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And what causes these reactions? Observing at the deepest level of reality, he understood that reaction occurs because of ignorance. We are unaware of the fact that we react, and unaware of the real nature of what we react to. We are ignorant of the im-permanent, impersonal nature of our existence and ignorant that attachment to it brings nothing but suffering. Not knowing our real nature, we react blindly. Not even knowing that we have reacted, we persist in our blind reactions and allow them to intensify. Thus we become imprisoned in the habit of reacting, because of ignorance. This is how the Wheel of Suffering starts turning: If ignorance arises, reaction occurs; if reaction arises, consciousness occurs; if consciousness arises, mind-and-matter occur; if mind-and-matter arise, the six senses occur; if the six senses arise, contact occurs; if contact arises, sensation occurs; if sensation arises, craving and aversion occur; if craving and aversion arise, attachment occurs; if attachment arises, the process of becoming occurs; if the process of becoming arises, birth occurs; if birth arises, decay and death occur, together with sorrow, lamentation, physical and mental suffering, and tribulations. Thus arises this entire mass of suffering.
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William Hart (The Art of Living: Vipassana Meditation as Taught by S. N. Goenka)