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A transient hemodynamic improvement is often seen when a bolus of sodium bicarbonate (e.g., an "amp") is given, but this is more likely due to the loading of sodium than the change in pH—similar effects are seen with bolus dosing of hypertonic saline. Keep in mind that the NaHCO3 given in a 50 mL ampule is 8.4%, which is a very hypertonic sodium solution.
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