Hormone Health Quotes

Because now people use the phrase OCD to describe minor personality quirks. "Oooh, I like my pens in a line, I'm so OCD." NO YOU'RE FUCKING NOT. "Oh my God, I was so nervous about that presentation, I literally had a panic attack." NO YOU FUCKING DIDN'T. "I'm so hormonal today. I just feel totally bipolar." SHUT UP, YOU IGNORANT BUMFACE.

With all those negative emotions filling her mind and all those stress hormones coursing through her body, no vegetable, supplement, exercise program, or drug was going to be strong enough to counteract the harmful health effects of chronic stress responses on her body.

The mind and body are linked together in a meshwork of oxygen, nutrients, hormones, and neuron health. Physical exercise drives that meshwork, stimulating the brain and freeing one’s intellect.

Under normal conditions people react to a threat with a temporary increase in their stress hormones. As soon as the threat is over, the hormones dissipate and the body returns to normal. The stress hormones of traumatized people, in contrast, take much longer to return to baseline and spike quickly and disproportionately in response to mildly stressful stimuli. The insidious effects of constantly elevated stress hormones include memory and attention problems, irritability, and sleep disorders. They also contribute to many long-term health issues, depending on which body system is most vulnerable in a particular individual.

High quality sleep fortifies your immune system, balances your hormones, boosts your metabolism, increases physical energy, and improves the function of your brain.

Einstein once said, “If you can’t explain a concept to a six-year-old, you don’t fully understand it.

The doctor of the future will give no medication, but will interest his patients in the care of the human frame, diet, and in the cause and prevention of disease. —THOMAS EDISON

Clutter also adversely affects health. According to a study by scientists at UCLA, being surrounded by too many things increases cortisol levels, a primary stress hormone

If we added up all of the special ‘avoidance’ diets, no one could eat anything.  Many people are ruining their health by avoiding too many foods.” -Ray Peat

I think you´re beautiful. And I´m no stranger to fucked-up families." And then he was kissing her again. The addictive pull of his mouth almost had her crawling into his lap. Her hands bunched in his shirt, pulling him closer. [...] Layne always rolled her eyes in health class when they talked about hormones getting out of control. But right now, she could barely remember her name. She totally got how someone could forget something like a silly little condom. Suddenly Gabriel was laughing. "How someone could forget what?" She almost fell off the bench. "I said that out loud?" "Yeah." He leaned closer, his breath against her jaw. "Just what were you thinking about?

Weight gain, mood swings, fatigue, and low libido aren’t diseases that can be “cured” with a quick injection or a pharmaceutical. Most of these problems can’t be permanently solved by eating less or exercising more. They are hormonal problems. They mean our bodies are trying to tell us that something is wrong.

Many animals are also given growth hormones to further speed up the fattening process.18 These hormones are associated with a number of health risks in both animals and humans, including a possible correlation with cancer, which is why many countries no longer permit the use of hormones in industrial meat production.

Organic food production has existed for thousands of years (since the beginning of agriculture) and it will continue as long as humans live on the planet.

Stop exhuming the women's health initiative for which doctors prescribe hormones. The WHI for HRT standards is a dead and irrelevant paradigm to modern HRT that needs to be buried.

You can’t be in constant states of stress and improve your health at the same time.

Our tactics in Medicine 3.0 fall into five broad domains: exercise, nutrition, sleep, emotional health, and exogenous molecules, meaning drugs, hormones, or supplements.

The women's health initiative standards for HRT is nothing but an embarrassment to all physicians, and I'm not sure why they have not retracted all the statements that came out of that joke of a study.

One of the most important distinctions found within these pages is the fact that all foods are not created equal. Some foods are deficient in minerals and key nutrients, while other foods are packed with a powerhouse of valuable nutrients that can change your life, your health, and your body in a truly incredible way.

How many fluids should you take in daily?  That is an unanswerable question with all of the variables that affect our fluid needs at any given time.  If you meet anyone who can answer that question for you, run away quickly.

Present-day science, conventional medicine, and the mindset of 'better living through chemistry' have delivered their results, and they are less an excellent. Essentially, due to poor results, these methods no longer reign supreme.

You can do this (this thing, where your body will cease to produce hormones and your skin, hair, muscles and bones... basically every part of you will notice, go into withdrawals, and stage a coup). Be prepared for this mentally, and you'll own this "thing.

In the case of a human, it could be a dad hugging and listening. The buffer is hugely important, not just to attenuate the stress hormones but also to prevent the kind of epigenetic changes that lead to a dysregulated stress response and the major health issues that come with it.

Make sure your diet and lifestyle is something that you love and want to continue for life.  If you feel that way about it, you’ve found the healthiest diet for you.  Make the diet fit your life.  Don’t change your life around to fit your diet.  Don’t let the diet take over your life.  Let it play a supporting role in your life, helping you to feel better and have more energy for the things you would love to do and experience.

A study at Cornell University found that low-level noise both lowered job motivation and increased stress levels. It appears as well that an open-office type of environment can contribute to musculoskeletal problems such as a stiff back or tense neck and even heart disease due to increased levels of epinephrine, a stress hormone.

Licorice has highly negative effects on men’s androgen levels and hormonal functioning.

A wheat belly represents the accumulation of fat that results from years of consuming foods that trigger insulin, the hormone of fat storage.

I believe that love and forgiveness engages an incomprehensible healing force and sometimes true healing occurs, but always an emotional and spiritual healing happens.

What is it about our human nature that we feel the need to defend the choices we’ve made when it comes to our medical treatment?

Over time, stress hormones from multitasking can damage memory centers in the brain. Focus on one task at a time for better efficiency and memory.

Fertility is an expression of health, not a disease to be treated with a drug.

Many people have grown up with the notion that cow’s milk is a healthful beverage for children (or adults). I would encourage you to set this idea aside.

Weight loss is not a goal, it’s either something that happens or doesn’t happen as a result of living, eating, and moving in smarter and healthier ways.

A 100-calorie snack pack of cookies has a dramatically different effect on your body than half an avocado or a small handful of almonds with about the same number of calories.

Research has further shown that smiling may contribute to a decrease in stress induced hormones, lower heart rate and blood pressure, and may contribute to a healthier perspective on life.

Despite the newness of the science and tentativeness of the conclusions that can currently be drawn, changing women's hormones changes women. And this is a big deal. Although we don't yet know that the pill does the research suggests that it probably has a hand in women's mate preferences, our sensitivity to smells, our relationship satisfaction, the functioning of our stress response, the activities of multiple neurotransmitter systems, the activity of multiple hormones, our moods, our persistence in difficult tasks, our ability to learn and remember and our sex drive. And this is probably just the tip of the iceberg.

The hypothalamus, located directly below the thalamus, is only the size of a plump grape, but it regulates hormones that control blood pressure, body temperature, growth, and more. It is a no-fly zone during surgery.

The technology exists for a male contraceptive pill. We have the drugs to switch off testosterone and prevent sperm production. These drugs have never gone to market because developers know that men would never take something like that. Men would never agree to switch off their hormones. They would never put up with the side effects such as depression and low libido. And, honestly, why should they put up with it? Why should women?

The development of cognition, motivation, and self-regulation does not end with adolescence; indeed, personality traits do not reach their maximum stability until the third or fourth decade of life. This suggests that life history strategies are partially open to revision for a large portion of the life course -possibly depending on factors such as success in mating and reproduction, major environmental fluctuations, or unexpected changes in health, wealth or status.

Cutting carbs, fats, or calories (dieting) is like trying to hold your breath.  The longer you do it, the more your body resists it until you finally gasp for air – taking in more than ever to overcome the short-term deficit you induced.

In terms of nutritional content, a tablespoon of chia is like a smoothie made from salmon, spinach, and human growth hormone. As tiny as those seeds are, they’re superpacked with Omega-3s, protein, calcium, iron, zinc, fiber and antioxidants.

Fermented foods contain natural probiotics, or healthy bacteria, that can take your health to the next level. Nearly every culture has a version of a fermented food: yogurt, kefir, miso, and fermented vegetables, including sauerkraut, pickles, and kimchi.

Besides increasing energy and enhancing the immune system, laughter diminishes pain, improves focus, reignites hope, restores connections, enhances relationships, relieves tension, relaxes muscles, optimizes hormonal balance and reduces the effects of stress.

Your waist size is such an important predictor of health because the type of fat that is stored around your waistline—called “visceral fat” or “belly fat”—is related to the release of proteins and hormones that cause inflammation, which can in turn damage your arteries and affect how you metabolize sugars and fats. For this reason, visceral fat is strongly linked to type 2 diabetes, heart disease, stroke, Alzheimer’s, and other chronic diseases. Seeing your waist size come down is a great indicator of improving health.

Next is diet or nutrition—or as I prefer to call it, nutritional biochemistry. The third domain is sleep, which has gone underappreciated by Medicine 2.0 until relatively recently. The fourth domain encompasses a set of tools and techniques to manage and improve emotional health. Our fifth and final domain consists of the various drugs, supplements, and hormones that doctors learn about in medical school and beyond. I lump these into one bucket called exogenous molecules, meaning molecules we ingest that come from outside the body.

Your diet shouldn’t have a name or be something you can tweet about using the # sign.  If you, in your chronic dieting ways must name it, it should be your first name, followed by an apostrophe s, and the word “Diet.”  So for example, what I eat is referred to as “Matt’s Diet.”  If your name is Jean Claude Van Damme, then what you eat is called “Jean Claude’s Diet,” and probably consists mostly of metal chards and King Cobra filets.  If your name is Shooter McGavin, then you probably eat pieces of shit like Happy Gilmore for breakfast.

It is undignified to inject yourself with hormones designed to slow or enhance ovarian production. It is undignified to have your ovaries monitored by transvaginal ultrasound; to be sedated so that your eggs can be aspirated into a needle; to have your husband emerge sheepishly from a locked room with the “sample” that will be combined with your eggs under supervision of an embryologist. The grainy photo they hand you on transfer day, of your eight-celled embryo (which does not look remotely like a baby), is undignified, and so is all the waiting and despairing that follows.

Yet to understand modern economic history, you really need to understand just a single word. The word is growth. For better or worse, in sickness and in health, the modern economy has been growing like a hormone-soused teenager. It eats up everything it can find and puts on inches faster than you can count.

The defenders of feeling-based marriage venerate emotions for their authenticity only because they avoid looking closely at what actually floats through most people's emotional kaleidoscopes, all the contradictory, sentimental, and hormonal forces that pull us in a hundred often crazed and inconclusive directions. We could not be fulfilled if we weren't inauthentic some of the time—inauthentic, that is, in relation to such things as our passing desires to throttle our children, poison our spouse, or end our marriage over a dispute about changing a lightbulb. A degree of repression is necessary for both the mental health of our species and the adequate functioning of a decently ordered society. We are chaotic chemical propositions. We should feel grateful for, and protected by, the knowledge that our external circumstances are often out of line with what we feel; it is a sign that we are probably on the right course.

Black cohosh is highly estrogenic and is often used for normalizing female hormonal levels during menopause and to alleviate menopausal symptoms such as hot flashes. It has shown an antagonist activity toward the production and release of luteinizing hormone (LH), which is essential in testosterone production.

Sitting here in my lab, I can imagine you scratching your head again: Dr. Panda, what’s the big deal? Aren’t we talking about just a few ounces of fat gain after a late-night snack? Won’t my metabolic rhythm come back the next day? Actually, it’s worse than you think. It is hard enough for the body to monitor hormones, genes, and clocks for someone with a strict eating routine. But when eating occurs at random times throughout the day and night, the fat-making process stays on all the time. At the same time, glucose created from digested carbohydrates floods our blood and the liver becomes inefficient in its ability to absorb glucose. If this continues for a few days, blood glucose continues to rise and reaches the danger zone of prediabetes or diabetes. So, if you’ve wondered why diets haven’t worked for you before, timing might be the reason. Even if you were diligently exercising; counting calories; avoiding fats, carbs, and sweets; and piling on the protein, it’s quite likely that you weren’t respecting your circadian clocks. If you eat late at night or start breakfast at a wildly different time each morning, you are constantly throwing your body out of sync. Don’t worry, the fix is equally simple: Just set an eating routine and stick to it. Timing is everything.

These visceral (belly) fat cells behave differently than fat elsewhere in the body in two important ways.25 First, they are several times more sensitive to hormones and thus tend to be more metabolically active, which means they are capable of storing and releasing fat more rapidly than fat cells in other parts of the body. Second, when visceral cells release fatty acids (something fat cells do all the time), they dump the molecules almost straight into the liver, where the fat accumulates and eventually impairs the liver’s ability to regulate the release of glucose into the blood. An excess of belly fat (a paunch) is therefore a much greater risk factor for metabolic disease than a high BMI.

Given everything we’ve discovered about the relationship between hormones, menopause, and brain health, a larger question remains: Can the use of birth control affect the health of the brain? Oddly enough, even though more than 100 million women take the pill worldwide, there have been only a handful of studies dedicated to its effects on the brain.

It should come as absolutely no surprise that research has ignored women for so long because the establishment: the journal publishers, the reviewers and the funding agencies has rewarded it. Although the things are changing for the better in the US federal agencies will no longer fund clinical trials involving humans that do not include women... there is still a long way to go [..] Thoughtful, carefully done research on females still takes longer and costs more and is often times harder to interpret than research conducted only on males. So when people's careers depend on their publication rate rather than the need for answers to the questions they are asking, women and the issues they care about most - loose.

My main point is to show how so-called health values of therapy, hormonal treatment, and surgery have replaced ethical values of choice, freedom, and autonomy; how these same “health” values have diffused critical awareness about the social context in which the problem of transsexualism arises; how more and more moral problems have been reclassified as technical problems

Because now mental health disorders have gone “mainstream”. And for all the good it’s brought people like me who have been given therapy and stuff, there’s a lot of bad it’s brought too. Because now people use the phrase OCD to describe minor personality quirks. “Oooh, I like my pens in a line, I’m so OCD.” NO YOU’RE FUCKING NOT. “Oh my God, I was so nervous about that presentation, I literally had a panic attack.” NO YOU FUCKING DIDN’T. “I’m so hormonal today. I just feel totally bipolar.” SHUT UP, YOU IGNORANT BUMFACE. Told you I got angry. These words – words like OCD and bipolar – are not words to use lightly. And yet now they’re everywhere. There are TV programmes that actually pun on them. People smile and use them, proud of themselves for learning them, like they should get a sticker or something. Not realizing that if those words are said to you by a medical health professional, as a diagnosis of something you’ll probably have for ever, they’re words you don’t appreciate being misused every single day by someone who likes to keep their house quite clean. People actually die of bipolar, you know? They jump in front of trains and tip down bottles of paracetamol and leave letters behind to their devastated families because their bullying brains just won’t let them be for five minutes and they can’t bear to live with that any more. People also die of cancer. You don’t hear people going around saying: “Oh my God, my headache is so, like, tumoury today.” Yet it’s apparently okay to make light of the language of people’s internal hell

Avoid Menstruating If, you are using hormonal contraception, such as a low-dose birth control pill, you can avoid the whole change in pH caused by menstrual blood by avoiding menstruation. That’s right! Take your pill straight through the placebo days and skip having your period. And yes, this is safe. As discussed in chapter 9, skipping menstruation is a common treatment for endometriosis.

Hormonal responses to various fetal and childhood experiences have epigenetic effects on genes related to the growth factor BDNF, to the vasopressin and oxytocin system, and to estrogen sensitivity. These effects are pertinent to adult cognition, personality, emotionality, and psychiatric health. Childhood abuse, for example, causes epigenetic changes in hundreds of genes in the human hippocampus.

Despite the intervening six decades of scientific inquiry since Selye’s groundbreaking work, the physiological impact of the emotions is still far from fully appreciated. The medical approach to health and illness continues to suppose that body and mind are separable from each other and from the milieu in which they exist. Compounding that mistake is a definition of stress that is narrow and simplistic. Medical thinking usually sees stress as highly disturbing but isolated events such as, for example, sudden unemployment, a marriage breakup or the death of a loved one. These major events are potent sources of stress for many, but there are chronic daily stresses in people’s lives that are more insidious and more harmful in their long-term biological consequences. Internally generated stresses take their toll without in any way seeming out of the ordinary. For those habituated to high levels of internal stress since early childhood, it is the absence of stress that creates unease, evoking boredom and a sense of meaninglessness. People may become addicted to their own stress hormones, adrenaline and cortisol, Hans Selye observed. To such persons stress feels desirable, while the absence of it feels like something to be avoided. When people describe themselves as being stressed, they usually mean the nervous agitation they experience under excessive demands — most commonly in the areas of work, family, relationships, finances or health. But sensations of nervous tension do not define stress — nor, strictly speaking, are they always perceived when people are stressed. Stress, as we will define it, is not a matter of subjective feeling. It is a measurable set of objective physiological events in the body, involving the brain, the hormonal apparatus, the immune system and many other organs. Both animals and people can experience stress with no awareness of its presence. “Stress is not simply nervous tension,” Selye pointed out. “Stress reactions do occur in lower animals, and even in plants, that have no nervous systems…. Indeed, stress can be produced under deep anaesthesia in patients who are unconscious, and even in cell cultures grown outside the body.” Similarly, stress effects can be highly active in persons who are fully awake, but who are in the grip of unconscious emotions or cut off from their body responses. The physiology of stress may be triggered without observable effects on behaviour and without subjective awareness, as has been shown in animal experiments and in human studies.

IN THE FLO MANIFESTO I acknowledge my cycle has four distinct hormonal patterns. Each of these phases requires different nourishment and self-care. Supporting each phase is the key to optimizing my health. Syncing with each phase allows me to tap into creativity to optimize work, motherhood, and relationships on my own terms. Living according to my biological rhythmic timing restores my sovereignty and makes me more free.

What Happened to Male Birth Control? A 2016 trial of injectable male contraceptive was suspended after determining that the risks to men’s health outweighed the benefits. What brought researchers to that conclusion? Out of 320 men, 20 said they couldn’t tolerate the side effects, which included pain at the injection site, acne, and depression. Yes, based on 20 men saying they were uncomfortable with these symptoms, researchers discontinued the

Anyone can prove whatever they want. It's easy. I could "prove," via those mechanisms that carbs are the devil, fat is the devil, protein is the devil, grains destroy your digestive tract, grains are the ultimate food for digestive health, fruit is the devil, fruit is the salvation of mankind, dairy is the perfect food, dairy is atherogenic, dairy causes autoimmune disease, dairy cures autoimmune disease, fat makes you fat, fat makes you thin...

High blood triglycerides interfere with the function of the hormone leptin, causing you to want to overeat rather than rely on your stored body fat for energy. Possibly one-third of the population is fructose intolerant to some degree, evidenced by digestive symptoms such as flatulence, cramps, bloating, irritable bowel syndrome, and diarrhea. Excessive fructose consumption is also linked to fatigue, insulin resistance, diabetes, and high blood pressure.

For a long time being female was treated by science and medicine as being akin to having a serious psychological disorder. Women were routinely prescribed hysterectomies or anxiolytics like valium to treat the symptoms of hysteria which is a syndrome with symptoms that are suspiciously similar to the symptoms of being of human female who has to deal with stupid sexist bullshit. Although scions and medicine has come a long way since these sorts of practices were common place every woman i know has had an experience of being treated as less rational version of a man. Sometimes even by our own doctors simply by virtue of our gender. There belief that women are irrational and therefore underserving of the same rights as men is something that has lingered in the public consciousness in a huge way. And women are very aware of this. We have to listen to a lot of people say a lot of dumb shit about our hormones and about whether we deserve the right to control our own fertility. These types of claims particularly when combined with sciences and medicine mishandling of women for so long have made it very difficult for anyone, even female scientists, to have thoughtful conversations about things like women's hormones and fertility regulation. These topics unaddressed by science are often met with suspicion by anyone who has ever owned a pair of ovaries or is an ovarian sympatist.

The other major hormonal player in your cycle is progesterone. It helps to prepare the uterus for implantation with a healthy fertilized egg and supports pregnancy. If no implantation occurs, progesterone levels drop, and another cycle begins. Progesterone receptors are highly concentrated in the brain. Progesterone can support GABA, the brain’s relaxation neurotransmitter; acts to protect your nerve cells; and supports the myelin sheath that covers neurons. I like to think of progesterone as the “feel-good hormone.” It makes you feel calm and peaceful and encourages sleep. It’s like nature’s Valium, but better, because instead of making your brain fuzzy, it sharpens your thinking. It has also been shown to help with brain injuries by reducing inflammation and counteracting damage. It is so much more than a sex hormone. Progesterone increases during pregnancy, which is why many pregnant women often feel great. Some women with hormonal issues, in fact, feel so much better during pregnancy that they will

Several female hormones, which increase with the onset of puberty, were lowered by 20–30% (even 50% lower levels for progesterone!) simply by having girls eight to ten years of age consume a modestly low-fat, low animal-based food diet for seven years.47 These results are extraordinary because they were obtained with a modest dietary change and were produced during a critical time of a young girl’s life, when the first seeds of breast cancer were being sowed. These girls consumed a diet of no more than 28% fat and less than 150 mg cholesterol/day: a moderate plant-based diet.

Today, genetically modified ingredients are found in at least 75 percent of all non-organic U.S. processed foods, including in many products labeled as “natural” or “all natural.” But are they good for us? Our government says GMOs are no biggie, yet the European Union, Australia, and Japan have restricted or banned them. Based on animal research, the American Academy of Environmental Medicine (AAEM), an international organization of physicians, has stated that there are serious health problems linked to eating genetically modified foods, such as infertility, immune system problems, accelerated aging, insulin problems, cholesterol regulation, gut problems, and organ damage.

formulas as easy as possible, I’ve simplified my recommendation to just five core probiotic species that are widely available: Lactobacillus plantarum, Lactobacillus acidophilus, Lactobacillus brevis, Bifidobacterium lactis, and Bifidobacterium longum. Different strains provide different benefits, but these are the ones that will, as we’ve been discussing since the beginning of the book, best support brain health in these ways: • Fortifying the intestinal lining and reducing gut permeability • Reducing LPS, the inflammatory molecule that can be dangerous if it reaches the bloodstream • Increasing BDNF, the brain’s growth hormone • Sustaining an overall balance to crowd out any

A study in the Journal of Neuroscience tested pain sensitivity in women at different times during their menstrual cycle—first during their period when estradiol is at its lowest and then when their estradiol levels were at their highest. The women in the study were subjected to a controlled amount of pain and asked to rate the level of their discomfort. At low levels of estradiol, the women reported feeling much more pain than when the hormone was at its highest. The implication is that when your estrogen levels are low, such as during menopause or during the premenstrual or menstrual phase of your cycle, you are likely to feel pain more acutely, which is also likely true for emotional pain. Just one more reason a smart man is especially sensitive at this time!

Reproductive hormones aren’t the only hormones that affect how you look and feel and think. Among the most influential are the hormones produced by your thyroid gland. Too little thyroid, and you feel like a slug. Hypothyroidism makes you feel like you just want to lie on the couch all day with a bag of chips. Everything works slower, including your heart, your bowels, and your brain. When we perform SPECT scans of people with hypothyroidism, we see decreased brain activity. Many other studies confirm that overall low brain function in hypothyroidism leads to depression, cognitive impairment, anxiety, and feelings of being in a mental fog. The thyroid gland drives the production of many neurotransmitters that run the brain, such as serotonin, dopamine, adrenaline, and noradrenaline. A

Wealthy queers support initiatives that lock up and murder poor queers, trans* people, and sex workers. Women in positions of power continue to defend and sometimes initiate the vicious assault on abortion and reproductive rights, and then off-load reproductive labor onto the shoulders of care workers, who are predominantly women of color whose employment is often directly tied to their citizenship status. The politics of "leaning in" for a small layer of wealthy women has dovetailed with budget cuts and health care rollbacks that have left poor women at the mercy of misogynist, increasingly lethal anti-reproductive-rights legislation, and left poor, queer and trans* people without access to necessary medical resources like hormones or AIDS medication. Original pamphlet: Who is Oakland. April 2012. Quoted in: Dangerous Allies. Taking Sides.

Imagine yourself having a fight with your romantic partner. The tension of the situation makes your limbic system run at full throttle and you become flooded with stress hormones like cortisol and adrenalin. The high levels of these chemicals suddenly make you so damn angry, that you burst out in front of your partner saying, “I wish you die, so that I can have some peace in my life”. Given the stress of the situation through highly active limbic system, your PFC loses its freedom to take the right decision and you burst out with foul language in front of your partner, that may ruin your relationship. In simple terms due to your mental instability, you lost your free will to make the right decision. But when the conversation is over, and you relax for a while, your stress hormone levels come down to normal, and you regain your usual cheerful state of mind. Immediately, your PFC starts analyzing the explosive conversation you had with your partner. Healthy activity of the entire frontal lobes, especially the PFC suddenly overwhelms you with a feeling of guilt. Your brain makes you realize, that you have done something devilish. As a result, now you find yourself making the willful decision of apologizing to your partner and making up to him or her, no matter how much effort it takes, because your PFC comes up the solution that it is the healthiest thing to do for your personal life. From this you can see, that what you call free will is something that is not consistent. It changes based on your mental health. Mental instability or illness, truly cripples your free will. And the healthier your frontal lobes are, the better you can take good decisions. And the most effective way to keep your frontal lobes healthy is to practice some kind of meditation.

Whenever possible, avoid animal protein that has been raised with hormones or antibiotics. Europe won’t accept hormone-laden U.S. beef because of the health risks. Look for grass-fed, hormone-free, antibiotic-free organic beef and chicken, which is richer in omega-3 fatty acids and will therefore act to reduce inflammation and help your hormone receptors to function properly. Also, eat organic vegetables, fruits, nuts, seeds, beans, and grains. Pesticides are known to cause hormonal imbalances and some pesticides have been shown to act as “endocrine (hormone) disrupters,” interfering with the body’s natural hormone systems and causing an array of health problems. While the Environmental Protection Agency began looking at this issue in 1999, little change has yet occurred in the marketplace, and women are well served by educating themselves on this important issue. (I’ll discuss this more later in this chapter.)

We have witnessed hundreds of clients and patients damage their metabolic and hormonal health through low-carb diets. It is becoming increasingly apparent that there is an epidemic of metabolic and hormonal dysfunction emerging in the hordes of people who have been following low-carb diets. This is particularly impactful for women—and especially physically active women—who commonly suffer side effects from their low-carb diets, including: A stopped or irregular menstrual cycle (amenorrhea)418 419 420 421 422 Decreased fertility423 424 425 Hypoglycemic episodes and blood sugar swings426 Depression, anxiety, and irritability427 428 429 Poor libido430 431 432 Disrupted sleep/insomnia433 434 Dysfunctional relationship with food and fear about eating either fat or carbohydrate435 436 Cycles of restriction and binges437 438 Chronic fatigue 439 440 441 442 Poor thyroid function (and a slow metabolism)443 444 445 446 447 448

In human studies, black cohosh has been found to decrease hot flashes associated with menopause. Unlike conventional estrogen effects on individuals predisposed to breast cancer, black cohosh has been shown in laboratory studies to inhibit cancer cells. Most studies used doses of 20–80 mg twice daily, providing 4–8 mg triterpene glycosides for up to six months. Melatonin—This hormone is produced in the pineal gland that, among other functions, helps sleep. Melatonin levels decline with age and may lead to the sleep disturbances common during menopause. Melatonin has been shown in laboratory studies to inhibit the growth of breast cancer cells. Melatonin acts as an anti-inflammatory and antioxidant in the brain and other tissues like the intestine. Studies show that low melatonin levels increase breast cancer risk in women. So if you are having trouble sleeping consider 3–6 mg of melatonin before bed. It may boost your immune system and help you sleep.

The prefrontal cortex is a complex, fragile region of the brain. In its healthy state, it directs human impulses toward rational choices and away from destructive or self destructive behavior. It allows us to deal with the present moment while storing plans for the future. Yet as the newest part of the brain to develop in human evolution, the prefrontal cortex is also the region that takes the longest time to reach maturity, or maximum operating efficiency. It will not be fully functional until the person is past the age of twenty. This out of sync progress ranks among the most profound natural misfortunes of humanity. For while the prefrontal cortex is taking its time, other powerful components of the humaninprogress have raced across the finish line and function without the cortex's restraints. A young adult with a still developing prefrontal cortex will have reached .physical maturity, which of course means the capacity to reproduce and the strong hormonal drive to do so.

At the first trans health conference I ever attended, a parent asked about long-term health risks for people taking hormones. The doctor gave a full assessment of issues that trans men face; many of them mimic the risks that would be inherited from father to son if they'd been born male, now that testosterone is a factor. "What about trans women?" another parent asked. The doctor took a deep breath. "Those outcomes are murkier. Because trans women are so discriminated against, they're at far greater risk for issues like alcoholism, poverty, homelessness, and lack of access to good healthcare. All of these issues impact their overall health so much that it's hard to gather data on what their health outcomes would be if these issues weren't present." This was stunning-a group of people is treated so badly by our culture that we can't clearly study their health. The burden of this abuse is that substantial and pervasive. Your generation will be healthier. The signs are already there.

These genetic malfunctions are unlikely to produce schizophrenia in an individual unless they are stimulated by environmental conditions. By far the most causative environmental factor is stress, especially during gestation in the womb, early childhood, and adolescence—stages in which the brain is continually reshaping itself, and thus vulnerable to disruption. Stress can take the form of a person's enduring sustained anger, fear, or anxiety, or a combination of these. Stress works its damage by prompting an oversupply of cortisol, the normally life sustaining “stress hormone” that converts high energy glycogen to glucose in liver and in muscle tissue. Yet when it is called upon to contain a rush of glycogen, cortisol can transform itself into “Public Enemy Number One,” as one health advocate put it. The steroid hormone swells to flood levels and triggers weight gain, high blood pressure, heart disease, damage to the immune system, and an overflow of cholesterol. Stress is likely a trigger for schizophrenia.

In fact, several studies have shown that losing weight and exercising vigorously can sometimes actually reverse the disease, at least during its early stages. One extreme study placed eleven diabetics on a grueling ultra-low-calorie diet of just 600 calories per day for eight weeks. Six hundred calories is an extreme diet that would challenge most people (it’s about two tuna fish sandwiches a day). After two months, however, these seriously food-deprived diabetics had lost an average of 13 kilograms (27 pounds), mostly visceral fat, their pancreases doubled how much insulin they could produce, and they recovered nearly normal levels of insulin sensitivity.51 Vigorous physical activity also has potent reversal effects by causing your body to produce hormones (glucagon, cortisol, and others) that cause your liver, muscle, and fat cells to release energy. These hormones temporarily block the action of insulin while you exercise, and then they increase the sensitivity of these cells to insulin for up to sixteen hours following each bout of exercise.

The history of HRT use dates back to 1966 and the success of Dr. Robert Wilson’s best-selling book Feminine Forever, which he promoted vigorously. The premise of the book was that it was as natural and necessary for a menopausal woman to replace estrogen as it was for a diabetic to replace insulin. Dr. Wilson preached that doing so would keep a woman young, healthy, and attractive. He went so far as to declare that the lack of eggs and decline of reproductive hormones in a menopausal woman was a “galloping catastrophe”5 that could only be averted by taking estrogen supplements. He explained that with estrogen supplements, “Breasts and genital organs will not shrivel. Such women will be much more pleasant to live with and will not become dull and unattractive.” According to Dr. Wilson’s son, Ronald, all of his father’s expenses to write Feminine Forever were paid for by Wyeth-Ayerst, the maker of the synthetic estrogen supplement Premarin. He also said that Wyeth-Ayerst financed his father’s organization, the Wilson Research Foundation, which had offices on Park Avenue in Manhattan.

My general philosophy regarding endurance contains four key points: 1. Build a great aerobic base. This essential physical and metabolic foundation helps accomplish several important tasks: it prevents injury and maintains a balanced physical body; it increases fat burning for improved stamina, weight loss, and sustained energy; and it improves overall health in the immune and hormonal systems, the intestines and liver, and throughout the body. 2. Eat well. Specific foods influence the developing aerobic system, especially the foods consumed in the course of a typical day. Overall, diet can significantly influence your body’s physical, chemical, and mental state of fitness and health. 3. Reduce stress. Training and competition, combined with other lifestyle factors, can be stressful and adversely affect performance, cause injuries, and even lead to poor nutrition because they can disrupt the normal digestion and absorption of nutrients. 4. Improve brain function. The brain and entire nervous system control virtually all athletic activity, and a healthier brain produces a better athlete. Improved brain function occurs from eating well, controlling stress, and through sensory stimulation, which includes proper training and optimal breathing.

performance during PMS: Take 250 milligrams of magnesium, 45 milligrams of zinc, 80 milligrams of aspirin (baby aspirin), and 1 gram of omega-3 fatty acids (flaxseed and fish oil) each night for the 7 days before your period starts. Pretraining: Take 5 to 7 grams of branched-chain amino acid supplement (BCAAs) to fight the lack of mojo. These amino acids cross the blood-brain barrier and decrease the estrogen-progesterone effect on central nervous system fatigue. In training: Consume a few more carbohydrates per hour. In this high-hormone phase, aim for about 0.45 gram of carbohydrate per pound of body weight (about 61 grams for a 135-pound woman) per hour. In the low-hormone phase (first 2 weeks of the cycle), you can go a bit lower—about 0.35 gram of carbohydrate per pound of body weight (about 47 grams for a 135-pound woman) per hour. (For reference: 2.2 kilograms = 1 pound.) Post-training: Recovery is critical. Progesterone is extremely catabolic (breaks muscle down) and inhibits recovery. Aim to consume 20 to 25 grams of protein within 30 minutes of finishing your session. Overall you should aim to get 0.9 to 1 gram of protein per pound per day (a 135-pound woman needs about 122 to 135 grams of protein per day; see the Roar Daily Diet Cheat Sheet for Athletes for more information). THE MARTIAL ARTIST WHO BEAT HER BLOAT It may not be nice to fool Mother Nature, but there are definitely times when you need to trick her a little.

RESISTANCE TRAINING SHOULD HAVE BEEN INVENTED FOR WOMEN. The fitness industry has been plagued with more myths than ancient Greece. One of the most glaring is that women who weight train will look like Mr. Universe. There are still many women who are sidetracked by this common misperception, thereby avoiding weights altogether and bypassing the opportunity to achieve a beautiful, shapely body. One of the biggest differences between men and women is their hormone levels and how these hormones behave—most specifically, testosterone. Testosterone bulks up muscle mass in most men. Men have significantly higher testosterone levels than women, and therefore increasing muscle mass for men is much easier. The vast majority of women cannot build huge, bulging muscles because they have a tiny fraction of the testosterone found in men. There are so many benefits to resistance training for both men and women, but the some of the benefits are very specific to women’s health. For women, the truth is that resistance training increases your metabolism so that you burn fat more easily (and women tend to carry more body fat than men), you build bone mass and prevent osteoporosis (which affects more women than men), and you balance your hormones (which tend to fluctuate wildly in women as they age). Also, women who do resistance training feel a boost in self-esteem and gain renewed physical and mental strength because of their new sexy shape. Resistance training is a woman’s best friend. I rest my case.

As the pumping engines for the circulatory system, ventricles must have a particular ovoid, lemonlike shape for strong, swift ejection of blood. If the end of the left ventricle balloons out, as it does in takotsubo hearts, the firm, healthy contractions are reduced to inefficient spasms—floppy and unpredictable. But what’s remarkable about takotsubo is what causes the bulge. Seeing a loved one die. Being left at the altar or losing your life savings with a bad roll of the dice. Intense, painful emotions in the brain can set off alarming, life-threatening physical changes in the heart. This new diagnosis was proof of the powerful connection between heart and mind. Takotsubo cardiomyopathy confirmed a relationship many doctors had considered more metaphoric than diagnostic. As a clinical cardiologist, I needed to know how to recognize and treat takotsubo cardiomyopathy. But years before pursuing cardiology, I had completed a residency in psychiatry at the UCLA Neuropsychiatric Institute. Having also trained as a psychiatrist, I was captivated by this syndrome, which lay at the intersection of my two professional passions. That background put me in a unique position that day at the zoo. I reflexively placed the human phenomenon side by side with the animal one. Emotional trigger … surge of stress hormones … failing heart muscle … possible death. An unexpected “aha!” suddenly hit me. Takotsubo in humans and the heart effects of capture myopathy in animals were almost certainly related—perhaps even the same syndrome with different names.

It may seem paradoxical to claim that stress, a physiological mechanism vital to life, is a cause of illness. To resolve this apparent contradiction, we must differentiate between acute stress and chronic stress. Acute stress is the immediate, short-term body response to threat. Chronic stress is activation of the stress mechanisms over long periods of time when a person is exposed to stressors that cannot be escaped either because she does not recognize them or because she has no control over them. Discharges of nervous system, hormonal output and immune changes constitute the flight-or-fight reactions that help us survive immediate danger. These biological responses are adaptive in the emergencies for which nature designed them. But the same stress responses, triggered chronically and without resolution, produce harm and even permanent damage. Chronically high cortisol levels destroy tissue. Chronically elevated adrenalin levels raise the blood pressure and damage the heart. There is extensive documentation of the inhibiting effect of chronic stress on the immune system. In one study, the activity of immune cells called natural killer (NK) cells were compared in two groups: spousal caregivers of people with Alzheimer’s disease, and age- and health-matched controls. NK cells are front-line troops in the fight against infections and against cancer, having the capacity to attack invading micro-organisms and to destroy cells with malignant mutations. The NK cell functioning of the caregivers was significantly suppressed, even in those whose spouses had died as long as three years previously. The caregivers who reported lower levels of social support also showed the greatest depression in immune activity — just as the loneliest medical students had the most impaired immune systems under the stress of examinations. Another study of caregivers assessed the efficacy of immunization against influenza. In this study 80 per cent among the non-stressed control group developed immunity against the virus, but only 20 per cent of the Alzheimer caregivers were able to do so. The stress of unremitting caregiving inhibited the immune system and left people susceptible to influenza. Research has also shown stress-related delays in tissue repair. The wounds of Alzheimer caregivers took an average of nine days longer to heal than those of controls. Higher levels of stress cause higher cortisol output via the HPA axis, and cortisol inhibits the activity of the inflammatory cells involved in wound healing. Dental students had a wound deliberately inflicted on their hard palates while they were facing immunology exams and again during vacation. In all of them the wound healed more quickly in the summer. Under stress, their white blood cells produced less of a substance essential to healing. The oft-observed relationship between stress, impaired immunity and illness has given rise to the concept of “diseases of adaptation,” a phrase of Hans Selye’s. The flight-or-fight response, it is argued, was indispensable in an era when early human beings had to confront a natural world of predators and other dangers. In civilized society, however, the flight-fight reaction is triggered in situations where it is neither necessary nor helpful, since we no longer face the same mortal threats to existence. The body’s physiological stress mechanisms are often triggered inappropriately, leading to disease. There is another way to look at it. The flight-or-fight alarm reaction exists today for the same purpose evolution originally assigned to it: to enable us to survive. What has happened is that we have lost touch with the gut feelings designed to be our warning system. The body mounts a stress response, but the mind is unaware of the threat. We keep ourselves in physiologically stressful situations, with only a dim awareness of distress or no awareness at all.

The traditional hospital practice of excluding parents ignored the importance of attachment relationships as regulators of the child’s emotions, behaviour and physiology. The child’s biological status would be vastly different under the circumstances of parental presence or absence. Her neurochemical output, the electrical activity in her brain’s emotional centres, her heart rate, blood pressure and the serum levels of the various hormones related to stress would all vary significantly. Life is possible only within certain well-defined limits, internal or external. We can no more survive, say, high sugar levels in our bloodstream than we can withstand high levels of radiation emanating from a nuclear explosion. The role of self-regulation, whether emotional or physical, may be likened to that of a thermostat ensuring that the temperature in a home remains constant despite the extremes of weather conditions outside. When the environment becomes too cold, the heating system is switched on. If the air becomes overheated, the air conditioner begins to work. In the animal kingdom, self-regulation is illustrated by the capacity of the warm-blooded creature to exist in a broad range of environments. It can survive more extreme variations of hot and cold without either chilling or overheating than can a coldblooded species. The latter is restricted to a much narrower range of habitats because it does not have the capacity to self-regulate the internal environment. Children and infant animals have virtually no capacity for biological self-regulation; their internal biological states—heart rates, hormone levels, nervous system activity — depend completely on their relationships with caregiving grown-ups. Emotions such as love, fear or anger serve the needs of protecting the self while maintaining essential relationships with parents and other caregivers. Psychological stress is whatever threatens the young creature’s perception of a safe relationship with the adults, because any disruption in the relationship will cause turbulence in the internal milieu. Emotional and social relationships remain important biological influences beyond childhood. “Independent self-regulation may not exist even in adulthood,” Dr. Myron Hofer, then of the Departments of Psychiatry and Neuroscience at Albert Einstein College of Medicine in New York, wrote in 1984. “Social interactions may continue to play an important role in the everyday regulation of internal biologic systems throughout life.” Our biological response to environmental challenge is profoundly influenced by the context and by the set of relationships that connect us with other human beings. As one prominent researcher has expressed it most aptly, “Adaptation does not occur wholly within the individual.” Human beings as a species did not evolve as solitary creatures but as social animals whose survival was contingent on powerful emotional connections with family and tribe. Social and emotional connections are an integral part of our neurological and chemical makeup. We all know this from the daily experience of dramatic physiological shifts in our bodies as we interact with others. “You’ve burnt the toast again,” evokes markedly different bodily responses from us, depending on whether it is shouted in anger or said with a smile. When one considers our evolutionary history and the scientific evidence at hand, it is absurd even to imagine that health and disease could ever be understood in isolation from our psychoemotional networks. “The basic premise is that, like other social animals, human physiologic homeostasis and ultimate health status are influenced not only by the physical environment but also by the social environment.” From such a biopsychosocial perspective, individual biology, psychological functioning and interpersonal and social relationships work together, each influencing the other.

REPROGRAMMING MY BIOCHEMISTRY A common attitude is that taking substances other than food, such as supplements and medications, should be a last resort, something one takes only to address overt problems. Terry and I believe strongly that this is a bad strategy, particularly as one approaches middle age and beyond. Our philosophy is to embrace the unique opportunity we have at this time and place to expand our longevity and human potential. In keeping with this health philosophy, I am very active in reprogramming my biochemistry. Overall, I am quite satisfied with the dozens of blood levels I routinely test. My biochemical profile has steadily improved during the years that I have done this. For boosting antioxidant levels and for general health, I take a comprehensive vitamin-and-mineral combination, alpha lipoic acid, coenzyme Q10, grapeseed extract, resveratrol, bilberry extract, lycopene, silymarin (milk thistle), conjugated linoleic acid, lecithin, evening primrose oil (omega-6 essential fatty acids), n-acetyl-cysteine, ginger, garlic, l-carnitine, pyridoxal-5-phosphate, and echinacea. I also take Chinese herbs prescribed by Dr. Glenn Rothfeld. For reducing insulin resistance and overcoming my type 2 diabetes, I take chromium, metformin (a powerful anti-aging medication that decreases insulin resistance and which we recommend everyone over 50 consider taking), and gymnema sylvestra. To improve LDL and HDL cholesterol levels, I take policosanol, gugulipid, plant sterols, niacin, oat bran, grapefruit powder, psyllium, lecithin, and Lipitor. To improve blood vessel health, I take arginine, trimethylglycine, and choline. To decrease blood viscosity, I take a daily baby aspirin and lumbrokinase, a natural anti-fibrinolytic agent. Although my CRP (the screening test for inflammation in the body) is very low, I reduce inflammation by taking EPA/DHA (omega-3 essential fatty acids) and curcumin. I have dramatically reduced my homocysteine level by taking folic acid, B6, and trimethylglycine (TMG), and intrinsic factor to improve methylation. I have a B12 shot once a week and take a daily B12 sublingual. Several of my intravenous therapies improve my body’s detoxification: weekly EDTA (for chelating heavy metals, a major source of aging) and monthly DMPS (to chelate mercury). I also take n-acetyl-l-carnitine orally. I take weekly intravenous vitamins and alpha lipoic acid to boost antioxidants. I do a weekly glutathione IV to boost liver health. Perhaps the most important intravenous therapy I do is a weekly phosphatidylcholine (PtC) IV, which rejuvenates all of the body’s tissues by restoring youthful cell membranes. I also take PtC orally each day, and I supplement my hormone levels with DHEA and testosterone. I take I-3-C (indole-3-carbinol), chrysin, nettle, ginger, and herbs to reduce conversion of testosterone into estrogen. I take a saw palmetto complex for prostate health. For stress management, I take l-theonine (the calming substance in green tea), beta sitosterol, phosphatidylserine, and green tea supplements, in addition to drinking 8 to 10 cups of green tea itself. At bedtime, to aid with sleep, I take GABA (a gentle, calming neuro-transmitter) and sublingual melatonin. For brain health, I take acetyl-l-carnitine, vinpocetine, phosphatidylserine, ginkgo biloba, glycerylphosphorylcholine, nextrutine, and quercetin. For eye health, I take lutein and bilberry extract. For skin health, I use an antioxidant skin cream on my face, neck, and hands each day. For digestive health, I take betaine HCL, pepsin, gentian root, peppermint, acidophilus bifodobacter, fructooligosaccharides, fish proteins, l-glutamine, and n-acetyl-d-glucosamine. To inhibit the creation of advanced glycosylated end products (AGEs), a key aging process, I take n-acetyl-carnitine, carnosine, alpha lipoic acid, and quercetin. MAINTAINING A POSITIVE “HEALTH SLOPE” Most important,

specific foods such as yogurt, as well as calcium-rich foods, omega-3 fats in fish, and whole grains truly do trim your belly fat, thanks to their effect on hormones and metabolism.

Finally, thoughts also have an impact on your physical health. The subconscious mind tells the body what to do, how to feel, and which chemicals to create. When the subconscious mind converts a negative thought into fear and stress, the body produces the stress hormone cortisol. Over time, production of this hormone can lead to heart disease and digestive issues.

The physiology of inactivity theory suggests that prolonged sitting also causes weight gain by creating imbalances in critical metabolic hormones such as leptin, which regulates appetite and fat metabolism in the body. When leptin signaling is compromised, your brain will crave more food, and your body will default into a fat-storage hormonal pattern instead of a fat-burning hormonal pattern.17 All this has scientists and members of the medical community repeating the same tagline: sitting is the new smoking.

Probiotics—These help maintain healthy intestinal flora and healthy estrogen levels. Make sure you get human-strain probiotics that have live cultures. Consider taking 10–60 billion units per day. Plant Phytoestrogens—These plant-based compounds have healthy estrogen-like activity and have been found helpful for a variety of conditions, including menopausal symptoms, PMS, and endometriosis. Phytoestrogens can be found in soy, kudzu, red clover, and pomegranate. Resveratrol is a bioflavonoid antioxidant that occurs naturally in grapes and red wine and has been reported to inhibit breast cancer cell growth in laboratory studies. Black cohosh—This herb has been used for centuries by Native Americans for hormonal balance in women.

During the worst time of Jesse’s cycle, the “worry” region of her brain was overactive, which caused her to become fixated on things, and the judgment and impulse control part of her brain was underactive. The alcohol likely further dropped her ability to control her behavior. That’s why she was so distraught with her husband and why the idea of grabbing the knife wasn’t properly processed and filtered out. During the best time of her cycle, Jesse’s brain was much more balanced. The answer to this woman’s problem was not just anger-management therapy. It was to get her hormonal fluctuations under control. During the days prior to starting your period, estrogen and progesterone levels hit rock bottom. On scans, I see the worry center of the brain (the anterior cingulate gyrus) start to fire up; as a result, women can get stuck on negative thoughts or give in to behaviors they think will make them feel better, such as reaching for wine or cookies.

Estradiol—Estradiol is the strongest estrogen; it helps you think clearly. It is produced in the ovaries and has many protective effects, including maintaining bone density, improving growth hormone production and cardiovascular function, keeping your blood from getting “sticky,” supporting cognitive function and mood, assisting in growth hormone release, and improving your lipids profile. Too much estradiol can be associated with estrogen-related cancers, but deficiencies can lead to osteoporosis, heart disease, dementia, and other diseases of aging. Estradiol keeps you looking and feeling young and vibrant. It also provides antiaging protection for the skin. And it even helps prevent weight gain. Researchers at Yale University have found that estradiol suppresses appetite using the same pathways in the brain as leptin, which is one of the hormones that regulate appetite.

Dietary Changes to Improve the 2:16 Ratio There are great foods that can help improve the conversion of estrogen into good metabolites and away from the bad ones. These foods include insoluble dietary fibers, such as lignin found in green beans, peas, carrots, seeds, and Brazil nuts. The reason that dietary fiber, especially lignin, is so beneficial is that it can bind harmful estrogens in the digestive tract, so they can be excreted in the feces instead of being reabsorbed. Dietary fiber also improves the composition of intestinal bacteria so that harmful estrogen metabolites can be excreted from the body. It also decreases the conversion of testosterone into estrogens, maintaining a healthy testosterone level. Sugar and simple carbohydrates cause unfriendly flora to grow in the gastrointestinal tract and disrupt estrogen metabolism. These foods also raise blood sugar and insulin levels, resulting in adverse influences in sex hormone balance. Too many simple carbohydrates have been associated with postmenopausal breast cancer risk among overweight women and women with a large waist

In a young, healthy woman, the estrogen ratio generally averages as follows: 60–80 percent estriol, 10–20 percent estradiol, and 10–20 percent estrone. While these levels vary from one individual to another, the goal of bioidentical hormone restoration therapy (BHRT), discussed later, is to re-create a more natural balance in the levels of estrogen and in combination with all the other sex hormones. Estrogens convert into several metabolites. Estrone, for example, may convert into three different forms: • 2-hydroxyestrone, protective against cancer • 4-hydroxyestrone, promotes cancer • 16-alpha-hydroxyestrone, promotes cancer

Healthy levels of estrogen help you feel good. Too much estrogen can make you feel as anxious and irritable as a wet cat. Estrogen withdrawal makes you feel depressed and confused. It’s the rise and drop in estrogen that drastically affects your mood, and the more erratic your particular fluctuation is, the more upset it can make you. These problems become worse during perimenopause and menopause, when estrogen levels wane. There are three different kinds of estrogen: estrone (oestrone), estradiol (oestradiol), and estriol (oestriol). According to my friend and colleague Dr. James LaValle, author of the Metabolic Code, estrone is the estrogen to worry about. Estrone can make you more prone to cancer. Your liver, gut, and adrenal health determine what types of hormones are made. Depending

Estriol—Estriol is the weakest of the three estrogens and has a protective role in breast tissue. It is believed to protect vaginal tissue too. Estriol helps to reduce hot flashes in women, protects the urinary tract, and plays a role in retention of bone density. It can help increase “good” HDL and decrease “bad” LDL cholesterol. One compelling study showed that taking estriol can reverse brain lesions in women with multiple sclerosis. Estrogen is particularly needed in women to make serotonin function at its best in the brain. Serotonin is one of the brain’s feel-good hormones. With no estrogen, your mood can change to anxious and depressed. Cognitive functions, such as critical thinking and short-term memory, are also eroded with the loss of estrogen production. Below is a list of symptoms related to low and high estrogen levels:

have been associated with obesity, depression, cognitive impairment, heart disease, reduced immunity, cancer, psychosis, and all causes of mortality. Check your 25-hydroxy vitamin D level, and if it is low, try to get more sunshine in a safe way and/or take a vitamin D3 supplement. A healthy vitamin D level is between 75 and 250 nmol/L (nanograms per liter). Optimal is between 125 and 250 nmol/L. Personally, I never wanted to be in the bottom of any class I was ever in. Two-thirds of the population are low in vitamin D; this is the same percentage of U.S. residents who are overweight or obese. According to one study, when vitamin D is low the hormone leptin that tells us to stop eating is not effective. One

There are hundreds of hormones in the body that affect the brain. To keep it practical, I am going to show you how to optimize seven of your most important hormones: • Estrogen • Progesterone • Testosterone • Thyroid • Cortisol • DHEA • Insulin

sleeplessness, anxiety, irritability, racing thoughts, a fast pulse, breathlessness, weight loss despite an increased appetite, feeling too hot for no clear reason, and always feeling as though somebody set the thermostat too high, you could have an overactive thyroid. In extreme cases, you might see the classic systems of a goiter (a growth on the thyroid), weight loss, bulging eyes, and an intense staring gaze. Your thyroid is a small butterfly-shaped gland located in your lower neck. When your doctor runs her hands along the base of your throat, she’s checking to see if there are any noticeable problems with the size of your thyroid. But you can’t really tell what’s going on without a blood test. And it can take some adjusting to get your thyroid optimized. The main thyroid hormones—TSH, T3, and T4—all have to be in the right balance. It is estimated that tens of millions of people worldwide (5–25 percent of the world’s population) have thyroid problems. Thyroid problems are more common as we age and they seem to be increasing in the population.

Unbalanced and low levels of hormones have been associated with numerous chronic problems and age-related conditions. Along with many other actions, hormones are chemical messengers; they signal the cells to become younger or older, to slow or increase multiplication, to be immunologically responsive or lazy.