Deep Brain Stimulation Quotes

More recently, these electrodes have targeted a new area of the brain (called Brodmann’s area number 25) that is often overactive in depressed patients who do not respond to psychotherapy or drugs. Deep brain stimulation has given almost miraculous relief after decades of torment and agony for these long-suffering patients.

Every year, new uses for deep brain stimulation are being found. In fact, nearly all the major disorders of the brain are being reexamined in light of this and other new brain-scanning technologies. This promises to be an exciting new area for diagnosing and even treating illnesses.

As we shall see, listening to stories while looking at pictures stimulates children’s deep brain networks, fostering their optimal cognitive development.

Lithium regulates the proteins that control the body’s inner clock. This clock runs, oddly, on DNA, inside special neurons deep in the brain. Special proteins attach to people’s DNA each morning, and after a fixed time they degrade and fall off. Sunlight resets the proteins over and over, so they hold on much longer. In fact, the proteins fall off only after darkness falls—at which point the brain should “notice” the bare DNA and stop producing stimulants. This process goes awry in manic-depressives because the proteins, despite the lack of sunlight, remain bound fast to their DNA. Their brains don’t realize they should stop revving. Lithium helps cleave the proteins from DNA so people can wind down. Notice that sunlight still trumps lithium during the day and resets the proteins; it’s only when the sunlight goes away at night that lithium helps DNA shake free. Far from being sunshine in a pill, then, lithium acts as “anti-sunlight.” Neurologically, it undoes sunlight and thereby compresses the circadian clock back to twenty-four hours—preventing both the mania bubble from forming and the Black Tuesday crash into depression.

Lithium regulates the proteins that control the body’s inner clock. This clock runs, oddly, on DNA, inside special neurons deep in the brain. Special proteins attach to people’s DNA each morning, and after a fixed time they degrade and fall off. Sunlight resets the proteins over and over, so they hold on much longer. In fact, the proteins fall off only after darkness falls—at which point the brain should “notice” the bare DNA and stop producing stimulants. This process goes awry in manic-depressives because the proteins, despite the lack of sunlight, remain bound fast to their DNA. Their brains don’t realize they should stop revving.

Subject: SELF WORTH (Very Deep!!!) In a brief conversation, a man asked a woman he was pursuing the question: 'What kind of man are you looking for?' She sat quietly for a moment before looking him in the eye & asking, 'Do you really want to know?' Reluctantly, he said, 'Yes. She began to expound, 'As a woman in this day & age, I am in a position to ask a man what can you do for me that I can't do for myself? I pay my own bills. I take care of my household without the help of any man... or woman for that matter. I am in the position to ask, 'What can you bring to the table?' The man looked at her. Clearly he thought that she was referring to money. She quickly corrected his thought & stated, 'I am not referring to money. I need something more. I need a man who is striving for excellence in every aspect of life. He sat back in his chair, folded his arms, & asked her to explain. She said, 'I need someone who is striving for excellence mentally because I need conversation & mental stimulation. I don't need a simple-minded man. I need someone who is striving for excellence spiritually because I don't need to be unequally yoked...believers mixed with unbelievers is a recipe for disaster. I need a man who is striving for excellence financially because I don't need a financial burden. I need someone who is sensitive enough to understand what I go through as a woman, but strong enough to keep me grounded. I need someone who has integrity in dealing with relationships. Lies and game-playing are not my idea of a strong man. I need a man who is family-oriented. One who can be the leader, priest and provider to the lives entrusted to him by God. I need someone whom I can respect. In order to be submissive, I must respect him. I cannot be submissive to a man who isn't taking care of his business. I have no problem being submissive...he just has to be worthy. And by the way, I am not looking for him...He will find me. He will recognize himself in me. Hey may not be able to explain the connection, but he will always be drawn to me. God made woman to be a help-mate for man. I can't help a man if he can't help himself. When she finished her spill, she looked at him. He sat there with a puzzled look on his face. He said, 'You are asking a lot. She replied, "I'm worth a lot". Send this to every woman who's worth a lot.... and every man who has the brains to understand!!

Neural pathways become ingrained, automatic, if they operate only by habit. They are highly attuned to alterations, to novelty. New sights, sounds, languages, tastes, smells stimulate different synapses in the brain, different message routes, different webs of connection, increasing our neuroplasticity. Our brains have evolved to notice differences in our environment: it’s how we’re alerted to predators, to potential danger. To be sensitive to change, then, is to ensure survival. Professor Adam Galinsky, an American social psychologist who has studied the connection between creativity and international travel, says that ‘Foreign experiences increase both cognitive flexibility and depth and integrativeness of thought, the ability to make deep connections between disparate forms.

listening to stories while looking at pictures stimulates children’s deep brain networks, fostering their optimal cognitive development. Further, the companionable experience of shared reading cultivates empathy, dramatically accelerates young children’s language acquisition, and vaults them ahead of their peers when they get to school. The rewards of early reading are astonishingly meaningful: toddlers who have lots of stories read to them turn into children who are more likely to enjoy strong relationships, sharper focus, and greater emotional resilience and self-mastery. The evidence has become so overwhelming that social scientists now consider read-aloud time one of the most important indicators of a child’s prospects in life. It would be a mistake, though, to relegate reading aloud solely to the realm of childhood.

Philosophy is the creative art of cunning 'Demons' -- it is going to fill human brain and heart with doubt in everything. Even the fact that you do really exist in reality, which seems so obvious and undeniable, becomes a matter of doubt. How can you definitely insist that you are not only bodies brain under the stimulation in such a way that some external being(s) -- supernatural or natural -- feed your brain with the illusory ideas that you are real, and perhaps you are sitting in front of the computer, and reading what is written there. And there is no definite fact that this is not the case, but instead, it is very, very difficult to resist the temptation of philosophical thinking in that direction -- therefore, sooner or later you are going to be involved in such kind of 'demonic' activity, if you are really determined to penetrate deep into mind-blowing questions of philosophy.

When applied to the prefrontal lobes, TMS has been shown to enhance the speed and agility of cognitive processing. The TMS bursts are like a localized jolt of caffeine, but nobody knows for sure how the magnets actually do their work.” These experiments hint, but by no means prove, that silencing a part of the left frontotemporal region could initiate some enhanced skills. These skills are a far cry from savant abilities, and we should also be careful to point out that other groups have looked into these experiments, and the results have been inconclusive. More experimental work must be done, so it is still too early to render a final judgment one way or the other. TMS probes are the easiest and most convenient instrument to use for this purpose, since they can selectively silence various parts of the brain at will without relying on brain damage and traumatic accidents. But it should also be noted that TMS probes are still crude, silencing millions of neurons at a time. Magnetic fields, unlike electrical probes, are not precise but spread out over several centimeters. We know that the left anterior temporal and orbitofrontal cortices are damaged in savants and likely responsible, at least in some part, for their unique abilities, but perhaps the specific area that must be dampened is an even smaller subregion. So each jolt of TMS might inadvertently deactivate some of the areas that need to remain intact in order to produce savantlike skills. In the future, with TMS probes we might be able to narrow down the region of the brain involved with eliciting savant skills. Once this region is identified, the next step would be to use highly accurate electrical probes, like those used in deep brain stimulation, to dampen these areas even more precisely. Then, with the push of a button, it might be possible to use these probes to silence this tiny portion of the brain in order to bring out savantlike skills. FORGETTING TO FORGET AND PHOTOGRAPHIC MEMORY Although savant skills may be initiated by some sort of injury to the left brain (leading to right brain compensation), this still does not explain precisely how the right brain can perform these miraculous feats of memory. By what neural mechanism does photographic memory emerge? The answer to this question may determine whether we can become savants. Until recently, it was thought that photographic memory was due to the special ability of certain brains to remember. If so, then it might be difficult for the average person to learn these memory skills, since only exceptional brains are capable of them. But in 2012, a new study showed that precisely the opposite may be true. The key to photographic memory may not be the ability of remarkable brains to learn; on the contrary, it may be their inability to forget. If this is true, then perhaps photographic memory is not such a mysterious thing after all.

Also bearing witness to the unbearable nature of the vulnerability experienced by peer-oriented kids is the preponderance of vulnerability-quelling drugs. Peer-oriented kids will do anything to avoid the human feelings of aloneness, suffering, and pain, and to escape feeling hurt, exposed, alarmed, insecure, inadequate, or self-conscious. The older and more peer-oriented the kids, the more drugs seem to be an inherent part of their lifestyle. Peer orientation creates an appetite for anything that would reduce vulnerability. Drugs are emotional painkillers. And, in another way, they help young people escape from the benumbed state imposed by their defensive emotional detachment. With the shutdown of emotions come boredom and alienation. Drugs provide an artificial stimulation to the emotionally jaded. They heighten sensation and provide a false sense of engagement without incurring the risks of genuine openness. In fact, the same drug can play seemingly opposite functions in an individual. Alcohol and marijuana, for example, can numb or, on the other hand, free the brain and mind from social inhibitions. Other drugs are stimulants — cocaine, amphetamines, and ecstasy; the very name of the latter speaks volumes about exactly what is missing in the psychic life of our emotionally incapacitated young people. The psychological function served by these drugs is often overlooked by well-meaning adults who perceive the problem to be coming from outside the individual, through peer pressure and youth culture mores. It is not just a matter of getting our children to say no. The problem lies much deeper. As long as we do not confront and reverse peer orientation among our children, we are creating an insatiable appetite for these drugs. The affinity for vulnerability-reducing drugs originates from deep within the defended soul. Our children's emotional safety can come only from us: then they will not be driven to escape their feelings and to rely on the anesthetic effects of drugs. Their need to feel alive and excited can and should arise from within themselves, from their own innately limitless capacity to be engaged with the universe. This brings us back to the essential hierarchical nature of attachment. The more the child needs attachment to function, the more important it is that she attaches to those responsible for her. Only then can the vulnerability that is inherent in emotional attachment be endured. Children don't need friends, they need parents, grandparents, adults who will assume the responsibility to hold on to them. The more children are attached to caring adults, the more they are able to interact with peers without being overwhelmed by the vulnerability involved. The less peers matter, the more the vulnerability of peer relationships can be endured. It is exactly those children who don't need friends who are more capable of having friends without losing their ability to feel deeply and vulnerably. But why should we want our children to remain open to their own vulnerability? What is amiss when detachment freezes the emotions in order to protect the child?

The realization that there were electrical pathways connecting the brain to the body wasn’t systematically analyzed until the 1930s, when Dr. Wilder Penfield began working with epilepsy patients, who often suffered from debilitating convulsions and seizures that were potentially life-threatening. For them, the last option was to have brain surgery, which involved removing parts of the skull and exposing the brain. (Since the brain has no pain sensors, a person can be conscious during this entire procedure, so Dr. Penfield used only a local anesthetic during the operation.) Dr. Penfield noticed that when he stimulated certain parts of the cortex with an electrode, different parts of the body would respond. He suddenly realized that he could draw a rough one-to-one correspondence between specific regions of the cortex and the human body. His drawings were so accurate that they are still used today in almost unaltered form. They had an immediate impact on both the scientific community and the general public. In one diagram, you could see which region of the brain roughly controlled which function, and how important each function was. For example, because our hands and mouth are so vital for survival, a considerable amount of brain power is devoted to controlling them, while the sensors in our back hardly register at all. Furthermore, Penfield found that by stimulating parts of the temporal lobe, his patients suddenly relived long-forgotten memories in a crystal-clear fashion. He was shocked when a patient, in the middle of brain surgery, suddenly blurted out, “It was like … standing in the doorway at [my] high school.… I heard my mother talking on the phone, telling my aunt to come over that night.” Penfield realized that he was tapping into memories buried deep inside the brain. When he published his results in 1951, they created another transformation in our understanding of the brain.

Fuck, Ali.” “That’s what we’re doing.” He smiles. “I don’t think I’ll ever tire of you. I don’t know what to do.” That makes the two of us. To muffle his words and my rattled brain, I bend down and kiss him again. It feels so damn good with Ali deep inside of me. I won’t need too much more stimulation to come again. Neither will he. He pushes himself up to meet me. All I can hear is our laboured breaths, and the slapping of our flesh together. Ali soon tenses and thrusts upwards into me again and again with full force, driving the couch across the floor, until he’s spent. I move off him, and wrap my hand around myself. Ali’s zonedout eyes are utterly absorbed by me as Ijerk off; his concentration consumes every inch of me when I give in to pleasuring myself and I come all over his abs. Ali’s grin is precious. “Come here.” We ignore the sticky mess between us. I reach down and let myself be hugged this time while I calm down from the intensity of sex. As I do that, Ali idly strokes my hair and kisses the top of my head. “You’re incredible.” I can say the same about him. Ali and I together feel effortless

The contractile portions of the intrafusal fibers are innervated by motor neurons in the same fashion as are the larger skeletal muscle cells. The intrafusal membrane is contacted by a motor end plate, which stimulates the spindle cell into contracting or fixing its length, or ceases stimulation to allow the cell to be lengthened passively. But the motor neurons which control the intrafusals are altogether separate from the ones which control the skeletal muscles. The skeletal motor neurons are larger in diameter, with their own vertical tracts through the length of the spinal cord, and end their paths near the summit of the brain, in the motor cortex. They are called alpha motor neurons. The motor neurons for the intrafusal fibers, in contrast, are smaller in diameter, have their own discrete pathways up the spinal cord, and end in collections of cell bodies, or ganglia, deep within the brain, in the brain stem. These are called the gamma neurons.

Television's ability to evoke the fear response is especially significant because Americans spend so much of their lives watching TV. An important explanation for why we spend so much time motionless in front of the screen is that television constantly triggers the "orienting response" in our brains. As I noted in the introduction, the purpose of the orienting response is to immediately establish in the present moment whether or not fear is appropriate by determining whether or not the sudden movement that has attracted attention is evidence of a legitimate threat. (The orienting response also serves to immediately focus attention on potential prey or on individuals of the opposite sex). When there is a sudden movement in our field of vision, somewhere deep below the conscious brain a message is sent: LOOK! So we do. When our ancestors saw the leaves move, their emotional response was different from and more subtle than fear. The response might be described as "Red Alert! Pay attention!". Now, television commercials and many action sequences on television routinely activate that orienting reflex once per second. And since we in this country, on average, watch television more than four and a half hours per day, those circuits of the brain are constantly being activated. The constant and repetitive triggering of the orienting response induces a quasi-hypnotic state. It partially immobilizes viewers and creates an addiction to the constant stimulation of two areas of the brain: the amygdala and the hippocampus (part of the brain's memory and contextualizing system). It's almost as though we have a "receptor" for television in our brains.

Although she has a reputation as a serious and hardworking professional in her field of biomedical research, Trisha Pfluger, M.S., PMP, a Northwest Arkansas resident, still thinks of herself as a fun, approachable person. When not working, Trisha Pfluger of Northwest Arkansas takes the time to meditate and hike with her dog on the beautiful trails of Northwest Arkansas (NWA) near her retreat home. Since founding Juno Biomedical in 2014, Trisha Pfluger, a Northwest Arkansas businesswoman, has led the company to great success in developing next generation deep brain stimulation (DBS) technology in close collaboration with a team of experts at the FDA.

By boosting the electrical quality of deep-sleep brainwave activity, the researchers almost doubled the number of facts that individuals were able to recall the following day, relative to those participants who received no stimulation. Applying stimulation during REM sleep, or during wakefulness across the day, did not offer similar memory advantages. Only stimulation during NREM sleep, in synchronous time with the brain’s own slow mantra rhythm, leveraged a memory improvement. Other methods for amplifying the brainwaves of sleep are fast being developed. One technology involves quiet auditory tones being played over speakers next to the sleeper. Like a metronome in rhythmic stride with the individual slow waves, the tick-tock tones are precisely synchronized with the individual’s sleeping brainwaves to help entrain their rhythm and produce even deeper sleep.

Below are just a few of the infinite questions that, if asked with high emotion and a deep desire to seek out constructive answers, will stimulate new thoughts to resolve your job and career challenges. By asking courageous questions, your brain will come up with seemingly miraculous answers so that you’ll better manage negativity and fear. And when you better manage negativity and fear, you’ll be in a much better state of mind to pursue and land your next job. How have others effectively dealt with this problem in the past? How do I turn this problem into an adventure and meet this challenge with a positive outlook? What can I learn from this, and how can I enjoy the process? What resources are available to me in the community that will assist me in getting a new job? What do I need to research to gain better control of my future? Whom can I recruit for my job transition campaign “board of directors” that will advise me and support my efforts in a positive way? How can I be a hero to myself and others by meeting this challenge head-on with confidence and self-respect? Am I spending more time on the solution than on the problem? Am I displaying leadership qualities to the members of my family so they can be proud of me? What do I have to read to make myself a more educated job campaigner? How can I make those I love more comfortable and at ease with my situation? Whom do I have to meet so I can achieve my goals quickly?

The success of the therapy relies on three main factors: the appropriate selection of patients, the accurate placement of the DBS lead in the sensorimotor regions of the target nuclei, and optimal choice of electrical parameters for stimulation.

In Parkinson's disease (PD), the results of dopamine deficiency include increased neuronal activity in the subthalamic nucleus (STN) and globus pallidus internus (GPi), with irregular and bursting neuronal firing patterns. Increased synchrony is found among sensorimotor networks, which may contribute to PD motor signs.

The STN receives excitatory inputs from motor and premotor cortex and exerts a powerful excitatory effect on its target nuclei, GPi, globus pallidus externa (GPe), SNpr, SNpc, and the pedunculopontine nucleus (PPN).1,3–6

Practicing mindful, focused breathing, even for ten minutes a day, reduces stress and promotes relaxation. Slow, deep, rhythmic breathing causes a reflex stimulation of the parasympathetic nervous system, which results in a reduction in the heart rate and relaxation of the muscles. Also, oxygenation of the brain tends to normalize brain function, reducing anxiety and stress levels.

OM CHANTING Various studies have shown that OM chanting deactivates the limbic part of the brain responsible for our basic emotions (fear, pleasure, anger) and our impulses (hunger, sex, dominance and care of offspring). Since the effectiveness of OM chanting is associated with the experience of vibrations around the ears, scientists have suggested that these sensations are transmitted through the auricular branch of the vagus nerve. As the vagus nerve branches off into the inner ear and larynx, controlling the opening and closing of the vocal cords and tone of the sound, it appears that this is stimulated during the vocalization of the O and M sounds. In addition, by performing chanting in exhalation, the vagus nerve is activated in its role as manager of the parasympathetic system. In addition, chanting, by facilitating the lengthening of the exhalation, further amplifies the effect on the parasympathetic system. This is why this practice helps to calm and relax the body and mind. -Find a quiet place to sit comfortably. -A good position is to sit with your legs crossed and your back straight. -Wear comfortable cotton clothes that do not tighten any part of your body. All body channels should be free and comfortable. Place the palm of your right hand (facing upwards) on the palm of your left hand at navel level. Close your eyes for a few minutes and relax your mind and body. Slowly feel the vibrations that occur in every part of your body. When the vibrations become more intense, start breathing deeply. Hold your breath for a second and then slowly exhale. Initially count to 7 as you exhale. This ought to be duplicated thrice. As you exhale the third time, sing "oooooooooo..." Feel the vibrations in your abdomen (and under your chest). After exhaling, relax for 2 seconds. Breathe in again (slow, deep breaths). As you exhale sing "ooooo..." and feel the vibrations in your chest and neck. After exhaling, relax for 2 seconds. Inhale again (long, deep breath). As you exhale, sing "mmmmmmmm...". Feel the vibrations in your head and neck. After exhaling, relax for 2 seconds. Inhale again and as you exhale say "oooommmm..." or "aaauuummm...". About 80% of the sound should be "aaauuu..." and 20% should be "mmmm...". Repeat the previous steps 3 times (you can do it up to 9 times). After the Om meditation, relax and concentrate on your regular breathing for about 5 minutes. TIPS -Wearing white clothes and being in a white environment will improve your experience. But the rule of white is not fundamental. -A good place could be a quiet room or a garden with shade. Your eyes, ears or other sensory organs should not be disturbed. -Do not consume alcohol for at least 8-10 hours before meditation. -It would be better not to eat or drink anything for at least 2 hours before meditation. The body's channels should not be blocked in order to achieve maximum results. This applies especially to the digestive system. -The best times for this meditation are early in the morning or late at night. -For beginners, singing "aum" can cause dizziness. It is recommended to proceed slowly and try to learn one step at a time. In this way you will prepare body and mind for the next step. -It is very important to open your eyes slowly when your breathing has stabilized. -If you cannot sit on the floor, you can try sitting on a bed or a chair. The most important thing is to keep your back straight. -Doing this kind of meditation in a group brings more peace and harmony to all members than doing it alone.

Within an authentic education framework, learners’ individual psychological and neurological characteristics (akin to social-emotional learning aspects) are given consideration and accepted/honoured as they are, promoting inclusive practices. For example, emotional and other high sensitivities commonly found in gifted and creative personnel are not treated as constraints, maladjustments, or something antisocial; rather, they are considered as enriching a neurodiverse society to operate in a more balanced manner. All learners, including those with high developmental potential, get conducive environments to reach higher levels of development, similar to the self-actualised/self-transcended state. An authentic education system sends learners through a lasting deep learning and/or critical thinking experience, which human brains are capable of under conducive teaching-learning environments; human brains are treated as parallel processors that are capable of dealing with multiple inputs and solving complex problems, unlike machines or computers that are good at executing routine steps in reaching specific answers at very high speeds. In effect, in an authentic learning environment, most parts of a human brain (a.k.a. whole brain) including the right hemisphere, are stimulated using appropriate instructions and activities; this contrasts from mainly addressing the left hemisphere in a traditional environment.

In terms of ESP, Rawls and Davis discovered that the “third eye,” or sixth chakra area of the brain, stimulates inner vision or awareness. Subjects experienced an increase in this ability, as well as peace and calm, by holding a magnet in the left palm or on the back of the right hand. In 1976, Davis and Rawls were nominated for a Nobel Prize in medical physics. In summation, the electrical flow in the body is maintained by certain ions, such as sodium, potassium, calcium, and magnesium. Imbalances in these fundamental materials can cause disease—and can occur because of disease. These imbalances will alter the electrical activity of the body and therefore the actual appearance—shape and form—of the various magnetic or auric fields outside of the body. This might explain the ability of certain “auric readers” to use their psychic skills to perceive deep-seated problems in the body even before medical technology can detect them, as well as the reverse ability to heal the aura and therefore, heal the body. The link between the meridians and the electrical system of the body, as Nordenström proposed, also provides an explanation for healing through the meridians and acupoints. The glial cells act as yet another major player in the body’s microcircuit system, receiving information from the magnetic spectrum inside and outside it, thus adding another dimension to Nordenström’s discoveries. Nordenström used his theories to cure cancer, sending electrical charges into a tumor to shrink it. What did Rawls and Davis discover but one of the primary concepts of healing? There is polarity to every aspect of life. Humans are electrical and magnetic, yin and yang, and health is dependent upon maintaining the appropriate balance of each. Humans are L-fields, acted upon by electricity. And humans are T-fields, acted upon by magnetism. Through the bipolarity that is “L,” or electrical, humans generate life, movement, and activity. Through the bipolarity of our “T,” or magnetic self, we attract what we need and what we can become. Humans are composed of the stuff of thought—and matter. FIGURE 3.6 FORMS OF MAGNETISM In his book A Practical Guide to Vibrational Medicine, Dr. Richard Gerber outlines many forms of magnetism.83 Here is a brief description of each, along with a sample of its effects.

The BIRD Method for Making Good Choices  B = Breathe - When faced with a decision, take a slow, deep breath first. This stimulates your reasoning brain! I = Identify - What exactly is the situation? What are your alternatives? Say them aloud. R = Reason - What would happen if you made each option? Would it benefit you or harm you and others? D = Decide - Make the best decision based on your reasoning.

They demonstrated that the elevated emotional states described by mystics weren’t just subjective fantasies; they were grounded in objective molecular interactions that could be measured and quantified. INGREDIENTS OF THE BLISS BRAIN COCKTAIL Research has shown that each one of the seven bliss neurochemicals is associated with meditation. A review and synthesis of the research literature found increases in serotonin, GABA, vasopressin, and melatonin. The dopamine levels of meditators rose by 56%. Cortisol dropped, and norepinephrine declined to levels appropriate to focused attention without anxiety. The rhythms of the brain’s production of beta-endorphins changed. Heightened oxytocin mobilized the synthesis of anandamide in the nucleus accumbens. A number of studies and reviews show that meditation stimulates the production of nitric oxide, providing meditators with the health benefits of better circulation and brain neuroplasticity. Nitric oxide release is closely coupled with anandamide production; thus meditation and other stress-reducing activities may stimulate the synthesis of both together. Anandamide can also improve cognitive function, motivation, learning, and memory, while triggering the growth of neurons in the brain centers that govern those functions. A blissed brain is a learning brain; meditation cements our feel-good experiences into brain hardware through increased neuroplasticity. Anandamide also relieves anxiety and depression while stimulating closeness and connection with others. The scientific literature shows that oxytocin is increased by meditation. As we saw earlier, oxytocin triggers the release of nitric oxide and anandamide, providing the meditator with a trifecta of pleasurable brain chemicals. 5.18. The only way to get all the most pleasurable neurochemicals surging through your brain at one time is the ecstatic flow state found in deep meditation. Each of these neurochemicals is pleasurable in its own right, and you can get them from activities that stimulate their production. These activities might get you one or two but not all seven in one package.

There’s only one activity that stimulates the brain to produce all seven at the same time, and that’s the ecstatic state of flow. The shortest way there is deep, alpha-driven meditation. When you blend all seven into a single cocktail, the result is euphoria. Let’s see: What might a combination of the first letters of each drug look like? Serotonin, Oxytocin, Norepinephrine, Dopamine, Anandamide, Nitric oxide, and Beta-endorphin? Just for fun, let’s combine them, and call our cocktail’s special blend SONDANoBe. This is the magic formula that, produced inside our own bodies in the proper ratios, bathes the brain in the chemicals of ecstasy. GETTING HIGH ON YOUR OWN SUPPLY When I meditate, I can feel the moment when each drug in the cocktail kicks in. First, I use EFT tapping and release any and every negative thought, emotion, and energy. This drops my level of cortisol, along with suppressing the high beta brain waves of stress. I now have a molecular substrate in my brain upon which I can build a deep and focused meditative experience. Next, I close my eyes and focus. Dopamine kicks in as I anticipate the delicious hormone and neurotransmitter drug cocktail I’m about to be rewarded with. The dopaminergic reward system of my brain fires up and the “body learning” of how to meditate—stored in my basal ganglia, which memorize frequently performed actions—comes online. Ingredient one. My mind starts to wander. My email inbox. The morning’s first meeting. The laugh line of the movie I watched last night. An overdue deadline. Damn, I’m way out of the zone already, cortisol rising, and I haven’t been meditating more than 5 minutes. Dopamine brings me back to focus, aided by norepinephrine. I’m motivated. I want Bliss Brain more than I want an endless loop of the Me Show. I return to center. Cortisol drops. Ahhh, I’m back. Norepinephrine stimulates my attention. Ingredient two. Then I realize that my body is uncomfortable. I have a twinge in my right knee. My lower back hurts. My tummy’s rumbling because it’s empty. I consciously shift my wandering mind back into focus. Back in sync, my neurons secrete beta-endorphin, which masks the pain. The discomfort drops away, and being in a body feels wonderful. Ingredient three. I tune in to each of the archetypal strands that guide me. Mother Mary. Kwan Yin. Healing. Strength. Beauty. Wisdom. I imagine myself meditating in a field of a million saints. I’m lost in Bliss Brain, as serotonin, the satisfaction drug, kicks in. Ingredient four. I feel one with the universe. Oxytocin starts to flow, as I bond with everything. Ingredient five. That releases nitric oxide and anandamide. Ingredients six and seven.

One final point: the small plastic tube found around the clavicle of the best-preserved corpse. Analysis had not shown the presence of chemo drugs. Alongside the ME’s hypotheses, the report stated that the sheath might also have served to link fine electrodes implanted in the brain to a subcutaneous stimulator. They called this technique deep brain stimulation, and it was used to treat severe depression, limit tremors from Parkinson’s disease, or suppress Tourette’s. That was a key discovery, since the killer seemed to be interested in his victims’ brains.