Gene Editing Embryos Quotes

Much of the attention paid to CRISPR these days involves its potential to make inheritable (germline) edits in humans that will be passed along to all the cells of all of our future descendants and have the potential to alter our species. These edits are done in reproductive cells or early-stage embryos. This is what occurred with the CRISPR baby twins in China in 2018, and it is the controversial topic that I will discuss later in this book.

It’s harder to persuade mammalian cells to incorporate the new genes, for a start. And if you want living organisms such as live mice, rather than just mouse cells in the lab, you need to inject DNA into fertilised mouse eggs, implant these eggs into female mice, and hope the tiny embryos develop and grow OK.

only a remote possibility in the United States, since existing reproductive procedures such as IVF and PGD, which routinely cost tens of thousands of dollars, are seldom covered by health insurance. But in places like France, Israel, and Sweden, countries whose national health plans cover assisted reproduction, it’s possible that simple economics will incentivize governments to make gene editing available to patients who need it. After all, providing lifelong treatment to a single person with a genetic disease could be much more expensive than prophylactic intervention in the embryo using gene editing.

make sure that they wouldn’t be able to contract the HIV infection, even though, as the AIDS researcher Anthony Fauci quickly pointed out, “there are so many ways to adequately, efficiently, and definitively protect yourself against HIV that the thought of editing the genes of an embryo to get to an effect that you could easily do in so many other ways in my mind is unethical.