Chronic Inflammation Quotes

The panic of altruism: sadness rests inside the body, always, nascent like the inflammation of a chronic disease. Therefore, empathy is not a reaching outward. It is a loop. Because there isn't any separation any more between what you are and what you see.

Chronic rage, by contrast, floods the system with stress hormones long past the allotted time. Over the long term, such a hormonal surplus, whatever may have instigated it, can make us anxious or depressed; suppress immunity; promote inflammation; narrow blood vessels, promoting vascular disease throughout the body;

Chronic inflammation is a superhighway that runs straight to the most deadly diseases out there.... Chronic inflammation comes from how we think, how we feel, how we live.

So many modern diseases, including heart disease, depression, cancer, Alzheimer’s, and all the autoimmune diseases (such as rheumatoid arthritis and lupus), occur in part because our body’s immune systems produce excess chronic inflammation. In chronic inflammation, the immune system stays on too long and may even begin to attack the body’s own tissues, as though they were outside invaders. The causes of chronic inflammation are many, including diet and, of course, the countless chemical toxins that become embedded in the body. Chronically inflamed bodies produce chemicals, called pro-inflammatory cytokines, which contribute to pain and inflammation.

Twenty years of medical research has shown that childhood adversity literally gets under our skin, changing people in ways that can endure in their bodies for decades. It can tip a child’s developmental trajectory and affect physiology. It can trigger chronic inflammation and hormonal changes that can last a lifetime. It can alter the way DNA is read and how cells replicate, and it can dramatically increase the risk for heart disease, stroke, cancer, diabetes—even Alzheimer’s.

We cannot outrun our past trauma. We can’t bury it and think that we will be fine. We cannot skip the essential stage of processing, accepting, and doing the hard, yet necessary trauma recovery work. There’s a body-mind connection. Trauma can manifest itself into chronic physical pain, cancer, inflammation, auto-immune conditions, depression, anxiety, PTSD, Complex PTSD, addictions, and ongoing medical conditions.

although the mechanism isn’t clear yet, strenuous exercise changes the categories of genes that prevent the development of chronic inflammation, which more and more, is believed to be the underlying cause of many chronic conditions.

Many chronic symptoms and health conditions—such as fatigue, sleepiness, mood disorders, insomnia, gastroesophageal reflux disease, lipid disorders, high blood pressure, headaches (including migraines), gas, bloating, irritable bowel syndrome, joint inflammation, acne, and difficulty concentrating, to name a few—will improve on a ketogenic diet. Treating lifestyle conditions with lifestyle change such as this can make us a healthier and less drug-dependent country. – Jackie Eberstein

Foods with similar nutrients can affect hormones and metabolism in profoundly different ways, determining whether we store or burn calories, build fat or muscle, feel hungry or satisfied, struggle with weight or maintain a healthy weight effortlessly, and suffer from or avoid chronic inflammation.

The word “inflammation” comes from the Latin verb “inflammare,” or “to set on fire,

Endo doesn't just affect the pelvic region. The body's response to the inflammation it causes sensitizes the central nervous system, and if you don't know what's going on - as I didn't - this sensitization ***** with your head. If your head's not right, there's a good chance you're in distress. This is where endo crosses the line from a physical ailment to an emotional one too. -- from the forward, written by Bojana Novakovic

Here is a short form list of what is happening to your life: 1. You are practicing hate. 2. You are practicing violent abuse toward your parents and to your own family. 3. The way you treat your parents causes them physical and emotional pain. 4. The way you treat your parents causes them to develop mental diseases such as PTSD, depression, obsessive thoughts, low self esteem, aggressive and self destructive behavior, distrust of entering relationships, isolation, anxiety, panic attacks and obsessive thought of suicide. 5. The way you treat your parents causes them to develop physical illnesses such as chronic toxic stress which leads to inflammation of body organs which leads to heart attacks, arthritis, and irritable bowel syndrome. 6. The way you treat your parents produces feelings of abandonment and ostracism which is experience as physical pain on a

One of the most important medical discoveries in recent years was the realization that inflammation appears to play a role in many of our chronic diseases, including at least eight of our top ten leading causes of death.

and I am convinced that healthy emotional boundaries—such as being clear and vocal about what you will and will not let into your life—are what make relationships functional. Your gut lining is a boundary between you and everything else in the universe that is poised to inundate and overwhelm your biology and generate unrelenting inflammation. Healing and strengthening your gut lining with food—therefore creating and strengthening this critical boundary and reducing intestinal permeability or “leaky gut”—allows you to be selective about what you want to take in from the universe on a material level. You can choose what serves you. I reflect on the fact that many of the problems in society—including violence, mental illness, developmental issues, and pain—start in humans, and humans are made by cells that become dysfunctional largely because of oxidative stress, mitochondrial dysfunction, and chronic inflammation. How miraculous that food can directly combat those things. We can’t have a healthy society without well-functioning humans. We can’t have well-functioning humans without well-functioning cells. And we can’t have well-functioning cells with mitochondrial dysfunction, oxidative stress, chronic inflammation, and cellular and hormone disruption from toxic chemicals in our food. We combat those things through nutrient-dense, unprocessed foods grown in living, thriving soil.

Your waist size is such an important predictor of health because the type of fat that is stored around your waistline—called “visceral fat” or “belly fat”—is related to the release of proteins and hormones that cause inflammation, which can in turn damage your arteries and affect how you metabolize sugars and fats. For this reason, visceral fat is strongly linked to type 2 diabetes, heart disease, stroke, Alzheimer’s, and other chronic diseases. Seeing your waist size come down is a great indicator of improving health.

Neurogenic inflammation is one of the ways that the emotional body declares itself. This form of inflammation could be described as a potential indication of a spiritual wound, or at the very least, a sign of an emotional problem. Although Western doctors are trying to develop medications to address various forms of neurogenic inflammation, such treatment will not likely address underlying emotional problems. Neurogenic inflammation is currently gaining more and more attention, as it appears to be involved in a wide range of health problems (which in some cases are psychosomatic in nature), including asthma, allergic rhinitis, chronic cough, psoriasis, migraine headaches, and fibromyalgia.

The evidence of inflammation in people with ME/CFS is important because the incremental aerobic exercise recommended by the Wessely School and encapsulated in NICE’s Clinical Guideline 53 is contra-indicated in cases of inflamed and damaged tissue and inevitably results in post-exertional relapse with malaise, which is the cardinal symptom of ME/CFS.

Compromised cells respond better than healthy cells to photochemical reactions so that brief treatments with low level light on damaged tissue can induce a complex chain of physiological reactions to enhance wound healing and tissue regeneration, reduce acute inflammation, treat chronic pain and even to make our skin look younger and more vibrant”[45]

I reflect on the fact that many of the problems in society—including violence, mental illness, developmental issues, and pain—start in humans, and humans are made by cells that become dysfunctional largely because of oxidative stress, mitochondrial dysfunction, and chronic inflammation. How miraculous that food can directly combat those things. We can’t have a healthy society without well-functioning humans. We can’t have well-functioning humans without well-functioning cells. And we can’t have well-functioning cells with mitochondrial dysfunction, oxidative stress, chronic inflammation, and cellular and hormone disruption from toxic chemicals in our food. We combat those things through nutrient-dense, unprocessed foods grown

Healing Foods When you’re looking to boost the immune system and support the reproductive system, the best foods to concentrate on are wild blueberries, sesame tahini, avocados, black beans, asparagus, apples, spinach, black grapes, and cucumbers. They’ll help by variously providing antioxidants, preventing hot flashes, providing critical nutrients to fortify vital organs, reducing inflammation, and keeping hormone levels balanced. Herbs and Supplements to Address General Symptoms Silver hydrosol: kills viruses, bacteria, and other microbes on contact and supports the immune system. Zinc: kills viruses, boosts the immune system, and helps protect the endocrine system. Licorice root: aids the adrenal glands and helps balance the body’s levels of cortisol and cortisone. L-lysine: impairs the ability of virus cells to move and reproduce. Vitamin B12 (as methylcobalamin and/or adenosylcobalamin): strengthens the central nervous system. Nascent iodine: stabilizes and strengthens the thyroid and the rest of the endocrine system. Ashwagandha: fortifies the adrenal glands and helps balance the production of cortisol.

On the other hand, when you mismanage your genes with poor dietary habits or chronic exercise patterns, you will likely suffer from obesity (through the chronic overproduction of insulin), fatigue (poor sleep habits disturbing optimal hormone balance), and systemic inflammation and burnout (chronic production of “fight or flight” hormones in the face of unrelenting environmental stressors).

you’re over fifty or have dealt with serious health problems in the past, find a local ozone doctor and get IV treatments when they are affordable for you. At worst, your mitochondria will become better. At best, the ozone will knock out other unpleasant stuff growing in your body that you don’t even know about. •​If you have arthritis or sore joints that don’t get better, consider prolozone injections into the impacted joint to speed healing dramatically. •​If you’re having dental work done, look for a dentist who uses ozone gas to sterilize the teeth before treatments. This can help you avoid chronic inflammation and its corresponding aging. •​Up your NAD+ with supplements or IV treatments to boost mitochondrial function at any age. If you don’t want to try either of these, you can increase your NAD+ levels through cyclical ketosis, intermittent fasting, and/or calorie restriction.

Do we stop needing our mom? Not at all. Over time, without maternal comfort, we do learn to bury the need. But the need doesn’t go away. Unmet needs for maternal nurturance and protection fester like an angry infection. The body holds the memory of emotional pain and, over time, may generate chronic distress and insecurity. When distress is the norm, it becomes toxic. Toxic stress creates physiological inflammation, weakening the immune system.

Exposure to nature not only helps with creativity, but it may also lower levels of Interleukin-6 (IL-6), a molecule associated with inflammation in the body. Lower levels of IL-6 can prevent the harmful, chronic type of inflammation that often sidelines serious athletes. According to a study published in the journal Emotion, more than any other positive feeling, awe, an emotion commonly brought about by nature, is linked to lower levels of IL-6.

the following supplements are recommended specifically for MS. They’ll help reduce pain and protect your myelin sheath as you heal from EBV: EPA & DHA (eicosapentaenoic acid and docosahexaenoic acid): omega-3 fats to help protect and fortify the myelin nerve sheath. Be sure to buy a plant-based (not fish-based) version. L-glutamine: amino acid that removes toxins such as MSG from the brain and protects neurons. Lion’s mane: medicinal mushroom that helps protect the myelin sheath and support neuron function. ALA (alpha lipoic acid): helps repair damaged neurons and neurotransmitters. Also helps mend the myelin nerve sheath. Monolaurin: fatty acid that kills virus cells, bacteria cells, and other bad microbes (e.g., mold) in the brain. Curcumin: component of turmeric that reduces inflammation of the central nervous system and relieves pain. Barley grass juice extract powder: contains micronutrients that feed the central nervous system. Also helps feed brain tissue, neurons, and the myelin nerve sheath.

Any respiratory viral infection, any inflammation in the brain or CNS—especially encephalitis and meningitis, fatigue and weakness, especially after long illness or in chronic infections, poor mitochondrial function, chronic wasting, unproductive cough from no known cause, joint inflammation, mental fog and confusion, low libido, lung infections, kidney infections, thick mucus in the lungs that will not move, immune dysregulation, dizziness, tinnitus, nocturia, cancer. It is especially effective for mycoplasma infections.

It’s critical to know that our bodies don’t attack themselves. Here is the truth: the inflammation in the joints is there to protect you from attack by a particularly common virus. Your body is working hard to stop pathogens from digging deeper into the joints and the tissue around them. When the inflammation becomes long-term and chronic, that’s when it becomes the problem known as RA—but it is still your body working to ward off viral damage. Doctors also believe that there’s no way to heal from rheumatoid arthritis. They’re mistaken about that, too.

For almost the entirety of our species’ existence on this planet, grains have been unavailable as a food source, as they are toxic to humans when eaten raw. The discovery of methods for rendering them edible was the spark that ignited the agricultural revolution. Grains are nutrient poor and contain substances that block nutrient absorption (phytates), disrupt the intestinal lining (lectins), lead to life-threatening gastrointestinal illness in vulnerable populations, and may be a critical factor in the pathogenesis of a whole host of chronic diseases (gluten).

Harm reduction is often perceived as being inimical to the ultimate purpose of “curing” addiction—that is, of helping addicts transcend their habits and to heal. People regard it as “coddling” addicts, as enabling them to continue their destructive ways. It’s also considered to be the opposite of abstinence, which many regard as the only legitimate goal of addiction treatment. Such a distinction is artificial. The issue in medical practice is always how best to help a patient. If a cure is possible and probable without doing greater harm, then cure is the objective. When it isn’t — and in most chronic medical conditions cure is not the expected outcome — the physician’s role is to help the patient with the symptoms and to reduce the harm done by the disease process. In rheumatoid arthritis, for example, one aims to prevent joint inflammation and bone destruction and, in all events, to reduce pain. In incurable cancers we aim to prolong life, if that can be achieved without a loss of life quality, and also to control symptoms. In other words, harm reduction means making the lives of afflicted human beings more bearable, more worth living. That is also the goal of harm reduction in the context of addiction. Although hardcore drug addiction is much more than a disease, the harm reduction model is essential to its treatment. Given our lack of a systematic, evidencebased approach to addiction, in many cases it’s futile to dream of a cure. So long as society ostracizes the addict and the legal system does everything it can to heighten the drug problem, the welfare and medical systems can aim only to mitigate some of its effects. Sad to say, in our context harm reduction means reducing not only the harm caused by the disease of addiction, but also the harm caused by the social assault on drug addicts.

Step out barefoot and notice that your mind starts to quiet and you feel more present in your body. Walk on the Earth as though each step is a prayer. Studies have shown that earthing, contacting the earth directly with your feet—in the soil, grass, sand, moss, anything—can help reduce inflammation and chronic pain, reduce stress, improve energy, and improve sleep. Earthing is a cure-all. The two hundred thousand nerve endings on the sole of each foot pick up the electrons transferred from the earth. Walking barefoot will calm your nervous system and help your body return to an optimal electrical state, from which you’re better able to self-regulate and self-heal.

Vitamin D3 boasts a strong safety profile, along with broad and deep evidence that links it to brain, metabolic, cardiovascular, muscle, bone, lung, and immune health. New and emerging research suggests that vitamin D supplements may also slow down our epigenetic/biological aging.29, 30 2. Omega-3 fish oil: Over the last thirty years or so, the typical Western diet has added more and more pro-inflammatory omega-6 polyunsaturated fatty acids versus anti-inflammatory omega-3 PUFAs. Over the same period, we’ve seen an associated rise in chronic inflammatory diseases, including obesity, cardiovascular disease, rheumatoid arthritis, and Alzheimer’s disease. 31 Rich in omega-3s, fish oil is another incredibly versatile nutraceutical tool with multi-pronged benefits from head to toe. By restoring a healthier PUFA ratio, it especially helps your brain and heart. Regular consumption of fatty fish like salmon has been linked to a lower risk of congestive heart failure, coronary heart disease, sudden cardiac death, and stroke.32 In an observational study, omega-3 fish oil supplementation was also associated with a slower biological clock.33 3. Magnesium deficiency affects more than 45 percent of the U.S. population. Supplements can help us maintain brain and cardiovascular health, normal blood pressure, and healthy blood sugar metabolism. They may also reduce inflammation and help activate our vitamin D. 4. Vitamin K1/K2 supports blood clotting, heart/ blood vessel health, and bone health.34 5. Choline supplements with brain bioavailability, such as CDP-Choline, citicoline, or alpha-GPC, can boost your body’s storehouse of the neurotransmitter acetylcholine and possibly support liver and brain function, while protecting it from age-related insults.35 6. Creatine: This one may surprise you, since it’s often associated with serious athletes and fitness buffs. But according to Dr. Lopez, it’s “a bona fide arrow in my longevity nutraceutical quiver for most individuals, and especially older adults.” As a coauthor of a 2017 paper by the International Society for Sports Nutrition, Dr. Lopez, along with contributors, stated that creatine not only enhances recovery, muscle mass, and strength in connection with exercise, but also protects against age-related muscle loss and various forms of brain injury.36 There’s even some evidence that creatine may boost our immune function and fat and carbohydrate metabolism. Generally well tolerated, creatine has a strong safety profile at a daily dose of three to five grams.37 7.

Dr. Lydia Ciarallo in the Department of Pediatrics, Brown University School of Medicine, treated thirty-one asthma patients ages six to eighteen who were deteriorating on conventional treatments. One group was given magnesium sulfate and another group was given saline solution, both intravenously. At fifty minutes the magnesium group had a significantly greater percentage of improvement in lung function, and more magnesium patients than placebo patients were discharged from the emergency department and did not need hospitalization.4 Another study showed a correlation between intracellular magnesium levels and airway spasm. The investigators found that patients who had low cellular magnesium levels had increased bronchial spasm. This finding confirmed not only that magnesium was useful in the treatment of asthma by dilating the bronchial tubes but that lack of magnesium was probably a cause of this condition.5 A team of researchers identified magnesium deficiency as surprisingly common, finding it in 65 percent of an intensive-care population of asthmatics and in 11 percent of an outpatient asthma population. They supported the use of magnesium to help prevent asthma attacks. Magnesium has several antiasthmatic actions. As a calcium antagonist, it relaxes airways and smooth muscles and dilates the lungs. It also reduces airway inflammation, inhibits chemicals that cause spasm, and increases anti-inflammatory substances such as nitric oxide.6 The same study established that a lower dietary magnesium intake was associated with impaired lung function, bronchial hyperreactivity, and an increased risk of wheezing. The study included 2,633 randomly selected adults ages eighteen to seventy. Dietary magnesium intake was calculated by a food frequency questionnaire, and lung function and allergic tendency were evaluated. The investigators concluded that low magnesium intake may be involved in the development of both asthma and chronic obstructive airway disease.

Eggs and Nightshades You may improve your results by restricting eggs and nightshades, too. Egg whites contain proteins that can indirectly increase immune activity—a contributing factor in immune-mediated diseases. Nightshades are a group of plants that contain compounds that promote gut irritability, inflammation, joint pain and/or stiffness in sensitive individuals. Nightshades include potatoes (all varieties except sweet potatoes or yams), tomatoes, all sweet and hot peppers, eggplant, tomatillos, tamarios, pepinos, and spices like cayenne, chili powder, curry powder, paprika, pimento, and red pepper flakes. These two groups are the most commonly problematic in those with autoimmune conditions, chronic pain, and other immune-mediated medical conditions, so consider leaving these off your Whole30 if this is your context.

Chronic inflammation is at the root of nearly all “non-communicable” diseases, i.e. diseases that aren’t caused by infectious bacteria or viruses.

imagine that your DNA is like a piano buried deep in your cells. The keys on the piano are your genes, which can be played in a variety of ways. Some keys will never be pressed. Others will be struck frequently and in steady combinations. Part of what distinguishes me from you and you from everyone else in the world is how these keys are pressed. That’s gene expression. It’s the genetic recital within your cells that plays a role in forming how your body and mind work. Our inner voice, it turns out, likes to tickle our genetic ivories. The way we talk to ourselves can influence which keys get played. The UCLA professor of medicine Steve Cole has spent his career studying how nature and nurture collide in our cells. Over the course of numerous studies he and his colleagues discovered that experiencing chatter-fueled chronic threat influences how our genes are expressed. When our internal conversations activate our threat system frequently over time, they send messages to our cells that trigger the expression of inflammation genes, which are meant to protect us in the short term but cause harm in the long term. At the same time, the cells carrying out normal daily functions, like warding off viral pathogens, are suppressed, opening the way for illnesses and infections. Cole calls this effect of chatter “death at the molecular level.

experiencing occasional oxalate-related aches and pains somewhere in your body. Do you tend to get a stiff neck? In those of us with dietary oxalate overload, pain, knots, or stiffness in the top of the shoulders or in the upper or lower back are typical. Some people experience chronic or intermittent joint inflammation, gout, arthritis, carpal tunnel syndrome, or a more generalized

A full spectrum of products exploit the disruptions of modern life to help us cope with this stress, to make us temporarily less unhappy—and to hook us with a promised return to some imagined state of bliss. The physical environment drives us, through anxiety and opportunity, to the kinds of behaviors that generate more inflammation: overeating, drug use, and self-isolation.118 Chronic stress makes the body vulnerable to addiction,119 increasing levels of emotional stress cause decreased impulse control,120 and the more chronic the stress becomes, the more maladaptive the behavior becomes.121 Chronic stress dampens activity in the prefrontal cortex—the part of the brain responsible for rational decision making and self-control—and heightens activity in the limbic system, which includes the amygdala, an ancient center of the brain that guides impulsive behavior.122 Global industries intuitively understand this connection between the endocrine and nervous systems, encouraging addiction and overconsumption as a path to happiness, a dynamic that David Courtwright calls “limbic capitalism.”123 As Facebook cofounder Sean Parker explained, social media are engineered to hijack our need for social connection, offering “a little dopamine hit” to the reward centers of the brain through likes and retweets and views.124 This is not exactly an accurate description of the complex neurobiology at play, but it is a fair assessment of how Facebook keeps us coming back for more.125

keeping a watchful eye for things like elevated uric acid, elevated homocysteine, chronic inflammation, and even mildly elevated ALT liver enzymes. Lipoproteins, which we will discuss in detail in the next chapter, are also important, especially triglycerides; I watch the ratio of triglycerides to HDL cholesterol (it should be less than 2:1 or better yet, less than 1:1), as well as levels of VLDL, a lipoprotein that carries triglycerides

Chronic inflammation, even if relatively mild, is an enemy of the brain.

Most people, including their physicians, simply accept that diarrhea, constipation, gastritis, bloating, abdominal discomfort/pain, inflammatory bowel syndromes, or almost any other gastrointestinal condition is largely inevitable and typically occurring for seemingly no clear-cut reason, or just the inevitable consequence of growing older. The standard therapeutic goal aims to lessen the gut-related symptoms as best as possible with a variety of prescription and over-the-counter agents. Similarly, there is virtually no awareness that CPC sets the stage for the inflammation causing and sustaining some gastrointestinal cancers, even though chronic inflammation in the gut is recognized as an important factor in the development of cancers there.

At the most basic level, scientists are discovering that nearly all of the chronic diseases that cause so much suffering and are steadily driving up the cost of health care all share mitochondrial dysfunction, excessive inflammation, high cortisol levels, and other markers of broken biochemistry. In a very real sense, we all have the same disease because all diseases begin with broken, incorrect biochemistry and disordered communication within and between our cells. For health to return, the chemistry must revert to normal, and communication within and between our cells must be restored. This is true for every disease.

Because many MCAD patients suffer from progressive (and likely MCAD-driven) build-up of cholesterol-laden plaque in the arteries called atherosclerosis, it’s not surprising that many such patients come to be on simvastatin or one of its sister drugs (e.g., lovastatin or atorvastatin).  Interestingly, more recently it has been discovered that these “statin” drugs cause a mild general reduction in inflammation in the body, though how they do so remains a mystery. Singulair

is as if the body’s chronic underlying state of inflammation were a major determining factor of health.

Cole and others have found that a similar set of inflammation genes are expressed more strongly among people who experience chronic threat, regardless of whether those feelings emerge from feeling lonely or dealing with the stress of poverty or the diagnoses of disease. This happens because our cells interpret the experience of chronic psychological threat as a viscerally hostile situation akin to being physically attacked. When our internal conversations activate our threat system frequently over time, they send messages to our cells that trigger the expression of inflammation genes, which are meant to protect us in the short term but cause harm in the long term. At the same time, the cells carrying out normal daily functions, like warding off viral pathogens, are suppressed, opening the way for illnesses and infections. Cole calls this effect of chatter “death at the molecular level.

It's called; “Grounding or ‘Earthing,” when you walk on the ground, placing your feet directly on the ground without shoes or socks, the earth has an intense negative charge carried by the Earth. This charge is rich in electrons the scientists say. The earth and its soil are full of antioxidants and free radical destroying electrons. By walking barefoot, one allows the earth to protect them against chronic stress, inflammation, pain, poor sleep, blood sugar, and many common health disorders, including cardiovascular disease." “It is believed that all disease begins with inflammation, this is one easy and comfortable way of fighting off the illness associated with age, weight and stress. Kick off your shoes sometimes, it’s very calming

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The most common source of the chronic inflammation we see today is the foods we eat, namely sugar, and foods that turn into sugar, namely processed, refined carbohydrates.

EMF’D.

Trading reproduction for repair, the sirtuins order our bodies to “buckle down” in times of stress and protect us against the major diseases of aging: diabetes and heart disease, Alzheimer’s disease and osteoporosis, even cancer. They mute the chronic, overactive inflammation that drives diseases such as atherosclerosis, metabolic disorders, ulcerative colitis, arthritis, and asthma. They prevent cell death and boost mitochondria, the power packs of the cell. They go to battle with muscle wasting, osteoporosis, and macular degeneration. In studies on mice, activating the sirtuins can improve DNA repair, boost memory, increase exercise endurance, and help the mice stay thin, regardless of what they eat. These are not wild guesses as to their power; scientists have established all of this in peer-reviewed studies published in journals such as Nature, Cell, and Science.

Furthermore, consumption of refined sugar increases inflammation. People with Parkinson’s are in a state of chronic inflammation, and we need to reduce or eliminate any food or activity that exacerbates that state.

Red: Most yang, warm, and stimulating. Produces heat. Stimulates vital energy and circulation of the blood. Stimulates sensory nervous systems and energizes the five basic senses. Stimulates the healing of wounds without pus. Used in treatment of chronic infections. Too much red leads to anger and hyperactivity. Orange: Gentle yang, tonifies. Stimulates appetite, relieves cramps and spasms, increases blood pressure, induces vomiting, relieves gas, builds bones. When used with blue, regulates the endocrine system. Stimulates joy, optimism, and enthusiasm. Yellow: Yang, and the brightest of all colors. Strengthens motor nervous system and metabolism, and aids conditions of the glandular, lymphatic, and digestive systems. Stimulates intellectual functions; boosts cheerfulness and confidence. Green: Neutral yin. Slightly cooling. Treats conditions of the lungs, eyes, diabetes, musculoskeletal and inflammatory joint problems, and ulcers. Is antibacterial and aids in detoxification. Calms, soothes, and balances. Blue: Yin or cool. Relaxes body and mind, reduces fever, congestion, itching, irritation, and pain. Treats high blood pressure, burns, inflammations with pus and diseases involving heat. Contracts tissues and muscles. Calms and tranquilizes when used on the pituitary and pineal acupoints. Helpful for insomnia, phobias, and endocrine imbalances. Not indicated for depression as it is a melancholy color. Violet: Most yin color. Aids the spleen, reduces irritability, and balances the right brain. When combined with yellow, increases lymph production, controls hunger, and balances the nervous system. Acts on the unconscious.35 Complementary Colors The complementary color pairs are: red-green, orange-blue, and yellow-violet. Together, these colors balance yin and yang. For example, red might stimulate the blood and improve circulation while green calms conditions creating stress. Blue might assuage pain while orange lifts fear or depression causing tension. Yellow will strengthen the nervous system while violet calms it with a meditative state.

Beans contain flavonoids and flavonals, which are potent antioxidants. They soak up oxygen radicals and protect your body against oxidative stress and chronic inflammation. Their antioxidant activities are 50 times greater than vitamin E. They are also among the richest food sources of saponins, chemicals that help prevent undesirable genetic mutations.

Eating spices like turmeric (which directly minimize chronic inflammation) or cruciferous vegetables (which directly minimize oxidative stress) are two examples of ways that food can functionally signal for Good Energy.

Sarcopenia can be accelerated by bed rest, immobility and muscle disuse, chronic inflammation, hormone imbalance, low protein intake, many commonly used prescription drugs (such as statins, and those used for blood sugar and blood pressure control) and over-the-counter drugs such as Ibuprofen. Excess body fat can predispose someone to sarcopenia. (Sarcopenia associated with excess body fat is called “sarcopenic overfat.”)

I monitor several biomarkers related to metabolism, keeping a watchful eye for things like elevated uric acid, elevated homocysteine, chronic inflammation, and even mildly elevated ALT liver enzymes. Lipoproteins, which we will discuss in detail in the next chapter, are also important, especially triglycerides; I watch the ratio of triglycerides to HDL cholesterol (it should be less than 2:1 or better yet, less than 1:1), as well as levels of VLDL, a lipoprotein that carries triglycerides—all of which may show up many years before a patient would meet the textbook definition of metabolic syndrome. These biomarkers help give us a clearer picture of a patient’s overall metabolic health than HbA1c, which is not

acute inflammation, subacute inflammation, and chronic inflammation.

Subacute inflammation is the transition period between acute and chronic inflammation.

Chronic inflammation

Chronic inflammation is low-grade inflammation that lasts for several months or longer—years in some cases.

The inflammation theory of disease states that chronic inflammation is the underlying cause of or main expediting factor in most common diseases, including heart disease, cancer, diabetes, arthritis, and Alzheimer’s.43

The combination of too many free radicals, oxidative stress, and glycation leads to a generalized state of inflammation in the body. Inflammation is a protective measure; it’s the result of the body trying to defend against invaders. But chronic inflammation is harmful because it turns against our own body. From the outside, you might see redness and swelling, and on the inside, tissues and organs are slowly getting damaged. Inflammation can also be driven up by alcohol, smoking, stress, leaky gut syndrome, and substances released by body fat. Chronic inflammation is the source of most chronic illnesses, such as stroke, chronic respiratory diseases, heart disorders, liver disease, obesity, and diabetes. The World Health Organization calls inflammation-based diseases “the greatest threat to human health.” Worldwide, three out of five people will die of an inflammation-based disease. The good news is, a diet that reduces glucose spikes decreases inflammation and along with it your risk of contracting any of these inflammation-based diseases.

Small numbers of senescent cells can cause widespread havoc. Even though they stop dividing, they continue to release tiny proteins called cytokines that cause inflammation and attract immune cells called macrophages that then attack the tissue. Being chronically inflamed is unhealthy: just ask someone with multiple sclerosis, inflammatory bowel disease, or psoriasis. All these diseases are associated with excess cytokine proteins.

For example, the inflammation-based model assumes that a chronically sore knee is caused by inflammation (tendinitis), and that the subsequent tendon degeneration that occurs over time (tendinosis) results from that chronic inflammation. Based on this model, most general practitioners believe that patients who present with overuse injuries require rest and anti-inflammatory medication to promote healing. But more recent studies cast doubt on this philosophy, and experts in the field of tendon health have created a new paradigm

This means that tendon degeneration is not simply the result of unchecked chronic inflammation. The degeneration and weakening of connective tissue in overuse injuries has a different cause. This is a key reason why tendinopathy has replaced tendinitis and tendinosis when referring to tendon pathology.

Symptoms of Systemic Inflammation Symptoms are far ranging, including everything from general fatigue to weight gain.44 Even if you are less concerned about overall health and more worried about your banged-up knees and elbows, pay close attention to this. Studies show low-grade systemic inflammation makes you more susceptible to tendinopathy and joint pain.45 While most people have one or two of these symptoms, you should seek medical guidance if several of these describe you: Weight gain (especially around the midsection) Fatigue, brain fog, general lethargy, insomnia Joint and muscle pain, spasms, muscle cramps Depressed mood and anxiety Digestive discomfort (gas, diarrhea, constipation, stomach cramps and pains) Skin disorders, including easily irritated skin, persistent redness or puffiness, eczema, and psoriasis Frequent infections, colds, and illnesses Frequent allergic reactions and allergy symptoms Symptoms of local chronic inflammation (in a specific region of the body) are more specific: Pain, swelling, irritation, or redness lasting longer than six weeks Progressive muscle weakness Progressive reductions in range of motion Causes and Risk Factors for Chronic Inflammation While some of these are out of your control—like genetics and age—you can influence most of these risk factors:

Take charge of hidden, sneaky sources of chronic inflammation that can trigger illness and disease by wearing comfortable shoes daily, getting an annual flu vaccine, and asking your doctor why you’re not on a statin and baby aspirin if you’re over the age of forty.

Calcification is the hardening of body tissues by calcium salts or deposits. Although calcification itself is not considered a disease, it has been shown to be a significant contributing factor in nearly every known illness and aging condition, including heart disease, kidney stones, gallstones, chronic inflammation, arthritis, cancers, cataracts, eczema, psoriasis, and even wrinkles.

Even if the body’s inflammatory response is a necessary part of its physiology to heal wounds, fight infection, and rebuild the muscles. However, too much inflammation leads to a number of conditions such as Alzheimer’s disease, atherosclerosis, arthritis, autonomous disorders, cancer, chronic pain, eczema, premature aging, and yeast infection. Sugar is an inflammatory food and having too much sugar in the body exposes it to a continuously inflamed state. Sugar detox helps prevent the foretasted conditions which put sugar addicts at a higher risk of contracting these conditions.

Numerous studies show that chronic stress lowers metabolic rate, decreases immunity, and increases inflammation. Shedding chronic stress has the opposite effect, improving health in every way.

The term “myalgic encephalomyelitis” (muscle pain, “myalgic”, with “encephalomyelitis” inflammation of the brain and spinal cord) was first included by the World Health Organization (WHO) in their International Classification of Diseases in 1969. It is ironic that Donald Acheson, who subsequently became the Chief Medical Officer first coined the name in 1956.8 In 1978 the Royal Society of Medicine accepted ME as a nosological organic entity.9 The current version of the International Classification of Diseases—ICD‐10, lists myalgic encephalomyelitis under G.93.3—neurological conditions. It cannot be emphasised too strongly that this recognition emerged from meticulous clinical observation and examination.

The label ‘Chronic Fatigue Syndrome’ was first proposed by Holmes et al. (1988) of the Centers for Disease Control (CDC). This name was recommended to replace that of a number of terms that implied a causal pathology (e.g. ‘Myalgic Encephalomyelitis’, ‘Post-Viral Fatigue Syndrome’ and ‘chronic Epstein-Barr virus syndrome’), as there was a lack of correlation between biological markers and symptomatology. Hence, this new label reflected the prime clinical characteristic of the condition without alluding to an underlying physical aetiology and, in turn, the definition was based upon signs and symptoms of the patient group. However, many individuals use the term Myalgic Encephalomyelitis (indicating muscle pain and inflammation of the brain), a fact that is reflected by the titles of the two largest charitable organisations in the UK, the ME Association and Action for ME.

Chronic     Your body’s initial, short-term response to damage. Think of acute inflammation as the cleanup before the rebuilding. It decreases quickly as your body begins the healing process. Acute inflammation is a good thing, and you wouldn’t want to lose that function.     Chronic

ME/CFS is a complex condition that affects every organ system in the body. There is evidence of inflammation at the cellular and biochemical levels: in the muscles, brain and spinal cord in patients with ME/CFS. The name for this illness has had a huge impact on the medical, scientific and patient communities – how it is viewed and how patients are treated by the medical community (160).

Chronic systemic inflammation plays a key role in more than just age-related diseases. Inflammation contributes to a long list of conditions that you may be dealing with right now. Like asthma, allergies, acne, eczema and other skin conditions, depression, ADHD, and mood swings. Do

Inflammation is the body’s natural response to invaders. I already discussed this problem and how “leaky gut” will lead to weight gain. It may be more important to note that “leaky gut” will lead to major health issues because it causes chronic inflammation. Cancer, asthma, headaches, allergies, arthritis, auto-immune disorders, heart disease, diabetes, depression, Alzheimer’s, and osteoporosis are all caused by chronic inflammation.

For example, researchers from Rice University learned that depression is connected to chronic inflammation.

Unhealthy diets don’t just affect the structure of your arteries; an unhealthy diet can also affect their functioning. Your arteries are not merely inert pipes through which blood flows. They are dynamic, living organs. We’ve known for nearly two decades that a single fast-food meal—Sausage and Egg McMuffins were used in the original study—can stiffen your arteries within hours, cutting in half their ability to relax normally.43 And just as this inflammatory state starts to calm down five or six hours later—lunchtime! You may once again whack your arteries with another load of harmful food, leaving many Americans stuck in a danger zone of chronic, low-grade inflammation. Unhealthy meals don’t just cause internal damage decades down the road but right here and now, within hours of going into your mouth.

Neutrophils Neutrophilia • Infection: bacterial, fungal • Trauma: surgery, burns • Infarction: myocardial infarct, pulmonary embolus, sickle-cell crisis • Inflammation: gout, rheumatoid arthritis, ulcerative colitis, Crohn’s disease • Malignancy: solid tumours, Hodgkin lymphoma • Myeloproliferative disease: polycythaemia, chronic myeloid leukaemia • Physiological: exercise, pregnancy Neutropenia • Infection: viral, bacterial (e.g. Salmonella), protozoal (e.g. malaria) • Drugs: see Box 24.11 • Autoimmune: connective tissue disease • Alcohol • Bone marrow infiltration: leukaemia, myelodysplasia • Congenital: Kostmann’s syndrome Eosinophils Eosinophilia • Allergy: hay fever, asthma, eczema • Infection: parasitic • Drug hypersensitivity: e.g. gold, sulphonamides • Skin disease • Connective tissue disease: polyarteritis nodosa • Malignancy: solid tumours, lymphomas • Primary bone marrow disorders: myeloproliferative disorders, hypereosinophilia syndrome (HES), acute myeloid leukaemia Basophils Basophilia • Myeloproliferative disease: polycythaemia, chronic myeloid leukaemia • Inflammation: acute hypersensitivity, ulcerative colitis, Crohn’s disease • Iron deficiency Monocytes Monocytosis • Infection: bacterial (e.g. tuberculosis) • Inflammation: connective tissue disease, ulcerative colitis, Crohn’s disease • Malignancy: solid tumours Lymphocytes Lymphocytosis • Infection: viral, bacterial (e.g. Bordetella pertussis) • Lymphoproliferative disease: chronic lymphocytic leukaemia, lymphoma • Post-splenectomy Lymphopenia • Inflammation: connective tissue disease • Lymphoma • Renal failure • Sarcoidosis • Drugs: corticosteroids, cytotoxics • Congenital: severe combined

one of the most important questions that you and your progressive Lyme-aware practitioner must determine is how much of your problem is due to chronic persistent Lyme infection (or co-infections) versus chronic inflammation/damage caused by the Lyme.

Protein and the Story of the AGEs Advanced glycation end-products (AGEs) can do some serious damage, especially over time. An article in The Clinical Journal of the American Society of Nephrology makes several important points about protein and its relationship to many of the diseases of aging: • Human studies indicate that excess dietary protein promotes progressive kidney damage by increasing the AGE burden. • A prudent approach is to recommend that people with chronic kidney disease achieve the recommended dietary allowance of protein—0.8 g/kg per day, or about 10 percent of total caloric intake— with an emphasis on high-quality protein, low in AGEs. • Conversely, very low dietary protein intake may lead to malnutrition, especially in those with advanced chronic kidney disease. • The dietary AGE load can be minimized by consuming nonmeat proteins. • There are several culinary methods that reduce AGE formation during cooking—steaming, poaching, boiling, and stewing. Frying, broiling, or grilling should be avoided, as they promote AGE formation. • Limitation of dietary AGEs seems prudent in those with obesity, diabetes, and other risk factors for chronic kidney disease.i With the gradual onset of kidney failure, acidosis again ensues and will lead to all types of inflammation and metabolic abnormalities. The preceding recommendations for how to avoid turning a meal into AGEs should become a major agingmanagement technology for Baby Boomers everywhere. — Leonard Smith, M.D.

Prednisone is the pharmaceutical equivalent of cortisol and works using the same mechanisms in the body. Prednisone is used in modern medicine to control inflammation in many different diseases such as severe asthma and autoimmune diseases. Well-known side effects of chronic prednisone (and other similar medications) use is fat gain, muscle wasting, bone weakening, and psychological side effects such as agitation. High levels of cortisol from chronic stress/threat activation can result in the same side effects as daily prednisone use.

Harm reduction is often perceived as being inimical to the ultimate purpose of “curing” addiction—that is, of helping addicts transcend their habits and heal. People regard it as coddling addicts, as enabling them to continue their destructive ways. It’s also considered to be the opposite of abstinence, which many regard as the only legitimate goal of addiction treatment. Such a distinction is artificial. The issue in medical practice is always how best to help a patient. If a cure is possible and probable without doing greater harm, then cure is the objective. When it isn’t—and in most chronic medical conditions cure is not the expected outcome—the physician’s role is to help the patient with the symptoms and to reduce the harm done by the disease process. In rheumatoid arthritis, for example, one aims to prevent joint inflammation and bone destruction and, in all events, to reduce pain. In incurable cancers we aim to prolong life, if that can be achieved without a loss of life quality, and also to control symptoms. In other words, harm reduction means making the lives of afflicted human beings more bearable, more worth living. That is also the goal of harm reduction in the context of addiction.

When we react to problems, as opposed to create with them, we get hooked into stress. When we are under constant low-grade stress—and it’s estimated that over 80 percent of us are all the time—this begins to hurt us.1 When we are stressed, our nervous system tightens up and we lose our creativity. Stress stops us learning, and if we aren’t learning, we aren’t growing.2 Stress, AKA fear, corrodes the curiosity and courage we need to experiment with the new. It is almost impossible to play big in life, if we are scared of looking like idiots, going bankrupt, or being rejected. Stress kills creativity and kills us too. Whereas small amounts of stress help us focus, engage, and learn, chronic or elevated stress burns us out, literally as well as metaphorically. People who live near airports and deal with the stress of giant airplanes roaring above them have higher rates of cardiac arrest than those who don’t.3 People who deal with a controlling or uncommunicative boss have a 60 percent higher chance of developing coronary heart disease than those who don’t.4 Stress leads to tangible changes inside all the cells of the body. Specific genes start to express proteins, which leads to inflammation; and chronic inflammation is associated with killers such as heart disease and cancer. Over time, stress reduces our ability to prevent aging, heal wounds, fight infections, and even be successfully immunized.5 Unmanaged stress, simply from having a sense of disempowerment at work, can be more dangerous than smoking or high cholesterol.

Ayurveda is useful in any chronic illness. Coronary artery disease, rheumatoid arthritis or other inflammations. Bronchial asthma, obesity, type 2 diabetes. Because these are all linked to lifestyle”. 

In addition to making us sick, chronic inflammation can make permanent weight loss fiendishly difficult. The fat cells keep churning out inflammatory proteins called cytokines, promoting even more inflammation. That inflammation in turn prevents the energy-making structures in the cells, called mitochondria, from doing their jobs efficiently, much like a heat wave would affect the output of a factory that lacks air-conditioning—productivity declines under extreme conditions. One of the duties of the mitochondria is burning fat; inflammation interferes with the job of the mitochondria, making fat burning more difficult and fat loss nearly impossible. While someone trying to lose weight

Like high blood pressure and diabetes, chronic inflammation has no visible symptoms (though it can be measured by a lab test known as high-sensitivity C-reactive protein [hs CRP]). But it damages the vascular system, the organs, the brain, and body tissues. It slowly erodes your health, gradually overwhelming the body’s anti-inflammatory defenses. It causes heart disease. It causes cognitive decline and memory loss. Even obesity and diabetes are linked to inflammation because fat cells are veritable factories for inflammatory chemicals. In fact, it’s likely that inflammation is the key link between obesity and all the diseases obesity puts you at risk for developing. When your joints are chronically inflamed, degenerative diseases like arthritis are right around the corner. Inflamed lungs cause asthma and other respiratory illnesses. Inflammation in the brain is linked to Alzheimer’s disease and other neurological conditions, including brain fog and everyday memory lapses that we write off as normal aging—except those memory lapses are not an inevitable consequence of aging at all. They are, however, an inevitable consequence of inflammation, because inflammation sets your brain on fire. Those “I forgot where I parked the car” moments start happening more frequently, and occurring prematurely. Inflamed arteries can signal the onset of heart disease. Chronic inflammation has also been linked to various forms of cancer; it triggers harmful changes on a molecular level that result in the growth of cancer cells. Inflammation is so central to the process of aging and breakdown at the cellular level that some health pundits have begun referring to the phenomena as “inflam-aging.” That’s because inflammation accelerates aging, including the visible signs of aging we all see in the skin. In addition to making us sick, chronic inflammation can make permanent weight loss fiendishly difficult. The fat cells keep churning out inflammatory proteins called cytokines, promoting even more inflammation. That inflammation in turn prevents the energy-making structures in the cells, called mitochondria, from doing their jobs efficiently, much like a heat wave would affect the output of a factory that lacks air-conditioning—productivity declines under extreme conditions. One of the duties of the mitochondria is burning fat; inflammation interferes with the job of the mitochondria, making fat burning more difficult and fat loss nearly impossible. While someone trying to lose weight may initially be successful, after a while, the number on the scale gets stuck. The much-discussed weight-loss “plateau” is often a result of this cycle of inflammation and fat storage. And here’s even more bad news: Adding more exercise or eating fewer calories in an attempt to break through the plateau will have some effect on weight loss, but not much. And continuing to lose weight becomes much harder to accomplish. Why? Because inflammation decreases our normal ability to burn calories. (We’ll tell you more about other factors that contribute to the plateau—and how the Smart Fat Solution can help you to move beyond them—in Part 2 of this book.)

This variant is causing your body’s immune system to attack itself. The body is designed to send white blood cells to attack anything it sees as a threat. That could be bacteria, a virus, or any number of toxins. For example, if you get a cut on your finger, the injury site might be red, sore, swollen—that’s a healthy form of inflammation. We call that acute inflammation. “But sometimes, the immune response causes problems. Examples of that are people with peanut or shellfish allergies. Their bodies perceive those foods to be dangerous when they actually aren’t. Arthritis is another example of inflammation causing harm. In this instance, inflammatory cells attack joint tissue. We call this chronic inflammation.

Other conditions that are associated with chronic inflammation are heart disease, Alzheimer’s, asthma, cancer, and diabetes. It’s not healthy. This variant is causing our cells to secrete a disproportionate number of cytokines, which are proteins that signal our bodies to produce more inflammatory cells.

conditions that can set the stage for Hashimoto’s. These include gluten intolerance, estrogen surges, insulin resistance, polycystic ovary syndrome (PCOS), vitamin D deficiency, environmental toxicity, chronic infections and inflammation, and genetic susceptibility to the condition.

In patients with chronic fatigue, inflammation often builds up in the limbic system, the part of the brain that stores survival instincts, emotions, and memories. Inflammation in the limbic system can result in heightened anxiety and PTSD-type responses. And heightened anxiety can generate more inflammation in the brain.

Early stresses could create abnormal stress responses, favoring fight-or-flight, which generated chronic inflammation.

If we can get the mitochondria working at its proper level with deuterium-depleted water, tamp down inflammation with cannabis, and then send the all-clear signal with a compound like suramin, we might be setting the stage to heal even our most challenging chronic diseases.

I monitor several biomarkers related to metabolism, keeping a watchful eye for things like elevated uric acid, elevated homocysteine, chronic inflammation, and even mildly elevated ALT liver enzymes. Lipoproteins, which we will discuss in detail in the next chapter, are also important, especially triglycerides; I watch the ratio of triglycerides to HDL cholesterol (it should be less than 2:1 or better yet, less than 1:1), as well as levels of VLDL, a lipoprotein that carries triglycerides—all of which may show up many years before a patient would meet the textbook definition of metabolic syndrome. These biomarkers help give us a clearer picture of a patient’s overall metabolic health than HbA1c, which is not very specific by itself.

There is no more underrated and research-backed therapeutic tool than walking. It reduces back pain, and body pain in general, through dozens of mechanisms. Studies show that walking does the following: Increases circulation of natural opioids in the body175 Reduces pain sensitivity176 Stimulates production and circulation of synovial fluid within joints177 Improves lumbar (low back) function178 Strengthens foot muscles, creating a more stable and pliable base for the hips, back, and neck (especially in minimalist shoes)179 Reduces perceived pain levels, improves blood pressure, and strengthens feelings of personal power180 (if you walk with upright posture instead of slumped) Reduces bone density loss with age, helping to prevent osteoporosis and reduce osteoarthritis pain181 Is a surprisingly effective weight loss and weight management technique, which in turn keeps overall compression forces on joints down182 Increases blood flow to spinal muscles, improving oxygen and nutrient delivery required for cellular healing183 Speeds up elimination of cellular waste products through the repeated contractions of various muscle groups throughout the body183 Reduces the levels of the stress hormone, cortisol, which has a correlative relationship with subjective pain levels184 (Barefoot walking) Improves body awareness and wound healing, reduces inflammation, and helps prevent chronic inflammatory diseases185 Walking doesn’t just help relieve back pain—it targets the central causes of pain. And as you can see from the many studies on walking and pain relief, the benefits are not limited to the locomotion of walking. It’s movement in general that increases circulation of natural opioids, reduces pain sensitivity, stimulates synovial fluid production, and supports cellular health.

Coffee is among the most studied food in science. One of its well-known abilities is to promote fat-burning. As the beverage highest in caffeine, it has been shown to reduce stored body fat, especially belly fat, and lower the risk of diabetes, liver and colon cancer, cardiovascular disease, and chronic inflammation.

A key to avoiding chronic inflammation is in balancing one’s dietary fat intake by eating only natural fats, avoiding junk food, and consuming healthy foods. In doing so, many problems like muscle imbalance, weak bones, injuries, chronic diseases, even mental-emotional illness can be prevented.

Instead of blazing acutely in one spot for a few days or weeks, as when we fight a cold, inflammation can smolder imperceptibly in many parts of the body for months or years. In a way, chronic, low-grade inflammation is like having a never-ending cold so mild you never notice its existence. But the inflammation is nonetheless there, and mounting evidence indicates that this slow burn steadily and surreptitiously damages tissues in our arteries, muscles, liver, brain, and other organs.

Last, and perhaps most important, prolonged sitting can kindle chronic inflammation by allowing muscles to remain persistently inactive. In addition to moving our bodies, muscles function as glands, synthesizing and releasing dozens of messenger proteins (termed myokines) with important roles. Among other jobs, myokines influence metabolism, circulation, and bones, and—you guessed it—they also help control inflammation. In fact, when researchers first started to study myokines, they were astonished to discover that muscles regulate inflammation during bouts of moderate to intense physical activity similarly to the way the immune system mounts an inflammatory response to an infection or a wound.40 Without going into too many details, we have learned that the body first initiates a proactive inflammatory response to moderate- or high-intensity physical activity to prevent or repair damage caused by the physiological stress of exercise and subsequently activates a second, larger anti-inflammatory response to return us to a non-inflamed state.41 Because the anti-inflammatory effects of physical activity are almost always larger and longer than the pro-inflammatory effects, and muscles make up about a third of the body, active muscles have potent anti-inflammatory effects. Even modest levels of physical activity dampen levels of chronic inflammation, including in obese people.42

Long hours of commuting, a demanding desk job, being sick or disabled, or otherwise being confined to a chair can be stressful situations that elevate the hormone cortisol. This much-misunderstood hormone doesn’t cause stress but instead is produced when we are stressed, and it evolved to help us cope with threatening situations by making energy available. Cortisol shunts sugar and fats into the bloodstream, it makes us crave sugar-rich and fat-rich foods, and it directs us to store organ fat rather than subcutaneous fat. Short bursts of cortisol are natural and normal, but chronic low levels of cortisol are damaging because they promote obesity and chronic inflammation. Consequently, long hours of stressful sitting while commuting or a high-pressure office job can be a double whammy.

Not only does our individual and societal sanity depend on connection; so does our physical health. Because we are biopsychosocial creatures, the rising loneliness epidemic in Western culture is much more than just a psychological phenomenon: it is a public health crisis. A preeminent scholar of loneliness, the late neuroscientist John Cacioppo and his colleague and spouse, Stephania Cacioppo, published a letter in the Lancet only a month before his death in 2018. "Imagine," they wrote, "a condition that makes a person irritable, depressed, and self-centered, and is associated with a 26% increase in the risk of premature mortality. Imagine too that in industrialized countries around a third of people are affected by this condition, with one person in 12 affected severely, and that these proportions are increasing. Income, education, sex, and ethnicity are not protective, and the condition is contagious. The effects of the condition are not attributable to some peculiarity of the character of a subset of individuals, they are a result of the condition affecting ordinary people. Such a condition exists — loneliness." We now know without doubt that chronic loneliness is associated with an elevated risk of illness and early death. It has been shown to increase mortality from cancer and other diseases and has been compared to the harm of smoking fifteen cigarettes a day. According to research presented at the American Psychological Association's annual convention in 2015, the loneliness epidemic is a public health risk at least as great as the burgeoning rates of obesity. Loneliness, the researcher Steven Cole told me, can impair genetic functioning. And no wonder: even in parrots isolation impairs DNA repair by shortening chromosome-protecting telomeres. Social isolation inhibits the immune system, promotes inflammation, agitates the stress apparatus, and increases the risk of death from heart disease and strokes. Here I am referring to social isolation in the pre COVID-19 sense, though the pandemic has grievously exacerbated the problem, at great cost to the well-being of many.