have convictions are tasked to act on them.

Aloysius Blatt. With his library of science books, table full of lab-quality experiments, extensive collection of academic medals, and graduate-level vocabulary,

The commercialization of molecular biology is the most stunning ethical event in the history of science, and it has happened with astonishing speed. For four hundred years since Galileo, science has always proceeded as a free and open inquiry into the workings of nature. Scientists have always ignored national boundaries, holding themselves above the transitory concerns of politics and even wars. Scientists have always rebelled against secrecy in research, and have even frowned on the idea of patenting their discoveries, seeing themselves as working to the benefit of all mankind. And for many generations, the discoveries of scientists did indeed have a peculiarly selfless quality... Suddenly it seemed as if everyone wanted to become rich. New companies were announced almost weekly, and scientists flocked to exploit genetic research... It is necessary to emphasize how significant this shift in attitude actually was. In the past, pure scientists took a snobbish view of business. They saw the pursuit of money as intellectually uninteresting, suited only to shopkeepers. And to do research for industry, even at the prestigious Bell or IBM labs, was only for those who couldn't get a university appointment. Thus the attitude of pure scientists was fundamentally critical toward the work of applied scientists, and to industry in general. Their long-standing antagonism kept university scientists free of contaminating industry ties, and whenever debate arose about technological matters, disinterested scientists were available to discuss the issues at the highest levels. But that is no longer true. There are very few molecular biologists and very few research institutions without commercial affiliations. The old days are gone. Genetic research continues, at a more furious pace than ever. But it is done in secret, and in haste, and for profit.

Csikszentmihalyi teamed up with two other leading psychologists—Howard Gardner at Harvard, and William Damon at Stanford—to study these changes, and to see why some professions seemed healthy while others were growing sick. Picking the fields of genetics and journalism as case studies, they conducted dozens of interviews with people in each field. Their conclusion32 is as profound as it is simple: It’s a matter of alignment. When doing good (doing high-quality work that produces something of use to others) matches up with doing well (achieving wealth and professional advancement), a field is healthy. Genetics, for example, is a healthy field because all parties involved respect and reward the very best science. Even though pharmaceutical companies and market forces were beginning to inject vast amounts of money into university research labs in the 1990s, the scientists whom Csikszentmihalyi, Gardner, and Damon interviewed did not believe they were being asked to lower their standards, cheat, lie, or sell their souls. Geneticists believed that their field was in a golden age in which excellent work brought great benefits to the general public, the pharmaceutical companies, the universities, and the scientists themselves.

This banal and crass process is how I met Lindsay Mills, my partner and the love of my life. Looking at the photos now, I’m amused to find that nineteen-year-old Lindsay was gawky, awkward, and endearingly shy. To me at the time, though, she was a smoldering blonde, absolutely volcanic. What’s more, the photos themselves were beautiful: they had a serious artistic quality, self-portraits more than selfies. They caught the eye and held it. They played coyly with light and shade. They even had a hint of meta fun: there was one taken inside the photo lab where she worked, and another where she wasn’t even facing the camera.

A century ago, Albert Einstein revolutionised our understanding of space, time, energy and matter. We are still finding awesome confirmations of his predictions, like the gravitational waves observed in 2016 by the LIGO experiment. When I think about ingenuity, Einstein springs to mind. Where did his ingenious ideas come from? A blend of qualities, perhaps: intuition, originality, brilliance. Einstein had the ability to look beyond the surface to reveal the underlying structure. He was undaunted by common sense, the idea that things must be the way they seemed. He had the courage to pursue ideas that seemed absurd to others. And this set him free to be ingenious, a genius of his time and every other. A key element for Einstein was imagination. Many of his discoveries came from his ability to reimagine the universe through thought experiments. At the age of sixteen, when he visualised riding on a beam of light, he realised that from this vantage light would appear as a frozen wave. That image ultimately led to the theory of special relativity. One hundred years later, physicists know far more about the universe than Einstein did. Now we have greater tools for discovery, such as particle accelerators, supercomputers, space telescopes and experiments such as the LIGO lab’s work on gravitational waves. Yet imagination remains our most powerful attribute. With it, we can roam anywhere in space and time. We can witness nature’s most exotic phenomena while driving in a car, snoozing in bed or pretending to listen to someone boring at a party.

The octopus, although an invertebrate—with no thalamus or cortex to speak of—behaves in ways that utterly belie its primitive label. It has around 500 million neurons, not too far from the numbers in a cat. But the octopus brain is decidedly unusual, with an exceptionally parallel architecture—almost always a positive quality when you are talking about brains. The majority of octopus neurons are to be found not in its brain, but in its arms. In effect, if you include the neuronal bundles in its limbs, the octopus has nine semi-independent brains, making it unique in the animal kingdom. The octopus is also a genius among ocean creatures. It has highly developed memory and attentional systems. In nature, this allows these invertebrates to take on a wide range of shapes to mimic other animals, rocks, or even plants. In the lab, octopuses can distinguish shapes and colors, navigate through a maze, open a jar with a screw-on lid, and even learn by observing the behavior of another octopus—an ability thought previously only to exist in highly social animals.

The following month, before word of the French success reached America, Franklin came up with his own ingenious way to conduct the experiment, according to accounts later written by himself and his friend the scientist Joseph Priestley. He had been waiting for the steeple of Philadelphia’s Christ Church to be finished, so he could use its high vantage point. Impatient, he struck on the idea of using instead a kite, a toy he had enjoyed flying and experimenting with since his boyhood days in Boston. To do the experiment in some secrecy, he enlisted his son, William, to help fly the silk kite. A sharp wire protruded from its top and a key was attached near the base of the wet string, so that a wire could be brought near it in an effort to draw sparks. Clouds passed over to no effect. Franklin began to despair when he suddenly saw some of the strands of the string stiffen. Putting his knuckle to the key, he was able to draw sparks (and, notably, to survive). He proceeded to collect some of the charge in a Leyden jar and found it had the same qualities as electricity produced in a lab. “Thereby the sameness of electrical matter with that of lightning,” he reported in a letter the following October, was “completely demonstrated.

Nothing in the period that followed was too good for the Rouge; it had the best blast furnaces, the best machine tools, the best metal labs, the best electrical systems, the most efficient efficiency experts. At its maturity in the mid-twenties, the Rouge dwarfed all other industrial complexes. It was a mile and a half long and three quarters of a mile wide. Its eleven hundred acres contained ninety-three buildings, twenty-three of them major. There were ninety-three miles of railroad track on it and twenty-seven miles of conveyor belts. Some seventy-five thousand men worked there, five thousand of them doing nothing but keeping it clean, using eighty-six tons of soap and wearing out five thousand mops each month. By the standards of the day the Rouge was, in fact, clean and quiet. Little was wasted. A British historian of the time, J. A. Spender, wrote of its systems: “If absolute completeness and perfect adaptation of means to end justify the word, they are in their own way works of art.” Dissatisfied with the supply and quality of the steel he was getting from the steel companies, Ford asked how much it would cost to build a steel plant within the Rouge. About $35 million, Sorensen told him. “What are you waiting for?” said Ford. Equally dissatisfied with both the availability and the quality of glass, he built a glass factory at the Rouge as well. The

To Aristotle, eudaimonia is not a fleeting positive emotion. Rather, it is something you do. Leading a eudaimonic life, Aristotle argued, requires cultivating the best qualities within you both morally and intellectually and living up to your potential. It is an active life, a life in which you do your job and contribute to society, a life in which you are involved in your community, a life, above all, in which you realize your potential, rather than squander your talents. Psychologists have picked up on Aristotle’s distinction. If hedonia is defined as “feeling good,” they argue, then eudaimonia is defined as “being and doing good”—and as “seeking to use and develop the best in oneself” in a way that fits with “one’s deeper principles.” It is a life of good character. And it pays dividends. As three scholars put it, “The more directly one aims to maximize pleasure and avoid pain, the more likely one is to produce instead a life bereft of depth, meaning, and community.” But those who choose to pursue meaning ultimately live fuller—and happier—lives. It’s difficult, of course, to measure a concept like meaning in the lab, but, according to psychologists, when people say that their lives have meaning, it’s because three conditions have been satisfied: they evaluate their lives as significant and worthwhile—as part of something bigger; they believe their lives make sense; and they feel their lives are driven by a sense of purpose.

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Virtually all the insulin now taken by diabetics is produced by genetically altered bacteria in a lab.6 Before that it had to be extracted from the pancreases of cows and pigs—a process that was both expensive and lacking in quality control. As

What qualities are essentials for this type of dog? It takes focus, endurance, an ability to scent discriminate, and, some would say excessive drive. For me, Black Labs of working/field trail lines have proven to be very capable in this role. However, I know that many breeds of dogs would work just as well. It takes a dog that is tireless, with a boundless desire to please. The dog must be tough enough for the weather and terrain and just dumb enough to want to do this more than anything else in the world. – Deb Tirmenstein

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The other was Atul Gawande , a surgical resident who I had gotten to know during his year at the Harvard School of Public Health . Atul later developed the surgical checklist for WHO and created Ariadne Labs, an influential collaboration of innovators, implementers, and healthcare leaders focused on quality and safety.

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The Core Debugging Process The core of the debugging process consists of four steps: Reproduce: Find a way to reliably and conveniently reproduce the problem on demand. Report erratum Prepared exclusively for castLabs GmbH this copy is (P2.0 printing, February 2010) FIRST THINGS FIRST 18 Diagnose: Construct hypotheses, and test them by performing experiments until you are confident that you have identified the underlying cause of the bug. Fix: Design and implement changes that fix the problem, avoid intro- ducing regressions, and maintain or improve the overall quality of the software. Reflect: Learn the lessons of the bug. Where did things go wrong? Are there any other examples of the same problem that will also need fixing? What can you do to ensure that the same problem doesn’t happen again?

Most software is designed for the development lab or the testers in the Quality Assurance (QA) department.

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I am a smart guy. I recycle. Once I found a lost cat and took it to a shelter. Sometimes I make jokes. If there’s something wrong with your car, I can tell what by listening to it. I like kids, except the ones who are rude to adults and the parents just stand there, smiling. I have a job. I own my apartment. I rarely lie. These are qualities I keep hearing people are looking for. I can only think there must be something else, something no one mentions, because I have no friends, am estranged from my family, and haven’t dated in this decade. There is a guy in Lab Control who killed a woman with his car, and he gets invited to parties. I don’t understand that.

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Several weeks of the elimination/provocation diet in conjunction with a high-quality detoxification powder clears up common digestive complaints such as gas, bloating, diarrhea, and constipation for many people. If a digestive problem still persists, I run a GI stool and salivary panel to see if parasites or other pathogens are causing problems. It’s not uncommon to find infections by an amoeba, Giardia, roundworms, candida yeast, excess bacteria, or other pathogens affecting the person’s gut health. How to eradicate these parasites and pathogens is beyond the scope of this book, and methods vary. There are situations in which I will recommend drugs instead of herbal remedies, because medications are ultimately more effective and easier on my patient. Herbal remedies, on the other hand, work well for many other conditions, including candida overgrowth271 and h.pylori bacteria.272

Undependable people, in contrast, provide erratically and inflict heavy costs on their mates. In a study of newlywed couples, my lab found that emotionally unstable men were especially costly to women. They tended to be self-centered, to monopolize shared resources, and to be possessive, monopolizing much of the time of their wives. These men showed higher-than-average sexual jealousy, becoming enraged when their wives even talked with someone else, as well as dependency: they would insist that their mates provide for all of their needs. With a tendency to being abusive, both verbally and physically, they also displayed inconsiderateness, such as by failing to show up on time. Emotionally unstable men were also moodier than their more stable counterparts, sometimes crying after minor setbacks. Suggesting a further diversion of their time and resources was their tendency to have more affairs than average.34 All of these costs indicate that emotionally unstable mates will absorb their partner’s time and resources, divert their own time and resources elsewhere, and fail to channel resources consistently over time. Dependability and stability are personal qualities that signal increased likelihood that a woman’s resources will not be drained by the man.

We have been a conservative and non-competitive organization. We engineer for high quality service, with long life, low maintenance costs, [and a] high factor of reliability as basic elements in our philosophy of design and manufacture. But our basic technology is becoming increasingly similar to that of a high volume, annual model, highly competitive, young, vigorous and growing industry.”32 In other words, there would soon be a revolution in electronics. And as he saw it, Bell Labs would need to lead it rather than join it. Kelly wanted his old team back—the team he had handpicked in the late 1930s.

I’m here to do the ‘Taste Test’ . . . . . . I’m going to need a sample of every type of Cookie in your house. Then I’ll take them back to our Government Labs for testing and send your results in the post. By the way, the ‘Poor Cookie Quality Fine’ is $1,000. Good luck!

Think of every hospital in the U.S. that uses Nuance. Think about how many days it was down, multiplied by the number of lab results, transfers, discharges, and how many of those are time sensitive,” Corman said. “In some cases, time matters. Pain level is affected. Quality of life is affected. Mortality is affected.

As John Pierce later explained, “The laser is to ordinary light as a broadcast signal is to static.” Ordinary light radiates in a chaotic and scattershot manner. The laser does not. From the perspective of a communications engineer, it is coherent—meaning it is intense and ordered and nearly all one frequency, which are important qualities for carrying information. “In principle it makes it possible to do everything with light that one does with radio waves,” Pierce added. What’s more, the great advantage is that the “bandwidth” of such light—which is related to its capacity—“is hundreds or thousands of times greater than we now have.” The very title of the Townes and Schawlow patent suggested a clear direction.9 Bell Labs’ claim for the laser was that it was a new method for communication.

That perceived natural monopoly wasn’t only justified by the phone system’s technological complexity and interdependence; it was also—in an argument that telephone executives made over and over again—a matter of economics. With one company in effect serving the country’s phone customers, some parts of the phone business that were highly profitable, such as long-distance service, could subsidize other aspects that were less profitable, such as local calling. Profits from high-paying corporate customers, moreover, could subsidize service to residential customers. Profits from dense urban areas could subsidize expansion into sparse rural areas. All in all, this kind of “averaging,” as it was sometimes called, helped make telephone service available and affordable for most Americans. At the same time, thanks to technological innovations, the quality of the service had steadily improved over the years, even as many of the costs had steadily decreased.

In a system that required supreme durability and quality, there were, in other words, two crucial elements that had neither: switching relays and vacuum tubes. As we’ve seen, tubes were extremely delicate and difficult to make; they required a lot of electricity and gave off great heat. Switches—the mechanisms by which each customer’s call was passed along the system’s vast grid to the precise party he was calling—were prone to similar problems. They were delicate mechanical devices; they used relays that employed numerous metal contacts; they could easily stop working and would eventually wear out.

So what was the Bell System waiting for? Kelly acknowledged that the phone company would capitalize on the transistor long after “other fields of application” such as the home entertainment industries.4 The recent Justice Department antitrust suit, which was now moving forward, was a stark reminder why: The phone company was a regulated monopoly and not a private company; it had no competitors pushing it to move forward faster. What’s more, it was obliged to balance costs against service quality in the most cautious way possible. “Everything that we design must go through the judgment of lots of people as to its ability to replace the old,” Kelly told an audience of phone executives in October 1951.

Likewise, in men a careful assessment of clinical symptoms, physical examination, lifestyle factors, and biochemical lab data are all necessary not only to determine if you are a candidate for HOT with true testosterone deficiency, but also to rule out any important red flags that would require a deeper investigation and may lead to alternative therapeutic options.

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Constructionism suggests a way forward, a method to engage with others. In this approach, the last thing I want to do is pin you down and inspect you, as if you were some lab sample. I will not reduce you to a type or restrict you to a label, like many of those human-typology systems do—Myers-Briggs, the Enneagram, the zodiac, and so on. Instead, I want to receive you as an active creator. I want to understand how you construct your point of view. I want to ask you how you see things. I want you to teach me about the enduring energies of old events that shape how you see the world today. I’m going to engage with you. Looking at a person is different from looking at a thing because a person is looking back at you. I’m going to get to know you at the same time you’re going to get to know me. Quality conversation is the essence of this approach.

DEA chemists looked into the matter and could find no connection to the Nazis. Some scientists believe that what Paillet actually dug up was the Birch reduction method, named after the Australian scientist Arthur Birch. Whatever the truth of the matter, the “Nazi” moniker stuck. Paillet gave five of his friends fishing tackle boxes containing materials and detailed instructions on how to make meth using this method, and from there, the recipe spread, and Nazi dope labs began sprouting up all across the Ozarks like toxic mushrooms. “I knew we were in a lot of trouble,” says John Cornille, “when the first sample of Nazi meth we sent to the lab turned out to be 92 percent pure methamphetamine, which meant it was quality dope.

There were outlaw bikers and meth labs close by. Berenson was readier to believe that. Stories about the badlands were legion. But a pained echo in a chance remark about Dean’s daughter led her to believe that the kid was in some way the problem. She was fourteen years old. Berenson put two and two together and made five. She figured maybe the kid was hanging with the bikers or experimenting with crystal and causing big problems at home. Then she revised her opinion. The quality problems up at Highland Park became common knowledge inside the company. Berenson knew that Dean had a difficult split responsibility. As a director of the corporation he had a fiduciary duty to see it do well. But he also had a parallel responsibility to the Pentagon to make sure New Age sold it only the good stuff. Berenson figured

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Many know that LSD, a synthetic molecule, was born in a laboratory in Switzerland and consumed for the first time by a chemist as he rode home on a bicycle. But fewer are aware of some of the more quirky traits of the family of chemicals that lysergic acid belongs to: the ‘ergot alkaloids’. All alkaloid drugs are interesting in their own way, but the ergot alkaloids are particularly curious. One: they are product of a parasite. Two: they have a saint. Three: they have ‘uterotonic’ qualities. Ergot alkaloids – including lab-born LSD – can induce contractions in the womb. LSD’s wild relatives have been employed to induce birth in delayed and difficult conditions (as well as abortions

talk a lot about a ketogenic diet in this book because of the miraculous health benefits it provides. This is a diet that helps shift your body’s metabolic engine from burning carbohydrates to burning fats. Interestingly, the cells of your body have the metabolic flexibility to adapt from using glucose for fuel to using ketones, which are a byproduct of breaking down fats. We will talk about this more in the cancer section of this book, but cancer cells do not have this metabolic flexibility to use fat as energy. They require glucose to thrive, which makes a ketogenic diet so effective for treating and preventing cancer.   A ketogenic diet calls for minimizing carbohydrates and replacing them with healthy fats and moderate amounts of high-quality protein. A ketogenic diet requires that roughly 50 to 70 percent of your food intake come from healthy fats, such as avocado, coconut oil, grass-fed butter, organic pasture raised eggs, and raw nuts. This diet will also help optimize your weight and prevent virtually all chronic degenerative diseases. Because you are minimizing carbs and replacing them with healthy fats, your body will shift from burning carbs as your primary fuel to burning fat.   Dr. Peter Attia, a Stanford University trained physician specializing in metabolic science, applied the ketogenic diet to his lifestyle to see what would happen. He essentially used himself as a lab rat and received incredible results. Although he was an active and fit guy, he always had a tendency toward metabolic syndrome. Metabolic syndrome is a cluster of conditions – increased blood pressure, high blood sugar, excess body fat around the waist, and abnormal cholesterol or triglyceride levels – that occur together, increasing your risk of heart disease, stroke, and diabetes. He decided to experiment with the ketogenic diet and see if it could improve his overall health status.

But the best way to know if you are actively losing bone is through lab tests that evaluate bone turnover.

But the best way to know if you are actively losing bone is through lab tests that evaluate bone turnover. Depending on your history and risk factors you may also need tests that can identify any secondary conditions (e.g., parathyroid disease, vitamin D deficiency, or kidney disease) that could result in bone loss (see Chapter 5).

Avengers Endgame done, Spider-Man Far From Home theory says Tony Stark made the spider that bit Peter Parker A new fan theory says that it will be revealed in the upcoming Marvel movie Spider-Man: Far From Home that Tony Stark created the spider that bit a teenage Peter Parker and gave him his superpowers. Tony died at the end of Avengers: Endgame, and shared a fatherly relationship with Peter in the Marvel Cinematic Universe. If this theory were to be proven true, it would give new meaning to their father-son relationship. It has previously been reported that Far From Home, a sequel to 2017’s Spider-Man: Homecoming, will reveal a major secret about Tony. A trailer revealed that Tony has left behind a secret lab for Peter. The theory, posted on Reddit, suggests that Tony worked with Norman Osborne to create the spider that bit Peter, which is why he knew his identity in Captain America: Civil War, and shared such a close bond with him. This will also allow Marvel to introduce Norman into the MCU. A fan had previously ‘leaked’ that Marvel is considering making Norman Osborne (who goes on to become the Green Goblin) a major new villain in the overarching story of the MCU. Another theory suggests that Tony was behind Uncle Ben’s death, which happens before we’re introduced to this version of Peter in the films. A version of this theory previously stated suggests that Uncle Ben died during the Battle of New York, which could indirectly mean that Tony was responsible for it. Far From Home is directed by Jon Watts, and stars Samuel L Jackson, Cobie Smulders and Jake Gyllenhaal in supporting roles, in addition to Tom Holland as Peter. The embargo on reviews will lift on Wednesday - two weeks ahead of release - which suggests that Marvel is positive about the quality of the film.

This is the former laboratory of Dr. Fritz Hauschild, head of pharmacology at Temmler from 1937 until 1941, who was in search of a new type of medicine, a “performance-enhancing drug.” This is the former drug lab of the Third Reich. Here, in porcelain crucibles attached to pipes and glass coolers, the chemists boiled up their flawless matter. Lids rattled on potbellied flasks, orange steam released with a sharp hiss while emulsions crackled and white-gloved fingers made adjustments. Here the methamphetamine produced was of a quality that even Walter White, the drug cook in the TV series Breaking Bad, which depicts meth as a symbol of our times, could only have dreamed of.

A scientific career proceeded along two parallel tracks, she wrote: real science and professional science. Real science was doing experiments, making discoveries, the work she’d fallen in love with back in the Watson lab, the long and winding conversations about science along Bungtown Road. “A unique kind of exhilaration and excitement,” as she described it. “What is known is useful and sometimes beautiful, but only what is unknown is of interest. It is this open-minded quality of science—the excitement of the search, the constant, but usually unsatisfied, striving toward the solution of some very difficult problem—that is addictive.” Professional science was figuring out how to get paid for making discoveries: writing grants to buy equipment and pay grad students and postdocs, publishing papers and speaking at scientific conferences to get “exposure” in the field, winning tenure, teaching, managing a lab. It was a job “constructed by and for men (a certain type of man),” she wrote. Someone with a wife at home to manage life outside the lab, and with supreme self-confidence. Real science and professional science were each a full-time job, with intense pressures and long hours.