Immune System Short Quotes

Companies can learn a lot from biological systems. The human immune system for example is adaptive, redundant, diverse, modular, data-driven and network collaborative. A company that desires not just short term profit but also long term resilience should apply these features of the human immune system to it's business models and company structure.

It’s important and compassionate to treat symptoms in the short term, but in the long term, you have to treat the cause of disease, which is often more hidden.

In the short term, adrenaline gives our immune function a boost to help fight bacterial and viral infections. But in the longer term, over-production of adrenaline and abnormal patterns of cortisol are linked with shorter life expectancy (Kumari et al., 2011). When adrenaline is repeatedly propping up our immune system through chronic stress and then we stop and the adrenaline goes down, so does the immune system. This is why you often hear of people who work incredibly hard around the clock for months on end and when they finally stop to take a holiday they almost immediately fall ill.

This feeling of stress triggers a cascade of physiological consequences. The hypothalamus and pituitary gland in the brain release hormones that cause the release of cortisol from the adrenal glands located on the kidneys. Cortisol increases heart rate, among other things, readying the body for “fight” or “flight.” Acutely, the release of cortisol is beneficial and helps you cope with whatever is urgently being demanded of you. But if the stress becomes chronic, maladaptive things begin to happen. Normally, the release of cortisol turns the hypothalamus and pituitary off, stopping the release of hormone, which in turn stops the further release of cortisol from the adrenal glands. It’s a nice, clean, negative feedback loop. But in the chronically stressed, the loop breaks. The brain stops reacting to cortisol. Our natural, automatic shutoff valve stops working. The brain keeps releasing hormone, and the adrenal glands keep dumping cortisol into the bloodstream, even when the stressful thing that initially triggered the stress response is no longer around. Chronic, elevated levels of cortisol have been associated with a weakened immune system, deficits in short-term memory, chronic fatigue syndrome, anxiety disorders, and depression.

What’s important to note about Pennebaker’s research is the fact that he advocates limited writing, or short spurts. He’s found that writing about emotional upheavals for just fifteen to twenty minutes a day on four consecutive days can decrease anxiety, rumination, and depressive symptoms and boost our immune systems.

Stress often produces short-term “fight-or-flight” responses; when the threat passes, the body tends to return to equilibrium. But evidence started to accumulate that trauma could cause long-lasting bodily change, including to brain neurocircuitry, the sympathetic nervous system, the immune system, and the hypothalamic-pituitary-adrenal axis.

All of the elements that these cells manufacture are proteins. Proteins control our immune system, digest our food, heal our wounds, catalyze chemical reactions, support the structural integrity of our bodies, provide elegant molecules to communicate between cells, and much more. In short, proteins are the expression of life (and the health of our bodies).

including salutary effects on the following: • major depression • drug addiction • binge eating • smoking cessation • stress among cancer patients • loneliness among senior citizens • ADHD • asthma • psoriasis • irritable bowel syndrome Studies also indicated that meditation reduced levels of stress hormones, boosted the immune system, made office workers more focused, and improved test scores on the GRE. Apparently mindfulness did everything short of making you able to talk to animals and bend spoons with your mind. This research boom got its start with a Jew-Bu named Jon Kabat-Zinn, a Manhattan-raised, MIT-trained microbiologist who claimed to have had an elaborate epiphany—a “vision,” he called it—while on a retreat in 1979. The substance of the vision was that he could bring meditation to a much broader audience by stripping it of Buddhist metaphysics. Kabat-Zinn designed something called Mindfulness Based Stress Reduction (MBSR), an eight-week course that taught secularized meditation to tens of thousands of people around America and the world. Having a simple, replicable meditation protocol made it easy to test the effects on patients.

The races I study still employ their immune systems, and the parallels between those systems and us as a race are striking. For we have become what Earthlings would call white blood cells. We remove foreign bodies from the cosmos. And every one leaves an imprint, a bauble of tech or a new idea, all of which we neatly coil into our lives, into our molecular structure. We are an immune system, and we are immune to death. This last, alas, is our curse.

Ionizing radiation takes three principal forms: alpha particles, beta particles, and gamma rays. Alpha particles are relatively large, heavy, and slow moving and cannot penetrate the skin; even a sheet of paper could block their path. But if they do manage to find their way inside the body by other means—if swallowed or inhaled—alpha particles can cause massive chromosomal damage and death. Radon 222, which gathers as a gas in unventilated basements, releases alpha particles into the lungs, where it causes cancer. Polonium 210, a powerful alpha emitter, is one of the carcinogens in cigarette smoke. It was also the poison slipped into the cup of tea that killed former FSB agent Alexander Litvinenko in London in 2006. Beta particles are smaller and faster moving than alpha particles and can penetrate more deeply into living tissue, causing visible burns on the skin and lasting genetic damage. A piece of paper won’t provide protection from beta particles, but aluminum foil—or separation by sufficient distance—will. Beyond a range of ten feet, beta particles can cause little damage, but they prove dangerous if ingested in any way. Mistaken by the body for essential elements, beta-emitting radioisotopes can become fatally concentrated in specific organs: strontium 90, a member of the same chemical family as calcium, is retained in the bones; ruthenium is absorbed by the intestine; iodine 131 lodges particularly in the thyroid of children, where it can cause cancer. Gamma rays—high-frequency electromagnetic waves traveling at the speed of light—are the most energetic of all. They can traverse large distances, penetrate anything short of thick pieces of concrete or lead, and destroy electronics. Gamma rays pass straight through a human being without slowing down, smashing through cells like a fusillade of microscopic bullets. Severe exposure to all ionizing radiation results in acute radiation syndrome (ARS), in which the fabric of the human body is unpicked, rearranged, and destroyed at the most minute levels. Symptoms include nausea, vomiting, hemorrhaging, and hair loss, followed by a collapse of the immune system, exhaustion of bone marrow, disintegration of internal organs, and, finally, death.

Self-Management If you can read just one book on motivation—yours and others: Dan Pink, Drive If you can read just one book on building new habits: Charles Duhigg, The Power of Habit If you can read just one book on harnessing neuroscience for personal change: Dan Siegel, Mindsight If you can read just one book on deep personal change: Lisa Lahey and Bob Kegan, Immunity to Change If you can read just one book on resilience: Seth Godin, The Dip Organizational Change If you can read just one book on how organizational change really works: Chip and Dan Heath, Switch If you can read just two books on understanding that change is a complex system: Frederic Laloux, Reinventing Organizations Dan Pontefract, Flat Army Hear interviews with FREDERIC LALOUX, DAN PONTEFRACT, and JERRY STERNIN at the Great Work Podcast. If you can read just one book on using structure to change behaviours: Atul Gawande, The Checklist Manifesto If you can read just one book on how to amplify the good: Richard Pascale, Jerry Sternin and Monique Sternin, The Power of Positive Deviance If you can read just one book on increasing your impact within organizations: Peter Block, Flawless Consulting Other Cool Stuff If you can read just one book on being strategic: Roger Martin and A.G. Lafley, Playing to Win If you can read just one book on scaling up your impact: Bob Sutton and Huggy Rao, Scaling Up Excellence If you can read just one book on being more helpful: Edgar Schein, Helping Hear interviews with ROGER MARTIN, BOB SUTTON, and WARREN BERGER at the Great Work Podcast. If you can read just two books on the great questions: Warren Berger, A More Beautiful Question Dorothy Strachan, Making Questions Work If you can read just one book on creating learning that sticks: Peter Brown, Henry Roediger and Mark McDaniel, Make It Stick If you can read just one book on why you should appreciate and marvel at every day, every moment: Bill Bryson, A Short History of Nearly Everything If you can read just one book that saves lives while increasing impact: Michael Bungay Stanier, ed., End Malaria (All money goes to Malaria No More; about $400,000 has been raised so far.) IF THERE ARE NO STUPID QUESTIONS, THEN WHAT KIND OF QUESTIONS DO STUPID PEOPLE ASK?

James Pennebaker, a researcher at the University of Texas at Austin and author of Writing to Heal, has done some of the most important and fascinating research I’ve seen on the power of expressive writing in the healing process. In an interview posted on the University of Texas’s website, Pennebaker explains, “Emotional upheavals touch every part of our lives. You don’t just lose a job, you don’t just get divorced. These things affect all aspects of who we are—our financial situation, our relationships with others, our views of ourselves, our issues of life and death. Writing helps us focus and organize the experience.” Pennebaker believes that because our minds are designed to try to understand things that happen to us, translating messy, difficult experiences into language essentially makes them “graspable.” What’s important to note about Pennebaker’s research is the fact that he advocates limited writing, or short spurts. He’s found that writing about emotional upheavals for just fifteen to twenty minutes a day on four consecutive days can decrease anxiety, rumination, and depressive symptoms and boost our immune systems.

Well, start with a cell again. Inside the cell is a nucleus, and inside each nucleus are the chromosomes—forty-six little bundles of complexity, of which twenty-three come from your mother and twenty-three from your father. With a very few exceptions, every cell in your body—99.999 percent of them, say—carries the same complement of chromosomes. (The exceptions are red blood cells, some immune system cells, and egg and sperm cells, which for various organizational reasons don’t carry the full genetic package.) Chromosomes constitute the complete set of instructions necessary to make and maintain you and are made of long strands of the little wonder chemical called deoxyribonucleic acid or DNA—“the most extraordinary

Dr. W. B. Clarke's research into the problems of childhood vaccines, came across the evidence that all vaccines given over a short period of time to an immature immune system deplete the thymus gland, (the primary gland of the immune reactions) of irreplaceable immature immune cells. Each of these cells could have multiplied and developed into an army of valuable cells to combat infection and growth of abnormal cells. When these cells are used up permanent immunity may not appear. Work at the Arthur Research Foundation in Tucson, Arizona estimates that up to 60% of our immune system may be exhausted by multiple mass vaccinations. With naturally acquired immunity, only 10% of immune cells are lost. This constitutes a grave concern for vaccinations ruining the immune system

Oxford philosopher Timothy Williamson suggests that scepticism initially looks appealing (despite its bleak consequences) because it is a good thing carried too far. The good thing is that we have a healthy critical ability to double-check individual things we believe by suspending judgement in them temporarily to see whether they really fit with the rest of what we know. But if this ability to suspend individual beliefs serves as a useful immune system to weed out inconsistent and ungrounded ideas, scepticism is like an autoimmune disease in which the protective mechanism goes too far and attacks the healthy parts of the organism. Once we have suspended too much—for example, once we have brought into doubt the reality of the whole outer world—we no longer have the resources to reconfirm or support any of the perfectly reasonable things we believe.

The Transition to Fewer Animal Products Many people claim to need animal products to feel good and perform well. In my experience, this assertion generally comes from individuals who felt worse during the first couple of weeks after a change to a lower-animal-source diet. Instead of being patient, they simply returned to their old way of eating—genuinely feeling better for it—and now insist that they need meat to thrive. A diet heavily burdened with animal products places a huge stress on the detoxification systems of the body. As with stopping caffeine and cigarettes, many people observe withdrawal symptoms for a short period, usually including fatigue, weakness, headaches, or loose stools. In 95 percent of such cases, these symptoms resolve within two weeks. It is more common that the temporary adjustment period, during which you might feel mild symptoms as your body withdraws from your prior toxic habits, lasts less than a week. Unfortunately, many people mistakenly assume these symptoms to be due to some lack in the new diet and go back to eating a poor diet again. Sometimes they have been convinced that they feel bad because they aren’t eating enough protein, especially since when they return to their old diet they feel better again. People often confuse feeling well with getting well, not realizing that sometimes you have to temporarily feel a little worse to really get well.

Can a reasonable man ever truly question the nobility of the heat engine he calls his body? What option does he have but to heap praise on his form, to self-adore, to admire, and to hold it up as the greatest statement of beauty in a beautiful garden? What, though, is to be admired in such a frighteningly fragile machine; a perilously needy contraption laced with kilometres of liquid and electrical conduits prone to leaks, rot, clogs, and short-circuits? What is there to be proud of in a machine that has an eight hour battery life and is predetermined to spend half its existence in a defenceless, catatonic coma? What is to be revered in a mechanism let loose in a sealed off room where almost everything—including its single source of light and warmth—makes it sick, but whose immune system functions by late entry crisis-response imitation? Where is the awe in a contrivance that freezes and dies if placed a little over here, or overheats and dies if placed a little over there? Where is the wonder in an instrument that is crushed to a pulp if dropped a little down there, or boiled away to nothing if lifted a little up there? Where is the marvel in an appliance where three-quarters of the planet’s surface will drown it, and three-quarters of the atmosphere will asphyxiate it? What is there to be cherished in a machine born innately greedy and so utterly useless that it has to wait three years for its neural networks to hook-up and come online before it even begins to get a hint of who or even what it is, and only then can it start to relearn absolutely everything its forebears had already bothered to learn? Where is the artistry in a thinking engine whose sweetest fuel can only be embezzled from other thinking engines?

Sexual reproduction is thus a costly investment that has to pay for itself in the short run. The details of theory and experiment on this topic are fascinating (see, e.g., Maynard Smith, 1978; Ridley, 1993), but for our purposes a few highlights from the currently front-running theory are most instructive: sex (in vertebrates like us, at least) pays for itself by making our offspring relatively inscrutable to the parasites we endow them with from birth. Parasites have short lifespans compared with their hosts, and typically reproduce many times during their host’s lifetime. Mammals, for instance, are hosts to trillions of parasites. (Yes, right now, no matter how healthy and clean you are, there are trillions of parasites of thousands of different species inhabiting your gut, your blood, your skin, your hair, your mouth, and every other part of your body. They have been rapidly evolving to survive against the onslaught of your defenses since the day you were born.) Before a female can mature to reproductive age, her parasites evolve to fit her better than any glove. (Meanwhile, her immune system evolves to combat them, a standoff—if she is healthy—in an ongoing arms race.) If she gave birth to a clone, her parasites would leap to it and find themselves at home from the outset. They would be already optimized to their new surroundings. If instead she uses sexual reproduction to endow her offspring with a mixed set of genes (half from her mate), many of these genes—or, more directly, their products, in the offspring’s internal defenses—will be alien or cryptic to the ship-jumping parasites. Instead of home sweet home, the parasites will find themselves in terra incognita. This gives the offspring a big head start in the arms race.

It may seem paradoxical to claim that stress, a physiological mechanism vital to life, is a cause of illness. To resolve this apparent contradiction, we must differentiate between acute stress and chronic stress. Acute stress is the immediate, short-term body response to threat. Chronic stress is activation of the stress mechanisms over long periods of time when a person is exposed to stressors that cannot be escaped either because she does not recognize them or because she has no control over them. Discharges of nervous system, hormonal output and immune changes constitute the flight-or-fight reactions that help us survive immediate danger. These biological responses are adaptive in the emergencies for which nature designed them. But the same stress responses, triggered chronically and without resolution, produce harm and even permanent damage. Chronically high cortisol levels destroy tissue. Chronically elevated adrenalin levels raise the blood pressure and damage the heart. There is extensive documentation of the inhibiting effect of chronic stress on the immune system. In one study, the activity of immune cells called natural killer (NK) cells were compared in two groups: spousal caregivers of people with Alzheimer’s disease, and age- and health-matched controls. NK cells are front-line troops in the fight against infections and against cancer, having the capacity to attack invading micro-organisms and to destroy cells with malignant mutations. The NK cell functioning of the caregivers was significantly suppressed, even in those whose spouses had died as long as three years previously. The caregivers who reported lower levels of social support also showed the greatest depression in immune activity — just as the loneliest medical students had the most impaired immune systems under the stress of examinations. Another study of caregivers assessed the efficacy of immunization against influenza. In this study 80 per cent among the non-stressed control group developed immunity against the virus, but only 20 per cent of the Alzheimer caregivers were able to do so. The stress of unremitting caregiving inhibited the immune system and left people susceptible to influenza. Research has also shown stress-related delays in tissue repair. The wounds of Alzheimer caregivers took an average of nine days longer to heal than those of controls. Higher levels of stress cause higher cortisol output via the HPA axis, and cortisol inhibits the activity of the inflammatory cells involved in wound healing. Dental students had a wound deliberately inflicted on their hard palates while they were facing immunology exams and again during vacation. In all of them the wound healed more quickly in the summer. Under stress, their white blood cells produced less of a substance essential to healing. The oft-observed relationship between stress, impaired immunity and illness has given rise to the concept of “diseases of adaptation,” a phrase of Hans Selye’s. The flight-or-fight response, it is argued, was indispensable in an era when early human beings had to confront a natural world of predators and other dangers. In civilized society, however, the flight-fight reaction is triggered in situations where it is neither necessary nor helpful, since we no longer face the same mortal threats to existence. The body’s physiological stress mechanisms are often triggered inappropriately, leading to disease. There is another way to look at it. The flight-or-fight alarm reaction exists today for the same purpose evolution originally assigned to it: to enable us to survive. What has happened is that we have lost touch with the gut feelings designed to be our warning system. The body mounts a stress response, but the mind is unaware of the threat. We keep ourselves in physiologically stressful situations, with only a dim awareness of distress or no awareness at all.

The Western medical model — and I don't mean the science of it, I mean the practice of it, because the science is completely at odds with the practice — makes two devastating separations. First of all we separate the mind from the body, we separate the emotions from the physiology. So we don't see how the physiology of people reflects their lifelong emotional experience. So we separate the mind from the body, which is not something that traditional medicine has done, I mean, Ayuverdic or Chinese medicine or shamanic tribal cultures and medicinal practices throughout the world have always recognized that mind and body are inseparable. They intuitively knew it. Many Western practitioners have known this and even taught it, but in practice we ignore it. And then we separate the individual from the environment. The studies are clear, for example, that when people are emotionally isolated they tend to get sick more quickly and they succumb more rapidly to their disease. Why? Because people's physiology is completely related to their psychological, social environment and when people are isolated and alone their stress levels are much higher because there's nothing there to help them moderate their stress. And physiologically it is straightforward, you know, it takes a five-year-old kid to understand it. However because in practice we separate them... when somebody shows up with an inflamed joint, all we do is we give them an anti-inflammatory or because the immune system is hyperactive and is attacking them we give them a medication to suppress their immune system or we give them a stress hormone like cortisol or one of its analogues, to suppress the inflammation. But we never ask: "What does this manifest about your life?", "What does this say about your relationships?", "How stressful is your job?", "To what extent do you lack control in your life?", "Where are you not authentic?", "How are you trying to work so hard to meet your attachment needs by suppressing yourself?" (because that is what you learn to do as a kid). Then we do all this research that has to do with cell biology, so we keep looking for the cause of cancer in the cell. Now there's a wonderful quote in the New York Times a couple of years ago they did a series on cancer and somebody said: "Looking for the cause of cancer inside the individual cell is like trying to understand a traffic jam by studying the internal combustion engine." We will never understand it, but we spend hundreds of billions of dollars a year looking for the cause of cancer inside the cell, not recognizing that the cell exists in interaction with the environment and that the genes are modulated by the environment, they are turned on and off by the environment. So the impact of not understanding the unity of emotions and physiology on one hand and in the other hand the relationship between the individual and the environment.. in other words.. having a strictly biological model as opposed to what has been called a bio-psycho-social, that recognizes that the biology is important, but it also reflects our psychological and social relationships. And therefore trying to understand the biology in isolation from the psychological and social environment is futile. The result is that we are treating people purely through pharmaceuticals or physical interventions, greatly to the profit of companies that manufacture pharmaceuticals and which fund the research, but it leaves us very much in the dark about a) the causes and b) the treatment, the holistic treatment of most conditions. So that for all our amazing interventions and technological marvels, we are still far short of doing what we could do, were we more mindful of that unity. So the consequences are devastating economically, they are devastating emotionally, they are devastating medically.

It earns its keep. As it digests HMOs, B. infantis releases short-chain fatty acids (SCFAs) that feed an infant's gut cells - so while mothers nourish this microbe, the microbe in turn nourishes the baby. Through direct contact, B. Infantis also encourages gut cells to make adhesive proteins that seal the gaps between them, and anti-inflammatory molecules that calibrate the immune system. These changes only happen when B. infantis grows on HMOs; if it gets lactose instead, it survives but doesn't engage in any repartee with the baby's cells. It unlocks its full beneficial potential only when it feeds on breast milk. Likewise, for a child to reap the full benefits that milk can provide, B. infantis must be present. For that reason, David Mills, a microbiologist who works with German, actually sees B. infantis as part of milk, albeit a part that is not made in the breast.

We now know that when bacteria break down fibre, they produce chemicals called short chain fatty acids (SCFAs); these trigger an influx of anti-inflammatory cells that bring a boiling immune system back down to a calm simmer. Without fibre, we dial our immunostats to higher settings, predisposing us to inflammatory disease. To make matters worse, when fibre is absent, our starving bacteria react by devouring whatever else they can find-including the mucus layer that covers the gut. As the layer disappears, bacteria get closer to the gut lining itself, where they can trigger responses from the immune cells underneath. And without the restraining influence of the SCFAs, those responses can easily build to extreme proportions.

Two hormones, leptin and ghrelin, are secreted in a natural biorhythm. When the stomach is empty, its cells secrete ghrelin, sending a message to the brain that you register as feeling hungry. When you’ve had enough to eat, that’s the result of a message from leptin, secreted by fat cells, which balances the hunger-satiation rhythm. In fact, obesity and leptin have both been implicated in risk for Alzheimer’s disease. Epidemiological (i.e., population) studies have shown higher circulating leptin levels to be associated with lower risk of Alzheimer’s, while lower circulating levels of leptin have been found in patients already suffering from the disease. Leptin receptors are highly expressed in the hippocampus, the area of the brain responsible for short-term memory, which is ravaged by Alzheimer’s. Leptin supplementation actually led to less Alzheimer’s pathology in this brain region in mouse studies of the disease. This is yet further evidence strengthening the link between the gut and the brain.

In short, there is good reason to believe that asthma and other allergies are mismatch diseases in which too little exposure to microorganisms contribute to an imbalance that, paradoxically, causes too much of a response to otherwise harmless foreign substances. The immune system, however, is far more complex than the above description, and there is no question that other factors—many of them genetic—also play key roles. Twins, for example, are more likely than not to share the same allergy.

Southerners have a sense of perspective, a way of finding the humor in even the most painful of experiences. We know that life is too short to be unhappy. Even when we’re lower than lizard spit (as Florida Grits Sandra Presley often says), we find a smile. The best way to know Southern humor is to hear it. The best way to hear it is to come on down South. But please don’t come empty-handed. Bring a joke; get a joke. You know what I mean, Vern? Southerners have always known that laughter is good for you. We’d been laughing at ourselves for many years before research proved that laughter reduces stress, decreases pain, increases energy, inspires creativity, and helps relationships grow. These benefits boost the immune system and strengthen our hearts and lungs. No wonder Southerners are the happiest people around!

Our immune system does not exist in isolation from daily experience. For example, the immune defences that normally function in healthy young people have been shown to be suppressed in medical students under the pressure of final examinations. Of even greater implication for their future health and well-being, the loneliest students suffered the greatest negative impact on their immune systems. Loneliness has been similarly associated with diminished immune activity in a group of psychiatric inpatients. Even if no further research evidence existed—though there is plenty—one would have to consider the long-term effects of chronic stress. The pressure of examinations is obvious and short term, but many people unwittingly spend their entire lives as if under the gaze of a powerful and judgmental examiner whom they must please at all costs. Many of us live, if not alone, then in emotionally inadequate relationships that do not recognize or honour our deepest needs. Isolation and stress affect many who may believe their lives are quite satisfactory. How may stress be transmuted into illness? Stress is a complicated cascade of physical and biochemical responses to powerful emotional stimuli. Physiologically, emotions are themselves electrical, chemical and hormonal discharges of the human nervous system. Emotions influence—and are influenced by—the functioning of our major organs, the integrity of our immune defences and the workings of the many circulating biological substances that help govern the body’s physical states. When emotions are repressed, this inhibition disarms the body’s defences against illness. Repression—dissociating emotions from awareness and relegating them to the unconscious realm—disorganizes and confuses our physiological defences so that in some people these defences go awry, becoming the destroyers of health rather than its protectors.

All winter she has struggled to describe the joy of her life’s work and the discoveries that have solidified in a few short years: how trees talk to one another, over the air and underground. How they care and feed each other, orchestrating shared behaviors through the networked soil. How they build immune systems as wide as a forest. She spends a chapter detailing how a dead log gives life to countless other species. Remove the snag and kill the woodpecker who keeps in check the weevils that would kill the other trees. She describes the drupes and racemes, panicles and involucres that a person could walk past for a lifetime and never notice. She tells how the woody-coned alders harvest gold. How an inch-high pecan might have six feet of root. How the inner bark of birches can feed the starving. How one hop hornbeam catkin holds several million grains of pollen. How indigenous fishermen use crushed walnut leaves to stun and catch fish. How poplars clean soils of chlorinated solvents and willows remove heavy metals. She lays out how fungal hyphae—countless miles of filaments folded up in every spoon of soil—coax open tree roots and tap into them. How the wired-up fungi feed the tree minerals. How the tree pays for these nutrients with sugars, which the fungi can’t make.

The ancient counter will even shut down your immune system, expending the energy and resources required for future health now, during the crises of the present. It will render you impulsive,20 so that you will jump, for example, at any short-term mating opportunities, or any possibilities of pleasure, no matter how sub-par, disgraceful or illegal.

Naturally, immunity is a natural physician that fends off all invading bacteria and viruses, whereas food becomes its medicine or trouble since that appears to increase or decrease your immune system; thus, choose the right and healthy food, and adopt this proverb: Eat to be alive, not live to eat. Experienced and qualified doctors understand the side effects of medicines before the prescription. Indeed, the majority of doctors hold a professional degree and certificate, whereas virtually none of them has the latest and accurate knowledge; as a result, it executes no difference between such doctors and a robot. When naturopathy experts and spiritual figures predict with significant certainty that you have no cancer or whatever other sickness, it confuses, surprises, and creates suspicious feelings in your mind, whereas doctors have diagnosed metastatic cancer. What should one believe and what not? However, one’s enemies are still awaiting its death. One breathes, expecting and waiting for the miracle of God; it will soon happen if one believes. You neither feel trust in your family doctor and specialists nor feel satisfaction with their treatment. You always realize that they do not tell the truth about how risky your disease is, and they never discuss it. If doctors fail to meet your sufferings of mucus, shortness of breath, and swallowing difficulties because of medication’s side effects, they will indeed put you on medical victimization, ignoring the better quality of life that the medical system promises. Most doctors work for the insurance companies instead of caring for patients. It is factually a medical crime that doctors, hospitals, or insurance providers put patients at high risk. Many doctors do not respect patients’ requests to fulfill it because patients want treatment according to international medical guidelines. Such refusal results in the spreading of their suffering. It saddens patients that the doctors only think about the insurance provider and not the patient. Indeed, such a situation can put one on the track in a dilemma. However, one’s experience and others may prove that none of the medicines give patients a good quality of life, whether homeopathy, allopathy, naturopathy, or even a spiritual one. If your fate stands as a barrier in front of you, no one sees or realizes what you have faced and is still facing worries about your health. Factually, robot doctors cannot provide significant information that may help to ease patients’ suffering; there is only one way to change lifestyle and stay strict on diet; it will have a better result than medicine, which is full of toxins that damage patients’ health instead of curing it. One can think or predict that the medical world has become a medical trade in which one cannot exclude the medical mafia. Is it a valid context that requires an authentic answer?

If you’re like most people, a string of nerve-racking incidents keeps you in fight-or-flight response—and out of homeostasis—a large part of the time. Maybe the car cutting you off is the only actual life-threatening situation you encounter all day, but the traffic on the way to work, the pressure of preparing for a big presentation, the argument you had with your spouse, the credit-card bill that came in the mail, the crashing of your computer hard drive, and the new gray hair you noticed in the mirror keep the stress hormones circulating in your body on a near-constant basis. Between remembering stressful experiences from the past and anticipating stressful situations coming up in your future, all these repetitive short-term stresses blur together into long-term stress. Welcome to the 21st-century version of living in survival mode. In fight-or-flight mode, life-sustaining energy is mobilized so that the body can either run or fight. But when there isn’t a return to homeostasis (because you keep perceiving a threat), vital energy is lost in the system. You have less energy in your internal environment for cell growth and repair, long-term building projects on a cellular level, and healing when that energy is being channeled elsewhere. The cells shut down, they no longer communicate with one another, and they become “selfish.” It’s not time for routine maintenance (let alone for making improvements); it’s time for defense. It’s every cell for itself, so the collective community of cells working together becomes fractured. The immune and endocrine systems (among others) become weakened as genes in those related cells are compromised when informational signals from outside the cells are turned off. It’s like living in a country where 98 percent of the resources go toward defense, and nothing is left for schools, libraries, road building and repair, communication systems, growing of food, and so on. Roads develop potholes that aren’t fixed. Schools suffer budget cuts, so students wind up learning less. Social welfare programs that took care of the poor and the elderly have to close down. And there’s not enough food to feed the masses. Not surprisingly, then, long-term stress has been linked to anxiety, depression, digestive problems, memory loss, insomnia, hypertension, heart disease, strokes, cancer, ulcers, rheumatoid arthritis, colds, flu, aging acceleration, allergies, body pain, chronic fatigue, infertility, impotence, asthma, hormonal issues, skin rashes, hair loss, muscle spasms, and diabetes, to name just a few conditions (all of which, by the way, are the result of epigenetic changes). No organism in nature is designed to withstand the effects of long-term stress.

Physical effects, both long and short term, include: Racing heart, headache, nausea, muscle tension, fatigue, dry mouth, dizzy feelings, increase in breathing rate, aching muscles, trembling and twitching, sweating, disturbed digestion, immune system suppression and memory issues. Your body was designed to endure brief moments of acute stress, but chronic stress (stress that is ongoing) can start to cause chronic health conditions, like cardiovascular disease, insomnia, hormonal dysregulation and so on. If the ordinary physical experience of stress is prolonged, the physical effects can have consequences in the rest of your life… Mental and psychological effects include: Exhaustion and fatigue, feeling on edge, nervousness, irritability, inability to concentrate, lack of motivation, changes to libido and appetite, nightmares, depression, feeling out of control, apathy and so on. Stress can reinforce negative thinking patterns and harmful self-talk, lower our confidence, and kill our motivation. More alarming than this, overthinking can completely warp your perception of events in time, shaping your personality in ways that mean you are more risk averse, more negatively focused and less resilient. When you’re constantly tuned into Stress FM you are not actually consciously aware and available in the present moment to experience life as it is. You miss out on countless potential feelings of joy, gratitude, connection and creativity because of your relentless focus on what could go wrong, or what has gone wrong. This means you’re less likely to recognize creative solutions to problems, see new opportunities and capitalize on them, or truly appreciate all the things that are going right for you. If you are constantly in a low-level state of fear and worry, every new encounter is going to be interpreted through that filter, and interpreted not for what it is, but for what you’re worried it could be.  Broader social and environmental effects include: Damage to close relationships, poor performance at work, impatience and irritability with others, retreating socially, and engaging in addictive or harmful behaviors. A person who is constantly stressed and anxious starts to lose all meaning and joy in life, stops making plans, cannot act with charity or compassion to others, and loses their passion for life. There is very little spontaneity, humor or irreverence when someone’s mind is too busy catastrophizing, right? As you can imagine, the physical, mental and environmental aspects all interact to create one, unified experience of overthinking and anxiety. For example, if you overthink consistently, your body will be flooded with cortisol and other stress hormones. This can leave you on edge, and in fact cause you to overthink even more, adding to the stress, changing the way you feel about yourself and your life. You might then make bad choices for yourself (staying up late, eating bad food, shutting people out) which reinforce the stress cycle you’re in. You may perform worse at work, procrastinating and inevitably giving yourself more to worry about, and so on…

The following are all foods you should feel welcome to eat freely (unless, of course, you know they bother your stomach): Alliums (Onions, Leeks, Garlic, Scallions): This category of foods, in particular, is an excellent source of prebiotics and can be extremely nourishing to our bugs. If you thought certain foods were lacking in flavor, try sautéing what you think of as that “boring” vegetable or tofu with any member of this family and witness the makeover. Good-quality olive oil, sesame oil, or coconut oil can all help with the transformation of taste. *Beans, Legumes, and Pulses: This family of foods is one of the easiest ways to get a high amount of fiber in a small amount of food. You know how beans make some folks a little gassy? That’s a by-product of our bacterial buddies chowing down on that chili you just consumed for dinner. Don’t get stuck in a bean rut. Seek out your bean aisle or peruse the bulk bin at your local grocery store and see if you can try for three different types of beans each week. Great northern, anyone? Brightly Colored Fruits and Vegetables: Not only do these gems provide fiber, but they are also filled with polyphenols that increase diversity in the gut and offer anti-inflammatory compounds that are essential for disease prevention and healing. Please note that white and brown are colors in this category—hello, cauliflower, daikon radish, and mushrooms! Good fungi are particularly anti-inflammatory, rich in beta-glucans, and a good source of the immune-supportive vitamin D. Remember that variety is key here. Just because broccoli gets a special place in the world of superfoods doesn’t mean that you should eat only broccoli. Branch out: How about trying bok choy, napa cabbage, or an orange pepper? Include a spectrum of color on your plate and make sure that some of these vegetables are periodically eaten raw or lightly steamed, which may have greater benefits to your microbiome. Herbs and Spices: Not only incredibly rich in those anti-inflammatory polyphenols, this category of foods also has natural digestive-aid properties that can help improve the digestibility of certain foods like beans. They can also stimulate the production of bile, an essential part of our body’s mode of breaking down fat. Plus, they add pizzazz to any meal. Nuts, Seeds, and Their Respective Butters: This family of foods provides fiber, and it is also a good source of healthy and anti-inflammatory fats that help keep the digestive tract balanced and nourished. It’s time to step out of that almond rut and seek out new nutty experiences. Walnuts have been shown to confer excellent benefits on the microbiome because of their high omega-3 and polyphenol content. And if you haven’t tasted a buttery hemp seed, also rich in omega-3s and fantastic atop oatmeal, here’s your opportunity. Starchy Vegetables: These hearty vegetables are a great source of fiber and beneficial plant chemicals. When slightly cooled, they are also a source of something called resistant starch, which feeds the bacteria and enables them to create those fantabulous short-chain fatty acids. These include foods like potatoes, winter squash, and root vegetables like parsnips, beets, and rutabaga. When was the last time you munched on rutabaga? This might be your chance! Teas: This can be green, white, or black tea, all of which contain healthy anti-inflammatory compounds that are beneficial for our microbes and overall gut health. It can also be herbal tea, which is an easy way to add overall health-supportive nutrients to our diet without a lot of additional burden on our digestive system. Unprocessed Whole Grains: These are wonderful complex carbohydrates (meaning fiber-filled), which both nourish those gut bugs and have numerous vitamins and minerals that support our health. Branch out and try some new ones like millet, buckwheat, and amaranth. FOODS TO EAT IN MODERATION

If your long path is short-circuited by stress, and your brain is using the short path instead, you might be so alarmed at the mere thought of a shark that you have a panic attack just thinking about taking a swim in the ocean. All the body’s machinery of FFF then gets engaged by this imaginary threat, just as if you were nose to nose with Jaws. Your gut clenches, your heart races, your breathing becomes fast and shallow, and your focus narrows to the point where you can’t think about anything other than the threat. This takes a huge biological toll on the body. High adrenaline produces dramatic reductions in life span. Stressed people have much more disease and live much shorter lives than unstressed people. Whatever form stress takes—depression, anxiety, or PTSD—correlates with higher rates of cancer, diabetes, and heart disease. The deficits in the life spans of stressed people are measured in decades rather than years. In meditators, the amygdala is quiet. It becomes even quieter with practice. The difference in amygdala activation between the longest-term meditators and their less-experienced peers has been measured. The adepts show 400% less reactivity to stressful events. But even in novices who practice mindfulness for 30 hours over 8 weeks, decreased amygdala activity is found. Other structures within the midbrain or limbic system work together with the hippocampus and amygdala. One of them, the thalamus, is like a relay station. Close to the corpus callosum, it identifies information coming in from the senses like touch, hearing, and taste, and directs it to the consciousness centers of the prefrontal cortex. The thalamus typically becomes more active during meditation, as it works harder to suppress sensory input (like “that buzzing mosquito” or “this chair is too hard”) that pulls us out of Bliss Brain. With the hippocampus regulating emotion, the thalamus regulating sensory input, and the long path in good working order, stress-inducing signals aren’t sent to the amygdala. In turn, all the body’s FFF machinery remains offline. This produces corresponding biological benefits. Heart rhythm is even. Respiration is deep and slow. Digestion is effective. Immunity is high. That’s why so many studies show pervasive health and longevity benefits among meditators.

THERE WAS ONE MAN in the movie business immune to the usual pressures of dealing with actors, directors, set design, and union contractors. He created stars who never aged, never complained, never walked off the job, and never demanded salaries. By 1937 Walt Disney was already a dominant parallel force to the studio system, “the Horatio Alger hero of Cinema.” He did need distribution, but his company’s work had such a strong draw at the box office that the distribution arms needed Disney more than the other way around. He controlled the biggest star in the world, Mickey Mouse, who had debuted in a short seven-minute cartoon Steamboat Willie in 1928. Even better, Mickey was a commercial phenomenon away from the box office.

As we have learned, the immune system stimulates inflammation to defend us from pathogens as well as self-inflicted damage caused by physical activity. In short bursts, inflammation is lifesaving, but low levels of inflammation that last for months or years are pernicious because they slowly attack our bodies. Over time, the destructive effects of chronic, simmering inflammation accumulate in cells and tissues from head to toe including neurons in the brain, cartilage in joints, the walls of arteries, and insulin receptors in muscle and fat cells. If oxidation, mitochondrial dysfunction, mutations, glycation, and inflammation were not enough, plenty of other processes also contribute to senescence by damaging and degrading cells. Over time, tiny molecules glue themselves to the DNA in cells. These so-called epigenetic (on top of the genome) modifications can affect which genes are expressed in particular cells.31 Because environmental factors like diet, stress, and exercise partly influence epigenetic modifications, the older we are, the more of them we accumulate.32 Most epigenetic modifications are harmless, but the more you have for a given age, the higher your risk of dying.33 Other forms of senescence include cells losing the ability to recycle damaged proteins,34 inadequately sensing and acquiring nutrients,35 and (less likely) being unable to divide because the little caps (telomeres) that protect the ends of chromosomes from unraveling have become too short.36

Routinely sleeping less than six or seven hours a night demolishes your immune system, more than doubling your risk of cancer. Insufficient sleep is a key lifestyle factor determining whether or not you will develop Alzheimer’s disease. Inadequate sleep—even moderate reductions for just one week—disrupts blood sugar levels so profoundly that you would be classified as pre-diabetic. Short sleeping increases the likelihood of your coronary arteries becoming blocked and brittle, setting you on a path toward cardiovascular disease, stroke, and congestive heart failure. Fitting Charlotte Brontë’s prophetic wisdom that “a ruffled mind makes a restless pillow,” sleep disruption further contributes to all major psychiatric conditions, including depression, anxiety, and suicidality.

Routinely sleeping less than six or seven hours a night demolishes your immune system, more than doubling your risk of cancer. Insufficient sleep is a key lifestyle factor determining whether or not you will develop Alzheimer’s disease. Inadequate sleep—even moderate reductions for just one week—disrupts blood sugar levels so profoundly that you would be classified as pre-diabetic. Short sleeping increases the likelihood of your coronary arteries becoming blocked and brittle, setting you on a path toward cardiovascular disease, stroke, and congestive heart failure.

GUIDELINE #9: TAKE CARE OF YOUR HEALTH. Being targeted by a predator, even or especially a human one, evokes the fight-or-flight response in animals and in people. This essentially adaptive response is intended by nature to be short-lived—the animal either flees or makes a stand against the predator, both actions requiring all of the body’s systems on alert to ensure survival. But when the predation is carried out over a long period of time, as is often the case in sociopathy, the physiological components of the fight-or-flight response become protracted: blood pressure and heart rate increase and remain high; stored reserves of fats and sugars are continually converted and released into the bloodstream (to supply extra energy to fight or run); muscles all over the body are tense; digestion slows and stomach acidity increases; slow and relaxed diaphragmatic breathing changes to fast and shallow chest breathing; and, beginning in the hypothalamus, a persistent chain of hormonal reactions stimulates the adrenal cortex to release unhealthily large quantities of stress hormones such as cortisol. For a while the body will attempt to adapt, but if it continues to be stressed, it will eventually succumb to exhaustion, immune system depletion, and illness. In other words, being targeted by a sociopath can make you very sick in the long run.

Shortly after Dave was diagnosed with leish, Tom Weinberg learned from the CDC that he, too, had the disease. Chris Fisher, Mark Adams, and Juan Carlos Fernández went to the NIH and were also diagnosed with it. All were treated except Juan Carlos; Dr. Nash recognized that his immune system appeared to be fighting it off and decided to delay treatment. It was the right decision, and Juan Carlos ended up leish-free without going through the rigors of amphotericin B.

Routinely sleeping less than six hours a night weakens your immune system, substantially increasing your risk of certain forms of cancer. Insufficient sleep appears to be a key lifestyle factor linked to your risk of developing Alzheimer’s disease. Inadequate sleep—even moderate reductions for just one week—disrupts blood sugar levels so profoundly that you would be classified as pre-diabetic. Short sleeping increases the likelihood of your coronary arteries becoming blocked and brittle, setting you on a path toward cardiovascular disease, stroke, and congestive heart failure.

A Lasting Legacy I return to Elkins now, to make a summary point and a single closing observation. The summary point is that even as a closed system, slavery, simply because of its long duration, produced over time a distinctive African American culture. This is a point stressed in Eugene Genovese’s Roll, Jordan, Roll and in his mostly sympathetic critique of Elkins. Slaves, for instance, developed a repertoire of songs and stories and relationships—sometimes lifelong relationships—that ultimately helped to form a black identity in the United States. There is no analog for this in the concentration camps, partly because of the nature of the camps and partly because they lasted for just a dozen years from 1933 to 1945. In general, camp prisoners did not form close relationships, partly because this was discouraged by the guards and partly because prisoners realized that the very person you befriended last week could be summarily executed this week. So the only behavioral changes that concentration camps produced were in the nature of short-term adaptations to camp life itself. It follows from this that the cultural legacy of slavery long outlasted slavery while the cultural legacy of the camps—including the peculiar disfigurations of personality that Elkins detected—proved to be a temporary phenomenon. The phenomena of the zombie-like Muselmanner, the ersatz Nazism of the Kapos—all of this is now gone. It makes no sense to say that Jews or eastern Europeans today display any of the characteristics that developed within that temporary closed system. With American blacks, however, the situation is quite different. Although slavery ended in 1865, it lasted more than 200 years, and it had its widest scope during the era of Democratic supremacy in the South from the 1820s through the 1860s. Many of the features of the old slave plantation—dilapidated housing, broken families, a high degree of violence required to keep the place together, a paucity of opportunity and advancement prospects, a widespread sense of nihilism and despair—are evident in Democrat-run inner cities like Oakland, Detroit, Baltimore, and Chicago. “There was a distinct underclass of slaves,” political scientist Orlando Patterson writes, “who lived fecklessly or dangerously. They were the incorrigible blacks of whom the slave-owner class was forever complaining. They ran away. They were idle. They were compulsive liars. They seemed immune to punishment.” And then comes Patterson’s punch line: “We can trace the underclass, as a persisting social phenomenon, to this group.” 39 The Left doesn’t like Patterson because he’s a black scholar of West Indian origin with a penchant for uttering politically incorrect truths.

Symptoms of a sickness are not necessarily signs of weakness, rather they imply that your body is actively fighting the sickness. And when all the resources of the body fall short to fight the sickness, that's when the real trouble begins.

Most people today live in relatively constant distress and anxiety. This is related to a low-grade but perpetual fight-or-flight response masterminded by the Judge in reaction to the challenges of life, both personal and professional. Though the fight-or-flight response originally evolved to get us out of acute, short-term danger, most of us run the Survivor Brain continuously. The consequence of this perpetual stress and anxiety is heightened blood pressure, increased cardiovascular disease, reduced immune system function, reduced longevity, and reduced happiness and performance.

In short, when things get tough, our bodies produce a stress hormone called cortisol, which is supposed to help mobilize our energy reserves and temporarily suppress the immune system during times of stress. However, excessive cortisol production brought on by that rough first half—whether that looks like ongoing financial worries, relationship problems, work-related stress, poor sleep, a business plan that is falling apart, or that teenager who is pushing our last buttons—can result in a range of negative health effects, making us feel anxious and frustrated.13 This can make any task seem even harder, pushing us to quit to get some relief.