Genes Best Quotes

To recognize that the greatest error is not to have tried and failed, but that in trying, we did not give it our best effort

Being mortal is about the struggle to cope with the constraints of our biology, with the limits set by genes and cells and flesh and bone. Medical science has given us remarkable power to push against these limits, and the potential value of this power was a central reason I became a doctor. But again and again, I have seen the damage we in medicine do when we fail to acknowledge that such power is finite and always will be. We’ve been wrong about what our job is in medicine. We think our job is to ensure health and survival. But really it is larger than that. It is to enable well-being. And well-being is about the reasons one wishes to be alive. Those reasons matter not just at the end of life, or when debility comes, but all along the way. Whenever serious sickness or injury strikes and your body or mind breaks down, the vital questions are the same: What is your understanding of the situation and its potential outcomes? What are your fears and what are your hopes? What are the trade-offs you are willing to make and not willing to make? And what is the course of action that best serves this understanding?

I was conceived because it would be good for my House to have an heir and because my parents' genes ticked the right set of boxes. You were probably conceived because your parents loved each other." "According to our mother," Bern said, "he was conceived because she was too wasted to remember a rubber." Mad Rogan stopped chewing. "I was conceived because my mother skipped bail. Her boyfriend at the time threatened to call the cops on her so she had to do something to keep him from doing it," Bern said helpfully. Awesome. Just the right kind of information to share. "Aunt Giselea isn't the best mother," I said. "There's one in every family.

The brain is heavily influenced by genes. But from birth through young adulthood, the part of the human brain that most defines us (frontal cortex) is less a product of the genes with which you started life than of what life has thrown at you. Because it is the last to mature, by definition the frontal cortex is the brain region least constrained by genes and most sculpted by experience. This must be so, to be the supremely complex social species that we are. Ironically, it seems that the genetic program of human brain development has evolved to, as much as possible, free the frontal cortex from genes.

Why is it that our automatic, intuitive moral judgments tend to be nonutilitarian? Because, as Greene states in his book, “Our moral brains evolved to help us spread our genes, not to maximize our collective happiness.

He only knew that he had lived up to his best impulse, and that is all any one can do.

That was when I found out that the best way in the world to make yourself feel better when you have hit bottom is to try to get somebody else to feel better. There are certain things in life that are truly worth knowing, and that is one of the big ones.

We have treatments for disturbed persons, Nicholas. But, at least for the time being, we have no treatment for disturbing persons.

There is no such thing as good enough. You, your team, and your equipment must be the best. That is how you will win victories.

I just wanted to thank you," he says, his voice low. "A group of scientists told you that my genes were damaged, that there was something wrong with me - they showed you test results that proved it. And I even started to believe it." He touches my face, his thumb skimming my cheekbone, and his eyes on mine, intense and insistent. "You never believed it," he says. "Not for a second. You always insisted that I was... I don't know, whole." I cover his hand with my own. "Well, you are." "No one has ever told me that before," he says softly. "It's what you deserve to hear," I say firmly, my eyes going cloudy with tears. "That you're whole, that you're worth loving, that you're the best person I've ever known.

To recognize that the greatest error is not to have tried and failed, but that in trying, we did not give it our best effort.

In a reductionist view, understanding something complex requires breaking it down into its components; understand those parts, add them together, and you’ll understand the big picture. And in this reductionist world, to understand cells, organs, bodies, and behavior, the best constituent part to study is genes.

The best offense is a good defense, but a bad defense is offensive.

For every bad man and woman I have ever known, I have met . . . an overwhelming number of thoroughly clean and decent people who still believe in God and cherish high ideals, and it is upon the lives of these people that I base what I write. To contend that this does not produce a picture true to life is idiocy. It does. It produces a picture true to ideal life; to the best that good men and good women can do at level best. I care very little for the . . . critics who proclaim that there is no such thing as a moral man, and that my pictures of life are sentimental and idealized. They are! And I glory in them! They are straight, living pictures from the lives of men and women of morals, honor, and loving kindness. . . . Such a big majority of book critics and authors have begun to teach, whether they really believe it or not, that no book is true to life unless it is true to the worst in life.

probably the most important fact about genetics and culture is the delayed maturation of the frontal cortex—the genetic programming for the young frontal cortex to be freer from genes than other brain regions, to be sculpted instead by environment, to sop up cultural norms. To hark back to a theme from the first pages of this book, it doesn’t take a particularly fancy brain to learn how to motorically, say, throw a punch. But it takes a fancy, environmentally malleable frontal cortex to learn culture-specific rules about when it’s okay to throw punches.

Religion is still the very best way to get someone to accept something unabashedly ridiculous.

In all probability the Human Genome Project will, someday, find that I carry some recessive gene for optimism, because despite all my best efforts I still can't scrape together even a couple days of hopelessness. Future scientists will call it the Pollyanna Syndrome, and if forced to guess, I'd say that mine has been a way-long case history of chasing rainbows.

How’s this for fascinating: Heritability of various aspects of cognitive development is very high (e.g., around 70 percent for IQ) in kids from high–socioeconomic status (SES) families but is only around 10 percent in low-SES kids. Thus, higher SES allows the full range of genetic influences on cognition to flourish, whereas lower-SES settings restrict them. In other words, genes are nearly irrelevant to cognitive development if you’re growing up in awful poverty—poverty’s adverse effects trump the genetics.fn24 Similarly, heritability of alcohol use is lower among religious than nonreligious subjects—i.e., your genes don’t matter much if you’re in a religious environment that condemns drinking. Domains like these showcase the potential power of classical behavior genetics.

I have no way of knowing whether you, who eventually will read this record, like stories or not. If you do not, no doubt you have turned these pages without attention. I confess that I love them. Indeed, it often seems to me that of all the good things in the world, the only ones humanity can claim for itself are stories and music; the rest, mercy, beauty, sleep, clean water and hot food (as the Ascian would have said) are all the work of the Increate. Thus, stories are small things indeed in the scheme of the universe, but it is hard not to love best what is our own—hard for me, at least.

But perhaps the most damning argument came from nature herself. Had David followed his own advice to look to nature for truth, he would have seen it. This dazzling, feathery, squawking, gurgling mound of counterevidence. Animals can outperform humans on nearly every measure supposedly associated with our superiority. There are crows that have better memories than us, chimps with better pattern-recognition skills, ants that rescue their wounded, and blood flukes with higher rates of monogamy. When you actually examine the range of life on Earth, it takes a lot of acrobatics to sort it into a single hierarchy with humans at the top. We don’t have the biggest brain or the best memory. We’re not the fastest or the strongest or the most prolific. We’re not the only ones that mate for life, that show altruism, use tools, language. We don’t have the most copies of genes in circulation. We aren’t even the newest creation on the block.

People see essentialism embedded in bloodlines—i.e., genes.

Who would appreciate such candor? No one. None of us really likes honesty. We prefer deception –but only when it is unabashedly flattering or artfully camouflaged. Groups seem to need to believe that they are superior to others and that they have a purpose greater than just passing along their genes to the next generation. Individuals seem to need similar delusions – about who they are and why they do what they do. They need heroes, however fraudulent… Studies show that people are more likely to accept the opinion of a confident con man than the cautious view of someone who actually knows what he is talking about. And professionals who form overconfident opinions on the basis of incorrect readings of the facts are more likely to succeed than their more competent peers who display greater doubt. What’s more, deception works best, according to studies by psychologists, when the person doing the deceiving is fool enough to be deceived, too; that is, when he believes his own lies. That is why incompetent leaders – who are naïve enough to fall for their own guff – are such a danger to civilized life. If they are modern leaders, they must also delude themselves into thinking they know how to make the world a better place. Invariably, the answers they propose to problems are ones that bubble up from their own vanity, the essence of which is to make the rest of the world look just like them!

Humans are built to move. We evolved under conditions that required daily intense physical activity, and even among individuals with lower physical potential, that hard-earned genotype is still ours today. The modern sedentary lifestyle leads to the inactivation of the genes related to physical performance, attributes that were once critical for survival and which are still critical for the correct, healthy expression of the genotype. The genes are still there, they just aren't doing anything because the body is not stressed enough to cause a physiological adaptation requiring their activation. The sedentary person's heart, lungs, muscles, bones, nerves and brain all operate far below the level at which they evolved to function, and at which they still function best.

Is he a dread genetic determinist, or a dread environmental determinist? He is neither, of course, for both these species of bogeyman are as mythical as werewolves. By increasing the information we have about the various causes of the constraints that limit our current opportunities, he has increased our powers to avoid what we want to avoid, prevent what we want to prevent. Knowledge of the roles of our genes, and the genes of the other species around us, is not the enemy of human freedom, but one of its best friends.

Don't!" cried Jamie. "Don't be bitter, Margaret. We don't know why, we never can know why things happen in this world exactly as they do; but this we know: We know that God is in His Heaven, that He is merciful to the extent of ordaining mercy; we know that if we disobey and take our own way and run contrary to His commandments, we are bitterly punished. And it is the most pitiful of laws that no man or woman can take their punishment alone in this world. It is the law that none of us can suffer without making someone else suffer, but in some way it must be that everything works out for the best, even if we can't possibly see how that could be when things are happening that hurt us so.

Today, of course, there’s no need to forage and hunt to survive. Yet our genes are coded for this activity, and our brains are meant to direct it. Take that activity away, and you’re disrupting a delicate biological balance that has been fine-tuned over half a million years. Quite simply, we need to engage our endurance metabolism to keep our bodies and brains in optimum condition. The ancient rhythms of activity ingrained in our DNA translate roughly to the varied intensity of walking, jogging, running, and sprinting. In broad strokes, then, I think the best advice is to follow our ancestors’ routine: walk or jog every day, run a couple of times a week, and then go for the kill every now and then by sprinting.

She is the best-dressed woman in the county, and the best looking," said Mrs. Bates, "and that's all there is to her.

Ask not what a gene does. Ask what it does in a particular environment and when expressed in a particular network of other genes

Thus transcription factors regulate genes. What regulates transcription factors? The answer devastates the concept of genetic determinism: the environment.

I believe the best way to get an answer to prayer is to work for it,

Beginning empty-handed and alone frightens the best of men. It also speaks volumes of just how sure they are that God is with them.

The problem with the gene pool is that there is no lifeguard.

And then there was that key point in On the Origin of Species. That crucial point that somehow both David and before him Francis Galton had missed. What does Darwin say is the best way of building a strong species, of allowing it to endure into the future, to withstand the blows of Chaos in all her mighty forms—flood, drought, rising sea levels, fluctuating temperatures, invasions of competitors, predators, pests? Variation. Variation in genes, and hence in behavior and physical traits. Homogeneity is a death sentence. To rid a species of its mutants and outliers is to make that species dangerously vulnerable to the elements.

We can now give you a biological reason why cramming doesn’t work,” says Dr. Tully. The best way to prepare for a final exam is to mentally review the material periodically during the day, until the material becomes part of your long-term memory. This may also explain why emotionally charged memories are so vivid and can last for decades. The CREB repressor gene is like a filter, cleaning out useless information. But if a memory is associated with a strong emotion, it can either remove the CREB repressor gene or increase levels of the CREB activator gene.

Consider this: the human genome codes for about 1,500 different TFs, contains 4,000,000 TF-binding sites, and the average cell uses about 200,000 such sites to generate its distinctive gene-expression profile.5 This is boggling.

Far from undermining marriage, gay and lesbian couples seeking marriage for themselves are perhaps the institution's best friends. At a time when marriage is seen as less desirable and less necessary for straight couples, gay and lesbian people are lining up at town halls and church doors to participate in this traditional and long-standing institution.

Because it is the last to mature, by definition the frontal cortex is the brain region least constrained by genes and most sculpted by experience. This must be so, to be the supremely complex social species that we are. Ironically, it seems that the genetic program of human brain development has evolved to, as much as possible, free the frontal cortex from genes.

One stretch of the gene is repeated a variable number of times, and the version with seven repeats (the “7R” form) produces a receptor protein that is sparse in the cortex and relatively unresponsive to dopamine. This is the variant associated with a host of related traits—sensation and novelty seeking, extroversion, alcoholism, promiscuity, less sensitive parenting, financial risk taking, impulsivity, and, probably most consistently, ADHD (attention-deficit/hyperactivity disorder).

If you want to know if your kid is going to be fast, the best genetic test right now is a stopwatch. Take him to the playground and have him face the other kids.' Foster's point is that, despite the avant-garde allure of genetic testing, gauging speed indirectly is foolish and inaccurate compared with testing it directly - like measuring a man's height by dropping a ball from a roof and using the time it takes to hit him in the head to determine how tall he is. Why not just use a tape measure?

genes and fetal environment are relevant. But most important, recall the logic of collapsing different types of trauma into a single category. What counts is the sheer number of times a child is bludgeoned by life and the number of protective factors.

I had come to wonder about the true nature of commitment. In fact, it's not about time. It's not about reliability and predictability. Commitment is about depth. It's about effort. It's about passion. It's about wanting to be in a certain place, and not somewhere else. Of course time is involved; it would be naïve and illogical to suggest otherwise. But commitment is best measured not by the time one is willing to give up but, more accurately, by the energy one wants to put in, by how present one is.

Thus, for our purposes, genes aren’t about inevitability. Instead they’re about context-dependent tendencies, propensities, potentials, and vulnerabilities. All embedded in the fabric of the other factors, biological and otherwise, that fill these pages.

As I learned about the consequences of my food choices and as I recognized that I didn't have to eat animals, and that eating animals caused the animals to suffer, it caused an enormous footprint on our planet, and it wasn't healthy, it made since to go vegan. And, it's one of the best decisions I've ever made, and I think most people who've decided to go vegan share a similar experience. It's very empowering. And, when I went vegan I actually started eating a wide variety of foods I had never tried before. Different ethnic foods. You also start combining things in different ways, you start becoming more creative in the kitchen. But I went vegan just because it seemed to make sense, and it was aligned with my own values, because I didn't want to support this system that was so abusive to animals, and wasting and squandering so many scarce resources on our planet. And it was also healthier, so it was in my interest to eat food that was plant-based instead of animal-based. Living a vegan lifestyle makes a lot of sense.

Lots of work has examined the genes involved, most broadly showing that variants that produce lowered dopamine signaling (less dopamine in the synapse, fewer dopamine receptors, or lower responsiveness of these receptors) are associated with sensation seeking, risk taking, attentional problems, and extroversion. Such individuals have to seek experiences of greater intensity to compensate for the blunted dopamine signaling.

Now it might be suggested that cloning is sometimes worse because, where it is done for the sake of the person cloned, it is also an act of narcissism. The being cloned wants a physical replica of himself. Thus the clone is treated as a means to the narcissistic ends of the person cloned. Now there might indeed be some people who will wish to have themselves cloned for narcissistic reasons, but others may want to be cloned for other reasons (perhaps because it is their only or best chance of reproducing). Moreover, the argument from narcissism assumes that ordinary reproduction is not narcissistic. But why should we think that that is always the case? There could well be something self-adulating in the desire to produce offspring. Those who adopt children or do not have children at all could advance the narcissistic objection against non-clonal reproduction with as much (or as little) force as non-clonal reproducers do in criticizing cloning. They could argue that it is narcissistic for a couple to want to create a child in their combined image, from a mixture of their genes. The point is that both cloning and usual methods of reproduction may be narcissistic, but neither is it the case that each kind of reproduction must necessarily be characterized in this way.

Man is neither unique nor central nor necessarily here to stay. But he is a product of circumstances special to the point of disbelief. And if man in his current predicament seeks a fair mystique to see him through, then I can only suggest that he consider his genes. For they are marked. They are graven by luck beyond explanation. They are stamped by forces that we shall never know. But even so, in the hieroglyph of the human emergence certain symbols must stand for all to read: Change is the elixir of the human circumstance, and acceptance of challenge the way of our kind. We are bad-weather animals, disaster’s fairest children. For the soundest of evolutionary reasons man appears at his best when times are worst.

İnsancı ve şiddet içermeyen bir ütopya, toplum diğer hayvanları eşitliğe dahil etmedikçe ve onlara doğru adil ve eşit bir davranış geliştirmedikçe gene şiddet dolu bir karşı ütopya ve bir ikiyüzlülük olarak kalacak. İnsancı demokrasi türcü bir ikiyüzlülüktür. İnsancılık büyük bir kabileciliktir.

As a working definition of art, I lean toward Tolstoy's: "Art is a human activity having for it's purpose the transmission to other of the highest and best feelings to which mankind has risen." It seems to me that, regarding agrarian art, the farther it moves away from the natural world, especially when the main goal is money profits, the more difficult it becomes for it to reflect "the highest and best feelings" of humanity. The same is true of, of course, of agriculture itself. The farther it tries to remove itself from nature in search of money, the more it moves away from the highest and healthiest kinds of food.

For women: In your autumn years, having a successful career behind you will be nothing compared to having a large family, with grandchildren and everything else that comes with it. This is also the best and most natural method for ensuring your retirement benefits — a few decades from now, your children and grandchildren will be far more inclined to take care of you than the rapidly crumbling European welfare states will. Besides, passing your genes on is a far worthier goal in life than slaving for some multinational corporation, which will forget all about you the second you retire. Furthermore, the plummeting birth rates of Europe must be reversed. Make sure to have at least three children, and raise them well. In this regard, the future of Europe rests squarely in your hands.

I’ve learned that while the finance goals are important, they’re not the most important. Finance can hit all our objectives, and the company still can fail. After all, the best accounts receivables team on the planet can’t save us if we’re in the wrong market with the wrong product strategy with an R&D team that can’t deliver.

These chaps everyone’s been shouting at to change things, they’re the very chaps that do so well as things are. Think they’re going to make new rules for a game they always win? Not ruddy likely.

The Blind Watchmaker, by the same producer, gave me a new respect for his profession. At their best, Horizon producers (some of their programmes can be seen in America, often repackaged under the name Nova)

It is a wonderful quirk of our species that the incentives of social life don’t reward strictly ruthless behavior. Leaders who are too domineering are often penalized. Rampant lying and cheating are often caught and punished. Freeloaders frequently get the boot. At the same time, people are often positively rewarded—with friendship, social status, a better reputation—for their service to others. As if our oversized brains and hairless skin didn’t make us an uncanny enough species, our genes long ago decided that, in the relentless competition to survive and reproduce, their best strategy was to build ethical brains.

Asilomar’s lack of focus on ethical issues bothered many religious leaders. That prompted a letter to President Jimmy Carter signed by the heads of three major religious organizations: the National Council of Churches, the Synagogue Council of America, and the U.S. Catholic Conference. “We are rapidly moving into a new era of fundamental danger triggered by the rapid growth of genetic engineering,” they wrote. “Who shall determine how human good is best served when new life forms are being engineered?”13 These decisions should not be left to scientists, the trio argued. “There will always be those who believe it appropriate to ‘correct’ our mental and social structures by genetic means. This becomes more dangerous when the basic tools to do so are finally at hand. Those who would play God will be tempted as never before.

That was a fine story,” I told her, “one of the best that I’ve ever heard.” “I had to live it,” she replied, “and it is far better to hear such stories than to live them, I promise you, though it ended so happily.

there are studies showing that one oxytocin receptor gene variant is associated with extreme aggression in kids, as well as a callous, unemotional style that foreshadows adult psychopathy.54 Moreover, another variant is associated with social disconnection in kids and unstable adult relationships. But unfortunately these findings are uninterpretable because no one knows if these variants produce more, less, or the usual amount of oxytocin signaling.

He swore by all that he ever had loved and reverenced that he would try, try with all his might in the short time that might remain to him...he would forget himself, he would put his own pain and chagrin and disappointment, his own feeling of defeat and uselessness, his own craving for love and intellectual companionship in the background, and he would see if the more than six feet of bone and muscle that contained his being could do any small service that might come his way for God and his fellow man before he went. Maybe if he could accomplish some little thing, something that would ease the ache of even one heart that ached as his was aching at that minute, just maybe that knowledge would be the secret that he might carry in his breast that would set the stamp of an indelible smile on his face, so that even a child could discern the majesty of the impulse and he would not be ashamed when the end came.

For those who have never attended a science fiction convention, masquerades are features of most of the larger ones. Awards are presented for best costume, most beautiful costume, most humorous costume, most naked lady, and so on.

Remarkably, the fetal brain generates far more neurons than are found in the adult. Why? During late fetal development, there is a dramatic competition in much of the brain, with winning neurons being the ones that migrate to the correct location and maximize synaptic connections to other neurons. And neurons that don’t make the grade? They undergo “programmed cell death”—genes are activated that cause them to shrivel and die, their materials then recycled.

You wouldn’t understand, of course, but the bond between a mother and child, it’s . . . how best to describe it . . . unbreakable. The two of us are linked forever, you see—same blood in my veins that’s running through yours. You grew inside me, your teeth and your tongue and your cervix are all made from my cells, my genes. Who knows what little surprises I left growing inside there for you, which codes I set running? Breast cancer? Alzheimer’s? You’ll just have to wait and see. You were fermenting inside me for all those months, nice and cozy, Eleanor. However hard you try to walk away from that fact, you can’t, darling, you simply can’t. It isn’t possible to destroy a bond that strong.

Years later, I read that someone had found genetic components to good motherhood. The Mest and the Peg3 genes occur on chromosome 19, and, ironically, they only work if they’re inherited from the father. Imprinting like this usually occurs in evolution because of a genetic battle of the sexes; it’s in the best interests of the female to have more litters, but it’s in the best interests of the male to protect the child that’s already been born. The jury is still out on these

When it grew cold enough to shut the doors, and have fire at night, first thing after supper all of us helped clear the table, then we took our slates and books and learned our lessons for the next day, and then father lined us against the wall, all in a row from Laddie down, and he pronounced words—easy ones that divided into syllables nicely, for me, harder for May, and so up until I might sit down. For Laddie, May and Leon he used the geography, the Bible, Roland's history, the Christian Advocate, and the Agriculturist. My, but he had them so they could spell! After that, as memory tests, all of us recited our reading lesson for the next day, especially the poetry pieces. I knew most of them, from hearing the big folks repeat them so often and practise the proper way to read them. I could do "Rienzi's Address to the Romans," "Casablanca," "Gray's Elegy," or "Mark Antony's Speech," but best of all, I liked "Lines to a Water-fowl." When he was tired, if it were not bedtime yet, all of us, boys too, sewed rags for carpet and rugs. Laddie braided corn husks for the kitchen and outside door mats, and they were pretty, and "very useful too," like the dog that got his head patted in McGuffey's Second.

Perhaps we should rejoice that people’s emotions aren’t designed for the good of the group. Often the best way to benefit one’s group is to displace, subjugate, or annihilate the group next door. Ants in a colony are closely related, and each is a paragon of unselfishness. That’s why ants are one of the few kinds of animal that wage war and take slaves. When human leaders have manipulated or coerced people into submerging their interests into the group’s, the outcomes are some of the history’s worst atrocities.

Suppose a person harmed people two generations ago; are this person’s grandchildren obliged to help his victims’ grandchildren? Subjects viewed a biological grandchild as more obligated than one adopted into the family at birth; the biological relationship carried a taint. Moreover, subjects were more willing to jail two long-lost identical twins for a crime committed by one of them than to jail two unrelated but perfect look-alikes—the former, raised in different environments, share a moral taint because of their identical genes.

Another gene/environment interaction pertains to depression, a disease involving serotonin abnormalities.33 A gene called 5HTT codes for a transporter that removes serotonin from the synapse; having a particular 5HTT variant increases the risk of depression … but only when coupled with childhood trauma.fn23 What’s the effect of 5HTT variant on depression risk? It depends on childhood trauma exposure. What’s the effect of childhood trauma exposure on depression risk? It depends on 5HTT variant (plus loads of other genes, but you get the point).

How does this work? Rodents produce pheromonal odors with individual signatures, derived from genes called the major histocompatibility complex (MHC). This is a super variable gene cluster that produces unique proteins that form a signature for an individual. This was first studied by immunologists. What does the immune system do? It differentiates between you and invaders—“self” and “nonself”—and attacks the latter. All your cells carry your unique MHC-derived protein, and surveillance immune cells attack any cell lacking this protein password.

This has been a book about people trying to solve problems created by people trying to solve problems. In the course of reporting it, I spoke to engineers and genetic engineers, biologists and microbiologists, atmospheric scientists and atmospheric entrepreneurs. Without exception, they were enthusiastic about their work. But, as a rule, this enthusiasm was tempered by doubt. The electric fish barriers, the concrete crevasse, the fake cavern, the synthetic clouds- these were presented to me less in a spirit of techno-optimism than what might be called techno-fatalism. They weren't improvements on the originals; they were the best that anyone could come up with, given the circumstances... It's in this context that interventions like assisted evolution and gene drives and digging millions of trenches to bury billions of trees have to be assessed. Geoengineering may be 'entirely crazy and quite disconcerting', but if it could slow the melting of the Greenland ice sheet, or take some of 'the pain and suffering away', or help prevent no-longer-fully-natural ecosystems from collapsing, doesn't it have to be considered?

there is a hidden intelligence embedded in the female fertility cycle: an ancient knowledge that women can use to make the best decisions in their modern lives. Behind the everyday behavior that some interpret as simply “hormonal,” there is a biochemical process that has helped females—billions across thousands of species—choose mates, avoid rape, compete with female rivals, fight for resources, and produce offspring with fit genes and good prospects. To master these challenges, female brains evolved to conspire with their hormones rather than be corrupted by them.

Now consider a genome consisting of genes A and B, meaning three different transcription profiles—A is transcribed, B is transcribed, A and B are transcribed—requiring three different TFs (assuming you activate only one at a time). Three genes, seven transcription profiles: A, B, C, A + B, A + C, B + C, A + B + C. Seven different TFs. Four genes, fifteen profiles. Five genes, thirty-one profiles.fn7 As the number of genes in a genome increases, the number of possible expression profiles increases exponentially. As does the number of TFs needed to produce those profiles.

In other words, the weight of the evidence filtering down from the high brain-rooms of both the New York Times and the Washington Post seems to say we’re all fucked. Muskie is a bonehead who steals his best lines from old Nixon speeches. McGovern is doomed because everybody who knows him has so much respect for the man that they can’t bring themselves to degrade the poor bastard by making him run for President… John Lindsay is a dunce, Gene McCarthy is crazy, Humphrey is doomed and useless, Jackson should have stayed in bed… and, well, that just about wraps up the trip, right?

In fact, like other personality traits, personal happiness appears to be strongly influenced by our genes. Studies of identical and fraternal twins show that identical twins are significantly more likely to exhibit the same level of happiness than are fraternal twins or other siblings. Behavior geneticists have used these studies to estimate just how much genes matter, and their best guess is that long-term happiness depends 50 percent on a person’s genetic set point, 10 percent on their circumstances (e.g., where they live, how rich they are, how healthy they are), and 40 percent on what they choose to think and do.31

Let’s incorporate behavior. If someone has extensive frontocortical damage, how predictable is it that you’d note something odd about them, behaviorally, after a five-minute conversation? Something like 75 percent. Now let’s consider a broader range of behaviors. How predictable is it that this person with the frontal damage will do something horrifically violent at some point? Or that someone who was abused repeatedly as a child will become an abusive adult? That a soldier who went through a battle that killed his buddies will develop PTSD? That a person with the “montane vole” polygamous version of the vasopressin receptor gene promoter will have numerous failed marriages? That a person with a particular array of glutamate receptor subtypes throughout their cortex and hippocampus will have an IQ above 140? That someone raised with extensive childhood adversity and loss will have a major depressive disorder? All under 50 percent, often way under.

Elnora lifted the violin and began to play. She wore a school dress of green gingham, with the sleeves rolled to the elbows. She seemed a part of the setting all around her. Her head shone like a small dark sun, her face never had seemed so rose-flushed and fair. From the instant she drew the bow, her lips parted and her eyes fastened on something far away in the swamp, and never did she give more of that immpression of feeling for her notes and repeating something audible only to her. Ammon was to near to get the best effect. he arose and stepped back several yards, leaning against a large tree, looking and listening with all his soul. As he changed position he saw that Mrs. Comstock had followed them, and was standing on the trail, where she could not have helped hearing everything Elnora had said. So to Ammon before her and the mother watching on the trail, Elnora played the Song of the Limberlost. It seemed as if the swamp hushed all its other voices and spoke only through her dancing bow. The mother out on the trail had heard it all once before from the girl, many times from her father. To the man it was a revelation. He stood so stunned he forgot Mrs. Comstock. He tried to realize what a great city audience would say to that music, from such a player, with a like background, he could not imagine.

Of course genes are not directly visible to selection. Obviously they are selected by virtue of their phenotypic effects, and certainly they can only be said to have phenotypic effects in concert with hundreds of other genes. But it is the thesis of this book that we should not be trapped into assuming that those phenotypic effects are best regarded as being neatly wrapped up in discrete bodies (or other discrete vehicles). The doctrine of the extended phenotype is that the phenotypic effect of a gene (genetic replicator) is best seen as an effect upon the world at large, and only incidentally upon the individual organism—or any other vehicle—in which it happens to sit.

Evolution, or its driving engine natural selection, has no foresight. In every generation within every species, the individuals best equipped to survive and reproduce contribute more than their fair share of genes to the next generation. The consequence, blind as it is, is the nearest approach to foresight that nature permits. [...] It is always tinkering: here shrinking a bit, there expanding a bit, constantly adjusting, putting on and taking off, optimising immediate reproductive success. Survival in future centuries doesn’t enter into the calculation, for the good reason that it isn’t really a calculation at all. It all happens automatically, as some genes survive in the gene pool and others don’t.

If you don’t know I can’t tell you. Yes, I can; because I want to turn things around. Like, everybody all the time only does it for himself or something he sees being part of him only bigger, an empire or a church, like that. I’m doing it for ants, to set us loose.” The bearded man said, “You stoned?” “Sure I’m stoned. Ken, I’m stoned blind.” “You don’t look stoned, man.” “Trust me.

When the topic of food comes up in conversation with family, friends or casual acquaintances, it’s fascinating to hear the litany of rationalizations, knee-jerk defense mechanisms, self-limiting belief statements and general confusion or ignorance from otherwise intelligent folks when it comes to eating healthfully. But then again, Conventional Wisdom has often led even the best and brightest minds in nutritional science astray.

There are men—I have known a good many—who work all their lives for the same Fortune 500 company. They have families to support, and no skills that will permit them to leave and support their families by other means in another place. Their work is of little value, because few, if any, assignments of value come to them. They spend an amazing amount of time trying to find something useful to do. And, failing that, just trying to look busy.

Sex and love – I have only just realised how very different they are. Sex says spread your seed as widely as possible. Love says put all your eggs in one special basket. Sex says me, me, me: love says you, you, you. Sex says muscle in on all the best-looking genes you can find. Love says search for that one unforgettable face. Sex says move on, find someone new. Love says don’t let anyone or anything take her away. Sex, you see, is biology. But love is chemistry.

The world has been changing even faster as people, devices and information are increasingly connected to each other. Computational power is growing and quantum computing is quickly being realised. This will revolutionise artificial intelligence with exponentially faster speeds. It will advance encryption. Quantum computers will change everything, even human biology. There is already one technique to edit DNA precisely, called CRISPR. The basis of this genome-editing technology is a bacterial defence system. It can accurately target and edit stretches of genetic code. The best intention of genetic manipulation is that modifying genes would allow scientists to treat genetic causes of disease by correcting gene mutations. There are, however, less noble possibilities for manipulating DNA. How far we can go with genetic engineering will become an increasingly urgent question. We can’t see the possibilities of curing motor neurone diseases—like my ALS—without also glimpsing its dangers. Intelligence is characterised as the ability to adapt to change. Human intelligence is the result of generations of natural selection of those with the ability to adapt to changed circumstances. We must not fear change. We need to make it work to our advantage. We all have a role to play in making sure that we, and the next generation, have not just the opportunity but the determination to engage fully with the study of science at an early level, so that we can go on to fulfil our potential and create a better world for the whole human race. We need to take learning beyond a theoretical discussion of how AI should be and to make sure we plan for how it can be. We all have the potential to push the boundaries of what is accepted, or expected, and to think big. We stand on the threshold of a brave new world. It is an exciting, if precarious, place to be, and we are the pioneers. When we invented fire, we messed up repeatedly, then invented the fire extinguisher. With more powerful technologies such as nuclear weapons, synthetic biology and strong artificial intelligence, we should instead plan ahead and aim to get things right the first time, because it may be the only chance we will get. Our future is a race between the growing power of our technology and the wisdom with which we use it. Let’s make sure that wisdom wins.

The measuring rod, the unit of information, is something called a bit (for binary digit). It is an answer - either yes or no- to an unambiguous question... The information content of the human brain expressed in bits is probably comparable to the total number of connections among the neurons- about a hundred trillion, 10^14 bits. If written out in English, say, that information would fill some twenty million volumes, as many as in the world's largest libraries. The equivalent of twenty million books is inside the heads of every one of us... When our genes could not store all the information necessary for survival, we slowly invented them. But then the time came, perhaps ten thousand years ago, when we needed to stockpile enormous quantities of information outside our bodies. We are the only species on the planet, so far as we know, to have invented a communal memory stored neither in our genes nor in our brains. The warehouse of that memory is called the library... The great libraries of the world contain millions of volumes, the equivalent of about 10^14 bits of information in words, and perhaps 10^15 bits in pictures. This is ten thousand times more than in our brains. If I finish a book a week, I will only read a few thousand books in my lifetime, about a tenth of a percent of the contents of the greatest libraries of our time. The trick is to know which books to read... Books permit us to voyage through time, to tap the wisdom of our ancestors. The library connects us with the insights and knowledge, painfully extracted from Nature, of the greatest minds that ever were, with the best teachers, drawn from the entire planet and from all of our history, to instruct us without tiring, and to inspire us to make our own contribution to the collective knowledge of the human species. Public libraries depend on voluntary contributions. I think the health of our civilization, the depth of our awareness about the underpinnings of our culture and our concern for the future can all be tested by how well we support our libraries. p224-233

The time came. We had just bought a new car, small and cheap—but brand-new. I was returning to the Milford Conference (which I loved) with a story I felt certain was good. Ten or twenty miles from Milford, Pennsylvania, I topped a hill and saw yellow dots in the road. They were goldfinches, and as my new car drew nearer they flew up, a golden shower rising from the earth. There are no words to describe how happy I was at that moment, when I felt that a whole new life was opening before me. It was perfectly true. One was.

In the Paleolithic world in which our brains evolved, that’s not a bad way of making decisions. Gathering all evidence and mulling it over may be the best way to produce accurate answers, but a hunter-gatherer who consults statistics on lions before deciding whether to worry about the shadow moving in the grass isn’t likely to live long enough to bequeath his accuracy-maximizing genes to the next generation. Snap judgments are sometimes essential. As Daniel Kahneman puts it, “System 1 is designed to jump to conclusions from little evidence.”13

If you want to predict how happy someone is, or how long she will live (and if you are not allowed to ask about her genes or personality), you should find out about her social relationships. Having strong social relationships strengthens the immune system, extends life (more than does quitting smoking), speeds recovery from surgery, and reduces the risks of depression and anxiety disorders. It’s not just that extroverts are naturally happier and healthier; when introverts are forced to be more outgoing, they usually enjoy it and find that it boosts their mood. Even people who think they don’t want a lot of social contact still benefit from it. And it’s not just that “we all need somebody to lean on”; recent work on giving support shows that caring for others is often more beneficial than is receiving help. We need to interact and intertwine with others; we need the give and the take; we need to belong. An ideology of extreme personal freedom can be dangerous because it encourages people to leave homes, jobs, cities, and marriages in search of personal and professional fulfillment, thereby breaking the relationships that were probably their best hope for such fulfillment.

Mr. Mitchell should stop worrying and put Steph in charge. She will be good at this; she has the party planning gene in her family. I swear, they always have the entire familia over for every occasion. All her tias, tios, cousins, friends, ninas, and ninos go to her house for practically anything. Every day is a holiday at Casa Ayala. Anyway, we’re placed into committees, which totally sucks, because the fab four get split up. Keesha and I get selected for Activities, while Amy and Steph are slated for Rally committee. All the upperclassmen say these are the best committees, and we should feel lucky.

Why would we have evolved this way? The most probable answer is that an organism that responds quickly to fast-changing social environments will more likely survive them. That organism won’t have to wait around, as it were, for better genes to evolve on the species level. Immunologists discovered something similar twenty-five years ago: adapting to new pathogens the old-fashioned way—waiting for natural selection to favor genes that create resistance to specific pathogens—would happen too slowly to counter the rapidly changing pathogen environment. Instead, the immune system uses networks of genes that can respond quickly and flexibly to new threats.

The obvious question is, what are the “conditions to which presumably we are genetically adapted”? As it turns out, what Donaldson assumed in 1919 is still the conventional wisdom today: our genes were effectively shaped by the two and a half million years during which our ancestors lived as hunters and gatherers prior to the introduction of agriculture twelve thousand years ago. This is a period of time known as the Paleolithic era or, less technically, as the Stone Age, because it begins with the development of the first stone tools. It constitutes more than 99.5 percent of human history—more than a hundred thousand generations of humanity living as hunter-gatherers, compared with the six hundred succeeding generations of farmers or the ten generations that have lived in the industrial age. It’s not controversial to say that the agricultural period—the last .5 percent of the history of our species—has had little significant effect on our genetic makeup. What is significant is what we ate during the two and a half million years that preceded agriculture—the Paleolithic era. The question can never be answered definitively, because this era, after all, preceded human record-keeping. The best we can do is what nutritional anthropologists began doing in the mid-1980s—use modern-day hunter-gatherer societies as surrogates for our Stone Age ancestors.

My mother was the best and most beautiful woman who ever lived. She was clean, and good, and always helped "the poor and needy who cluster round your door," like it says in the poetry piece, and there never could have been a reason why God would want a woman to suffer herself, when she went flying on horseback even dark nights through rain or snow, to doctor other people's pain, and when she gave away things like she did—why, I've seen her take a big piece of meat from the barrel, and a sack of meal, and heaps of apples and potatoes to carry to Mandy Thomas—when she gave away food by the wagonload at a time, God couldn't have wanted her to be hungry, and yet she was that very minute almost crying for food;

Evolution, or its driving engine natural selection, has no foresight. In every generation within every species, the individuals best equipped to survive and reproduce contribute more than their fair share of genes to the next generation. The consequence, blind as it is, is the nearest approach to foresight that nature permits. [...] That’s the kind of thing natural selection does all the time. It is always tinkering: here shrinking a bit, there expanding a bit, constantly adjusting, putting on and taking off, optimising immediate reproductive success. Survival in future centuries doesn’t enter into the calculation, for the good reason that it isn’t really a calculation at all. It all happens automatically, as some genes survive in the gene pool and others don’t.

Among the most virulent of all such cultural parasite-equivalents is the religion-based denial of organic evolution. About one-half of Americans (46 percent in 2013, up from 44 percent in 1980), most of whom are evangelical Christians, together with a comparable fraction of Muslims worldwide, believe that no such process has ever occurred. As Creationists, they insist that God created humankind and the rest of life in one to several magical mega-strokes. Their minds are closed to the overwhelming mass of factual demonstrations of evolution, which is increasingly interlocked across every level of biological organization from molecules to ecosystem and the geography of biodiversity. They ignore, or more precisely they call it virtue to remain ignorant of, ongoing evolution observed in the field and even traced to the genes involved. Also looked past are new species created in the laboratory. To Creationists, evolution is at best just an unproven theory. To a few, it is an idea invented by Satan and transmitted through Darwin and later scientists in order to mislead humanity. When I was a small boy attending an evangelical church in Florida, I was taught that the secular agents of Satan are extremely bright and determined, but liars all, man and woman, and so no matter what I heard I must stick my fingers in my ears and hold fast to the true faith. We are all free in a democracy to believe whatever we wish, so why call any opinion such as Creationism a virulent cultural parasite-equivalent? Because it represents a triumph of blind religious faith over carefully tested fact. It is not a conception of reality forged by evidence and logical judgment. Instead, it is part of the price of admission to a religious tribe. Faith is the evidence given of a person’s submission to a particular god, and even then not to the deity directly but to other humans who claim to represent the god. The cost to society as a whole of the bowed head has been enormous. Evolution is a fundamental process of the Universe, not just in living organisms but everywhere, at every level. Its analysis is vital to biology, including medicine, microbiology, and agronomy. Furthermore psychology, anthropology, and even the history of religion itself make no sense without evolution as the key component followed through the passage of time. The explicit denial of evolution presented as a part of a “creation science” is an outright falsehood, the adult equivalent of plugging one’s ears, and a deficit to any society that chooses to acquiesce in this manner to a fundamentalist faith.

But despite the Secret Service–like behavior, and the regal nomenclature, there’s nothing hierarchical about the way an ant colony does its thinking. “Although queen is a term that reminds us of human political systems,” Gordon explains, “the queen is not an authority figure. She lays eggs and is fed and cared for by the workers. She does not decide which worker does what. In a harvester ant colony, many feet of intricate tunnels and chambers and thousands of ants separate the queen, surrounded by interior workers, from the ants working outside the nest and using only the chambers near the surface. It would be physically impossible for the queen to direct every worker’s decision about which task to perform and when.” The harvester ants that carry the queen off to her escape hatch do so not because they’ve been ordered to by their leader; they do it because the queen ant is responsible for giving birth to all the members of the colony, and so it’s in the colony’s best interest—and the colony’s gene pool—to keep the queen safe. Their genes instruct them to protect their mother, the same way their genes instruct them to forage for food. In other words, the matriarch doesn’t train her servants to protect her, evolution does. Popular culture trades in Stalinist ant stereotypes—witness the authoritarian colony regime in the animated film Antz—but in fact, colonies are the exact opposite of command economies. While they are capable of remarkably coordinated feats of task allocation, there are no Five-Year Plans in the ant kingdom. The colonies that Gordon studies display some of nature’s most mesmerizing decentralized behavior: intelligence and personality and learning that emerges from the bottom up.

Jack coughed slightly and offered his hand. “Hi, uh. I’m Jack.” Kim took it. “Jack what?” “Huh?” “Your last name, silly.” “Jackson.” She blinked at him. “Your name is Jack Jackson?” He blushed. “No, uh, my first name’s Rhett, but I hate it, so…” He gestured to the chair and she sat. Her dress rode up several inches, exposing pleasing long lines of creamy skin. “Well, Jack, what’s your field of study?” “Biological Engineering, Genetics, and Microbiology. Post-doc. I’m working on a research project at the institute.” “Really? Oh, uh, my apple martini’s getting a little low.” “I’ve got that, one second.” He scurried to the bar and bought her a fresh one. She sipped and managed to make it look not only seductive but graceful as well. “What do you want to do after you’re done with the project?” Kim continued. “Depends on what I find.” She sent him a simmering smile. “What are you looking for?” Immediately, Jack’s eyes lit up and his posture straightened. “I started the project with the intention of learning how to increase the reproduction of certain endangered species. I had interest in the idea of cloning, but it proved too difficult based on the research I compiled, so I went into animal genetics and cellular biology. It turns out the animals with the best potential to combine genes were reptiles because their ability to lay eggs was a smoother transition into combining the cells to create a new species, or one with a similar ancestry that could hopefully lead to rebuilding extinct animals via surrogate birth or in-vitro fertilization. We’re on the edge of breaking that code, and if we do, it would mean that we could engineer all kinds of life and reverse what damage we’ve done to the planet’s ecosystem.” Kim stared. “Right. Would you excuse me for a second?” She wiggled off back to her pack of friends by the bar. Judging by the sniggering and the disgusted glances he was getting, she wasn’t coming back. Jack sighed and finished off his beer, massaging his forehead. “Yes, brilliant move. You blinded her with science. Genius, Jack.” He ordered a second one and finished it before he felt smallish hands on his shoulders and a pair of soft lips on his cheek. He turned to find Kamala had returned, her smile unnaturally bright in the black lights glowing over the room. “So…how did it go with Kim?” He shot her a flat look. “You notice the chair is empty.” Kamala groaned. “You talked about the research project, didn’t you?” “No!” She glared at him. “…maybe…” “You’re so useless, Jack.” She paused and then tousled his hair a bit. “Cheer up. The night’s still young. I’m not giving up on you.” He smiled in spite of himself. “Yet.” Her brown eyes flashed. “Never.

The final misconception is that evolution is “just a theory.” I will boldly assume that readers who have gotten this far believe in evolution. Opponents inevitably bring up that irritating canard that evolution is unproven, because (following an unuseful convention in the field) it is a “theory” (like, say, germ theory). Evidence for the reality of evolution includes: Numerous examples where changing selective pressures have changed gene frequencies in populations within generations (e.g., bacteria evolving antibiotic resistance). Moreover, there are also examples (mostly insects, given their short generation times) of a species in the process of splitting into two. Voluminous fossil evidence of intermediate forms in numerous taxonomic lineages. Molecular evidence. We share ~98 percent of our genes with the other apes, ~96 percent with monkeys, ~75 percent with dogs, ~20 percent with fruit flies. This indicates that our last common ancestor with other apes lived more recently than our last common ancestor with monkeys, and so on. Geographic evidence. To use Richard Dawkins’s suggestion for dealing with a fundamentalist insisting that all species emerged in their current forms from Noah’s ark—how come all thirty-seven species of lemurs that made landfall on Mt. Ararat in the Armenian highlands hiked over to Madagascar, none dying and leaving fossils in transit? Unintelligent design—oddities explained only by evolution. Why do whales and dolphins have vestigial leg bones? Because they descend from a four-legged terrestrial mammal. Why should we have arrector pili muscles in our skin that produce thoroughly useless gooseflesh? Because of our recent speciation from other apes whose arrector pili muscles were attached to hair, and whose hair stands up during emotional arousal.

She held the moth to the light. It was nearer brown than yellow,and she remembered having seen some like it in the boxes that afternoon.It was not the one needed to complete the collection,but Elnora might want it,so Mrs. Comstock held on. Then the Almighty was kind,or nature was sufficient,as you look at it,for following the law of its being when disturbed,the moth again threw the spray by which some suppose it attracts its kind,and liberally sprinkled Mrs. Comstock's dress front and arms. From that instant,she became the best moth bait ever invented. Every Polyphemus in range hastened to her,and other fluttering creatures of night followed. The influx came her way. She snatched wildly here and there until she had one in each hand and no place to put them. She could see more coming,and her aching heart,swollen with the strain of long excitement,hurt pitifully.She prayed in broken exclamations that did not always sound reverent,but never was a human soul more intense earnest.

This may be a bad time,” he says, “but there’s something I want to say to you.” I tense immediately, afraid that he’s going to name some crime of mine that went unacknowledged, or a confession that’s eating away at him, or something equally difficult. His expression is unreadable. “I just want to thank you,” he says, his voice low. “A group of scientists told you that my genes were damaged, that there was something wrong with me--they showed you test results that proved it. And even I started to believe it.” He touches my face, his thumb skimming my cheekbone, and his eyes are on mine, intense and insistent. “You never believed it,” he says. “Not for a second. You always insisted that I was…I don’t know, whole.” I cover his hand with my own. “Well, you are.” “No one has ever told me that before,” he says softly. “It’s what you deserve to hear,” I say firmly, my eyes going cloudy with tears. “That you’re whole, that you’re worth loving, that you’re the best person I’ve ever known.” Just as the last word leaves my mouth, he kisses me.

IS CARDIO BEST BEFORE OR AFTER LIFTING? NEITHER! Doing cardio right before or after lifting can seriously hinder muscle and strength gains. Why? Researchers from RMIT University worked with well–trained athletes in 2009 and found that “combining resistance exercise and cardio in the same session may disrupt genes for anabolism.” In laymen’s terms, they found that combining endurance and resistance training sends “mixed signals” to the muscles37. Cardio before the resistance training suppressed anabolic hormones such as IGF–1 and MGF, and cardio after resistance training increased muscle tissue breakdown. Several other studies, such as those conducted by Children’s National Medical Center38, the Waikato Institute of Technology39, and the University of Jyvaskyla (Finland)40 , came to same conclusions: training for both endurance and strength simultaneously impairs your gains on both fronts. Training purely for strength or purely for endurance in a workout is far superior. Cardio before weightlifting also saps your energy and makes it much harder to train heavy, which in turn inhibits your muscle growth. So, how do you do it right?

Here’s how I’ve always pictured mitigated free will: There’s the brain—neurons, synapses, neurotransmitters, receptors, brainspecific transcription factors, epigenetic effects, gene transpositions during neurogenesis. Aspects of brain function can be influenced by someone’s prenatal environment, genes, and hormones, whether their parents were authoritative or their culture egalitarian, whether they witnessed violence in childhood, when they had breakfast. It’s the whole shebang, all of this book. And then, separate from that, in a concrete bunker tucked away in the brain, sits a little man (or woman, or agendered individual), a homunculus at a control panel. The homunculus is made of a mixture of nanochips, old vacuum tubes, crinkly ancient parchment, stalactites of your mother’s admonishing voice, streaks of brimstone, rivets made out of gumption. In other words, not squishy biological brain yuck. And the homunculus sits there controlling behavior. There are some things outside its purview—seizures blow the homunculus’s fuses, requiring it to reboot the system and check for damaged files. Same with alcohol, Alzheimer’s disease, a severed spinal cord, hypoglycemic shock. There are domains where the homunculus and that brain biology stuff have worked out a détente—for example, biology is usually automatically regulating your respiration, unless you must take a deep breath before singing an aria, in which case the homunculus briefly overrides the automatic pilot. But other than that, the homunculus makes decisions. Sure, it takes careful note of all the inputs and information from the brain, checks your hormone levels, skims the neurobiology journals, takes it all under advisement, and then, after reflecting and deliberating, decides what you do. A homunculus in your brain, but not of it, operating independently of the material rules of the universe that constitute modern science. That’s what mitigated free will is about. I see incredibly smart people recoil from this and attempt to argue against the extremity of this picture rather than accept its basic validity: “You’re setting up a straw homunculus, suggesting that I think that other than the likes of seizures or brain injuries, we are making all our decisions freely. No, no, my free will is much softer and lurks around the edges of biology, like when I freely decide which socks to wear.” But the frequency or significance with which free will exerts itself doesn’t matter. Even if 99.99 percent of your actions are biologically determined (in the broadest sense of this book), and it is only once a decade that you claim to have chosen out of “free will” to floss your teeth from left to right instead of the reverse, you’ve tacitly invoked a homunculus operating outside the rules of science. This is how most people accommodate the supposed coexistence of free will and biological influences on behavior. For them, nearly all discussions come down to figuring what our putative homunculus should and shouldn’t be expected to be capable of.

so often I get optimistic and explain the best method of learning to write to students. I don’t believe any of them has ever tried it, but I will explain it to you now. After all, you may be the exception. When I read about this method, it was attributed to Benjamin Franklin, who invented and discovered so much. Certainly I did not invent it. But I did it, and it worked. That is more than can be said for most creative writing classes. Find a very short story by a writer you admire. Read it over and over until you understand everything in it. Then read it over a lot more. Here’s the key part. You must do this. Put it away where you cannot get at it. You will have to find a way to do it that works for you. Mail the story to a friend and ask him to keep it for you, or whatever. I left the story I had studied in my desk on Friday. Having no weekend access to the building in which I worked, I could not get to it until Monday morning. When you cannot see it again, write it yourself. You know who the characters are. You know what happens. You write it. Make it as good as you can. Compare your story to the original, when you have access to the original again. Is your version longer? Shorter? Why? Read both versions out loud. There will be places where you had trouble. Now you can see how the author handled those problems. If you want to learn to write fiction, and are among those rare people willing to work at it, you might want to use the little story you have just finished as one of your models. It’s about the right length.     P

Sam’s the man who’s come to chop us up to bits. No wonder I kicked him out. No wonder I changed the locks. If he cannot stop death, what good is he? ‘Open the door. Please. I’m so tired,’ he says. I look at the night that absorbed my life. How am I supposed to know what’s love, what’s fear? ‘If you’re Sam who am I?’ ‘I know who you are.’ ‘You do?’ ‘Yeah.’ ‘Who?’ Don’t say wife, I think. Don’t say mother. I put my face to the glass, but it’s dark. I don’t reflect. Sam and I watch each other through the window of the kitchen door. He coughs some more. ‘I want to come home,’ he says. ‘I want us to be okay. That’s it. Simple. I want to come home and be a family.’ ‘But I am not simple.’ My body’s coursing with secret genes and hormones and proteins. My body made eyeballs and I have no idea how. There’s nothing simple about eyeballs. My body made food to feed those eyeballs. How? And how can I not know or understand the things that happen inside my body? That seems very dangerous. There’s nothing simple here. I’m ruled by elixirs and compounds. I am a chemistry project conducted by a wild child. I am potentially explosive. Maybe I love Sam because hormones say I need a man to kill the coyotes at night, to bring my babies meat. But I don’t want caveman love. I want love that lives outside the body. I want love that lives. ‘In what ways are you not simple?’ I think of the women I collected upstairs. They’re inside me. And they are only a small fraction of the catalog. I think of molds, of the sea, the biodiversity of plankton. I think of my dad when he was a boy, when he was a tree bud. ‘It’s complicated,’ I say, and then the things I don’t say yet. Words aren’t going to be the best way here. How to explain something that’s coming into existence? ‘I get that now.’ His shoulders tremble some. They jerk. He coughs. I have infected him. ‘Sam.’ We see each other through the glass. We witness each other. That’s something, to be seen by another human, to be seen over all the years. That’s something, too. Love plus time. Love that’s movable, invisible as a liquid or gas, love that finds a way in. Love that leaks. ‘Unlock the door,’ he says. ‘I don’t want to love you because I’m scared.’ ‘So you imagine bad things about me. You imagine me doing things I’ve never done to get rid of me. Kick me out so you won’t have to worry about me leaving?’ ‘Yeah,’ I say. ‘Right.’ And I’m glad he gets that. Sam cocks his head the same way a coyote might, a coyote who’s been temporarily confused by a question of biology versus mortality. What’s the difference between living and imagining? What’s the difference between love and security? Coyotes are not moral. ‘Unlock the door?’ he asks. This family is an experiment, the biggest I’ve ever been part of, an experiment called: How do you let someone in? ‘Unlock the door,’ he says again. ‘Please.’ I release the lock. I open the door. That’s the best definition of love. Sam comes inside. He turns to shut the door, then stops himself. He stares out into the darkness where he came from. What does he think is out there? What does he know? Or is he scared I’ll kick him out again? That is scary. ‘What if we just left the door open?’ he asks. ‘Open.’ And more, more things I don’ts say about the bodies of women. ‘Yeah.’ ‘What about skunks?’ I mean burglars, gangs, evil. We both peer out into the dark, looking for thees scary things. We watch a long while. The night does nothing. ‘We could let them in if they want in,’ he says, but seems uncertain still. ‘Really?’ He draws the door open wider and we leave it that way, looking out at what we can’t see. Unguarded, unafraid, love and loved. We keep the door open as if there are no doors, no walls, no skin, no houses, no difference between us and all the things we think of as the night.

We have looked at some of the things that a female might do if she has been deserted by her mate. But these all have the air of making the best of a bad job. Is there anything a female can do to reduce the extent to which her mate exploits her in the first place? She has a strong card in her hand. She can refuse to copulate. She is in demand, in a seller's market. This is because she brings the dowry of a large, nutritious egg. A male who successfully copulates gains a valuable food reserve for his offspring. The female is potentially in a position to drive a hard bargain before she copulates. Once she has copulated she has played her ace — her egg has been committed to the male. It is all very well to talk about driving hard bargains, but we know very well it is not really like that. Is there any realistic way in which something equivalent to driving a hard bargain could evolve by natural selection? I shall consider two main possibilities, called the domestic-bliss strategy, the he-man strategy. The simplest version of the domestic-bliss strategy is this. The female looks the males over, and tries to spot signs of fidelity and domesticity in advance. There is bound to be variation in the population of males in their predisposition to be faithful husbands. If females could recognize such qualities in advance, they could benefit themselves by choosing males possessing them. One way for a female to do this is to play hard to get for a long time, to be coy. Any male who is not patient enough to wait until the female eventually consents to copulate is not likely to be a good bet as a faithful husband. By insisting on a long engagement period, a female weeds out casual suitors, and only finally copulates with a male who has proved his qualities of fidelity and perseverance in advance. Feminine coyness is in fact very common among animals, and so are prolonged courtship or engagement periods. As we have already seen, a long engagement can also benefit a male where there is a danger of his being duped into caring for another male's child.