Human Physiology Quotes

The discovery of a new dish does more for the happiness of the human race than the discovery of a star.

If we wish to know about a man, we ask 'what is his story--his real, inmost story?'--for each of us is a biography, a story. Each of us is a singular narrative, which is constructed, continually, unconsciously, by, through, and in us--through our perceptions, our feelings, our thoughts, our actions; and, not least, our discourse, our spoken narrations. Biologically, physiologically, we are not so different from each other; historically, as narratives--we are each of us unique.

On the surface, I was calm: in secret, without really admitting it, I was waiting for something. Her return? How could I have been waiting for that? We all know that we are material creatures, subject to the laws of physiology and physics, and not even the power of all our feelings combined can defeat those laws. All we can do is detest them. The age-old faith of lovers and poets in the power of love, stronger than death, that finis vitae sed non amoris, is a lie, useless and not even funny. So must one be resigned to being a clock that measures the passage of time, now out of order, now repaired, and whose mechanism generates despair and love as soon as its maker sets it going? Are we to grow used to the idea that every man relives ancient torments, which are all the more profound because they grow comic with repetition? That human existence should repeat itself, well and good, but that it should repeat itself like a hackneyed tune, or a record a drunkard keeps playing as he feeds coins into the jukebox... Must I go on living here then, among the objects we both had touched, in the air she had breathed? In the name of what? In the hope of her return? I hoped for nothing. And yet I lived in expectation. Since she had gone, that was all that remained. I did not know what achievements, what mockery, even what tortures still awaited me. I knew nothing, and I persisted in the faith that the time of cruel miracles was not past.

The brain-disease model overlooks four fundamental truths: (1) our capacity to destroy one another is matched by our capacity to heal one another. Restoring relationships and community is central to restoring well-being; (2) language gives us the power to change ourselves and others by communicating our experiences, helping us to define what we know, and finding a common sense of meaning; (3) we have the ability to regulate our own physiology, including some of the so-called involuntary functions of the body and brain, through such basic activities as breathing, moving, and touching; and (4) we can change social conditions to create environments in which children and adults can feel safe and where they can thrive. When we ignore these quintessential dimensions of humanity, we deprive people of ways to heal from trauma and restore their autonomy. Being a patient, rather than a participant in one’s healing process, separates suffering people from their community and alienates them from an inner sense of self.

Humanity is a biological species, living in a biological environment, because like all species, we are exquisitely adapted in everything: from our behavior, to our genetics, to our physiology, to that particular environment in which we live. The earth is our home. Unless we preserve the rest of life, as a sacred duty, we will be endangering ourselves by destroying the home in which we evolved, and on which we completely depend.

We all want expanded consciousness and bliss. It's a natural, human desire. And a lot of people look for it in drugs. But the problem is that the body, the physiology, takes a hard hit on drugs. Drugs injure the nervous system, so they just make it harder to get those experiences on your own. I have smoked marijuana, but I no longer do. I went to art school in the 1960s, so you can imagine what was going on. Yet my friends were the ones who said, "No, no, no, David, don't you take those drugs." I was pretty lucky. Besides, far more profound experiences are available naturally. When your consciousness stars expanding, those experiences are there. All those things can be seen. It's just a matter of expanding that ball of consciousness. And the ball of consciousness can expand to be infinite and unbounded. It's totality. You can have totality. So all those experiences are there for you, without the side effects of drugs.

It takes the average human seven minutes to go to sleep, but according to Hand’s Human Physiology, it takes the same average human fifteen to twenty minutes to wake up.

For her, sex was nothing more than an itch. And this phsychological and physiological neutrality of hers at once relieved her of so many human emotions and sentiments and desires. Sexual neutrality was the essence of coldness in an individual. It was a great and wonderful thing to be born with.

The salient stressors in the lives of most human beings today — at least in the industrialized world — are emotional. Just like laboratory animals unable to escape, people find themselves trapped in lifestyles and emotional patterns inimical to their health. The higher the level of economic development, it seems, the more anaesthetized we have become to our emotional realities. We no longer sense what is happening in our bodies and cannot therefore act in self-preserving ways. The physiology of stress eats away at our bodies not because it has outlived its usefulness but because we may no longer have the competence to recognize its signals.

Ketones are an efficient and effective fuel for human physiology without increasing the production of damaging free radicals. Ketosis allows a person to experience nonfluctuating energy throughout the day as well as enhanced brain function and possibly resistance to malignancy. – Dr. David Perlmutter

But if we reason it out simply and not try to be one bit fancy, then what sort of pride can you possibly take or what's the sense of ever having it, if man is poorly put together as a physiological type and if the enormous majority of the human race is brutal, stupid, and profoundly unhappy?

Each of us is aware he's a material being, subject to the laws of physiology and physics, and that the strength of all our emotions combined cannot counteract those laws. It can only hate them. The eternal belief of lovers and poets in the power of love which is more enduring that death, the finis vitae sed non amoris that has pursued us through the centuries is a lie. But this lie is not ridiculous, it's simply futile. To be a clock on the other hand, measuring the passage of time, one that is smashed and rebuilt over and again, one in whose mechanism despair and love are set in motion by the watchmaker along with the first movements of the cogs. To know one is a repeater of suffering felt ever more deeply as it becomes increasingly comical through a multiple repetitions. To replay human existence - fine. But to replay it in the way a drunk replays a corny tune pushing coins over and over into the jukebox?

Difficulty staying well regulated emotionally and physiologically should be a core, defining feature of autism. Unfortunately professionals have long overlooked this, focusing on the resulting behaviors instead of the underlying causes.

Hormones and neurotransmitters, the chemicals associated with human desire, fear, love, joy, and sadness, “are highly conserved across taxa,” Jennifer said. This means that whether you’re a person or a monkey, a bird or a turtle, an octopus or a clam, the physiological changes that accompany our deepest-felt emotions appear to be the same. Even a brainless scallop’s little heart beats faster when the mollusk is approached by a predator, just like yours or mine would do were we to be accosted by a mugger.

Were they normal? What a question to ask! And it is always those who know nothing about human nature, who are bored by psychology and shocked by physiology, who ask it.

Of the human form especially it is so great it must never be made ridiculous. . . Exaggerations will be revenged in human physiology.

In other cases the challenge is to appreciate how, though human physiology resembles that of other species, we use the physiology in novel ways.

Of the human form especially, it is so great it must never be made ridiculous . . . Exaggerations will be revenged in human physiology.

Headache, hmm?" His expression went serious. "Do you know what's the best cure for that?" "What?" "Orgasm." He said it so matter-of-factly I had to sputter a laugh. "Multiple, if possible," he continued. "It's a proven medical fact that one physiologic event, like orgasm, can cancel out the effects of another physiological process, such as a headache." His expression was perfectly serious, but I said, "You're full of shit." "Perhaps. If so, you should call my bluff. Just open the door and we'll test it out.

Playing nice" comes naturally when our neuroception detects safety and promotes physiological states that support social behavior. However, pro-social behavior will not occur when our neuroception misreads the environmental cues and triggers physiological states that support defensive strategies. After all, "playing nice" is not appropriate or adaptive behavior in dangerous or life-threatening situations. In these situations, humans - like other mammals - react with more primitive neurobiological defense systems. To create relationships, humans must subdue these defensive reactions to engage, attach, and form lasting social bonds. Humans have adaptive neurobehavioral systems for both pro-social and defensive behaviors.

The celebrated Parisian doctor Professor Xavier Bichat developed a fully materialist theory of the human body and mind in his lectures Physiological Researches on Life and Death, translated into English in 1816. Bichat defined life bleakly as ‘the sum of the functions by which death is resisted

My wife is pregnant, and her physician told her that physiologically and medically speaking, there are three different kinds of humans: men, women, and pregnant women. I think the same idea applies to you, Edward. There are grown-ups, children, and then you. You don’t feel like a kid anymore, right?” Edward nods. “But you won’t be an adult for years. You’re something else, and we need to figure out what you are, so we can figure out how to help you.

Understanding the physiological and neurological features of spiritual experiences should not be interpreted as an attempt to discredit their reality or explain them away. Rather, it demonstrates their physical existence as a fundamental, shared part of human nature. Spiritual experiences cannot be considered irrational, since we have seen that, given their physiological basis, experiencers' descriptions of them are perfectly rational... All human perceptions of material reality can ultimately be documented as chemical reactions in our neurobiology; all our sensations, thoughts, and memories are ultimately reducible to chemistry, yet we feel no need to deny the existence of the material world; it is not less real because our perceptions of it are biologically based... It is not rational to assume that the spiritual reality of core experiences is any less real than the more scientifically documentable material reality.

The need of one human being for the approval of his fellow humans, the need for a certain cult of fellowship - a psychological, almost physiological need for approval of one's thought and action. A force that kept men from going off at unsocial tangents, a force that made for social security and human solidarity, for the working together of the human family. Men died for that approval, sacrificed for that approval, lived lives they loathed for that approval. For without it man was on his own, an outcast, an animal that had been driven from the pack. It had led to terrible things, of course - to mob psychology, to racial persecution, to mass atrocities in the name of patriotism or religion. But likewise it had been the sizing that held the race together, the thing that from the very start had made human society possible. And Joe didn't have it. Joe didn't give a damn. He didn't care what anyone thought of him. He didn't care whether anyone approved or not.

The dissociation between fear and aggression is evident in violent psychopaths, who are the antithesis of fearful—both physiologically and subjectively they are less reactive to pain; their amygdalae are relatively unresponsive to typical fear-evoking stimuli and are smaller than normal.34 This fits with the picture of psychopathic violence; it is not done in aroused reaction to provocation. Instead, it is purely instrumental, using others as a means to an end with emotionless, remorseless, reptilian indifference.

Humans are built to move. We evolved under conditions that required daily intense physical activity, and even among individuals with lower physical potential, that hard-earned genotype is still ours today. The modern sedentary lifestyle leads to the inactivation of the genes related to physical performance, attributes that were once critical for survival and which are still critical for the correct, healthy expression of the genotype. The genes are still there, they just aren't doing anything because the body is not stressed enough to cause a physiological adaptation requiring their activation. The sedentary person's heart, lungs, muscles, bones, nerves and brain all operate far below the level at which they evolved to function, and at which they still function best.

To me, the best, if not the only function of imaginative writing, is to lead the human imagination outward, to take it into the vast external cosmos, and away from all that introversion and introspection, that morbidly exaggerated prying into one's own vitals—and the vitals of others—which Robinson Jeffers has so aptly symbolized as "incest." What we need is less "human interest," in the narrow sense of the term—not more. Physiological—and even psychological analysis—can be largely left to the writers of scientific monographs on such themes. Fiction, as I see it, is not the place for that sort of grubbing.

If sexual physiology provides the pattern for our experience of the world, what is woman's basic metaphor? It is mystery, the hidden. Karen Horney speaks of a girl's inability to see her genitals and a boy's ability to see his as the source of "the greater subjectivity of women as compared with the greater objectivity of men." To rephrase this with my different emphasis: men's delusional certitude that objectivity is possible is based on the visibility of their genitals. Second, this certitude is a defensive swerve from the anxiety-inducing invisibility of the womb. Women tend to be more realistic and less obsessional because of their toleration for ambiguity which they learn from their inability to learn about their own bodies. Women accept limited knowledge as their natural condition, a great human truth that a man may take a lifetime to reach. The female body’s unbearable hiddenness applies to all aspects men’s dealings with women. What does it look like in there? Did she have an orgasm? Is it really my child? Who was my real father? Mystery surrounds women’s sexuality. This mystery is the main reason for the imprisonment man has imposed on women. Only by confining his wife in a locked harem guarded by eunuchs could he be certain that her son was also his.

Some Greek idiot believed the ring finger on the left hand had an artery that led straight to the heart. And they bought it. How such an intelligent species could be so uninformed about their own physiology for so much of their existence was beyond me. Humans scoffed at the idea of gods and turned their backs on us, leaving us all to die. Yet some ridiculous notion that wearing a chunk of metal on a certain finger bound two souls until death stuck. Figures.

As graduation loomed, I had a nagging sense that there was still far too much unresolved for me, that I wasn’t done studying. I applied for a master’s in English literature at Stanford and was accepted into the program. I had come to see language as an almost supernatural force, existing between people, bringing our brains, shielded in centimeter-thick skulls, into communion. A word meant something only between people, and life’s meaning, its virtue, had something to do with the depth of the relationships we form. It was the relational aspect of humans—i.e., “human relationality”—that undergirded meaning. Yet somehow, this process existed in brains and bodies, subject to their own physiologic imperatives, prone to breaking and failing. There must be a way, I thought, that the language of life as experienced—of passion, of hunger, of love—bore some relationship, however convoluted, to the language of neurons, digestive tracts, and heartbeats.

People who live in big cities are used to the churning sounds of passing cars. But just because we don’t perceive it, doesn’t mean our body isn’t having a physiological response to what’s happening.

A good marriage, where both partners are exclusively committed to each other, keeps them healthier both physiologically and psychologically, by directly influencing the nervous system and immune system.

Whiteness, like race, may not be true—it’s not a biologically heritable characteristic that has roots in physiological structures or in genes or chromosomes. But it is real, in the sense that societies and rights and goods and resources and privileges have been built on its foundation. DiAngelo brilliantly names a whiteness that doesn’t want to be named, disrobes a whiteness that dresses in camouflage as humanity, unmasks a whiteness costumed as American, and fetches to center stage a whiteness that would rather hide in visible invisibility.

It is no coincidence that the greatest changes and innovations in human physiology, cognition, sociality, communication, technology and culture (dwarfing any of today’s inventions and developments) occurred during the Pleistocene.

those who experienced the “Thank God it wasn’t me” response. Having this thought race through your mind upon seeing violent death is arguably one of the deepest, darkest, most shameful of all human responses. However, when you tell people that it is a normal thought, it is as if a huge weight has been lifted, and their sense of shame no longer has power to hurt them.

Are white people only able to talk to me if they’ve trained their minds not to see me as black? Is the only path to acceptance not breaking the fantasy that white people have of everyone’s equality? I’ve never thought I was anything but human. My black womanhood does not cancel out my humanity. These are not facts that repel each other. Physiologically, of course, we are all human. Socially, we dehumanize people of color daily. We judge their clothes, speech, hair, and education level as criteria for whether they have earned the right to be treated with common decency. We use these same criteria to judge if they deserve to die at the hands of law enforcement, or men like George Zimmerman. Because the question that white people are asking is not Why can’t we all be human?, but Why can’t you be like us?

HYPERAROUSAL After a traumatic experience, the human system of self-preservation seems to go onto permanent alert, as if the danger might return at any moment. Physiological arousal continues unabated. In this state of hyerarousal, which is the first cardinal symptom of post-traumatic stress disorder, the traumatized person startles easily, reacts irritably to small provocations, and sleeps poorly. Kardiner propsed that "the nucleus of the [traumatic] neurosis is physioneurosis."8 He believed that many of the symptoms observed in combat veterans of the First World War-startle reactions, hyperalertness, vigilance for the return of danger, nightmares, and psychosomatic complaints-could be understood as resulting from chronic arousal of the autonomic nervous system. He also interpreted the irritability and explosively aggressive behavior of traumatized men as disorganized fragments of a shattered "fight or flight" response to overwhelming danger.

The result of all this muscular effort, on both the larger scale and the smaller, is that your body burns calories and consumes oxygen at a rate that is unmatched in almost any other human endeavor. Physiologists, in fact, have calculated that rowing a two-thousand-meter race—the Olympic standard—takes the same physiological toll as playing two basketball games back-to-back. And it exacts that toll in about six minutes.

Attachment theory teaches us that true autonomy relies on feeling securely connected to other human beings. Current developments in the field of attachment science have recognized that bonded pairs, such as couples, or parents and children, build bonds that physiologically shape their nervous systems. Contrary to many Western conceptions of the self as disconnected and atomized, operating in isolation using nothing but grit and determination, it turns out that close-knit connections to others are in large part how we grow into our own, fully expressed, autonomous selves.

If you turn to a branch of those sciences that try to give a solution to the questions of life--to physiology, psychology, biology, sociology--there you will find an astounding poverty of thought, a very great lack of clarity, completely unjustified claims to answer questions that lie outside their subject and never-ending contradictions between one thinker and others, and even within himself. If you turn to a branch of the sciences that is not concerned with solving the questions of life but answers its own scientific, specialized questions, then you are captivated by the power of human intellect but you know in advance that there are no answers to the questions of life. These sciences directly ignore the questions of life. They say, "We have no answers to 'What are you?' and 'Why do you live?' and are not concerned with this; but if you need to know the laws of light, of chemical compounds, the laws of the development of organisms, if you need to know the laws of bodies and their forms and the relation of numbers and quantities, if you need to know the laws of your own mind, to all that we have clear, precise, and unquestionable answers.

Every day, hundreds of observations and experiments pour into the hopper of the scientific literature. Many of them don't have much to do with evolution - they're observations about the details of physiology, biochemistry, development, and so on - but many of them do. And every fact that has something to do with evolution confirms its truth. Every fossil that we find, every DNA molecule that we sequence, every organ system that we dissect, supports the idea that species evolved from common ancestors. Despite innumerable possible observations that could prove evolution untrue, we don't have a single one. We don't find mammals in Precambrian rocks, humans in the same layers as dinosaurs, or any other fossils out of evolutionary order. DNA sequencing supports the evolutionary relationships of species originally deduced from the fossil record. And, as natural selection predicts, we find no species with adaptations that only benefit a different species. We do find dead genes and vestigial organs, incomprehensible under the idea of special creation. Despite a million chances to be wrong, evolution always comes up right. That is as close as we can get to a scientific truth.

I had come to see language as an almost supernatural force, existing between people, bringing our brains, shielded in centimeter-thick skulls, into communion. A word meant something only between people, and life’s meaning, its virtue, had something to do with the depth of the relationships we form. It was the relational aspect of humans — i.e., “human relationality” — that undergirded meaning. Yet somehow, this process existed in brains and bodies, subject to their own physiologic imperatives, prone to breaking and failing. There must be a way, I thought, that the language of life as experienced — of passion, of hunger, of love — bore some relationship, however convoluted, to the language of neurons, digestive tracts, and heartbeats.

An amplifier host is a creature in which a virus or other pathogen replicates—and from which it spews—with extraordinary abundance. Some aspect of the host’s physiology, or its immune system, or its particular history of interaction with the bug, or who knows what, accounts for this especially hospitable role.

The capital ... shall form a fund, the interest of which shall be distributed annually as prizes to those persons who shall have rendered humanity the best services during the past year. ... One-fifth to the person having made the most important discovery or invention in the science of physics, one-fifth to the person who has made the most eminent discovery or improvement in chemistry, one-fifth to the one having made the most important discovery with regard to physiology or medicine, one-fifth to the person who has produced the most distinguished idealistic work of literature, and one-fifth to the person who has worked the most or best for advancing the fraternization of all nations and for abolishing or diminishing the standing armies as well as for the forming or propagation of committees of peace.

Liberalism rests on an abstract and ahistorical conception of the individual self and its realisation. What is needed is an examination of the historical and physiological evolution of human agency (which is what [Nietzsche] attempts in a Genealogy of Morality) in order to demonstrate the existence of different human types and different moralities.

In my mind android is a metaphor for people who are physiologically human but behaving in a nonhuman way.

Yet, at the quantum level, NO part of the body lives apart from the rest. There are no wires holding together the molecules of your arteries, just as there are no visible connections binding together the stars in a galaxy. Yet arteries and galaxies are both securely held together, in a seamless, perfect design. The invisible bonds that you cannot examine under a microscope are quantum in nature; without this "hidden physiology," your visible physiology could not exist. It would never have been more than a random collection of molecules.

What battles have in common is the human: the behavior of men struggling to reconcile their instinct of self-preservation, their sense of honor and the achievement of some aim over which other men are ready to kill them. The study of battle is therefore always a study of fear and usually of courage, usually also of faith and sometimes vision. —Sir Herbert Butterfield Man On His Past

The detox phenomenon is interesting because it represents one of the most grandiose innovations of marketers, lifestyle gurus, and alternative therapists: the invention of a whole new physiological process. In terms of basic human biochemistry, detox is a meaningless concept. It doesn’t cleave nature at the joints. There is nothing on the “detox system” in a medical textbook. That burgers and beer can have negative effects on your body is certainly true, for a number of reasons; but the notion that they leave a specific residue, which can be extruded by a specific process, a physiological system called detox, is a marketing invention.

We face no such difficulty if we see that what is being transmitted genetically is not ADD or its equally ill-mannered and discombobulating relatives, but sensitivity. The existence of sensitive people is an advantage for humankind because it is this group that best expresses humanity’s creative urges and needs. Through their instinctual responses the world is best interpreted. Under normal circumstances, they are artists or artisans, seekers, inventors, shamans, poets, prophets. There would be valid and powerful evolutionary reasons for the survival of genetic material coding for sensitivity. It is not diseases that are being inherited but a trait of intrinsic survival value to human beings. Sensitivity is transmuted into suffering and disorders only when the world is unable to heed the exquisitely tuned physiological and psychic responses of the sensitive individual.

Nature’s ultimate goal is to foster the growth of the individual from absolute dependence to independence — or, more exactly, to the interdependence of mature adults living in community. Development is a process of moving from complete external regulation to self-regulation, as far as our genetic programming allows. Well-self-regulated people are the most capable of interacting fruitfully with others in a community and of nurturing children who will also grow into self-regulated adults. Anything that interferes with that natural agenda threatens the organism’s chances for long-term survival. Almost from the beginning of life we see a tension between the complementary needs for security and for autonomy. Development requires a gradual and ageappropriate shift from security needs toward the drive for autonomy, from attachment to individuation. Neither is ever completely lost, and neither is meant to predominate at the expense of the other. With an increased capacity for self-regulation in adulthood comes also a heightened need for autonomy — for the freedom to make genuine choices. Whatever undermines autonomy will be experienced as a source of stress. Stress is magnified whenever the power to respond effectively to the social or physical environment is lacking or when the tested animal or human being feels helpless, without meaningful choices — in other words, when autonomy is undermined. Autonomy, however, needs to be exercised in a way that does not disrupt the social relationships on which survival also depends, whether with emotional intimates or with important others—employers, fellow workers, social authority figures. The less the emotional capacity for self-regulation develops during infancy and childhood, the more the adult depends on relationships to maintain homeostasis. The greater the dependence, the greater the threat when those relationships are lost or become insecure. Thus, the vulnerability to subjective and physiological stress will be proportionate to the degree of emotional dependence. To minimize the stress from threatened relationships, a person may give up some part of his autonomy. However, this is not a formula for health, since the loss of autonomy is itself a cause of stress. The surrender of autonomy raises the stress level, even if on the surface it appears to be necessary for the sake of “security” in a relationship, and even if we subjectively feel relief when we gain “security” in this manner. If I chronically repress my emotional needs in order to make myself “acceptable” to other people, I increase my risks of having to pay the price in the form of illness. The other way of protecting oneself from the stress of threatened relationships is emotional shutdown. To feel safe, the vulnerable person withdraws from others and closes against intimacy. This coping style may avoid anxiety and block the subjective experience of stress but not the physiology of it. Emotional intimacy is a psychological and biological necessity. Those who build walls against intimacy are not self-regulated, just emotionally frozen. Their stress from having unmet needs will be high.

Environmental influences also affect dopamine. From animal studies, we know that social stimulation is necessary for the growth of the nerve endings that release dopamine and for the growth of receptors that dopamine needs to bind to in order to do its work. In four-month-old monkeys, major alterations of dopamine and other neurotransmitter systems were found after only six days of separation from their mothers. “In these experiments,” writes Steven Dubovsky, Professor of Psychiatry and Medicine at the University of Colorado, “loss of an important attachment appears to lead to less of an important neurotransmitter in the brain. Once these circuits stop functioning normally, it becomes more and more difficult to activate the mind.” A neuroscientific study published in 1998 showed that adult rats whose mothers had given them more licking, grooming and other physical-emotional contact during infancy had more efficient brain circuitry for reducing anxiety, as well as more receptors on nerve cells for the brain’s own natural tranquilizing chemicals. In other words, early interactions with the mother shaped the adult rat’s neurophysiological capacity to respond to stress. In another study, newborn animals reared in isolation had reduced dopamine activity in their prefrontal cortex — but not in other areas of the brain. That is, emotional stress particularly affects the chemistry of the prefrontal cortex, the center for selective attention, motivation and self-regulation. Given the relative complexity of human emotional interactions, the influence of the infant-parent relationship on human neurochemistry is bound to be even stronger. In the human infant, the growth of dopamine-rich nerve terminals and the development of dopamine receptors is stimulated by chemicals released in the brain during the experience of joy, the ecstatic joy that comes from the perfectly attuned mother-child mutual gaze interaction. Happy interactions between mother and infant generate motivation and arousal by activating cells in the midbrain that release endorphins, thereby inducing in the infant a joyful, exhilarated state. They also trigger the release of dopamine. Both endorphins and dopamine promote the development of new connections in the prefrontal cortex. Dopamine released from the midbrain also triggers the growth of nerve cells and blood vessels in the right prefrontal cortex and promotes the growth of dopamine receptors. A relative scarcity of such receptors and blood supply is thought to be one of the major physiological dimensions of ADD. The letters ADD may equally well stand for Attunement Deficit Disorder.

If you want to know why the human primate behaves the way it does, I can easily explain: 1. human life span 2. human physiology at each stage of life="hormones" 3. our current state of evolution (still primitive in many ways). Humans are the only species on earth aware of their own deaths. They aren't here for long so they are very concerned with the quality of their lives more so than the quality of the lives that will come after them. It is our life spans that trap us, make us truly incapable of long-term decisions which would require sacrifice we as a species are not willing to make. Hormones: at each life stage, we are influenced heavily by hormones-raging levels in the young male or not, descending in the middle aged man or woman. Hormones also influence our behavior. Lastly, we are not out of the oven yet as far as evolution goes, still prone to settle our differences through primitive means--greed and violence. Here is a thought question for you-how would things differ if the average human could expect to live 200 years instead of 70+-?

Of course present knowledge of psychology is nearer to zero than to complete perfection, and its applications to teaching must therefore be often incomplete, indefinite, and insecure. The application of psychology to teaching is more like that of botany and chemistry to farming than like that of physiology and pathology to medicine. Anyone of good sense can farm fairly well without science, and anyone of good sense can teach fairly well without knowing and applying psychology. Still, as the farmer with the knowledge of the applications of botany and chemistry to farming is, other things being equal, more successful than the farmer without it, so the teacher will, other things being equal, be the more successful who can apply psychology, the science of human nature, to the problems of the school. (pp. 9-10)

Do people really drown and come to life again? Well, not really, but it can seem so. The mammalian dive reflex is triggered when a person is suddenly submerged, face and body, into very cold water. The body’s metabolism slows as the reflex redirects circulation away from the limbs and routes blood between the heart, brain, and lungs only. The heart can beat more slowly and oxygen is conserved for essential bodily processes, so as to maintain life for as long as possible. Once recovered from the water, the near-drowned person will appear dead. This physiological phenomenon was first written up in the medical journals in the middle of the twentieth century. The dive reflex is thought to occur in all mammals, both terrestrial and aquatic. It has been observed in adult humans but is believed to be most dramatic in small children.

Physiological stress, then, is the link between personality traits and disease. Certain traits — otherwise known as coping styles — magnify the risk for illness by increasing the likelihood of chronic stress. Common to them all is a diminished capacity for emotional communication. Emotional experiences are translated into potentially damaging biological events when human beings are prevented from learning how to express their feelings effectively. That learning occurs — or fails to occur — during childhood. The way people grow up shapes their relationship with their own bodies and psyches. The emotional contexts of childhood interact with inborn temperament to give rise to personality traits. Much of what we call personality is not a fixed set of traits, only coping mechanisms a person acquired in childhood. There is an important distinction between an inherent characteristic, rooted in an individual without regard to his environment, and a response to the environment, a pattern of behaviours developed to ensure survival. What we see as indelible traits may be no more than habitual defensive techniques, unconsciously adopted. People often identify with these habituated patterns, believing them to be an indispensable part of the self. They may even harbour self-loathing for certain traits — for example, when a person describes herself as “a control freak.” In reality, there is no innate human inclination to be controlling. What there is in a “controlling” personality is deep anxiety. The infant and child who perceives that his needs are unmet may develop an obsessive coping style, anxious about each detail. When such a person fears that he is unable to control events, he experiences great stress. Unconsciously he believes that only by controlling every aspect of his life and environment will he be able to ensure the satisfaction of his needs. As he grows older, others will resent him and he will come to dislike himself for what was originally a desperate response to emotional deprivation. The drive to control is not an innate trait but a coping style. Emotional repression is also a coping style rather than a personality trait set in stone. Not one of the many adults interviewed for this book could answer in the affirmative when asked the following: When, as a child, you felt sad, upset or angry, was there anyone you could talk to — even when he or she was the one who had triggered your negative emotions? In a quarter century of clinical practice, including a decade of palliative work, I have never heard anyone with cancer or with any chronic illness or condition say yes to that question. Many children are conditioned in this manner not because of any intended harm or abuse, but because the parents themselves are too threatened by the anxiety, anger or sadness they sense in their child — or are simply too busy or too harassed themselves to pay attention. “My mother or father needed me to be happy” is the simple formula that trained many a child — later a stressed and depressed or physically ill adult — into lifelong patterns of repression.

I don't myself think much of science as a phase of human development. It has given us a lot of ingenious toys; they take our attention away from the real problems, of course, and since the problems are insoluble, I suppose we ought to be grateful for distraction. But the fact is, the human mind, the individual mind, has always been made more interesting by dwelling on the old riddles, even if it makes nothing of them. Science hasn't given us any new amazements, except of the superficial kind we get from witnessing dexterity and sleight-of-hand. It hasn't given us any richer pleasures, as the Renaissance did, nor any new sins-not one! Indeed, it takes our old ones away. It's the laboratory, not the Lamb of God, that taketh away the sins of the world. You'll agree there is not much thrill about a physiological sin. We were better off when even the prosaic matter of taking nourishment could have the magnificence of a sin. I don't think you help people by making their conduct of no importance-you impoverish them. As long as every man and woman who crowded into the cathedrals on Easter Sunday was a principal in a gorgeous drama with God, glittering angels on one side and the shadows of evil coming and going on the other, life was a rich thing. The king and the beggar had the same chance at miracles and great temptations and revelations. And that's what makes men happy, believing in the mystery and importance of their own little individual lives. It makes us happy to surround our creature needs and bodily instincts with as much pomp and circumstance as possible. Art and religion (they are the same thing, in the end, of course) have given man the only happiness he has ever had.

The abyss that divides the two modalities of experience — sacred and profane — will be apparent when we come to describe sacred space and the ritual building of the human habitation, or the varieties of the religious experience of time, or the relations of religious man to nature and the world of tools, or the consecration of human life itself, the sacrality with which man’s vital functions (food, sex, work and so on) can be charged. Simply calling to mind what the city or the house, nature, tools, or work have become for modern and nonreligious man will show with the utmost vividness all that distinguishes such a man from a man belonging to any archaic society, or even form a peasant of Christian Europe. For modern consciousness, a physiological act — eating, sex, and so on — is in sum only an organic phenomenon, however much it may still be encumbered by tabus (imposing, for example, particular rules for "eating properly" or forbidding some sexual behavior disapproved by social morality). But for the primitive, such an act is never simply physiological; it is , or can become, a sacrament, that is, a communion with the sacred.

A word meant something only between people, and life’s meaning, its virtue, had something to do with the depth of the relationships we form. It was the relational aspect of humans—i.e., “human relationality”—that undergirded meaning. Yet somehow, this process existed in brains and bodies, subject to their own physiologic imperatives, prone to breaking and failing. There must be a way, I thought, that the language of life as experienced—of passion, of hunger, of love—bore some relationship, however convoluted, to the language of neurons, digestive tracts, and heartbeats.

Hormones are central to understanding obesity. Everything about human metabolism, including the body set weight, is hormonally regulated. A critical physiological variable such as body fatness is not left up to the vagaries of daily caloric intake and exercise. Instead, hormones precisely and tightly regulate body fat. We don't consciously control our body weight any more than we control our heart rates, our basal metabolic rates, our body temperatures or our breathing. These are all automatically regulated, and so is our weight. Hormones tell us when we are hungry (ghrelin). Hormones tell us we are full (peptide YY, cholecystokinin). Hormones increase energy expenditure (adrenalin). Hormones shut down energy expenditure (thyroid hormone). Obesity is a hormonal dysregulation of fat accumulation. Calories are nothing more than a proximate cause of obesity.

[Kinsey's studies included] stutterers, amputees, paraplegics, even those with cerebral palsy were observed. Kinsey wanted to document the full spectrum of human sexuality, but it was more than that. He believed these people might have things to teach us about the physiology of sex. And he was right. These groups alerted Kinsey--and the scientific community as a whole--to the complicated and crucial role of the central nervous system in sex and reproduction. Kinsey had noted that a stutterer in the throes of sexual abandon may temporarily lose his stutter. Similarly, the phantom limb pain some amputees feel temporarily disappears. Even the muscle spasticity of cerebral palsy may be briefly quieted. The body's limiting factors seem to get shut off. The organism is driven toward nature's singular goal--conception, the passing on of one's genes--and anything that stands in the way is pushed into the background.

As a special branch of general philosophy, pathogenesis had never been explored. In my opinion it had never been approached in a strictly scientific fashion--that is to say, objectively, amorally, intellectually. All those who have written on the subject are filled with prejudice. Before searching out and examining the mechanism of causes of disease, they treat of 'disease as such', condemn it as an exceptional and harmful condition, and start out by detailing the thousand and one ways of combating it, disturbing it, destroying it; they define health, for this purpose, as a 'normal' condition that is absolute and immutable. Diseases ARE. We do not make or unmake them at will. We are not their masters. They make us, they form us. They may even have created us. They belong to this state of activity which we call life. They may be its main activity. They are one of the many manifestations of universal matter. They may be the principal manifestation of that matter which we will never be able to study except through the phenomena of relationships and analogies. Diseases are a transitory, intermediary, future state of health. It may be that they are health itself. Coming to a diagnosis is, in a way, casting a physiological horoscope. What convention calls health is, after all, no more than this or that passing aspect of a morbid condition, frozen into an abstraction, a special case already experienced, recognized, defined, finite, extracted and generalized for everybody's use. Just as a word only finds its way into the Dictionary Of The French Academy when it is well worn stripped of the freshness of its popular origin or of the elegance of its poetic value, often more than fifty years after its creation (the last edition of the learned Dictionary is dated 1878), just as the definition given preserves a word, embalms it in its decrepitude, but in a pose which is noble, hypocritical and arbitrary--a pose it never assumed in the days of its vogue, while it was still topical, living and meaningful--so it is that health, recognized as a public Good, is only the sad mimic of some illness which has grown unfashionable, ridiculous and static, a solemnly doddering phenomenon which manages somehow to stand on its feet between the helping hands of its admirers, smiling at them with its false teeth. A commonplace, a physiological cliche, it is a dead thing. And it may be that health is death itself. Epidemics, and even more diseases of the will or collective neuroses, mark off the different epochs of human evolution, just as tellurian cataclysms mark the history of our planet.

A genetic fundamentalism permeates public awareness these days. It may be summed up as the belief that almost every illness and every human trait is dictated by heredity. Simplified media accounts, culled from semidigested research findings, have declared that inflexible laws of DNA rule the biological world. It was reported in 1996 that according to some psychologists, genes determine about 50 percent of a person’s inclination to experience happiness. Social ability and obesity are two more among the many human qualities now claimed to be genetic. True or not, narrow genetic explanations for ADD and every other condition of the mind do have their attractions. They are easy to grasp, socially conservative and psychologically soothing. They raise no uncomfortable questions about how a society and culture might erode the health of its members, or about how life in a family may have affected a person’s physiology or emotional makeup. As I have personally experienced, feelings of guilt are almost inevitable for the parents of a troubled child. They are all too frequently reinforced by the uninformed judgments of friends, neighbors, teachers or even total strangers on the bus or in the supermarket. Parental guilt, even if misplaced, is a wound for which the genetic hypothesis offers a balm

Current research in any field of Science has not yet reached the point where we could start exploring the existential question regarding God as a Supreme Entity driving causality in the universe. However, as modern Neuroscience progresses further and gets more advanced, we shall get to dive deeper into the physiological processes underneath the Qualia of God in human mind. What we have seen so far through our studies in Neurotheology, is that it is not God himself/herself/itself, rather it is people’s perception of God that influences the human life. The Qualia of God impact all aspects of human life by altering the body chemistry at a cellular level.

Over a decade prior, horrific cancer had deprived the world of an angel. My mother’s death had come quickly and unexpectedly. There was nothing that could be done to save her. She was admitted to the hospital, and a week later, she was gone, stolen from her beloved family and friends by the cells of her own body. Cells that had morphed from friend to mutant foe. Cells that, without remorse, mustered into a rogue army that cared nothing about extinguishing one of humanity’s true lights of kindness, compassion, and love. Malfunctions of biology and physiology had left only wonderful memories as well as the persistence of beauty in the lives she had touched.

If people throw up to us our works of fiction in which we write about people who are soft, weak, cowardly, and sometimes even downright bad, it's not be. cause these people are soft, weak, cowardly, or bad; because if we were to say, as Zola did, that they are that way because of heredity, the workings of environment, society, because of biological or psychological determinism, people would be reassured. They would say, "Well, that's what we're like, no one can do anything about it." But when the existentialist writes about a coward, he says that this coward is responsible for his cowardice. He's not like that because he has a cowardly heart or lung or brain; he's not like that on account of his physiological make-up; but he's like that because he has made himself a coward by his acts. There's no such thing as a cowardly constitution; there are nervous constitutions; there is poor blood, as the common people say, or strong constitutions. But the man whose blood is poor is not a coward on that account, for what makes cowardice is the act of renouncing or yielding. A constitution is not an act; the coward is defined on the basis of the acts he performs. People feel, in a vague sort of way, that this coward we're talking about is guilty of being a coward, and the thought frightens them. What people would like is that a coward or a hero be born that way.

Despite the intervening six decades of scientific inquiry since Selye’s groundbreaking work, the physiological impact of the emotions is still far from fully appreciated. The medical approach to health and illness continues to suppose that body and mind are separable from each other and from the milieu in which they exist. Compounding that mistake is a definition of stress that is narrow and simplistic. Medical thinking usually sees stress as highly disturbing but isolated events such as, for example, sudden unemployment, a marriage breakup or the death of a loved one. These major events are potent sources of stress for many, but there are chronic daily stresses in people’s lives that are more insidious and more harmful in their long-term biological consequences. Internally generated stresses take their toll without in any way seeming out of the ordinary. For those habituated to high levels of internal stress since early childhood, it is the absence of stress that creates unease, evoking boredom and a sense of meaninglessness. People may become addicted to their own stress hormones, adrenaline and cortisol, Hans Selye observed. To such persons stress feels desirable, while the absence of it feels like something to be avoided. When people describe themselves as being stressed, they usually mean the nervous agitation they experience under excessive demands — most commonly in the areas of work, family, relationships, finances or health. But sensations of nervous tension do not define stress — nor, strictly speaking, are they always perceived when people are stressed. Stress, as we will define it, is not a matter of subjective feeling. It is a measurable set of objective physiological events in the body, involving the brain, the hormonal apparatus, the immune system and many other organs. Both animals and people can experience stress with no awareness of its presence. “Stress is not simply nervous tension,” Selye pointed out. “Stress reactions do occur in lower animals, and even in plants, that have no nervous systems…. Indeed, stress can be produced under deep anaesthesia in patients who are unconscious, and even in cell cultures grown outside the body.” Similarly, stress effects can be highly active in persons who are fully awake, but who are in the grip of unconscious emotions or cut off from their body responses. The physiology of stress may be triggered without observable effects on behaviour and without subjective awareness, as has been shown in animal experiments and in human studies.

In 1944-1945, Dr Ancel Keys, a specialist in nutrition and the inventor of the K-ration, led a carefully controlled yearlong study of starvation at the University of Minnesota Laboratory of Physiological Hygiene. It was hoped that the results would help relief workers in rehabilitating war refugees and concentration camp victims. The study participants were thirty-two conscientious objectors eager to contribute humanely to the war effort. By the experiment's end, much of their enthusiasm had vanished. Over a six-month semi-starvation period, they were required to lose an average of twenty-five percent of their body weight." [...] p193 p193-194 "...the men exhibited physical symptoms...their movements slowed, they felt weak and cold, their skin was dry, their hair fell out, they had edema. And the psychological changes were dramatic. "[...] p194 "The men became apathetic and depressed, and frustrated with their inability to concentrate or perform tasks in their usual manner. Six of the thirty-two were eventually diagnosed with severe "character neurosis," two of them bordering on psychosis. Socially, they ceased to care much about others; they grew intensely selfish and self-absorbed. Personal grooming and hygiene deteriorated, and the men were moody and irritable with one another. The lively and cooperative group spirit that had developed in the three-month control phase of the experiment evaporated. Most participants lost interest in group activities or decisions, saying it was too much trouble to deal with the others; some men became scapegoats or targets of aggression for the rest of the group. Food - one's own food - became the only thing that mattered. When the men did talk to one another, it was almost always about eating, hunger, weight loss, foods they dreamt of eating. They grew more obsessed with the subject of food, collecting recipes, studying cookbooks, drawing up menus. As time went on, they stretched their meals out longer and longer, sometimes taking two hours to eat small dinners. Keys's research has often been cited often in recent years for this reason: The behavioral changes in the men mirror the actions of present-day dieters, especially of anorexics.

The resurrection of the body - what do we really mean by this? ...Did not the mystics and sages of all times teach us that the positive meaning of death is precisely that it liberates us from the prison of the body, as they say, from this perennial dependency on the material, physical, and bodily life - finally rendering our souls light, weightless, free, spiritual? We [must] consider more profoundly the meaning of the body... We must consider the role of the body in our, in my, life. On the one hand, of course it is entirely clear that all of our bodies are transitory and impermanent. Biologists have calculated that all the cells that compose our bodies are replaced every seven years. Thus, physiologically, every seven years we have a new body. Therefore, at the end of my life the body that is laid in the grave or consumed by fire is no longer the same body as all the preceding ones, and in the final analysis each of our bodies is nothing other than our individual [being] in the world, as the form of my dependence on the world, on the one hand, and of my life and of my activity on the other. In essence, my body is my relationship to the world, to others; it is my life as communion and as mutual relationship. Without exception, everything in the body, in the human organism, is created for this relationship, for this communion, for this coming out of oneself. It is not an accident, of course, that love, the highest form of communion, finds its incarnation in the body; the body is that which sees, hears, feels, and thereby leads me out of the isolation of my *I*. But then, perhaps, we can say in response: the body is not the darkness of the soul, but rather the body is its freedom, for the body is the soul as love, the soul as communion, the soul as life, the soul as movement. And this is why, when the soul loses the body, when it is separated from the body, it loses life.

On January 28, 1983, on the eve of the launch of the Human Genome Project, Carrie Buck died in a nursing home in Waynesboro, Pennsylvania. She was seventy-six years old. Her birth and death had bookended the near century of the gene. Her generation had borne witness to the scientific resurrection of genetics, its forceful entry into public discourse, its perversion into social engineering and eugenics, its postwar emergence as the central theme of the “new” biology, its impact on human physiology and pathology, its powerful explanatory power in our understanding of illness, and its inevitable intersection with questions of fate, identity, and choice. She had been one of the earliest victims of the misunderstandings of a powerful new science. And she had watched that science transform our understanding of medicine, culture, and society.

There are many buzzwords that gloss over these operations and their economic origins: “ambient computing,” “ubiquitous computing,” and the “internet of things” are but a few examples. For now I will refer to this whole complex more generally as the “apparatus.” Although the labels differ, they share a consistent vision: the everywhere, always-on instrumentation, datafication, connection, communication, and computation of all things, animate and inanimate, and all processes—natural, human, physiological, chemical, machine, administrative, vehicular, financial. Real-world activity is continuously rendered from phones, cars, streets, homes, shops, bodies, trees, buildings, airports, and cities back to the digital realm, where it finds new life as data ready for transformation into predictions, all of it filling the ever-expanding pages of the shadow text.4

We all know that we are material creatures, subject to the laws of physiology and physics, and not even the power of all our feelings combined can defeat those laws. All we can do is detest them. The age-old faith of lovers and poets in the power of love, stronger than death, that finis vitae sed non amoris, is a lie, useless and not even funny. So must one be resigned to being a clock that measures the passage of time, now out of order, now repaired, and whose mechanism generates despair and love as soon as its maker sets it going? Are we to grow used to the idea that every man relives ancient torments, which are all the more profound because they grow comic with repetition? That human existence should repeat itself, well and good, but that it should repeat itself like a hackneyed tune, or a record a drunkard keeps playing as he feeds coins into the jukebox...

Some cognitive scientists believe human response to music provides evidence that we are more than just flesh and blood—that we also have souls. Their thinking is as follows: All reactions to external stimuli can be traced back to an evolutionary rationale. You pull your hand away from fire to avoid physical harm. You get butterflies before an important speech because the adrenaline running through your veins has caused a physiological fight-or-flight response. But there is no evolutionary context within which people’s response to music makes sense—the tapping of a foot, the urge to sing along or get up and dance, there’s just no survival benefit to these activities. For this reason, some believe that our response to music is proof that there’s more to us than just biological and physiological mechanics—that the only way to be moved by the spirit, so to speak, is to have one in the first place. There

The cloning of human genes allowed scientists to manufacture proteins-and the synthesis of proteins opened the possibility of targeting the millions of biochemical reactions in the human body. Proteins made it possible for chemists to intervene on previously impenetrable aspects of our physiology. The use of recombinant DNA to produce proteins thus marked a transition not just between one gene and one medicine, but between genes and a novel universe of drugs.

The geneticist Antoine Danchin once used the parable of the Delphic boat to describe the process by which individual genes could produce the observed complexity of the natural world. In the proverbial story, the oracle at Delphi is asked to consider a boat on a river whose planks have begun to rot. As the wood decays, each plank is replaced, one by one—and after a decade, no plank is left from the original boat. Yet, the owner is convinced that it is the same boat. How can the boat be the same boat—the riddle runs—if every physical element of the original has been replaced? The answer is that the “boat” is not made of planks but of the relationship between planks. If you hammer a hundred strips of wood atop each other, you get a wall; if you nail them side to side, you get a deck; only a particular configuration of planks, held together in particular relationship, in a particular order, makes a boat. Genes operate in the same manner. Individual genes specify individual functions, but the relationship among genes allows physiology. The genome is inert without these relationships. That humans and worms have about the same number of genes—around twenty thousand—and yet the fact that only one of these two organisms is capable of painting the ceiling of the Sistine Chapel suggests that the number of genes is largely unimportant to the physiological complexity of the organism. “It is not what you have,” as a certain Brazilian samba instructor once told me, “it is what you do with it.

The Yogi practices exercises by which he attains control of his body, and is enabled to send to any organ or part an increased flow of vital force or “prana,” thereby strengthening and invigorating the part or organ. He knows all that his Western scientific brother knows about the physiological effect of correct breathing, but he also knows that the air contains more than oxygen and hydrogen and nitrogen, and that something more is accomplished than the mere oxygenating of the blood. He knows something about “prana,” of which his Western brother is ignorant, and he is fully aware of the nature and manner of handling that great principle of energy, and is fully informed as to its effect upon the human body and mind. He knows that by rhythmical breathing one may bring himself into harmonious vibration with nature, and aid in the unfoldment of his latent powers. He knows that by controlled breathing he may not only cure disease in himself and others, but also practically do away with fear and worry and the baser emotions.

The Good News: Taller, Longer-Lived, and Healthier Bodies The last 150 years have profoundly transformed how we eat, work, travel, fight disease, keep clean, and even sleep. It is as if the human species had a total makeover: our daily lives would be barely comprehensible to our ancestors from just a few generations ago, but we are essentially identical genetically, anatomically, and physiologically. The change has been so rapid that too little time has elapsed for more than a modicum of natural selection to have occurred.

Who cannot sympathize with the imprisoned Dmitri Karamazov as he tries to make sense of what he has just learned from a visiting academic? "Imagine: inside, in the nerves, in the head — that is, these nerves are there in the brain ... (damn them!) there are sort of little tails, the little tails of those nerves, and as soon as they begin quivering ... that is, you see, I look at something with my eyes and then they begin quivering, those little tails ... and when they quiver, then an image appears ... it doesn't appear at once, but an instant, a second, passes ... and then something like a moment appears; that is, not a moment — devil take the moment! — but an image; that is, an object, or an action, damn it! That's why I see and then think, because of those tails, not at all because I've got a soul, and that I am some sort of image and likeness. All that is nonsense! Rakitin explained it all to me yesterday, brother, and it simply bowled me over. It's magnificent, Alyosha, this science! A new man's arising — that I understand.... And yet I am sorry to lose God!" Dostoevsky's prescience is itself astonishing, because in 1880 only the rudiments of neural functioning were understood, and a reasonable person could have doubted that all experience arises from quivering nerve tails. But no longer. One can say that the information-processing activity of the brain causes the mind, or one can say that it is the mind, but in either case the evidence is overwhelming that every aspect of our mental lives depends entirely on physiological events in the tissues of the brain.

I took care to replace the Compendium in its correct pamphlet, and in doing so dislodged a slim pamphlet by Grastrom, one of the most eccentric authors in Solarist literature. I had read the pamphlet, which was dictated by the urge to understand what lies beyond the individual, man, and the human species. It was the abstract, acidulous work of an autodidact who had previously made a series of unusual contributions to various marginal and rarefied branches of quantum physics. In this fifteen-page booklet (his magnum opus!), Grastrom set out to demonstrate that the most abstract achievements of science, the most advanced theories and victories of mathematics represented nothing more than a stumbling, one or two-step progression from our rude, prehistoric, anthropomorphic understanding of the universe around us. He pointed out correspondences with the human body-the projections of our sense, the structure of our physical organization, and the physiological limitations of man-in the equations of the theory of relativity, the theorem of magnetic fields and the various unified field theories. Grastrom’s conclusion was that there neither was, nor could be any question of ‘contact’ between mankind and any nonhuman civilization. This broadside against humanity made no specific mention of the living ocean, but its constant presence and scornful, victorious silence could be felt between every line, at any rate such had been my own impression. It was Gibarian who drew it to my attention, and it must have been Giarian who had added it to the Station’s collection, on his own authority, since Grastrom’s pamphlet was regarded more as a curiosity than a true contribution to Solarist literature

You must control bugs,” I say. “Bugs no eat fruit,” it answers. In other words, how can you control an animal except with fruit? “Change sap for bugs. Like this.” I show a chemical. “Sap will control animals.” “Bugs no eat fruit.” “Bugs drink sap.” “Yes,” it says. “Bugs no eat fruit.” “Change sap for bugs because bugs drink sap, no eat fruit.” “Bugs no eat fruit.” I realize that we are related plants, both bamboos, in fact, and our shared physiology is the only reason I can have a conversation of any complexity. The hedge along the river is too small to have many sentient roots. The presence of other snow vines triggers an aggressive growth, but this hedge has lived alone and is content to lead a manicured little life parasitizing its aspens and putting down more guard roots than it needs, thus serving the humans without realizing it. It has no need for intelligence, none at all. “Change sap for bugs,” I repeat, hoping that repetition will of itself prove persuasive. “Big animals eat bugs.” “Bugs no eat fruit.” “Big animals eat bugs.” “Big animals eat bugs,” the snow vine repeats. I have made progress. “Yes,” I say. “Change sap for bugs.” “Big animals eat bugs.” “Yes. Change sap for bugs. Like this.” “Bugs eat sap,” it says. “Bugs are pests.” “Bugs are good. Big animals eat bugs like fruit.” The snow vine stammers some meaningless chemical compounds and finally says, “Bugs are like fruit.” This is very significant progress. “Bugs are like fruit,” I agree. “Bugs eat sap. Change sap. Sap will control two animals.” “Sap will control bugs. Big animals eat bugs.” “Yes. You must change sap for bugs and animals.” “I will change sap for bugs and animals.” At last! “Yes. Change sap like this.” I deliver some prototype chemicals.

The oft-observed relationship between stress, impaired immunity and illness has given rise to the concept of “diseases of adaptation,” a phrase of Hans Selye’s. The flight-or-fight response, it is argued, was indispensable in an era when early human beings had to confront a natural world of predators and other dangers. In civilized society, however, the flight-fight reaction is triggered in situations where it is neither necessary nor helpful, since we no longer face the same mortal threats to existence. The body’s physiological stress mechanisms are often triggered inappropriately, leading to disease. There

People's emotional states have a huge impact in their physiology. The interaction between emotions and physiology is 24/7, whether we are aware of it or not. But that means to say that we can't separate the mind from the body. And to understand any physiological process in the body you have to understand not just the physical aspects of it, but also the emotional and the environment in which it takes place. That's the first point. The second point is....so that people are bio-psychological creatures. Our biology cannot be separated from our psychology. But if you look at the stressed parents.. why are they stressed? Because they're unemployed. Because their communities are falling apart. Because their marriage might be in trouble. So we are not just bio-psychological creatures, we are bio-psycho-social creatures. In other words, our biology is significanty affected by the emotional environment which exists in a cultural, social environment. You simply cannot separate physiology, including the brain physiology and including the circuits of the brain from the psychological, emotional and social environment. You cannot do that. Not in real life. So that unity, that interconnectivity, interactivity of human beings is what missing from the conversation.

You’ve heard the expression “total war”; it’s pretty common throughout human history. Every generation or so, some gasbag likes to spout about how his people have declared “total war” against an enemy, meaning that every man, woman, and child within his nation was committing every second of their lives to victory. That is bullshit on two basic levels. First of all, no country or group is ever 100 percent committed to war; it’s just not physically possible. You can have a high percentage, so many people working so hard for so long, but all of the people, all of the time? What about the malingerers, or the conscientious objectors? What about the sick, the injured, the very old, the very young? What about when you’re sleeping, eating, taking a shower, or taking a dump? Is that a “dump for victory”? That’s the first reason total war is impossible for humans. The second is that all nations have their limits. There might be individuals within that group who are willing to sacrifice their lives; it might even be a relatively high number for the population, but that population as a whole will eventually reach its maximum emotional and physiological breaking point. The Japanese reached theirs with a couple of American atomic bombs. The Vietnamese might have reached theirs if we’d dropped a couple more, 2 but, thank all holy Christ, our will broke before it came to that. That is the nature of human warfare, two sides trying to push the other past its limit of endurance, and no matter how much we like to talk about total war, that limit is always there…unless you’re the living dead. For the first time in history, we faced an enemy that was actively waging total war. They had no limits of endurance. They would never negotiate, never surrender. They would fight until the very end because, unlike us, every single one of them, every second of every day, was devoted to consuming all life on Earth. That’s the kind of enemy that was waiting for us beyond the Rockies. That’s the kind of war we had to fight.

What we are talking about is a kind of super-reflex, a fundamental physiological ability of which we are barely aware. And like all specialized human traits, some people have much more mastery over this reflex than others. Part of what it means to have a powerful or persuasive personality, then, is that you can draw others into your own rhythms and dictate the terms of the interaction. In some studies, students who have a high degree of synchrony with their teachers are happier, more enthused, interested, and easygoing. What I felt with Gau was that I was being seduced, not in the sexual sense, of course, but in a global way, that our conversation was being conducted on his terms, not mine. I felt I was becoming synchronized with him. "Skilled musicians know this, and good speakers," says Joseph Cappella, who teaches at the Annenberg School of Communication at the University of Pennsylvania. "They know when the crowds are with them, literally in synchrony with them, in movements and nods and stillness in moments of attention." It is a strange thing to admit, because I didn't want to be drawn in. I was on guard against it. But the essence of Salesmen is that, on some level, they cannot be resisted. "Tom can build a level of trust and rapport in five to ten minutes that most people will take half an hour to do," Moine says to Gau.

Yoga has been superficially misunderstood by certain Western writers, but its critics have never been its practitioners. Among many thoughtful tributes to yoga may be mentioned one by Dr. C. G. Jung, the famous Swiss psychologist. “When a religious method recommends itself as ‘scientific,’ it can be certain of its public in the West. Yoga fulfills this expectation,” Dr. Jung writes (7). “Quite apart from the charm of the new, and the fascination of the half-understood, there is good cause for Yoga to have many adherents. It offers the possibility of controllable experience, and thus satisfies the scientific need of ‘facts,’ and besides this, by reason of its breadth and depth, its venerable age, its doctrine and method, which include every phase of life, it promises undreamed-of possibilities. “Every religious or philosophical practice means a psychological discipline, that is, a method of mental hygiene. The manifold, purely bodily procedures of Yoga (8) also mean a physiological hygiene which is superior to ordinary gymnastics and breathing exercises, inasmuch as it is not merely mechanistic and scientific, but also philosophical; in its training of the parts of the body, it unites them with the whole of the spirit, as is quite clear, for instance, in the Pranayama exercises where Prana is both the breath and the universal dynamics of the cosmos. “When the thing which the individual is doing is also a cosmic event, the effect experienced in the body (the innervation), unites with the emotion of the spirit (the universal idea), and out of this there develops a lively unity which no technique, however scientific, can produce. Yoga practice is unthinkable, and would also be ineffectual, without the concepts on which Yoga is based. It combines the bodily and the spiritual with each other in an extraordinarily complete way. “In the East, where these ideas and practices have developed, and where for several thousand years an unbroken tradition has created the necessary spiritual foundations, Yoga is, as I can readily believe, the perfect and appropriate method of fusing body and mind together so that they form a unity which is scarcely to be questioned. This unity creates a psychological disposition which makes possible intuitions that transcend consciousness.” The Western day is indeed nearing when the inner science of self- control will be found as necessary as the outer conquest of nature. This new Atomic Age will see men’s minds sobered and broadened by the now scientifically indisputable truth that matter is in reality a concentrate of energy. Finer forces of the human mind can and must liberate energies greater than those within stones and metals, lest the material atomic giant, newly unleashed, turn on the world in mindless destruction (9).

Overwork is repulsive to human nature—not work. Overwork for supplying the few with luxury—not work for the well-being of all. Work is a physiological necessity, a necessity of spending accumulated bodily energy, a necessity which is health and life itself. If so many branches of useful work are so reluctantly done now, it is merely because they mean overwork, or they are improperly organised. But we know—old Franklin knew it—that four hours of useful work every day would be more than sufficient for supplying everybody with the comfort of a moderately well-to-do middle-class house, if we all gave ourselves to productive work, and if we did not waste our productive powers as we do waste them now.

While all of us dread being blamed, we all would wish to be more responsible—that is, to have the ability to respond with awareness to the circumstances of our lives rather than just reacting. We want to be the authoritative person in our own lives: in charge, able to make the authentic decisions that affect us. There is no true responsibility without awareness. One of the weaknesses of the Western medical approach is that we have made the physician the only authority, with the patient too often a mere recipient of the treatment or cure. People are deprived of the opportunity to become truly responsible. None of us are to be blamed if we succumb to illness and death. Any one of us might succumb at any time, but the more we can learn about ourselves, the less prone we are to become passive victims. Mind and body links have to be seen not only for our understanding of illness but also for our understanding of health. Dr. Robert Maunder, on the psychiatric faculty of the University of Toronto, has written about the mindbody interface in disease. “Trying to identify and to answer the question of stress,” he said to me in an interview, “is more likely to lead to health than ignoring the question.” In healing, every bit of information, every piece of the truth, may be crucial. If a link exists between emotions and physiology, not to inform people of it will deprive them of a powerful tool. And here we confront the inadequacy of language. Even to speak about links between mind and body is to imply that two discrete entities are somehow connected to each other. Yet in life there is no such separation; there is no body that is not mind, no mind that is not body. The word mindbody has been suggested to convey the real state of things. Not even in the West is mind-body thinking completely new. In one of Plato’s dialogues, Socrates quotes a Thracian doctor’s criticism of his Greek colleagues: “This is the reason why the cure of so many diseases is unknown to the physicians of Hellas; they are ignorant of the whole. For this is the great error of our day in the treatment of the human body, that physicians separate the mind from the body.” You cannot split mind from body, said Socrates—nearly two and a half millennia before the advent of psychoneuroimmunoendocrinology!

The experience of stress has three components. The first is the event, physical or emotional, that the organism interprets as threatening. This is the stress stimulus, also called the stressor. The second element is the processing system that experiences and interprets the meaning of the stressor. In the case of human beings, this processing system is the nervous system, in particular the brain. The final constituent is the stress response, which consists of the various physiological and behavioural adjustments made as a reaction to a perceived threat. We see immediately that the definition of a stressor depends on the processing system that assigns meaning to it. The shock of an earthquake is a direct threat to many organisms, though not to a bacterium. The loss of a job is more acutely stressful to a salaried employee whose family lives month to month than to an executive who receives a golden handshake. Equally important is the personality and current psychological state of the individual on whom the stressor is acting. The executive whose financial security is assured when he is terminated may still experience severe stress if his self-esteem and sense of purpose were completely bound up with his position in the company, compared with a colleague who finds greater value in family, social interests or spiritual pursuits. The loss of employment will be perceived as a major threat by the one, while the other may see it as an opportunity. There is no uniform and universal relationship between a stressor and the stress response. Each stress event is singular and is experienced in the present, but it also has its resonance from the past. The intensity of the stress experience and its long-term consequences depend on many factors unique to each individual. What defines stress for each of us is a matter of personal disposition and, even more, of personal history. Selye discovered that the biology of stress predominantly affected three types of tissues or organs in the body: in the hormonal system, visible changes occurred in the adrenal glands; in the immune system, stress affected the spleen, the thymus and the lymph glands; and the intestinal lining of the digestive system. Rats autopsied after stress had enlarged adrenals, shrunken lymph organs and ulcerated intestines.

The educator must be as one inspired by a deep worship of life, and must, through this reverence, respect, while he observes with human interest, the development of the child life. Now, child life is not an abstraction; it is the life of individual children. There exists only one real biological manifestation: the living individual; and toward single individuals, one by one observed, education must direct itself. By education must be understood the active help given to the normal expansion of the life of the child. The child is a body which grows, and a soul which de- develops,–these two forms, physiological and psychic, have one eternal font, life itself. We must neither mar nor stifle the mysterious powers which lie within these two forms of growth, but we must await from them the manifestations which we know will succeed one another.

Man tends to regard the order he lives in as natural. The houses he passes on his way to work seem more like rocks rising out of the earth than like products of human hands. He considers the work he does in his office or factory as essential to the har­monious functioning of the world. The clothes he wears are exactly what they should be, and he laughs at the idea that he might equally well be wearing a Roman toga or medieval armor. He respects and envies a minister of state or a bank director, and regards the possession of a considerable amount of money the main guarantee of peace and security. He cannot believe that one day a rider may appear on a street he knows well, where cats sleep and chil­dren play, and start catching passers-by with his lasso. He is accustomed to satisfying those of his physio­logical needs which are considered private as dis­creetly as possible, without realizing that such a pattern of behavior is not common to all human so­cieties. In a word, he behaves a little like Charlie Chaplin in The Gold Rush, bustling about in a shack poised precariously on the edge of a cliff. His first stroll along a street littered with glass from bomb-shattered windows shakes his faith in the "naturalness" of his world. The wind scatters papers from hastily evacuated offices, papers labeled "Con­fidential" or "Top Secret" that evoke visions of safes, keys, conferences, couriers, and secretaries. Now the wind blows them through the street for anyone to read; yet no one does, for each man is more urgently concerned with finding a loaf of bread. Strangely enough, the world goes on even though the offices and secret files have lost all meaning. Farther down the street, he stops before a house split in half by a bomb, the privacy of people's homes-the family smells, the warmth of the beehive life, the furniture preserving the memory of loves and hatreds-cut open to public view. The house itself, no longer a rock, but a scaffolding of plaster, concrete, and brick; and on the third floor, a solitary white bath­ tub, rain-rinsed of all recollection of those who once bathed in it. Its formerly influential and respected owners, now destitute, walk the fields in search of stray potatoes. Thus overnight money loses its value and becomes a meaningless mass of printed paper. His walk takes him past a little boy poking a stick into a heap of smoking ruins and whistling a song about the great leader who will preserve the nation against all enemies. The song remains, but the leader of yesterday is already part of an extinct past.

Benjamin Libet, a scientist in the physiology department of the University of California, San Francisco, was a pioneering researcher into the nature of human consciousness. In one famous experiment he asked a study group to move their hands at a moment of their choosing while their brain activity was being monitored. Libet was seeking to identify what came first — the brain’s electrical activity to make the hand move or the person’s conscious intention to make their hand move. It had to be the second one, surely? But no. Brain activity to move the hand was triggered a full half a second before any conscious intention to move it…. John-Dylan Haynes, a neuroscientist at the Max Planck Institute for Human Cognitive and Brain Studies in Leipzig, Germany, led a later study that was able to predict an action ten seconds before people had a conscious intention to do it. What was all the stuff about free will? Frank Tong, a neuroscientist at Vanderbilt University in Nashville, Tennessee, said: “Ten seconds is a lifetime in terms of brain activity.” So where is it coming from if not ‘us,’ the conscious mind?

The Yoruba terms obinrin and okunrin do express a distinction. Reproduction is, obviously, the basis of human existence, and given its import, and the primacy of anafemale [anatomical female] body-type, it is not surprising that the Yoruba language describes the two types of anatomy. The terms okunrin and obinrin, however, merely indicate the physiological differences between the two anatomies as they have to do with procreation and intercourse. They refer, then, to the physically marked and physiologically apparent differences between the two anatomies. They do not refer to gender categories that connote social privileges and disadvantages. Also, they do not express sexual dimorphism because the distinction they indicate is specific to issues of reproduction. To appreciate this point, it would be necessary to go back to the fundamental difference between the conception of the Yoruba social world and that of Western societies.” “… I argued that the biological determinism in much of Western thought stems from the application of biological explanations in accounting for social hierarchies. This in turn has led to the construction of the social world with biological building blocks. Thus the social and the biological are thoroughly intertwined. This worldview is manifested in male-dominant gender discourses, discourses in which female biological differences are used to explain female sociopolitical disadvantages. The conception of biology as being ‘everywhere’ makes it possible to use it as an explanation in any realm, whether it is directly implicated or not. Whether the question is why women should not vote or why they breast-feed babies, the explanation is one and the same: they are biologically predisposed.” “The upshot of this cultural logic is that men and women are perceived as essentially different creatures. Each category is defined by its own essence. Diane Fuss describes the notion that things have a ‘true essence … as a belief in the real, the invariable and fixed properties which define the whatness of an entity.’ Consequently, whether women are in the labor room or in the boardroom, their essence is said to determine their behavior. In both arenas, then, women’s behavior is by definition different from that of men. Essentialism makes it impossible to confine biology to one realm. The social world, therefore, cannot truly be socially constructed.

It is clear, then, that the desire for certainty shapes our spaces of possibility, our perceptions, and our lives both personally and professionally. Usually, this need saves us. But it also sabotages us. This produces an ongoing tension between what we might think of as our conscious selves and our automatic selves. To overcome our inborn reflex that pushes us to seek certainty (sometimes at any cost), we must lead with our conscious selves and tell ourselves a new story, one that with insistent practice will change our future past and even our physiological responses. We must create internal and external ecologies that… celebrate doubt! This means the biggest obstacle to deviation and seeing differently isn’t actually our environment as such, or our” intelligence, or even—ironically—the challenge of reaching the mythical “aha” moment. Rather, it is the nature of human perception itself, and in particular the perceived need for knowing. Yet the deep paradox is that the mechanisms of perception are also the process by which we can unlock powerful new perceptions and ways to deviate. Which means that mechanism of generating a perception is the blocker… and the process of creating perception is the enabler of creativity

Men cooperate with one another. The totality of interhuman relations engendered by such cooperation is called society. Society is not an entity in itself. It is an aspect of human action. It does not exist or live outside of the conduct of people. It is an orientation of human action. Society neither thinks nor acts. Individuais in thinking and acting constitute a complex of relations and facts that are called social relations and facts. The issue has been confused by an arithmetical metaphor. Is society, people asked, merely a sum of individuals or is it more than this and thereby an entity endowed with independent reality? The question is nonsensical. Society is neither the sum of individuais nor more nor less. Arithmetical concepts cannot be applied to the matter. Another confusion arises from the no less empty question whether society is—in logic and in time—anterior to individuais or not. The evolution of society and that of civilization were not two distinct processes but one and the same process. The biological passing of a species of primates beyond the levei of a mere animal existence and their transformation into primitive men implied already the development of the first rudiments of social cooperation. Homo sapiens appeared on the stage of earthly events neither as a solitary foodseeker nor as a member of a gregarious flock, but as a being consciously cooperating with other beings of his own kind. Only in cooperation with his fellows could he develop language, the indispensable tool of thinking. We cannot even imagine a reasonable being living in perfect isolation and not cooperating at least with members of his family, clan, or tribe. Man as man is necessarily a social animal. Some sort of cooperation is an essential characteristic of his nature. But awareness of this fact does not justify dealing with social relations as if they were something else than relations or with society as if it were an independent entity outside or above the actions of individual men. Finally there are the misconstructions caused by the organismic metaphor. We may compare society to a biological organism. The tertium comparationis is the fact that division of labor and cooperation exist among the various parts of a biological body as among the various members of society. But the biological evolution that resulted in the emergence of the structurefunction systems of plant and animal bodies was a purely physiological process in which no trace of a conscious activity on the part of the cells can be discovered. On the other hand, human society is an intellectual and spiritual phenomenon. In cooperating with their fellows, individuais do not divest themselves of their individuality. They retain the power to act antisocially, and often make use of it. Its place in the structure of the body is invariably assigned to each cell. But individuais spontaneously choose the way in which they integrate themselves into social cooperation. Men have ideas and seek chosen ends, while the cells and organs of the body lack such autonomy.

Yes, there is a human nature and that human nature is build for love and contact. It is build for connection, it is build for mutual protection, it is build for mutual aid. And when we rear people in base of all society on the lines that transgress those needs, we're gonna get exactly what we have today. Which is a society which is increasingly conflicted, increasingly fractured, increasingly disconnected and where human pathology is, despite all the advances of medicine, chronic human pathology is on the rise. Western medicine does not recognize that the pathologies are manifestations of our life, that diseases don't have a life of their own, that diseases express the life of the individual. And if that individual's life is changed, so can the disease in many, many cases. And furthermore, that human beings have an innate healing capacity. There is a healing capacity in all living beings, plant or animal. And along with the wonders and contributions of Western medicine we could do so much more if we actually respected and evoked and encouraged that healing capacity that is within the individual, which is very much connected to the emergence of the true self. Now, for that, you need the truth. That means, we actually have to look at what is going on. And there is so much denial in this society. My own profession is a prime example. The average doctor does not hear the information I gave you about asthma. They couldn't explain it, even though the physiology is straightforward. For all the trauma in this society, the average physician does not hear the word "trauma" in all their years of training. Not that they don't get a lecture, not that they don't get a course, they don't even hear the word, except in the physical sense, physical trauma. Teachers are not taught that the human child's brain is still developing and that the conditions for healthy brain development is the presence of nurturing and responsive adults. And that schools are not knowledge factories, they are places where human development needs to be nurtured. That's a very different proposition for an educational system. And the courts don't get it. The courts think that if a human is behaving badly, it is a choice they're making, therefore they need to be punished. For some strange reason, certain minority groups have to be punished more than the average, like in my country 5% of the population is native, and they are 25% of the jail population now. And of course when we ask the question if the science is straightforward — as I believe it to be — and the conclusions are as clear as I believe them to be, why don't we just embrace it and follow it and do something about it? Well.. the reason for that is obvious, because if everything I just said happens to be true, which I firmly believe to be true, and if it is.. everything would have to change. How we teach parents would have to change, how we treat family would have to change, how we support young parents would have to change, how we pass laws, how we educate people, how we run the economy. We have to do something different. Getting to that something different has to begin with an inquiry and I hope I've said enough to encourage you to continue on that path of inquiry.

Much more than skeleton, it is flash, I mean the carrion flesh, which disturb and alarm us – and which alleviates us as well. The Buddhists monks gladly frequented charnel houses: where corner desire more surely and emancipate oneself from it? The horrible being a path of liberation in every period of fervor and inwardness, our remains have enjoyed great favor. In the Middle Ages, a man made a regimen of salvation, he believed energetically: the corpse was in fashion. Faith was vigorous than, invincible; it cherished the livid and the fetid, it knew the profits to be derived from corruption and gruesomeness. Today, an edulcorated religion adheres only to „nice” hallucinations, to Evolution and to Progress. It is not such a religion which might afford us the modern equivalent of the dense macabre. „Let a man who aspires to nirvana act so that nothing is dear to him”, we read in a Buddhist text. It is enough to consider these specters, to meditate on the fate of the flash which adhered to them, in order to understand the urgency of detachment. There is no ascesis in the double rumination on the flesh and on the skeleton, on the dreadful decrepitude of the one and the futile permanence of the other. It is a good exercise to sever ourselves now and then from our face, from our skin, to lay aside this deceptive sheathe, then to discard – if only for a moment – that layer of grease which keeps us from discerning what is fundamental in ourselves. Once exercise is over, we are freer and more alone, almost invulnerable. In other to vanquish attachments and the disadvantages which derive from them, we should have to contemplate the ultimate nudity of a human being, force our eyes to pierce his entrails and all the rest, wallow in the horror of his secretions, in his physiology of an imminent corpse. This vision would not be morbid but methodical, a controlled obsession, particularly salutary in ordeals. The skeleton incites us to serenity; the cadaver to renunciation. In the sermon of futility which both of them preach to us happiness is identified with the destruction of our bounds. To have scanted no detail of such a teaching and even so to come to terms with simulacra! Blessed was the age when solitaries could plumb their depths without seeming obsessed, deranged. Their imbalance was not assigned a negative coefficient, as is the case for us. They would sacrifice ten, twenty years, a whole life, for a foreboding, for a flash of the absolute. The word „depth” has a meaning only in connection with epochs when the monk was considered as the noblest human exemplar. No one will gain – say the fact that he is in the process of disappearing. For centuries, he has done no more than survive himself. To whom would he address himself, in a universe which calls him a „parasite”? In Tibet, the last country where monks still mattered, they have been ruled out. Yet is was a rare consolation to think that thousands of thousands of hermits could be meditating there, today, on the themes of the prajnaparamita. Even if it had only odious aspects, monasticism would still be worth more than any other ideal. Now more then ever, we should build monasteries … for those who believe in everything and for those who believe in nothing. Where to escape? There no longer exist a single place where we can professionally execrate this world.

Interactions with the world program our physiological and psychological development. Emotional contact is as important as physical contact. The two are quite analogous, as we recognize when we speak of the emotional experience of feeling touched. Our sensory organs and brains provide the interface through which relationships shape our evolution from infancy to adulthood. Social-emotional interactions decisively influence the development of the human brain. From the moment of birth, they regulate the tone, activity and development of the psychoneuroimmunoendocrine (PNI) super-system. Our characteristic modes of handling psychic and physical stress are set in our earliest years. Neuroscientists at Harvard University studied the cortisol levels of orphans who were raised in the dreadfully neglected child-care institutions established in Romania during the Ceausescu regime. In these facilities the caregiver/child ratio was one to twenty. Except for the rudiments of care, the children were seldom physically picked up or touched. They displayed the self-hugging motions and depressed demeanour typical of abandoned young, human or primate. On saliva tests, their cortisol levels were abnormal, indicating that their hypothalamic-pituitary-adrenal axes were already impaired. As we have seen, disruptions of the HPA axis have been noted in autoimmune disease, cancer and other conditions. It is intuitively easy to understand why abuse, trauma or extreme neglect in childhood would have negative consequences. But why do many people develop stress-related illness without having been abused or traumatized? These persons suffer not because something negative was inflicted on them but because something positive was withheld.

It may seem paradoxical to claim that stress, a physiological mechanism vital to life, is a cause of illness. To resolve this apparent contradiction, we must differentiate between acute stress and chronic stress. Acute stress is the immediate, short-term body response to threat. Chronic stress is activation of the stress mechanisms over long periods of time when a person is exposed to stressors that cannot be escaped either because she does not recognize them or because she has no control over them. Discharges of nervous system, hormonal output and immune changes constitute the flight-or-fight reactions that help us survive immediate danger. These biological responses are adaptive in the emergencies for which nature designed them. But the same stress responses, triggered chronically and without resolution, produce harm and even permanent damage. Chronically high cortisol levels destroy tissue. Chronically elevated adrenalin levels raise the blood pressure and damage the heart. There is extensive documentation of the inhibiting effect of chronic stress on the immune system. In one study, the activity of immune cells called natural killer (NK) cells were compared in two groups: spousal caregivers of people with Alzheimer’s disease, and age- and health-matched controls. NK cells are front-line troops in the fight against infections and against cancer, having the capacity to attack invading micro-organisms and to destroy cells with malignant mutations. The NK cell functioning of the caregivers was significantly suppressed, even in those whose spouses had died as long as three years previously. The caregivers who reported lower levels of social support also showed the greatest depression in immune activity — just as the loneliest medical students had the most impaired immune systems under the stress of examinations. Another study of caregivers assessed the efficacy of immunization against influenza. In this study 80 per cent among the non-stressed control group developed immunity against the virus, but only 20 per cent of the Alzheimer caregivers were able to do so. The stress of unremitting caregiving inhibited the immune system and left people susceptible to influenza. Research has also shown stress-related delays in tissue repair. The wounds of Alzheimer caregivers took an average of nine days longer to heal than those of controls. Higher levels of stress cause higher cortisol output via the HPA axis, and cortisol inhibits the activity of the inflammatory cells involved in wound healing. Dental students had a wound deliberately inflicted on their hard palates while they were facing immunology exams and again during vacation. In all of them the wound healed more quickly in the summer. Under stress, their white blood cells produced less of a substance essential to healing. The oft-observed relationship between stress, impaired immunity and illness has given rise to the concept of “diseases of adaptation,” a phrase of Hans Selye’s. The flight-or-fight response, it is argued, was indispensable in an era when early human beings had to confront a natural world of predators and other dangers. In civilized society, however, the flight-fight reaction is triggered in situations where it is neither necessary nor helpful, since we no longer face the same mortal threats to existence. The body’s physiological stress mechanisms are often triggered inappropriately, leading to disease. There is another way to look at it. The flight-or-fight alarm reaction exists today for the same purpose evolution originally assigned to it: to enable us to survive. What has happened is that we have lost touch with the gut feelings designed to be our warning system. The body mounts a stress response, but the mind is unaware of the threat. We keep ourselves in physiologically stressful situations, with only a dim awareness of distress or no awareness at all.

The traditional hospital practice of excluding parents ignored the importance of attachment relationships as regulators of the child’s emotions, behaviour and physiology. The child’s biological status would be vastly different under the circumstances of parental presence or absence. Her neurochemical output, the electrical activity in her brain’s emotional centres, her heart rate, blood pressure and the serum levels of the various hormones related to stress would all vary significantly. Life is possible only within certain well-defined limits, internal or external. We can no more survive, say, high sugar levels in our bloodstream than we can withstand high levels of radiation emanating from a nuclear explosion. The role of self-regulation, whether emotional or physical, may be likened to that of a thermostat ensuring that the temperature in a home remains constant despite the extremes of weather conditions outside. When the environment becomes too cold, the heating system is switched on. If the air becomes overheated, the air conditioner begins to work. In the animal kingdom, self-regulation is illustrated by the capacity of the warm-blooded creature to exist in a broad range of environments. It can survive more extreme variations of hot and cold without either chilling or overheating than can a coldblooded species. The latter is restricted to a much narrower range of habitats because it does not have the capacity to self-regulate the internal environment. Children and infant animals have virtually no capacity for biological self-regulation; their internal biological states—heart rates, hormone levels, nervous system activity — depend completely on their relationships with caregiving grown-ups. Emotions such as love, fear or anger serve the needs of protecting the self while maintaining essential relationships with parents and other caregivers. Psychological stress is whatever threatens the young creature’s perception of a safe relationship with the adults, because any disruption in the relationship will cause turbulence in the internal milieu. Emotional and social relationships remain important biological influences beyond childhood. “Independent self-regulation may not exist even in adulthood,” Dr. Myron Hofer, then of the Departments of Psychiatry and Neuroscience at Albert Einstein College of Medicine in New York, wrote in 1984. “Social interactions may continue to play an important role in the everyday regulation of internal biologic systems throughout life.” Our biological response to environmental challenge is profoundly influenced by the context and by the set of relationships that connect us with other human beings. As one prominent researcher has expressed it most aptly, “Adaptation does not occur wholly within the individual.” Human beings as a species did not evolve as solitary creatures but as social animals whose survival was contingent on powerful emotional connections with family and tribe. Social and emotional connections are an integral part of our neurological and chemical makeup. We all know this from the daily experience of dramatic physiological shifts in our bodies as we interact with others. “You’ve burnt the toast again,” evokes markedly different bodily responses from us, depending on whether it is shouted in anger or said with a smile. When one considers our evolutionary history and the scientific evidence at hand, it is absurd even to imagine that health and disease could ever be understood in isolation from our psychoemotional networks. “The basic premise is that, like other social animals, human physiologic homeostasis and ultimate health status are influenced not only by the physical environment but also by the social environment.” From such a biopsychosocial perspective, individual biology, psychological functioning and interpersonal and social relationships work together, each influencing the other.

All addictions — whether to drugs or to nondrug behaviours — share the same brain circuits and brain chemicals. On the biochemical level the purpose of all addictions is to create an altered physiological state in the brain. This can be achieved in many ways, drug taking being the most direct. So an addiction is never purely “psychological” all addictions have a biological dimension. And here a word about dimensions. As we delve into the scientific research, we need to avoid the trap of believing that addiction can be reduced to the actions of brain chemicals or nerve circuits or any other kind of neurobiological, psychological or sociological data. A multilevel exploration is necessary because it’s impossible to understand addiction fully from any one perspective, no matter how accurate. Addiction is a complex condition, a complex interaction between human beings and their environment. We need to view it simultaneously from many different angles — or, at least, while examining it from one angle, we need to keep the others in mind. Addiction has biological, chemical, neurological, psychological, medical, emotional, social, political, economic and spiritual underpinnings — and perhaps others I haven’t thought about. To get anywhere near a complete picture we must keep shaking the kaleidoscope to see what other patterns emerge. Because the addiction process is too multifaceted to be understood within any limited framework, my definition of addiction made no mention of “disease.” Viewing addiction as an illness, either acquired or inherited, narrows it down to a medical issue. It does have some of the features of illness, and these are most pronounced in hardcore drug addicts like the ones I work with in the Downtown Eastside. But not for a moment do I wish to promote the belief that the disease model by itself explains addiction or even that it’s the key to understanding what addiction is all about. Addiction is “all about” many things. Note, too, that neither the textbook definitions of drug addiction nor the broader view we’re taking here includes the concepts of physical dependence or tolerance as criteria for addiction. Tolerance is an instance of “give an inch, take a mile.” That is, the addict needs to use more and more of the same substance or engage in more and more of the same behaviour, to get the same rewarding effects. Although tolerance is a common effect of many addictions, a person does not need to have developed a tolerance to be addicted.