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HH Dalai Lama: Some forms of meditation are very difficult. One of my close friends was a very good meditator who attempted to cultivate single-pointedness of mind. He had the experience of spending a few years in a Chinese prison, and he told me that the meditation was actually harder than being a prisoner. The point is that he had to be constantly aware and attentive without losing his attention even for a moment. A constant vigilance was required. One factor that needs to be taken into account is the intensity and quality of the meditator’s motivation. In the traditional Buddhist context, meditators are highly motivated individuals who have a deep appreciation of the framework of the Buddhist path and an understanding of its causes and effects: If I do this, this will happen. They understand the nature of the path and its culmination. There is a deep recognition that the fulfillment of one’s aspiration for happiness really lies in the transformation of one’s undisciplined state to a more disciplined state of mind. These individuals take into account all of this context, so when they engage in meditation, they have a tremendous sense of dedication, joy, a very strong motivation, and sustained enthusiasm. But if you just tell a child, with no context at all, to start meditating, there will be no incentive, no inspiration. Robert, you made the comment that in small doses, stress can actually raise dopamine levels, which we assume corresponds in the rat to a heightened sense of well-being or pleasure. I wonder whether there might be an analogue in meditation, specifically in the training of single-pointed attention, or samadhi, which is not uniquely Buddhist. As one trains incrementally in developing attention, a quality arises that is described as suppleness or malleability of the body and mind, and is often conjoined with a sense of well-being, perhaps even bliss. It happens very strongly when one achieves a high state of samadhi, but even incrementally along the path, there are many surges of this type of malleability together with a kind of bliss. This may be an interesting area of research, to see from the neurophysiological perspective what some of the unexpected events are that come out of such attentional training.
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Jon Kabat-Zinn (The Mind's Own Physician: A Scientific Dialogue with the Dalai Lama on the Healing Power of Meditation)