Genetic Mutation Quotes

If you ever meet a guy and you fall in love with him, but because of some weird genetic mutation he doesn't seem to return the feeling?... Wear that dress.

Vampires were hardly the monsters we were made out to be in fairy tales and television shows. We were hardly different from humans, but for the genetic mutation, fangs, silvering eyes, and periodic penchant for blood. What? I said hardly different.

Our lack of community is intensely painful. A TV talk show is not community. A couple of hours in a church pew each Sabbath is not community. A multinational corporation is neither a human nor a community, and in the sweatshops, defiled agribusiness fields, genetic mutation labs, ecological dead zones, the inhumanity is showing. Without genuine spiritual community, life becomes a struggle so lonely and grim that even Hillary Clinton has admitted "it takes a village".

Only cells that had been transformed by a virus or a genetic mutation had the potential to become immortal.

If we are artists- hell, whether or not we're artists- it is our job, our responsibility, perhaps even our sacred calling, to take whatever life has handed us and make something new, something that wouldn't have existed if not for the fire, the genetic mutation, the sick baby, the accident.

The gravitational waves of the first detection were generated by a collision of black holes in a galaxy 1.3 billion light-years away, and at a time when Earth was teeming with simple, single-celled organisms. While the ripple moved through space in all directions, Earth would, after another 800 million years, evolve complex life, including flowers and dinosaurs and flying creatures, as well as a branch of vertebrates called mammals. Among the mammals, a sub-branch would evolve frontal lobes and complex thought to accompany them. We call them primates. A single branch of these primates would develop a genetic mutation that allowed speech, and that branch—Homo Sapiens—would invent agriculture and civilization and philosophy and art and science. All in the last ten thousand years. Ultimately, one of its twentieth-century scientists would invent relativity out of his head, and predict the existence of gravitational waves. A century later, technology capable of seeing these waves would finally catch up with the prediction, just days before that gravity wave, which had been traveling for 1.3 billion years, washed over Earth and was detected. Yes, Einstein was a badass.

People of all faiths are responsible to help the weak, the downtrodden, the sick, and the helpless, especially children. And of all the religions in the world, Christians are the only ones that are commanded not to judge, yet we do every day -- gay people, ethnicities different from our own, people in mixed relationships, people with gifts they were born with, power they were born with, genetic mutations they were born with, illnesses of the brain and body. I've got a little girl's mother to save, and, yes, she's a witch. Are you gonna make it possible for me to save her?

All health, beauty, intelligence, and social grace has been teased from a vast butcher’s yard of unbounded carnage, requiring incalculable eons of massacre to draw forth even the subtlest of advantages. This is not only a matter of the bloody grinding mills of selection, either, but also of the innumerable mutational abominations thrown up by the madness of chance, as it pursues its directionless path to some negligible preservable trait, and then — still further — of the unavowable horrors that ‘fitness’ (or sheer survival) itself predominantly entails. We are a minuscule sample of agonized matter, comprising genetic survival monsters, fished from a cosmic ocean of vile mutants, by a pitiless killing machine of infinite appetite. (This is still, perhaps, to put an irresponsibly positive spin on the story, but it should suffice for our purposes here.)

Random mutations much more easily debilitate genes than improve them, and that this is true even of the helpful mutations. Let me emphasize, our experience with malaria’s effects on humans (arguably our most highly studied genetic system) shows that most helpful mutations degrade genes. What’s more, as a group the mutations are incoherent, meaning that they are not adding up to some new system. They are just small changes - mostly degradative - in pre-existing, unrelated genes. The take-home lesson is that this is certainly not the kind of process we would expect to build the astonishingly elegant machinery of the cell. If random mutation plus selective pressure substantially trashes the human genome, why should we think that it would be a constructive force in the long term? There is no reason to think so.

There are lots of things I don't understand - say, the latest debates over whether neutrinos have mass or the way that Fermat's last theorem was (apparently) proven recently. But from 50 years in this game, I have learned two things: (1) I can ask friends who work in these areas to explain it to me at a level that I can understand, and they can do so, without particular difficulty; (2) if I'm interested, I can proceed to learn more so that I will come to understand it. Now Derrida, Lacan, Lyotard, Kristeva, etc. -- even Foucault, whom I knew and liked, and who was somewhat different from the rest -- write things that I also don't understand, but (1) and (2) don't hold: no one who says they do understand can explain it to me and I haven't a clue as to how to proceed to overcome my failures. That leaves one of two possibilities: (a) some new advance in intellectual life has been made, perhaps some sudden genetic mutation, which has created a form of "theory" that is beyond quantum theory, topology, etc., in depth and profundity; or (b) ... I won't spell it out.

Professor Robinson was revealing, not creating, the anger. The fear. And yes, perhaps even the cowardice they kept hidden away. She was like some genetic mutation awakening illnesses that would have normally lain dormant.

Just ten years ago, probably the most prominent atheist of the twentieth century, Antony Flew, concluded that a God must have designed the universe. It was shocking news and made international headlines. Flew came to believe that the extraordinarily complex genetic code in DNA simply could not be accounted for naturalistically. It didn’t make logical sense to him that it had happened merely by chance, via random mutations. It is a remarkable thing that Flew had the humility and intellectual honesty to do a public about-face on all he had stood for and taught for five decades.

At least 15 percent of human females possess a genetic mutation that gives them an extra (fourth) type of color photoreceptor—and this allows them to discriminate between colors that look identical to the majority of us with a mere three types of color photoreceptors.

In microbiology the roles of mutation and selection in evolution are coming to be better understood through the use of bacterial cultures of mutant strains.

Distichiasis. Your eyelashes. A genetic mutation that causes double rows of lashes

If a relative has suffered Ovarian or Breast Cancer, get the genetic screening. It saves lives.

The coming genetic mutation from homo sapiens into homo sanctus will bring wave after wave of enlightened children into the world who will seek only that which is built on natural cosmic laws, not the old systems which were rooted in fear and competition.

cultural change occurs whenever a new meme is introduced and catches on. It might be romanticism or double-entry book-keeping, chaos theory or Pokemon. So where in the world do new memes come from? sometimes they spring full-blown from the brains of artists or scientists, advertising copywriters or teenagers. often a process of mutation is involved in the creation of a new meme, in much the same way that mutations in natural environment can lead to useful new genetic traits.

Did you know that only a tiny minority of viruses cause illness in humans? No one knows how many viruses there are, but their real role, when you get right down to it, is to aid in mutations, to create diversity among life forms. I've read a lot of books on the subject-when you don't need much sleep you have a lot of time to read-and I can tell you that if it weren't for viruses, mankind would never have evolved on this planet. Some viruses get right inside the DNA and change your genetic code, did you know that? And no one can say for sure that HIV, for example, won't one day prove to have been rewriting our genetic code in a way that's essential to our survival as a race. I'm a man who consciously commits murders and scares the hell out of people and makes them reconsider everything, so I'm definitely malignant, yet I think I play a necessary role in this world.

By ignoring our health and consuming unhealthy products, we are unknowingly contributing to the genetic mutation of the human species.

Two million years ago, genetic mutations resulted in the appearance of a new human species called Homo erectus.

After years of disbelief and argument from other scientists, Hayflick’s paper on cell limits became one of the most widely cited in his field. It was an epiphany: scientists had been trying for decades to grow immortal cell lines using normal cells instead of malignant ones, but it had never worked. They thought their technique was the problem, when in fact it was simply that the lifespan of normal cells was preprogrammed. Only cells that had been transformed by a virus or a genetic mutation had the potential to become immortal. Scientists

We hold these truths to be self-evident, that all men are created equal, that they are endowed by their Creator with certain unalienable rights, that among these are life, liberty, and the pursuit of happiness. According to the science of biology, people were not ‘created’. They have evolved. And they certainly did not evolve to be ‘equal’. The idea of equality is inextricably intertwined with the idea of creation. The Americans got the idea of equality from Christianity, which argues that every person has a divinely created soul, and that all souls are equal before God. However, if we do not believe in the Christian myths about God, creation and souls, what does it mean that all people are ‘equal’? Evolution is based on difference, not on equality. Every person carries a somewhat different genetic code, and is exposed from birth to different environmental influences. This leads to the development of different qualities that carry with them different chances of survival. ‘Created equal’ should therefore be translated into ‘evolved differently’. Just as people were never created, neither, according to the science of biology, is there a ‘Creator’ who ‘endows’ them with anything. There is only a blind evolutionary process, devoid of any purpose, leading to the birth of individuals. ‘Endowed by their creator’ should be translated simply into ‘born’. Equally, there are no such things as rights in biology. There are only organs, abilities and characteristics. Birds fly not because they have a right to fly, but because they have wings. And it’s not true that these organs, abilities and characteristics are ‘unalienable’. Many of them undergo constant mutations, and may well be completely lost over time. The ostrich is a bird that lost its ability to fly. So ‘unalienable rights’ should be translated into ‘mutable characteristics’. And what are the characteristics that evolved in humans? ‘Life’, certainly. But ‘liberty’? There is no such thing in biology. Just like equality, rights and limited liability companies, liberty is something that people invented and that exists only in their imagination. From a biological viewpoint, it is meaningless to say that humans in democratic societies are free, whereas humans in dictatorships are unfree. And what about ‘happiness’? So far biological research has failed to come up with a clear definition of happiness or a way to measure it objectively. Most biological studies acknowledge only the existence of pleasure, which is more easily defined and measured. So ‘life, liberty, and the pursuit of happiness’ should be translated into ‘life and the pursuit of pleasure’. So here is that line from the American Declaration of Independence translated into biological terms: We hold these truths to be self-evident, that all men evolved differently, that they are born with certain mutable characteristics, and that among these are life and the pursuit of pleasure.

accidental genetic mutations changed the inner wiring of the brains of Sapiens, enabling them to think in unprecedented ways and to communicate using an altogether new type of language.

Only cells that had been transformed by a virus or a genetic mutation had the potential to become immortal. Scientists knew from studying HeLa that cancer cells could divide indefinitely, and they’d speculated for years about whether cancer was caused by an error in the mechanism that made cells die when they reached their Hayflick Limit. They also knew that there was a string of DNA at the end of each chromosome called a telomere, which shortened a tiny bit each time a cell divided, like time ticking off a clock. As normal cells go through life, their telomeres shorten with each division until they’re almost gone. Then they stop dividing and begin to die. This process correlates with the age of a person: the older we are, the shorter our telomeres, and the fewer times our cells have left to divide before they die. By the early nineties, a scientist at Yale had used HeLa to discover that human cancer cells contain an enzyme called telomerase that rebuilds their telomeres. The presence of telomerase meant cells could keep regenerating their telomeres indefinitely.

As far as we can tell, changes in social patterns, the invention of new technologies and the settlement of alien habitats resulted from genetic mutations and environmental pressures more than from cultural initiatives.

The difference between the Platonic theory and the morphic-resonance hypothesis can be illustrated by analogy with a television set. The pictures on the screen depend on the material components of the set and the energy that powers it, and also on the invisible transmissions it receives through the electromagnetic field. A sceptic who rejected the idea of invisible influences might try to explain everything about the pictures and sounds in terms of the components of the set – the wires, transistors, and so on – and the electrical interactions between them. Through careful research he would find that damaging or removing some of these components affected the pictures or sounds the set produced, and did so in a repeatable, predictable way. This discovery would reinforce his materialist belief. He would be unable to explain exactly how the set produced the pictures and sounds, but he would hope that a more detailed analysis of the components and more complex mathematical models of their interactions would eventually provide the answer. Some mutations in the components – for example, by a defect in some of the transistors – affect the pictures by changing their colours or distorting their shapes; while mutations of components in the tuning circuit cause the set to jump from one channel to another, leading to a completely different set of sounds and pictures. But this does not prove that the evening news report is produced by interactions among the TV set’s components. Likewise, genetic mutations may affect an animal’s form and behaviour, but this does not prove that form and behaviour are programmed in the genes. They are inherited by morphic resonance, an invisible influence on the organism coming from outside it, just as TV sets are resonantly tuned to transmissions that originate elsewhere.

The most commonly believed theory argues that accidental genetic mutations changed the inner wiring of the brains of Sapiens, enabling them to think in unprecedented ways and to communicate using an altogether new type of language.

Activating or inactivating any single gene, he postulated, produced only the first steps toward carcinogenesis. Cancer’s march was long and slow and proceeded though many mutations in many genes over many iterations. In genetic terms, our cells were not sitting on the edge of the abyss of cancer. They were dragged toward that abyss in graded, discrete steps.

Let us accept the possibility that there is, at death, not an abrupt cessation of energy, rather a dispersal. This seems more than reasonable to me. Mind you, I've owned a series of old cars, and I"m used to turning off the motor only to experience a series of rumblings and explosions that would shame many a volcano. This is the sort of thing I'm conceptualizing, a kind of clunky running-on. And just as some cars are more susceptible to this behavior, so people vary in the length of time, and the force with which, their energy sputters and gasps. . . My example is overly dramatic, but it is not wholly unreasonable, and it serves to make this genetic mutation a player at the evolutionary table. You see what I'm getting at: a biologically and evolutionally sound model for the soul. (I didn't say I'd achieved it.) Let's conceive of the soul as an aura that human beings wear on their backs, cumberson as a tortoise's carapace. Some are larger than others.

The appearance of new ways of thinking and communicating, between 70,000 and 30,000 years ago, constitutes the Cognitive Revolution. What caused it? We’re not sure. The most commonly believed theory argues that accidental genetic mutations changed the inner wiring of the brains of

When I learned my mom was going to die of cancer at the age of forty-five, I felt the same way. I didn’t even believe in God, but I still felt that he owed me something. I had the gall to think How dare he? I couldn’t help myself. I’m a selfish brute. I wanted what I wanted and I expected it to be given to me by a God in whom I had no faith. Because mercy had always more or less been granted me, I assumed it always would be. But it wasn’t. It wasn’t granted to my friend whose eighteen-year-old daughter was killed by a drunk driver either. Nor was it granted to my other friend who learned her baby is going to die of a genetic disorder in the not-distant future. Nor was it granted to my former student whose mother was murdered by her father before he killed himself. It was not granted to all those people who were in the wrong place at the wrong time when they came up against the wrong virus or military operation or famine or carcinogenic or genetic mutation or natural disaster or maniac. Countless people have been devastated for reasons that cannot be explained or justified in spiritual terms. To do as you are doing in asking If there were a God, why would he let my little girl have to have possibly life-threatening surgery?— understandable as that question is—creates a false hierarchy of the blessed and the damned. To use our individual good or bad luck as a litmus test to determine whether or not God exists constructs an illogical dichotomy that reduces our capacity for true compassion. It implies a pious quid pro quo that defies history, reality, ethics, and reason. It fails to acknowledge that the other half of rising—the very half that makes rising necessary— is having first been nailed to the cross. That

Other mysteries have been untangled. Redheads are known to feel pain especially acutely. This confused researchers until someone realized that the same genetic mutation that causes red hair also increases sensitivity to pain. One study found that redheaded patients require about 20 percent more general anesthesia than brunettes.

The combined effects of mutation, natural selection and the random process of genetic drift cause changes in the composition of a population. Over a sufficiently long period of time, these cumulative effects alter the population’s genetic make-up, and can thus greatly change the species’ characteristics from those of its ancestors.

He believed that the mutations were manifestations of the ancient past he had written about—evidence of a genetic code that was not completely eradicated.

The Ethics of Genetic Control. “As we learn to direct mutations medically, we should do so. Not to control when we can is immoral.

Population genetics calculations suggest that in 5 million years (one million years longer than the alleged time between Ambulocetus and Rodhocetus), animals with generation lines of about ten years (typical of whales) could substitute no more than about 1,700 mutations.6 This is not nearly enough to generate the new information that whales need for aquatic life, even assuming that all the hypothetical information-adding mutations required for this could somehow arise. (And as shown in chapter 9, real science shows that this cannot occur.)

The recent recognition that the genetic code possesses a unique capacity to resist errors caused by mutation imparts the biochemical intelligent design argument with an entirely new level of credibility. Like a giant SOS shaped with letters ablaze, the optimal nature of the genetic code signals that an Intelligent Agent used those rules to start and sustain life.

The cure for HIV?” “In 2007, a man named Timothy Ray Brown, known later as the Berlin patient, was cured of HIV. Brown was diagnosed with acute myeloid leukemia. His HIV-positive status complicated his treatment. During chemotherapy, he battled sepsis, and his physicians had to explore less traditional approaches. His hematologist, Dr. Gero Hutter, decided on a stem cell therapy: a full bone marrow transplant. Hutter actually passed over the matched bone marrow donor for a donor with a specific genetic mutation: CCR5-Delta 32. CCR5-Delta 32 makes cells immune to HIV.” “Incredible.” “Yes. At first, we thought the Delta 32 mutation must have arisen during the Black Death in Europe—about four to sixteen percent of Europeans have at least one copy. But we’ve traced it back further. We thought perhaps smallpox, but we’ve found Bronze Age DNA samples that carry it. The mutation’s origins are a mystery, but one thing is certain: the bone marrow transplant with CCR5-Delta 32 cured both Brown’s leukemia and HIV. After the transplant, he stopped taking his antiretrovirals and has never again tested positive for HIV.

Josie suffers from a very rare disease," he said. "It's caused by a genetic mutation. But the good news is that researchers are working on a gene therapy that could correct the mutation. It's still in the experimental stage, but there's a good chance it'll work. If it does, Josie could be cured." And I wondered, as I often did these days, whether Artificial Friends could help with such work.

The human has genetic adaptation to natural electromagnetic radiation. Increasing, reducing or removing the natural radiation exposures results in a sickened human that may progress onto a diseased state.

As commonly practised, philosophy is the attempt to find good reasons for conventional beliefs' 'There is no mechanism of selection in the history of ideas akin to that of the natural selection of genetic mutations in evolution' 'Human knowledge is one thing, human well-being is another.There is no predetermined harmony between the two' 'In the struggle for life, the taste for truth is a luxury-or else a disability

The appearance of new ways of thinking and communicating, between 70,000 and 30,000 years ago, constitutes the Cognitive Revolution. What caused it? We’re not sure. The most commonly believed theory argues that accidental genetic mutations changed the inner wiring of the brains of Sapiens, enabling them to think in unprecedented ways and to communicate using an altogether new type of language. We might call it the Tree of Knowledge mutation. Why did it occur in Sapiens DNA rather than in that of Neanderthals? It was a matter of pure chance, as far as we can tell. But it’s more important to understand the consequences of the Tree of Knowledge mutation than its causes. What was so special about the new Sapiens language that it enabled us to conquer the world?* It was not the first language. Every animal has some kind of language.

No matter who you are, who your parents are, you have innate genome flaws, and we do not yet know enough about the vast majority of these potential flaws, and their true risks, to make really intelligent choices.

Once a virus gets into an intensive poultry shed it can move quickly through the flock, constantly replicating itself. Any ‘errors’ or changes to the genetic code during replication don’t get repaired: this is how the virus mutates and new variant strains emerge. The tragedy is that while intensive farms provide ideal conditions for the emergence of new aggressive disease strains, wild birds can then become infected too. Experience

Everyone and everything we know and love. Thanks to a virus. We all carry mutations. Genetic mutations can give you laser vision. Or cancer. Or color blindness. Sometimes a mutation is on a DNA strand that doesn't do anything at all. And sometimes-- almost never-- a genetic mutation will cause an entire species to make an evolutionary leap forward. Think about it... a virus with powers. Sounds like something a biologist would want to protect.

When she was younger, Ellie used to believe that her invisibility was a metaphor for something else, assuming it was her awkwardness, her fear of saying or doing the wrong thing. She had thought as she grew older, more confident, wiser, she would outgrow this not being noticed. But lately, Ellie really felt like a ghost. She would be in a place, but not really there. People looked through her, past her. Her invisibility had taken on a life of its own. It wasn't a metaphor anymore, or a defense mechanism or eccentric little tic. She was actually invisible. At least, that was how it felt to her. Ellie wondered whether her parents were to blame. They were, after all, children of the sixties who had met at a love-in or lie-down or something of that sort, about which Ellie knew little except that a lot of drugs had been involved. Could Ellie's lack of physical presence be a genetic mutation caused by acid or mushrooms? Ellie grew up on their hippie commune among the highest, densest redwoods, where they dug their hands deep into the soil and grew their own food, made their own clothes. So perhaps it is there that the mystery is solved. Ellie indeed was a child of the earth, a baby of beiges and taupes and browns and muted greens. Nature doesn't scream and shout, demanding constant attention, and neither did Ellie. Maybe her invisibility was just her blending right in.

The secret to battling cancer, then, is to find means to prevent these mutations from occurring in susceptible cells, or to find means to eliminate the mutated cells without compromising normal growth. The conciseness of that statement belies the enormity of the task. Malignant growth and normal growth are so genetically intertwined that unbraiding the two might be one of the most significant scientific challenges faced by our species. Cancer is built into our genomes: the genes that unmoor normal cell division are not foreign to our bodies, but rather mutated, distorted versions of the very genes that perform vital cellular functions. And cancer is imprinted in our society: as we extend our life span as a species, we inevitably unleash malignant growth (mutations in cancer genes accumulate with aging; cancer is thus intrinsically related to age). If we seek immortality, then so, too, in a rather perverse sense, does the cancer cell.

These waves, predicted by Einstein, are ripples moving at the speed of light across the fabric of space-time, and are generated by severe gravitational disturbances, such as the collision of two black holes. And that’s exactly what was observed. The gravitational waves of the first detection were generated by a collision of black holes in a galaxy 1.3 billion light-years away, and at a time when Earth was teeming with simple, single-celled organisms. While the ripple moved through space in all directions, Earth would, after another 800 million years, evolve complex life, including flowers and dinosaurs and flying creatures, as well as a branch of vertebrates called mammals. Among the mammals, a sub-branch would evolve frontal lobes and complex thought to accompany them. We call them primates. A single branch of these primates would develop a genetic mutation that allowed speech, and that branch—Homo sapiens—would invent agriculture and civilization and philosophy and art and science. All in the last ten thousand years. Ultimately, one of its twentieth-century scientists would invent relativity out of his head, and predict the existence of gravitational waves. A century later, technology capable of seeing these waves would finally catch up with the prediction, just days before that gravity wave, which had been traveling for 1.3 billion years, washed over Earth and was detected. Yes, Einstein was a badass.

Mutations litter the chromosomes. In individual specimens of breast and colon cancer, between fifty to eighty genes are mutated; in pancreatic cancers, about fifty to sixty. Even brain cancers, which often develop at earlier ages and hence may be expected to accumulate fewer mutations, possess about forty to fifty mutated genes. Only a few cancers are notable exceptions to this rule, possessing relatively few mutations across the genome. One of these is an old culprit, acute lymphoblastic leukemia: only five or ten genetic alterations cross its otherwise pristine genomic landscape.* Indeed, the relative paucity of genetic aberrancy in this leukemia may be one reason that this tumor is so easily felled by cytotoxic chemotherapy. Scientists speculate that genetically simple tumors (i.e., those carrying few mutations) might inherently be more susceptible to drugs, and thus intrinsically more curable. If so, the strange discrepancy between the success of high-dose chemotherapy in curing leukemia and its failure to cure most other cancers has a deep biological explanation. The search for a “universal cure” for cancer was predicated on a tumor that, genetically speaking, is far from universal. In

When changes in one genetic trait are the source of selection for changes in a second, the rate of response in the latter depends in parts on the rate of change in the former, which, as a rule, is not fast. In comparison, if a cultural practice modifies selection acting on human genetic variation, then the greater the proportion of individuals in the population that exhibit the cultural trait, the stronger the selection on the gene. As a consequence, the rapid spread of a cultural practice often leads quickly to the maximally strong selection of the advantageous genetic variant, which rapidly increases in frequency. Cultural practices typically spread more quickly than genetic mutations, simply because cultural learning typically operates at faster rates than biological evolution. What does the speed with which a culturla trait spreads depend upon? Answer: the fidelity of cultural transmission. The very factor that is critical to the emergence of complex cumulative culture in humans is also a major determinant of evolutionary responses to that culture.

...to remind myself that a person can die while they're still alive, simply by not choosing to live." It's taken me a long time to understand what she'd meant by that. Worry can be pernicious. Left unchecked, it slowly bleeds the soul of joy and replaces it with fear.

Two million years ago, genetic mutations resulted in the appearance of a new human species called Homo erectus. Its emergence was accompanied by the development of a new stone tool technology, now recognised as a defining feature of this species. As long as Homo erectus did not undergo further genetic alterations, its stone tools remained roughly the same – for close to 2 million years! In contrast, ever since the Cognitive Revolution, Sapiens have been able to change their behaviour quickly, transmitting new behaviours to future generations without any need of genetic or environmental change.

Should we consider allowing parents to fully sequence their children’s genomes and potentially terminate pregnancies with such known devastating genetic mutations? We would certainly eliminate Erika’s mutation from the human gene pool—but we would eliminate Erika as well. I will not minimize the enormity of Erika’s suffering, or that of her family—but there is, indubitably, a deep loss in that. To fail to acknowledge the depth of Erika’s anguish is to reveal a flaw in our empathy. But to refuse to acknowledge the price to be paid in this trade-off is to reveal, conversely, a flaw in our humanity.

And that’s exactly what was observed. The gravitational waves of the first detection were generated by a collision of black holes in a galaxy 1.3 billion light-years away, and at a time when Earth was teeming with simple, single-celled organisms. While the ripple moved through space in all directions, Earth would, after another 800 million years, evolve complex life, including flowers and dinosaurs and flying creatures, as well as a branch of vertebrates called mammals. Among the mammals, a sub-branch would evolve frontal lobes and complex thought to accompany them. We call them primates. A single branch of these primates would develop a genetic mutation that allowed speech, and that branch—Homo sapiens—would invent agriculture and civilization and philosophy and art and science. All in the last ten thousand years. Ultimately, one of its twentieth-century scientists would invent relativity out of his head, and predict the existence of gravitational waves. A century later, technology capable of seeing these waves would finally catch up with the prediction, just days before that gravity wave, which had been traveling for 1.3 billion years, washed over Earth and was detected. Yes, Einstein was a badass.

We do know that humans got hit hard by the Toba Super Volcano. We were on the brink of extinction. That caused what population geneticists call a ‘population bottleneck.’ Some researchers believe that this bottleneck caused a small group of humans to evolve, to survive through mutation. These mutations could have led to humanity’s exponential explosion in intelligence. There’s genetic evidence for it. We know that every human being on the planet is directly descended from one man who lived in Africa around sixty thousand years ago—a person we geneticists call Y-Chromosomal Adam. In fact, everyone outside of Africa is descended from a small band of humans, maybe as few as one hundred, that left Africa about 50,000 years ago. Essentially, we’re all members of a small tribe that walked out of Africa after Toba and took over the planet. That tribe was significantly more intelligent than any other hominids in history.

A cockroach appeared just as I was about to get into the bath. It was just the right time for a cockroach to make an appearance in my life; couldn't have been better. It scuttled quickly across the porcelain, the little bugger; I looked around for a slipper, but actually I knew my chances of squashing him were small. What was the point in trying? And what good was Oon, in spite of her marvellously elastic vagina? We were already doomed. Cockroaches copulate gracelessly, with no apparent pleasure; but they also do it repeatedly and their genetic mutations are rapid and efficient. There is absolutely nothing we can do about cockroaches.

For evolution to be true, there would have been innumerable transitional forms between different types of creatures. Therefore, for every known fossil species, many more must have existed to connect it to its ancestors and descendents [sic]. This is yet another example of evolutionary conclusions coming before the evidence. Really, the claim is an implicit admission that large numbers of transitional forms are predicted, which heightens the difficulty for evolutionists, given how few there are that even they could begin to claim were candidates. . . . Evolutionists believe that mutation provides new information for selection. But no known mutation has ever increased genetic information, although there should be many examples observable today if mutation/selection were truly adequate to explain the goo-to-you theory. . . . Adaptation and natural selection are biological facts; amoeba-to-man evolution is not. Natural selection can only work on the genetic information present in a population of organisms--it cannot create new information. For example, since no known reptiles have genes for feathers, no amount of selection will produce a feathered reptile. Mutations in genes can only modify or eliminate existing structures, not create new ones. If in a certain environment a lizard survives better with smaller legs, or no legs, then varieties with this trait will be selected for. This might more accurately be called devolution, not evolution. . . . Note that even if such a mutation were ever discovered, evolutionists would still need to find hundreds more to give their theory the observational boost it desperately needs.

EVOLUTION RESTS ON three steps: (a) certain biological traits are inherited by genetic means; (b) mutations and gene recombination produce variation in those traits; (c) some of those variants confer more “fitness” than others. Given those conditions, over time the frequency of more “fit” gene variants increases in a population.

The combined effects of mutation, natural selection and the random process of genetic drift cause changes in the composition of a population. Over a sufficiently long period of time, these cumulative effects alter the population’s genetic make-up, and can thus greatly change the species’ characteristics from those of its ancestors. We

First, given what is known about the chemical basis of biology and genetics, what is the likelihood that self-reproducing life forms should have come into existence spontaneously on the early earth, solely through the operation of the laws of physics and chemistry? The second question is about the sources of variation in the evolutionary process that was set in motion once life began: In the available geological time since the first life forms appeared on earth, what is the likelihood that, as a result of physical accident, a sequence of viable genetic mutations should have occurred that was sufficient to permit natural selection to produce the organisms that actually exist?

a result, the most efficient way for evolutionary forces to spread beneficial mutations has often been to invent mutations anew rather than to import them from other populations.44 The limited migration rates between some regions of Africa over the last few thousand years has resulted in what Ralph and Coop have described as a “tessellated” pattern of population structure in Africa. Tessellation is a mathematical term for a landscape of tiles—regions of genetic homogeneity demarcated by sharp boundaries—that is expected to form when the process of homogenization due to gene exchanges among neighbors competes with the process of generating new advantageous variations in each region.

Genetic programming essentially allows computer algorithms to design themselves through a process of Darwinian natural selection. Computer code is initially generated randomly and then repeatedly shuffled using techniques that emulate sexual reproduction. Every so often, a random mutation is thrown in to help drive the process in entirely new directions.

One of the greatest problems for systems programmers (the people who write compilers, interpreters, assemblers, and other programs to be used by many people) is to figure out how to write error-detecting routines in such a way that the messages which they feed to the user whose program has a "bug" provide high-level, rather than low-level, descriptions of the problem. it is an interesting reversal that when something goes wrong in a genetic "program" (e.g., a mutation), the "bug" is manifest only to people on a high level - namely on the phenotype level, not the genotype level. Actually, modern biology uses mutations as one of its principal windows onto genetic processes, because of their multilevel traceability.

When fat is heated to frying temperatures, whether it be animal fat, such as lard, or plant fat, such as vegetable oil, toxic volatile chemicals with mutagenic properties (those able to cause genetic mutations) are released into the air.22 This happens even before the “smoke point” temperature is reached.23 If you do fry at home, good ventilation in the kitchen may reduce lung cancer risk.24 Cancer risk may also depend on what’s being fried. A study of women in China found that smokers who stir-fried meat every day had nearly three times the odds of lung cancer compared to smokers who stir-fried foods other than meat on a daily basis.25 This is thought to be because of a group of carcinogens called heterocyclic amines that are formed when muscle tissue is subjected to high temperatures.

7. The monstrous rats of Tehran In Tehran, Iran, a squad of snipers is employed to protect citizens from – rats! Do not think for a single moment that such rats could be easily dealt with by a domestic cat, because the poor cat may this time end up having its rear side kicked big time. The official statement is that the rats were exposed to radiation, which resulted in a severe genetic mutation. They now grow up to over 5 kilograms (10 pounds), and are just as cunning, aggressive and always hungry as the small sewer rats we have all seen. Although there is a disagreement to their origins within the scientific community, there is really no evidence that would point to an explanation where the ravenous, overgrown rodents came from. Good thing they are not skilled in the far-eastern martial arts… we hope.

Stafford's Hypothesis on The Transference of Existence: Even if you self-isolated, stood still, and held your breath after traveling into the past, you would still be a pebble diverting the flow of time in some way. The very transference of existence via wormholes, not interaction with past actors or events, creates paradoxes. Time Transference has three stages: 1. The distance traversed between the origin or starting point of the wormhole and the rip in the Chronosphere (space-time continuum). 2. The transference of biological material through the rip in the Chronosphere without damage to or mutation of the genetic code of the chrono-commuter. 3. Arrival at the endpoint of the time transference - the reconstruction of the chrono-commuter's genetic material and the sealing of the rip in the Chronosphere.

A modern example of this stunning knowledge of nature that Einstein has gifted us, comes from 2016, when gravitational waves were discovered by a specially designed observatory tuned for just this purpose.† These waves, predicted by Einstein, are ripples moving at the speed of light across the fabric of space-time, and are generated by severe gravitational disturbances, such as the collision of two black holes. And that’s exactly what was observed. The gravitational waves of the first detection were generated by a collision of black holes in a galaxy 1.3 billion light-years away, and at a time when Earth was teeming with simple, single-celled organisms. While the ripple moved through space in all directions, Earth would, after another 800 million years, evolve complex life, including flowers and dinosaurs and flying creatures, as well as a branch of vertebrates called mammals. Among the mammals, a sub-branch would evolve frontal lobes and complex thought to accompany them. We call them primates. A single branch of these primates would develop a genetic mutation that allowed speech, and that branch—Homo sapiens—would invent agriculture and civilization and philosophy and art and science. All in the last ten thousand years. Ultimately, one of its twentieth-century scientists would invent relativity out of his head, and predict the existence of gravitational waves. A century later, technology capable of seeing these waves would finally catch up with the prediction, just days before that gravity wave, which had been traveling for 1.3 billion years, washed over Earth and was detected. Yes, Einstein was a badass.

In the above examples, a sample of the tumor (e.g., biopsy) is tested to determine the molecular signature. Testing may be by genetic sequence tests (e.g., for BCR-ABL, mutated EGFR, or HER2 gene amplification) or tissue protein stains (e.g., for the presence of ER/PR receptors or HER2 protein overexpression). The results of the testing will guide the choice of treatment—it will be personalized for the individual.

That is why urban evolution can proceed so rapidly: the animals and plants that need to adapt to whatever new feature humans release in their urban environment do not need to wait for the right mutations to come along. Mostly, the necessary gene variants are already there, waiting in the wings of the standing genetic variation. It only takes natural selection to bring them out into the limelight, and give them a chance to shine.

The contamination of drinking water in dense urban settlements did not merely affect the number of V. cholerae circulating through the small intestines of mankind. It also greatly increased the lethality of the bacteria. This is an evolutionary principle that has long been observed in populations of disease-spreading microbes. Bacteria and viruses evolve at much faster rates than humans do, for several reasons. For one, bacterial life cycles are incredibly fast: a single bacterium can produce a million offspring in a matter of hours. Each new generation opens up new possibilities for genetic innovation, either by new combinations of existing genes or by random mutations. Human genetic change is several orders of magnitude slower; we have to go through a whole fifteen-year process of maturation before we can even think about passing our genes to a new generation.

The secret to battling cancer, then, is to find means to prevent these mutations from occurring in susceptible cells, or to find means to eliminate the mutated cells without compromising normal growth. The conciseness of that statement belies the enormity of the task. Malignant growth and normal growth are so genetically intertwined that unbraiding the two might be one of the most significant scientific challenges faced by our species.

The lineage of agriculture is a lineage of humans rearranging plant DNA. For a very long time, crossbreeding was the preferred method, but then came Mendel and his peas. As we began to understand how genetics worked, scientists tried all kinds of wild techniques to induce mutations. We dipped seeds in carcinogens and bombarded them with radiation, occasionally inside of nuclear reactors. There are over 2,250 of these mutants around; most of them are certified

The world has been changing even faster as people, devices and information are increasingly connected to each other. Computational power is growing and quantum computing is quickly being realised. This will revolutionise artificial intelligence with exponentially faster speeds. It will advance encryption. Quantum computers will change everything, even human biology. There is already one technique to edit DNA precisely, called CRISPR. The basis of this genome-editing technology is a bacterial defence system. It can accurately target and edit stretches of genetic code. The best intention of genetic manipulation is that modifying genes would allow scientists to treat genetic causes of disease by correcting gene mutations. There are, however, less noble possibilities for manipulating DNA. How far we can go with genetic engineering will become an increasingly urgent question. We can’t see the possibilities of curing motor neurone diseases—like my ALS—without also glimpsing its dangers. Intelligence is characterised as the ability to adapt to change. Human intelligence is the result of generations of natural selection of those with the ability to adapt to changed circumstances. We must not fear change. We need to make it work to our advantage. We all have a role to play in making sure that we, and the next generation, have not just the opportunity but the determination to engage fully with the study of science at an early level, so that we can go on to fulfil our potential and create a better world for the whole human race. We need to take learning beyond a theoretical discussion of how AI should be and to make sure we plan for how it can be. We all have the potential to push the boundaries of what is accepted, or expected, and to think big. We stand on the threshold of a brave new world. It is an exciting, if precarious, place to be, and we are the pioneers. When we invented fire, we messed up repeatedly, then invented the fire extinguisher. With more powerful technologies such as nuclear weapons, synthetic biology and strong artificial intelligence, we should instead plan ahead and aim to get things right the first time, because it may be the only chance we will get. Our future is a race between the growing power of our technology and the wisdom with which we use it. Let’s make sure that wisdom wins.

Looking beneath the history of one's country is like learning that alcoholism or depression runs in one's family or that suicide has occurred more often than might be usual or, with the advances of medical genetics, discovering that one has inherited the markers of BRCA mutation for breast cancer. You don't ball up in the corner with guilt or shame at these discoveries. You don't if your wise, forbit any mention of them. In fact you do the opposite. You educate yourself.

Another way is via genetic engineering. Here the germ is inserted into plasmid that has been manipulated by scientists. This type of plasmid is circular segments of DNA extracted from bacteria to serve as a vector. Scientists can add multiple genes and whatever genes they want into this plasmid. In case of vaccines, this includes a genetic piece of the vaccine germ and normally a gene for antibiotic resistance. This means that when the toxic gene is cultured inside the yeast, it has been designed with a new genetic code that makes it resistant to the antibiotic it’s coded for. The gene-plasmid combo is inserted into a yeast cell to be replicated. When the yeast replicates, the DNA from the plasmid is reproduced as a part of the yeast DNA. Once enough cells have been replicated, the genetic material in the new and improved yeast cell is extracted and put into the vaccine. Examples of this vaccine are the acellular pertussis and hepatitis B vaccines. One thing that doesn’t seem to concern scientists is the fact that the manmade genetic combination becomes the vaccine component. This mixture of intended and unintended genetic information may cause our immune system to overreact. This can be especially complicated for a child with compromised immune system. Another concern is that this new genetic code can become integrated with our own genetic material. Yeast, for instance, is very much like human DNA. It shares about one third of our proteins.

Normal cells could acquire these cancer-causing mutations through four mechanisms. The mutations could be caused by environmental insults, such as tobacco smoke, ultraviolet light, or X-rays—agents that attack DNA and change its chemical structure. Mutations could arise from spontaneous errors during cell division (every time DNA is replicated in a cell, there’s a minor chance that the copying process generates an error—an A switched to a T, G, or C, say). Mutant cancer genes could be inherited from parents, thereby causing hereditary cancer syndromes such as retinoblastoma and breast cancer that coursed through families. Or the genes could be carried into the cells via viruses, the professional gene carriers and gene swappers of the microbial world. In all four cases, the result converged on the same pathological process: the inappropriate activation or inactivation of genetic pathways that controlled growth, causing the malignant, dysregulated cellular division that was characteristic of cancer.

The bradys must hold that, on the average, cumulative selection has to add a little information to the genome at each step. But of all the mutations studied since genetics became a science, not a single one has been found that adds a little information. It is not impossible, in principle, for a mutation to add a little information, but it is improbable. The NDT was an attractive theory. Unfortunately, it is based on the false speculation that many small random mutations could build up to large evolutionary changes.

In 1993, a New York hospital launched an aggressive program to screen Ashkenazi Jews for three genetic diseases, including cystic fibrosis, Gaucher’s disease, and Tay-Sachs disease (mutations in these genes are more prevalent in the Ashkenazi population). Parents could freely choose to be screened, to undergo amniocentesis for prenatal diagnosis, and to terminate a pregnancy if the fetus was found to be affected. Since the launch of the program, not a single baby with any of these genetic diseases has been born at that hospital.

In contrast, ever since the Cognitive Revolution, Sapiens have been able to change their behaviour quickly, transmitting new behaviours to future generations without any need of genetic or environmental change. As a prime example, consider the repeated appearance of childless elites, such as the Catholic priesthood, Buddhist monastic orders and Chinese eunuch bureaucracies. The existence of such elites goes against the most fundamental principles of natural selection, since these dominant members of society willingly give up procreation. Whereas chimpanzee alpha males use their power to have sex with as many females as possible – and consequently sire a large proportion of their troop’s young – the Catholic alpha male abstains completely from sexual intercourse or raising a family. This abstinence does not result from unique environmental conditions such as a severe lack of food or want of potential mates. Nor is it the result of some quirky genetic mutation. The Catholic Church has survived for centuries, not by passing on a ‘celibacy gene’ from one pope to the next, but by passing on the stories of the New Testament and of Catholic canon law.

Let the chromosomes be represented by the keyboard of a grand piano-a very grand piano with thousands of keys. Then each key will be a gene. Every cell in the body carries a microscopic but complete keyboard in its nucleus. But each specialised cell is only permitted to sound one chord, according to its specialty-the rest of its genetic keyboard has been inactivated by scotch tape. The fertilised egg, and the first few generations of its daughter cells, had the complete keyboard at their disposal. But succesive generations have, at each 'point of no return', larger and larger areas of it covered by scotch tape. In the end, a muscle cell can only do one thing: contract-strike a single chord. The scotch tape is known in the language of genetics as the 'repressor'. The agent which strikes the key and activates the gene is an 'inducer'. A mutated gene is a key which has gone out of tune. When quite a lot of key have gone quite a lot out of tune, the result, we were asked to believe, was a much improved, wonderful new melody- a reptile transformed into a bird, or a monkey into a man. It seems that at some point the theory must have gone wrong. The point where it went wrong was the atomistic concept of the gene.

So as I said, the world was mutating," she said, prick, prick, pricking at the cloth, looking up at me once to make sure, I assume, I was listening. "From the earth sprung hateful and ugly things that flourished amid all that was lush and good. There would be no more accord among the animals now; they would follow a different order, no longer subsisting exclusively on plants but also on one another. Adam's flesh was no longer the same, though it would take centuries for disease to manifest itself, for bodies so genetically pure that a man could marry his sister to corrupt down through generations to the point where a man dare not marry even his cousin.

When the genetic code was solved, in the early 1960s, it turned out to be full of redundancy. Much of the mapping from nucleotides to amino acids seemed arbitrary—not as neatly patterned as any of Gamow’s proposals. Some amino acids correspond to just one codon, others to two, four, or six. Particles called ribosomes ratchet along the RNA strand and translate it, three bases at a time. Some codons are redundant; some actually serve as start signals and stop signals. The redundancy serves exactly the purpose that an information theorist would expect. It provides tolerance for errors. Noise affects biological messages like any other. Errors in DNA—misprints—are mutations.

But what *is* "natural"? I wonder. On one hand: variation, mutation, change, inconstancy, divisibility, flux. And on the other: constancy, permanence, indivisibility, fidelity. Bhed. Abhed. It should hardly surprise us that DNA, the molecule of contradictions, encodes an organism of contradictions. We seek constancy in heredity—and find its opposite: variation. Mutants are necessary to maintain the essence of our selves. Our genome has negotiated a fragile balance between counterpoised forces, pairing strand with opposing strand, mixing past and future, pitting memory against desire. It is the most human of all things that we possess. Its stewardship may be the ultimate test of knowledge and discernment for our species. 

Vaccinations are the application of evolutionary principles in action. If we can control the contact made between pathogen and lymphocyte populations, we can go a long way toward eliminating disease.108 It doesn’t require total annihilation but rather a control on population dynamics. Vaccines are the way we use selective cloning to keep a pathogenic population in a state of benign coexistence. The process is based on evolution, as pointed out by Nobel laureate Susumu Tonegawa: “Genes can mutate and recombine. These dynamic characteristics of genetic material are essential elements of evolution. Do they also play an important role during the development of a single multicellular organism? Our results strongly suggest that this is the case for the immune system.

Looking beneath the history of one’s country is like learning that alcoholism or depression runs in one’s family or that suicide has occurred more often than might be usual or, with the advances in medical genetics, discovering that one has inherited the markers of a BRCA mutation for breast cancer. You don’t ball up in a corner with guilt or shame at these discoveries. You don’t, if you are wise, forbid any mention of them. In fact, you do the opposite. You educate yourself. You talk to people who have been through it and to specialists who have researched it. You learn the consequences and obstacles, the options and treatment. You may pray over it and meditate over it. Then you take precautions to protect yourself and succeeding generations and work to ensure that these things, whatever they are, don’t happen again.

Genetic atomism is dead. Hereditary stability and hereditary change are both based, not on a mosaic of genes, but on the action of the gene-complex 'as a whole'. But this face-saving expression-which is now coming into increased use-is empty, like so many other holistic formulations, unless we interpolate between the gene-complex as a whole, and the individual gene, a hierarchy of genetic sub-assemblies-self-regulating holons of heredity, which control the development of organs, and also control their possible evolutionary modifications, by canalising the effects of random mutations. A hierarchy with its built-in, self-regulatory safeguards is a stable affair. It cannot be pulled in here, pulled out there, like Patou belabouring his model. It is capable of variation and change, but only in co-ordinated ways and only in limited directions.

HISTORICAL NOTE There are no nuclear power stations in Belarus. Of the functioning stations in the territory of the former USSR, the ones closest to Belarus are of the old Soviet-designed RBMK type. To the north, the Ignalinsk station, to the east, the Smolensk station, and to the south, Chernobyl. On April 26, 1986, at 1:23:58, a series of explosions destroyed the reactor in the building that housed Energy Block #4 of the Chernobyl Nuclear Power Station. The catastrophe at Chernobyl became the largest technological disaster of the twentieth century. For tiny Belarus (population: 10 million), it was a national disaster. During the Second World War, the Nazis destroyed 619 Belarussian villages along with their inhabitants. As a result of Chernobyl, the country lost 485 villages and settlements. Of these, 70 have been forever buried underground. During the war, one out of every four Belarussians was killed; today, one out of every five Belarussians lives on contaminated land. This amounts to 2.1 million people, of whom 700,000 are children. Among the demographic factors responsible for the depopulation of Belarus, radiation is number one. In the Gomel and Mogilev regions, which suffered the most from Chernobyl, mortality rates exceed birth rates by 20%. As a result of the accident, 50 million Ci of radionuclides were released into the atmosphere. Seventy percent of these descended on Belarus; fully 23% of its territory is contaminated by cesium-137 radionuclides with a density of over 1 Ci/km2. Ukraine on the other hand has 4.8% of its territory contaminated, and Russia, 0.5%. The area of arable land with a density of more than 1 Ci/km2 is over 18 million hectares; 2.4 thousand hectares have been taken out of the agricultural economy. Belarus is a land of forests. But 26% of all forests and a large part of all marshes near the rivers Pripyat, Dniepr, and Sozh are considered part of the radioactive zone. As a result of the perpetual presence of small doses of radiation, the number of people with cancer, mental retardation, neurological disorders, and genetic mutations increases with each year. —“Chernobyl.” Belaruskaya entsiklopedia On April 29, 1986, instruments recorded high levels of radiation in Poland, Germany, Austria, and Romania. On April 30, in Switzerland and northern Italy. On May 1 and 2, in France, Belgium, the Netherlands, Great Britain, and northern Greece. On May 3, in Israel, Kuwait, and Turkey. . . . Gaseous airborne particles traveled around the globe: on May 2 they were registered in Japan, on May 5 in India, on May 5 and 6 in the U.S. and Canada. It took less than a week for Chernobyl to become a problem for the entire world. —“The Consequences of the Chernobyl Accident in Belarus.” Minsk, Sakharov International College on Radioecology The fourth reactor, now known as the Cover, still holds about twenty tons of nuclear fuel in its lead-and-metal core. No one knows what is happening with it. The sarcophagus was well made, uniquely constructed, and the design engineers from St. Petersburg should probably be proud. But it was constructed in absentia, the plates were put together with the aid of robots and helicopters, and as a result there are fissures. According to some figures, there are now over 200 square meters of spaces and cracks, and radioactive particles continue to escape through them . . . Might the sarcophagus collapse? No one can answer that question, since it’s still impossible to reach many of the connections and constructions in order to see if they’re sturdy. But everyone knows that if the Cover were to collapse, the consequences would be even more dire than they were in 1986. —Ogonyok magazine, No. 17, April 1996

gene, the mutation of whose DNA building blocks accelerated after the split between humans and chimpanzees, around 5.5 million years ago. The theory has also been put forward that the human brain is still evolving, on the grounds that a genetic variant of ASPM is thought to have originated only 5,800 years ago and then spread rapidly through the population. A genetic variant of the microcephalin gene (D allele of MCPH1), which regulates brain size, is thought to have only entered the DNA of Homo sapiens during the last ice age, around 37,000 years ago—yet 70 percent of the current world population carries this variant. A rapid increase of this kind is only possible if a variant confers a clear evolutionary advantage. Genes whose mutations are associated with human language have also been found. Mutations of the FOXP2 gene cause language and speech disorders that run in families. And ASPM and microcephalin also appear to have a linguistic connection.

Let's look at one more quick example of modern evolution at work. In the early 1800s, light-colored lichens covered many of the trees in the English countryside. The peppered moth was a light-colored insect that blended in unnoticeably with the lichens. Predators had great difficulty distinguishing the peppered moth from its background environment, so the moths easily survived and reproduced. Then the Industrial Revolution came to the English country- side. Coal-burning factories turned the lichens a sooty black. The light-colored peppered moth became clearly visible. Most of them were eaten. But because of genetic variation and mutation, a few peppered moths displayed a slightly darker color. These darker moths were better able to blend in with the sooty lichens, and so lived to produce other darker-colored moths. In little over a hun- dred years, successive generations of peppered moths evolved from almost completely white to completely black. Natural selec- tion, rather than "random accident," guided the moth's evolution- ary progress.

With the rise of molecular genetics, it has become possible to search for possible changes (mutations, polymorphisms) in target genes. Much effort has gone into investigating variations in genes that contribute to serotonin transmission, because serotonin-related drugs have antidepressant and anxiolytic properties. This assumes, however, that the treatment mechanism is the same mechanism that gives rise to the disorder.53 Although this is consistent with the old chemical imbalance hypothesis, it is not a conclusion that should simply be accepted without careful assessment. Nevertheless, studies of the genetic control of serotonin have found interesting results. For example, people with a certain variant (polymorphism) of a gene controlling a protein involved in serotonin transmission are more reactive to threatening stimuli, and this hyperreactivity is associated with increased amygdala activity during the threat.54 Further, it has been reported that this variant of the gene can account for 7 percent to 9 percent of the inheritance of anxiety.55

By the end of this decade, permutations and combinations of genetic variants will be used to predict variations in human phenotype, illness, and destiny. Some diseases might never be amenable to such a genetic test, but perhaps the severest variants of schizophrenia or heart disease, or the most penetrant forms of familial cancer, say, will be predictable by the combined effect of a handful of mutations. And once an understanding of "process" has been built into predictive algorithms, the interactions between various gene variants could be used to compute ultimate effects on a whole host of physical and mental characteristics beyond disease alone. Computational algorithms could determine the probability of the development of heart disease or asthma or sexual orientation and assign a level of relative risk for various fates to each genome. The genome will thus be read not in absolutes, but in likelihoods-like a report card that does not contain grades but probabilities, or a resume that does not list past experiences but future propensities. It will become a manual for previvorship.

Viruses, for instance, perform a really irritating function of intermingling the DNA from every species on Earth with every other. As Richard Lewontin puts it . . . It used to be thought that new functions had to arise by mutations of the genes already possessed by a species and that the only way such mutations could spread was by the normal processes of reproduction. It is now clear that genetic material has moved during evolution from species to species by means of retroviruses and other transposable particles. . . . What is so extraordinary in its implications for evolution is that transposition can occur between forms of life that are quite different, between distantly related vertebrates, for example, or even between plants and bacteria. . . . Thus, the assumption that species are on independent evolutionary pathways, once they have diverged from each other and can no longer interbreed, is incorrect. All life-forms are in potential genetic contact and genetic exchanges between them are going on. . . . The evolutionary “tree of life” seems the wrong metaphor. Perhaps we should think of it as an elaborate bit of macramé.16

The Case of the Eyeless Fly The fruit fly has a mutant gene which is recessive, i.e., when paired with a normal gene, has no discernible effect (it will be remembered that genes operate in pairs, each gene in the pair being derived from one parent). But if two of these mutant genes are paired in the fertilised egg, the offspring will be an eyeless fly. If now a pure stock of eyeless flies is made to inbreed, then the whole stock will have only the 'eyeless' mutant gene, because no normal gene can enter the stock to bring light into their darkness. Nevertheless, within a few generations, flies appear in the inbred 'eyeless' stock with eyes that are perfectly normal. The traditional explanation of this remarkable phenomenon is that the other members of the gene-complex have been 'reshuffled and re-combined in such a way that they deputise for the missing normal eye-forming gene.' Now re-shuffling, as every poker player knows, is a randomising process. No biologist would be so perverse as to suggest that the new insect-eye evolved by pure chance, thus repeating within a few generations an evolutionary process which took hundreds of millions of years. Nor does the concept of natural selection provide the slightest help in this case. The re-combination of genes to deputise for the missing gene must have been co-ordinated according to some overall plan which includes the rules of genetic self-repair after certain types of damage by deleterious mutations. But such co-ordinative controls can only operate on levels higher than that of individual genes. Once more we are driven to the conclusion that the genetic code is not an architect's blueprint; that the gene-complex and its internal environment form a remarkably stable, closely knit, self-regulating micro-hierarchy; and that mutated genes in any of its holons are liable to cause corresponding reactions in others, co-ordinated by higher levels. This micro-hierarchy controls the pre-natal skills of the embryo, which enable it to reach its goal, regardless of the hazards it may encounter during development. But phylogeny is a sequence of ontogenies, and thus we are confronted with the profound question: is the mechanism of phylogeny also endowed with some kind of evolutionary instruction booklet? Is there a strategy of the evolutionary process comparable to the 'strategy of the genes'-to the 'directiveness' of ontogeny (as E.S. Russell has called it)?

There are many examples where species share common plastic traits. What appears to be convergence may just be the plastic response of the organism to its environment. Examples include the following: Limbs that protrude from an animal’s body have more surface area per unit mass than the rest of the body. In cold weather the animal loses more heat per unit mass from these limbs than from other parts of the body. In many species the tails and legs are shorter for those living in colder climates and larger for those in warmer climates. Gulls’ wings are shorter in cold climates than in warm. Hares and foxes also have shorter ears in cold climates than in warm. Eskimos have shorter arms and legs than do people living in warmer climates. . . . Jodan’s rule: Many species of fish tend to have more vertebrae when they live in cold water than do the same species living in warm water. These differences have been shown to depend on the temperature at which the fish have been reared. What these rules show is not convergence. They show that different species adopt the same anatomical strategies when they have to cope with the same environmental conditions. We have seen that these strategies cannot come from random mutations. It is much more reasonable to say they come from environmental cues acting on the genetic program.

Working independently, Baltimore and Temin discovered an enzyme found in retroviruses that could build DNA from an RNA template. They called the enzyme reverse transcriptase-"reverse" because it inverted the normal direction of information flow: from RNA back to DNA, or from a gene's message backward to a gene, thereby violating Crick's "central dogma" (that genetic information only moved from genes to messages, but never backward). Using reverse transcriptase, ever RNA in a cell could be used as a template to build its corresponding gene. A biologist could thus generate a catalog, or "library" of all "active" genes in a cell-akin to a library of books grouped by subject. There would be a library of genes for T cells and another for red blood cells, a library for neurons in the retina, for insulin-secreting cells of the pancreas, and so forth. By comparing libraries derived from two cells-a T cell and a pancreas cell, say-an immunologist could fish out genes that were active in one cell and not the other (e.g., insulin or the T cell receptor). Once identified, that gene could be amplified a millionfold in bacteria. The gene could be isolated and sequenced, its RNA and protein sequence determined, its regulatory regions identified; it could be mutated an inserted into a different cell to decipher the gene's structure and function. In 1984 this technique was deployed to clone the T cell receptor-a landmark achievement in immunology.

When we go to the doctor, he or she will not begin to treat us without taking our history—and not just our history but that of our parents and grandparents before us. The doctor will not see us until we have filled out many pages on a clipboard that is handed to us upon arrival. The doctor will not hazard a diagnosis until he or she knows the history going back generations. As we fill out the pages of our medical past and our current complaints, what our bodies have been exposed to and what they have survived, it does us no good to pretend that certain ailments have not beset us, to deny the full truths of what brought us to this moment. Few problems have ever been solved by ignoring them. Looking beneath the history of one’s country is like learning that alcoholism or depression runs in one’s family or that suicide has occurred more often than might be usual or, with the advances in medical genetics, discovering that one has inherited the markers of a BRCA mutation for breast cancer. You don’t ball up in a corner with guilt or shame at these discoveries. You don’t, if you are wise, forbid any mention of them. In fact, you do the opposite. You educate yourself. You talk to people who have been through it and to specialists who have researched it. You learn the consequences and obstacles, the options and treatment. You may pray over it and meditate over it. Then you take precautions to protect yourself and succeeding generations and work to ensure that these things, whatever they are, don’t happen again.

Neo-Darwinism and Mutations In order to find a solution, Darwinists advanced the "Modern Synthetic Theory," or as it is more commonly known, Neo-Darwinism, at the end of the 1930s. Neo- Darwinism added mutations, which are distortions formed in the genes of living beings due to such external factors as radiation or replication errors, as the "cause of favorable variations" in addition to natural mutation. Today, the model that stands for evolution in the world is Neo-Darwinism. The theory maintains that millions of living beings formed as a result of a process whereby numerous complex organs of these organisms (e.g., ears, eyes, lungs, and wings) underwent "mutations," that is, genetic disorders. Yet, there is an outright scientific fact that totally undermines this theory: Mutations do not cause living beings to develop; on the contrary, they are always harmful. The reason for this is very simple: DNA has a very complex structure, and random effects can only harm it. The American geneticist B. G. Ranganathan explains this as follows: First, genuine mutations are very rare in nature. Secondly, most mutations are harmful since they are random, rather than orderly changes in the structure of genes; any random change in a highly ordered system will be for the worse, not for the better. For example, if an earthquake were to shake a highly ordered structure such as a building, there would be a random change in the framework of the building which, in all probability, would not be an improvement. Not surprisingly, no mutation example, which is useful, that is, which is observed to develop the genetic code, has been observed so far. All mutations have proved to be harmful. It was understood that mutation, which is presented as an "evolutionary mechanism," is actually a genetic occurrence that harms living things, and leaves them disabled. (The most common effect of mutation on human beings is cancer.) Of course, a destructive mechanism cannot be an "evolutionary mechanism." Natural selection, on the other hand, "can do nothing by itself," as Darwin also accepted. This fact shows us that there is no "evolutionary mechanism" in nature. Since no evolutionary mechanism exists, no such any imaginary process called "evolution" could have taken place.

A note of caution: epigenetics is also on the verge of transforming into a dangerous idea. Epigenetic modifications of genes can potentially superpose historical and environmental information on cells and genomes—but this capacity is speculative, limited, idiosyncratic, and unpredictable: a parent with an experience of starvation produces children with obesity and overnourishment, while a father with the experience of tuberculosis, say, does not produce a child with an altered response to tuberculosis. Most epigenetic “memories” are the consequence of ancient evolutionary pathways, and cannot be confused with our longing to affix desirable legacies on our children. As with genetics in the early twentieth century, epigenetics is now being used to justify junk science and enforce stifling definitions of normalcy. Diets, exposures, memories, and therapies that purport to alter heredity are eerily reminiscent of Lysenko’s attempt to “reeducate” wheat using shock therapy. Mothers are being asked to minimize anxiety during their pregnancy—lest they taint all their children, and their children, with traumatized mitochondria. Lamarck is being rehabilitated into the new Mendel. These glib notions about epigenetics should invite skepticism. Environmental information can certainly be etched on the genome. But most of these imprints are recorded as “genetic memories” in the cells and genomes of individual organisms—not carried forward across generations. A man who loses a leg in an accident bears the imprint of that accident in his cells, wounds, and scars—but does not bear children with shortened legs. Nor has the uprooted life of my family seem to have burdened me, or my children, with any wrenching sense of estrangement. Despite Menelaus’s admonitions, the blood of our fathers is lost in us—and so, fortunately, are their foibles and sins. It is an arrangement that we should celebrate more than rue. Genomes and epigenomes exist to record and transmit likeness, legacy, memory, and history across cells and generations. Mutations, the reassortment of genes, and the erasure of memories counterbalance these forces, enabling unlikeness, variation, monstrosity, genius, and reinvention—and the refulgent possibility of new beginnings, generation upon generation.

The key point is that these patterns, while mostly stable, are not permanent: certain environmental experiences can add or subtract methyls and acetyls, changing those patterns. In effect this etches a memory of what the organism was doing or experiencing into its cells—a crucial first step for any Lamarck-like inheritance. Unfortunately, bad experiences can be etched into cells as easily as good experiences. Intense emotional pain can sometimes flood the mammal brain with neurochemicals that tack methyl groups where they shouldn’t be. Mice that are (however contradictory this sounds) bullied by other mice when they’re pups often have these funny methyl patterns in their brains. As do baby mice (both foster and biological) raised by neglectful mothers, mothers who refuse to lick and cuddle and nurse. These neglected mice fall apart in stressful situations as adults, and their meltdowns can’t be the result of poor genes, since biological and foster children end up equally histrionic. Instead the aberrant methyl patterns were imprinted early on, and as neurons kept dividing and the brain kept growing, these patterns perpetuated themselves. The events of September 11, 2001, might have scarred the brains of unborn humans in similar ways. Some pregnant women in Manhattan developed post-traumatic stress disorder, which can epigenetically activate and deactivate at least a dozen genes, including brain genes. These women, especially the ones affected during the third trimester, ended up having children who felt more anxiety and acute distress than other children when confronted with strange stimuli. Notice that these DNA changes aren’t genetic, because the A-C-G-T string remains the same throughout. But epigenetic changes are de facto mutations; genes might as well not function. And just like mutations, epigenetic changes live on in cells and their descendants. Indeed, each of us accumulates more and more unique epigenetic changes as we age. This explains why the personalities and even physiognomies of identical twins, despite identical DNA, grow more distinct each year. It also means that that detective-story trope of one twin committing a murder and both getting away with it—because DNA tests can’t tell them apart—might not hold up forever. Their epigenomes could condemn them. Of course, all this evidence proves only that body cells can record environmental cues and pass them on to other body cells, a limited form of inheritance. Normally when sperm and egg unite, embryos erase this epigenetic information—allowing you to become you, unencumbered by what your parents did. But other evidence suggests that some epigenetic changes, through mistakes or subterfuge, sometimes get smuggled along to new generations of pups, cubs, chicks, or children—close enough to bona fide Lamarckism to make Cuvier and Darwin grind their molars.