Cycling Therapy Quotes

How could I have risked so much for a lost little girl who probably needs as much therapy as I do?" He tilts his head, eyes going unfocused. "Well, that's not possible." He laughs again, but this time it's so self-deprecating it feels like my anger has nowhere to go. "No one needs as much therapy as I do.

We need this help from the outside because we don't know how to to do this for ourselves. We start with a deep deficit—a chasm really—when it comes to understanding and being tolerant of ourselves, and that's even before we go forth to do battle with the rest of the world. As soon as someone judges, criticizes, dismisses, or ignores, the cycle of pain and reactivity ramps up, compounded by shame, remorse, and rejection. The act of validation, simply saying, 'I can see things from your perspective,' can short-circuit that emotional detour.

It takes a cat to heal a woman's wounded heart." I say this knowing it takes a full range of other factors to resolve emotional damage issues and restore personal equilibrium. I've had a heaping share of therapy, familial support, friendships and rescue. What I craved now, however, was the privacy, closeness, and unconditional love of a cat to bring my healing process full cycle. I needed CiCi.

Getting better at relationships does not mean learning how to get the other person to do or be what you want them to be. In couples therapy, you can work on your relationship together. But you can also work on your relationships by understanding your own individual needs and patterns and the cycles you tend to get stuck in.

Another key process in the cycle of suffering is experiential avoidance. It is an immediate consequence of fusing with mental instructions that encourage the suppression, control, or elimination of experiences expected to be distressing.

You do not respond to your critic’s statements of wrongdoing with denial, defensiveness, or countermanipulation with criticisms of your own. Instead, you break the manipulative cycle by actively prompting further criticism about yourself or by prompting more information about statements of “wrongdoing” from the critical person in an unemotional, low-key manner.

Manipulative coping, however, is an unproductive cycle.

Question: What do patients recall when they look back, years later, on their experience in therapy? Answer: Not insight, not the therapist’s interpretations. More often than not, they remember the positive supportive statements of their therapist. I make a point of regularly expressing my positive thoughts and feelings about my patients, along a wide range of attributes—for example, their social skills, intellectual curiosity, warmth, loyalty to their friends, articulateness, courage in facing their inner demons, dedication to change, willingness to self-disclose, loving gentleness with their children, commitment to breaking the cycle of abuse, and decision not to pass on the “hot potato” to the next generation.

Often, women's symptoms are brushed off as the result of depression, anxiety, or the all-purpose favorite: stress. Sometimes, they are attributed to women's normal physiological states and cycles: to menstrual cramps, menopause, or even being a new mom. Sometimes, other aspects of their identity seem to take center stage: fat women report that any ailment is blamed on their weight; trans women find that all their symptoms are attributed to hormone therapy; black women are stereotyped as addicts looking for prescription drugs, their reports of pain doubted entirely. Whatever the particular attribution, there is often the same current of distrust: the sense that women are not very accurate judges of when something is really, truly wrong in their bodies.

The hamster friend said being able to do front rolls didn't make the hamster as good as Bruce Lee, which was not a true statement and not an untrue statement, because the word 'good' is meaningless until defined within a context and a goal, and hamsters when enjoying the company of other hamsters rarely define or think about contexts and goals, because to do so would make them aware of certain things about the universe that would make them feel a kind of emptiness or 'neutrality of emotion' that is usually desirable only in situations where the hamster wants to stop his or her self-perpetuating cycle of negative thinking, in order to fight severe depression or crippling loneliness. In a situation of severe depression or crippling loneliness caused by a period of time of uncontrollable negative thinking this 'kind of emptiness'--effected by an understanding (of the arbitrary nature of the universe) that is attained by thinking comprehensively about context, goals, and meaning--can be used to neutralize the hamster's automatic and self-perpetuating pattern of negative thoughts, at which point the hamster can form new thoughts, that will cause new behaviors, that will cause new patterns of thought, with which the hamster can better function in life and in relationships with other hamsters.

It was haunting to be entangled in this obnoxious cycle. I want to get out of this viciousness. That pizza is staring at me. I think that slice of pie might hurt me. Thirty-five calories for an Oreo cookie; 75caloriesfor a slice of bread; 285 for a slice of pizza; 350for a plate of pasta. You know, maybe I’ll just study the digits of eggs, wheat, vegetables, apples, oranges. Ugh! Stop. It all hurts so much. That’s it. Make it stop. Please, I beg you. Just make it stop. I felt like the walking and living encyclopedia of numbers and digits.

And it’s a new kind of pain; it can’t be managed by the same strategies you’ve been using to manage the pain of the whip. You were good at managing that old kind of pain, and now you have to learn a whole new way to deal with this whole new kind of pain. As one client of “compassionate mind therapy” put it, if they started practicing self-compassion, they “would open up a well of unbearable sadness.”13

The therapist attunes to, empathetically reflects, and clarifies cycles of affect regulation (e.g., numbing flips into rage which dissolves into shame and hiding) and cycles of interactions with others (as I hide, you harangue me and I shut you out more, triggering an increase in your aggression, and so on). The focus here is on how clients are, in the present, actively and most often without awareness, constructing inner emotional and interpersonal interactional realities into

Basics of Good Self-Care Exercise moderately but regularly Eat healthy but delicious meals Regularize your sleep cycle Practice good personal hygiene Don’t drink to excess or abuse drugs Spend some time every day in play Develop recreational outlets that encourage creativity Avoid unstructured time Limit exposure to mass media Distance yourself from destructive situations or people Practice mindfulness meditation, or a walk, or an intimate talk, every day Cultivate your sense of humor Allow yourself to feel pride in your accomplishments Listen to compliments and expressions of affection Avoid depressed self-absorption Build and use a support system Pay more attention to small pleasures and sensations Challenge yourself

Can you sleep-deprive your way out of a depressed episode? Some researchers think that it may be possible. Using a technique called TSD (total sleep deprivation), researchers subjected depressed bipolar patients to three cycles of sleep deprivation, each consisting of a 36-hour period of sleeplessness followed by a 12-hour sleep-in. After the sessions, over half the participants reported feeling less depressed. The trouble is, TSD runs about a 10 percent risk of kicking a bipolar sufferer into hypomania or mania — about the same rate as SSRI antidepressants. In addition, the positive effects of TSD generally wear off as soon as you return to your normal sleep/wake cycle. Researchers continue to study the potential benefits of TSD when used in combination with other therapies, but the only solid conclusion that researchers have reached is that TSD is definitely not something you should try on your own.

Add Healthy Coping Mechanisms Regardless of how much work we do to heal our root issues, we will always need to deal with life, people, our family, assholes, emotions, pain, disappointment, anxiety, depression, loss, grief, and stress. So we need to not only work on the root causes and break the cycle of addiction, but also to replace our crappy coping mechanisms with healthy and constructive ones. Some examples of healthy coping mechanisms are: breathing techniques, spiritual practices, essential oils, chants and sound therapies, supplements, meditations, positive affirmations, and so on. We need to learn how to incorporate these healthy substitutes—not just know what we “should do.” We need to create an existence where we naturally and impulsively reach for something that builds us up or reinforces us or heals us (a poem or mantra, a meditation, a cup of hot water with lemon) instead of something that just takes us down further (a cigarette, a text to an abusive ex-lover, a bottle of wine, a new pair of shoes we can’t afford).

If you're involved in a motorcycle accident, this can result in devastating injuries, permanent disability or perhaps put you on on-going dependency on healthcare care. In that case, it's prudent to make use of Los Angeles motorcycle accident attorneys to assist safeguard your legal rights if you are a victim of a motorcycle accident. How a san diego car accident attorney Aids An experienced attorney will help you, if you're an injured motorcycle rider or your family members in case of a fatal motorcycle accident. Hence, a motorcycle accident attorney assists you secure complete and commensurate compensation because of this of accident damages. In the event you go it alone, an insurance coverage company may possibly take benefit and that's why you'll need to have a legal ally by your side till the case is settled to your satisfaction. If well represented after a motorcycle collision, you may get compensation for: Present and future lost income: If just after motor cycle injury you cannot perform and earn as just before, you deserve compensation for lost income. This also applies for a loved ones that has a lost a bread-winner following a fatal motorcycle crash. Existing and future healthcare costs, rehabilitation and therapy: these consist of any health-related fees incurred because of this of the accident. Loss of capability to take pleasure in life, pain and mental anguish: a motorcycle crash can lessen your good quality of life if you cannot stroll, run, see, hear, drive, or ride any longer. That is why specialists in motor cycle injury law practice will help with correct evaluation of your predicament and exercise a commensurate compensation. As a result, usually do not hesitate to speak to Los Angeles motorcycle accident attorneys in case you are involved in a motor cycle accident. The professionals will help you file a case within a timely fashion also as expedite evaluation and compensation. This could also work in your favor if all parties involved agree to an out-of-court settlement, in which case you incur fewer costs.

It's possible to see how much the brand culture rubs off on even the most sceptical employee. Joanne Ciulla sums up the dangers of these management practices: 'First, scientific management sought to capture the body, then human relations sought to capture the heart, now consultants want tap into the soul... what they offer is therapy and spirituality lite... [which] makes you feel good, but does not address problems of power, conflict and autonomy.'¹0 The greatest success of the employer brand' concept has been to mask the declining power of workers, for whom pay inequality has increased, job security evaporated and pensions are increasingly precarious. Yet employees, seduced by a culture of approachable, friendly managers, told me they didn't need a union - they could always go and talk to their boss. At the same time, workers are encouraged to channel more of their lives through work - not just their time and energy during working hours, but their social life and their volunteering and fundraising. Work is taking on the roles once played by other institutions in our lives, and the potential for abuse is clear. A company designs ever more exacting performance targets, with the tantalising carrot of accolades and pay increases to manipulate ever more feverish commitment. The core workforce finds itself hooked into a self-reinforcing cycle of emotional dependency: the increasing demands of their jobs deprive them of the possibility of developing the relationships and interests which would enable them to break their dependency. The greater the dependency, the greater the fear of going cold turkey - through losing the job or even changing the lifestyle. 'Of all the institutions in society, why let one of the more precarious ones supply our social, spiritual and psychological needs? It doesn't make sense to put such a large portion of our lives into the unsteady hands of employers,' concludes Ciulla. Life is work, work is life for the willing slaves who hand over such large chunks of themselves to their employer in return for the paycheque. The price is heavy in the loss of privacy, the loss of autonomy over the innermost workings of one's emotions, and the compromising of authenticity. The logical conclusion, unless challenged, is capitalism at its most inhuman - the commodification of human beings.

Adults with ADHD as a group have often experienced more than their fair share of disappointments and frustrations associated with the symptoms of ADHD, in many cases not realizing the impact of ADHD has had on them. When you reflect on a history of low grades, forgetting or not keeping promises made to others, repeated exhortations from others about your unfulfilled potential and the need to work harder, you may be left with a self-view that “I’m not good enough,” “I’m lazy,” or “I cannot expect much from myself and neither can anyone else.” The end result of these repeated frustrations can be the erosion of your sense of self, what is often called low self-esteem. These deep-seated, enduring self-views, or “core beliefs” about who you are can be thought of as a lens through which you see yourself, the world, and your place in the world. Adverse developmental experiences associated with ADHD may unfairly color your lens and result in a skewed pessimistic view of yourself, at least in some situations. When facing situations in the here-and-now that activate these negative beliefs, you experience strong emotions, negative thoughts, and a propensity to fall into self-defeating behaviors, most often resignation and escape. These core beliefs might only be activated in limited, specific situations for some people with ADHD; in other cases, these beliefs color one’s perception in most situations. It should be noted that many adults with ADHD, despite feeling flummoxed by their symptoms in many situations, possess a healthy self-view, though there may be many situations that briefly shake their confidence. These core beliefs or “schema” develop over the course of time from childhood through adulthood and reflect our efforts to figure out the “rules for life” (Beck, 1976; Young & Klosko, 1994). They can be thought of as mental categories that let us impose order on the world and make sense of it. Thus, as we grow up and face different situations, people, and challenges, we make sense of our situations and relationships and learn the rubrics for how the world works. The capacity to form schemas and to organize experience in this way is very adaptive. For the most part, these processes help us figure out, adapt to, and navigate through different situations encountered in life. In some cases, people develop beliefs and strategies that help them get through unusually difficult life circumstances, what are sometimes called survival strategies. These old strategies may be left behind as people settle into new, healthier settings and adopt and rely on “healthy rules.” In other cases, however, maladaptive beliefs persist, are not adjusted by later experiences (or difficult circumstances persist), and these schema interfere with efforts to thrive in adulthood. In our work with ADHD adults, particularly for those who were undiagnosed in childhood, we have heard accounts of negative labels or hurtful attributions affixed to past problems that become internalized, toughened, and have had a lasting impact. In many cases, however, many ADHD adults report that they arrived at negative conclusions about themselves based on their experiences (e.g., “None of my friends had to go to summer school.”). Negative schema may lay dormant, akin to a hibernating bear, but are easily reactivated in adulthood when facing similar gaffes or difficulties, including when there is even a hint of possible disappointment or failure. The function of these beliefs is self-protective—shock me once, shame on you; shock me twice, shame on me. However, these maladaptive beliefs insidiously trigger self-defeating behaviors that represent an attempt to cope with situations, but that end up worsening the problem and thereby strengthening the negative belief in a vicious, self-fulfilling cycle. Returning to the invisible fences metaphor, these beliefs keep you stuck in a yard that is too confining in order to avoid possible “shocks.

light therapy has to be done differently than for those at the Stressed level. Rather than first thing in the morning, use thirty minutes of bright overhead light exposure in the early evening—ideally, five hours before your projected bedtime.

Like other chronic diseases, addiction often involves cycles of relapse and remission. But there is help, and there is hope.

The sea can gauge your mood better than a thermometer can gauge your temperature. The sea is a teacher and a doctor. She gives you what she believes you deserve in dosages, prescribed by her liking. What you believe you need for your ailment may be exactly the opposite of what she believes you need. You may believe a slam job trip will fix your problems, yet she may believe a broker is more important to the lesson you are supposed to learn. You’ll find no better therapy when both the patient and doctor are on the same page. I was hopeful we both agreed that a slammer was in order.

Three core areas became the focus: (1) What happened to you? (2) What happened before you? and (3) What happened around you?

Take the Intergenerational ACES Questionnaire.

Take the Intergenerational ACES (Adverse Childhood Experiences) Questionnaire.

Life is like the lunar cycle, sometimes it is full shining, sometimes it is half shining, other times it goes totally dark. The unpredictability of life is what makes life predictable. Sometimes it rains cats and dogs, the next moment sunshine is unavoidable.

The cycle, once started, is unstoppable. My jealousy and insecurity begin to devastate the relationship like a wrecking ball as I helplessly watch the slow-motion collapse of the building.

Cycle towards your goals, Cycle towards the Journey of your Soul, Destination specialised... Journey #Mickeymized!

Now there is no normal process except death which completely clears the brain from all past impressions; and after death, it is impossible to set it going again. Of all normal processes, sleep comes the nearest to a non-pathological clearing. How often we find that the best way to handle a complicated worry or an intellectual muddle is to sleep over it! However, sleep does not clear away the deeper memories, nor indeed is a sufficiently malignant state of worry compatible with an adequate sleep. We are thus often forced to resort to more violent types of intervention in the memory cycle. The more violent of these involve a surgical intervention into the brain, leaving behind it permanent damage, mutilation, and the abridgment of the powers of the victim, as the mammalian central nervous system seems to possess no powers whatever of regeneration. The principal type of surgical intervention which has been practiced is known as prefrontal lobotomy, and consists in the removal or isolation of a portion of the prefrontal lobe of the cortex. It has recently been having a certain vogue, probably not unconnected with the fact that it makes the custodial care of many patients easier. Let me remark in passing that killing them makes their custodial care still easier. However, prefrontal lobotomy does seem to have a genuine effect on malignant worry, not by bringing the patient nearer to a solution of his problems but by damaging or destroying the capacity for maintained worry, known in the terminology of another profession as the conscience. More generally, it appears to limit all aspects of the circulating memory, the ability to keep in mind a situation not actually presented. The various forms of shock treatment—electric, insulin, metrazol—are less drastic methods of doing a very similar thing. They do not destroy brain tissue or at least are not intended to destroy it, but they do have a decidedly damaging effect on the memory. In so far as this concerns the circulating memory, and in so far as this memory is chiefly damaged for the recent period of mental disorder, and is probably scarcely worth preserving anyhow, shock treatment has something definite to recommend it as against lobotomy; but it is not always free from deleterious effects on the permanent memory and the personality. As it stands at present, it is another violent, imperfectly understood, imperfectly controlled method to interrupt a mental vicious circle. This does not prevent its being in many cases the best thing we can do at present.

Exercise: Understanding Your Cycle Make a list of your obsessions, anxieties, and compulsive behaviors. How do they relate to one another? Draw up a diagram showing how your personal OCD cycle works.

During the worst time of Jesse’s cycle, the “worry” region of her brain was overactive, which caused her to become fixated on things, and the judgment and impulse control part of her brain was underactive. The alcohol likely further dropped her ability to control her behavior. That’s why she was so distraught with her husband and why the idea of grabbing the knife wasn’t properly processed and filtered out. During the best time of her cycle, Jesse’s brain was much more balanced. The answer to this woman’s problem was not just anger-management therapy. It was to get her hormonal fluctuations under control. During the days prior to starting your period, estrogen and progesterone levels hit rock bottom. On scans, I see the worry center of the brain (the anterior cingulate gyrus) start to fire up; as a result, women can get stuck on negative thoughts or give in to behaviors they think will make them feel better, such as reaching for wine or cookies.

Venting how you feel may make you look like a fool. And you may get in a cycle of pushing your loved ones away from you. No one wants to be around someone who bursts out with anger. If you’re quick to vent, you miss important information that your emotions have for you. You steamroll right into another gear. Instead, what you need to do is downshift and listen for the real meaning underneath the anger. You may have never heard of emotions as giving you key information. But they’re there, trying to get your attention.

Such then is the nature of quasispecies : the density of the sequence cloud at any point in sequence space is determined by the relative fitness of the sequence; regions of the cloud representing sequences of lesser fitness will be less densely populated and those with higher fitness, most populated. Here lies the most powerful quality of viral quasispecies: the density distribution of fitness variants dictates that sequences are represented at frequencies in relation to their relative fitness. Genomes with lower fitness will replicate poorly, or not at all, and the fittest genomes will replicate most efficiently. It therefore follows that there is a large bias toward the production of well-adapted genotypes: there are more of them, and they undergo most replicative cycles. This can permit viruses to experience evolutionary adaptation at rates that are orders of magnitude higher than those that could be achieved by truly random unbiased mutation. Sequences rapidly condense around the fittest area of the sequence space. Should the environment change, and, therefore, selective pressures change, a quasispecies can opportunistically exploits its inherent adaptive potential. Genotypes rapidly and ever-faster gravitate toward the cloud's new notational center of gravity. Changes in the fitness landscape of the sequence space that is occupied by a quasispecies are the natural consequence of altered selective pressures operating on the virus population. Such alterations may be the consequence of changed immunologic pressures exerted by the host, the application of antiviral drug therapy, or even cross-species transmission requiring the virus to adapt to a new host. Genotypes that once occupied the 'central' space, reserved for the fittest genotypes, are reduced in frequency and now occupy the more sparsely populated fringes of the fitness landscape; the very edge of the sequence cloud if you will. Here too lies an advantage for a quasispecies: it has a memory. The once best-adapted genotypes, now at a fitness disadvantage, can persist in the quasispecies as minor sequence variants. Under circumstances of fluctuating selective pressures, the ability of the population to recall an 'old' genome variant is a great asset. The quasispecies can rapidly respond and adapt by plucking out a preexisting variant and quickly coalescing around it to recreate an optimal fitness landscape.

To get the most out of this chapter, first find where you are on this map of the cancer journey: Critical stress points. When you have just been diagnosed with cancer or learned that your cancer has recurred or is not responding to treatment. Treatment preparation. When you are anticipating surgery, radiation, chemotherapy, or molecular target therapies. Side effect management. When you are undergoing treatment and need ways (instead of or in addition to drugs) to manage its side effects. Post-treatment. When you are adjusting to the end of active treatment, usually after the final chemotherapy cycle. This situation can, perhaps surprisingly, prove quite stressful. Remission maintenance. Although definitely good news, remission introduces its own issues, most notably fear of recurrence. Remission is also when you will be most determined to take back your life from cancer.

Of course, it is painful when your partner verbally attacks you. Recognize that by responding in kind, you are almost guaranteeing more volleys in your direction, the negative cycle will continue, and you will find no peace.

Not unlike alcoholism, the cycle of OCD continues in solitude and isolation … Even in therapy it never occurred to me to talk about plucking out my eyelashes and eyebrows. Not once did I bring it up – not once did it occur to me bring it up, the shame was so deep and ingrained. Fortunately, over the years alcoholism has gotten more and more screen time and does not carry quite the cloak of shame it once did. You won’t necessarily find us shouting it from the rooftops, but then again there are support groups in high schools these days. Hopefully OCD will one day find a similar degree of understanding in the general audience, because that understanding and dialogue are what we need to break not necessarily the cycle of repetitive behavior - because sometimes we can and sometimes we can’t - but to break the cycle of shame. Because I can tell you from experience . . . the shame is a killer.

At stage 1, the relationship begins with passion. You hold your partner in high regard, praise them, give them all your attention and hope or expect them to do the same. You probably,and without realising it, inflate the positives and might feel like they are “the one.” As the relationship progresses to stage 2, you become more sensitive to words and actions that could possibly hold even the slightest hint of negativity. You may fixate on the smallest of things like a late reply to their text or a missed call, and begin to question their motives and interest. This comes from a place of anxiety, a fear of abandonment and low self-worth. The symptoms of BPD will start to flare up and interfere. At stage 3, the relationship can take on a different tone again. You might start testing out your partner,deliberately push them away or behave unacceptably .You might cause arguments for no reason just to see how willing they are to fight for the relationship. Stage 4 rolls around and you will start to distance yourself from the love of your life, letting the relationship spiral downward because at that point, you are convinced that they are going to leave you. This is really painful for you. You don’t want them to leave, and they don’t want to leave you either. When they express confusion, you will hide away your real feelings and pretend that everything is fine. Stage 5 may be where the relationship ends, especially if your partner isn't aware yet that you are Borderline or just what that means ie this is the playing out of symptoms and not what you really want. Borderlines experience intense mood swings, ranging from sadness at the loss of the relationship to anger against the other person. The fear of abandonment becomes a reality and it fuels your emotional lability. There may be attempts by them to resolve things but if the relationship is really over, then we’re at stage 6, where the Borderline might spiral downward and experience a bout of severe depression. They may give into their thoughts of low self-worth and even resort to reckless behaviors and self-harming to seek distraction and relief. If the relationship hasn’t ended, the cycle may start all over again. The occurrence of this cycle and its intensity depends on whether or not you are managing your illness by seeking professional help, and if you have other sources of emotional support. The BPD cycle is not a sure thing to happen for people that have or know someone with BPD, nor is it an official symptom of the condition. However it is really very common and even if not officially a symptom ,it is symptomatic. The idea that people with BPD cannot ‘hold down’ relationships, however, is a misconception and as a matter of fact, many people with BPD do have healthy and successful relationships, especially if they have been in, or are going through therapy. Because of the intensity of their emotions ,Borderlines can be the most loving, caring empathic and fun partners. 6 “SOMEONE…HELP ME, PLEASE.” - DIALECTICAL BEHAVIOR THERAPY “I just got diagnosed.

I mean…yeah, okay? Yeah. But that’s the thing. I still don’t feel…yeah, all of that has changed, but I still feel like, just…hollow. Like nothingness.” “Sucks, huh?” Claudia said. Kaiyo stared at her incredulously. “Kaiyo, I’m sorry, but that’s how this path goes. It’s not an indication that therapy or the medication or the things that you are doing are not working. This is literally how it works.” Kaiyo scrunched up his nose, but Claudia went on. “At this point, we are still stuck in a Catch-22. See, we feel like crap, so we see the world as crap. We see the world as crap, so we feel like crap. We feel like crap, so…well, you get it. So, how the world actually looks is irrelevant at this point. The actual facts aren’t large enough, and your perspective hasn’t cleared enough, to cause a noticeable difference to the cycle of negative thoughts, negative emotions we are stuck in right now.” Kaiyo slumped a little in his seat, but Claudia

Despite the restriction of stem cells to just two regions of the mammalian central nervous system (CNS)—the lateral ventricle linings and the dentate gyrus—it is possible to grow neural stem cells in tissue culture from a much wider range of brain regions than this. The stem cells grow in a form called neurospheres. These are clumps of cells, up to 0.3 mm wide, that grow in suspension culture in a medium containing two specific growth factors (EGF and FGF). The cultures can be initiated from any part of the foetal CNS and often from parts of the adult CNS as well, even regions not thought to undergo continuous renewal. Neurospheres are thought each to contain a few neural stem cells, which are capable of self-renewal, plus a certain number of transit amplifying cells, that have finite division potential. When neurospheres are plated on an adhesive surface in the presence of serum, they will differentiate and form the three cell types normally generated by neuronal stem cells, which are neurons, and two types of glial cells: astrocytes and oligodendrocytes. If neurospheres are dissociated into single cells, a few per cent of these cells can establish new neurospheres, with similar properties to the original. Repeated cycles of dissociation and growth can provide substantial expansion capacity. The phenomenon of neurospheres is an example of the fact that cells may behave in a different manner in tissue culture from in vivo. Neurospheres have created enormous interest because, unlike haematopoietic stem cells, they are expandable in vitro, and because there is a hope that they might be used for cell therapy of the very intractable neurodegenerative diseases involving widespread neuronal death.

Your high arousal also fuels negative and judgmental thinking, which further fuels negative emotional arousal—a vicious cycle.

The borderline symptoms are the core element of what Buddhism describes as dukkha (suffering): endless grasping, all-consuming intolerance, and complete ignorance of how our actions keep us trapped in this endless cycle.

People with self-defeating behaviors can identify and change their negative thought patterns and behaviors with the help of cognitive behavioral therapy (CBT).

While picking the good, we have the best of intentions in mind; say, like using these traits in the best possible way. Over time and circumstances, some of these traits become redundant and over-used. Situations change while traits don’t. This leads to the traits falling behind in the cycle of survival.

In cognitive behavioral therapy we call this defusion. Becoming aware of this difference de-fuses—creates a distance between—the part of you that is hyperreactive to threat and the rational part of you that can notice your thoughts, emotions, and bodily sensations, and learn to override them when necessary.

Make threats instead. Therapy doesn’t suit you.

Syphilis is caused by a spiral bacterium (aka a spirochete) known as Treponema pallidum. The bacterium is usually acquired during sexual contact, whereupon it corkscrews its way across mucous membranes, multiplies in the blood and lymph nodes, and, if a patient is especially unlucky, gets into the central nervous system, including the brain, causing personality change, psychosis, depression, dementia, and death. That’s in the absence of antibiotic treatment, anyway; modern antibiotics cure syphilis easily. But there were no modern antibiotics in 1917, and the early chemical treatment known as Salvarsan (containing arsenic) didn’t work well against late-stage syphilis in the nervous system. Wagner-Juaregg solved that problem after noting that Treponema pallidum didn’t survive in a test tube at temperatures much above 98.6 degrees Fahrenheit. Raise the blood temperature of the infected person a few degrees, he realized, and you might cook the bacterium to death. So he began inoculating patients with Plasmodium vivax. He would allow them to cycle through three or four spikes of fever, delivering potent if not terminal setbacks to the Treponema, and then dose them with quinine, bringing the plasmodium under control. “The effect was remarkable; the downward progression of late-stage syphilis was stopped,” by one account, from the late Robert S. Desowitz, who was a prominent parasitologist himself as well as a lively writer. “Institutions for malaria therapy rapidly proliferated throughout Europe and the technique was taken up in several centers in the United States. In this way, tens of thousands of syphilitics were saved from a sure and agonizing death”—saved by malaria.

But randomized control trials have found that directly observed therapy is no more effective than giving patients their pills to take home in two-week or monthlong cycles, provided the patients are adequately supported. DOTS also failed to address the growing crisis of drug-resistant tuberculosis, and failed to identify many cases of TB because smear microscopy is so much less sensitive than chest X-rays. But even in 2025, DOTS remains standard practice in much of the world.

Personal growth is like doing laundry—just when you think you’re done, there’s another load waiting. But hey, at least you’re getting cleaner with every cycle!

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