Early Detection Quotes

Much like the removal of moles and skin lesions is done to prevent them from growing into more serious skin abnormalities, removing minor discord before it becomes a calamity is an important use of our time. Most people don’t like to make waves and they swallow frustration and bury true feelings, not wanting to compromise temporary tranquility, never realizing that massive turmoil doesn’t start out massive—it grows beneath the skin like a cancer that could have been avoided with early detection.

I don't greatly care for passes this early in the morning.

Have you ever felt, in the course of reading a detective novel, a guilty thrill of relief at having a character murdered before he can step onto the page and burden you with his actual existence? Detective stories always have too many characters anyway. And characters mentioned early on but never sighted, just lingering offstage, take on an awful portentous quality. Better to have them gone.

I was in the fifth grade the first time I thought about turning thirty. My best friend Darcy and I came across a perpetual calendar in the back of the phone book, where you could look up any date in the future, and by using this little grid, determine what the day of the week would be. So we located our birthdays in the following year, mine in May and hers in September. I got Wednesday, a school night. She got a Friday. A small victory, but typical. Darcy was always the lucky one. Her skin tanned more quickly, her hair feathered more easily, and she didn't need braces. Her moonwalk was superior, as were her cart-wheels and her front handsprings (I couldn't handspring at all). She had a better sticker collection. More Michael Jackson pins. Forenze sweaters in turquoise, red, and peach (my mother allowed me none- said they were too trendy and expensive). And a pair of fifty-dollar Guess jeans with zippers at the ankles (ditto). Darcy had double-pierced ears and a sibling- even if it was just a brother, it was better than being an only child as I was. But at least I was a few months older and she would never quite catch up. That's when I decided to check out my thirtieth birthday- in a year so far away that it sounded like science fiction. It fell on a Sunday, which meant that my dashing husband and I would secure a responsible baby-sitter for our two (possibly three) children on that Saturday evening, dine at a fancy French restaurant with cloth napkins, and stay out past midnight, so technically we would be celebrating on my actual birthday. I would have just won a big case- somehow proven that an innocent man didn't do it. And my husband would toast me: "To Rachel, my beautiful wife, the mother of my chidren and the finest lawyer in Indy." I shared my fantasy with Darcy as we discovered that her thirtieth birthday fell on a Monday. Bummer for her. I watched her purse her lips as she processed this information. "You know, Rachel, who cares what day of the week we turn thirty?" she said, shrugging a smooth, olive shoulder. "We'll be old by then. Birthdays don't matter when you get that old." I thought of my parents, who were in their thirties, and their lackluster approach to their own birthdays. My dad had just given my mom a toaster for her birthday because ours broke the week before. The new one toasted four slices at a time instead of just two. It wasn't much of a gift. But my mom had seemed pleased enough with her new appliance; nowhere did I detect the disappointment that I felt when my Christmas stash didn't quite meet expectations. So Darcy was probably right. Fun stuff like birthdays wouldn't matter as much by the time we reached thirty. The next time I really thought about being thirty was our senior year in high school, when Darcy and I started watching ths show Thirty Something together. It wasn't our favorite- we preferred cheerful sit-coms like Who's the Boss? and Growing Pains- but we watched it anyway. My big problem with Thirty Something was the whiny characters and their depressing issues that they seemed to bring upon themselves. I remember thinking that they should grow up, suck it up. Stop pondering the meaning of life and start making grocery lists. That was back when I thought my teenage years were dragging and my twenties would surealy last forever. Then I reached my twenties. And the early twenties did seem to last forever. When I heard acquaintances a few years older lament the end of their youth, I felt smug, not yet in the danger zone myself. I had plenty of time..

Children can be told anything—anything. I've always been struck by seeing how little grown-up people understand children, how little parents even understand their own children. Nothing should be concealed from children on the pretext that they are little and that it is too early for them to understand. What a miserable and unfortunate idea! And how readily the children detect that their fathers consider them too little to understand anything, though they understand everything. Grown-up people do not know that a child can give exceedingly good advice even in the most difficult case.

The goal of managing anxiety is not simply for relief, it is to connect more fully with God and to raise awareness of what God is doing. Anxiety blocks our awareness of God because it takes our subconscious attention. This means that anxiety can be an early detection system that we’re depending on something other than God for our

TRY: During the day, see if you can detect the bloom of the present moment in every moment, the ordinary ones, the “in-between” ones, even the hard ones. Work at allowing more things to unfold in your life without forcing them to happen and without rejecting the ones that don’t fit your idea of what “should” be happening. See if you can sense the “spaces” through which you might move with no effort in the spirit of Chuang Tzu’s cook. Notice how if you can make some time early in the day for being, with no agenda, it can change the quality of the rest of your day. By affirming first what is primary in your own being, see if you don’t get a mindful jump on the whole day and wind up more capable of sensing, appreciating, and responding to the bloom of each moment.

Now and then, all of this struck me as being not so much ridiculous as faintly ominous. What if, by chance, these early-stage symptoms didn’t pass? If the hints at hysteria, delusion, weak nerves and so on, that I thought I could detect in what she said, ended up leading to something more?

When you have an erratic, unpredictable, and aggressive parent, a child will detect signs and know when not to say something or know when to hide, so a threat-detecting sense begins to emerge early on. In the end, it wires the individual to be acutely aware and highly reactive to perceived threats.

must explain Henry early, to avoid disappointment. If I simply said he was a detective, and let it go at that, I should be obtaining the reader's interest under false pretences. He was really only a sort of detective, a species of sleuth. At Stafford's International Investigation Bureau, in the Strand,

A few weeks later alarms went off in an air defense bunker south of Moscow. A Soviet early-warning satellite had detected five Minuteman missiles approaching from the United States. The commanding officer on duty, Lieutenant Colonel Stanislav Petrov, tried to make sense of the warning. An American first strike would surely involve more than five missiles—but perhaps this was merely the first wave. The Soviet general staff was alerted, and it was Petrov’s job to advise them whether the missile attack was real. Any retaliation would have to be ordered soon. Petrov decided it was a false alarm. An investigation later found that the missile launches spotted by the Soviet satellite were actually rays of sunlight reflected off clouds.

I told you there was nothing to it,” said Arbuthnot apologetically. “But you know what it is—early hours of the morning—everything very still—the thing had a sinister look—like a detective story. All nonsense, really.

The idea that there could be one solution to breast cancer- screening, early detection, some universal cure- is certainly appealing. All of us, those who fear the disease, those who live with it, our friends and families, the corporations who swath themselves in pink, wish it were true. Wearing a bracelet, sporting a ribbon, running a race, or buying a pink blender expresses our hopes and that feels good - even virtuous. But making a difference is more complicated than that.

Edgar Allan Poe was an American poet, short story writer, playwright, editor, critic, essayist and one of the leaders of the American Romantic Movement. Best known for his tales of the macabre and mystery, Poe was one of the early American practitioners of the short story and a progenitor of detective fiction and crime fiction. He is also credited with contributing to the emergent science fiction genre.Poe died at the age of 40. The cause of his death is undetermined and has been attributed to alcohol, drugs, cholera, rabies, suicide (although likely to be mistaken with his suicide attempt in the previous year), tuberculosis, heart disease, brain congestion and other agents. Source: Wikipedia

We called ourselves The Reasonably Good Band, but in fact we weren't. Our intention was to be the Beatles of the early eighties, but we got much better financial and legal advice than the Beatles ever did, which was basically 'Don't bother,' so we didn't. I left Cambridge and starved for three years.

Then one night a report about breast cancer came on the news, all about mammograms and early detection, women talking about finding a lump in their breast. We were making dinner. We always turned the television off when we sat down to eat but we could watch it while we were cooking. That was the rule. “I have one of those,” she said to the television set. “You had a mammogram?” She shook her head. She wasn’t looking at me. “A lump.” I had been cutting up a head of broccoli and I put down the knife and washed my hands. “What did you do about it?” “I didn’t do anything about it.” “What did the doctor say?” She looked at me then. “The whole thing scared me to death.” “So what happened?” My brain insisted on hearing it in the past tense, I had a lump in my breast once. I couldn’t understand that this was something that was happening. “I thought I’d wait for you to come home,” she said. “You’re always so good at figuring things out.” “I’ve been home three months.” But she had found the lump a year before, and taped a gauze square over it when it started to leak. When I looked at her again I could actually see a disruption in the pattern of her dress. That’s how big it was. Once we started making the hopeless rounds of oncologist appointments, the past broke away. All the things I’d thought about myself before—I am an actress, I am not an actress, I was in love, I was betrayed—disintegrated into nothing. I made bowls of Cream of Wheat she wouldn’t eat and then scraped them into the trash once they turned cold. I managed the schedule of people who wanted to come and see her, her two sons and two daughters—one of those daughters my mother—my father, my brothers, all my cousins, all her friends. I made sure no one stayed too long. I sat by her bed and read to her.

Criminal law, in which the state detects the offence, takes the accused to court and demands and imposes punishment, simply did not exist in early medieval society.

Obnoxious little brothers make great early-detection systems for embarrassing moments.

Normally, I don't take to drinking so early in the morning, but I bend the rules when I get my ass kicked before sunrise."--Thomas Morelli

I think I have found a set of biomarkers. Not from tissue biopsy—blood biomarkers. Noninvasive, easy to obtain. Cheap. In mice they can detect pancreatic cancer as early as stage one.

1. The criminal must be mentioned in the early part of the story, but must not be anyone whose thoughts the reader has been allowed to know. 2. All supernatural or preternatural agencies are ruled out as a matter of course. 3. Not more than one secret room or passage is allowable. 4. No hitherto undiscovered poisons may be used, nor any appliance which will need a long scientific explanation at the end. 5. No Chinaman must figure in the story. 6. No accident must ever help the detective, nor must he ever have an unaccountable intuition which proves to be right. 7. The detective himself must not commit the crime. 8. The detective is bound to declare any clues which he may discover. 9. The "sidekick" of the detective, the Watson, must not conceal from the reader any thoughts which pass through his mind: his intelligence must be slightly, but very slightly, below that of the average reader. 10. Twin brothers, and doubles generally, must not appear unless we have been duly prepared for them.

During much of the nineteenth and early twentieth centuries, private detective agencies had filled the vacuum left by decentralized, underfunded, incompetent, and corrupt sheriff and police departments.

From the vantage of the early twenty-first century, it might be more accurate to say, with no disrespect, that Arthur Conan Doyle originated Sherlock Holmes. The rest of us, obviously, aren’t yet finished creating him.

We called ourselves The Reasonably Good Band, but in fact we weren’t. Our intention was to be the Beatles of the early eighties, but we got much better financial and legal advice than the Beatles ever did, which was basically ‘Don’t bother,

We live on the edge of the future and detect signals early on by accessing a wide variety of people, ideas and information. But to benefit from this sensitivity, you need the support of people who are ready to engage and the patience to act when the moment is right.

and the vestiges of that early feeling were still there, as she could not bring herself to punish the snails or caterpillars for their depredations. They were her fellow creatures, after all. They had not asked to be snails or caterpillars, and they needed to eat, as we all did.

Let us spend one day as deliberately as Nature, and not be thrown off the track by every nutshell and mosquito's wing that falls on the rails. Let us rise early and fast, or break fast, gently and without perturbation; let company come and let company go, let the bells ring and the children cry, -- determined to make a day of it. Why should we knock under and go with the stream? Let us not be upset and overwhelmed in that terrible rapid and whirlpool called a dinner, situated in the meridian shallows. Weather this danger and you are safe, for the rest of the way is down hill. With unrelaxed nerves, with morning vigor, sail by it, looking another way, tied to the mast like Ulysses. If the engine whistles, let it whistle till it is hoarse for its pains. If the bell rings, why should we run? We will consider what kind of music they are like. Let us settle ourselves, and work and wedge our feet downward through the mud and slush of opinion, and prejudice, and tradition, and delusion, and appearance, that alluvion which covers the globe, through Paris and London, through New York and Boston and Concord, through church and state, through poetry and philosophy and religion, till we come to a hard bottom and rocks in place, which we can call reality, and say, This is, and no mistake; and then begin, having a point d'appui, below freshet and frost and fire, a place where you might found a wall or a state, or set a lamp-post safely, or perhaps a gauge, not a Nilometer, but a Realometer, that future ages might know how deep a freshet of shams and appearances had gathered from time to time. If you stand right fronting and face to face to a fact, you will see the sun glimmer on both its surfaces, as if it were a cimeter, and feel its sweet edge dividing you through the heart and marrow, and so you will happily conclude your mortal career. Be it life or death, we crave only reality. If we are really dying, let us hear the rattle in our throats and feel cold in the extremities; if we are alive, let us go about our business. Time is but the stream I go a-fishing in. I drink at it; but while I drink I see the sandy bottom and detect how shallow it is. Its thin current slides away, but eternity remains. I would drink deeper; fish in the sky, whose bottom is pebbly with stars. I cannot count one. I know not the first letter of the alphabet. I have always been regretting that I was not as wise as the day I was born. The intellect is a cleaver; it discerns and rifts its way into the secret of things. I do not wish to be any more busy with my hands than is necessary. My head is hands and feet. I feel all my best faculties concentrated in it. My instinct tells me that my head is an organ for burrowing, as some creatures use their snout and fore-paws, and with it I would mine and burrow my way through these hills. I think that the richest vein is somewhere hereabouts; so by the divining rod and thin rising vapors I judge; and here I will begin to mine.

Two large trials of antioxidants were set up after Peto’s paper (which rather gives the lie to nutritionists’ claims that vitamins are never studied because they cannot be patented: in fact there have been a great many such trials, although the food supplement industry, estimated by one report to be worth over $50 billion globally, rarely deigns to fund them). One was in Finland, where 30,000 participants at high risk of lung cancer were recruited, and randomised to receive either ß-carotene, vitamin E, or both, or neither. Not only were there more lung cancers among the people receiving the supposedly protective ß-carotene supplements, compared with placebo, but this vitamin group also had more deaths overall, from both lung cancer and heart disease. The results of the other trial were almost worse. It was called the ‘Carotene and Retinol Efficacy Trial’, or ‘CARET’, in honour of the high p-carotene content of carrots. It’s interesting to note, while we’re here, that carrots were the source of one of the great disinformation coups of World War II, when the Germans couldn’t understand how our pilots could see their planes coming from huge distances, even in the dark. To stop them trying to work out if we’d invented anything clever like radar (which we had), the British instead started an elaborate and entirely made-up nutritionist rumour. Carotenes in carrots, they explained, are transported to the eye and converted to retinal, which is the molecule that detects light in the eye (this is basically true, and is a plausible mechanism, like those we’ve already dealt with): so, went the story, doubtless with much chortling behind their excellent RAF moustaches, we have been feeding our chaps huge plates of carrots, to jolly good effect. Anyway. Two groups of people at high risk of lung cancer were studied: smokers, and people who had been exposed to asbestos at work. Half were given 3-carotene and vitamin A, while the other half got placebo. Eighteen thousand participants were due to be recruited throughout its course, and the intention was that they would be followed up for an average of six years; but in fact the trial was terminated early, because it was considered unethical to continue it. Why? The people having the antioxidant tablets were 46 per cent more likely to die from lung cancer, and 17 per cent more likely to die of any cause,* than the people taking placebo pills. This is not news, hot off the presses: it happened well over a decade ago.

Are we running hot or something?" Peabody demanded. "So a person can't take a minute to have a cup of coffee and maybe a small bite to eat, especially when the person got off a full subway stop early to work off the anticipated bite to eat." "If you're finished whining about it, I'll fill you in." "A real partner would have brought me a coffee to go so I could drink it while being filled in." "How many coffee shops did you pass on your endless and arduous hike from the subway?" "It's not the same," Peabody muttered. "And it's not my fault I'm coffee spoiled. You're the one who brought the real stufff made from real beans into my life. You addicted me." She pointed an accusing finger at Eve. "And now you're withholding the juice." "Yes, that was my plan all along. And if you ever want real again in this lifetime, suck it up and do my bidding." Peabody stared. "You're like Master Manipulator. An evil coffee puppeteer." "Yes, yes, I am. Do you have any interest, Detective, in where we're going, who we're going to see, and why?" "I'd be more interested if I had coffee.

During much of the nineteenth and early twentieth centuries, private detective agencies had filled the vacuum left by decentralized, underfunded, incompetent, and corrupt sheriff and police departments. In literature and in the popular imagination, the all-seeing private eye—the gumshoe, the cinder dick, the sleuthhound, the shadow—displaced the crusading sheriff as the archetype of rough justice.

I have read also," he said, "some of the early works of Mrs.Ariadne Oliver. She is by way of being a friend of mine,and of yours, I think. I do not wholly approve of her works, mind you. The happenings in them are highly improbable. The long arm of coincidence is far too freely employed. And being young at the time, she was foolish enough to make her detective a Finn, and it is clear that she knows nothing about Finns or Finland except possibly the works of Sibelius.

As soon as all the prizes had been given out, the band began to play a lively dance number. Rod Havelock, who had been watching closely, came up to claim Nancy and was only a second ahead of Al. “I guess I’d better get my dances in early,” the assistant purser teased. “I see I have a handsome rival.” Nancy laughed as they glided off. “I’m glad you did, because I must ask you a question. We are planning to open the mystery trunk tonight after this party is over. Will you come and help us investigate it?” “You bet I will,” Rod replied. “I can tell you now that the dancing will end at eleven o’clock sharp. Shall we say eleven-fifteen in your room?” “Perfect,” Nancy agreed. At this moment the music ended. Others came up to talk to the couple, and presently AI made his way toward Nancy. “May I have the next dance?” he asked. The whole evening was a joyful one for Nancy and her friends. They were claimed for every dance. Al asked the girl detective if she would accompany him to the lavish table of food that had been set up on the deck outside. She went along and they found Bess, George, and Nelda there with Bruce, Chipper, and Tubby. “Hey, have some of those delicious meatballs!” Tubby recommended. “Now, Tub, I thought you were staying away from all this fattening stuff?” Chipper teased. “Well, I had to try a little of each!” Tubby defended himself. When the music began to play again, Al asked Nancy to dance. “Sure, I’d like to,” she said. “I’m glad you would,” Al commented. “Next to football, dancing is my favorite pastime.

IN OCTOBER 2019, just a few months before the novel coronavirus swept the world, Johns Hopkins University released its first Global Heath Security Index, a comprehensive analysis of countries that were best prepared to handle an epidemic or pandemic. The United States ranked first overall, and first in four of the six categories—prevention, early detection and reporting, sufficient and robust health system, and compliance with international norms. That sounded right. America was, after all, the country with most of the world’s best pharmaceutical companies, research universities, laboratories, and health institutes. But by March 2020, these advantages seemed like a cruel joke, as Covid-19 tore across the United States and the federal government mounted a delayed, weak, and erratic response. By July, with less than 5% of the world’s population, the country had over 25% of the world’s cumulative confirmed cases. Per capita daily death rates in the United States were ten times higher than in Europe. Was this the new face of American exceptionalism?

The type that is ‘sensitive’ or ‘reactive’ would reflect a strategy of observing carefully before acting,” she writes, “thus avoiding dangers, failures, and wasted energy, which would require a nervous system specially designed to observe and detect subtle differences. It is a strategy of ‘betting on a sure thing’ or ‘looking before you leap.’ In contrast, the active strategy of the [other type] is to be first, without complete information and with the attendant risks—the strategy of ‘taking a long shot’ because the ‘early bird catches the worm’ and ‘opportunity only knocks once.’ 

If they would have acknowledged this [SARS] early, and we could have seen the virus as it occurred in south China, we probably could have isolated it before it got out of hand,” explained one infectious disease expert. “But they completely hid it. They hide everything. You can’t even find out how many people die from earthquakes.”2438 The foundation of the theoretical models is openness and cooperation for rapid detection of outbreaks of influenza. “Would they admit to it if it was here?” one Asian diplomat asked. “That’s the big question, since they deny everything left, right and center.

I started by collecting copies of all the novels and short stories featuring him and piled them up beside my bed. I wanted to get to the very heart of what Dame Agatha thought of him and what he was really like, and to do that, I had to read every word his creator had ever written about him. I didn’t want my Poirot to be a caricature, something made up in a film or television studio, I wanted him to be real, as real as he was in the books, as real as I could possibly make him. The first thing I realised was that I was a slightly too young to play him. He was a retired police detective in his sixties when he first appeared in The Mysterious Affair at Styles, while I was in my early forties. Not only that, he was also described as a good deal fatter than I was. There was going to have to be some considerable padding, not to mention very careful make-up and costume, if I was going to convince the world that I was the great Hercule Poirot. Even more important, the more I read about him, the more convinced I became that he was a character that demanded to be taken seriously. He wasn’t a silly little man with a funny accent, any more than Sherlock Holmes was just a morphine addict with a taste for playing the violin. There was a depth and quality to the Poirot that Dame Agatha had created – and that was what I desperately wanted to bring to the screen.

there are so many more facts, now that I have not to invent them. How can I disinter the human character from the heavy scene—the daily newspaper, the daily meal, the traffic grinding towards Battersea, the gulls coming up from the Thames looking for bread, and the early summer of 1939 glinting on the park where the children sailed their boats—one of those bright condemned pre-war summers? I wondered whether, if I thought long enough, I could detect, at the party Henry had given, her future lover. We saw each other for the first time, drinking bad South African sherry because of the war in Spain. I noticed Sarah, I think, because she was happy: in those years the sense of happiness had been a long while dying under the coming storm.

Bumblebees detect the polarization of sunlight, invisible to uninstrumented humans; put vipers sense infrared radiation and detect temperature differences of 0.01C at a distance of half a meter; many insects can see ultraviolet light; some African freshwater fish generate a static electric field around themselves and sense intruders by slight perturbations induced in the field; dogs, sharks, and cicadas detect sounds wholly inaudible to humans; ordinary scorpions have micro--seismometers on their legs so they can detect in darkness the footsteps of a small insect a meter away; water scorpions sense their depth by measuring the hydrostatic pressure; a nubile female silkworm moth releases ten billionths of a gram of sex attractant per second, and draws to her every male for miles around; dolphins, whales, and bats use a kind of sonar for precision echo-location. The direction, range, and amplitude of sounds reflected by to echo-locating bats are systematically mapped onto adjacent areas of the bat brain. How does the bat perceive its echo-world? Carp and catfish have taste buds distributed over most of their bodies, as well as in their mouths; the nerves from all these sensors converge on massive sensory processing lobes in the brain, lobes unknown in other animals. how does a catfish view the world? What does it feel like to be inside its brain? There are reported cases in which a dog wags its tail and greets with joy a man it has never met before; he turns out to be the long-lost identical twin of the dog's "master", recognizable by his odor. What is the smell-world of a dog like? Magnetotactic bacteria contain within them tiny crystals of magnetite - an iron mineral known to early sailing ship navigators as lodenstone. The bacteria literally have internal compasses that align them along the Earth's magnetic field. The great churning dynamo of molten iron in the Earth's core - as far as we know, entirely unknown to uninstrumented humans - is a guiding reality for these microscopic beings. How does the Earth's magnetism feel to them? All these creatures may be automatons, or nearly so, but what astounding special powers they have, never granted to humans, or even to comic book superheroes. How different their view of the world must be, perceiving so much that we miss.

...if we are to keep alive the model of sustainable metropolitan life that Snow and Whitehead helped make possible 150 years ago, it is incumbent on us to do, at the very least, two things. The first is to embrace—as a matter of philosophy and public policy—the insights of science... The second is to commit ourselves anew to the kinds of public health systems that developed in the wake of the Broad Street outbreak, both in the developed world and the developing: clean water supplies, sanitary waste-removal and recycling systems, early vaccination programs, disease detection and mapping programs. Cholera demonstrated that the nineteenth-century world was more connected than ever before; that local public-health problems could quickly reverberate around the globe.

His reading habit was so varied that in his early teens, he was reading both Maxim Gorky’s Mother and the detective thrillers (Jasoosi Duniya) of Ibn-e-Safi. The detective thrillers—be it Indian or American pulp fiction—were a big favourite for their fast action, tight plots and economies of expression. He remembers the novels of Ibn-e-Safi for their fascinating characters with memorable names. ‘Ibn-e-Safi was a master at naming his characters. All of us who read him remember those names . . . There was a Chinese villain, his name was Sing Hi. There was a Portuguese villain called Garson . . . an Englishman who had come to India and was into yoga . . . was called Gerald Shastri.’ This technique of giving catchy names to characters would stay with him. The wide range of reading not only gave him the sensitivity with which progressive writers approached their subjects but also a very good sense of plot and speaking styles. Here, it would be apt to quote a paragraph from Ibn-e-Safi’s detective novel, House of Fear—featuring his eccentric detective, Imran. The conversation takes place just outside a nightclub: ‘So, young man. So now you have also starred frequenting these places?’ ‘Yes. I often come by to pay Flush,’ Imran said respectfully. ‘Flush! Oh, so now you play Flush . . .’ ‘Yes, yes. I feel like it when I am a bit drunk . . .’ ‘Oh! So you have also started drinking?’ ‘What can I say? I swear I’ve never drunk alone. Frequently I find hookers who do not agree to anything without a drink . . .’ This scene would find a real-life parallel as well as a fictional one in Javed’s life later. Javed

The historian Pieter Spierenburg has provocatively suggested that “democracy came too early” to America.85 In Europe, first the state disarmed the people and claimed a monopoly on violence, then the people took over the apparatus of the state. In America, the people took over the state before it had forced them to lay down their arms – which, as the Second Amendment famously affirms, they reserve the right to keep and bear. In other words Americans, and especially Americans in the South and West, never fully signed on to a social contract that would vest the government with a monopoly on the legitimate use of force. In much of American history, legitimate force was also wielded by posses, vigilantes, lynch mobs, company police, detective agencies, and Pinker-tons, and even more often kept as a prerogative of the individual.

Imagine for a moment what the brain must do to ignore (and eventually prune) the neurological processes that identify a dangerous mother? It must compartmentalize fear somewhere outside your consciousness so that bonding can happen. Over time, the brain shrinks danger signals, like a mother’s shrill voice or furrowed brow, so you can tolerate her proximity. Pruning alters perception and protects you when you are small and dependent, but over time, your innate ability to detect or discern risky situations is twisted. In this way, neuroception is altered, which is why exposure to early betrayal puts you at a greater risk of further victimization. Maternal abuse is a devastating betrayal because not only do you miss out on essential nurturance, protection, and guidance, but your neuroception and protective instincts are also damaged.

The Name "Arthur" The etymology of the Welsh name Arthur is uncertain, though most scholars favour either a derivation from the Roman gens name Artorius (ultimately of Messapic or Etruscan origin), or a native Brittonic compound based on the root *arto- "bear" (which became arth in Medieval and Modern Welsh). Similar "bear" names appear throughout the Celtic-speaking world. Gildas does not give the name Arthur but he does mention a British king Cuneglasus who had been "charioteer to the bear". Those that favor a mythological origin for Arthur point out that a Gaulish bear goddess Artio is attested, but as yet no certain examples of Celtic male bear gods have been detected. John Morris argues that the appearance of the name Arthur, as applied to the Scottish, Welsh and Pennine "Arthurs", and the lack of the name at any time earlier, suggests that in the early 6th century the name became popular amongst the indigenous British for a short time. He proposes that all of these occurrences were due to the importance of another Arthur, who may have ruled temporarily as Emperor of Britain. He suggests on the basis of archaeology that a period of Saxon advance was halted and turned back, before resuming again in the 570s. Morris also suggests that the Roman Camulodunum, modern Colchester, and capital of the Roman province of Britannia, is the origin of the name "Camelot". The name Artúr is frequently attested in southern Scotland and northern England in the 7th and 8th centuries. For example, Artúr mac Conaing, who may have been named after his uncle Artúr mac Áedáin. Artúr son of Bicoir Britone, was another 'Arthur' reported in this period, who slew Morgan mac Fiachna of Ulster in 620/625 in Kintyre. A man named Feradach, apparently the grandson of an 'Artuir', was a signatory at the synod that enacted the Law of Adomnan in 697. Arthur ap Pedr was a prince in Dyfed, born around 570–580. Given the popularity of this name at the time, it is likely that others were named for a figure who was already established in folklore by that time.

Our ability to believe in supernatural agents may well have begun as an accidental by-product of a hypersensitive agency detection device, but once early humans began believing in such agents, the groups that used them to construct moral communities were the ones that lasted and prospered. Like those nineteenth-century religious communes, they used their gods to elicit sacrifice and commitment from members. Like those subjects in the cheating studies and trust games, their gods helped them to suppress cheating and increase trustworthiness. Only groups that can elicit commitment and suppress free riding can grow. This is why human civilization grew so rapidly after the first plants and animals were domesticated. Religions and righteous minds had been coevolving, culturally and genetically, for tens of thousands of years before the Holocene era, and both kinds of evolution sped up when agriculture presented new challenges and opportunities. Only groups whose gods promoted cooperation, and whose individual minds responded to those gods, were ready to rise to these challenges and reap the rewards.

Before the event it is too early for the possible. After the event it is too late for the possible. It is too late also for representation, and nothing will really be able to account for it. September 11 th, for example, is there first - only then do its possibility and its causes catch up with it, through all the discourses that will attempt to explain it. But it is as impossible to represent that event) as it was to forecast it before it occurred. The CIA's experts had at their disposal all the information on the possibility of an attack, but they simply didn't believe in it. It was beyond imagining. Such an event always is. It is beyond all possible causes (and perhaps even, as Italo Svevo suggests, causes are merely a misunderstanding that prevents the world from being what it is). We have, then, to pass through the non-event of news coverage (information) to detect what resists that coverage. To find, as it were, the 'living coin' of the event. To make a literal analysis of it, against all the machinery of commentary and stage-management that merely neutralizes it. Only events set free from news and information (and us with them) create a fantastic longing. These alone are 'real', since there is nothing to explain them and the imagination welcomes them with open arms.

Soon all humane people would understand the need for a revolution from below, where those who worked and struggled and produced would be the ruling class. Those with eyes to see could detect this with ease, while those whose eyes had yet to be opened could always… well, it was thought that events would also assist in persuading them. I realize that this may sound slightly as if I had joined a cult. There actually was a rival Trotskyist group, later to make itself notorious by recruiting Corin and Vanessa Redgrave, whose depraved “leader” Gerry Healy did in fact teach us all we needed to learn about cultism and the mental and sexual and financial exploitation of the young and the credulous. (I learned a lot about “faith-based” movements from this early instruction.) But the “I.S.,” as our group was known, had a relaxed and humorous internal life and also a quizzical and critical attitude to the “Sixties” mindset. We didn’t grow our hair too long, because we wanted to mingle with the workers at the factory gate and on the housing estates. We didn’t “do” drugs, which we regarded as a pathetic, weak-minded escapism almost as contemptible as religion (as well as a bad habit which could expose us to a “plant” from the police). Rock and roll and sex were OK. Looking back, I still think we picked the right options.

Perhaps the most amazing practitioner of echolocation among humans is Daniel Kish, blind since he was one year old, who early in life discovered that making clicking noises helped him get around. Much of his brain must be reassigned to sound, because he uses his own clicks to navigate. He can ride a bicycle in traffic (hard to imagine), and he has founded World Access for the Blind to teach other blind people to use their own sonar—to summon, as it were, their inner dolphin. Sounds from his tongue clicks, he explains, “bounce off surfaces all around and return to my ears as faint echoes. My brain processes the echoes into dynamic images.… I construct a three-dimensional image of my surroundings for hundreds of feet in every direction. Up close, I can detect a pole an inch thick. At 15 feet, I recognize cars and bushes. Houses come into focus at 150 feet.” This is all so hard to imagine, people have wondered if he is telling the truth. But he’s not alone, and his claims appear to check out. He says, “Many students are surprised how quickly results come. I believe echolocation capacity is latent within us.… The neural hardware seems to be there; I’ve developed ways to activate it. Vision isn’t in the eyes; it’s in the mind.” So, is it possible that a dolphin such as a killer whale might actually see the echoes?

The story begins with the revelation Alicia murdered her husband. Why do you think the author made this admission at the very start?   2.  Alicia’s diary plays a key role in the book. What purpose do you think it serves? And does your perception of Alicia change the more you read?   3.  Alicia’s silence is related to the Greek myth of Alcestis. How do you feel about the story of the myth? Why do you think Alicia is silent?   4.  Theo’s motives to work with Alicia are complicated. Do you think he wanted to help her?   5.  Both Alicia and Theo had difficult childhoods. Early on, Theo says no one is born evil. That who we become depends on the environment into which we are born. By the end of the novel he appears to change his mind, saying that perhaps some of us are born evil, and, despite therapy, we remain that way. Which do you think is true?   6.  Weather plays a large role in the book, such as the heat wave during the summer. What purpose do you think the description of the weather serves in the novel?   7.  Do you think the world of a psychiatric unit was convincingly portrayed? How do you feel about Diomedes and the other psychiatrists?   8.  We never enter Kathy’s mind in the book. Do you have any sympathy for her?   9.  What do you think happens at the end of the book? The last line is ambiguous. 10.  It’s a psychological thriller with a twist. The author has said he was influenced by Agatha Christie. Did you feel this was simply a detective story or are there any other influences you can spot?

Add your typical shower and claw feet Owners claw foot tub, consider incorporating the most traditional sense of joy in the ease and comfort revolutionary shower, governments are mainly engaged in the race just to check in early for power within very ready. Clawfoot tubs wear’s now includes a shower; there are many strategies to use the shower in the bathroom now. Even if a person must be determined in those particular individual hairs, can be costly and impractical. Although the site has a separate shower grow, keep in mind that you want the products and save more modern maintenance. Value management easier and more efficient to add a shower curtain and bath address. The information is not expensive, there are some ideas that you can include in the acquired shower. Contractor or plumber can provide ideas and even to make for you. The original can take water heater shower bath in the direction of the feet and the creation of a rod with an en suite shower room, and when the curtain. Shower curtains apartment surrounded significantly reduces splash of water leaks. Another option would be surplus tiles on the long term, the use of H2O "enemy" and shower rod and curtain also furnished, "L" of the aspects described in determining the bath. What will be more expensive and bathroom alone for a long time, some people are afraid of this option. On the way to the drain in the shower, you could be the cables hidden in the bathroom near the wall. The second course in the HVAC responsible for pre-tube immediately describes the bath to the option in the direction of the traditional classical appearance. There are several different types of decorative lighting and lids which are made in such a way that appears to choose in the hoses pin and presented a lot of good taste on the market. For those who are willing to deal with their own tasks, traders improving the registered owner of the Depot and Lowe's contain a number of "do it yourself" kits are unique measurements. Such kits are barrels and other containers, as defined above use’s shower built for joint legs. Everything requires a few simple policies and lower resistance to the purchase is detected. This kind of "precursors" of the water, you can judge for yourself in the shower longitudinal shower, shower curtains and thoughts. If you take even more concerned that the easiest only independent bathroom each provider in the health of office workers only in the direction of the support of others and crank implementing rules. Have a good friend or spouse and children of a member who keep an eye on your health, as it is commonly known. No need for the resolution, that the decision to migrate to an item in the shower of his classic bathroom was somewhat effortlessly came to rise. It goes in the direction of maximizing claw foot tub, or take an impressive ease of use aerosol own desire. Many decisions wonderful shower curtain in the direction of the changes the rest of the room was coming towards a holistic view of their cosmetics, and a lot of fun to drive in the direction of your claw foot tub.

If loneliness or sadness or happiness could be expressed through food, loneliness would be basil. It’s not good for your stomach, dims your eyes, and turns your mind murky. If you pound basil and place a stone over it, scorpions swarm toward it. Happiness is saffron, from the crocus that blooms in the spring. Even if you add just a pinch to a dish, it adds an intense taste and a lingering scent. You can find it anywhere but you can’t get it at any time of the year. It’s good for your heart, and if you drop a little bit in your wine, you instantly become drunk from its heady perfume. The best saffron crumbles at the touch and instantaneously emits its fragrance. Sadness is a knobby cucumber, whose aroma you can detect from far away. It’s tough and hard to digest and makes you fall ill with a high fever. It’s porous, excellent at absorption, and sponges up spices, guaranteeing a lengthy period of preservation. Pickles are the best food you can make from cucumbers. You boil vinegar and pour it over the cucumbers, then season with salt and pepper. You enclose them in a sterilized glass jar, seal it, and store it in a dark and dry place. WON’S KITCHEN. I take off the sign hanging by the first-floor entryway. He designed it by hand and silk-screened it onto a metal plate. Early in the morning on the day of the opening party for the cooking school, he had me hang the sign myself. I was meaning to give it a really special name, he said, grinning, flashing his white teeth, but I thought Jeong Ji-won was the most special name in the world. He called my name again: Hey, Ji-won. He walked around the house calling my name over and over, mischievously — as if he were an Eskimo who believed that the soul became imprinted in the name when it was called — while I fried an egg, cautiously sprinkling grated Emmentaler, salt, pepper, taking care not to pop the yolk. I spread the white sun-dried tablecloth on the coffee table and set it with the fried egg, unsalted butter, blueberry jam, and a baguette I’d toasted in the oven. It was our favorite breakfast: simple, warm, sweet. As was his habit, he spread a thick layer of butter and jam on his baguette and dunked it into his coffee, and I plunked into my cup the teaspoon laced with jam, waiting for the sticky sweetness to melt into the hot, dark coffee. I still remember the sugary jam infusing the last drop of coffee and the moist crumbs of the baguette lingering at the roof of my mouth. And also his words, informing me that he wanted to design a new house that would contain the cooking school, his office, and our bedroom. Instead of replying, I picked up a firm red radish, sparkling with droplets of water, dabbed a little butter on it, dipped it in salt, and stuck it into my mouth. A crunch resonated from my mouth. Hoping the crunch sounded like, Yes, someday, I continued to eat it. Was that the reason I equated a fresh red radish with sprouting green tops, as small as a miniature apple, with the taste of love? But if I cut into it crosswise like an apple, I wouldn't find the constellation of seeds.

Three-and-a-half-month-old infants already seem to exhibit the other-race effect. In a study at the University of Kentucky, white babies were very good at distinguishing faces with 100 percent Caucasian features from faces that had been graphically morphed to include features that were 70 percent white and 30 percent Asian. They couldn’t do the reverse: They could not tell 100 percent Asian faces from those that were morphed to include 30 percent white features. In other words, they could detect small differences between white and not-quite-white faces, but not the same kinds of differences between Asian and not-quite-Asian faces. Lawrence A. Hirschfeld of the University of Michigan did some of the pioneering work on how early in life children begin to understand race. He showed children of ages three, four, and seven, a picture of “Johnny:” a chubby black boy in a police uniform, complete with whistle and toy gun. He then showed them pictures of adults who shared two of Johnny’s three main traits of race, body build, and uniform. Prof. Hirschfeld prepared all combinations—policemen who were fat but were white, thin black policemen, etc.—and asked the children which was Johnny’s daddy or which was Johnny all grown up. Even the three-year-olds were significantly more likely to choose the black man rather than the fat man or the policeman. They knew that weight and occupation can change but race is permanent. In 1996, after 15 years of studying children and race, Prof. Hirschfeld concluded: “Our minds seem to be organized in a way that makes thinking racially—thinking that the human world can be segmented into discrete racial populations—an almost automatic part of our mental repertoire.” When white preschoolers are shown racially ambiguous faces that look angry, they tend to say they are faces of blacks, but categorize happy faces as white. “These filters through which people see the world are present very early,” explained Andrew Baron of Harvard. Phyllis Katz, then a professor at the University of Colorado, studied young children for their first six years. At age three, she showed them photographs of other children and asked them whom they would like to have as friends. Eighty-six percent of white children chose photographs of white children. At age five and six, she gave children pictures of people and told them to sort them into two piles by any criteria they liked. Sixty-eight percent sorted by race and only 16 by sex. Of her entire six-year study Prof. Katz said, “I think it is fair to say that at no point in the study did the children exhibit the Rousseau type of color-blindness that many adults expect.

The key point is that these patterns, while mostly stable, are not permanent: certain environmental experiences can add or subtract methyls and acetyls, changing those patterns. In effect this etches a memory of what the organism was doing or experiencing into its cells—a crucial first step for any Lamarck-like inheritance. Unfortunately, bad experiences can be etched into cells as easily as good experiences. Intense emotional pain can sometimes flood the mammal brain with neurochemicals that tack methyl groups where they shouldn’t be. Mice that are (however contradictory this sounds) bullied by other mice when they’re pups often have these funny methyl patterns in their brains. As do baby mice (both foster and biological) raised by neglectful mothers, mothers who refuse to lick and cuddle and nurse. These neglected mice fall apart in stressful situations as adults, and their meltdowns can’t be the result of poor genes, since biological and foster children end up equally histrionic. Instead the aberrant methyl patterns were imprinted early on, and as neurons kept dividing and the brain kept growing, these patterns perpetuated themselves. The events of September 11, 2001, might have scarred the brains of unborn humans in similar ways. Some pregnant women in Manhattan developed post-traumatic stress disorder, which can epigenetically activate and deactivate at least a dozen genes, including brain genes. These women, especially the ones affected during the third trimester, ended up having children who felt more anxiety and acute distress than other children when confronted with strange stimuli. Notice that these DNA changes aren’t genetic, because the A-C-G-T string remains the same throughout. But epigenetic changes are de facto mutations; genes might as well not function. And just like mutations, epigenetic changes live on in cells and their descendants. Indeed, each of us accumulates more and more unique epigenetic changes as we age. This explains why the personalities and even physiognomies of identical twins, despite identical DNA, grow more distinct each year. It also means that that detective-story trope of one twin committing a murder and both getting away with it—because DNA tests can’t tell them apart—might not hold up forever. Their epigenomes could condemn them. Of course, all this evidence proves only that body cells can record environmental cues and pass them on to other body cells, a limited form of inheritance. Normally when sperm and egg unite, embryos erase this epigenetic information—allowing you to become you, unencumbered by what your parents did. But other evidence suggests that some epigenetic changes, through mistakes or subterfuge, sometimes get smuggled along to new generations of pups, cubs, chicks, or children—close enough to bona fide Lamarckism to make Cuvier and Darwin grind their molars.

Sophie?” He knocked, though not that hard, then decided she wasn’t going hear anything less than a regiment of charging dragoons over Kit’s racket. He pushed the door open to find half of Sophie’s candles lit and the lady pacing the room with Kit in her arms. “He won’t settle,” she said. “He isn’t wet; he isn’t hungry; he isn’t in want of cuddling. I think he’s sickening for something.” Sophie looked to be sickening. Her complexion was pale even by candlelight, her green eyes were underscored by shadows, and her voice held a brittle, anxious quality. “Babies can be colicky.” Vim laid the back of his hand on the child’s forehead. This resulted in a sudden cessation of Kit’s bellowing. “Ah, we have his attention. What ails you, young sir? You’ve woken the watch and disturbed my lady’s sleep.” “Keep talking,” Sophie said softly. “This is the first time he’s quieted in more than an hour.” Vim’s gaze went to the clock on her mantel. It was a quarter past midnight, meaning Sophie had gotten very little rest. “Give him to me, Sophie. Get off your feet, and I’ll have a talk with My Lord Baby.” She looked reluctant but passed the baby over. When the infant started whimpering, Vim began a circuit of the room. “None of your whining, Kit. Father Christmas will hear of it, and you’ll have a bad reputation from your very first Christmas. Do you know Miss Sophie made Christmas bread today? That’s why the house bore such lovely scents—despite your various efforts to put a different fragrance in the air.” He went on like that, speaking softly, rubbing the child’s back and hoping the slight warmth he’d detected was just a matter of the child’s determined upset, not inchoate sickness. Sophie would fret herself into an early grave if the boy stopped thriving. “Listen,” Vim said, speaking very quietly against the baby’s ear. “You are worrying your mama Sophie. You’re too young to start that nonsense, not even old enough to join the navy. Go to sleep, my man. Sooner rather than later.” The child did not go to sleep. He whimpered and whined, and by two in the morning, his nose was running most unattractively. Sophie would not go to sleep either, and Vim would not leave her alone with the baby. “This is my fault,” Sophie said, her gaze following Vim as he made yet another circuit with the child. “I was the one who had to go to the mews, and I should never have taken Kit with me.” “Nonsense. He loved the outing, and you needed the fresh air.” The baby wasn’t even slurping on his fist, which alarmed Vim more than a possible low fever. And that nose… Vim surreptitiously used a hankie to tend to it, but Sophie got to her feet and came toward them. “He’s ill,” she said, frowning at the child. “He misses his mother and I took him out in the middle of a blizzard and now he’s ill.” Vim put his free arm around her, hating the misery in her tone. “He has a runny nose, Sophie. Nobody died of a runny nose.” Her expression went from wan to stricken. “He could die?” She scooted away from Vim. “This is what people mean when they say somebody took a chill, isn’t it? It starts with congestion, then a fever, then he becomes weak and delirious…” “He’s not weak or delirious, Sophie. Calm down.

In many fields—literature, music, architecture—the label ‘Modern’ stretches back to the early 20th century. Philosophy is odd in starting its Modern period almost 400 years earlier. This oddity is explained in large measure by a radical 16th century shift in our understanding of nature, a shift that also transformed our understanding of knowledge itself. On our Modern side of this line, thinkers as far back as Galileo Galilei (1564–1642) are engaged in research projects recognizably similar to our own. If we look back to the Pre-Modern era, we see something alien: this era features very different ways of thinking about how nature worked, and how it could be known. To sample the strange flavour of pre-Modern thinking, try the following passage from the Renaissance thinker Paracelsus (1493–1541): The whole world surrounds man as a circle surrounds one point. From this it follows that all things are related to this one point, no differently from an apple seed which is surrounded and preserved by the fruit … Everything that astronomical theory has profoundly fathomed by studying the planetary aspects and the stars … can also be applied to the firmament of the body. Thinkers in this tradition took the universe to revolve around humanity, and sought to gain knowledge of nature by finding parallels between us and the heavens, seeing reality as a symbolic work of art composed with us in mind (see Figure 3). By the 16th century, the idea that everything revolved around and reflected humanity was in danger, threatened by a number of unsettling discoveries, not least the proposal, advanced by Nicolaus Copernicus (1473–1543), that the earth was not actually at the centre of the universe. The old tradition struggled against the rise of the new. Faced with the news that Galileo’s telescopes had detected moons orbiting Jupiter, the traditionally minded scholar Francesco Sizzi argued that such observations were obviously mistaken. According to Sizzi, there could not possibly be more than seven ‘roving planets’ (or heavenly bodies other than the stars), given that there are seven holes in an animal’s head (two eyes, two ears, two nostrils and a mouth), seven metals, and seven days in a week. Sizzi didn’t win that battle. It’s not just that we agree with Galileo that there are more than seven things moving around in the solar system. More fundamentally, we have a different way of thinking about nature and knowledge. We no longer expect there to be any special human significance to natural facts (‘Why seven planets as opposed to eight or 15?’) and we think knowledge will be gained by systematic and open-minded observations of nature rather than the sorts of analogies and patterns to which Sizzi appeals. However, the transition into the Modern era was not an easy one. The pattern-oriented ways of thinking characteristic of pre-Modern thought naturally appeal to meaning-hungry creatures like us. These ways of thinking are found in a great variety of cultures: in classical Chinese thought, for example, the five traditional elements (wood, water, fire, earth, and metal) are matched up with the five senses in a similar correspondence between the inner and the outer. As a further attraction, pre-Modern views often fit more smoothly with our everyday sense experience: naively, the earth looks to be stable and fixed while the sun moves across the sky, and it takes some serious discipline to convince oneself that the mathematically more simple models (like the sun-centred model of the solar system) are right.

Lieutenant Jaxon Knight replied, “No sir. D-L1 is the only jumpgate with a pending arrival and it is due in an hour, and it is just some civilian traffic. I'm not detecting them on the hyperNEP relays, and I really doubt they are an hour early.” Captain Devereaux stood up. “Has there been any pirate activity or anything else of note in this sector? Can you get a fix on the fluctuations? How far are they?” Lieutenant Commander Ember Skyrift replied, “It's been quiet, sir, no pirate activity. I can't get a good lock on the flux. The wake is big, at least one large warship. And, sir, it's heading rim-trailward.

dirt lane ran behind these old double lots built for beach cottages early in the last century. Back then not every house had flush toilets. A honey wagon came around at nights to maintain the outhouses. Now transients tracked through the old lanes trash-picking and collecting recyclables from the dumpsters.

Ben started to bark. I don’t think I’ll ever get that image out of my head. She was blown up like a balloon.” “Then she’s been in the water for quite some time,” Smith said. “You said she was next to the barge?” Thompson said. “Can you show us?” Gillian stood up and sat

SOME WOMEN HAVE SAID that Mrs. Pym was never young, that even in her initial stages she was probably an elderly baby. Obviously, such women should drink milk out of saucers; still, it is a fact that Mrs. Pym was somehow stolid, enormously capable, and frequently harsh, even in the early 1920’s when she must have been around thirty. She affected the same ugly tweeds, the same enchantingly insane hats, and the same air of magnificent omnipotence as she does today. But her hair was brown then, with only the faintest touch of her current greyness. Her speech was as biting, and her contempt for authority and inefficiency as ready as on that notable day when she crashed the shocked portals of New Scotland Yard, the first woman ever to hold rank in Central C.I.D., where, in these present jittery times of nuclear fission and H-bombs, she is Mrs. Assistant-Commissioner Pym.

The audience, too, aware of his propensity, were quick to perceive the least deviation from the text; and if he wandered for a moment, which might also be detected by the eye as well as the ear, in some strange contortion of visage, and some ominous flourish of his bow, a gentle and admonitory murmur recalled the musician from his Elysium or his Tartarus to the sober regions of his desk. Then he would start as if from a dream, cast a hurried, frightened, apologetic glance around, and, with a crestfallen, humbled air, draw his rebellious instrument back to the beaten track of the glib monotony. But at home he would make himself amends for this reluctant drudgery. And there, grasping the unhappy violin with ferocious fingers, he would pour forth, often till the morning rose, strange, wild measures that would startle the early fisherman on the shore below with a superstitious awe, and make him cross himself as if mermaid or sprite had wailed no earthly music in his ear.

CALCIUM-SCORE SCREENING HEART SCAN This is a test used to detect calcium deposits found in atherosclerotic plaque in the coronary arteries. Computerized tomography methods, such as this one, are the most effective way to detect early coronary calcification from atherosclerosis (hardening of the arteries), before symptoms develop. The amount of coronary calcium has been recognized as a powerful independent predictor of future heart problems and is useful in making lifestyle changes and guiding preventive care to reduce their risk. The doctor uses the calcium-score screening heart scan to evaluate risk for future coronary artery disease. If calcium is present, the computer will create a calcium "score" that estimates the extent of coronary artery disease based on the number and density of calcified coronary plaques in the coronary arteries. Absence of calcium is considered a "negative" exam. However, there are certain forms of coronary disease, such as "soft plaque" atherosclerosis, that escape detection during this CT scan. It is important to remember that a negative test suggests a low risk, but does not exclude the possibility of a future cardiac event, such as a heart attack. The calcium-score screening heart scan takes only a few minutes to perform and does not need injection of intravenous iodine.

To test this they gave mice a first stroke in motor cortex and then waited a week before beginning retraining. As expected, the mice recovered only minimally because too much time had been allowed to pass before training was initiated. They then gave these same mice a second stroke in an area near to the original stroke, and, not surprisingly, the animals developed an even worse impairment. The surprising result was that with retraining the mice returned to normal levels of performance. In essence a previous stroke was treated with a new stroke. It should be made clear that this experiment was done to prove definitively that there is a sensitive period after stroke that allows training to promote full recovery at the level of impairment. It is clearly not a viable therapeutic option to induce a second stroke in patients after a first stroke. Other means will need to be found to have the same desired effect without causing more damage to the brain. One promising option is to combine drugs, such as the serotonin reuptake inhibitor Fluoxetine (Prozac), with training early after stroke.25 Another is to drastically increase the intensity and dosage of behavioral training that patients receive early after stroke. At the current time in the first weeks after stroke patients spend about 60 percent of their time alone and 85 percent of the time immobile.26 We know from basic science that hundreds, if not thousands, of movement repetitions are needed to induce detectable changes in motor cortex in animal models.27 Current therapy offers only about thirty!28

He taught Bosch early on that in society all victims are not created equal, but to the true detective they must be.

Detective Sherbet loved his boy. Of that there was no doubt. That he had been worried sick that his young son was showing early signs of homosexuality was almost comical. With that said, I had been touched by Sherbet’s ability to come to terms with the concept. If anything, he loved his boy even more.

Ironically, the last aircraft carrier to sink as a result of the Battle of Midway was an American one. By the early afternoon on June 6, there was some optimism about the prospect of saving the Yorktown, as salvage crews had put out the fires and stabilised the vessel using pumps. The Yorktown was also surrounded by 6 protective destroyers as an escort. However, these destroyers failed to detect the Japanese submarine I-168, which crept to within easy torpedo range. In the middle of the afternoon on June 6, the submarine fired four torpedoes, two of which punched through the Yorktown’s hull, causing more extensive flooding. The third hit the destroyer Hammann, sinking the destroyer within three minutes and causing mass casualties. The fourth torpedo missed, and the I168 was chased off by the remaining American destroyers.

Taylor and Fitz sat at a patio table in the back of Las Palmas. The front room was filled with giggling Vanderbilt co-eds and migrant workers on their lunch break, a testament to the quality of the restaurant as well as its reasonable prices. Taylor was nibbling a steak fajita quesadilla, Fitz was plowing through a taco salad. A pitcher of sweet tea separated them. “So what did Price say?” Fitz asked. “He understood, for starters. He’ll fight any disciplinary action taken against Lincoln. So Linc will feel a lot better about that. Poor guy, he was completely rattled. I don’t know if it was the dope or the sheer terror of having to report that he’d been smoking it. Can you imagine Lincoln with a few toots in him?” Fitz laughed. “No. Mr. Fancypants has always struck me as the one scotch before dinner because it looks good, rather than enjoying it type. He isn’t much for losing control.” “Well, that’s to be expected, if you think about his background. Damn, it would be nice to have him back to work this Wolff case. I’ll bet there’s a ton of financial discovery, right up his little computer-literate heart’s alley. Marcus is back tomorrow, right?” Marcus Wade, her youngest detective, had been out for four days doing his in-service training rotation. Without the two detectives, the squad had been too quiet. “He’ll be in bright and early tomorrow. We can get him up to speed with the Wolff case, let him go to town. Media’s having a field day with the 911 tape.

few days earlier, Trump’s team of data scientists, squirreled away in an office down in San Antonio, had delivered a report titled “Predictions: Five Days Out,” which contained stunning news that contradicted the widespread assumption that Clinton would win easily. It was suddenly clear that Comey’s FBI investigation was roiling the electorate. “The last few days have proven to be pivotal in the minds of voters with the recent revelations in reopening the investigation of Secretary Clinton,” the report read. “Early polling numbers show declining support for Clinton, shifting in favor of Mr. Trump.” It added: “This may have a fundamental impact on the results.” The report’s authors further detected

Physiology at MIT recognized that the richness and detail of the collected data opened the feasibility of creating a new generation of monitoring systems to track the physiologic state of the patient, employing the power of modern signal processing, pattern recognition, computational modeling, and knowledge-based clinical reasoning. In the long term, we hoped to design monitoring systems that not only synthesized and reported all relevant measurements to clinicians, but also formed pathophysiologic hypotheses that best explained the observed data. Such systems would permit early detection of complex problems, provide useful guidance on therapeutic interventions, and ultimately lead to improved patient outcomes.

Top Dog Advisor is a website that provides information to dog owners about their best friend. Our primary focus is on food, training, and health. We leave no stone unturned. What is the best dog food? How do I train my puppy? Top Dog Advisor has the answers to all these questions and more. Dogs can be susceptible to disease and early detection is key for a positive outcome. Top Dog Advisor believes that early detection can be achieved by keeping our readers updated.

Dixie shook her head impatiently. “Not a chance, not a ghost of a chance! Our early-warning facilities are geared to detect the approach of missiles hailing from outside our borders, certainly not from Grizzly Gulch, Illinois! Try to imagine the resultant confusion, the bewildering questions—was the missile one of ours—was this an accident—what, where, how, why, whom? And all of this, mind you, with the very nerve center of the country obliterated!. Why, my God, Kirby, it would have been a scene out of a Three Stooges movie—we wouldn’t have known if our asses were punched or bored!

Early in the last century, the philosopher Henri Bergson wanted to awaken his readers to the unfolding of matter in time. He argued that when we imagine living things and inert objects as existing totally in the present moment, having only spatial characteristics, we cannot understand them fully. In his masterpiece Creative Evolution, he used a lump of sugar in a glass of water to illustrate an altered, intuitive perception of matter in its durée, or continuous unfolding. The way the sugar presents itself at any given moment to our senses, he argued, is just a shadow of its full glory; to fully apprehend it, Bergson wrote, “I must wait until the sugar melts.”10 I must wait until the sugar melts. Another way of putting it is that the sugar is not just a lump of chemical. It is or has a story, and stories have beginnings, middles, and ends. Your understanding of the sugar’s story can never be complete until you see how things turn out. When you do that, you apprehend the sugar’s story in a more complete way … and you may even detect that that dissolution of the sugar was already included in its prior dry, crystalline state. It might have even influenced that earlier state in some way. That is the possibility we are going to explore in this book—not for sugar, but for people.11

It has been proven that dogs can detect lung cancer by smelling a patient’s breath, and can even smell early signs of cancer before medical experts can detect them.

As he makes his way toward us, smiling nervously, I notice a slight thoracic scoliosis, a hint of jaundice in his eyes. I’m trying to break the diagnostic habit now that Sasha and I are in our mid-fifties. Friends and acquaintances have begun to be unlucky, and I’ve learned the hard way that detecting illness early puts me in a bind. “You saying I look like shit, Doc?” I’ve been asked, only half in jest. And there was my close friend and tennis partner, Chester, who was treated successfully for a lymphoma I suspected before anyone else. But for reasons I can’t comprehend, our friendship suffered. Chester avoids me now and plays tennis with other people.

Later, in 2006, Congress appropriated funds to improve the CDC’s system for detecting and reporting on novel threats, directing the agency to “establish a near real-time electronic nationwide public health situational awareness capability” to “share data and information to enhance early detection of rapid response to, and management of, potentially catastrophic infectious disease outbreaks”; but the CDC never implemented the called-for changes.

NDTV got an unpleasant surprise when a straight-as-an-arrow Income Tax Officer S K Srivastava, detected large-scale frauds in the accounts of NDTV in 2005 and early 2006. Its larger than law persona notwithstanding; he took up inquiries and investigation in the affairs of NDTV while working as the Additional Director of Income Tax (Inspection) in the Inspection Division of the Central Board of Direct Taxes (the CBDT). He was tasked with the “Preventive Vigilance” functions in the CBDT and the income Tax Dept. NDTV

What happened to you?” “I got mugged.” “Jeez. Looks like more than the average mugging.” “I’ll be all right.” He dropped his gaze to Alex. “I was well taken care of.” They had no longer than a millisecond of eye engagement. Hammond tried to telegraph a warning, but her lawyer nudged her forward into the office. “Well, what now, Detective?” “We’ve got a recording we want your client to hear.” “A recording of what?” “Of an interrogation we conducted early this morning with a man in our own jail.

The law required the CDC to “establish a near real-time electronic nationwide public health situational awareness capability through an interoperable network of systems to share data and information to enhance early detection of rapid response to, and management of, potentially catastrophic infectious disease outbreaks and other public health emergencies that originate domestically or abroad.”30 As Levin observed, “the simplest way to describe the CDC’s response to this binding legal mandate was that it just ignored it. It did nothing.

Two essential principles of investigation came into play here. First, it is important to interview witnesses as soon after an incident as possible, in order to get the freshest possible memories of the events and to lock witnesses into their stories. Second, since guilty parties frequently coerce or persuade their friends to collaborate on a story, persons with potentially probative information are quickly split up and interviewed separately so that they can't agree on a common version of the story. Experienced detectives know that it is difficult to maintain a lie. If you didn't live it, it didn't happen, and therefore the details aren't hardwired into your mind. Liars have a hard time keeping a story straight, which is why subsequent versions are often verbatim recitations of the first telling, with very specific details offered to make the story seem truthful, while a truthful version may vary or be more vague. For this reason, it is important to lock in the details early and then keep pressure on suspected liars to see how they behave when telling their stories and how their stories hold up over time.

Pediatric chiropractors can detect and address these misalignments early on, promoting proper development and reducing the risk of future health complications.

Mostly because, of all the major cancers, colorectal cancer is one of the easiest to detect, with the greatest payoff in terms of risk reduction. It remains one of the top five deadliest cancers in the United States, behind lung (#1) and breast/prostate (#2 for women/men), and just ahead of pancreas (#4) and liver (#5) cancers. Of these five, though, CRC is the one we have the best shot at catching early.

English and half Nigerian, Stacey had never set foot outside the United Kingdom. Her tight black hair was cut short and close to her head following the removal of her last weave. The smooth caramel skin suited the haircut well. Stacey’s work area was organised and clear. Anything not in the labelled trays was stacked in meticulous piles along the top edge of her desk. Not far behind was Detective Sergeant Bryant who mumbled a ‘Morning, Guv,’ as he glanced into The Bowl. His six foot frame looked immaculate, as though he had been dressed for Sunday school by his mother. Immediately the suit jacket landed on the back of his chair. By the end of the day his tie would have dropped a couple of floors, the top button of his shirt would be open and his shirt sleeves would be rolled up just below his elbows. She saw him glance at her desk, seeking evidence of a coffee mug. When he saw that she already had coffee he filled the mug labelled ‘World’s Best Taxi Driver’, a present from his nineteen-year-old daughter. His filing was not a system that anyone else understood but Kim had yet to request any piece of paper that was not in her hands within a few seconds. At the top of his desk was a framed picture of himself and his wife taken at their twenty-fifth wedding anniversary. A picture of his daughter snuggled in his wallet. DS Kevin Dawson, the third member of her team, didn’t keep a photo of anyone special on his desk. Had he wanted to display a picture of the person for whom he felt most affection he would have been greeted by his own likeness throughout his working day. ‘Sorry I’m late, Guv,’ Dawson called as he slid into his seat opposite Wood and completed her team. He wasn’t officially late. The shift didn’t start until eight a.m. but she liked them all in early for a briefing, especially at the beginning of a new case. Kim didn’t like to stick to a roster and people who did lasted a very short time on her team. ‘Hey, Stacey, you gonna get me a coffee or what?’ Dawson asked, checking his mobile phone. ‘Of course, Kev, how’d yer like it: milk, two sugars and in yer lap?’ she asked sweetly, in her strong Black Country accent.

I drove back to Hollywood feeling like a short length of chewed string. It was too early to eat, and too hot. I turned on the fan in my office. It didn't make the air any cooler, just a little more lively.

Imagine for a moment what the brain must do to ignore (and eventually prune) the neurological processes that identify a dangerous mother? It must compartmentalize fear somewhere outside your consciousness so that bonding can happen. Over time, the brain shrinks danger signals, like a mother’s shrill voice or furrowed brow, so you can tolerate her proximity. Pruning alters perception and protects you when you are small and dependent, but over time, your innate ability to detect or discern risky situations is twisted. In this way, neuroception is altered, which is why exposure to early betrayal puts you at a greater risk of further victimization. Maternal abuse is a devastating betrayal because not only do you miss out on essential nurturance, protection, and guidance, but your neuroception and protective instincts are also damaged. Since you are adapted to danger, situations that would frighten a regular person don’t raise a red flag for you. You know how to bond with others who may betray you.

It was eat or be eaten, which meant we couldn’t forget about them for a second. The human nervous system developed as an early-warning animal detection device, scanning 24/7 for any hint of an approaching heartbeat. Animals were simultaneously our dearest friends and our deadliest enemies, and after 300,000 years, you don’t just end a bond like that without paying a price. When we close ourselves off from the natural world, Wilson was convinced, we’re messing with forces we don’t understand. We’re changing our address with no idea where we’re going.

Communication Experiments The intent behind communication experiments was to test the hypothesis that some agency that appeared to exhibit intelligence was responsible for the 20-year history of anomalies on Skinwalker Ranch. Secondly, during the term of the NIDS presence on Skinwalker Ranch (1996–2002), some early success had been achieved with the use of games and puzzles. The NIDS team had found on a couple of occasions that games patterns that had been left in a controlled environment with no humans present would be interfered with and new patterns created that involved moving game components in an apparently non-random manner. Such activity was observed in a small number of cases when interference by humans, animals, seismic effects, or weather had been ruled out. The majority of the communication strategies on Skinwalker Ranch used by BAASS were traditional and involved the initiation of a variety of games, puzzles, and other approaches in order to establish communication. A pre-locked game or puzzle would be set up in a location that would not be disturbed by human or animal. No access to the game was possible without keys that were housed in Las Vegas. The initial configuration of the game would be photographed, then re-photographed again 24 hours later. If any component of the game had moved during the previous 24 hours, the movement would be detectable by comparing the “before” and “after” photographs. The strategy and data from these communication games were described in the 360-page report entitled “Utah Ranch Investigation: August 2009–February 2010” delivered to DIA in April 2010.

Here’s the sequence of epigenetic events in very early development: The male and female pronuclei (from the sperm and the egg respectively) are carrying epigenetic modifications; The epigenetic modifications get taken off (in the immediate post-fertilisation zygote); New epigenetic modifications get put on (as the cells begin to specialise). This is a bit of a simplification. It’s certainly true that researchers can detect huge swathes of DNA demethylation during stage 2 from this list. However, it’s actually more complicated than this, particularly in respect of histone modifications. Whilst some histone modifications are being removed, others are becoming established. At the same time as the repressive DNA methylation is removed, certain histone marks which repress gene expression are also erased. Other histone modifications which increase gene expression may take their place. It’s therefore too naïve to refer to the epigenetic changes as just being about putting on or taking off epigenetic modifications. In reality, the epigenome is being reprogrammed.

Edward J. Ruppelt, who headed the U.S Air Force’s secret investigation of UFOs in the early 1950s, wrote. “The hassle over the word 'proof' boils down to one question: What constitutes proof? Does a UFO have to land at the River Entrance to the Pentagon, near the Joint Chiefs of Staff offices? Or is it proof when a ground radar station detects a UFO, sends a jet to intercept it, the jet pilot sees it, and locks on with his radar, only to have the UFO streak away at a phenomenal speed? Is it proof when a jet pilot fires at a UFO and sticks to his story even under the threat of court-martial? Does this constitute proof?

One exemplar of that pending disruption is teenager Jack Andraka, who at the age of fourteen single-handedly developed an early-stage detection test for pancreatic cancer that costs just three cents. His approach (awaiting peer review) is 26,000 times cheaper, 400 times more sensitive, and 126 times faster than today’s diagnostics. Big Pharma has no idea how to deal with Jack, who is one of many wunderkinds emerging globally, all of them with the potential to disrupt great companies and long-established industries. The Jacks of the world bring exponential

Encountering an early series of consistent instances can implant an erroneous generality in a child's mind. This mental machinery distills and does not evaluate; it cannot detect whether the larger world runs in accordance with the scheme it has drawn forth from the emotional microcosm of a family. Just as grammatical English emerges from our lips automatically, a structured pattern of emotional relatedness emanates from each of us.

Early detection does not equal disease prevention.

Kenzie agreed to meet him at the park in the morning. Early. Linc sat in his car, waiting for her and watching the sun come up. She pulled in less than five minutes later. They ran some laps, and she told him what Jim had said. Then she ran ahead. He lengthened his strides to catch up, concentrating on the running so he could think. She outpaced him several more times. Feeling frisky. She seemed to have bounced back from her near breakdown at the climbing gym over that ugly card. He caught up again and flung himself across an imaginary ribbon. “And the winner is!” “Cheater,” she yelled, laughing. He loped off the track toward the exercise structures and she followed. Linc grabbed the pull-up bar and swung himself up, doing several. “Jim’s not crazy, Kenzie. Five.” The pull-ups hurt his arms, but it felt good. He’d been spending too much time sitting in front of laptops. Kenzie leaned against the metal frame of the structure, looking around absently at the small park. “I guess he was just thinking out loud. I never saw him get that steamed, though.” He let himself down with excruciating slowness and went up again. “Six. You can understand why.” “Yeah, I do.” “Seven.” He went for some fast ones. “Eight. Nine. Ten.” He sucked in a breath, tightening his abs, and let it out with a whoosh. “Going to the media is an idea. I considered it myself. But--eleven--it won’t work for us. Not at this point.” “Don’t forget about Randy Holt. She didn’t want to go public.” “Twelve.” His biceps bulged as he stayed up, swinging a little in midair. He thought he detected a flicker of interest in Kenzie’s eyes. About time. He was killing himself. She swung her arms to warm up. “Are you done showing off?” “Are you impressed yet?” Small smile. Okay, she had a lot on her mind. He wouldn’t push it. Then--Linc almost lost his grip when she walked over and put a hand on his chest. “Don’t forget to breathe,” she said mischievously. Linc gasped. He wasn’t sure whether to drop to the ground and take her in his arms, or lose the challenge. “Thirteen. Fourteen. And…fifteen.” He dropped to the ground with bent knees, more winded than he expected. “Your turn.” Kenzie reached high to grab the bar before he could grab her and did several without breaking a sweat, her ankles crossed. Perfect form. In more ways than one.

• Detect bugs as early as possible, and fix them as soon as they come to light. • Act as though bug-free software was an attainable goal, but tem- per perfectionism with pragmatism. • If you find yourself faced with a poor quality codebase, do the following: – Recognize there is no silver bullet. – Make sure that the basics are in place first. – Separate clean code from unclean, and keep it clean. – Use bug triage to keep on top of your bug database. – Incrementally clean up bad code by adding tests and refac- toring.

By studying the pattern of footsteps, the farmers were able to gain early detection of eight different cow diseases, enabling early treatment and improving the overall health and longevity of the herd. “A little ingenuity can transform even the oldest of industries like farming,” concluded Sirosh. If

One of the reasons people and animals share such a close relationship is that people have always learned important lessons from animals: what to eat, and what not to eat; when it is safe, or when there is danger about. Have you ever walked in a park or forest where there were no birds singing and no small animals to be seen? It's unsettling, isn't it? Where have the birds gone? And why did they leave? Often, animals can warn us of trouble before we are able to detect it for ourselves. Many people have been saved from fires by their pets, who, sensing the danger early, woke their owners and allowed them to get to safety. By carefully watching animals and their behavior, people can learn, and have learned, a great deal about their environment.

Pentagon.Across the Potomac River, the United States Congress was back in session. At the other end of Pennsylvania Avenue, people began to line up for a White House tour. In Sarasota, Florida, President George W. Bush went for an early morning run. For those heading to an airport, weather conditions could not have been better for a safe and pleasant journey.Among the travelers were Mohamed Atta and Abdul Aziz al Omari, who arrived at the airport in Portland, Maine. 1.1 INSIDE THE FOUR FLIGHTS Boarding the Flights Boston:American 11 and United 175. Atta and Omari boarded a 6:00 A.M. flight from Portland to Boston’s Logan International Airport.1 When he checked in for his flight to Boston,Atta was selected by a computerized prescreening system known as CAPPS (Computer Assisted Passenger Prescreening System), created to identify passengers who should be subject to special security measures. Under security rules in place at the time, the only consequence of Atta’s selection by CAPPS was that his checked bags were held off the plane until it was confirmed that he had boarded the aircraft. This did not hinder Atta’s plans.2 Atta and Omari arrived in Boston at 6:45. Seven minutes later,Atta apparently took a call from Marwan al Shehhi, a longtime colleague who was at another terminal at Logan Airport.They spoke for three minutes.3 It would be their final conversation. 1 2 THE 9/11 COMMISSION REPORT Between 6:45 and 7:40,Atta and Omari, along with Satam al Suqami,Wail al Shehri, and Waleed al Shehri, checked in and boarded American Airlines Flight 11, bound for Los Angeles.The flight was scheduled to depart at 7:45.4 In another Logan terminal, Shehhi, joined by Fayez Banihammad, Mohand al Shehri, Ahmed al Ghamdi, and Hamza al Ghamdi, checked in for United Airlines Flight 175,also bound for Los Angeles.A couple of Shehhi’s colleagues were obviously unused to travel;according to the United ticket agent,they had trouble understanding the standard security questions, and she had to go over them slowly until they gave the routine, reassuring answers.5 Their flight was scheduled to depart at 8:00. The security checkpoints through which passengers, including Atta and his colleagues, gained access to the American 11 gate were operated by Globe Security under a contract with American Airlines. In a different terminal, the single checkpoint through which passengers for United 175 passed was controlled by United Airlines, which had contracted with Huntleigh USA to perform the screening.6 In passing through these checkpoints,each of the hijackers would have been screened by a walk-through metal detector calibrated to detect items with at least the metal content of a .22-caliber handgun.Anyone who might have set off that detector would have been screened with a hand wand—a procedure requiring the screener to identify

The trauma of Down's syndrome is that it is present prenatally and can therefore undermine the early stages of bonding. The challenge of autism is that it sets in or is detected in the toddler years, and so transfigures the child to whom parents have already bonded. The shock of schizophrenia is that it manifests in late adolescence or early adulthood, and parents must accept that the child they have known and loved for more than a decade may be irrevocably lost, even as that child looks much the same as ever.

according to this colonel the nastiest form of weaponized pneumonic plague was developed in Russia, employing canisters that released it in a powdered form from cruise missiles. Hard to detect.” Karin’s voice faltered as she spoke. “It’s . . . horrendous what the human race can concoct. In aerosol form pneumonic plague reaches its zenith, the most terrible, easy-to-deploy world killer out there, all down to the contagiousness of the disease, its resistance to dozens of antibiotics and, at least up to early 2000, no vaccine was available to combat the aerosolized form.

The cheery woman was coming toward me from the adjoining yard as if she had been standing at the corner of the house there, waiting. She was maybe five-eight, and dark the way you’re dark when you spend a lot of time in the sun running and working out and playing sports. I made her for her early- to mid-thirties, but the lines around her eyes and mouth were deep. Probably from all the sun. She was wearing designer jeans like the black guy and Reebok court shoes and a loose linen top that she would probably cover with a linen sport coat if it weren’t so hot. Stylish and attractive, even with the Browning 9mm clipped to her right hip. She badged me with an LAPD detective shield as she approached, still cheery with the smile, and I recognized her just before she said, “Mr. Cole, my name is Angela Rossi. The detective in the gray suit would like to ask you a few questions.” She glanced at the guy in the bad suit and I followed her look just as she knew I would, and when I did she stepped close and threw an overhand with a black leather sap, trying for the side of my head. Sucker shot. I picked up her move and tried to twist out of the way, but she was good and fast and I caught most of the sap on my right cheek with a blossom of pain. The guy in the suit yelled, “Hey!” and the black guy grunted, “Shit!” like they were surprised, too. Rossi followed the sap with a hard knee, but it caught me in the thigh instead of the groin, and then the older guy was there, wedging himself between us, forcing her away and saying, “Dammit, Rossi, you want another beef in your file? Is that what you want?

The Game-Changer in Diabetes Management: Continuous Glucose Monitors Continuous Glucose Monitors (CGMs) have revolutionized diabetes management, offering real-time insights into blood sugar levels like never before. In this article, we'll delve into the significance of CGMs, their benefits, and why they are a game-changer for individuals living with diabetes. Understanding Continuous Glucose Monitors Continuous Glucose Monitors are wearable devices that constantly monitor glucose levels in the interstitial fluid, providing users with real-time data on their blood sugar levels. Unlike traditional finger-prick tests, CGMs offer a continuous stream of information, allowing for proactive management of diabetes. Benefits of Continuous Glucose Monitors Real-Time Monitoring: CGMs offer instant feedback on blood sugar levels, enabling users to make informed decisions about their diet, medication, and lifestyle choices. Early Detection of Trends: CGMs track glucose trends over time, allowing users to identify patterns and adjust their management strategies accordingly. Improved Diabetes Management: With continuous monitoring, individuals can better manage their blood sugar levels, reducing the risk of hyperglycemia and hypoglycemia episodes. Enhanced Quality of Life: CGMs provide greater freedom and flexibility, reducing the need for frequent finger pricks and offering peace of mind to individuals and their caregivers. Why CGMs Are a Game-Changer Precision Medicine: Continuous Glucose Monitors enable personalized diabetes management by providing individualized insights into glucose fluctuations and responses to various factors. Empowerment Through Data: CGMs empower users with valuable data, enabling them to take control of their health and make informed decisions in collaboration with healthcare providers. Continuous Innovation: Advancements in CGM technology, such as improved accuracy and connectivity features, continue to enhance the user experience and expand the capabilities of these devices. Integration with Digital Health Ecosystem: CGMs seamlessly integrate with mobile apps and other digital health platforms, facilitating data sharing, remote monitoring, and telehealth consultations. Conclusion Continuous Glucose Monitors represent a significant advancement in diabetes management, offering real-time insights, personalized care, and improved quality of life for individuals living with diabetes. As technology continues to evolve, CGMs will play an increasingly vital role in empowering individuals to live healthier, more active lives while effectively managing their condition.

The vital roles that schema and pattern play in Archaic art can be considered symptoms of a larger Greek demand for regularity and order which extends beyond the realms of representational art into architecture, poetry, and philosophy and beyond the limits of the Archaic period itself. The language of Homer is highly ordered: its formulae were originally patterns for the ear. Hesiod's Theogony imposes patterns on gods and heroes by putting each in his genealogical place, and his Works and Days moves from a particular instance of injustice to universal truths and patterns of human activity. Archaic poetry in general is full of literary schemata or conventions, and Archaic poets express thought and meaning through the harmony of opposites. Archilochos detected a rhysmos (pattern) even in the rise and fall of human fortunes. The philosophers of Miletos attempted to fit nature to preconceived patterns and so to extract order from apparent chaos. Pythagoras (or his followers) ordered the world through number. The urge to impose kosmos (order) on the nature of things is not peculiar to the Archaic mind – in Xenophon's Oikonomikos Sokrates reports that all things, even pots and pans, look more beautiful when they are kept in order, and even the space between them looks beautiful – but is nonetheless particularly characteristic of it.

Third, and perhaps most importantly, we need to try to detect cancer as early as possible so that our treatments can be deployed more effectively. I advocate early, aggressive, and broad screening for my patients—such as colonoscopy (or other colorectal cancer screening) at age forty, as opposed to the standard recommendation of forty-five or fifty—because the evidence is overwhelming that it’s much easier to deal with most cancers in their early stages. I am also cautiously optimistic about pairing these tried-and-true staples of cancer screening with emerging methods, such as “liquid biopsies,” which can detect trace amounts of cancer-cell DNA via a simple blood test.