Famous Genetics Quotes

It is a well-known established fact throughout the many-dimensional worlds of the multiverse that most really great discoveries are owed to one brief moment of inspiration. There's a lot of spadework first, of course, but what clinches the whole thing is the sight of, say, a falling apple or a boiling kettle or the water slipping over the edge of the bath. Something goes click inside the observer's head and then everything falls into place. The shape of DNA, it is popularly said, owes its discovery to the chance sight of a spiral staircase when the scientist‘s mind was just at the right receptive temperature. Had he used the elevator, the whole science of genetics might have been a good deal different. This is thought of as somehow wonderful. It isn't. It is tragic. Little particles of inspiration sleet through the universe all the time traveling through the densest matter in the same way that a neutrino passes through a candyfloss haystack, and most of them miss. Even worse, most of the ones that hit the exact cerebral target, hit the wrong one. For example, the weird dream about a lead doughnut on a mile-high gantry, which in the right mind would have been the catalyst for the invention of repressed-gravitational electricity generation (a cheap and inexhaustible and totally non-polluting form of power which the world in question had been seeking for centuries, and for the lack of which it was plunged into a terrible and pointless war) was in fact had by a small and bewildered duck. By another stroke of bad luck, the sight of a herd of wild horses galloping through a field of wild hyacinths would have led a struggling composer to write the famous Flying God Suite, bringing succor and balm to the souls of millions, had he not been at home in bed with shingles. The inspiration thereby fell to a nearby frog, who was not in much of a position to make a startling contributing to the field of tone poetry. Many civilizations have recognized this shocking waste and tried various methods to prevent it, most of them involving enjoyable but illegal attempts to tune the mind into the right wavelength by the use of exotic herbage or yeast products. It never works properly.

Beauty is in the streets,” they say in Paris. We travelers know our favorites, Parisians know theirs. Jean Genet liked to stand with his friend Giacometti at the foot of rue Oberkampf, taking in its long uphill from the Marais to Belleville. Simone Weil loved walking the quays of Île Saint-Louis in her native river city. The scruffy streets of the ninth were François Truffaut’s muse and mother. As cities evolve and erupt, streets change; Parisians come and go. But the beauty remains.

Gene patents are the point of greatest concern in the debate over ownership of human biological materials, and how that ownership might interfere with science. As of 2005—the most recent year figures were available—the U.S. government had issued patents relating to the use of about 20 percent of known human genes, including genes for Alzheimer’s, asthma, colon cancer, and, most famously, breast cancer. This means pharmaceutical companies, scientists, and universities control what research can be done on those genes, and how much resulting therapies and diagnostic tests will cost. And some enforce their patents aggressively: Myriad Genetics, which holds the patents on the BRCA1 and BRCA2 genes responsible for most cases of hereditary breast and ovarian cancer, charges $3,000 to test for the genes. Myriad has been accused of creating a monopoly, since no one else can offer the test, and researchers can’t develop cheaper tests or new therapies without getting permission from Myriad and paying steep licensing fees. Scientists who’ve gone ahead with research involving the breast-cancer genes without Myriad’s permission have found themselves on the receiving end of cease-and-desist letters and threats of litigation.

By the time Eisenhower gave his famous Military-Industrial Complex speech, we knew alien experiments on sleeping victims were increasing annually.  Six months before Kennedy was assassinated, we knew the alien goal was to genetically alter the human race for their own purposes and that one of the side effects would be to increase the number of people born with autism by five hundred to a thousand times.

And by the early 1970s our little parable of Sam and Sweetie is exactly what happened to the North American Golden Retriever. One field-trial dog, Holway Barty, and two show dogs, Misty Morn’s Sunset and Cummings’ Gold-Rush Charlie, won dozens of blue ribbons between them. They were not only gorgeous champions; they had wonderful personalities. Consequently, hundreds of people wanted these dogs’ genes to come into their lines, and over many matings during the 1970s the genes of these three dogs were flung far and wide throughout the North American Golden Retriever population, until by 2010 Misty Morn’s Sunset alone had 95,539 registered descendants, his number of unregistered ones unknown. Today hundreds of thousands of North American Golden Retrievers are descended from these three champions and have received both their sweet dispositions and their hidden time bombs. Unfortunately for these Golden Retrievers, and for the people who love them, one of these time bombs happens to be cancer. To be fair, a so-called cancer gene cannot be traced directly to a few famous sires, but using these sires so often increases the chance of recessive genes meeting—for good and for ill. Today, in the United States, 61.4 percent of Golden Retrievers die of cancer, according to a survey conducted by the Golden Retriever Club of America and the Purdue School of Veterinary Medicine. In Great Britain, a Kennel Club survey found almost exactly the same result, if we consider that those British dogs—loosely diagnosed as dying of “old age” and “cardiac conditions” and never having been autopsied—might really be dying of a variety of cancers, including hemangiosarcoma, a cancer of the lining of the blood vessels and the spleen. This sad history of the Golden Retriever’s narrowing gene pool has played out across dozens of other breeds and is one of the reasons that so many of our dogs spend a lot more time in veterinarians’ offices than they should and die sooner than they might. In genetic terms, it comes down to the ever-increasing chance that both copies of any given gene are derived from the same ancestor, a probability expressed by a number called the coefficient of inbreeding. Discovered in 1922 by the American geneticist Sewall Wright, the coefficient of inbreeding ranges from 0 to 100 percent and rises as animals become more inbred.

Near the exit to the blue patio, DeCoverley Pox and Joaquin Stick stand by a concrete scale model of the Jungfrau, ... socking the slopes of the famous mountain with red rubber hot-water bags full of ice cubes, the idea being to pulverize the ice for Pirate's banana frappes. With their nights' growths of beard, matted hair, bloodshot eyes, miasmata of foul breath, DeCoverley and Joaquin are wasted gods urging on a tardy glacier. Elsewhere in the maisonette, other drinking companions disentangle from blankets (one spilling wind from his, dreaming of a parachute), piss into bathroom sinks, look at themselves with dismay in concave shaving mirrors, slab water with no clear plan in mind onto heads of thinning hair, struggle into Sam Brownes, dub shoes against rain later in the day with hand muscles already weary of it, sing snatches of popular songs whose tunes they don't always know, lie, believing themselves warmed, in what patches of the new sunlight come between the mullions, begin tentatively to talk shop as a way of easing into whatever it is they'll have to be doing in less than an hour, lather necks and faces, yawn, pick their noses, search cabinets or bookcases for the hair of the dog that not without provocation and much prior conditioning bit them last night. Now there grows among all the rooms, replacing the night's old smoke, alcohol and sweat, the fragile, musaceous odor of Breakfast:flowery, permeating, surprising, more than the color of winter sunlight, taking over not so much through any brute pungency or volume as by the high intricacy to the weaving of its molecules, sharing the conjuror's secret by which-- though it is not often Death is told so clearly to fuck off--- the genetic chains prove labyrinthine enough to preserve some human face down ten or twenty generations. . . so the same assertion-through-structure allows this war morning's banana fragrance to meander, repossess, prevail. Is there any reason not to open every window, and let the kind scent blanket all Chelsea? As a spell, against falling objects. . . .

JULIAN HUXLEY’S “EUGENICS MANIFESTO”: “Eugenics Manifesto” was the name given to an article supporting eugenics. The document, which appeared in Nature, September 16, 1939, was a joint statement issued by America’s and Britain’s most prominent biologists, and was widely referred to as the “Eugenics Manifesto.” The manifesto was a response to a request from Science Service, of Washington, D.C. for a reply to the question “How could the world’s population be improved most effectively genetically?” Two of the main signatories and authors were Hermann J. Muller and Julian Huxley. Julian Huxley, as this book documents, was the founding director of UNESCO from the famous Huxley family. Muller was an American geneticist, educator and Nobel laureate best known for his work on the physiological and genetic effects of radiation. Put into the context of the timeline, this document was published 15 years after “Mein Kampf” and a year after the highly publicized violence of Kristallnacht. In other words, there is no way either Muller or Huxley were unaware at the moment of publication of the historical implications of eugenic agendas.

Many kinds of animal behavior can be explained by genetic similarity theory. Animals have a preference for close kin, and study after study has shown that they have a remarkable ability to tell kin from strangers. Frogs lay eggs in bunches, but they can be separated and left to hatch individually. When tadpoles are then put into a tank, brothers and sisters somehow recognize each other and cluster together rather than mix with tadpoles from different mothers. Female Belding’s ground squirrels may mate with more than one male before they give birth, so a litter can be a mix of full siblings and half siblings. Like tadpoles, they can tell each other apart. Full siblings cooperate more with each other than with half-siblings, fight less, and are less likely to run each other out of the territory when they grow up. Even bees know who their relatives are. In one experiment, bees were bred for 14 different degrees of relatedness—sisters, cousins, second cousins, etc.—to bees in a particular hive. When the bees were then released near the hive, guard bees had to decide which ones to let in. They distinguished between degrees of kinship with almost perfect accuracy, letting in the closest relatives and chasing away more distant kin. The correlation between relatedness and likelihood of being admitted was a remarkable 0.93. Ants are famous for cooperation and willingness to sacrifice for the colony. This is due to a quirk in ant reproduction that means worker ants are 70 percent genetically identical to each other. But even among ants, there can be greater or less genetic diversity, and the most closely related groups of ants appear to cooperate best. Linepithema humile is a tiny ant that originated in Argentina but migrated to the United States. Many ants died during the trip, and the species lost much of its genetic diversity. This made the northern branch of Linepithema humile more cooperative than the one left in Argentina, where different colonies quarrel and compete with each other. This new level of cooperation has helped the invaders link nests into supercolonies and overwhelm local species of ants. American entomologists want to protect American ants by introducing genetic diversity so as to make the newcomers more quarrelsome. Even plants cooperate with close kin and compete with strangers. Normally, when two plants are put in the same pot, they grow bigger root systems, trying to crowd each other out and get the most nutrients. A wild flower called the Sea Rocket, which grows on beaches, does not do that if the two plants come from the same “mother” plant. They recognize each others’ root secretions and avoid wasteful competition.

Take the famous slogan on the atheist bus in London … “There’s probably no God. Now stop worrying and enjoy your life.” … The word that offends against realism here is “enjoy.” I’m sorry—enjoy your life? Enjoy your life? I’m not making some kind of neo-puritan objection to enjoyment. Enjoyment is lovely. Enjoyment is great. The more enjoyment the better. But enjoyment is one emotion … Only sometimes, when you’re being lucky, will you stand in a relationship to what’s happening to you where you’ll gaze at it with warm, approving satisfaction. The rest of the time, you’ll be busy feeling hope, boredom, curiosity, anxiety, irritation, fear, joy, bewilderment, hate, tenderness, despair, relief, exhaustion … This really is a bizarre category error. But not necessarily an innocent one … The implication of the bus slogan is that enjoyment would be your natural state if you weren’t being “worried” by us believer … Take away the malignant threat of God-talk, and you would revert to continuous pleasure, under cloudless skies. What’s so wrong with this, apart from it being total bollocks? … Suppose, as the atheist bus goes by, that you are the fifty-something woman with the Tesco bags, trudging home to find out whether your dementing lover has smeared the walls of the flat with her own shit again. Yesterday when she did it, you hit her, and she mewled till her face was a mess of tears and mucus which you also had to clean up. The only thing that would ease the weight on your heart would be to tell the funniest, sharpest-tongued person you know about it: but that person no longer inhabits the creature who will meet you when you unlock the door. Respite care would help, but nothing will restore your sweetheart, your true love, your darling, your joy. Or suppose you’re that boy in the wheelchair, the one with the spasming corkscrew limbs and the funny-looking head. You’ve never been able to talk, but one of your hands has been enough under your control to tap out messages. Now the electrical storm in your nervous system is spreading there too, and your fingers tap more errors than readable words. Soon your narrow channel to the world will close altogether, and you’ll be left all alone in the hulk of your body. Research into the genetics of your disease may abolish it altogether in later generations, but it won’t rescue you. Or suppose you’re that skanky-looking woman in the doorway, the one with the rat’s nest of dreadlocks. Two days ago you skedaddled from rehab. The first couple of hits were great: your tolerance had gone right down, over two weeks of abstinence and square meals, and the rush of bliss was the way it used to be when you began. But now you’re back in the grind, and the news is trickling through you that you’ve fucked up big time. Always before you’ve had this story you tell yourself about getting clean, but now you see it isn’t true, now you know you haven’t the strength. Social services will be keeping your little boy. And in about half an hour you’ll be giving someone a blowjob for a fiver behind the bus station. Better drugs policy might help, but it won’t ease the need, and the shame over the need, and the need to wipe away the shame. So when the atheist bus comes by, and tells you that there’s probably no God so you should stop worrying and enjoy your life, the slogan is not just bitterly inappropriate in mood. What it means, if it’s true, is that anyone who isn’t enjoying themselves is entirely on their own. The three of you are, for instance; you’re all three locked in your unshareable situations, banged up for good in cells no other human being can enter. What the atheist bus says is: there’s no help coming … But let’s be clear about the emotional logic of the bus’s message. It amounts to a denial of hope or consolation, on any but the most chirpy, squeaky, bubble-gummy reading of the human situation. St Augustine called this kind of thing “cruel optimism” fifteen hundred years ago, and it’s still cruel.

This, in turn, has given us a “unified theory of aging” that brings the various strands of research into a single, coherent tapestry. Scientists now know what aging is. It is the accumulation of errors at the genetic and cellular level. These errors can build up in various ways. For example, metabolism creates free radicals and oxidation, which damage the delicate molecular machinery of our cells, causing them to age; errors can build up in the form of “junk” molecular debris accumulating inside and outside the cells. The buildup of these genetic errors is a by-product of the second law of thermodynamics: total entropy (that is, chaos) always increases. This is why rusting, rotting, decaying, etc., are universal features of life. The second law is inescapable. Everything, from the flowers in the field to our bodies and even the universe itself, is doomed to wither and die. But there is a small but important loophole in the second law that states total entropy always increases. This means that you can actually reduce entropy in one place and reverse aging, as long as you increase entropy somewhere else. So it’s possible to get younger, at the expense of wreaking havoc elsewhere. (This was alluded to in Oscar Wilde’s famous novel The Picture of Dorian Gray. Mr. Gray was mysteriously eternally young. But his secret was the painting of himself that aged horribly. So the total amount of aging still increased.) The principle of entropy can also be seen by looking behind a refrigerator. Inside the refrigerator, entropy decreases as the temperature drops. But to lower the entropy, you have to have a motor, which increases the heat generated behind the refrigerator, increasing the entropy outside the machine. That is why refrigerators are always hot in the back. As Nobel laureate Richard Feynman once said, “There is nothing in biology yet found that indicates the inevitability of death. This suggests to me that it is not at all inevitable and that it is only a matter of time before biologists discover what it is that is causing us the trouble and that this terrible universal disease or temporariness of the human’s body will be cured.

Beyoncé and Rihanna were pop stars. Pop stars were musical performers whose celebrity had exploded to the point where they could be identified by single words. You could say BEYONCÉ or RIHANNA to almost anyone anywhere in the industrialized world and it would conjure a vague neurological image of either Beyoncé or Rihanna. Their songs were about the same six subjects of all songs by all pop stars: love, celebrity, fucking, heartbreak, money and buying ugly shit. It was the Twenty-First Century. It was the Internet. Fame was everything. Traditional money had been debased by mass production. Traditional money had ceased to be about an exchange of humiliation for food and shelter. Traditional money had become the equivalent of a fantasy world in which different hunks of vampiric plastic made emphatic arguments about why they should cross the threshold of your home. There was nothing left to buy. Fame was everything because traditional money had failed. Fame was everything because fame was the world’s last valid currency. Beyoncé and Rihanna were part of a popular entertainment industry which deluged people with images of grotesque success. The unspoken ideology of popular entertainment was that its customers could end up as famous as the performers. They only needed to try hard enough and believe in their dreams. Like all pop stars, Beyoncé and Rihanna existed off the illusion that their fame was a shared experience with their fans. Their fans weren’t consumers. Their fans were fellow travelers on a journey through life. In 2013, this connection between the famous and their fans was fostered on Twitter. Beyoncé and Rihanna were tweeting. Their millions of fans were tweeting back. They too could achieve their dreams. Of course, neither Beyoncé nor Rihanna used Twitter. They had assistants and handlers who packaged their tweets for maximum profit and exposure. Fame could purchase the illusion of being an Internet user without the purchaser ever touching a mobile phone or a computer. That was a difference between the rich and the poor. The poor were doomed to the Internet, which was a wonderful resource for watching shitty television, experiencing angst about other people’s salaries, and casting doubt on key tenets of Mormonism and Scientology. If Beyoncé or Rihanna were asked about how to be like them and gave an honest answer, it would have sounded like this: “You can’t. You won’t. You are nothing like me. I am a powerful mixture of untamed ambition, early childhood trauma and genetic mystery. I am a portal in the vacuum of space. The formula for my creation is impossible to replicate. The One True God made me and will never make the like again. You are nothing like me.

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Reintroducing history into evolutionary thinking has already begun at other biological scales. The cell, once an emblem of replicable units, turns out to be the historical product of symbiosis among free- living bacteria. Even DNA turns out to have more history in its amino- acid sequences than once thought. Human DNA is part virus; viral encoun- ters mark historical moments in making us human. Genome research has taken up the challenge of identifying encounter in the making of DNA. Population science cannot avoid history for much longer. Fungi are ideal guides. Fungi have always been recalcitrant to the iron cage of self- replication. Like bacteria, some are given to exchanging genes in nonreproductive encounters (“horizontal gene transfer”); many also seem averse to keeping their genetic material sorted out as “individ- uals” and “species,” not to speak of “populations.” When researchers studied the fruiting bodies of what they thought of as a species, the ex- pensive Tibetan “caterpillar fungus,” they found many species entan- gled together. When they looked into the filaments of Armillaria root rot, they found genetic mosaics that confused the identification of an individual. Meanwhile, fungi are famous for their symbiotic attach- ments. Lichen are fungi living together with algae and cyanobacteria. I have been discussing fungal collaborations with plants, but fungi live with animals as well. For example, Macrotermes termites digest their food only through the help of fungi. The termites chew up wood, but they cannot digest it. Instead, they build “fungus gardens” in which the chewed- up wood is digested by Termitomyces fungi, producing edible nutrients. Researcher Scott Turner points out that, while you might say that the termites farm the fungus, you could equally say that the fungus farms the termites. Termitomyces uses the environment of the termite mound to outcompete other fungi; meanwhile, the fungus regulates the mound, keeping it open, by throwing up mushrooms annually, cre- ating a colony- saving disturbance in termite mound- building.

Consider these facts: the source of much of the world’s food – seeds – is mostly in the control of just four corporations; half of all the world’s cheeses are produced with bacteria or enzymes manufactured by a single company; one in four beers drunk around the world is the product of one brewer; from the USA to China, most global pork production is based around the genetics of a single breed of pig; and, perhaps most famously, although there are more than 1,500 different varieties of banana, global trade is dominated by just one, the Cavendish, a cloned fruit grown in monocultures so vast their scale can only be comprehended from the view of an aeroplane or by satellite.

In the same way that Firestone’s embrace of scientific and technological progress as manifest destiny tips its hat to Marx and Engels, so also it resembles (perhaps even more closely) the Marxist-inspired biofuturism of the interwar period, particularly in Britain, in the work of writers such as H. G. Wells, J. B. S. Haldane, J. D. Bernal, Julian Huxley, Conrad Waddington, and their contemporaries (including Gregory Bateson and Joseph Needham, the latter of whose embryological interests led to his enduring fascination with the history of technology in China). Interestingly, it is also in these early twentieth century writings that ideas about artificial reproduction, cybernation, space travel, genetic modification, and ectogenesis abound. As cultural theorist Susan Squier has demonstrated, debates about ectogenesis were crucial to both the scientific ambitions and futuristic narratives of many of the United Kingdom’s most eminent biologists from the 1920s and the 1930s onward. As John Burdon Sanderson (“Jack”) Haldane speculated in his famous 1923 paper “Daedalus, or Science and the Future” (originally read to the Heretics society in Cambridge) ectogenesis could provide a more efficient and rational basis for human reproduction in the future: [W]e can take an ovary from a woman, and keep it growing in a suitable fluid for as long as twenty years, producing a fresh ovum each month, of which 90 per cent can be fertilized, and the embryos grown successfully for nine months, and then brought out into the air.

In life’s journey, we often stumble upon remarkable souls—strangers who, with their extraordinary warmth and wisdom, make us feel as though we’ve known them for a lifetime. They teach us that family isn’t solely about genetics but about the profound influence of shared inspiration and genuine connection.

Another example is diabetes mellitus, a disease characterized by excess blood sugar due to insufficient insulin production. Over time, it can cause damage to blood vessels, kidneys, and nerves and lead to blindness. Type 1 diabetes, also known as juvenile-onset or insulin-dependent diabetes, is typically caused by autoimmune damage to the pancreas. Type 2 diabetes, a less serious disease, is linked to genetic and dietary factors. Some animal studies have indicated that CBD can reduce the incidence of diabetes, lower inflammatory proteins in the blood, and protect against retinal degeneration that leads to blindness [Armentano53]. As we have seen, patients have also found marijuana effective in treating the pain of diabetic neuropathy.   A famous example is Myron Mower, a gravely ill diabetic who grew his own marijuana under California’s medical marijuana law, Prop. 215, to help relieve severe nausea, appetite loss, and pain. Mower was arrested and charged with illegal cultivation after being interrogated by police in his hospital bed. In a landmark ruling, People v. Mower (2002), the California Supreme Court overturned his conviction, affirming that Prop. 215 gave him the same legal right to use marijuana as other prescription drugs.   While marijuana clearly provides symptomatic relief to many diabetics with appetite loss and neuropathy, scientific studies have yet to show whether it can also halt disease progression.

Again starting with an unusual Y-chromosome, they noticed its occurrence in a related set of surnames that were linked to branches of the Ui Neill, the clan that had held the High Kingship at Tara, and had expelled the Dál Riata to Argyll. The Ui Neill equivalent of Somerled was Niall Noigiallach, better known as Niall of the Nine Hostages, who lived in the second half of the fourth century AD. This was a time when the Romans were beginning to withdraw from mainland Britain. According to legend, Niall raided and harassed western Britain and specialized in capturing and then ransoming high-ranking hostages, hence his soubriquet. His most famous captive was one Succat, who went on to become St Patrick. Niall’s military exploits carried him over the sea to Scotland, where he fought the Picts who were trying to retake the recent Irish colonies of Dalriada. It was during a raid even further afield, in France, that an arrow from the bow of an Irish rival killed Niall on the banks of the River Loire in AD 405. Niall was succeeded in the High Kingship by his nephew, Dathi, his father’s brother’s son. This was typical of the Gaelic tradition of derbhfine, the rules of inheritance that chose the new king from among the direct male relatives of the old. This served to ensure the patrilineal inheritance of the High Kingship itself

Bill Wilson would never have another drink. For the next thirty-six years, until he died of emphysema in 1971, he would devote himself to founding, building, and spreading Alcoholics Anonymous, until it became the largest, most well-known and successful habit-changing organization in the world. An estimated 2.1 million people seek help from AA each year, and as many as 10 million alcoholics may have achieved sobriety through the group.3.12,3.13 AA doesn’t work for everyone—success rates are difficult to measure, because of participants’ anonymity—but millions credit the program with saving their lives. AA’s foundational credo, the famous twelve steps, have become cultural lodestones incorporated into treatment programs for overeating, gambling, debt, sex, drugs, hoarding, self-mutilation, smoking, video game addictions, emotional dependency, and dozens of other destructive behaviors. The group’s techniques offer, in many respects, one of the most powerful formulas for change. All of which is somewhat unexpected, because AA has almost no grounding in science or most accepted therapeutic methods. Alcoholism, of course, is more than a habit. It’s a physical addiction with psychological and perhaps genetic roots. What’s interesting about AA, however, is that the program doesn’t directly attack many of the psychiatric or biochemical issues that researchers say are often at the core of why alcoholics drink.3.14 In fact, AA’s methods seem to sidestep scientific and medical findings altogether, as well as the types of intervention many psychiatrists say alcoholics really need.1 What AA provides instead is a method for attacking the habits that surround alcohol use.3.15 AA, in essence, is a giant machine for changing habit loops. And though the habits associated with alcoholism are extreme, the lessons AA provides demonstrate how almost any habit—even the most obstinate—can be changed.

It is no accident that the man who famously observed that power is the greatest aphrodisiac was not, by a long shot, good looking. Often (in what we might call the Kissinger effect), the men with the greatest access to resources and status lack the genetic wealth signified by physical attractiveness.

At Falkland Palace, Andrew Melville famously reminded James VI in 1596 that: [t]hair is twa Kings and twa Kingdomes in Scotland. Thair is Christ Jesus the King, and His kingdom, the Kirk, whase subject King James the Saxt is, and of whase kingdome nocht a king, not a lord, not a heid, but a member.

MacArthur was ordered to return home, relieved of duty. Afterward, MacArthur famously addressed the Congress, waying, “There is no substitute for victory!

One important reason that philosophers should take Nietzsche seriously is because he seems to have gotten, at least in broad contours, many points about human moral psychology right. Consider: (1) Nietzsche holds that heritable type-facts are central determinants of personality and morally significant behaviors, a claim well supported by extensive empirical findings in behavioral genetics. (2) Nietzsche claims that consciousness is a “surface” and that “the greatest part of conscious thought must still be attributed to [non-conscious] instinctive activity,” theses overwhelmingly vindicated by recent work by psychologists on the role of the unconscious (e.g., Wilson 2002) and by philosophers who have produced synthetic meta-analyses of work on consciousness in psychology and neuroscience (e.g., Rosenthal 2008). (3) Nietzsche claims that moral judgments are post-hoc rationalizations of feelings that have an antecedent source, and thus are not the outcome of rational reflection or discursiveness, a conclusion in sync with the findings of the ascendent “social intuitionism” in the empirical moral psychology of Jonathan Haidt (2001) and others. (4) Nietzsche argues that free will is an “illusion,” that our conscious experience of willing is itself the causal product of non-conscious forces, a view recently defended by the psychologist Daniel Wegner (2002), who, in turn, synthesiyes a large body of empirical literature, including the famous neurophysical data about “willing” collected by Benjamin Libet.

You know, the famous geneticist. He pioneered genetically engineered offspring. Told my parents I would be special.

In 1974, San Francisco newspaper heiress Patty Hearst was kidnapped by a radical group called the Symbionese Liberation Army, whose goals included “death to the fascist insect that preys upon the life of the people.” After being kept in a closet for a while, she came to identify with her new peer group. Before long, she was enthusiastically helping them generate income, at one point brandishing a machine gun during a bank robbery. When left alone, with an opportunity to escape, she didn’t take it. She later described the experience: “I had virtually no free will until I was separated from them for about two weeks. And then it suddenly, you know, slowly began to dawn that they just weren’t there anymore. I could actually think my own thoughts.” Hearst didn’t just accept her captors’ “subjective” beliefs, such as ideology; she bought into their views about how the physical world works. One of her captors “didn’t want me thinking about rescue because he thought that brain waves could be read or that, you know, they’d get a psychic in to find me. And I was even afraid of that.” Hearst’s condition of coerced credulity is called the Stockholm syndrome, after a kidnapping in Sweden. But the term “syndrome” may be misleading in its suggestion of abnormality. Hearst’s response to her circumstances was probably an example of human nature functioning properly; we seem to be “designed” by natural selection to be brainwashed. Some people find this prospect a shocking affront to human autonomy, but they tend not to be evolutionary psychologists. In Darwinian terms, it makes sense that our species could contain genes encouraging blind credulity in at least some situations. If you are surrounded by a small group of people on whom your survival depends, rejecting the beliefs that are most important to them will not help you live long enough to get your genes into the next generation. Confinement with a small group of people may sound so rare that natural selection would have little chance to take account of it, but it is in a sense the natural human condition. Humans evolved in small groups—twenty, forty, sixty people—from which emigration was often not a viable option. Survival depended on social support: sharing food, sticking together during fights, and so on. To alienate your peers by stubbornly contesting their heartfelt beliefs would have lowered your chances of genetic proliferation. Maybe that explains why you don’t have to lock somebody in a closet to get a bit of the Stockholm syndrome. Religious cults just offer aimless teenagers a free bus ride to a free meal, and after the recruits have been surrounded by believers for a few days, they tend to warm up to the beliefs. And there doesn’t have to be some powerful authority figure pushing the beliefs. In one famous social psychology experiment, subjects opined that two lines of manifestly different lengths were the same length, once a few of their “peers” (who were in fact confederates) voiced that opinion.

The mostly white medical establishment in the U.S., meanwhile, tended to focus on so-called “race susceptibility,” the idea that something inherent in the genetics of Black people caused tuberculosis—a kind of spes phthisica for the infectious age. Some white doctors even argued that the “susceptibility” was caused by the end of slavery in the U.S. In his famous 1896 essay “The Effects of Emancipation upon the Mental and Physical Health of the Negro of the South,” Dr. J. F. Miller argued (falsely) that tuberculosis was a “rare” disease “among the negroes of the South prior to emancipation.” In truth, the disease was “rare” because enslaved people had no access to diagnosis and lived in a world where white physicians presumed that consumption among Black people was either uncommon or impossible. But Miller instead argued the real cause of the disease was that “even now, after thirty years or more of freedom, he [the Black person] takes but little thought for to-morrow, but to-morrow, nevertheless, comes to him and oftimes finds him wholly unprepared to meet its exacting demands.” Miller argued the only way to restore Black people to health was to return to the institution of slavery.

zygotes by definition are rather limited in number and most scientists working in very early development use cells from a bit later, the famous embryonic stem (ES) cells.

It didn’t matter what expressions were on those famous faces at the moment the future erupted from Goettreider’s device—skeptical, awed, distracted, amused, jealous, angry, thoughtful, frightened, detached, concerned, excited, nonchalant, harried, weary, cheeky, or wise—they were all fatally irradiated. Hematopoietic degradation leading to aplastic anemia, irregular cell division, genetic warping, gastrointestinal liquefaction and vascular collapse, catastrophic neurological damage, coma, prayer, death.

the Human Genome Project revealed that the human species cannot be divided into biological races. President Clinton famously announced, “I believe one of the great truths to emerge from this triumphant expedition inside the human genome is that in genetic terms, all human beings, regardless of race, are more than 99.9 percent the same.”75 Collins ended his remarks by saying, “I’m happy that today the only race that we are talking about is the human race.” Venter reported that Celera Genomics had sequenced the genomes of three women and two men who identified as Hispanic, Asian, Caucasian, and African American and found that “there’s no way to tell one ethnicity from another.” He bluntly declared, “Race has no genetic or scientific basis.

In 1921, Terman decided to make the study of the gifted his life work. Armed with a large grant from the Commonwealth Foundation, he put together a team of fieldworkers and sent them out into California’s elementary schools. Teachers were asked to nominate the brightest students in their classes. Those children were given an intelligence test. The students who scored in the top 10 percent were then given a second IQ test, and those who scored above 130 on that test were given a third IQ test, and from that set of results Terman selected the best and the brightest. By the time Terman was finished, he had sorted through the records of some 250,000 elementary and high school students, and identified 1,470 children whose IQs averaged over 140 and ranged as high as 200. That group of young geniuses came to be known as the “Termites,” and they were the subjects of what would become one of the most famous psychological studies in history. For the rest of his life, Terman watched over his charges like a mother hen. They were tracked and tested, measured and analyzed. Their educational attainments were noted, marriages followed, illnesses tabulated, psychological health charted, and every promotion and job change dutifully recorded. Terman wrote his recruits letters of recommendation for jobs and graduate school applications. He doled out a constant stream of advice and counsel, all the time recording his findings in thick red volumes entitled Genetic Studies of Genius.

Yet the idea that all humans are created equal is also a myth. In what sense do all humans equal one another? Is there any objective reality, outside the human imagination, in which we are truly equal? Are all humans equal to one another biologically? Let us try to translate the most famous line of the American Declaration of Independence into biological terms: "We hold these truths to be self-evident, that all men are created equal, the they are endowed by their Creator with certain unalienable rights, that among these are life, liberty, and the pursuit of happiness." According to the science of biology, people were not 'created'. They have evolved. And they certainly did not evolve to be 'equal'. The idea of equality is inextricably intertwined with the idea of creation. The Americans got the idea of equality from Christianity, which argues that every person has a divinely created soul, and that all souls are equal before God. However, if we do not believe in the Christian myths about God, creation and souls, what does it mean that all people are 'equal'? Evolution is based on difference, not on equality. Every person carries a somewhat different genetic code, and is exposed from birth to different environmental influences. This leads to the development of different qualities that carry with them different chances of survival. 'Created equal' should therefore be translated into 'evolved differently'. Just as people were never created, neither, according to the science of biology, is there a 'Creator" who 'endows" them with anything. There is only a blind evolutionary process, devoid of any purpose, leading to the birth of individuals. 'Endowed by their creator' should be translated simply into 'born'. Similarly, there are no such things as rights in biology. There are only organs, abilities and characteristics. Birds fly not because they have a right to fly, but because they have wings. And it's not true that these organs, abilities and characteristics are 'unalienable'. Many of them undergo constant mutilations, and may well be completely lost over time. The ostrich is a bird that lost its ability to fly. So 'unalienable rights' should be translated to 'mutable characteristics'. And what are the characteristics that evolved in humans? 'Life', certainly. But 'liberty'? There is no such thing in biology. Just like equality, rights and limited liability companies, liberty too is a political ideal rather than a biological phenomenon. From a purely biological viewpoint, there is little difference between the citizens of a republic and the subjects of a king. And what about 'happiness'? So far biological research has failed to come up with a clear definition of happiness or a way to measure it objectively. Most biological studies acknowledge only the existence of pleasure, which is more easily defined and measured. So 'life, liberty, and the pursuit of pleasure'. So here is that line from the American Declaration of Independence translated into biological terms: "We hold these truths to be self-evident, that all men evolved differently, that they are born with certain mutable characteristics' and that among these are life and the pursuit of pleasure." Advocates of equality and human rights may be outraged by this line of reasoning. Their response is likely to be, "We know that people are not equal biologically! But if we believe that we are all equal in essence, it will enable us to create a stable and prosperous society." I have no argument with that. This is exactly what I mean by 'imagined order". We believe in a particular order not because it is objectively true, but because believing in it enables us to cooperate effectively and forge a better society. Imagined orders are not evil conspiracies or useless mirages. Rather, they are the only way large numbers of humans can cooperate effectively.

Sir Walter Scott famously wrote, 'Oh what a tangled web we weave when first we practice to deceive.' Take some family history and politics, add cutting-edge military technology, mix in state-of-the-art genetics, top it off with next generation neurophysiology, and you have the ingredients for an elaborate deception. The untangling of the web of deception in Double Crossed presented an opportunity to incorporate elements of history, medicine, technology, and politics, all of which are longstanding interests of mine. The challenge was doing it gradually enough to sustain the reader's interest without giving away so much that it spoiled a surprise. We live in an age when no undertaking seems off limits, whether it be as simple as traditional spy craft, as overt as military intervention, or as sophisticated as cyber-espionage and ransomware. Although we do not currently possess the technology needed to pull off something as audacious and complex as what occurs in Double Crossed, that day is rapidly approaching.

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