Grey Cells Quotes

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You should employ your little grey cells
Agatha Christie (The Murder of Roger Ackroyd (Hercule Poirot, #4))
He pulls up outside my duplex. I belatedly realize he’s not asked me where I live - yet he knows. But then he sent the books, of course he knows where I live. What able, cell-phone-tracking, helicopter owning, stalker wouldn’t.
E.L. James (Fifty Shades of Grey (Fifty Shades, #1))
If the little grey cells are not exercised, they grow the rust.
Agatha Christie (The A.B.C. Murders (Hercule Poirot, #13))
The little grey cells, my friend, the little grey cells! They told me.
Agatha Christie (The Murder on the Links (Hercule Poirot, #2))
There, weeping, a tsarevna lies locked in a cell. And Master Grey Wolf serves her very well. There, in her mortar, sweeping beneath the skies, the demon Baba Yaga flies. There Tsar Koschei, he wastes away, poring over his pale gold.
Catherynne M. Valente (Deathless)
... what would Poirot do? Poirot wouldn't flap around in a panic. He'd stay calm and use his little grey cells and recall some tiny, vital detail which would be the clue to everything.
Sophie Kinsella (I've Got Your Number)
A malformation of the grey cells may coincide quite easily with the face of a Madonna.
Agatha Christie (The Murder on the Links (Hercule Poirot, #2))
We all have the little grey cells. And so few of us know how to use them.
Agatha Christie (The Adventure of the Italian Nobleman: a Hercule Poirot Short Story (Hercule Poirot, #SS-17))
It is the brain, the little grey cells” — he topped his forehead — “on which one must rely. The senses mislead.
Agatha Christie (The Early Cases of Hercule Poirot)
He talked a lot about the little grey cells of the brain, and of their functions. His own, he says, are of the first quality.' 'He would say so,' I remarked bitterly. 'Modesty is certainly not his middle name.
Agatha Christie (The Murder of Roger Ackroyd (Hercule Poirot, #4))
Use your little grey cells mon ami" (Hercule Poirot in 'The Mysterious Affair At Styles')
Agatha Christie
Was that a personal call, Cammie?” he asked with a shrewd glance. I had a brief moment of panic before composing myself. “Yes. It was my gynecologist. He wanted to discuss my latest pap smear. Do you want to know how the cells on my cervix are doing?
R.S. Grey (The Design (A Heart Novel Series))
Little did they know I wasn’t above backing over nasty reporters. Spoiler: the rest of this story takes place from a jail cell.
R.S. Grey (Scoring Wilder)
Then, there on the screen I saw Montgomery Clift and Elizabeth Taylor. An American Tragedy, a film I'd seen at least twice, not that it was all that great, but still it was very good, especially the final scene, which was unreeling at this particular moment: Clift and Taylor standing together, separated by the bars of a prison cell, a death cell, for Clift is only hours away from execution. Clift, already a poetic ghost inside his grey death-clothes, and Taylor, nineteen and ravishing, sublimely fresh as lilac after rain.
Truman Capote (Answered Prayers: The Unfinished Novel)
But me, I am old-fashioned. I use the old methods. I work only with the little grey cells.
Agatha Christie (The Murder of Roger Ackroyd (Hercule Poirot, #4))
...And the good heart, it is worth in the end all the little grey cells. Yes, yes, I who speak to you am in danger of forgetting that sometimes.
Agatha Christie (Hercule Poirot: The Complete Short Stories)
The word “idiot” comes from a Greek root meaning private person. Idiocy is the female defect: intent on their private lives, women follow their fate through a darkness deep as that cast by malformed cells in the brain. It is no worse than the male defect, which is lunacy: men are so obsessed by public affairs that they see the world as by moonlight, which shows the outlines of every object but not the details indicative of their nature.
Rebecca West (Black Lamb and Grey Falcon)
Her question made me remember that the word ‘idiot’ comes from a Greek root meaning private person. Idiocy is the female defect: intent on their private lives, women follow their fate through a darkness deep as that cast by malformed cells in the brain. It is no worse than the male defect, which is lunacy: they are so obsessed by public affairs that they see the world as by moonlight, which shows the outlines of every object but not the details indicative of their nature.
Rebecca West (Black Lamb and Grey Falcon)
on my cell phone, telling me about a housewarming party, but
R.S. Grey (The Foxe & the Hound)
His only shortcoming was a lamentable lack of grey matter, which he took in stride, cheerfully proclaiming that while he might not have two brain cells to rub together, he was dim enough that he didn't notice their lack.
Arden Powell (The Bachelor's Valet (Flos Magicae #2))
The mountain pine beetle is a tiny creature that chews through a lodgepole’s bark, gouges out a hollow in the wood and lays its eggs. The larvae hatch hungry and feed on the cambium layer, a tree’s most vital part, the annual layer of cells that makes up a growth ring. To prevent drowning in the tree’s sap, the beetle larvae can eject a choking fungus that not only halts the life-giving flow of sap, but stains the wood a grey-blue color.
Annie Proulx (Bird Cloud: A Memoir of Place)
Think, Carter. Use the “little grey cells”, as Agatha Christie’s Poirot says in the stories. All the great detectives spent time reflecting on the case. Remember Sherlock Holmes playing his violin far into the night.’ ‘And injecting himself with cocaine?’ interjected Steph. ‘You won’t be doing that, will you, sir?’ she asked cheekily. ‘No,’ replied Oldroyd. ‘The similarities between myself and Conan Doyle’s creation are few, apart from our brilliantly perceptive minds.
J.R. Ellis (The Body in the Dales (Yorkshire Murder Mysteries, #1))
Fire, fire! The branches crackle and the night wind of late autumn blows the flame of the bonfire back and forth. The compound is dark; I am alone at the bonfire, and I can bring it still some more carpenters' shavings. The compound here is a privileged one, so privileged that it is almost as if I were out in freedom -- this is an island of paradise; this is the Marfino "sharashka" -- a scientific institute staffed with prisoners -- in its most privileged period. No one is overseeing me, calling me to a cell, chasing me away from the bonfire, and even then it is chilly in the penetrating wind. But she -- who has already been standing in the wind for hours, her arms straight down, her head drooping, weeping, then growing numb and still. And then again she begs piteously "Citizen Chief! Please forgive me! I won't do it again." The wind carries her moan to me, just as if she were moaning next to my ear. The citizen chief at the gatehouse fires up his stove and does not answer. This was the gatehouse of the camp next door to us, from which workers came into our compound to lay water pipes and to repair the old ramshackle seminary building. Across from me, beyond the artfully intertwined, many-stranded barbed-wire barricade and two steps away from the gatehouse, beneath a bright lantern, stood the punished girl, head hanging, the wind tugging at her grey work skirt, her feet growing numb from the cold, a thin scarf over her head. It had been warm during the day, when they had been digging a ditch on our territory. And another girl, slipping down into a ravine, had crawled her way to the Vladykino Highway and escaped. The guard had bungled. And Moscow city buses ran right along the highway. When they caught on, it was too late to catch her. They raised the alarm. A mean, dark major arrived and shouted that if they failed to catch the girl, the entire camp would be deprived of visits and parcels for whole month, because of her escape. And the women brigadiers went into a rage, and they were all shouting, one of them in particular, who kept viciously rolling her eyes: "Oh, I hope they catch her, the bitch! I hope they take scissors and -- clip, clip, clip -- take off all her hair in front of the line-up!" But the girl who was now standing outside the gatehouse in the cold had sighed and said instead: "At least she can have a good time out in freedom for all of us!" The jailer had overheard what she said, and now she was being punished; everyone else had been taken off to the camp, but she had been set outside there to stand "at attention" in front of the gatehouse. This had been at 6 PM, and it was now 11 PM. She tried to shift from one foot to another, but the guard stuck out his head and shouted: "Stand at attention, whore, or else it will be worse for you!" And now she was not moving, only weeping: "Forgive me, Citizen Chief! Let me into the camp, I won't do it any more!" But even in the camp no one was about to say to her: "All right, idiot! Come on it!" The reason they were keeping her out there so long was that the next day was Sunday, and she would not be needed for work. Such a straw-blond, naive, uneducated slip of a girl! She had been imprisoned for some spool of thread. What a dangerous thought you expressed there, little sister! They want to teach you a lesson for the rest of your life! Fire, fire! We fought the war -- and we looked into the bonfires to see what kind of victory it would be. The wind wafted a glowing husk from the bonfire. To that flame and to you, girl, I promise: the whole wide world will read about you.
Aleksandr Solzhenitsyn (The Gulag Archipelago 1918–1956 (Abridged))
There’s a workaround for encroaching phone stupidity. The first thing I did when I got to my place in Austin – an apartment rented for three days over the internet – was connect the thing to wifi. Just like that, my secondary brain got all its little grey cells back. The next few days were all about scurrying from wifi field to field, trying to keep the thing on life support. It’s a workaround. We live in a workaround culture. You have to jiggle the key in the ignition just right to start the car. You have to hold the TV remote at a certain angle. You know how it goes.
Warren Ellis (CUNNING PLANS: Talks By Warren Ellis)
Poem: Roses And Rue (To L. L.) Could we dig up this long-buried treasure, Were it worth the pleasure, We never could learn love's song, We are parted too long. Could the passionate past that is fled Call back its dead, Could we live it all over again, Were it worth the pain! I remember we used to meet By an ivied seat, And you warbled each pretty word With the air of a bird; And your voice had a quaver in it, Just like a linnet, And shook, as the blackbird's throat With its last big note; And your eyes, they were green and grey Like an April day, But lit into amethyst When I stooped and kissed; And your mouth, it would never smile For a long, long while, Then it rippled all over with laughter Five minutes after. You were always afraid of a shower, Just like a flower: I remember you started and ran When the rain began. I remember I never could catch you, For no one could match you, You had wonderful, luminous, fleet, Little wings to your feet. I remember your hair - did I tie it? For it always ran riot - Like a tangled sunbeam of gold: These things are old. I remember so well the room, And the lilac bloom That beat at the dripping pane In the warm June rain; And the colour of your gown, It was amber-brown, And two yellow satin bows From your shoulders rose. And the handkerchief of French lace Which you held to your face - Had a small tear left a stain? Or was it the rain? On your hand as it waved adieu There were veins of blue; In your voice as it said good-bye Was a petulant cry, 'You have only wasted your life.' (Ah, that was the knife!) When I rushed through the garden gate It was all too late. Could we live it over again, Were it worth the pain, Could the passionate past that is fled Call back its dead! Well, if my heart must break, Dear love, for your sake, It will break in music, I know, Poets' hearts break so. But strange that I was not told That the brain can hold In a tiny ivory cell God's heaven and hell.
Oscar Wilde (Selected Poems)
and endless inconvenience. But have I not heard you say often that to solve a case a man has only to lie back in his chair and think? Do that. Interview the passengers on the train, view the body, examine what clues there are and then—well, I have faith in you! I am assured that it is no idle boast of yours. Lie back and think—use (as I have heard you say so often) the little grey cells of the mind—and you will know!” He leaned forward, looking affectionately at his friend. “Your faith touches me, my friend,” said Poirot emotionally. “As you say, this cannot be a difficult case. I myself, last night—but we will not speak of that now. In truth, this problem intrigues me. I was reflecting, not half an hour ago, that many hours of boredom lay ahead whilst we are stuck here. And now—a problem lies ready to my hand.” “You accept then?” said M. Bouc eagerly. “C’est entendu. You place the matter in my hands.” “Good—we are all at your service.” “To begin with, I should like a plan of the Istanbul-Calais coach, with a note of the people who occupied the several compartments, and I should also like to see their passports and their tickets.” “Michel will get you those.” The Wagon Lit conductor left the compartment. “What other passengers are there on the train?” asked Poirot. “In this coach Dr. Constantine and I
Agatha Christie (Murder on the Orient Express (Hercule Poirot, #10))
Come on, I’ll take you home,” he murmurs. “I need to tell Kate.” Holy Moses, I’m in his arms again. “My brother can tell her.” “What?” “My brother Elliot is talking to Miss Kavanagh.” “Oh?” I don’t understand. “He was with me when you phoned.” “In Seattle?” I’m confused. “No, I’m staying at the Heathman.” Still? Why? “How did you find me?” “I tracked your cell phone Anastasia.
E.L. James (Fifty Shades of Grey (Fifty Shades, #1))
For us there is only one season, the season of sorrow. The very sun and moon seem taken from us. Outside, the day may be blue and gold, but the light that creeps down through the thickly-muffled glass of the small iron-barred window beneath which one sits is grey and niggard. It is always twilight in one’s cell, as it is always twilight in one’s heart. And in the sphere of thought, no less than in the sphere of time, motion is no more.
Oscar Wilde (De Profundis)
And that date, too, is far off?' 'Far off; when it comes, think your end in this world is at hand!' 'How and what is the end? Look east, west, south and north.' 'In the north, where you never yet trod, towards the point whence your instincts have warned you, there a spectre will seize you. 'Tis Death! I see a ship - it is haunted - 'tis chased - it sails on. Baffled navies sail after that ship. It enters the regions of ice. It passes a sky red with meteors. Two moons stand on high, over ice-reefs. I see the ship locked between white defiles - they are ice-rocks. I see the dead strew the decks - stark and livid, green mold on their limbs. All are dead, but one man - it is you! But years, though so slowly they come, have then scathed you. There is the coming of age on your brow, and the will is relaxed in the cells of the brain. Still that will, though enfeebled, exceeds all that man knew before you, through the will you live on, gnawed with famine; and nature no longer obeys you in that death-spreading region; the sky is a sky of iron, and the air has iron clamps, and the ice-rocks wedge in the ship. Hark how it cracks and groans. Ice will imbed it as amber imbeds a straw. And a man has gone forth, living yet, from the ship and its dead; and he has clambered up the spikes of an iceberg, and the two moons gaze down on his form. That man is yourself; and terror is on you - terror; and terror has swallowed your will. And I see swarming up the steep ice-rock, grey grisly things. The bears of the north have scented their quarry - they come near you and nearer, shambling and rolling their bulk, and in that day every moment shall seem to you longer than the centuries through which you have passed. And heed this - after life, moments continued make the bliss or the hell of eternity.' 'Hush,' said the whisper; 'but the day, you assure me, is far off - very far! I go back to the almond and rose of Damascus! - sleep!' ("The House And The Brain
Edward Bulwer-Lytton (Reign of Terror Volume 2: Great Victorian Horror Stories)
As there is no appearance of daylight, what is to be done during the night? It occurred to me that I would arise and examine, by my lamp, the wails of my cell. They are covered with writings, with drawings, fantastic figures, and names which mix with and efface each other. It would appear that each prisoner had wished to leave behind him some trace here at least. Pencil, chalk, charcoal, — black, white, grey letters; sometimes deep carvings upon the stone. If my mind were at ease, I could take an interest in this strange book, which  is developed page by page, to my eyes, on each stone of this dungeon. I should like to recompose these fragments of thought; to trace a character for each name; to give sense and life to these mutilated inscriptions, — these dismembered phrases.
Victor Hugo (Complete Works of Victor Hugo)
I lingered at the gates; I lingered on the lawn; I paced backwards and forwards on the pavement; the shutters of the glass door were closed; I could not see into the interior; and both my eyes and spirit seemed drawn from the gloomy house—from the grey hollow filled with rayless cells, as it appeared to me—to that sky expanded before me,—a blue sea absolved from taint of cloud; the moon ascending it in solemn march; her orb seeming to look up as she left the hill-tops, from behind which she had come, far and farther below her, and aspired to the zenith, midnight dark in its fathomless depth and measureless distance; and for those trembling stars that followed her course; they made my heart tremble, my veins glow when I viewed them. Little things recall us to earth; the clock struck in the hall; that sufficed; I turned from moon and stars, opened a side-door, and went in.
Charlotte Brontë (Jane Eyre)
He was walking down a narrow street in Beirut, Lebanon, the air thick with the smell of Arabic coffee and grilled chicken. It was midday, and he was sweating badly beneath his flannel shirt. The so-called South Lebanon conflict, the Israeli occupation, which had begun in 1982 and would last until 2000, was in its fifth year. The small white Fiat came screeching around the corner with four masked men inside. His cover was that of an aid worker from Chicago and he wasn’t strapped. But now he wished he had a weapon, if only to have the option of ending it before they took him. He knew what that would mean. The torture first, followed by the years of solitary. Then his corpse would be lifted from the trunk of a car and thrown into a drainage ditch. By the time it was found, the insects would’ve had a feast and his mother would have nightmares, because the authorities would not allow her to see his face when they flew his body home. He didn’t run, because the only place to run was back the way he’d come, and a second vehicle had already stopped halfway through a three-point turn, all but blocking off the street. They exited the Fiat fast. He was fit and trained, but he knew they’d only make it worse for him in the close confines of the car if he fought them. There was a time for that and a time for raising your hands, he’d learned. He took an instep hard in the groin, and a cosh over the back of his head as he doubled over. He blacked out then. The makeshift cell Hezbollah had kept him in in Lebanon was a bare concrete room, three metres square, without windows or artificial light. The door was wooden, reinforced with iron strips. When they first dragged him there, he lay in the filth that other men had made. They left him naked, his wrists and ankles chained. He was gagged with rag and tape. They had broken his nose and split his lips. Each day they fed him on half-rancid scraps like he’d seen people toss to skinny dogs. He drank only tepid water. Occasionally, he heard the muted sound of children laughing, and smelt a faint waft of jasmine. And then he could not say for certain how long he had been there; a month, maybe two. But his muscles had wasted and he ached in every joint. After they had said their morning prayers, they liked to hang him upside down and beat the soles of his feet with sand-filled lengths of rubber hose. His chest was burned with foul-smelling cigarettes. When he was stubborn, they lay him bound in a narrow structure shaped like a grow tunnel in a dusty courtyard. The fierce sun blazed upon the corrugated iron for hours, and he would pass out with the heat. When he woke up, he had blisters on his skin, and was riddled with sand fly and red ant bites. The duo were good at what they did. He guessed the one with the grey beard had honed his skills on Jewish conscripts over many years, the younger one on his own hapless people, perhaps. They looked to him like father and son. They took him to the edge of consciousness before easing off and bringing him back with buckets of fetid water. Then they rubbed jagged salt into the fresh wounds to make him moan with pain. They asked the same question over and over until it sounded like a perverse mantra. “Who is The Mandarin? His name? Who is The Mandarin?” He took to trying to remember what he looked like, the architecture of his own face beneath the scruffy beard that now covered it, and found himself flinching at the slightest sound. They had peeled back his defences with a shrewdness and deliberation that had both surprised and terrified him. By the time they freed him, he was a different man.  
Gary Haynes (State of Honour)
they catch us, we’re going right back into the cell.” Roark went silent, and then dragged a chair out from the table. “Sit,” he ordered gently, moving away from it and taking the one on the opposite side. I sat down after a fraction of a second, and then looked at him expectantly. “It’s good that you’re thinking of us as a ‘we,’” he said, “because at this point we are, and we’re all in it together.” “Yes, but to what end? What purpose? What is your ultimate goal here?” I knew I came off as a bit angry, but the truth was I was frustrated. My patience was almost gone, and I was scared and tired—a dangerous combination that always led to emotional outbursts. For his part, Roark didn’t seem to mind my anger. In fact, his face looked almost vacant, lost in thought, and a bit sad. I leaned forward, concerned, but then his eyes flicked over to me and he began to speak. “Her name was Selka,” he said, and then paused. I bit back a sigh and leaned back. Why did everyone want to do this kind of storytelling with me, during which I had to participate and ask questions to coax the story forward? Why couldn’t anyone just be direct? “She was my wife,” he continued, just as I was about to ask the question, and I quickly closed my mouth, my frustration fading somewhat as I remembered Grey’s words. “She wasn’t
Bella Forrest (The Girl Who Dared to Think (The Girl Who Dared, #1))
So, even if you have most of the grey cells in the meeting, be clever enough to conceal your cleverness, if only to diffuse the insecurity of the A and his other Cs.
Richard Hytner (Consiglieri - Leading from the Shadows: Why Coming Top Is Sometimes Second Best)
If a ship landed in my yard and LGMs stepped out, I’d push past their literature and try to find the cable that dropped the saucer on my roses. Lack of a cable or any significant burning to the flowers, I’d then grab a hammer and start knocking about in the ship till I was convinced that nothing said “Intel Inside.” Then when I discovered a “Flux Capacitor” type thing I would finally stop and say, “Hey, cool gadget!” Assuming the universal benevolence of the LGMs, I’d yank it out and demand from the nearest "Grey” (they are the tall nice ones), “where the hell did this come from?” Greys don’t talk, they communicate via telepathy, so I’d ignore the voice inside my head. Then stepping outside the saucer and sitting in a lawn chair, I’d throw pebbles at the aliens till I was sure they were solid. Then I’d look down at the “Flux Capacitor” and make sure it hadn’t morphed into my bird feeder. Finally, with proof in my hand and aliens sitting on my deck (they’d be offered beers, though I’ve heard that they absorb energy like a plant) I’d grab my cell phone and tell my doctor that I’m having a serious manic episode with full-blown visual hallucinations.
Peter K. Bertine
The corridor has twenty doors on the left-hand side and eighteen doors on the right-hand side. Also it has a door at either end. One door is painted red, and it leads to the classroom–so Melanie thinks of that as the classroom end of the corridor. The door at the other end is bare grey steel and it’s really, really thick. Where it leads to is a bit harder to say. Once when Melanie was being taken back to her cell, the door was off its hinges, with some men working on it, and she could see how it had all these bolts and sticking-out bits around the edges of it, so when it’s closed it would be really hard to open. Past the door, there was a long flight of concrete steps going up and up. She wasn’t supposed to see any of that stuff, and Sergeant said, “Little bitch has got way too many eyes on her” as he shoved her chair into her cell and slammed the door shut. But she saw, and she remembers. She
M.R. Carey (The Girl With All the Gifts)
And the good heart, it is in the end worth all the little grey cells. Yes, yes. I who speak to you am in danger of forgetting that sometimes.
Agatha Christie (AGATHA CHRISTIE Collection : The Mysterious Affair at Styles, Poirot Investigates, The Murder on the Links, The Secret Adversary, The Man in the Brown Suit)
In contrast to most of the examples given in this chapter, it is occasionally recorded that even solitary confinement imposed by enemies can be the trigger for psychological experiences of lasting value. Anthony Grey, who experienced solitary confinement in China, and Arthur Koestler, who was similarly imprisoned in Spain, discussed their experiences together on television. The transcript of their discussion appears in Koestl’s collection of essays, Kaleidoscope. Both men were grateful that they did not have to share a cell with another prisoner. Both felt that solitude enhanced their appreciation of, and sympathy with, their fellow men. Both had intense experiences of feeling that some kind of higher order of reality existed with which solitude put them in touch. Both felt that trying to put this experience into words tended to trivialize it, because words could not really express it. Although neither man subscribed to any orthodox religious belief, both agreed that they had felt the abstract existence of something which was indefinable or which could only be expressed in symbols. Anthony Grey thought that his experience had given him a new awareness and appreciation of normal life. Koestler concurred, but added that he had also become more aware of horrors lurking under the surface. Koestler also refers to a feeling of inner freedom, of being alone and confronted with ultimate realities instead of with your bank statement. Your bank statement and other trivialities are again a kind of confinement. Not in space but in spiritual space . . . So you have got a dialogue with existence. A dialogue with life, a dialogue with death. Grey comments that this is an area of experience into which most people do not enter. Koesder righdy affirms that most people have occasional confrontations of this kind when they are severely ill or when a parent dies, or when they first fall in love. Then they are transferred from what I call the trivial plane to the tragic or absolute plane. But it only happens a few times. Whereas in the type of experience which we shared, one has one’s nose rubbed into it, for a protracted period.17 So, occasionally, good can come out of evil. Anthony Grey recalled being shown a painting by a Chinese friend in which a beautiful lotus flower is growing out of mud. The human spirit is not indestructible; but a courageous few discover that, when in hell, they are granted a glimpse of heaven.
Anthony Storr (Solitude: A Return to the Self)
The true work, it is done from within. The little grey cells—remember always the little grey cells, mon ami.” -- Hercule Poirot
Agatha Christie (The Murder on the Links (Hercule Poirot, #2))
Mon ami, I want to open your brain flap and tickle your little grey cells.
Et Imperatrix Noctem
Use your little grey cells mon ami” Hercule Poiro
Agatha Christie
What were you looking for over here?” Jim asked again. “I wonder if you can exorcise hands…hmm? Oh, where on the wall was that place I sent you through before. Do you remember?” Jim shook its head. “Why are you looking for that particular spot? It have fond memories for you or something?” “Hardly. You told me that it was easier to tear the fabric of existence in a spot where it had previously been rent. And I know I sent you through it from this room, but I don’t remember where, exactly.” I glanced at the clock on the mantel, leaping to my feet when I saw the time. “Oh my god. Oh my god! Tell me that clock isn’t right!” “That clock isn’t right.” Relief made me sag a bit as I dug through my purse looking for my cell phone. “Thank god. I was worried there for a minute that I’d missed the wedding.” “You have,” Jim said complacently, snuffling around behind the fainting couch. “What? You just told me the clock was wrong!” “Yuh-uh. And who ordered me to tell her that?” “Gah!” I screamed, punching a speed-dial number into the phone. “Talk about your day from hell…Jim, look around and find the weak spot. I’m not going to let something like a deranged Guardian ruin my day.” “Sooo many things I could say to that,” Jim said, shaking its head. “I’ll confine myself to pointing out that even if I found the spot, it wouldn’t do you any good.” “It wouldn’t? Why not?” Inside my head, a dark, sinuous voice whistled a peppy little tune. I ground my teeth. “Don’t tell me—I’d have to use the dark power in order to push us through.” “Yup.” Smirk. “Bloody he—Drake!” “Aisling?” I held the phone away from my ear at the sound of Drake’s roar. “Hi, sweetie. Um. I guess we’re even on the whole jilting-at-the-altar thing, huh?” “Where are you? Where have you been? Why have you not answered my calls?” Drake growled. “Rene and your uncle said you just disappeared on the street. Have you been harmed?” “I’m fine. Jim’s here with me. I’m in…er…oh, hell.” “Abaddon,” Jim corrected.
Katie MacAlister (Holy Smokes (Aisling Grey, #4))
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Arun (ANTARCTICA–THE COMING IMPACT: Preparing for the Next Frontier of Environmental and Scientific Challenges)
…And the good heart, it is in the end worth all the little grey cells. Yes, yes, I who speak to you am in danger of forgetting that sometimes.
Agatha Christie (Hercule Poirot: The Complete Short Stories)
P3 - ten minutes of that movie, or indeed of any movie whose message is similarly dystopian about a post-aging world (Blade Runner), you will see that they set it up by insinuating, with exactly no justification and also no attempt at discussion (which is how they get away with not justifying it), that the defeat of aging will self-evidently bring about some new problem that we will be unable to solve without doing more harm than good. The most common such problem, of course, is overpopulation - and I refer you to literally about 1000 interviews and hundreds of talks I have given on stage and camera over the past 20 years, of which several dozen are online, for why such a concern is misplaced. The reason there are 1000, of course, is that most people WANT to believe that aging is a blessing in disguise - they find it expedient to put aging out of their minds and get on with their miserably short lives, however irrational must be the rationalizations by which they achieve that. Aubrey has been asked on numerous occasions whether humans should use future tech to extend their lifespans. Aubrey opines, "I believe that humans should (and will) use (and, as a prerequisite, develop) future technologies to extend their healthspan, i.e. their healthy lifespan. But before fearing that I have lost my mind, let me stress that that is no more nor less than I have always believed. The reason people call me an “immortalist” and such like is only that I recognize, and am not scared to say, two other things: one, that extended lifespan is a totally certain side-effect of extended healthspan, and two, that the desire (and the legitimacy of the desire) to further extend healthspan will not suddenly cease once we achieve such-and-such a number of years." On what people can do to advance longevity research, my answer to this question has radically changed in the past year. For the previous 20 years, my answer would have been “make a lot of money and give it to the best research”, as it was indisputable that the most important research could go at least 2 or 3x times faster if not funding-limited. But in the past year, with the influx of at least a few $B, much of it non-profit (and much of it coming from tech types who did exactly the above), the calculus has changed: the rate-limiter now is personnel. It’s more or less the case now that money is no longer the main rate-limiter, talent is: we desperately need more young scientists to see longevity as the best career choice. As for how much current cryopreservation technology will advance in the next 10-20 years, and whether it enough for future reanimation? No question about the timeframe for a given amount of progress in any pioneering tech can be answered other than probabilistically. Or, to put it more simply, I don’t know - but I think there's a very good chance that within five years we will have cryo technology that inflicts only very little damage on biological tissue, such that yes, other advances in rejuvenation medicine that will repair the damage that caused the cryonaut to be pronounced dead in the first place will not be overwhelmed by cryopreservation damage, hence reanimation will indeed be possible. As of now, the people who have been cryopreserved(frozen) the best (i.e. w/ vitrification, starting very shortly immediately after cardiac arrest) may, just possibly, be capable of revival by rewarming and repair of damage - but only just possibly. Thus, the priority needs to be to improve the quality of cryopreservation - in terms of the reliability of getting people the best preservation that is technologically possible, which means all manner of things like getting hospitals more comfortable with cryonics practice and getting people to wear alarms that will alert people if they undergo cardiac arrest when alone, but even more importantly in terms of the tech itself, to reduce (greatly) the damage that is done to cells and tissues by the cryopreservation process.
Aubrey de Grey
And his mistake?’ I asked, although I suspected the answer. ‘Mon ami, he overlooked the little grey cells of Hercule Poirot.’ Poirot has his virtues, but modesty is not one of them.
Agatha Christie (The Big Four (Hercule Poirot, #5))
P2 - We are well on the way in a number of areas. Both billionaires and big Pharma are getting increasingly interested and money is starting to pour into research because it is clear we can see the light at the end of the tunnel which to investors equates to return on investment. Numerous factors will drive things forward and interest and awareness is increasing rapidly among both scientists, researchers and the general population as well as wealthy philanthropists. The greatest driving force of all is that the baby boomers are aging and this will place increasing demands on healthcare systems. Keep in mind that the average person costs more in medical expenditure in the last year of their life than all the other years put together. Also, the number of workers is declining in most developed countries which means that we need to keep the existing population working and productive as long as possible. Below are a list which are basically all technologies potentially leading to radical life extension with number 5 highlighted which I assume might well be possible in the second half of the century: 1. Biotechnology - e.g stem cell therapies, enhanced autophagy, pharmaceuticals, immunotherapies, etc 2. Nanotechnology - Methods of repairing the body at a cellular and molecular level such as nanobots. 3. Robotics - This could lead to the replacement of increasing numbers of body parts and tends to go hand in hand with AI and whole brain emulation. It can be argued that this is not life extension and that it is a path toward becoming a Cyborg but I don’t share that view because even today we don’t view a quadriplegic as less human if he has four bionic limbs and this will hold true as our technology progresses. 4. Gene Therapies - These could be classified under the first category but I prefer to look at it separately as it could impact the function of the body in very dramatic ways which would suppress genes that negatively impact us and enhance genes which increase our tendency toward longer and healthier lives. 5. Whole brain emulation and mindscaping - This is in effect mind transfer to a non biological host although it could equally apply to uploading the brain to a new biological brain created via tissue engineering this has the drawback that if the original brain continues to exist the second brain would have a separate existence in other words whilst you are identical at the time of upload increasing divergence over time will be inevitable but it means the consciousness could never die provided it is appropriately backed up. So what is the chance of success with any of these? My answer is that in order for us to fail to achieve radical life extension by the middle of the century requires that all of the above technologies must also fail to progress which simply won't happen and considering the current rate of development which is accelerating exponentially and then factoring in that only one or two of the above are needed to achieve life extension (although the end results would differ greatly) frankly I can’t see how we can fail to make enough progress within 10-20 years to add at least 20 to 30 years to current life expectancy from which point progress will rapidly accelerate due to increased funding turning aging at the very least into a manageable albeit a chronic incurable condition until the turn of the 22nd century. We must also factor in that there is also a possibility that we could find a faster route if a few more technologies like CRISPR were to be developed. Were that to happen things could move forward very rapidly. In the short term I'm confident that we will achieve significant positive results within a year or two in research on mice and that the knowledge acquired will then be transferred to humans within around a decade. According to ADG, a dystopian version of the post-aging world like in the film 'In Time' not plausible in the real world: "If you CAREFULLY watch just the first
Aubrey de Grey
The little grey cells of the brain,” explained the Belgian. “Oh, of course; well, we all use them, I suppose.” “In a greater or lesser degree,” murmured Poirot. “And there are, too, differences in quality. Then there is the psychology of a crime. One must study that.
Agatha Christie (Agatha Christie Premium Collection)
Never, never will the grey cells function unless you stimulate them.
Agatha Christie (Agatha Christie Premium Collection)
Most details are insignificant; one or two are vital. It is the brain, the little grey cells”—he tapped his forehead—“on which one must rely. The senses mislead. One must seek the truth within—not without.
Agatha Christie (Agatha Christie Premium Collection)
If you would use your grey cells, and see the whole case clearly as I do, you too would perceive it, my friend.
Agatha Christie (Agatha Christie Premium Collection)
Mona rushed through the shower and selected her best dress, a slinky black wraparound number that she ordered on a whim, online. She piled her hair into a messy up do and lined her eyes in black liner with grey eye shadow for a smoky effect. Berry lip stick, dangly silver earrings and a spritz of perfume completed the look. Just as she was slipping on a pair of strappy heels, her cell phone buzzed. It was her Aunt Bee calling. “Darling! The BOGO sale is a great success. Alana says you almost brought the Frugalicious server down!” “I did!” “Blackberry ginger jam is a knock out!” “Well, it may have been knocked off too.” “Whatdya mean?” Aunt Bee asked. “Lacey MacInroy got hold of my recipes, and I understand she’s preparing my jam for the As You Slice It gala reception tonight.” “Why that little rat!” Aunt Bee said. “Are you going to the reception?” Mona asked. “No way! Alexander has never honored, not one of the Coupon Clipper’s requests for a sale. Are you going?” Aunt Bee asked. “Yup. On my way now. Wish me luck,” and as Mona hung up, she heard Aunt Bee squeak out, “Luck with what?” Mona admired her reflection in the mirror and declared herself ready for action. Grabbing her car keys and purse, she nearly stumbled, racing down the front steps. Driving into town, she felt a feeling she had not experienced in a long time, bravery. This new-found liberation from caring about what anyone thought about her was freeing. She felt like her old self once more, that girl she used to be the
Diana Orgain (Murder as Sticky as Jam (A Gluten Free Mystery, #1))
A recent study for 13 years of 299 seniors, average age 78, found that those who walked six to nine mile per week had 50% reduced risk of cognitive impairment and dementia, and a greater volume of grey matter brain cells.
Earl Fee (One Hundred Years Young the Natural Way: Body, Mind, and Spirit Training)
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Ben Jr Grey
impressions barrage, Lee could no longer grasp the meaning of Vivian's voice as it went on and on explaining things like "crystal cells," "selenoid cells," "grey matter pyramidal cells," powered somehow by atomic fission, "nerve loops" and "synthesis gates" which were not to be confused with "analysis gates" while they looked exactly the same…. Apart from this at least one half of his mental and physical energy had to be expanded in suppressing nausea and bracing himself against the gyrations which still jerked his feet from under him and made friction disks of his shoulders as his body swayed from side to side. All of a sudden he felt that he was being derailed. There was an opening in the plastics wall of the cylinder; a curved metal shield like the blade of a bulldozer jumped into his path, caught him, slowed down his momentum and delivered him safely at a door marked "Apperception-Center 24." It opened and within its frame there stood an angel neatly dressed in the uniform of a registered nurse. "There," said the angel, "at last. How did you like your little Odyssey through The Brain, Dr. Lee?" Lee pushed a hand through the mane of his hair; it felt moist and much tangled up. "Thanks," he said. "It was quite an experience. I enjoyed it; Ulysses, too, probably enjoyed his trip between Scylla and Charybdis—after it was over! It's Miss Leahy, I presume." The reception room where he
Alexander Blade (The Brain)
The glial cells support every neural fiber, collect these fibers into bundles, and separate these bundles from the surrounding tissues and fluids. They give the nerve fibers the tensile strength and elasticity to stretch where stretching is needed, and they fix the nerve bundles securely to other structures where stability is needed. This surrounding glial tissue also comprises the ground substance for the intercellular metabolic activities attendant to the needs of the neurons, mediating the interchange of nutrition, gases, hormones, and waste products between nerves and capillaries, and carrying the white blood cells, antibodies, and other immune factors which guard the lives of the irreplaceable neurons. Other specialized glial cells—oligodendrocytes and Schwann cells—insulate the long axons with a tough, fatty coating called myelin. This insulation prevents signals from one axon inadvertently “leaking” into adjacent axons, and it also speeds up the passage of a neural impulse considerably. Myelin is whitish in color, giving the so-called “white matter” of the nervous system its name. “White matter” contrasts to “grey matter.” the color of cell bodies and axons that are not coated with myelin sheaths.
Deane Juhan (Job's Body: A Handbook for Bodywork)
Detective Inspector George Elms walked the corridor of Belmarsh Prison with a sense of trepidation. Visiting these places was always a strange experience and not just because he was responsible for condemning his fair share of men to a miserable existence in its grey-walled, ten-by-six-foot cells. The atmosphere was one of pent-up frustration. It hung heavily in the air, mingled with the visible, moving dust and the claustrophobic heat. You could taste it in the air. It got worse the deeper you got, the closer to the Category A prisoners — the ‘lifers.’ These men were in the high-security wing, destined never again to see the sun as free men. Some would hardly see another soul. It was one of these men that George was here to see today.
Charlie Gallagher (Her Last Breath (Langthorne #7))