Insulin Quotes

My books are my staple diet. As serious as insulin doses for those who are diabetics!

We'll act as if all this were a bad dream." A bad dream. To the person in the bell jar, blank and stopped as a dead baby, the world itself is the bad dream. A bad dream. I remembered everything. I remembered the cadavers and Doreen and the story of the fig tree and Marco's diamond and the sailor on the Common and Doctor Gordon's wall-eyed nurse and the broken thermometers and the Negro with his two kinds of beans and the twenty pounds I gained on insulin and the rock that bulged between sky and sea like a gray skull. Maybe forgetfulness, like a kind snow, would numb and cover them. But they were part of me. They were my landscape.

I needed cutting now the way a diabetic needs insulin. It was a bulwark, steady and unyielding, I could throw up against the insidious, corrosive lapping of a whispering sea of uneasiness.

What is Insulin? Insulin is a hormone that allows the glucose (also called blood sugar) in your blood to get out of your bloodstream and into your cells for energy for whatever your current activity or inactivity is. If you have more glucose in your bloodstream than your current energy need, the excess is stored in your liver (called glycogen in its storage form). If your liver is full and you still have excess glucose in your bloodstream, the rest is stored as body fat around your butt, thighs, belly—and generally every place you don’t want it to be. 

Simon whispered to me, “But is everything okay?” “No,” Tori said. “I kidnapped her and forced her to escape with me. I’ve been using her as a human shield against those guys with guns, and I was just about to strangle her and leave her body here to throw them off my trail. But then you showed up and foiled my evil plans. Lucky for you, though. You get to rescue poor little Chloe again and win her undying gratitude.” “Undying gratitude?” Simon looked at me. “Cool. Does that come with eternal servitude? If so, I like my eggs sunnyside up.” I smiled. “I’ll remember that.” *** “Oh, right. You must be starving.” Simon reached into his pockets. “I can offer one bruised apple and one brown banana. Convenience stores aren’t the place to buy fruit, as I keep telling someone.” “Better than these. For you, anyway, Simon.” Derek passed a bar to Tori. “Because you aren’t supposed to have those, are you?” I said. “Which reminds me…” I took out the insulin. “Derek said it’s your backup.” “So my dark secret is out.” “I didn’t know it was a secret.” “Not really. Just not something I advertise.” ... “Backup?” Tori said. “You mean he didn’t need that?” “Apparently not,” I murmured. Simon looked from her to me, confused, then understanding. “You guys thought…” “That if you didn’t get your medicine in the next twenty-four hours, you’d be dead?” I said. “Not exactly, but close. You know, the old ‘upping the ante with a fatal disease that needs medication’ twist. Apparently, it still works.” “Kind of a letdown, then, huh?” “No kidding. Here we were, expecting to find you minutes from death. Look at you, not even gasping.” “All right, then. Emergency medical situation, take two.” He leaped to his feet, staggered, keeled over, then lifted his head weakly. “Chloe? Is that you?” He coughed. “Do you have my insulin?” I placed it in his outstretched hand. “You saved my life,” he said. “How can I ever repay you?” “Undying servitude sounds good. I like my eggs scrambled.” He held up a piece of fruit. “Would you settle for a bruised apple?” I laughed.

Organic Oreos are not a health food. When Coca-Cola begins selling organic Coke, as it surely will, the company will have struck a blow for the environment perhaps, but not for our health. Most consumers automatically assume that the word "organic" is synomymous with health, but it makes no difference to your insulin metabolism if the high-fructose corn syrup in your soda is organic.

How do you control the amount of insulin your body produces?  You control the amount of glucose you put into your bloodstream. Put in less glucose, your body will produce less insulin, and you will lose weight. Put in more glucose, your body will produce more insulin, and you will gain weight. That brings us to the premise of this book: Control your blood glucose, and you control your weight.    Lower blood glucose, and you will lose weight. This is universal.  How do you lower your blood glucose? The answers are in Glucose Control Eating©.

How We Gain and Lose Weight To understand how we gain and lose weight, we need to start with insulin. Medical researchers and internal medicine doctors almost universally agree that the amount of insulin a person produces determines weight gain and weight loss. For example, Gary Taubes, a medical researcher and recipient of multiple awards from the National Association of Science Writers, refers to insulin as “the stop-and-go light of weight gain and loss.”    Produce more insulin—you will gain weight. Produce less insulin— you will lose weight.

The Premise of Glucose Control Eating© You control the amount of glucose you put into your bloodstream. Put in less glucose, your body will produce less insulin, and you will lose weight. Put in more glucose, your body will produce more insulin, and you will gain weight. That brings us to the premise of this book.   Control your glucose, and you control your weight.   How do you control your glucose and your weight?    How can you know which foods create lots of glucose and weight gain and which create less glucose and weight loss?   In the book, Glucose Control Eating©, I will not only tell you, but I will also show you, based on over 85,000 blood glucose tests, how much glucose different foods will create in your body.

That if you didnt get your medicine in the next twenty-four hours you'd be dead?" i said, " Not exactly, but close. you know, the old ' upping the ante with a fatal disease that needs medication twist. APerently it still works." "Kind of a letdown, then, huh?" "No kidding. Look at you, your not even gasping." " All right then, emergency medical situation, take two." he leaped to his feet, stagored, kneeled over, then lifted his head weakly. Chloe? Is that you?" he couphed, " DO you have my insulin?" i placed it in his outstreched hand. "You savedmy life, how can i ever repay you?" he said. "undying servitude sounds good. i like my eggs scrambled." he held up a piece of fruit, "Would you settle for a bruised apple?" i lauphed. "YOu guys are wierd." tori said. simon sat on the crate beside me. "thats right. we are totally wierd and completely uncool. you popularity is plummeting just by being near us. so why dont you-" "Chloe?" derek inturupted. "Hows your arm?" "HEr-?" simon swore under his breath. "Way to keep showing me up. first food. now her arm" he turned to me"How is it?

Insulin is not a cure for diabetes; it is a treatment. It enables the diabetic to burn sufficient carbohydrates, so that proteins and fats may be added to the diet in sufficient quantities to provide energy for the economic burdens of life.

Once we understand that obesity is a hormonal imbalance, we can begin to treat it. If we believe that excess calories cause obesity, then the treatment is to reduce calories. But this method has been a complete failure. However, if too much insulin causes obesity, then it becomes clear we need to lower insulin levels.

All right, then. Emergency medical situation, take two.” He leaped to his feet, staggered, keeled over, then lifted his head weakly. “Chloe? Is that you?” He coughed. “Do you have my insulin?” I placed it in his outstretched hand. “You saved my life,” he said. “How can I ever repay you?” “Undying servitude sounds good. I like my eggs scrambled.” He held up a piece of fruit. “Would you settle for a bruised apple?” I laughed.

Three times a day Petrovich showed up at the nurse’s office for his injections, always using the hypodermic needle himself like the most craven of junkies, though after shooting up he would play the concert piano in the auditorium with astounding artistry, as though insulin were the elixir of genius.

A recent study suggests that 75 per cent of the weight-loss response in obesity is predicted by insulin levels. Not willpower. Not caloric intake. Not peer support or peer pressure. Not exercise. Just insulin.

A bad dream. To the person in the bell jar, blank and stopped as a dead baby, the world itself is the bad dream. A bad dream. I remembered everything. I remembered the cadavers and Doreen and the story of the fig-tree and Marco's diamond and the sailor on the Common and Doctor Gordon's wall-eyed nurse and the broken thermometers and the negro with his two kinds of beans and the twenty pounds I gained on insulin and the rock that bulged between sky and sea like a grey skull. Maybe forgetfulness, like a kind snow, should numb and cover them. But they were part of me. They were my landscape

Hi Maggie, it's nice to see you again,' he said, smiling so sweetly I thought I might need insulin.

To the person in the bell jar, blank and stopped as a dead baby, the world itself is the bad dream. A bad dream. I remembered everything. I remembered the cadavers and Doreen and the story of the fig tree and Marco's diamond and the sailor on the Common and Doctor Gordon's wall-eyed nurse and the broken thermometer and the Negro with his two kinds of beans and the twenty pounds I gained on insulin and the rock that bulged between sky and sea like a gray skull. Maybe forgetfulness, like a kind snow, should numb and cover them. But they were a part of me. They were my landscape.

The key to the proper treatment of type 2 diabetes is to get rid of the excess sugar, not just move it around the body. The problem is both too much glucose and too much insulin.

All diets that result in weight loss do so on one basis and one basis only: They reduce circulating levels of insulin; they create and prolong the negative stimulus of insulin deficiency.

The healthy snack is one of the greatest weight-loss deceptions. The myth that ‘grazing is healthy’ has attained legendary status. If we were meant to ‘graze,’ we would be cows. Grazing is the direct opposite of virtually all food traditions. Even as recently as the 1960s, most people still ate just three meals per day. Constant stimulation of insulin eventually leads to insulin resistance. (For

...smiled so sweetly at Liam, I feared the poor sap might need insulin.

An overdose of insulin would be the easiest, cleanest route—especially since he keeps his meter and pens in the top right drawer of his desk, unprotected.

The root cause of the hyperglycemia in type 2 diabetes is high insulin resistance.

Carbohydrates trigger insulin release from the pancreas, causing growth of visceral fat; visceral fat causes insulin resistance and inflammation. High blood sugars, triglycerides, and fatty acids damage the pancreas. After years of overwork, the pancreas succumbs to the thrashing it has taken from glucotoxicity, lipotoxicity, and inflammation, essentially “burning out,” leaving a deficiency of insulin and an increase in blood glucose—diabetes.

The most fattening foods are the ones that have the greatest effect on our blood sugar and insulin levels.

Backup?" Tori said. "You mean he didn't need that?" "Apparently not," I murmured. Simon looked from her to me, confused, then understanding. "You guys thought..." "That if you didn't get your medicine in the next twenty-four hours, you'd be dead?" I said. "Not exactly, but close. You know, the old 'upping the ante with a fatal disease that needs medication' twist. Apparently, it still works." "Kind of a letdown, then, huh?" "No kidding. Here we were, expecting to find you minutes from death. Look at you, not even gasping." "All right, then. Emergency medical situation, take two." He leaped to his feet, staggered, keeled over, then lifted his head weakly. "Chloe? Is that you?" He coughed. "Do you have my insulin?" I placed it in his outstretched hand. "You saved my life," he said. "How can I ever repay you?" "Undying servitude sounds good. I like my eggs scrambled." He held up a piece of fruit. "Would you settle for a bruised apple?

He flipped her on her back and she squeaked. “I want to see you.” And he kissed her, tasting like darkest sin, like double chocolate without insulin, like pure malt whisky injected into her bloodstream.

Because consistently high insulin levels are the root cause of all the diseases of metabolic syndrome, it’s especially important for those with metabolic syndrome to consider how foods stimulate the release of insulin.

A drink consisting of a tablespoon of vinegar in a tall glass of water, drunk a few minutes before eating something sweet, flattens the ensuing glucose and insulin spikes. With that, cravings are curbed, hunger is tamed, and more fat is burned.

Like diabetes, she referred to it. Diabetics take insulin. In the same way, people with bipolar disorders took lithium, and alcoholics went to AA. Diabetes is the all-purpose analogy in my culture. Everybody has some form of it that needs to be tended on a maintenance basis. No one is ever cured, no one gets all the way well.

Carbohydrate-rich foods—grains, starchy vegetables, and sugars—work to keep insulin elevated in our circulation, and that traps the fat we eat in our fat cells and inhibits the use of that fat for fuel. That’s what the obesity research community should have been trying rigorously to resolve or refute for the past sixty years.

In other words, the science itself makes clear that hormones, enzymes, and growth factors regulate our fat tissue, just as they do everything else in the human body, and that we do not get fat because we overeat; we get fat because the carbohydrates in our diet make us fat. The science tells us that obesity is ultimately the result of a hormonal imbalance, not a caloric one—specifically, the stimulation of insulin secretion caused by eating easily digestible, carbohydrate-rich foods: refined carbohydrates, including flour and cereal grains, starchy vegetables such as potatoes, and sugars, like sucrose (table sugar) and high-fructose corn syrup. These carbohydrates literally make us fat, and by driving us to accumulate fat, they make us hungrier and they make us sedentary. This is the fundamental reality of why we fatten, and if we’re to get lean and stay lean we’ll have to understand and accept it, and, perhaps more important, our doctors are going to have to understand and acknowledge it, too.

if you eat the items of a meal containing starch, fibre, sugar, protein and fat in a specific order, you reduce your overall glucose spike by 73 per cent, as well as your insulin spike by 48 per cent. This is true for anyone, with or without diabetes. What is the right order? It’s fibre first, protein and fat second, starches and sugars last.

They were still trying when, all of a sudden, Charles Cullen simply went away. The problems with the insulin spikes disappeared with him.

Casket wreath* 13 Diabetes Insulin Leeches* 14 Hatchet embedded in skull Removal of hatchet, treatment of wound Larger

It was chemistry, not magic. No elevated C-peptide meant that the insulin wasn’t human.

Obesity is a hormonal disorder of fat regulation. Insulin is the major hormone that drives weight gain, so the rational therapy is to lower insulin levels.

All the conditions we thought were problems—obesity, insulin resistance, and beta cell dysfunction—are actually the body’s solutions to a single root cause—too much sugar.

With insulin, the stone was rolled away, and diabetes became a matter of the quality of life, not the speed of death.

A wheat belly represents the accumulation of fat that results from years of consuming foods that trigger insulin, the hormone of fat storage.

failure of insulin to lower blood glucose is called insulin resistance.

it seems to me that, on balance, soul/body dualism has been the enemy of compassion. For instance, the moral stigma that still surrounds disorders of mood and cognition seems largely the result of viewing the mind as distinct from the brain. When the pancreas fails to produce insulin, there is no shame in taking synthetic insulin to compensate for its lost function.

Most of all, immunize yourself from the drug companies efforts to convince you that you desperately need their advertised products. If you really needed the product, it is unlikely that drug companies would be spending money on advertising. Remember, there aren't many ads for insulin on TV.

A bad dream. To the person in the bell jar, blank and stopped as a dead baby, the world itself is a bad dream. A bad dream. I remembered everything. I remembered the cadavers and Doreen and the story of the fig-tree and Marco's diamond and the sailor on the Common and Doctor Gordon's wall-eyed nurse and the broken thermometers and the negro with his two kinds of beans and the twenty pounds I'd gained on insulin and the rock that bulged between sky and sea like a grey skull. Maybe forgetfulness, like a kind snow, should numb and cover them. But they were part of me. They were my landscape.

fat cells much more than passive storage sites for excess calories. Fat cells take in or release calories only when instructed to do so by external signals—and the master control is insulin. Too much insulin causes weight gain, whereas too little causes weight loss. So if we think about obesity as a disorder involving fat cells, then a radically different view emerges: Overeating doesn’t make us fat. The process of becoming fat makes us overeat.

Test Ideal level • fasting blood glucose less than 95 milligrams per deciliter (mg/dL) • fasting insulin below 8 µIU/ml (ideally, below 3) • hemoglobin A1C 4.8 to 5.4 percent • fructosamine 188 to 223 µmol/L • homocysteine 8µmol/L or less • vitamin D 80 ng/mL • C-reactive protein 0.00 to 3.0 mg/L • gluten sensitivity test with Cyrex array 3 test

Surgery, clamps, sutures, bandages, antibiotics Mop Sucking chest wound Anesthesia, surgery Cork Cancer Chemotherapy, radiation, surgery Casket wreath* 13 Diabetes Insulin Leeches* 14 Hatchet embedded in skull Removal of hatchet, treatment of wound Larger hat Eyes gouged out in hospital by psychopath posing as nurse Prosthetic eyeballs, therapy Six-pack Source:

Another, related issue is that longevity itself, and healthspan in particular, doesn’t really fit into the business model of our current healthcare system. There are few insurance reimbursement codes for most of the largely preventive interventions that I believe are necessary to extend lifespan and healthspan. Health insurance companies won’t pay a doctor very much to tell a patient to change the way he eats, or to monitor his blood glucose levels in order to help prevent him from developing type 2 diabetes. Yet insurance will pay for this same patient’s (very expensive) insulin after he has been diagnosed. Similarly, there’s no billing code for putting a patient on a comprehensive exercise program designed to maintain her muscle mass and sense of balance while building her resistance to injury. But if she falls and breaks her hip, then her surgery and physical therapy will be covered. Nearly all the money flows to treatment rather than prevention—and when I say “prevention,” I mean prevention of human suffering.

Here’s the basic strategy: 1.  Turn off the starvation response by eating whenever you’re hungry and until fully satisfied. 2.  Tame your fat cells with a diet that lowers insulin levels, reduces inflammation (insulin’s troublemaker twin), and redirects calories to the rest of your body. 3.  Follow a simple lifestyle prescription focused on enjoyable physical activities, sleep, and stress relief to improve metabolism and support permanent behavior change.

Where America really differs from other countries is in the colossal costs of its health care. An angiogram, a survey by The New York Times found, costs an average of $914 in the United States, $35 in Canada. Insulin costs about six times as much in America as it does in Europe. The average hip replacement costs $40,364 in America, almost six times the cost in Spain, while an MRI scan in the United States is, at $1,121, four times more than in the Netherlands. The entire system is notoriously unwieldy and cost-heavy. America has about 800,000 practicing physicians but needs twice that number of people to administer its payments system. The inescapable conclusion is that higher spending in America doesn’t necessarily result in better medicine, just higher costs.

When blood insulin levels are high, those same fat cells store not only the excess glucose but the fat you ate at your last meal. Moreover, high insulin signals the fat cells to hold on to the fat and not release it for energy. If the pattern of high insulin-generating meals continues, fat cells swell up and you gain weight.

The importance of insulin is becoming more well recognized. Unfortunately, some people are writing books that fail to distinguish between simple and complex carbohydrates. They recommend that people minimize intake of carbohydrates and increase intake of protein, even high-fat, high-cholesterol animal proteins, which is most unwise.

How to recognize a medical serial killer: • majority of cases take place in a hospital setting • attention-seeking behavior • odd behavior after a patient death or seeming “happy” • disciplinary record • thrill seeker • tendency to predict when a patient will die • frequently moving hospitals • insulin poisoning the most common method

...his condition in Roanoke is a strong testament that lassitude, indifference and the peculiarities of his thought were primarily the consequences of his illness and not of the early attempts to treat it. The popular view that anti-psychotics were chemical straight jackets that suppressed clear thinking and voluntary activity seems not to be borne out in Nash's case. If anything, the only periods when he was relatively free of hallucinations, delusions and the erosion of will were the periods following either insulin treatment or the use of anti psychotics. In other words, rather than reducing Nash to a zombie, medication seemed to reduce zombie like behavior.

sutures, bandages, antibiotics Mop Sucking chest wound Anesthesia, surgery Cork Cancer Chemotherapy, radiation, surgery Casket wreath* 13 Diabetes Insulin Leeches* 14 Hatchet embedded in skull Removal of hatchet, treatment of wound Larger hat Eyes gouged out in hospital by psychopath posing as nurse Prosthetic eyeballs, therapy Six-pack Source:

By 1991, for instance, epidemiologist surverys in populations had revealed that high cholesterol was NOT associated with heart disease or premature death in women. Rather, the higher the cholesterol in women, the longer they lived, a finding that was so consistent across populations and surveys that it prompted an editorial in the American Heart Associations journal, Circulation: "We are coming to realize," the three authors, led by UC San Francisco epidemiologist Stephen Hulley, wrote, "the the results of cardiovascular research in men, which represents the great majority of the effort thus far, may not apply to women.

After participants had been restricted to four to five hours of sleep for a week, the cells of these tired individuals had become far less receptive to insulin.

Fatty liver is a completely reversible process. Emptying the liver of its surplus glucose and dropping insulin levels returns the liver to normal. Hyperinsulinemia drives DNL, which is the primary determinant of fatty liver disease. Normalizing insulin levels reverses the fatty liver. Refined carbohydrates, which cause large increases in insulin, are far more sinister than dietary fat. High carbohydrate intake can increase DNL tenfold, whereas high fat consumption, with correspondingly low carbohydrate intake, does not change hepatic fat production

During calorie restriction and fasting, blood glucose and insulin levels decline precipitously.18 Lower insulin signaling decreases growth signaling but extends life span in several species of animals.19

Jack is ubiquitous. A shadow in the Walgreens line while I buy my insulin, the tall man waiting at the bus stop, the deep chuckle on my way to the UMass faculty meeting. Solidly nowhere, vanishingly everywhere.

When the pancreas fails to produce insulin, there is no shame in taking synthetic insulin to compensate for its lost function. Many people do not feel the same way about regulating mood with antidepressants (for reasons that appear quite distinct from any concern about potential side effects). If this bias has diminished in recent years, it has been because of an increased appreciation of the brain as a physical organ.

Two foods that slow the rate of neurogenesis are sugars and oxidized (damaged) fats. When oxidized fats get into your bloodstream, they cause inflammation. That inflammation slows your ability to make precious ATP, chews up the insides of your blood vessels, inhibits blood flow to the brain, and slows neurogenesis to a crawl. A high-sugar diet slows your rate of neurogenesis by increasing the amount of insulin in the bloodstream. Too

To understand why carbohydrates are the instrument of death, we need just a little science. Only recently have science and medicine begun to acknowledge a condition called chronic hyperinsulinemia. That's the term for chronic high insulin made in your own body. This can only occur when you chronically consume carbohydrates. You could never chronically consume carbohydrates in nature. Trees and plants fruit only in one season and flower in the other.

Insulin tells the body to stop burning its fat stores and instead absorb some of the fatty acids and glucose in the blood and turn them into more body fat…but that’s not what causes you to get fatter over time—overeating does. •

First, when you try to restrict calories and exercise more, your body is hardwired to perceive a starvation situation. That makes you tired (so you move less and conserve energy) and hungry (so you eat more), and it slows down your metabolism (so you don’t die!). This “eat less, exercise more” formula is not too successful for most people. It can work for a short time, certainly, but less than 10 percent of people lose weight and keep it off for a year;4 you will almost always rebound and gain back the weight. Second, when you eat carbs and sugar, insulin spikes and your blood sugar drops. The insulin drives most of the available fuel in your bloodstream into fat cells, especially the fat cells around your middle, otherwise known as belly fat. So your body is starved of fuel, and this stimulates your brain5 to make you eat more.6 You could have a year’s worth of stored energy in your fat tissue and yet feel like you are starving. The only thing that can stop this vicious cycle is eating a lot of fat and cutting out the refined carbs and sugar. A high-fat, low-carb diet leads to a faster metabolism and sustained weight loss.

People who regularly consume artificial sweeteners may find naturally sweet foods (like fruit) unappealing, and unsweet foods (like vegetables) intolerable. Artificial sweeteners may also cause insulin secretion, driving calories into fat cells and stimulating hunger.62 In addition, fat cells have been reported to contain sweet taste receptors—similar to those on the tongue. Artificial sweeteners may promote fat cell growth by stimulating these receptors or in other ways.

A daughter in an asylum! I had done that to her. Still, she had obviously decided to forgive me.                 “We’ll take up where we left off, Esther,” she had said, with her sweet, martyr’s smile. “We’ll act as if all this were a bad dream.”                 A bad dream.                 To the person in the bell jar, blank and stopped as a dead baby, the world itself is the bad dream.                 A bad dream.                 I remembered everything.                 I remembered the cadavers and Doreen and the story of the fig tree and Marco’s diamond and the sailor on the Common and Doctor Gordon’s wall-eyed nurse and the broken thermometers and the Negro with his two kinds of beans and the twenty pounds I gained on insulin and the rock that bulged between sky and sea like a gray skull.                 Maybe forgetfulness, like a kind snow, should numb and cover them.                 But they were part of me. They were my landscape.

The science tells us that obesity is ultimately the result of a hormonal imbalance, not a caloric one—specifically, the stimulation of insulin secretion caused by eating easily digestible, carbohydrate-rich foods: refined carbohydrates, including flour and cereal grains, starchy vegetables such as potatoes, and sugars, like sucrose (table sugar) and high-fructose corn syrup. These carbohydrates literally make us fat, and by driving us to accumulate fat, they make us hungrier and they make us sedentary.

Insulin’s effects on calorie storage are so potent that we can consider it the ultimate fat cell fertilizer. For example, rats given insulin infusions developed low blood glucose (hypoglycemia), ate more, and gained weight. Even when their food was restricted to that of the control animals, they still became fatter.9 Conversely, mice genetically engineered to produce less insulin had healthier fat cells, burned off more calories, and resisted weight gain, even when given a diet that makes normal mice fat.10

At the beginning of my illness, hospital visits couldn’t be avoided. I needed tests, I had to have my diet and insulin regulated, and once I fainted at school and went into insulin shock and the ambulance came and took me to St. Luke’s. If one of my friends got that sick, I would have called her in the hospital and sent her cards and visited her when she went home. But not Laine. She seemed almost afraid of me (although she tried to cover up by acting cool and snooty). And my other friends did what Laine did, because she was the leader. Their leader. My leader. And we were her followers. The school year grew worse and worse. I fainted twice more at school, each time causing a big scene and getting lots of attention, and every week, it seemed, I missed at least one morning while Mom and Dad took me to some doctor or clinic or other. Laine called me a baby, a liar, a hypochondriac, and a bunch of other things that indicated she thought my parents and I were making a big deal over nothing. But if she really thought it was nothing, why wouldn’t she come over to my apartment anymore? Why wouldn’t she share sandwiches or go to the movies with me? And why did she move her desk away from mine in school? I was confused and unhappy and sick, and I didn’t have any friends left, thanks to Laine. I hated Laine.

If David had been diagnosed with diabetes at a young age, members of his family, school, and church would have undoubtedly mobilized support. His caregivers would have communicated his need for dietary changes, exercise, and/or insulin. This was not the case when David exhibited the earliest signs of depression. The myth persists that mental illness is a character flaw. It is my hope that one day disorders of the brain will be treated with as much care, compassion, and tenacity as diseases of any other organs in our bodies.

The bottom line is something that’s been known (and mostly ignored) for over forty years. The one thing we absolutely have to do if we want to get leaner—if we want to get fat out of our fat tissue and burn it—is to lower our insulin levels and to secrete less insulin to begin with.

Because the insulin level in the bloodstream is determined primarily by the carbohydrates that are consumed—their quantity and quality, as I’ll discuss—it’s those carbohydrates that ultimately determine how much fat we accumulate. Here’s the chain of events: 1.  You think about eating a meal containing carbohydrates. 2. You begin secreting insulin. 3. The insulin signals the fat cells to shut down the release of fatty acids (by inhibiting HSL) and take up more fatty acids (via LPL) from the circulation. 4. You start to get hungry, or hungrier. 5. You begin eating. 6. You secrete more insulin. 7. The carbohydrates are digested and enter the circulation as glucose, causing blood sugar levels to rise.§ 8. You secrete still more insulin. 9. Fat from the diet is stored as triglycerides in the fat cells, as are some of the carbohydrates that are converted into fat in the liver. 10.  The fat cells get fatter, and so do you. 11.  The fat stays in the fat cells until the insulin level drops. If

In the absence of any therapy, the mentally ill of the 20th century were chained, shackled, straitjacketed, kept nude, electrocuted, half-frozen, parboiled, violently hosed, wrapped in wet canvas, confined to “mummy bags”, subjected to insulin-induced hypoglycemic comas, forced into seizures with massive doses of the stimulant Metrazol, injected with camphor, drugged into three-week comas with barbiturates and tranquilizers, involuntarily sterilized, and surgically mutilated. Rape by hospital staff was common, as was humiliation and verbal abuse. One reporter noted that a state hospital patient had been restrained for so long that his skin was beginning to grow around the leather straps.

The factor VIII project, both teams knew, would challenge the outer limits of gene-cloning technology. Somatostatin had 14 amino acids; insulin had 51. Factor VIII had 2,350. The leap in size between somatostatin and factor VIII was 160-fold-almost equivalent to the jump in distance between Wilbur Wright's first airborne circle at Kitty Hawk and Lindbergh's journey across the Atlantic.

Many women, worried about breast cancer, have adopted vegetarian diets in an attempt to reduce their risk. Unfortunately, it may be that these grain- and starch-based diets actually increase the risk of breast cancer, because they elevate insulin—which, in turn, increases IGF-1 and lowers IGFBP-3. A large epidemiological study of Italian women, led by Dr. Silvia Franceschi, has shown that eating large amounts of pasta and refined bread raises the risk of developing both breast and colorectal cancer. Most vegetarian diets are based on starchy grains and legumes. Sadly—despite continuing perceptions of these as healthy foods—vegetarian diets don’t reduce the risk of cancer. In the largest-ever study comparing the causes of death in more than 76,000 people, it was decisively shown that there were no differences in death rates from breast, prostate, colorectal, stomach, or lung cancer between vegetarians and meat eaters. Cancer is a complex process involving many genetic and environmental factors. It is almost certain that no single dietary element is responsible for all cancers. However, with the low-glycemic Paleo Diet, which is also high in lean protein and health-promoting fruits and vegetables, your risk of developing many types of cancer may be very much reduced.

Cortisol works more systemically than adrenaline does. It triggers the liver to make more glucose available in the bloodstream while it also blocks insulin receptors in nonessential organs and tissues so that you get all the glucose (fuel) that you need to deal with the threat. Cortisol’s work is a long-term strategy of insulin resistance, which serves to provide the brain with a sustained level of glucose. However, you don’t always have a lot of glucose floating around, so cortisol works to stockpile energy. It converts protein into glycogen and begins to store fat. If the stress is chronic, the increased body fat is stored in the abdomen. If you have a growing bulge in your midsection, it may be due to cortisol working to store energy. Unfortunately, that’s not the way you want it to be stored. It’s better to burn off such stored energy by exercise.

It is for such reasons that I always ask my clinical clients first about sleep. Do they wake up in the morning at approximately the time the typical person wakes up, and at the same time every day? If the answer is no, fixing that is the first thing I recommend. It doesn’t matter so much if they go to bed at the same time each evening, but waking up at a consistent hour is a necessity. Anxiety and depression cannot be easily treated if the sufferer has unpredictable daily routines. The systems that mediate negative emotion are tightly tied to the properly cyclical circadian rhythms. The next thing I ask about is breakfast. I counsel my clients to eat a fat and protein-heavy breakfast as soon as possible after they awaken (no simple carbohydrates, no sugars, as they are digested too rapidly, and produce a blood-sugar spike and rapid dip). This is because anxious and depressed people are already stressed, particularly if their lives have not been under control for a good while. Their bodies are therefore primed to hypersecrete insulin, if they engage in any complex or demanding activity. If they do so after fasting all night and before eating, the excess insulin in their bloodstream will mop up all their blood sugar. Then they become hypoglycemic and psych​ophys​iologi​cally unstable.

Imagine if the government chased sick people with diabetes, put a tax on insulin and drove it into the black market, told doctors they couldn't treat them, and then caught them, prosecuted them for not paying their taxes, and then sent them to jail. If we did that, everyone would know we were crazy. Yet we do practically the same thing every day in the week to sick people hooked on drugs. The jails are full and the problem is getting worse every day. p153

What they found was striking: higher levels of the inactive form of IRS-1 (signifying impaired insulin signaling in the brain) predicted Alzheimer’s disease development in patients with 100 percent accuracy.20 Even more breathtaking, the difference in these blood markers was evident ten years prior to the emergence of symptoms. This suggests that maintaining the brain’s insulin sensitivity throughout life may be a major step toward preventing the disease.

Carbohydrates are not required in a healthy human diet. Another way to say this (as proponents of carbohydrate restriction have) is that there is no such thing as an essential carbohydrate. Nutritionists will say that 120 to 130 grams of carbohydrates are required in a healthy diet, but this is because they confuse what the brain and central nervous system will burn for fuel when diets are carbohydrate rich—120 to 130 grams daily—with what we actually have to eat. If there are no carbohydrates in the diet, the brain and central nervous system will run on molecules called “ketones.” These are synthesized in the liver from the fat we eat and from fatty acids, mobilized from the fat tissue because we’re not eating carbohydrates and insulin levels are low, and even from some amino acids. With no carbohydrates in the diet, ketones will provide roughly three-quarters of the energy that our brains use. And this is why severely carbohydrate-restricted diets are known as “ketogenic” diets. The rest of the energy required will come from glycerol, which is also being released from the fat tissue when the triglycerides are broken down into their component parts, and from glucose synthesized in the liver from the amino acids in protein. Because a diet that doesn’t include fattening carbohydrates will still include plenty of fat and protein, there will be no shortage of fuel for the brain.

nonalcoholic fatty liver disease has become the most common chronic liver disease in the world, increasing from 25 percent of the global population in 1990 to close to 40 percent by 2019. NAFLD is full-blown metabolic dysfunction in kids and adults, representing liver cells filling with fat, which worsens insulin resistance. Key contributors are processed foods, refined sugars, refined grains, sweet beverages, high-fructose corn syrup, fast food, low fiber and phytochemical intake, habitual eating close to bedtime, sedentary behavior, and oxidative stress. Liver transplants have gone up close to 50 percent in the past fifteen years, and while alcohol and hepatitis C used to be the leading causes, now NAFLD is taking the lead in women as the cause of liver failure and is a top cause for men. Fatty liver disease is now the most common cause of liver transplant in young adults in the United States. We are failing our children.

For nearly a hundred years, psychiatry has been striving to apply medical model thinking to psychiatric disorders. In this model, the symptoms besieging patients are sorted into specific disease entities and the causes then identified and removed. For doctors of internal medicine, this works. In the case of diabetes mellitus, for example, the symptoms of urinary frequency, fatigue, and confusion often lead to suspicion of the underlying cause, which is confirmed by blood sugar monitoring and then treated by insulin replacement. But psychiatric symptoms are much harder to sort into diagnoses. People with depression sometimes become paranoid. People with schizophrenia sometimes become depressed. Some people who hear voices have no other symptoms whatsoever, and others who hear voices also fall victim to terrible mood swings. Thus far, the hope that psychiatry would be able to identify homogeneous disease states, uncover the biological underpinnings, and remedy them has been largely a barren one. Kappler's symptoms, however, evolved when the hope for psychiatry's becoming a true medical specialty was bright to the point of being blinding. Over the years he would collect over a dozen diagnoses and cavalierly take a myriad of medicines, but no one would be able to bring him close to confronting the past he had disowned, to stand a chance of making peace with it and, ultimately, overcoming it. (46)

THE RESULTS ARE very consistent. Drugs that raise insulin levels cause weight gain. Drugs that have no effect on insulin levels are weight neutral. Drugs that lower insulin levels cause weight loss. The effect on weight is independent of the effect on blood sugar. A recent study suggests that 75 per cent of the weight-loss response in obesity is predicted by insulin levels.29 Not willpower. Not caloric intake. Not peer support or peer pressure. Not exercise. Just insulin.

Pucetti’s was the generation that was all in favour of sentiment, sharing other people’s pain, voicing compassion for the downtrodden, yet Brunetti often found in them traces of a ruthlessness that chilled his spirit and made him fearful for the future. He wondered if the cheap sentimentality of television and film had sent them into some sort of emotional insulin shock and suffocated their ability to feel empathy with the unappealing victims of the mess that real life created.

DO YOU HAVE OR HAVE YOU EXPERIENCED IN THE PAST SIX MONTHS . . . — PART A — ■ A feeling you’re constantly racing from one task to the next? ■ Feeling wired yet tired? ■ A struggle calming down before bedtime, or a second wind that keeps you up late? ■ Difficulty falling asleep or disrupted sleep? ■ A feeling of anxiety or nervousness—can’t stop worrying about things beyond your control? ■ A quickness to feel anger or rage—frequent screaming or yelling? ■ Memory lapses or feeling distracted, especially under duress? ■ Sugar cravings (you need “a little something” after each meal, usually of the chocolate variety)? ■ Increased abdominal circumference, greater than 35 inches (the dreaded abdominal fat, or muffin top—not bloating)? ■ Skin conditions such as eczema or thin skin (sometimes physiologically and psychologically)? ■ Bone loss (perhaps your doctor uses scarier terms, such as osteopenia or osteoporosis)? ■ High blood pressure or rapid heartbeat unrelated to those cute red shoes in the store window? ■ High blood sugar (maybe your clinician has mentioned the words prediabetes or even diabetes or insulin resistance)? Shakiness between meals, also known as blood sugar instability? ■ Indigestion, ulcers, or GERD (gastroesophageal reflux disease)? ■ More difficulty recovering from physical injury than in the past? ■ Unexplained pink to purple stretch marks on your belly or back? ■ Irregular menstrual cycles? ■ Decreased fertility?

The conditions in the womb—in the intrauterine environment—influence the development of the fetus, so that subtly different conditions will lead, in effect, to the birth of newborns who respond differently to the environment they face outside the womb. In particular, the nutrients that the developing child receives in the womb—including the supply of glucose—pass across the placenta in proportion to the nutrient concentration in the mother’s circulation. The higher the mother’s blood sugar, the greater the supply of glucose to the fetus. The developing pancreas responds by overproducing insulin-secreting cells. “The baby is not diabetic,” says Boyd Metzger, who studies diabetes and pregnancy at Northwestern University, “but the insulin-producing cells in the pancreas are stimulated to function and grow in size and number by the environment they’re in. So they start overfunctioning. That in turn leads to a baby laying down more fat, which is why the baby of a diabetic mother is typified by being a fat baby.

Below are recommended optimal ranges for key metabolic blood tests. Falling outside of these ranges is an indicator that you could have brewing dysfunction. The remainder of Part 2 and the plan in Part 3 will give specific steps to increase Good Energy and improve these biomarkers: Triglycerides: Less than 80 mg/dL HDL: 50 to 90 mg/dL Fasting Glucose: 70 to 85 mg/dL Blood Pressure: Less than 120 systolic and less than 80 diastolic mmHg Waist Circumference: <80 cm (31.5 inches) for women and <90 cm (35 inches) for men (South Asian, Chinese, Japanese, and South and Central Americans) <80 cm (31.5 inches) for women and <94 cm (37 inches) for men (European, Sub-Saharan African, Middle Eastern, and Eastern Mediterranean) Triglyceride-to-HDL Ratio: Below 1.5. Above 3 is a clear sign of metabolic dysfunction. Fasting Insulin: From 2 to 5 mIU/L. Above 10 mIU/L is concerning and above 15 mIU/L is significantly elevated. HOMA-IR: Less than 2.0 High-Sensitivity CRP (hsCRP): Less than 0.3 mg/dL Hemoglobin A1c: From 5.0 to 5.4 percent Uric Acid: Less than 5 mg/dL for men, and from 2 to 4 mg/dL for women

To the person in the bell jar, blank and stopped as a dead baby, the world itself is the bad dream. A bad dream I remembered everything. I remembered the cadavers and Doreen and the story of the fig tree an Marco's diamond and the sailor on the Common and Doctor Gordon's wall-eyed nurse and the broken thermometers and the Negro with his two kinds of beans and the twenty pounds I gained on insulin and the rock that bulged between sky and sea like a gray skull. Maybe forgetfulness, like a kind snow, should numb and cover them. But they were part of me. They were my landscape.

The explanation may be that gene activity in our muscles changes when the muscles don’t contract for long periods of time. In one experiment, researchers at the University of Massachusetts asked a group of healthy young men to walk around using crutches such that the muscles in their left legs never contracted. After only two days of inactivity, the scientists biopsied muscles in both legs. In the left leg, the DNA repair mechanism had been disrupted, insulin response was dropping, oxidative stress was rising, and metabolic activity within individual muscle cells was slowing.

1) Levophed—a common blood pressure medication. Used to be called “leave ’em dead” because people used it for the sickest of the sick in sepsis and those patients still frequently died, but it has now come back into favor. We were maxed. 2) Vasopressin—another BP med. Not titratable. Left on normal dose. 3) Phenylephrine, aka Neo, from its brand name, Neosynephrine—another BP med—maxed. Pharmacy was mixing higher concentrations of this for us, so that we could give it in less fluid volume for the patient’s sake. 4) Sodium Bicarb—also high-concentrated dose for fluid reasons—given to attempt to combat patient’s acidosis. 5) Fentanyl—pain control—not maxed. 6) Versed—an amnesiac—hopefully makes you “less aware” of WTF is happening to you. Also not maxed, because they were also on…. 7) Nimbex—a paralytic we give to patients to make them “ride the vent” so that they don’t fight it and can save energy, as the vent does the work of breathing for them. 8) Heparin—blood thinner, to reduce the clotting that covid can cause. 9) Amiodarone—heart med, stops arrhythmias. 10) Insulin—which requires hourly insulin checks to titrate effectively. Unfortunately, many covid patients are also on steroids, which means their blood sugars fluctuate all over the place.

In a study published in the American Journal of Clinical Nutrition,79 we followed 276 middle-aged adults in Quebec for six years, dividing them into categories based on diet. Overall, the participants gained about 6 pounds (quite typical for this age group), but with huge individual variation—ranging from a 20-pound weight loss to a 30-pound weight gain. For those consuming a high-carbohydrate/low-fat diet, Insulin-30 strongly predicted this variation. That is, people with low insulin secretion gained on average virtually no weight, whereas those with high insulin secretion gained on average more than 10 pounds. In contrast, Insulin-30 had no relationship to weight gain among those consuming a low-carbohydrate/high-fat diet.

This situation is similar to edema, a condition in which fluid leaks out of the blood vessels and accumulates elsewhere in the body (for example, in the legs), causing swelling. Despite having too much water in the body, people with edema may experience unquenchable thirst, because there’s not enough water in the blood, where it’s needed. Telling people with edema to drink less is no more effective than food restriction for weight loss, because it ignores the underlying cause. Insulin (and other influences, as we’ll discuss later) has programmed fat cells into calorie-storage overdrive. People chronically overeat because they’re trying to keep enough calories in the blood to feed the brain, compensating for those being siphoned off by overstimulated fat cells.

Tell you what: Ask a Baptist wife why her husband treats her like a personal slave. Ask a homosexual couple why their love for one another is treated as a sick joke in some parts of the world and as a crime punishable by death in others. Ask a starving African mother with ten starving children why she doesn't practice birth control. Ask a young Muslim girl why her parents sliced off her clitoris. Ask millions of Muslim women why they cannot attend schools or show themselves in public except through the eye slits of a full-body burqa. Ask the Pakistani woman who's gang-raped why she is sentenced to death while her rapists go free, and why it’s her own family leading the murderous chorus. Ask the American woman who’s raped why her local congressman would question the “legitimacy” of that rape and would force her to bring her rapist’s child to term. Ask the dead Christian children why their fundamentalist parents wouldn’t give them an antibiotic to stave off their infection or an insulin injection to control their diabetes. Ask the Parkinson’s or paralysis victims why their cures have been mired in religious and political red tape for decades now because an increasingly hysterical and radical segment of American society believes that a clump of cells with no identity and no consciousness has more rights than they do. Ask them all to point to the source of their misery, and then ask yourself why it doesn't bother you that they are pointing to the same goddamned book you're using in your religious services and in the celebration of your “harmless” and “quaint” traditions.

Triglyceride-to-HDL Ratio After assessing each of these five biomarkers, there is one more step: calculate your triglyceride-to-HDL ratio to better understand insulin sensitivity. Simply divide your triglycerides by your HDL. Interestingly, studies have shown that this value correlates well with underlying insulin resistance. So even if you are unable to access a fasting insulin test, the triglyceride-to-HDL ratio can give you a general sense of where you’re at. According to Dr. Mark Hyman, “the triglyceride-to-HDL ratio is the best way to check for insulin resistance other than the insulin response test. According to a paper published in Circulation, the most powerful test to predict your risk of a heart attack is the ratio of your triglycerides to HDL. If the ratio is high, your risk for a heart attack increases sixteen-fold—or 1,600 percent! This is because triglycerides go up and HDL (or ‘good cholesterol’) goes down with diabesity.” Dr. Robert Lustig agrees: “The triglyceride-to-HDL ratio is the best biomarker of cardiovascular disease and the best surrogate marker of insulin resistance and metabolic syndrome.” In children, higher triglyceride-to-HDL is significantly correlated with mean insulin, waist circumferences, and insulin resistance. In adults, the ratio has shown a positive association with insulin resistance across normal weight and overweight people and significantly tracks with insulin levels, insulin sensitivity, and prediabetes. Perplexingly, the triglyceride-to-HDL ratio is not a metric used in standard clinical practice. If you remember one thing from this chapter, remember this: you need to know your insulin sensitivity. It can give you lifesaving clues about early dysfunction and Bad Energy brewing in your body, and is best assessed by a fasting insulin test, discussed below. Right now, this is not a standard test offered to you at your annual physical. I implore you to find a way to get a fasting insulin test or to calculate your triglyceride-to-HDL ratio every year. Do this for your children, as well. And take the steps outlined in the following chapters to ensure it does not start creeping up. RANGES: Range considered “normal” by standard criteria: none specified in standard criteria Optimal range: Anything above a ratio of 3 is strongly suggestive of insulin resistance. You want to shoot for less than 1.5, although lower is better. I recommend aiming for less than 1.

The ingestion of carbohydrates, especially the refined grains and sugars that are so prominent in the modern diet, causes a spike in blood sugar and a temporary energy boost. Then, because a glucose overdose is toxic in the bloodstream, insulin floods the bloodstream to remove any glucose you don’t burn immediately and stores it as either glycogen (in the liver and muscle tissues) or in the fat cells as triglyceride (the storage form of fat). When insulin removes glucose from your bloodstream and transports it into storage, you experience the familiar sugar crash and a craving for quick-energy carbohydrates. You have plenty of fat energy locked away in storage, but a high-insulin-producing diet prevents you from being able to access it. Instead, you become reliant on your next snack or meal for energy, and you exist in a state of carbohydrate dependency.

Let’s consider what happens to our metabolism when we eat carbohydrate, or, in particular, the carbohydrate in grains. Most of the carbohydrate contained in grains exists in the form of starch, which is just a large chain of glucose molecules. Starch is quickly broken down into its individual glucose units by enzymes in our saliva and those released by the pancreas. The glucose is then absorbed into the blood, causing a rise in “blood sugar.” The spike in blood sugar triggers the release of insulin from the pancreas, a hormone whose primary function is to remove glucose from the bloodstream by facilitating its transport into the bodily tissues. Once inside the tissues, the glucose can then be burned for energy. Once those tissues have their fill of glucose, however, any that’s left over in the blood must still be eliminated. Glucose that stays around too long ends up sticking to bodily tissues and causing irreversible damage. So how does our body get rid of this excess glucose? It stores it…as fat. Yes, that’s right. Any starch you consume that’s in excess of what your body needs is, under the direction of insulin, converted to fat. And, in addition to driving the storage of glucose as fat, insulin also suppresses the release of fat from the adipose tissue.

Working independently, Baltimore and Temin discovered an enzyme found in retroviruses that could build DNA from an RNA template. They called the enzyme reverse transcriptase-"reverse" because it inverted the normal direction of information flow: from RNA back to DNA, or from a gene's message backward to a gene, thereby violating Crick's "central dogma" (that genetic information only moved from genes to messages, but never backward). Using reverse transcriptase, ever RNA in a cell could be used as a template to build its corresponding gene. A biologist could thus generate a catalog, or "library" of all "active" genes in a cell-akin to a library of books grouped by subject. There would be a library of genes for T cells and another for red blood cells, a library for neurons in the retina, for insulin-secreting cells of the pancreas, and so forth. By comparing libraries derived from two cells-a T cell and a pancreas cell, say-an immunologist could fish out genes that were active in one cell and not the other (e.g., insulin or the T cell receptor). Once identified, that gene could be amplified a millionfold in bacteria. The gene could be isolated and sequenced, its RNA and protein sequence determined, its regulatory regions identified; it could be mutated an inserted into a different cell to decipher the gene's structure and function. In 1984 this technique was deployed to clone the T cell receptor-a landmark achievement in immunology.

REPROGRAMMING MY BIOCHEMISTRY A common attitude is that taking substances other than food, such as supplements and medications, should be a last resort, something one takes only to address overt problems. Terry and I believe strongly that this is a bad strategy, particularly as one approaches middle age and beyond. Our philosophy is to embrace the unique opportunity we have at this time and place to expand our longevity and human potential. In keeping with this health philosophy, I am very active in reprogramming my biochemistry. Overall, I am quite satisfied with the dozens of blood levels I routinely test. My biochemical profile has steadily improved during the years that I have done this. For boosting antioxidant levels and for general health, I take a comprehensive vitamin-and-mineral combination, alpha lipoic acid, coenzyme Q10, grapeseed extract, resveratrol, bilberry extract, lycopene, silymarin (milk thistle), conjugated linoleic acid, lecithin, evening primrose oil (omega-6 essential fatty acids), n-acetyl-cysteine, ginger, garlic, l-carnitine, pyridoxal-5-phosphate, and echinacea. I also take Chinese herbs prescribed by Dr. Glenn Rothfeld. For reducing insulin resistance and overcoming my type 2 diabetes, I take chromium, metformin (a powerful anti-aging medication that decreases insulin resistance and which we recommend everyone over 50 consider taking), and gymnema sylvestra. To improve LDL and HDL cholesterol levels, I take policosanol, gugulipid, plant sterols, niacin, oat bran, grapefruit powder, psyllium, lecithin, and Lipitor. To improve blood vessel health, I take arginine, trimethylglycine, and choline. To decrease blood viscosity, I take a daily baby aspirin and lumbrokinase, a natural anti-fibrinolytic agent. Although my CRP (the screening test for inflammation in the body) is very low, I reduce inflammation by taking EPA/DHA (omega-3 essential fatty acids) and curcumin. I have dramatically reduced my homocysteine level by taking folic acid, B6, and trimethylglycine (TMG), and intrinsic factor to improve methylation. I have a B12 shot once a week and take a daily B12 sublingual. Several of my intravenous therapies improve my body’s detoxification: weekly EDTA (for chelating heavy metals, a major source of aging) and monthly DMPS (to chelate mercury). I also take n-acetyl-l-carnitine orally. I take weekly intravenous vitamins and alpha lipoic acid to boost antioxidants. I do a weekly glutathione IV to boost liver health. Perhaps the most important intravenous therapy I do is a weekly phosphatidylcholine (PtC) IV, which rejuvenates all of the body’s tissues by restoring youthful cell membranes. I also take PtC orally each day, and I supplement my hormone levels with DHEA and testosterone. I take I-3-C (indole-3-carbinol), chrysin, nettle, ginger, and herbs to reduce conversion of testosterone into estrogen. I take a saw palmetto complex for prostate health. For stress management, I take l-theonine (the calming substance in green tea), beta sitosterol, phosphatidylserine, and green tea supplements, in addition to drinking 8 to 10 cups of green tea itself. At bedtime, to aid with sleep, I take GABA (a gentle, calming neuro-transmitter) and sublingual melatonin. For brain health, I take acetyl-l-carnitine, vinpocetine, phosphatidylserine, ginkgo biloba, glycerylphosphorylcholine, nextrutine, and quercetin. For eye health, I take lutein and bilberry extract. For skin health, I use an antioxidant skin cream on my face, neck, and hands each day. For digestive health, I take betaine HCL, pepsin, gentian root, peppermint, acidophilus bifodobacter, fructooligosaccharides, fish proteins, l-glutamine, and n-acetyl-d-glucosamine. To inhibit the creation of advanced glycosylated end products (AGEs), a key aging process, I take n-acetyl-carnitine, carnosine, alpha lipoic acid, and quercetin. MAINTAINING A POSITIVE “HEALTH SLOPE” Most important,