John Ioannidis Quotes

John P. Ioannidis published a controversial paper titled “Why Most Published Research Findings Are False.”39 The paper studied positive findings documented in peer-reviewed journals: descriptions of successful predictions of medical hypotheses carried out in laboratory experiments. It concluded that most of these findings were likely to fail when applied in the real world. Bayer Laboratories recently confirmed Ioannidis’s hypothesis. They could not replicate about two-thirds of the positive findings claimed in medical journals when they attempted the experiments themselves.40

The biggest problem is that the vast majority of studies are not experimental, randomized designs. Simply by observing what people eat—or even worse, what they recall they ate—and trying to link this to disease outcomes is moreover a waste of effort. These studies need to be largely abandoned. We’ve wasted enough resources and caused enough confusion.” —Professor John Ioannidis, MD, 2018

For all of these reasons, a shocking amount of expert research turns out to be wrong. John Ioannidis, a Greek doctor and epidemiologist, examined forty-nine studies published in three prominent medical journals.8 Each study had been cited in the medical literature at least a thousand times. Yet roughly one-third of the research was subsequently refuted by later work. (For example, some of the studies he examined promoted estrogen replacement therapy.) Dr. Ioannidis estimates that roughly half of the scientific papers published will eventually turn out to be wrong.9 His research was published in the Journal of the American Medical Association, one of the journals in which the articles he studied had appeared. This does create a certain mind-bending irony: If Dr. Ioannidis’s research is correct, then there is a good chance that his research is wrong.

For all of these reasons, a shocking amount of expert research turns out to be wrong. John Ioannidis, a Greek doctor and epidemiologist, examined forty-nine studies published in three prominent medical journals.8 Each study had been cited in the medical literature at least a thousand times. Yet roughly one-third of the research was subsequently refuted by later work. (For example, some of the studies he examined promoted estrogen replacement therapy.) Dr. Ioannidis estimates that roughly half of the scientific papers published will eventually turn out to be wrong.9 His research was published in the Journal of the American Medical Association, one of the journals in which the articles he studied had appeared. This does create a certain mind-bending irony: If Dr. Ioannidis’s research is correct, then there is a good chance that his research is wrong. Regression

Concerned by the disavowal of such studies, experts spoke up. “For some applications, race may continue to be the best variable to capture the influence on health,” wrote John P. A. Ioannidis, Neil R. Powe, and Clyde Yancy in the Journal of the American Medical Association in 2021. “Quick dismissal,” they cautioned, “may worsen outcomes, especially for the most disadvantaged populations.