High Metabolism Quotes

After a fairly shaky start to the day, Arthur's mind was beginning to reassemble itself from the shell-shocked fragments the previous day had left him with. He had found a Nutri-Matic machine which had provided him with a plastic cup filled with a liquid that was almost, but not quite, entirely unlike tea. The way it functioned was very interesting. When the Drink button was pressed it made an instant but highly detailed examination of the subject's taste buds, a spectroscopic analysis of the subject's metabolism and then sent tiny experimental signals down the neural pathways to the taste centers of the subject's brain to see what was likely to go down well. However, no one knew quite why it did this because it invariably delivered a cupful of liquid that was almost, but not quite, entirely unlike tea.

Organic Oreos are not a health food. When Coca-Cola begins selling organic Coke, as it surely will, the company will have struck a blow for the environment perhaps, but not for our health. Most consumers automatically assume that the word "organic" is synomymous with health, but it makes no difference to your insulin metabolism if the high-fructose corn syrup in your soda is organic.

In the early 1900s, researhers first posited the idea that longevity is inversely related to metabolic rate. They called it the “rate of living.” In other words, if you consistently burn energy at a high rate, you will quickly burn out.

High quality sleep fortifies your immune system, balances your hormones, boosts your metabolism, increases physical energy, and improves the function of your brain.

You’d think I’d be larger, but my theory is that the internal nervous energy I work so hard to conceal keeps my metabolism running on high.

He had found a Nutri-Matic machine which had provided him with a plastic cup filled with a liquid that was almost, but not quite, entirely unlike tea. The way it functioned was very interesting. When the Drink button was pressed it made an instant but highly detailed examination of the subject’s taste buds, a spectroscopic analysis of the subject’s metabolism and then sent tiny experimental signals down the neural pathways to the taste centers of the subject’s brain to see what was likely to go down well. However, no one knew quite why it did this because it invariable delivered a cupful of liquid that was almost, but not quite, entirely unlike tea. The Nutri-Matic was designed and manufactured by the Sirius Cybernetics Corporation whose complaint department now covers all the major landmasses of the first three planets in the Sirius Tau Star system.

Because consistently high insulin levels are the root cause of all the diseases of metabolic syndrome, it’s especially important for those with metabolic syndrome to consider how foods stimulate the release of insulin.

By shifting to a highly digestible, cooked diet, our forebears no longer needed the massive molars and expansive guts that apes need to process fibrous raw foods. And with so much more energy available, we could suddenly afford the metabolic demands of a larger brain.

Nothing breaks my heart more than seeing that person who’s struggling to lose weight who thinks that they need to run 20 miles a week. They have no desire to do it, their knees hurt, they hate it, and they’re not losing weight. And I’d like to say, ‘Well, I’ve got great news for you. You don’t ever need to run another step a day in your life, because there’s no value in that.’ “There is value in exercise, though, and I think that the most important type of exercise, especially in terms of bang for your buck, is going to be really high-intensity, heavy strength training. Strength training aids everything from glucose disposal and metabolic health to mitochondrial density and orthopedic stability. That last one might not mean much when you’re a 30-something young buck, but when you’re in your 70s, that’s the difference between a broken hip and a walk in the park.

The difference between survival and reproduction is shown with “antagonistic pleiotropy,” referring to traits that increase reproductive fitness early in life yet decrease life span. For example, primates’ prostates have high metabolic rates, enhancing sperm motility. Upside: enhanced fertility; downside: increased risk of prostate cancer. Antagonistic pleiotropy occurs dramatically in salmon, who epically journey to their spawning grounds to reproduce and then die. If evolution were about survival rather than passing on copies of genes, there’d be no antagonistic pleiotropy.2

When the Drink button was pressed it made an instant but highly detailed examination of the subject’s taste buds, a spectroscopic analysis of the subject’s metabolism and then sent tiny experimental signals down the neural pathways to the taste centers of the subject’s brain to see what was likely to go down well.

Astwood’s belief that those who fatten easily are fundamentally, physiologically and metabolically different from those who don’t. This implies that those of us who fatten easily can get fat on precisely the same food and even the same amount on which lean people stay lean. We can’t be told to eat like lean and healthy people eat and expect that advice to work, because we get fat eating like lean and healthy people. Indeed, we get fat and hungry eating like lean and healthy people do.

Most processed foods and ingredients are low in protein, high in carbs, high in fat, and engineered to increase palatability. They’re literally designed by scientists to make you overeat because you’re not getting enough protein for satiety, no micronutrients, and way too many over-stimulating sugars and other ingredients that make you lose your sanity.

department store, but because your body requires high-quality nutrients

Steer clear of sugars in any form (including starchy carbohydrates) because they can be disruptive to the way you process and metabolize foods.

Your body will not burn fat while your insulin level is high. It’s focused on using glucose. But once all of the glucose and glycogen is used, the insulin level falls

Cheap food tends to be highly-refined and layered with sugar, like the Frosted Flakes described previously. Sugar in all its forms has a direct effect on the dopamine response as we determined.

Athletes who overuse high-intensity training methods will usually have a low AeT because their aerobic metabolism has become detrained while the anaerobic metabolic pathway has become very powerful.

board, and as the law of energy balance dictates, you’ll still lose weight. But if you hold the protein steady, or even increase the protein, it’s more likely that all the weight you lose will be fat. Maintaining muscle isn’t the only advantage: Protein also suppresses hunger and increases metabolism more than any other macronutrient. That makes three major advantages to keeping protein high when calories are low.

Looking at obesity without preconceived ideas,” she wrote, “one would assume that the main trend of research should be directed toward an examination of abnormalities of the fat metabolism, since by definition excessive accumulation of fat is the underlying abnormality. It so happens that this is the area in which the least work has been done.” She added, “As long as it was not known how the body builds up and breaks down its fat deposit, the ignorance was glossed over by simply stating that food taken in excess of body needs was stored and deposited in the fat cells, the way potatoes are put into a bag. Obviously, this is not so.

First, when you try to restrict calories and exercise more, your body is hardwired to perceive a starvation situation. That makes you tired (so you move less and conserve energy) and hungry (so you eat more), and it slows down your metabolism (so you don’t die!). This “eat less, exercise more” formula is not too successful for most people. It can work for a short time, certainly, but less than 10 percent of people lose weight and keep it off for a year;4 you will almost always rebound and gain back the weight. Second, when you eat carbs and sugar, insulin spikes and your blood sugar drops. The insulin drives most of the available fuel in your bloodstream into fat cells, especially the fat cells around your middle, otherwise known as belly fat. So your body is starved of fuel, and this stimulates your brain5 to make you eat more.6 You could have a year’s worth of stored energy in your fat tissue and yet feel like you are starving. The only thing that can stop this vicious cycle is eating a lot of fat and cutting out the refined carbs and sugar. A high-fat, low-carb diet leads to a faster metabolism and sustained weight loss.

The metabolic rate of history is too fast for us to observe it. It's as if, attending to the day-long life cycle of a single mayfly, we lose sight of the species and its fate. At the same time, the metabolic rate of geology is too slow for us to perceive it, so that, from birth to death, it seems to us who are caught in the beat of our own individual human hearts that everything happening on this planet is what happens to us, personally, privately, secretly. We can stand at night on a high, cold plain and look out toward the scrabbled, snow-covered mountains in the west, the same in a suburb of Denver as outside a village in Baluchistan in Pakistan, and even though beneath our feet continent-sized chunks of earth grind inexorably against one another, go on driving one or the other continent down so as to rise up and over it, as if desiring to replace it on the map, we poke with our tongue for a piece of meat caught between two back teeth and think of sarcastic remarks we should have made to our brother-in-law at dinner.

Through the eyes of a high-flying night bird, we take in the scene from midair. In our broad sweep, the city looks like a single gigantic creature--or more like a single collective entity created by many intertwining organisms. Countless arteries stretch to the ends of its elusive body, circulating a continuous supply of fresh blood cells, sending out new data and collecting the old, sending out new consumables and collecting the old, sending out new contradictions and collecting the old. To the rhythm of its pulsing, all parts of the body flicker and flare up and squirm. Midnight is approaching, and while the peak of activity has passed, the basal metabolism that maintains the life continues undiminished, producing the bass continuo of the city's moan, a monotonous sound the neither rises nor falls but is pregnant with foreboding.

Man's body was designed to function best with high blood and cellular levels of vitamin C - synthesised as needed by the liver. Due to an inborn error of metabolism, the vast majority of us no longer have the ability to make it, but that does not lessen our need for vitamin C or the benefits derived form it.

If you're going to be my Valentine then I expect chocolates. Lots of them." He'd already planned to get her some considering how much the female ate chocolate. She was tall and slender and her high shifter metabolism meant she was often eating something sweet. He wondered if she'd taste sweet when he kissed her.

Dietary fat was singled out as the most villainous culprit responsible for weight gain and declining health. The food industry adjusted by replacing saturated animal fats with “heart healthy,” super-processed vegetable seed oils, and high fructose corn syrup. Soon, our average body weight started to rise, and it did so quickly.

Methionine is also an essential amino acid needed for growth and development. However, when it comes to longevity in life, research has found that rats eating a methionine-restrictive diet lived 43-percent longer than those that consume a diet high in methionine. Methionine is known for its thyroid-suppressing properties like cysteine

These visceral (belly) fat cells behave differently than fat elsewhere in the body in two important ways.25 First, they are several times more sensitive to hormones and thus tend to be more metabolically active, which means they are capable of storing and releasing fat more rapidly than fat cells in other parts of the body. Second, when visceral cells release fatty acids (something fat cells do all the time), they dump the molecules almost straight into the liver, where the fat accumulates and eventually impairs the liver’s ability to regulate the release of glucose into the blood. An excess of belly fat (a paunch) is therefore a much greater risk factor for metabolic disease than a high BMI.

Today we call this cluster of problems “metabolic syndrome” (or MetSyn), and it is defined in terms of the following five criteria: high blood pressure (>130/85) high triglycerides (>150 mg/dL) low HDL cholesterol (<40 mg/dL in men or <50 mg/dL in women) central adiposity (waist circumference >40 inches in men or >35 in women) elevated fasting glucose (>110 mg/dL)

The biological anthropologist Stephen McGarvey has speculated that the people who survived these voyages tended to have a higher percentage of body fat before the voyage began and/or more efficient metabolisms, allowing them to live longer on less food than their thinner companions. (McGarvey theorizes that this is why modern-day Polynesians suffer from a high incidence of obesity.)

Parents recognize this as the “sugar high,” but it’s actually the negative feedback system of energy balance at work. The cookie stimulated insulin release, which drove energy into fat tissue, which released leptin, which reached the hypothalamus, which activated the sympathetic nervous system, which led to increased energy expenditure, including involuntary contraction of muscles, aka fidgeting—all to maintain energy neutrality.

While genetics play a significant role, so too, does experience, for running (and especially running long distances) has a high metabolic cost. The dogs’ muscles must be strong, but most of all, they must be efficient. The ability to run fast and consistently for long periods of time depends on the body’s ability to provide adequate energy to working muscles and to efficiently remove waste products such as carbon dioxide and lactic acid. In both humans and dogs, only about a quarter of the energy from the breakdown of fats and carbohydrates in food is converted into mechanical energy; the rest is dissipated as heat. The primary focus of training for a race—for both humans and canines—is teaching the body to get better at converting available energy from glucose, carbohydrates, fats, and proteins into energy. This can only really be achieved through regular exercise

This is the science behind how UPF affects the human body: • The destruction of the food matrix by physical, chemical and thermal processing means that UPF is, in general, soft. This means you eat it fast, which means you eat far more calories per minute and don’t feel full until long after you’ve finished. It also potentially reduces facial bone size and bone density, leading to dental problems. • UPF typically has a very high calorie density because it’s dry, and high in fat and sugar and low in fibre, so you get more calories per mouthful. • It displaces diverse whole foods from the diet, especially among low-income groups. And UPF itself is often micronutrient-deficient, which may also contribute to excess consumption. • The mismatch between the taste signals from the mouth and the nutrition content in some UPF alters metabolism and appetite in ways that we are only beginning to understand, but that seem to drive excess consumption. • UPF is addictive, meaning that for some people binges are unavoidable. • The emulsifiers, preservatives, modified starches and other additives damage the microbiome, which could allow inflammatory bacteria to flourish and cause the gut to leak. • The convenience, price and marketing of UPF urge us to eat constantly and without thought, which leads to more snacking, less chewing, faster eating, increased consumption and tooth decay. • The additives and physical processing mean that UPF affects our satiety system directly. Other additives may affect brain and endocrine function, and plastics from the packaging might affect fertility. • The production methods used to make UPF require expensive subsidy and drive environmental destruction, carbon emissions and plastic pollution, which harm us all.

Meat consumption is at an all-time high. In 2000, we ate 195 pounds per person, and that’s 57 more pounds more than in the 1950s. Even though I think of meat eaters as being mainly men… it’s fascinating to me how modern meat is the food that disturbs estrogen balance the most. Since women have far more estrogen than men, that means we’re more vulnerable to the effects of meat and alcohol, which raise estrogen. (Too much estrogen makes you fat.)

nonalcoholic fatty liver disease has become the most common chronic liver disease in the world, increasing from 25 percent of the global population in 1990 to close to 40 percent by 2019. NAFLD is full-blown metabolic dysfunction in kids and adults, representing liver cells filling with fat, which worsens insulin resistance. Key contributors are processed foods, refined sugars, refined grains, sweet beverages, high-fructose corn syrup, fast food, low fiber and phytochemical intake, habitual eating close to bedtime, sedentary behavior, and oxidative stress. Liver transplants have gone up close to 50 percent in the past fifteen years, and while alcohol and hepatitis C used to be the leading causes, now NAFLD is taking the lead in women as the cause of liver failure and is a top cause for men. Fatty liver disease is now the most common cause of liver transplant in young adults in the United States. We are failing our children.

Our body is like a machine. If we constantly run the machinery at high speed, it will wear out faster. Since animals with slower metabolic rates live longer, eating more calories, which drives up our metabolic rate, will cause us only to age faster. Contrary to what you may have heard and read in the past, our goal should be the opposite: to eat less, only as much as we need to maintain a slim and muscular weight, and no more, so as to keep our metabolic rate relatively slow.

Since 2005, researchers have been finding correlations between diabetes and risk for Alzheimer’s disease, especially when the diabetes is not controlled and a person suffers from chronic high blood sugar.7 Some have gone so far as to refer to Alzheimer’s disease as “type 3 diabetes,” because the disease often involves a disrupted relationship with insulin, the metabolic hormone involved in both types 1 and 2 diabetes. Insulin is the hormone needed to deliver sugar (glucose) into cells for use.

There’s a saying that insanity is doing the same thing over and over and expecting different results. And that’s precisely what has happened to national nutritional policy in the United States in recent years. The government ignores studies that don’t fit within a preconceived template of a low-fat, low-salt, calorie-restricted, high-carb, plant-based diet. But this one-size-fits-all approach to eating does not work for the large segment of the population that is dealing with obesity and other metabolic chronic health issues.

With food we covered three simple rules that get you quite far: don't eat added sugar, don't eat industrially processed vegetable and seed oils, and don't eat highly processed grains. With fitness I also suggest three simple rules: 1. walk at least 7,000 steps throughout the day and space them out throughout the day; work up to 1,000 per day; 2. get your heart rate above 60% of your maximum for at least 150 minutes per week (30 minutes for 5 days per week). 3. lift heavy things multiple times per week in a way that hits every major muscle group.

Below are recommended optimal ranges for key metabolic blood tests. Falling outside of these ranges is an indicator that you could have brewing dysfunction. The remainder of Part 2 and the plan in Part 3 will give specific steps to increase Good Energy and improve these biomarkers: Triglycerides: Less than 80 mg/dL HDL: 50 to 90 mg/dL Fasting Glucose: 70 to 85 mg/dL Blood Pressure: Less than 120 systolic and less than 80 diastolic mmHg Waist Circumference: <80 cm (31.5 inches) for women and <90 cm (35 inches) for men (South Asian, Chinese, Japanese, and South and Central Americans) <80 cm (31.5 inches) for women and <94 cm (37 inches) for men (European, Sub-Saharan African, Middle Eastern, and Eastern Mediterranean) Triglyceride-to-HDL Ratio: Below 1.5. Above 3 is a clear sign of metabolic dysfunction. Fasting Insulin: From 2 to 5 mIU/L. Above 10 mIU/L is concerning and above 15 mIU/L is significantly elevated. HOMA-IR: Less than 2.0 High-Sensitivity CRP (hsCRP): Less than 0.3 mg/dL Hemoglobin A1c: From 5.0 to 5.4 percent Uric Acid: Less than 5 mg/dL for men, and from 2 to 4 mg/dL for women

About 74 percent of U.S. adults are overweight or obese, and 93.2 percent have metabolic dysfunction. These numbers sound high until you realize how many levers of modern society are stacked against our mitochondria and metabolism: too much sugar, too much stress, too much sitting, too much pollution, too many pills, too many pesticides, too many screens, too little sleep, and too little micronutrients. These trends—with trillions of dollars behind them—are causing epidemic levels of mitochondrial dysfunction and underpowered, sick, inflamed bodies.

Many factors other than your size, fat, and muscle tissue figure in resting metabolism. Some are genetic and immutable. You may have been born with the ability to burn a lot of energy quickly and effortlessly, while others have what’s called a “sluggish metabolism”and don’t use energy at a very fast rate. It’s interesting to consider the cultural value judgment in using the term “sluggish”; from a scientific perspective, the person with a slower metabolism is much more efficient, a trait that would have been highly prized in earlier times when food was harder to come by.

He had found a Nutri-Matic machine which had provided him with a plastic cup filled with a liquid that was almost, but not quite, entirely unlike tea. The way it functioned was very interesting. When the Drink button was pressed it made an instant but highly detailed examination of the subject’s taste buds, a spectroscopic analysis of the subject’s metabolism and then sent tiny experimental signals down the neural pathways to the taste centers of the subject’s brain to see what was likely to go down well. However, no one knew quite why it did this because it invariably delivered a cupful of liquid that was almost, but not quite, entirely unlike tea.

Simple markers can show us “check engine” alerts. A most basic and accessible way to see if you have a reasonable level of metabolic health is by checking five markers that are almost always tested and tracked at your annual checkup: blood sugar, triglycerides, high-density lipoprotein (HDL) cholesterol, blood pressure, and waist circumference. When these markers fall into an optimal range, in the absence of medication—see Chapter 4 for exact specifications—you can deduce that your cellular energy production is doing OK. Typically, you will feel vibrant, healthy, and pain-free. These feelings, too, should tell you that your body has Good Energy, the foundation of general good health.

Dose response studies indicate a linear increase in skeletal muscle protein synthesis with ingestion of high quality protein up to about 20-25 grams per meal[127]. With protein intakes twice this amount, there is a marked increase in protein oxidation with no further increase in protein synthesis. When looked at over the course of a day, there is no credible evidence that protein intakes above 2.5 g/kg body weight lead to greater nitrogen balance or accumulation of lean tissue. Another reason to avoid eating too much protein is that it has a modest insulin stimulating effect that reduces ketone production. While this effect is much less gram-for-gram than carbohydrates, higher protein intakes reduce one’s keto-adaptation and thus the metabolic benefits of the diet.

Refined Added Sugar Refined added sugar causes astronomically more deaths and disability per year than COVID-19 and fentanyl overdoses combined. We need to see refined added sugar for what it is: an addictive, dangerous drug that has been included in 74 percent of foods in the U.S. food system and for which the body needs zero grams in a lifetime. Of all the levers most damaging our cells and preventing Good Energy, I believe the worst offender may be added sugar. This substance has become a mainstay of food that we and our children eat regularly. As Dr. Robert Lustig has noted, sugar shows up on labels in fifty-six different names and sneaks in everywhere. While dozens of types of refined sugar are added to foods, chief among the offenders is high-fructose corn syrup,

Another example is tamoxifen, which is used for treatment of endocrine responsive breast cancer. Tamoxifen is given to patients postsurgery and dramatically reduces the rate of cancer recurrence. This drug is metabolized by cytochrome P450 2D6, the product of the CYP2D6 gene. Based on their DNA, there are patients with little CYP2D6 activity who are poor metabolizers and others with high activity who are extensive metabolizers. An FDA-approved genetic test exists for finding the variants of the CYP2D6 gene to help guide tamoxifen administration, but the lack of study data demonstrating its role in improving patient outcomes has, to date, led insurance companies to refuse to cover the test. Beyond having ramifications for drug efficacy, genetics also may play a role in the side effects of drugs.

Triglyceride-to-HDL Ratio After assessing each of these five biomarkers, there is one more step: calculate your triglyceride-to-HDL ratio to better understand insulin sensitivity. Simply divide your triglycerides by your HDL. Interestingly, studies have shown that this value correlates well with underlying insulin resistance. So even if you are unable to access a fasting insulin test, the triglyceride-to-HDL ratio can give you a general sense of where you’re at. According to Dr. Mark Hyman, “the triglyceride-to-HDL ratio is the best way to check for insulin resistance other than the insulin response test. According to a paper published in Circulation, the most powerful test to predict your risk of a heart attack is the ratio of your triglycerides to HDL. If the ratio is high, your risk for a heart attack increases sixteen-fold—or 1,600 percent! This is because triglycerides go up and HDL (or ‘good cholesterol’) goes down with diabesity.” Dr. Robert Lustig agrees: “The triglyceride-to-HDL ratio is the best biomarker of cardiovascular disease and the best surrogate marker of insulin resistance and metabolic syndrome.” In children, higher triglyceride-to-HDL is significantly correlated with mean insulin, waist circumferences, and insulin resistance. In adults, the ratio has shown a positive association with insulin resistance across normal weight and overweight people and significantly tracks with insulin levels, insulin sensitivity, and prediabetes. Perplexingly, the triglyceride-to-HDL ratio is not a metric used in standard clinical practice. If you remember one thing from this chapter, remember this: you need to know your insulin sensitivity. It can give you lifesaving clues about early dysfunction and Bad Energy brewing in your body, and is best assessed by a fasting insulin test, discussed below. Right now, this is not a standard test offered to you at your annual physical. I implore you to find a way to get a fasting insulin test or to calculate your triglyceride-to-HDL ratio every year. Do this for your children, as well. And take the steps outlined in the following chapters to ensure it does not start creeping up. RANGES: Range considered “normal” by standard criteria: none specified in standard criteria Optimal range: Anything above a ratio of 3 is strongly suggestive of insulin resistance. You want to shoot for less than 1.5, although lower is better. I recommend aiming for less than 1.

The ingestion of carbohydrates, especially the refined grains and sugars that are so prominent in the modern diet, causes a spike in blood sugar and a temporary energy boost. Then, because a glucose overdose is toxic in the bloodstream, insulin floods the bloodstream to remove any glucose you don’t burn immediately and stores it as either glycogen (in the liver and muscle tissues) or in the fat cells as triglyceride (the storage form of fat). When insulin removes glucose from your bloodstream and transports it into storage, you experience the familiar sugar crash and a craving for quick-energy carbohydrates. You have plenty of fat energy locked away in storage, but a high-insulin-producing diet prevents you from being able to access it. Instead, you become reliant on your next snack or meal for energy, and you exist in a state of carbohydrate dependency.

You need a little bit of fat—even the saturated kind—to maintain normal anabolic hormone levels. When you eat pure carbs and no fat, this can also aggravate blood sugar problems in those who are susceptible, develop into metabolic syndrome, and eventually lead to type 2 diabetes and cardiovascular disease. Eating healthy fat (and fiber) slows digestion, which helps control blood sugar and insulin more effectively. This makes fats especially important for people who are carb intolerant. Most surprising to many, eating nothing but nonfat, high-carb meals can sabotage your fat-loss goals by increasing hunger. After eating carbs without fiber or fat, your blood sugar peaks and quickly crashes, leaving you with that shaky, empty I-have-to-eat-now-or-I’m-going-to-pass-out feeling. It’s more than an emotional craving for a specific food; it’s physical hunger and it’s hard to resist. Cutting out all fat is not the answer. You need to eat fat.

Autoimmune Disease—the “Leak” in Your Gut Autoimmune diseases are a disaster and there are no good medicines available (steroids work, but the treatment is worse than the disease). They’ve been around for centuries, but there’s been a clear uptick in the last fifty years. Why? Two hypotheses have been proffered to explain it: the barrier hypothesis (our skin or lungs are letting in antigens) and the hygiene hypothesis (we don’t eat dirt and are too hygienic). But in fact, in the gut, they’re the same thing; because the gut is the dirtiest place in the world—one hundred trillion bacteria to have to fend off at all times—you don’t need an intestine, you need a fortress. We’ve known for a while that leaky gut is akin to chinks in the walls of that fortress. Antigens, like enemy soldiers, escape through those chinks into the bloodstream, where T cells and antibodies react against them. But in a case of mistaken identity, these immune cells then accidentally identify parts of your body as foreign invaders and generate an immune response to kill them off, a process termed molecular mimicry. Then there are two new twists. First, it appears that one autoimmune disease, called ankylosing spondylitis, produces antibodies to a gut bacterium called Klebsiella pneumoniae. Conversely, a different autoimmune disease called rheumatoid arthritis produces antibodies to a second gut bacterium called Proteus mirabilis. Now, this might not seem that earth-shattering, but recent work has shown that the refined carbohydrates in processed food feed those two bacteria in particular, and that carbohydrate restriction improves both of these diseases. Indeed, a low-sugar, high-fiber Mediterranean diet has been shown to be efficacious at prevention and treatment of rheumatoid arthritis. Furthermore, introduction of fiber to the diet appears to improve asthma (frequently an autoimmune disease), likely by improving gut function and reducing inflammation.

Weight stigma can contribute to health problems in a number of ways. Perhaps the most obvious one is that it’s stressful to be stigmatized for your size, and stress takes a physical toll on your body. The scientific term for this toll is allostatic load, meaning the cumulative effect of chronic stressors on multiple systems in the body: the cardiovascular system, the sympathetic and parasympathetic nervous systems, and metabolism. Because it looks at the entire body rather than isolated parts, allostatic load has been shown to be a more robust predictor of chronic-disease risk than other markers. And the research is clear that weight stigma has seriously detrimental whole-body effects. One study that followed close to 1,000 participants for ten years found that those who reported experiencing significant weight stigma over that period were twice as likely to have a high allostatic load as those who didn’t—regardless of actual BMI.5 In other words, weight stigma is an independent risk factor for physiological stress.

Everything in Nature ran according to its own nature; the running of grass was in its growing, the running of rivers their flowing, granite bubbled up, cooled, compressed and crumbled, birds lived, flew, sang and died, everything did what it needed to do, each simultaneously running its own race, each by living according to its own nature together, never leaving any other part of the universe behind. The world’s Holy things raced constantly together, not to win anything over the next, but to keep the entire surging diverse motion of the living world from grinding to a halt, which is why there is no end to that race; no finish line. That would be oblivion to all. For the Indigenous Souls of all people who can still remember how to be real cultures, life is a race to be elegantly run, not a race to be competitively won. It cannot be won; it is the gift of the world’s diverse beautiful motion that must be maintained. Because human life has been give the gift of our elegant motion, whether we limp, roll, crawl, stroll, or fly, it is an obligation to engender that elegance of motion in our daily lives in service of maintaining life by moving and living as beautifully as we can. All else has, to me, the familiar taste of that domineering warlike harshness that daily tries to cover its tracks in order to camouflage the deep ruts of some old, sick, grinding, ungainly need to flee away from the elegance of our original Indigenous human souls. Our attempt to avariciously conquer or win a place where there are no problems, whether it be Heaven or a “New Democracy,” never mind if it is spiritually ugly and immorally “won” and taken from someone who is already there, has made a citifying world of people who, unconscious of it, have become our own ogreish problem to ourselves, our future, and the world. This is a problem that we cannot continue to attempt to competitively outrun by more and more effectively designed technological approaches to speed away from the past, for the specter of our own earth-wasting reality runs grinning competitively right alongside us. By developing even more effective and entertaining methods of escape that only burn up the earth, the air, animals, plants, and the deeper substance of what it should mean to be human, by competing to get ahead, we have created a brakeless competition that has outrun our innate beauty and marked out a very definite and imminent “finish” line. Living in and on a sphere, we cannot really outrun ourselves anyway. Therefore, I say, the entire devastating and hideous state of the world and its constant wounding and wrecking of the wild, beautiful, natural, viable and small, only to keep alive an untenable cultural proceedance is truly a spiritual sickness, one that will not be cured by the efficient use of the same thinking that maintains the sickness. Nor can this overly expensive, highly funded illness be symptomatically kept at bay any longer by yet more political, environmental, or social programs. We must as individuals and communities take the time necessary to learn how to indigenously remember what a sane, original existence for a viable people might look like. Though there are marvellous things and amazing people doing them, both seen and unseen, these do not resemble in any way the general trend of what is going on now. To begin remembering our Indigenous belonging on the Earth back to life we must metabolize as individuals the grief of recognition of our lost directions, digest it into a valuable spiritual compost that allows us to learn to stay put without outrunning our strange past, and get small, unarmed, brave, and beautiful. By trying to feed the Holy in Nature the fruit of beauty from the tree of memory of our Indigenous Souls, grown in the composted failures of our past need to conquer, watered by the tears of cultural grief, we might become ancestors worth descending from and possibly grow a place of hope for a time beyond our own.

They basically suggest that specificity allows for a handful of neurons, whose activity is too faint to be measurable, to hypothetically explain lifetimes of complex and coherent experiences. Resuscitation specialist Dr. Sam Parnia’s candid rebuttal of this suggestion seems to frame it best: ‘When you die, there’s no blood flow going into your brain. If it goes below a certain level, you can’t have electric activity. It takes a lot of imagination to think there’s somehow a hidden area of your brain that comes into action when everything else isn’t working.’38 But even if we grant that there is hidden neural activity somewhere, the materialist position immediately raises the question of why we are born with such large brains if only a handful of neurons were sufficient to confabulate unfathomable dreams. After all, as a species, we pay a high price for our large brains in terms of metabolism and in terms of having to be born basically premature, since a more developed head cannot pass through a woman’s birth canal. Moreover, under ordinary conditions, it has been scientifically demonstrated that we generate measurable neocortical activity even when we dream of the mere clenching of a hand!39 It is, thus, incoherent to postulate that undetectable neural firings – the extreme of specificity – are sufficient to explain complex experiences.

Of all the metals there is none more essential to life than iron. It is the accumulation of iron in the center of a star which triggers a supernova explosion and the subsequent scattering of the vital atoms of life throughout the cosmos. It was the drawing by gravity of iron atoms to the center of the primeval earth that generated the heat which caused the initial chemical differentiation of the earth, the outgassing of the early atmosphere, and ultimately the formation of the hydrosphere. It is molten iron in the center of the earth which, acting like a gigantic dynamo, generates the earth's magnetic field, which in turn creates the Van Allen radiation belts that shield the earth's surface from destructive high-energypenetrating cosmic radiation and preserve the crucial ozone layer from cosmic ray destruction… Without the iron atom, there would be no carbon-based life in the cosmos; no supernovae, no heating of the primitive earth, no atmosphere or hydrosphere. There would be no protective magnetic field, no Van Allen radiation belts, no ozone layer, no metal to make hemoglobin [in human blood], no metal to tame the reactivity of oxygen, and no oxidative metabolism. The intriguing and intimate relationship between life and iron, between the red color of blood and the dying of some distant star, not only indicates the relevance of metals to biology but also the biocentricity of the cosmos… This account clearly indicates the importance of the iron atom. The fact that particular attention is drawn to iron in the Qur'an also emphasises the importance of the element.

The human capacity to respond with great variety is testament to the core principles that have guided our exploration thus far: the entropic two-step and evolution by natural selection. The entropic two-step explains how orderly clumps can form in a world that is becoming ever more disordered, and how certain of these clumps, stars, can remain stable over billions of years as they produce a steady output of heat and light. Evolution explains how, in a favorable environment such as a planet bathed by a star’s steady warmth, collections of particles can coalesce in patterns that facilitate complex behaviors, from replication and repair, to energy extraction and metabolic processing, to locomotion and growth. Collections that acquire the further capacities to think and learn, to communicate and cooperate, to imagine and predict, are better equipped to survive and hence to produce similar collections with similar capacities. Evolution thus selects for these abilities and, generation upon generation, refines them. In time, some collections conclude that their cognitive powers are so remarkable that they transcend physical law. Some of the most thoughtful of these collections are then bewildered by the conflict between the freedom of will they experience and the unyielding control of physical law they recognize. But the fact is there is no conflict because there is no transcending of physical law. There can’t be. Instead, the collections of particles need to reassess their powers, focusing not on the laws that govern particles themselves but on the high-level, thoroughly complex, and extraordinarily rich behaviors each collection of particles—each individual—can exhibit and experience. And with that reorientation, the particle collections can tell an illuminating story of wondrous behaviors and experiences, suffused with wills that feel free and speak as though they have autonomous control, and yet are fully governed by the laws of physics.

In order to avoid the deafening of conspecifics, some bats employ a jamming avoidance response, rapidly shifting frequencies or flying silent when foraging near conspecifics. Because jamming is a problem facing any active emission sensory system, it is perhaps not surprising (though no less amazing) that similar jamming avoidance responses are deployed by weakly electric fish. The speed of sound is so fast in water that it makes it difficult for echolocating whales to exploit similar Doppler effects. However, the fact that acoustic emissions propagate much farther and faster in the water medium means that there is less attenuation of ultrasound in water, and thus that echolocation can be used for broader-scale 'visual' sweeping of the undersea environment. These constraints and trade-offs must be resolved by all acoustic ISMs, on Earth and beyond. There are equally universal anatomical and metabolic constraints on the evolvability of echolocation that explain why it is 'harder' to evolve than vision. First, as noted earlier, a powerful sound-production capacity, such as the lungs of tetrapods, is required to produce high-frequency emissions capable of supporting high-resolution acoustic imaging. Second, the costs of echolocation are high, which may limit acoustic imaging to organisms with high-metabolisms, such as mammals and birds. The metabolic rates of bats during echolocation, for instance, are up to five times greater than they are at rest. These costs have been offset in bats through the evolutionarily ingenious coupling of sound emission to wing-beat cycle, which functions as a single unit of biomechanical and metabolic efficiency. Sound emission is coupled with the upstroke phase of the wing-beat cycle, coinciding with contraction of abdominal muscles and pressure on the diaphragm. This significantly reduces the price of high-intensity pulse emission, making it nearly costless. It is also why, as any careful crepuscular observer may have noticed, bats spend hardly any time gliding (which is otherwise a more efficient means of flight).

DRY SAUNA Numerous cultures use sweat lodges, steam baths, or saunas for cleansing and purification. Many health clubs and big apartment buildings have saunas and steam baths, and more and more people are building saunas in their own homes. Low-to-moderate-temperature saunas are one of the most important ways to detoxify from pesticide exposure. Head-to-toe perspiration through the skin, the largest organ of elimination, releases stored toxins and opens the pores. Fat that is close to the skin is heated, mobilized, and broken down, releasing toxins and breaking up cellulite. The heat increases metabolism, burns off calories, and gives the heart and circulation a workout. This is a boon if you don’t have the energy to exercise. It is well known in medicine that a fever is the body’s way of burning off an infection and stimulating the immune system. Fever therapy and sauna therapy are employed at alternative medicine healing centers to do just that. The controlled temperature in a sauna is excellent for relaxing muscular aches and pains and relieving sinus congestion. The only way I made it through my medical internship was by having regular saunas to reduce the daily stress. FAR-INFRARED (FIR) SAUNAS FIR saunas are inexpensive, convenient, and highly effective. Detox expert Dr. Sherry Rogers says that FIR is a proven and efficacious way of eliminating stored environmental toxins, and she thinks everyone should use one. There are one-person Sauna Domes that you lie under or more elaborate sauna boxes that seat several people. The far infrared provides a heat that increases the body temperature but the surrounding air is not overly heated. One advantage of the dome is that your head remains outside, which most people find more comfortable and less confining. Sweating begins within minutes of entering the dome and can be continued for thirty to sixty minutes. Besides the hundreds of toxins that can be removed through simple sweating, the heat of saunas creates a mild shock to the body, which researchers feel acts as a stimulus for the body’s cells to become more efficient. The outward signs are the production of sweat to help decrease the body temperature, but there is much more going on. Further research on sauna therapy is destined to make it an important medical therapy.

Over time, the active verbs of the Shema-recite, walk, talk, lie down, rise, bind, fix, write, all in the service of love-become too much for us to imagine, let alone perform. Our search for superpowers has created many of the most pressing problems of our time. The defining mental activity of our time is scrolling Our capacities of attention, memory, and concentration are diminishing; to compensate, we toggle back and forth between infinite feeds of news, posts, images, episodes - taking shallow hits of trivia, humor, and outrage to make up for the depths of learning, joy, and genuine lament that now feel beyond our reach. The defining illness of our time is metabolic syndrome, the chronic combination of high weight, high cholesterol, high blood pressure, and high blood sugar that is the hallmark of an inactive life. Our strength is atrophying and our waistline expanding, and to compensate, we turn to the superpowers of the supermarket with the aisles of salt and fat convincing our bodies’ reward systems, one bite at a time, that we have never been better in our life. The defining emotional challenge of our time is anxiety, the fear of what might be instead of the courageous pursuit of what could be. Once, we lived with allness of heart, with a boldness of quest that was too in love with the good to call off the pursuit when we encountered risk. Now we live as voyeurs, pursuing shadowy vestiges of what we desire from behind the one-way mirror of a screen, invulnerable but alone. And, of course, the soul is the plane of human ex- istence that our technological age neglects most of all. Jesus asked whether it was worth gaining the whole world at the cost of losing one's soul. But in the era of superpowers, we have not only lost a great deal of our souls-we have lost much of the world as well. We are rarely overwhelmed by wind or rain or snow. We rarely see, let alone name, the stars. We have lost the sense that we are both at home and on a pilgrimage in the vast, mysterious cosmos, anchored in a rich reality beyond ourselves. We have lost our souls without even gaining the world. So it is no wonder that the defining condition of our time is a sense of loneliness and alienation. For if human flourishing requires us to love with all our hearts, souls, minds, and strength, what happens When nothing in our lives develops those capacities? With what, exactly, will we love?

Myoclonic seizures are brief shock-like jerks of a muscle or group of muscles. They occur in a variety of epilepsy syndromes that have different characteristics. Epilepsy can experience myoclonus in hiccups or in a sudden jerk that may wake you up as you’re just falling asleep. Myoclonus refers to a quick, involuntary muscle jerk. Myoclonus may occur because of a nervous system (neurological) disorder, such as epilepsy, a metabolic condition, or a reaction to a medication. Myoclonic epilepsy are caused by abnormal electrical activity in the brain, which triggers the myoclonic muscle movements. The cause of myoclonus is corrected if possible. For example, drugs that can cause myoclonus are stopped. A high or low blood sugar level is corrected, and kidney failure is treated with hemodialysis. If the cause cannot be corrected, certain ant seizure drugs (such as valproate and levetiracetam) or clonazepam (a mild sedative) may lessen symptoms. Asian Neuro Centre is one of the largest and most experienced practices in Indore where the best & experienced neurologist is skilled in dozens of specialties, working to ensure quality care and successful recovery.

If mutual mate choice is indeed influencing mental characteristics, this may help to explain variability in intelligence, even though intelligence is highly heritable (e.g., Miller, 1997). Recall, that in order to be reliable fitness indicators, traits must demonstrate high individual differences; traits may be highly heritable if they “tap into genetic variation in fitness,” because fitness itself seems to be a heritable characteristic (Miller, 2000b). Although brain size correlates with intelligence (Rushton & Ankney, 1996), creating a large brain is costly for the organism in terms of metabolic energy necessary to support the brain, time necessary to produce it, as well as the physical difficulty and health complications of squeezing through a small pelvic opening during delivery. Intelligence is also correlated with other fitness indicators, in particular, body symmetry (Furlow, Armijo-Prewitt, Gangestad, & Thornhill, 1997). Prokosch, Yeo, and Miller (2005) have found evidence that general intelligence (g) reflects developmental stability. Furthermore, the finding that humans assortively mate with others of similar intelligence, which should increase variability in intelligence in the general population, lends weight to the idea that indicators of g are used as indicators of fitness (Rushton 1989; Rushton & Bonns, 2005).

Obesity is a hormonal dysregulation of fat mass. The body maintains a body set weight, much like a thermostat in a house. When the body set weight is set too high, obesity results. If our current weight is below our body set weight, our body, by stimulating hunger and/or decreasing metabolism, will try to gain weight to reach that body set weight. Thus, excessive eating and slowed metabolism are the result rather than the cause of obesity.

There is value in exercise, though, and I think that the most important type of exercise, especially in terms of bang for your buck, is going to be really high-intensity, heavy strength training. Strength training aids everything from glucose disposal and metabolic health to mitochondrial density and orthopedic stability. That last one might not mean much when you’re a 30-something young buck, but when you’re in your 70s, that’s the difference between a broken hip and a walk in the park.

I’ve seen patients work themselves into NAFLD by drinking too many “healthy” fruit smoothies, for the same reason: they are taking in too much fructose, too quickly. Thus, the almost infinite availability of liquid fructose in our already high-calorie modern diet sets us up for metabolic failure if we’re not careful (and especially if we are not physically active).

probably also had high levels of uric acid, which as we saw in the previous chapter is often found in the company of high blood pressure and other signs of metabolic dysfunction.

The transition from the fed state to the fasted state occurs in several stages:3 1.Feeding: During meals, insulin levels are raised. This allows glucose uptake by tissues such as the muscle or brain for direct use as energy. Excess glucose is stored as glycogen in the liver. 2.The post-absorptive phase (six to twenty-four hours after fasting starts): Insulin levels begin to fall. The breakdown of glycogen releases glucose for energy. Glycogen stores last for roughly twenty-four hours. 3.Gluconeogenesis (twenty-four hours to two days): The liver manufactures new glucose from amino acids and glycerol. In non-diabetic persons, glucose levels fall but stay within the normal range. 4.Ketosis (one to three days after fasting starts): The storage form of fat, triglycerides, is broken into the glycerol backbone and three fatty acid chains. Glycerol is used for gluconeogenesis. Fatty acids may be used directly for energy by many tissues in the body, but not the brain. Ketone bodies, capable of crossing the blood-brain barrier, are produced from fatty acids for use by the brain. Ketones can supply up to 75 percent of the energy used by the brain.4 The two major types of ketones produced are beta hydroxybutyrate and acetoacetate, which can increase more than seventy-fold during fasting.5 5.Protein conservation phase (after five days): High levels of growth hormone maintain muscle mass and lean tissues. The energy for maintenance of basal metabolism is almost entirely met by the use of free fatty acids and ketones. Increased norepinephrine (adrenalin) levels prevent the decrease in metabolic rate.

Intelligent vs. unintelligent High strung vs. placid & laid back Extraverted vs. introverted Low psychic metabolism (low energy) vs. high psychic metabolism (high energy) Extraordinary talent (or accomplishment) vs. ordinary abilities & accomplishments Ambitious vs. content with status quo Attractive vs. unattractive Cultured vs. barbarian Spiritual vs. unspiritual (or different styles of spirituality) Philosophical vs. frivolous Risk taker vs. obsessed with safety Commitment to vigorous personal growth vs. content with the status quo Visionary vs. lives in the moment Scrupulously honest vs. morally flexible Wealth-acquisition mindset vs. poverty mindset Neat and organized vs. slovenly and disorganized Logical thinker vs. emotional, reactive thinker Couch potato vs. physically active Regular exercise regimen vs. none Involved in service outreaches vs. pursues only personal pleasuring Argumentative Andy vs. non-confrontational Carla Back packer Bert vs. five-star-hotel-connoisseur Connie Frugal Freddy vs. shop-‘til-you-drop Shelley

A Japanese study published in the Annals of Nutrition and Metabolism in 2015 reported that high cholesterol does not lead to heart disease and protects against many illnesses, including cancer. This study found an inverse relationship between all-cause mortality and cholesterol levels.

The fat loss power of kettlebells is explained by the extremely high metabolic cost of throwing a weight around combined with the fat burning effect of the growth hormone stimulated by such exercise. The author of Manly Weight Loss, top strength coach Charles Poliquin, explains:

Then there are two new twists. First, it appears that one autoimmune disease, called ankylosing spondylitis, produces antibodies to a gut bacterium called Klebsiella pneumoniae. Conversely, a different autoimmune disease called rheumatoid arthritis produces antibodies to a second gut bacterium called Proteus mirabilis. Now, this might not seem that earth-shattering, but recent work has shown that the refined carbohydrates in processed food feed those two bacteria in particular, and that carbohydrate restriction improves both of these diseases. Indeed, a low-sugar, high-fiber Mediterranean diet has been shown to be efficacious at prevention and treatment of rheumatoid arthritis. Furthermore, introduction of fiber to the diet appears to improve asthma (frequently an autoimmune disease), likely by improving gut function and reducing inflammation.

On the other end of the spectrum are high-glycemic carbs, possessing a high dose of sugar, likely refined sugar at that, and little to no fiber. These foods, sometimes labeled “bad” carbs, trigger spikes in blood sugar levels, making it hard for your body’s insulin to metabolize so much quick sugar at once. Over time, this exhausts your pancreas, causing insulin resistance. Insulin resistance inflames your body and its systems, posing a risk factor for metabolic disorders, diabetes, and heart disease. It can also harm estrogen production, the last thing anyone needs. Great examples of high-glycemic carbs aren’t just the obvious ones like packaged treats, sugary cookies, commercial pastries, and candies.

As unpredictable as the content of the LSD reaction is its intensity; the individual responses to the same dosage level vary considerably. My experience indicates that the degree of sensitivity or resistance to LSD depends on complicated psychological factors rather than on variables of a constitutional, biological, or metabolic nature. Subjects who in everyday life have the need to maintain full self-control and have difficulties in relaxing and “letting go” can sometimes resist relatively high dosages of LSD (300 to 500 micrograms) and show no detectable changes. Occasionally, a person can resist a considerable dose of LSD if he has set this as a personal task for himself for any reason. He may decide to do this to defy the therapist and compete with him, to demonstrate his “strength” to himself and to others, to endure more than his fellow patients, or for many other reasons. Usually, however, more relevant unconscious motives can be found underlying such superficial rationalizations. Another cause for a high resistance to the effect of the drug may be insufficient preparation, instruction, and reassurance of the subject, a lack of his full agreement and cooperation, or absence of basic trust in the therapeutic relationship. In this case, the LSD reaction sometimes does not take its full course until the motives of resistance are analyzed and understood. Occasional sudden sobering, which can occur at any period of the session and on any dosage level, can be understood as a sudden mobilization of defenses against the emergence of unpleasant traumatic material. Among psychiatric patients, severe obsessive-compulsive neurotics are particularly resistant to the effect of LSD. It has been a common observation in my research that such patients can resist dosages of more than 500 micrograms of LSD and show only slight signs of physical or psychological distress. In extreme cases, it can take several dozen high-dose LSD sessions before the psychological resistances of these individuals are reduced to the point that they start having episodes of regression to childhood and become aware of the unconscious material that has to be worked through.

THE EIGHT GUIDING PRINCIPLES The eight guiding principles reveal how to detect and work with the energetic imbalances in the body. In fact, the principles consist of four polar opposites, which are as follows. INTERNAL/EXTERNAL Internal/external determines the location but not the cause of the problem. Internal organs are often affected by an emotional issue, and less frequently by an unknown cause or an external factor. External disorders are either caused by an outside-of-the-body pathogen that attacks suddenly or an acute or chronic invasion in the channel. External symptoms might involve the hair, muscles, and peripheral nerves and blood vessels, while internal systems involve the organs, deep vessels and nerves, brain, and spinal cord. HOT/COLD Hot/cold indicates the nature of the imbalance and the overall energy of the patient. Full heat or hot is excess heat in the interior. Excess heat is too much yang. Empty heat is deficient yin in the interior (usually caused by Kidney yin deficiency.) Full cold is excess cold in the interior. Excess cold comes from too much yin. Empty or deficient cold is a deficiency of yang. Hot and cold can coexist within the system. Cold symptoms might involve chills and pale skin, while hot symptoms could involve a raging fever and high metabolism. FULL/EMPTY Full/empty describes excess versus deficiency. It indicates the presence of a pathogen as well as the condition of the bodily chi. Full describes the presence of an internal or external pathogen or stagnated chi, blood, or food. Empty indicates no pathogen but weak chi, yin, yang, or blood. Mixed portrays the presence of a pathogen and weak chi, blood, yin, or yang. Full or excess symptoms often accompany a condition that is acute or sudden-onset, while empty or deficiency syndromes are more chronic and slow-moving.

THE EIGHT GUIDING PRINCIPLES The eight guiding principles reveal how to detect and work with the energetic imbalances in the body. In fact, the principles consist of four polar opposites, which are as follows. INTERNAL/EXTERNAL Internal/external determines the location but not the cause of the problem. Internal organs are often affected by an emotional issue, and less frequently by an unknown cause or an external factor. External disorders are either caused by an outside-of-the-body pathogen that attacks suddenly or an acute or chronic invasion in the channel. External symptoms might involve the hair, muscles, and peripheral nerves and blood vessels, while internal systems involve the organs, deep vessels and nerves, brain, and spinal cord. HOT/COLD Hot/cold indicates the nature of the imbalance and the overall energy of the patient. Full heat or hot is excess heat in the interior. Excess heat is too much yang. Empty heat is deficient yin in the interior (usually caused by Kidney yin deficiency.) Full cold is excess cold in the interior. Excess cold comes from too much yin. Empty or deficient cold is a deficiency of yang. Hot and cold can coexist within the system. Cold symptoms might involve chills and pale skin, while hot symptoms could involve a raging fever and high metabolism. FULL/EMPTY Full/empty describes excess versus deficiency. It indicates the presence of a pathogen as well as the condition of the bodily chi. Full describes the presence of an internal or external pathogen or stagnated chi, blood, or food. Empty indicates no pathogen but weak chi, yin, yang, or blood. Mixed portrays the presence of a pathogen and weak chi, blood, yin, or yang. Full or excess symptoms often accompany a condition that is acute or sudden-onset, while empty or deficiency syndromes are more chronic and slow-moving. CHI, BLOOD, AND FLUIDS: THE THREE UNIFYING INGREDIENTS THE FOUR LEVELS, six stages, and eight principles all revolve around the same three bodily ingredients: chi, blood, and non-blood bodily fluids. While a serious illness involves all three, many problems revolve around issues with one or another. These are the main conditions involving blood, chi, or the fluids. CHI CONDITIONS Deficient chi: Not enough chi to perform the necessary functions. Sinking or collapsed chi: The Spleen chi cannot perform its supportive functions. Stagnated chi: The chi flow is impaired. If congested or stuck in an organ, there can be pain, sluggishness, or stiffness. Rebellious chi: The chi flows in the wrong direction.

Plant proteins are not only free of animal fat and cholesterol; they are also free of two problems caused by animal proteins. First, animal protein is linked to osteoporosis, apparently because it causes the kidneys to lose calcium in the urine. If you were to check urine samples from people following meaty diets—especially high-protein Atkins-style diets—you would find that they lose calcium rapidly.3 Sodium does the same thing, as we’ll see below. Second, animal protein is also linked to gradual loss of kidney function. Harvard researchers studied a group of women who had already lost some kidney function, as many people do, due to high blood pressure, diabetes, urinary infections, or other factors. As the years went by, the researchers found that those women who tended to get their protein from animal products were much more likely to experience continued loss of kidney function.4 Protein from plants did not have this effect. So if you get your protein from beans, grains, vegetables, and other foods from plant sources, your kidneys will breathe a sigh of relief.

first order of business is to reduce the burden of apoB particles, primarily LDLs but also VLDLs, which can be dangerous in their own right. And do so dramatically, not marginally or incrementally. We want it as low as possible, sooner rather than later. We must also pay attention to other markers of risk, notably those associated with metabolic health, such as insulin, visceral fat, and homocysteine, an amino acid that in high concentrations[*7] is strongly associated with increased risk of heart attack, stroke, and dementia.

for good health, avoid the scary and intense blood-sugar roller coaster (peaks followed by crashes) and stick to the cute and gentle blood-sugar caterpillar ride (slow and steady ups and downs). Having a high glucose response to your meals is a risk factor for obesity, diabetes, cardiovascular disease, and other metabolic disorders, and it’s also a predictor of higher overall mortality.

The up-and-down-day approach is highly recommended: If you have insulin resistance. The down days (particularly if you choose the full-fast option) are great for reducing your insulin levels. If you are dealing with metabolic slowdown. The up days come with a metabolic-boosting benefit that your body may need. If you have plateaued while using an eating-window approach. If you find that your body adapts to the regularity of a daily eating window, the up-and-down-day pattern is great for shaking things up and getting weight loss moving in the right direction.

And yes, genetics appears to play a role in about half the total risk for being alcohol addicted. But there’s no evidence that Native Americans have any versions of genes that metabolize alcohol any differently from white people in America, nor is there a simple single genetic factor that might render someone an alcoholic. There is plenty of evidence for brutal social and cultural experiences for many Native Americans, and generations of oppression, resulting in underemployment, poverty, and low socioeconomic status, all of which are risk factors for alcoholism. Yet, the notion that the high rates of alcoholism in Native Americans—almost twice as high as in white European immigrant Americans—are somehow genetic remains an oft-repeated idea.

most people collect ungainly fat around the middle. This “central” or “visceral” fat is unique: Unlike fat in other body areas, it provokes inflammatory phenomena, distorts insulin responses, and issues abnormal metabolic signals to the rest of the body. Visceral fat is responsible for effects as varied as cancer, knee arthritis, and infertility. In the unwitting wheat-bellied male, visceral fat also produces estrogen and other hormonal distortions that create “man breasts.” In susceptible females, the same inflammatory fat causes abnormally high testosterone levels, male-like facial hair, and infertility.

a recent study fried some falafel in canola oil at high temperature, and then mixed the spent oil into rat feed; those rats that ate spent canola oil had a higher incidence of colon tumors and gut inflammation than those who ate canola oil cooked at lower temperatures. The lower the oil’s smoking point, the easier it is to turn it into a trans-fat. Extra virgin olive oil has the lowest smoking point of all the fats, at 160°C (320°F).

On the other hand, intact fiber—found in Real Food—has many benefits, and not just short-chain fatty acids (SCFAs). In the processed food industry, the germ of the grain (the nucleic acids, flavonoids, polyphenols) is removed along with the fiber because they can go rancid (see Chapter 19). Protecting the liver means maintaining the fiber and keeping the germ intact as well. Two simple precepts—protect the liver, feed the gut. Real Food (low-sugar, high-fiber) does both. Processed food (high-sugar, low-fiber) does neither. Processed food is the primary suspect in our current health and healthcare debacle, because it doesn’t improve our eight subcellular pathologies, our three nutrient-sensing enzymes, and our two physiologic precepts.

Keep testing your blood and urine every 2 months and adjust your doses accordingly. If the tests reveal your kidneys are working well and your calcium metabolism is within the reference range, the next step will be to look at your PTH levels: ·         If PTH levels are below the lowest reference value, you’ll need to reduce the vitamin D you are taking. ·         If PTH levels are at the lowest value, but still within the reference range, you’ll need to maintain the same dose of vitamin D you have been taking. ·         If PTH is within the reference range, but not yet at the lowest value, it’s time to increase vitamin D supplementation. This is, by far, the most common scenario. You may increase doses by 10,000 IU or by 20,000 IU, or more, depending on how far away from our goal you are.

Red: Most yang, warm, and stimulating. Produces heat. Stimulates vital energy and circulation of the blood. Stimulates sensory nervous systems and energizes the five basic senses. Stimulates the healing of wounds without pus. Used in treatment of chronic infections. Too much red leads to anger and hyperactivity. Orange: Gentle yang, tonifies. Stimulates appetite, relieves cramps and spasms, increases blood pressure, induces vomiting, relieves gas, builds bones. When used with blue, regulates the endocrine system. Stimulates joy, optimism, and enthusiasm. Yellow: Yang, and the brightest of all colors. Strengthens motor nervous system and metabolism, and aids conditions of the glandular, lymphatic, and digestive systems. Stimulates intellectual functions; boosts cheerfulness and confidence. Green: Neutral yin. Slightly cooling. Treats conditions of the lungs, eyes, diabetes, musculoskeletal and inflammatory joint problems, and ulcers. Is antibacterial and aids in detoxification. Calms, soothes, and balances. Blue: Yin or cool. Relaxes body and mind, reduces fever, congestion, itching, irritation, and pain. Treats high blood pressure, burns, inflammations with pus and diseases involving heat. Contracts tissues and muscles. Calms and tranquilizes when used on the pituitary and pineal acupoints. Helpful for insomnia, phobias, and endocrine imbalances. Not indicated for depression as it is a melancholy color. Violet: Most yin color. Aids the spleen, reduces irritability, and balances the right brain. When combined with yellow, increases lymph production, controls hunger, and balances the nervous system. Acts on the unconscious.35 Complementary Colors The complementary color pairs are: red-green, orange-blue, and yellow-violet. Together, these colors balance yin and yang. For example, red might stimulate the blood and improve circulation while green calms conditions creating stress. Blue might assuage pain while orange lifts fear or depression causing tension. Yellow will strengthen the nervous system while violet calms it with a meditative state.

Here’s a research study that shows just how differently teens’ brains function: In a Magnetic Resonance Imaging (MRI) study, teenagers and adults were presented pictures of people who looked scared or anxious. The adults recognized the fear in the faces but placed the experiences in a larger context, so it didn’t affect them personally. The opposite was true of the teens: they did not report that the faces were fearful, but they became emotionally involved and reported more fear and anxiety themselves. In teens, the parts of the brain that process gut reactions and primitive emotions — the amygdala and insula — were active. But in adults, the frontal lobes were activated as well. In other words, the teenagers’ brains responded emotionally. They felt upset but their brains did not identify the source of those feelings. The adults’ brains added reason to that response. Remember this when your teen gets upset “for no reason.” He may not be able to say why he’s feeling that way, but his feelings are still valid. He doesn’t have the connections between his rational brain and his emotional brain that would allow him to explain it. Logic doesn’t help because the teen’s brain cannot follow abstract logic. They are doing the best they can with the brain connections they have. This is especially true if your teen is a boy. As we see later, girls have more connections between their emotional and executive centers. Astrocytes: Functional and structural support Astrocytes are another class of glial cells. They are star-shaped, hence their name, and provide structural and functional support for the neuron. Astrocytes form the matrix that keeps neurons in place. But they are more than inert bricks in a passive wall. Rather, they function more like the mother who ensures her children have brushed their teeth, are wearing their coats in winter, and are eating good meals. An astrocyte is pictured in Figure 3.3. Astrocytes sit between blood vessels and neurons and breakdown glucose from the capillaries into lactic acid, which the mitochondria of the neurons use for energy. As a wise mother, they do not break down all of the glycogen they receive from the blood, but create a reserve for times when the metabolic need of neurons are especially high.

Chia seeds may be small, but their weight loss benefits pack a powerful punch. With high levels of fiber and protein, these tiny seeds can help you feel fuller for longer, curb cravings, and promote healthy digestion. Plus, their omega-3 fatty acids can help boost metabolism and burn fat. Incorporate chia seeds into your diet and watch those extra pounds melt away!

So, back to The Hand and the celestials. They weren’t born? How do they feel like they do? Neverra and Logan are married. The joy and laughter I saw in Logan’s memories were true love.” “The celestials are sentient beings created by my father and the other gods. Their primary purpose is to serve. As you saw, they can love true. Their high metabolism requires that they eat a lot. They are highly sexual and have the same passion for fighting. They are brave, quick to adapt, and very good at war, making them the perfect killing machines. It made them invaluable during battle.

Because ibis don’t eat silverside and pickles sandwiches,’ Dad says. ‘You’re only giving it the sandwich chunks because you want to feel good about yourself. That’s a selfish mindset. You start feeding that bird from this window every day then it’ll start dropping by every afternoon like we’re fuckin’ Big Rooster and it brings its friends and then none of those birds get the strength and exercise they usually get from finding food the hard way so you drastically alter their metabolisms, not to mention cause widespread civil war among the Bracken Ridge ibis community as they battle to be the first to chomp into your silverside and pickles treat. Moreover, you suddenly get an unnaturally high level of birds in one place, which affects the ecological balance of the whole Bracken Ridge area. I know I don’t always practise this but, basically, you know, the whole point of life is doing things that are right over things that are easy. Because you want to feel good about yourself, suddenly the ibis are spending less time in the wetlands on a tree and more time on the ground in a fuckin’ car park rubbing shoulders with the pigeons, and then we start getting inter-species contact and weaker immune systems in the birds and higher stress hormones and from that little petri dish of dynamite springs salmonella

Then in March 1993, everything changed. My one-year-old son, Charlie, had his first seizure. There’s absolutely nothing funny about being the parent of a child with uncontrolled epilepsy. Nothing. After a year of daily seizures, drugs, and a brain surgery, I learned that the cure for Charlie’s epilepsy, the ketogenic diet—a high fat, no sugar, limited protein diet—had been hiding in plain sight for, by then, over seventy years. And despite the diet’s being well documented in medical texts, none of the half-dozen pediatric neurologists we had taken Charlie to see had mentioned a word about it. I found out on my own at a medical library. It was life altering—not just for Charlie and my family, but for tens of thousands like us. Turns out there are powerful forces at work within our health care system that don’t necessarily prioritize good health. For decades, physicians have barely been taught diet therapy or even nutrition in medical school. The pharmaceutical, medical device, and sugar industries make hundreds of billions every year on anti-epileptic drugs and processed foods—but not a nickel if we change what we eat. The cardiology community and American Heart Association demonize fat based on flawed science. Hospitals profit from tests and procedures, but again no money from diet therapy. There is a world epilepsy population of over sixty million people. Most of those people begin having their seizures as children, and only a minuscule percentage ever find out about ketogenic diet therapies. When I realized that 99 percent of what had happened to Charlie and my family was unnecessary, and that there were millions of families worldwide in the same situation, I needed to try to do something. Nancy and I began the Charlie Foundation (charliefoundation.org) in 1994 in order to facilitate research and get the word directly to those who would benefit. Among the high points were countless articles, a couple appearances of Charlie’s story on Dateline NBC, and a movie I produced and directed about another family whose child’s epilepsy had been cured by the ketogenic diet starring Meryl Streep titled First Do No Harm (1997). Today, of course, the diet permeates social media. When we started, there was one hospital in the world offering ketogenic diet therapy. Today, there are 250. Equally important, word about the efficacy of the ketogenic diet for epilepsy spread within the scientific community. In 1995, we hosted the first of many scientific global symposia focused on the diet. As research into its mechanisms and applications has spiked, incredibly the professional communities have found the same metabolic pathway that is triggered by the ketogenic diet to reduce seizures has also been found to benefit Alzheimer’s disease, ALS, severe psychiatric disorders, traumatic brain injury, and even some cancers. I

Conscious breathing is the easiest form of meditation and the most basic part of yoga, which I highly recommend if you have the inclination to take classes in anything. This type of breathing disconnects eating from our stress-response equipment, a major cause of overeating and bingeing. It also enhances our overall energy by releasing energy in every cell of the body. Breathing is the driving process of metabolism.

Your metabolism is as high as it will ever be; enjoy it and don’t be afraid to try new foods, but don’t neglect fresh fruits and vegetables in season.

As shifters, our metabolism ran high the best of times. His body would need more calories to get through this adjustment period, plus the sheer size of Thatch suggested he’d need more anyway.

According to Dr. Mark Hyman, “the triglyceride-to-HDL ratio is the best way to check for insulin resistance other than the insulin response test. According to a paper published in Circulation, the most powerful test to predict your risk of a heart attack is the ratio of your triglycerides to HDL. If the ratio is high, your risk for a heart attack increases sixteen-fold—or 1,600 percent! This is because triglycerides go up and HDL (or ‘good cholesterol’) goes down with diabesity.

But the medicalization of chronic disease in the past fifty years has been an abject failure. Today, we’ve siloed diseases and have a treatment for everything: High cholesterol? See a cardiologist for a statin. High fasting glucose? See an endocrinologist for metformin. ADHD? See a neurologist for Adderall. Depressed? See a psychiatrist for a selective serotonin reuptake inhibitor (SSRI). Can’t sleep? See a sleep specialist for Ambien. Pain? See a pain specialist for an opioid. PCOS? See an OB-GYN for clomiphene. Erectile dysfunction? See a urologist for Viagra. Overweight? See an obesity specialist for Wegovy. Sinus infections? See an ENT for an antibiotic or surgery. But what nobody talks about—what I think many doctors don’t even realize—is that the rates of all these conditions are going up at the exact time we are spending trillions of dollars to “treat them.

Keep It Simple With food, we covered three simple rules that get you quite far: don’t eat added sugar, don’t eat industrially processed vegetable and seed oils, and don’t eat highly processed grains. With fitness, I also suggest three simple rules. Walk at least 7,000 steps per day and space these steps out throughout the day. Work up to 10,000 per day. Get your heart rate above 60 percent of your maximum for at least 150 minutes a week. (That’s 30 minutes, five days a week.) Lift heavy things multiple times per week in a way that hits every major muscle group.

GOOD ENERGY BIOMARKERS AND MOVEMENT When you’re striving to be part of the 6.8 percent of metabolically healthy Americans, regular movement will help you get there. Research shows that exercise improves all five of the following basic biomarkers of metabolism: Glucose Levels Above 100 mg/dL: Twelve-week exercise programs of either high-intensity running (40 minutes per week) or low-intensity running (150 minutes per week) both brought participants’ blood sugar from the prediabetic range (100 mg/dL or greater) to the nondiabetic range (<100 mg/dL). HDL Cholesterol Less Than 40 mg/dL: A 2019 review of the literature showed that exercise increased HDL cholesterol, “with exercise volume, rather than intensity, having a greater influence.” Meanwhile, “raising HDL levels pharmacologically has not shown convincing clinical benefits.” Triglycerides Above 150 mg/dL: Numerous studies have demonstrated that physical activity effectively lowers triglyceride levels. In a 2019 study, an eight-week moderate aerobic exercise program significantly reduced triglyceride levels in participants. Furthermore, even a single session of intense aerobic exercise has been found to decrease triglyceride levels the following day. This positive effect could be due to the increased activity of hepatic lipase in the liver, an enzyme that facilitates the absorption of triglyceride from the bloodstream. Blood Pressure of 130/85 mmHg or Higher: Research has shown the effects of exercise among populations with high blood pressure were similar to the effects of commonly used medications. A Waistline of More Than 35 Inches for Women and 40 Inches for Men: Not surprisingly, regular exercise can help decrease obesity by increasing energy expenditure and promoting weight loss. Research shows a clear inverse relationship between the amount of movement people do each week and the size of their waistline: more movement, smaller waist circumference. What’s more, lower activity (fewer than 5,100 steps per day) yields a 2.5 times higher risk of central obesity than higher activity (more than 8,985 steps per day).

From a nutrition standpoint, the observation that a high-salt diet can cause obesity may seem surprising. Salt has no calories. However, in our study, the reason a high-salt diet caused obesity was not the salt itself, but rather the high salt concentration in the blood that activated the polyol system. That system converted much of the glucose the mice ate to fructose, which was then metabolized, activating the survival switch.

HDL is often referred to as “good” because it helps remove cholesterol from the blood vessels and carries it back to the liver for processing and elimination from the body. This process of reverse cholesterol transport can help prevent the buildup of plaque in the arteries and reduce the risk of heart disease and stroke. Therefore, high levels of HDL in the bloodstream are considered beneficial for cardiovascular health. Meanwhile, LDL (low-density lipoprotein) is often referred to as “bad” cholesterol because it can deposit cholesterol in the walls of the arteries, leading to the formation of plaque. This process, known as atherosclerosis, can narrow the arteries and increase the risk of heart disease and stroke.

The two main ingredients of Beyond Burger are pea protein and canola oil. Canola oil is high in omega-6 fats, making Beyond Burger more inflammatory than grass-fed beef. Additional ingredients include natural flavors (a misnomer, as natural flavors can be highly processed and contain chemical additives) and methylcellulose, a main ingredient in laxatives manufactured by heating wood in acidic solutions to extract and purify cellulose.

In nature, metabolic syndrome is an insurance plan. For humans today, metabolic syndrome is a disorder, a harbinger presaging the development of diabetes, high blood pressure, and heart disease. What was meant to aid survival is now causing disease. Metabolic syndrome represents both nature’s success and its failure.